CN115590802A

CN115590802A - Toothpaste with anti-allergy and breath freshening effects and preparation process thereof

Info

Publication number: CN115590802A
Application number: CN202211110772.1A
Authority: CN
Inventors: 魏鉴宜; 梁焕玲
Original assignee: Guangdong South Jele Technology Industrial Co ltd
Current assignee: Guangdong South Jele Technology Industrial Co ltd
Priority date: 2022-09-13
Filing date: 2022-09-13
Publication date: 2023-01-13

Abstract

The invention belongs to the field of daily chemicals, and particularly relates to toothpaste with anti-allergy and breath freshening effects, which comprises the following components in percentage by weight: 0.01 to 1 percent of turmeric extract, 0.1 to 0.5 percent of strontium chloride, 0.02 to 1 percent of zinc citrate, 0.01 to 6 percent of glycolipid, 5 to 10 percent of calcium hydrophosphate, 0.5 to 2 percent of hydroxyethyl cellulose, 1 to 2 percent of xanthan gum, 1 to 3 percent of glycerol laurate, 8 to 12 percent of cyclodextrin, 1 to 2 percent of betaine, 1 to 3 percent of vitamin C, 1 to 5 percent of xylitol, 20 to 25 percent of polyethylene glycol, 15 to 20 percent of glycerol, 1 to 3 percent of lemon oil, 0.5 to 1.5 percent of sodium chloride and the balance of water. Also provides a preparation process of the toothpaste with anti-allergy and breath freshening effects. The toothpaste has good antiallergic effect, and can refresh breath for a long time.

Description

Toothpaste with anti-allergy and breath freshening effects and preparation process thereof

Technical Field

The invention relates to the field of daily chemicals, in particular to toothpaste with anti-allergy and breath freshening effects and a preparation process thereof.

Background

Along with the improvement of living standard of people, everyone pays special attention to oral hygiene, and also especially hopes to select satisfactory toothpaste, so that the toothpaste is suitable for the people to be clean and sanitary in the oral cavity.

When the teeth are stimulated by cold, heat, acid, sweet and mechanical action (rubbing, biting), a sensation of soreness is suddenly produced, or it is flashed off, or it is briefly sustained, which sensation of soreness disappears when the stimulus is removed. When the doctor examines the tooth, the probe can also be used to detect sensitive points on the tooth.

The cause of tooth sensitivity is also described in terms of tooth structure. The sensation of soreness during tooth sensitivity is fundamentally derived from the dental nerves in the pulp. Normally, the pulp is within the envelope of dentin, which in turn is within the envelope of enamel. Enamel is a smooth, hard, dense substance that is the most primitive and effective line of defense of teeth. The dentin itself has many fine pores. Therefore, if the enamel is partially damaged for some reason, external stimuli such as hot, cold, sour and sweet sensations are transmitted to the tooth pulp through the holes, causing a feeling of soreness.

The wear on teeth in daily life is caused by various problems, such as chewing food, using too coarse toothpaste particles, and the like. The long-term abrasion of teeth can damage the enamel on the outer layer to expose the dentin inside, and if external stimuli such as cold, heat, acid, sweet and the like are met, the stimuli can be quickly transmitted to dental pulp through dentinal tubules to cause pain.

In the oral cavity of human beings, a plurality of bacteria capable of decomposing protein putrefaction are parasitized, the bacteria are mainly anaerobic bacteria, and can decompose protein substances, generate volatile sulfide and other peculiar smell substances, so that the oral cavity generates foul smell, and other people can be impressed with bad impression to influence the interaction.

A lot of consumers form tooth stains due to the fact that a large amount of pigment is deposited on teeth when smoking, eating colored foods and the like, meanwhile, the deposited tooth stains are easy to breed bacteria to generate unpleasant smell, and much trouble is brought to daily life of the consumers, so that an oral cleaning and nursing product with good stain removing and breath freshening effects is developed, the consumers are helped to solve the problems, and great social benefits and economic benefits are achieved.

Antibacterial and anti-inflammatory toothpaste also appears in the market, the variety of the toothpaste is full of Lin and the method for solving the problems of tooth allergy and breath freshening by adding various medicinal active ingredients is diversified; however, these existing antibacterial and anti-inflammatory toothpastes cannot provide good care for periodontal disease as long as they are used for sterilization and have short effective sterilization time, and the toothpaste has short retention time of aroma and cannot provide breath freshening function for a long time.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide the toothpaste with the functions of resisting allergy and refreshing breath, the toothpaste not only has the function of cleaning teeth and oral cavity, but also has good relieving effect on tooth ache caused by tooth allergy such as tooth abrasion, gingival atrophy, tooth root exposure, cold, hot, sour and sweet and the like; and because the toothpaste contains components with the effects of inhibiting inflammation, resisting oxidation and the like, the toothpaste can keep fresh breath for a long time after tooth brushing through the treatment of a special method.

The second purpose of the invention is to provide a preparation process of toothpaste with anti-allergy and breath freshening effects, and the toothpaste prepared by the process can better exert the effects of the active ingredients in the toothpaste.

In order to achieve one of the above purposes, the invention provides the following technical scheme:

provides toothpaste with anti-allergy and breath freshening effects, which comprises the following components in percentage by weight: 0.01 to 1 percent of turmeric extract, 0.1 to 0.5 percent of strontium chloride, 0.02 to 1 percent of zinc citrate, 0.01 to 6 percent of glycolipid, 5 to 10 percent of calcium hydrophosphate, 0.5 to 2 percent of hydroxyethyl cellulose, 1 to 2 percent of xanthan gum, 1 to 3 percent of glycerol laurate, 8 to 12 percent of cyclodextrin, 1 to 2 percent of betaine, 1 to 3 percent of vitamin C, 1 to 5 percent of xylitol, 20 to 25 percent of polyethylene glycol, 15 to 20 percent of glycerol, 1 to 3 percent of lemon oil, 0.5 to 1.5 percent of sodium chloride and the balance of water.

The components of the toothpaste are food-grade or medicinal-grade raw materials, and the water is deionized water or purified water.

The Curcuma rhizome extract is derived from dried rhizome of Curcuma rhizome of Zingiberaceae, and contains main ingredients of turmerone, arylturmerone, zingiberene, curcumin, etc.; it has antioxidant, antiinflammatory, anticoagulant, and blood lipid reducing effects.

The strontium chloride is a toothpaste desensitizer.

The zinc citrate is used as a zinc supplement and has effects in inhibiting oral bacteria, controlling dental plaque, relieving bad breath, resisting dental calculus, relieving gum problem, and preventing dental caries.

The glycolipid is a rhamnolipid, is an anionic biosurfactant produced by a microorganism, and has good chemical and biological properties. Has both oleophylic and hydrophilic amphipathy, can reduce the surface tension of water, and is used as a wetting agent, an emulsifying agent and a foaming agent.

The dibasic calcium phosphate is used as an abrasive.

The hydroxyethyl cellulose is an adhesive.

The xanthan gum is good in acid-base and thermal temperature properties. Xanthan gum is added as a stabilizer, emulsifier, suspending agent, thickener and processing aid for use in spray drying granulation.

The lauric acid glyceride, namely the lauric acid monoglyceride, is a lipophilic nonionic surfactant, can also be used as a gelling agent, and has the effects of clearing lung-heat, eliminating phlegm, clearing heat, eliminating dampness, nourishing yin, reducing pathogenic fire, cooling blood and stopping bleeding.

The cyclodextrin is one or a composition of more than two of alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin.

The betaine is one or more of dodecyl dimethyl betaine, tetradecyl dimethyl betaine, octadecyl dimethyl betaine, dodecyl dihydroxyethyl betaine, and octadecyl dihydroxyethyl betaine. Used as a foaming agent in toothpaste.

The vitamin C, used as a nutritional supplement to prevent or treat scurvy; can also be used as acidity regulator for antioxidant and antiseptic.

The xylitol is a sweetener.

The polyethylene glycol is polyethylene glycol 400.

The glycerin serves as both a solvent and a humectant along with the polyethylene glycol.

The lemon oil is a spice. In particular, different essence and spice components can be added according to the preference of the public, so that the requirements of various crowds are met.

The sodium chloride is edible salt and has the function of supplementing electrolyte.

In order to achieve the second purpose, the invention provides the following technical scheme:

the preparation process of the toothpaste with the functions of anti-allergy and breath freshening is provided, and comprises the following steps:

s1, adding turmeric extract, xanthan gum, glyceryl laurate and cyclodextrin into a solvent according to the formula amount, heating, mixing, dissolving, drying and granulating to obtain a first component;

s2, grinding and uniformly mixing calcium hydrophosphate, glycolipid, hydroxyethyl cellulose, betaine, polyethylene glycol, glycerol and lemon oil according to the formula amount under a vacuum condition to obtain a second component;

s3, mixing and dissolving strontium chloride, zinc citrate, vitamin C, xylitol, sodium chloride and water according to the formula amount to obtain a third component;

and S4, uniformly mixing the second component and the third component under a vacuum condition, adding the first component, dispersing and uniformly mixing to obtain a paste body, and thus obtaining the toothpaste with the anti-allergy and breath freshening effects.

In the above technical scheme, the solvent in the step S1 is ethanol; the temperature for heating, mixing and dissolving is 30-70 ℃; the temperature for drying and granulating is 45-100 ℃.

In the above technical solution, in the step S1, the drying and granulating method is spray drying and granulating.

In the above technical solution, in the step S1, the particle size of the particles obtained by drying and granulating is 5 to 20 micrometers.

In the above technical scheme, the vacuum condition of the step S2 and the step S4 is that the vacuum degree is-0.09 to-0.1 MPa.

The beneficial effects of the toothpaste

(1) The toothpaste with the functions of anti-allergy and breath freshening not only has the function of cleaning teeth and oral cavity; after the strontium chloride is added, the solubility of the strontium chloride is reduced through the salting-out effect of greening sodium, so that the strontium chloride can smoothly enter a large number of tiny cavities in dentin, and the ache effect caused by external stimulators transmitted to dental pulp through the cavities is prevented, thereby achieving the anti-allergy effect of increasing the strontium chloride as a toothpaste desensitizer, and having good relieving effects on dental ache caused by tooth abrasion, gingival atrophy, tooth root exposure, tooth allergy such as cold, hot, sour and sweet and the like.

The toothpaste also contains Curcuma rhizome extract with effects of inhibiting inflammation and resisting oxidation, and can keep fresh breath for a long time after brushing teeth by special treatment method.

(2) The preparation process of the toothpaste with the functions of anti-allergy and breath freshening comprises the steps of mixing turmeric extract, xanthan gum, glyceryl laurate and cyclodextrin in advance, granulating and dispersing in the toothpaste; during the tooth brushing process, the turmeric extract is dispersed into the oral cavity under the action of the surface tension of the foaming agent, is well adhered to the oral mucosa due to the lipophilic action of the lauric glyceride and the cyclodextrin, and cannot be washed out under the action of the mouthwash due to good hydrophobicity, so that the turmeric extract contained in the turmeric extract has a lasting action on the oral mucosa due to the effects of inflammation inhibition and oxidation resistance.

The rhamnolipid in the toothpaste has the amphiphilic effect of oleophylicity and hydrophily, and a protective film can be added when the particles are attached to the oral mucosa. It also has anti-inflammatory effect for inhibiting growth of bacteria and fungi, and can be used as oral cavity deodorant for refreshing breath. Meanwhile, the lipophilic nature of the toothpaste enables the toothpaste to be attached to oral mucosa, so that other water-soluble ingredients in the toothpaste are kept in the oral cavity and cannot be easily washed out by water.

Detailed Description

In the illustrated embodiment of the invention, according to the components and corresponding percentage contents of the toothpaste, several groups of data are selected to prepare the paste according to the preparation method of the toothpaste, and the specific data are shown in table 1:

the toothpaste comprises 0.01-1% of turmeric extract, 0.1-0.5% of strontium chloride, 0.02-1% of zinc citrate, 0.01-6% of glycolipid, 5-10% of calcium hydrophosphate, 0.5-2% of hydroxyethyl cellulose, 1-2% of xanthan gum, 1-3% of glycerol laurate, 8-12% of cyclodextrin, 1-2% of betaine, 1-3% of vitamin C, 1-5% of xylitol, 20-25% of polyethylene glycol, 15-20% of glycerol, 1-3% of lemon oil, 0.5-1.5% of sodium chloride and the balance of water.

According to the formula content of the toothpaste components, the preparation method comprises the following steps:

and S4, uniformly mixing the second component and the third component under a vacuum condition, then adding the first component, and uniformly dispersing and mixing to obtain an ointment, namely the toothpaste with the anti-allergy and breath freshening effects.

The preparation process of the toothpaste disclosed by the invention is adopted in the examples 1, 2, 3 and 4 and the comparative examples 1, 2 and 3.

In the process for preparing the toothpaste of comparative example 4, in step S1, a solid powder of the first component mixture was obtained by a conventional drying method, and the processes in the other steps were the same.

TABLE 1 selection of toothpaste ingredients specific examples and comparative examples

In order to verify the toothpaste with the anti-allergy and breath freshening effects, the applicant marks several toothpastes in the embodiments and packages the toothpastes in groups, each group randomly selects experiencers or hypersensitive teeth for trial use, and each experiencer performs tracking test on each experiencer strictly according to the dosage and time frequency every day.

As a result, the four toothpastes of examples 1, 2, 3 and 4 had good anti-sensitivity effect and fresh breath effect for at least 3 hours or more; the toothpaste of comparative example 1 had good and lasting breath freshening effect although it did not have anti-dental sensitivity effect due to the absence of strontium chloride; the toothpaste of comparative example 2 had anti-allergy effect but the breath freshening time was only about 1h because no turmeric extract was added; the toothpaste of comparative example 3 has good anti-allergy effect due to lack of glycolipid, and breath freshening time is about 1.5h; the toothpaste of comparative example 4 had an anti-sensitivity effect, and was effective in keeping fresh breath for only half an hour.

The product is tried out by all experiencers for at least three months, no people can reflect uncomfortable feeling to the body, and the toothpaste disclosed by the invention has the safety and no toxic or harmful effect on the human health.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Toothpaste performance test experiment

After the toothpaste prepared in the four groups of examples 1, 2, 3 and 4 is prepared in a toothpaste making machine, the prepared toothpaste is put into toothpaste bottles made of conventional materials, and the stability experiment is carried out by sampling according to the following conditions respectively, wherein each group is subjected to sampling detection analysis according to requirements and strictly according to a specified time period. The stability test conditions comprise a room temperature frame test, a cold resistance test, a heat resistance test and an accelerated aging test, and the conditions are as follows:

and sampling and detecting the test sample according to the detection items and methods in national standards such as national standard GB/T8372-2017 toothpaste and the like.

Detection indicators include, but are not limited to, the following:

sensory indexes are as follows: paste and fragrance.

Physical and chemical indexes: paste extrusion pressure, consistency, amount of foam, stability, overly hard particles, PH, diethylene glycol, total fluorine, soluble fluorine, heavy metals, arsenic.

The sanitation index is as follows: total bacteria, staphylococcus aureus, pseudomonas aeruginosa, faecal coliform, pseudomonas aeruginosa, staphylococcus aureus, shigella, salmonella and the like.

The turmeric extract in the toothpaste is detected by adopting an HPLC method, each group of samples are detected in a stability experiment sample, and no obvious degradation byproduct is found by contrasting the turmeric extract, so that the turmeric extract in the toothpaste has better stability and safety.

As a result, the toothpaste of the present invention has good stability, and is safe to human health, except that the viscosity of the toothpaste is lowered at 60 ℃ (due to the increased solubility of the ingredients in the composition at high temperature).

Claims

1. The toothpaste with the functions of anti-allergy and breath freshening is characterized by comprising the following components in percentage by weight: 0.01 to 1 percent of turmeric extract, 0.1 to 0.5 percent of strontium chloride, 0.02 to 1 percent of zinc citrate, 0.01 to 6 percent of glycolipid, 5 to 10 percent of calcium hydrophosphate, 0.5 to 2 percent of hydroxyethyl cellulose, 1 to 2 percent of xanthan gum, 1 to 3 percent of glycerol laurate, 8 to 12 percent of cyclodextrin, 1 to 2 percent of betaine, 1 to 3 percent of vitamin C, 1 to 5 percent of xylitol, 20 to 25 percent of polyethylene glycol, 15 to 20 percent of glycerol, 1 to 3 percent of lemon oil, 0.5 to 1.5 percent of sodium chloride and the balance of water.

2. The toothpaste having anti-allergy and breath-freshening effects as claimed in claim 1, wherein said glycolipid is a rhamnolipid.

3. The toothpaste with anti-allergy and breath freshening effects as claimed in claim 1, wherein the cyclodextrin is one or a combination of more than two of α -cyclodextrin, β -cyclodextrin and γ -cyclodextrin.

4. The toothpaste with anti-allergy and breath freshening effects as claimed in claim 1, wherein the betaine is one or a combination of two or more of dodecyl dimethyl betaine, tetradecyl dimethyl betaine, octadecyl dimethyl betaine, dodecyl dihydroxyethyl betaine, and octadecyl dihydroxyethyl betaine.

5. The toothpaste with anti-allergy and breath freshening effects as claimed in claim 1, wherein the polyethylene glycol is polyethylene glycol 400.

6. A method for preparing toothpaste with anti-allergy and breath freshening effects as claimed in any one of claims 1 to 5, comprising the steps of:

7. The method for preparing toothpaste with anti-allergy and breath freshening effects as claimed in claim 6, wherein the solvent in step S1 is ethanol; the temperature for heating, mixing and dissolving is 30-70 ℃; the temperature for drying and granulating is 45-100 ℃.

8. The method for preparing toothpaste with anti-allergy and breath freshening effects according to claim 6, wherein in step S1, the drying granulation method is spray drying granulation.

9. The method for preparing toothpaste with anti-allergy and breath freshening effects as claimed in claim 6, wherein in step S1, the particle size of the particles obtained by drying and granulating is 5-20 μm.

10. The method for preparing toothpaste with anti-allergy and breath freshening effects according to claim 6, wherein the vacuum conditions in step S2 and step S4 are vacuum degree of-0.09 to-0.1 Mpa; in the step S2, the grinding time is 10 to 30 minutes.