CN115569098B - A Physalis alkekengi extract for caring skin - Google Patents

A Physalis alkekengi extract for caring skin Download PDF

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CN115569098B
CN115569098B CN202211246536.2A CN202211246536A CN115569098B CN 115569098 B CN115569098 B CN 115569098B CN 202211246536 A CN202211246536 A CN 202211246536A CN 115569098 B CN115569098 B CN 115569098B
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parts
calyx
extraction
skin care
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CN115569098A (en
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曹原
眭春
魏明明
周兰
孙玮哲
夏翡翡
曹珊
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Lanke Yimei Science And Technology Jilin Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/82—Preparation or application process involves sonication or ultrasonication
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Molecular Biology (AREA)
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  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a sour slurry extract for skin care, which comprises the following raw materials: berry extract, calyx extract, alcohol phosphate, soybean lecithin, cetyl palmitate, stearyl glycyrrhetinate, and flos Chrysanthemi extract. The extract of the physalis alkekengi berries has good inhibition effect on bacteria, and the extract of the calyx contains more ascorbic acid and flavonoid compounds, so that the extract of the calyx has good antioxidation effect and can reduce DNA damage caused by ultraviolet irradiation. Stearyl alcohol glycyrrhetinate has the effects of relieving and resisting allergic skin conditioning, soybean lecithin plays a key role in maintaining the physiological activity of a biological film and normal metabolism of an organism, plays a very important role in beautifying skin, and chrysanthemum extract can resist bacteria, resist inflammation, condition skin and prevent acne, and has quite good inhibition effect on skin inflammation.

Description

A Physalis alkekengi extract for caring skin
Technical Field
The invention relates to the technical field of acid pulp extracts, in particular to an acid pulp extract for skin care.
Background
The Physalis alkekengi (Physalis alkekengi) is dried fruit of Physalis alkekengi of Solanaceae or fruit-bearing fruit. The fruits are spherical berries, are orange-red in color when mature, and have enlarged calyx like a lantern which loosely surrounds the berries, so that the fruits are also called as calyx seu fructus physalis, golden hanging lamps and the like. The Chinese herbal medicines are recorded in Shen nong Ben Cao Jing (Shen nong's herbal medicine), are listed as middle-grade products, have the effects of relieving dysphoria and fever, stabilizing and invigorating qi, promoting urination and the like, and have records on the properties and the effects in a plurality of ancient materia medica logics such as "Zheng Ben Cao" (New modified materia Medica) and "Ben Cao gang mu Mi". The sour berry fruits have rich nutrition and good edible value, and in the late autumn or early winter, people in the north wear the sour berry fruits in strings under eave until frost, and eat the berries. In recent years, modern researches on the physalis alkekengi have been reported to a large extent, so far, a plurality of scholars at home and abroad commonly separate the whole grass, fruits, calyx and stems and leaves of the genus plants to obtain more than one hundred compounds, mainly comprising various types of compounds such as steroids (mainly physalis alkekengi bitter elements and withanolides), sterols, flavonoids, alkaloids, organic acids, carotenoids, pigments, amino acids, triterpenes, sesquiterpenes and polysaccharides. Among them, steroid (sour pulp bitter element) and flavonoid (luteolin) compounds are hot spots of research in recent years.
Whereas the berry and calyx of the physalis alkekengi contain more active properties, they can be used in skin care, the skin of people is exposed to environmental aggressions including Ultraviolet (UV) radiation for a long period of time. The result of this exposure can be the accumulation of senescent keratinocytes. These keratinocytes can negatively affect the structure and function of the skin. In particular, UV radiation applied to the skin can lead to the production of intracellular Reactive Oxygen Species (ROS), which can cause DNA damage. Such DNA damage can stimulate induction of cellular senescence. The visual result of this process is skin aging. The first line of defense against this reaction was to use antioxidants provided by healthy diets found in our body. Another opportunity to reduce the effects of such exposure is to use antioxidants applied to the skin surface via personal care products. Antioxidants have the ability to quench environmentally induced free radicals before they cause downstream effects.
There are relatively few reports of the application of the prior art extracts to skin care, so the present application provides an extract of physalis alkekengi for skin care.
Disclosure of Invention
The present invention is directed to a physalis alkekengi extract for skin care, which solves the above-mentioned problems of the prior art.
In order to solve the technical problems, the invention provides the following technical scheme: a physalis alkekengi extract for skin care comprises the following raw materials in parts by weight: 60-80 parts of berry extract, 30-40 parts of calyx extract, 3-6 parts of alcohol phosphate, 3-6 parts of soybean lecithin, 2-5 parts of cetyl palmitate, 2-5 parts of stearyl glycyrrhetinate and 1-5 parts of chrysanthemum extract.
In a preferred embodiment, the composition comprises the following raw materials in parts by weight: 65-75 parts of berry extract, 33-37 parts of calyx extract, 4-5 parts of alcohol phosphate, 4-5 parts of soybean lecithin, 3-4 parts of cetyl palmitate, 3-4 parts of stearyl glycyrrhetinate and 2-4 parts of chrysanthemum extract.
In a preferred embodiment, the composition comprises the following raw materials in parts by weight: 70 parts of berry extract, 35 parts of calyx extract, 4.5 parts of alcohol phosphate, 4.5 parts of soybean lecithin, 3.5 parts of cetyl palmitate, 3.5 parts of stearyl glycyrrhetinate and 3 parts of chrysanthemum extract.
In a preferred embodiment, the alcohol phosphate is a C12-13 alcohol phosphate.
In a preferred embodiment, the method for preparing the acid pulp extract for skin care comprises the following steps:
step one: preparing berry extract, cleaning and drying the sour slurry berries, crushing and screening the dried berries, placing the screened berries in an extraction kettle, performing supercritical extraction on the berries by using carbon dioxide fluid, and obtaining the berry extract for later use after extraction and separation;
step two: preparing a calyx extract, namely separating the calyx from the acid pulp, drying, crushing and screening the selected calyx, placing the screened calyx in an extraction kettle, performing supercritical extraction on the calyx by using carbon dioxide fluid, and extracting and separating to obtain the calyx extract for later use;
step three: preparing flos Chrysanthemi extract, weighing flos Chrysanthemi, pulverizing to obtain flos Chrysanthemi superfine powder, adding extractant into flos Chrysanthemi superfine powder, heating and reflux extracting for 3-4 times, filtering to collect filtrate, and concentrating the filtrate under reduced pressure to obtain flos Chrysanthemi extract;
step four: the preparation of the physalis alkekengi extract, namely uniformly mixing the berry extract obtained in the first step, the calyx extract obtained in the second step and the chrysanthemum extract obtained in the third step under the assistance of ultrasonic waves, then sequentially adding alcohol phosphate, soybean lecithin, cetyl palmitate and stearyl glycyrrhetinate, and uniformly stirring and mixing to obtain the physalis alkekengi extract for skin care.
In a preferred embodiment, the flow rate of carbon dioxide in the supercritical extraction in the first step is 17-23L/h, the extraction pressure in the extraction kettle is 28-32MPa, the extraction temperature is 40-45 ℃, and the extraction time is 2-3h.
In a preferred embodiment, the flow rate of carbon dioxide in the supercritical extraction in the second step is 20-24L/h, the extraction pressure in the extraction kettle is 30-35MPa, the extraction temperature is 40-45 ℃, and the extraction time is 2-4h.
In a preferred embodiment, the crushing and screening in the first step is carried out by using a No. 5-9 sieve, and the crushing and screening in the second step is carried out by using a No. 4-8 sieve.
In a preferred embodiment, the temperature of the heating reflux in the third step is 60-70 ℃, and the time of the heating reflux is 1-3h.
In a preferred embodiment, the ultrasonic frequency of the ultrasonic wave in the fourth step is 25-50KHz, and the ultrasonic auxiliary mixing time is 1-2h.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention adopts the berries and the calyx of the physalis as raw materials, extracts the berries and the calyx by utilizing a supercritical extraction technology, the extracts of the berries of the physalis have good inhibition effect on bacteria, the inhibition zones on staphylococcus aureus, escherichia coli and bacillus subtilis are respectively 16.63mm, 14.97mm and 12.47mm, the extracts of the calyx contain more ascorbic acid and flavonoid compounds, the clearance rate of the extracts of the calyx of the physalis on DPPH reaches 96.79+/-2.09 percent, the antioxidation effect is good, and the DNA damage caused by ultraviolet irradiation can be reduced.
2. According to the invention, the alcohol phosphate and the cetyl palmitate are added, the alcohol phosphate and the cetyl palmitate are extremely mild surfactants, the stearyl glycyrrhetinate has the effects of relieving and resisting the conditioning of the sensitive skin, the soybean lecithin plays a key role in maintaining the physiological activity of a biological film and the normal metabolism of an organism, and is very important in beautifying the skin, and the chrysanthemum extract can resist bacteria and inflammation, condition the skin and prevent acne, and has a quite good inhibition effect on skin inflammation, so that the effect is better when the physalis alkekengi extract is applied to skin care.
Detailed Description
The following description of the embodiments of the present invention will be made with reference to specific embodiments, and it is apparent that the embodiments described are only some, but not all embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1:
the invention provides a sour slurry extract for skin care, which comprises the following raw materials in parts by weight: 60 parts of berry extract, 30 parts of calyx extract, 3 parts of alcohol phosphate, 3 parts of soybean lecithin, 2 parts of cetyl palmitate, 2 parts of stearyl glycyrrhetinate and 1 part of chrysanthemum extract.
In a preferred embodiment, the alcohol phosphate is a C12-13 alcohol phosphate.
In a preferred embodiment, the method for preparing the acid pulp extract for skin care comprises the following steps:
step one: preparing berry extract, cleaning and drying the sour slurry berries, crushing and screening the dried berries, placing the screened berries in an extraction kettle, performing supercritical extraction on the berries by using carbon dioxide fluid, and obtaining the berry extract for later use after extraction and separation;
step two: preparing a calyx extract, namely separating the calyx from the acid pulp, drying, crushing and screening the selected calyx, placing the screened calyx in an extraction kettle, performing supercritical extraction on the calyx by using carbon dioxide fluid, and extracting and separating to obtain the calyx extract for later use;
step three: preparing chrysanthemum extract, namely weighing white flowers, chamomile and chrysanthemum, crushing to prepare ultrafine powder of the white flowers Huang Chun, adding an extractant into the ultrafine powder of the Bai Huahuang chamomile, heating and refluxing for 3 times, filtering and collecting filtrate, and concentrating the filtrate under reduced pressure to obtain the chrysanthemum extract;
step four: the preparation of the physalis alkekengi extract, namely uniformly mixing the berry extract obtained in the first step, the calyx extract obtained in the second step and the chrysanthemum extract obtained in the third step under the assistance of ultrasonic waves, then sequentially adding alcohol phosphate, soybean lecithin, cetyl palmitate and stearyl glycyrrhetinate, and uniformly stirring and mixing to obtain the physalis alkekengi extract for skin care.
In a preferred embodiment, the flow rate of carbon dioxide in the supercritical extraction in the first step is 20L/h, the extraction pressure in the extraction kettle is 30MPa, the extraction temperature is 43 ℃, and the extraction time is 2.5h.
In a preferred embodiment, the flow rate of carbon dioxide in the supercritical extraction in the second step is 22L/h, the extraction pressure in the extraction kettle is 33MPa, the extraction temperature is 43 ℃, and the extraction time is 3h.
In a preferred embodiment, the crushing and screening in the first step is performed by using a No. 8 sieve, and the crushing and screening in the second step is performed by using a No. 6 sieve.
In a preferred embodiment, the temperature of the heating reflux in the third step is 65 ℃ and the time of the heating reflux is 2 hours.
In a preferred embodiment, the ultrasonic frequency of the ultrasonic wave in the fourth step is 35KHz, and the ultrasonic auxiliary mixing time is 1.5h.
Example 2:
unlike example 1, a physalis alkekengi extract for skin care comprises the following raw materials in parts by weight: 70 parts of berry extract, 35 parts of calyx extract, 4.5 parts of alcohol phosphate, 4.5 parts of soybean lecithin, 3.5 parts of cetyl palmitate, 3.5 parts of stearyl glycyrrhetinate and 3 parts of chrysanthemum extract.
Example 3:
unlike example 1, a physalis alkekengi extract for skin care comprises the following raw materials in parts by weight: 80 parts of berry extract, 40 parts of calyx extract, 6 parts of alcohol phosphate, 6 parts of soybean lecithin, 5 parts of cetyl palmitate, 5 parts of stearyl glycyrrhetinate and 5 parts of chrysanthemum extract.
Example 4:
the invention provides a sour slurry extract for skin care, which comprises the following raw materials in parts by weight: 30 parts of a calyx extract, 3 parts of alcohol phosphate, 3 parts of soybean lecithin, 2 parts of cetyl palmitate, 2 parts of stearyl glycyrrhetinate and 1 part of a chrysanthemum extract.
In a preferred embodiment, the alcohol phosphate is a C12-13 alcohol phosphate.
In a preferred embodiment, the method for preparing the acid pulp extract for skin care comprises the following steps:
step one: preparing a calyx extract, separating calyx from acid pulp, drying, crushing and screening the selected calyx, placing the screened calyx in an extraction kettle, performing supercritical extraction on the calyx by using carbon dioxide fluid, and extracting and separating to obtain a calyx extract for later use
Step two: preparing chrysanthemum extract, namely weighing white flowers, chamomile and chrysanthemum, crushing to prepare ultrafine powder of the white flowers Huang Chun, adding an extractant into the ultrafine powder of the Bai Huahuang chamomile, heating and refluxing for 3 times, filtering and collecting filtrate, and concentrating the filtrate under reduced pressure to obtain the chrysanthemum extract;
step three: the preparation of the physalis alkekengi extract obtained in the first step and the chrysanthemum extract obtained in the second step are uniformly mixed under the assistance of ultrasonic waves, isoparaffin, alcohol phosphate, soybean lecithin, cetyl palmitate, stearyl glycyrrhetinate, sodium ascorbate and aminopropanediol are sequentially added, and the physalis alkekengi extract for skin care is obtained after uniform stirring and mixing.
In a preferred embodiment, the flow rate of carbon dioxide in the supercritical extraction in the first step is 22L/h, the extraction pressure in the extraction kettle is 33MPa, the extraction temperature is 43 ℃, and the extraction time is 3h.
In a preferred embodiment, the crushing and screening in the first step is performed by using a No. 6 screen.
In a preferred embodiment, the temperature of the heating reflux in the second step is 65 ℃ and the time of the heating reflux is 2 hours.
In a preferred embodiment, the ultrasonic frequency of the ultrasonic wave in the third step is 35KHz, and the ultrasonic auxiliary mixing time is 1.5h.
Example 5:
the invention provides a sour slurry extract for skin care, which comprises the following raw materials in parts by weight: 60 parts of berry extract, 3 parts of alcohol phosphate, 3 parts of soybean lecithin, 2 parts of cetyl palmitate, 2 parts of stearyl glycyrrhetinate and 1 part of chrysanthemum extract.
In a preferred embodiment, the alcohol phosphate is a C12-13 alcohol phosphate.
In a preferred embodiment, the method for preparing the acid pulp extract for skin care comprises the following steps:
step one: preparing berry extract, cleaning and drying the sour slurry berries, crushing and screening the dried berries, placing the screened berries in an extraction kettle, performing supercritical extraction on the berries by using carbon dioxide fluid, and obtaining the berry extract for later use after extraction and separation;
step two: preparing chrysanthemum extract, namely weighing white flowers, chamomile and chrysanthemum, crushing to prepare ultrafine powder of the white flowers Huang Chun, adding an extractant into the ultrafine powder of the Bai Huahuang chamomile, heating and refluxing for 3 times, filtering and collecting filtrate, and concentrating the filtrate under reduced pressure to obtain the chrysanthemum extract;
step three: the preparation of the physalis alkekengi extract, namely uniformly mixing the berry extract obtained in the first step, the calyx extract obtained in the second step and the chrysanthemum extract obtained in the third step under the assistance of ultrasonic waves, then sequentially adding alcohol phosphate, soybean lecithin, cetyl palmitate and stearyl glycyrrhetinate, and uniformly stirring and mixing to obtain the physalis alkekengi extract for skin care.
In a preferred embodiment, the flow rate of carbon dioxide in the supercritical extraction in the first step is 20L/h, the extraction pressure in the extraction kettle is 30MPa, the extraction temperature is 43 ℃, and the extraction time is 2.5h.
In a preferred embodiment, the crushing and screening in the first step is performed by using a No. 8 screen.
In a preferred embodiment, the temperature of the heating reflux in the second step is 65 ℃ and the time of the heating reflux is 2 hours.
In a preferred embodiment, the ultrasonic frequency of the ultrasonic wave in the third step is 35KHz, and the ultrasonic auxiliary mixing time is 1.5h.
Comparative example:
the invention provides a sour slurry extract for skin care, which comprises the following raw materials in parts by weight: 60 parts of berry extract, 30 parts of calyx extract, 2 parts of cetyl palmitate and 2 parts of stearyl glycyrrhetinate.
In a preferred embodiment, the alcohol phosphate is a C12-13 alcohol phosphate.
In a preferred embodiment, the method for preparing the acid pulp extract for skin care comprises the following steps:
step one: preparing berry extract, cleaning and drying the sour slurry berries, crushing and screening the dried berries, placing the screened berries in an extraction kettle, performing supercritical extraction on the berries by using carbon dioxide fluid, and obtaining the berry extract for later use after extraction and separation;
step two: preparing a calyx extract, namely separating the calyx from the acid pulp, drying, crushing and screening the selected calyx, placing the screened calyx in an extraction kettle, performing supercritical extraction on the calyx by using carbon dioxide fluid, and extracting and separating to obtain the calyx extract for later use;
step three: the preparation of the physalis alkekengi extract, namely uniformly mixing the berry extract obtained in the first step and the calyx extract obtained in the second step under the assistance of ultrasonic waves, sequentially adding alcohol phosphate, soybean lecithin, cetyl palmitate and stearyl glycyrrhetinate, and uniformly stirring and mixing to obtain the physalis alkekengi extract for skin care.
In a preferred embodiment, the flow rate of carbon dioxide in the supercritical extraction in the first step is 20L/h, the extraction pressure in the extraction kettle is 30MPa, the extraction temperature is 43 ℃, and the extraction time is 2.5h.
In a preferred embodiment, the flow rate of carbon dioxide in the supercritical extraction in the second step is 22L/h, the extraction pressure in the extraction kettle is 33MPa, the extraction temperature is 43 ℃, and the extraction time is 3h.
In a preferred embodiment, the crushing and screening in the first step is performed by using a No. 8 sieve, and the crushing and screening in the second step is performed by using a No. 6 sieve.
In a preferred embodiment, the ultrasonic frequency of the ultrasonic wave in the third step is 35KHz, and the ultrasonic auxiliary mixing time is 1.5h.
Respectively taking the acid pulp extracts prepared in the examples 1-5 as an experiment group 1, an experiment group 2, an experiment group 3, an experiment group 4 and an experiment group 5, adopting the acid pulp extracts produced in the comparative example as a control group for testing, adopting an oxford cup method to pour 20ml of LB culture medium into each plate, taking 200ul of bacterial solutions of staphylococcus aureus, escherichia coli and bacillus subtilis respectively on the culture medium after solidification by using a pipette, and then preparing 40mg/ml of tested liquid of the selected acid pulp extracts by using acetone for measuring the antibacterial zone by adding the tested liquid into oxford cups respectively; oxidation resistance was tested using DPPH radical scavenging method and the test results are shown in table 1:
TABLE 1
As can be seen from Table I, the acid pulp extract obtained by the invention has better antibacterial effect and better oxidation resistance when being used for skin care, compared with the embodiment 1, the embodiment 4 has obviously reduced antibacterial effect without berry extract and slightly reduced oxidation resistance, the embodiment 5 has slightly reduced antibacterial effect without calyx extract compared with the embodiment 1, and obviously reduced oxidation resistance. According to the invention, the alcohol phosphate and the cetyl palmitate are added, the alcohol phosphate and the cetyl palmitate are extremely mild surfactants, the stearyl glycyrrhetinate has the effects of relieving and resisting the conditioning of the sensitive skin, the soybean lecithin plays a key role in maintaining the physiological activity of a biological film and the normal metabolism of an organism, and is very important in beautifying the skin, and the chrysanthemum extract can resist bacteria and inflammation, condition the skin and prevent acne, and has a quite good inhibition effect on skin inflammation, so that the effect is better when the physalis alkekengi extract is applied to skin care.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Finally, it should be noted that: the foregoing description is only a preferred embodiment of the present invention, and the present invention is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present invention has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (8)

1. A sour slurry extract for skin care, characterized in that: the material comprises the following raw materials in parts by weight: 60-80 parts of berry extract, 30-40 parts of calyx extract, 3-6 parts of alcohol phosphate, 3-6 parts of soybean lecithin, 2-5 parts of cetyl palmitate, 2-5 parts of stearyl glycyrrhetinate and 1-5 parts of chrysanthemum extract;
the preparation method of the physalis alkekengi extract for skin care comprises the following steps:
step one: preparing berry extract, cleaning and drying the sour slurry berries, crushing and screening the dried berries, placing the screened berries in an extraction kettle, performing supercritical extraction on the berries by using carbon dioxide fluid, and obtaining the berry extract for later use after extraction and separation;
step two: preparing a calyx extract, namely separating the calyx from the acid pulp, drying, crushing and screening the selected calyx, placing the screened calyx in an extraction kettle, performing supercritical extraction on the calyx by using carbon dioxide fluid, and extracting and separating to obtain the calyx extract for later use;
step three: preparing flos Chrysanthemi extract, weighing flos Chrysanthemi, pulverizing to obtain flos Chrysanthemi superfine powder, adding extractant into flos Chrysanthemi superfine powder, heating and reflux extracting for 3-4 times, filtering to collect filtrate, and concentrating the filtrate under reduced pressure to obtain flos Chrysanthemi extract;
step four: preparing a physalis alkekengi extract, namely uniformly mixing the berry extract obtained in the first step, the calyx extract obtained in the second step and the chrysanthemum extract obtained in the third step under the assistance of ultrasonic waves, sequentially adding alcohol phosphate, soybean lecithin, cetyl palmitate and stearyl glycyrrhetinate, and uniformly stirring and mixing to obtain the physalis alkekengi extract for skin care;
the alcohol phosphate is C12-13 alcohol phosphate.
2. A physalis alkekengi extract for skin care according to claim 1, characterized in that: the material comprises the following raw materials in parts by weight: 65-75 parts of berry extract, 33-37 parts of calyx extract, 4-5 parts of alcohol phosphate, 4-5 parts of soybean lecithin, 3-4 parts of cetyl palmitate, 3-4 parts of stearyl glycyrrhetinate and 2-4 parts of chrysanthemum extract.
3. A physalis alkekengi extract for skin care according to claim 1, characterized in that: the material comprises the following raw materials in parts by weight: 70 parts of berry extract, 35 parts of calyx extract, 4.5 parts of alcohol phosphate, 4.5 parts of soybean lecithin, 3.5 parts of cetyl palmitate, 3.5 parts of stearyl glycyrrhetinate and 3 parts of chrysanthemum extract.
4. A physalis alkekengi extract for skin care according to claim 1, characterized in that: the flow of the carbon dioxide in the supercritical extraction in the first step is 17-23L/h, the extraction pressure in the extraction kettle is 28-32MPa, the extraction temperature is 40-45 ℃, and the extraction time is 2-3h.
5. A physalis alkekengi extract for skin care according to claim 1, characterized in that: the flow of carbon dioxide in the supercritical extraction in the second step is 20-24L/h, the extraction pressure in the extraction kettle is 30-35MPa, the extraction temperature is 40-45 ℃, and the extraction time is 2-4h.
6. A physalis alkekengi extract for skin care according to claim 1, characterized in that: the first step adopts a No. 5-9 sieve for screening during crushing and screening, and the second step adopts a No. 4-8 sieve for screening during crushing and screening.
7. A physalis alkekengi extract for skin care according to claim 1, characterized in that: and in the third step, the heating reflux temperature is 60-70 ℃, and the heating reflux time is 1-3h.
8. A physalis alkekengi extract for skin care according to claim 1, characterized in that: the ultrasonic frequency of the ultrasonic wave in the step four is 25-50KHz, and the auxiliary mixing time of the ultrasonic wave is 1-2h.
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102633861A (en) * 2012-04-23 2012-08-15 南京泽朗医药科技有限公司 Preparation method of physalin B
CN105979955A (en) * 2013-12-12 2016-09-28 凯敏工业公司 Personal care products containing extracts of Chinese lantern (physalis alkekengi)
CN108295149A (en) * 2018-03-06 2018-07-20 佛山职业技术学院 Flavones extracting process in a kind of mushroom ma
CN110721101A (en) * 2019-10-17 2020-01-24 广州市瓷颜化妆品有限公司 Self-prepared two-component essence cream and preparation method thereof
CN111840408A (en) * 2020-04-30 2020-10-30 云南贝泰妮生物科技集团股份有限公司 A method for preparing herba Oxalidis Corniculatae extract with antiinflammatory effect and quality control method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102633861A (en) * 2012-04-23 2012-08-15 南京泽朗医药科技有限公司 Preparation method of physalin B
CN105979955A (en) * 2013-12-12 2016-09-28 凯敏工业公司 Personal care products containing extracts of Chinese lantern (physalis alkekengi)
CN108295149A (en) * 2018-03-06 2018-07-20 佛山职业技术学院 Flavones extracting process in a kind of mushroom ma
CN110721101A (en) * 2019-10-17 2020-01-24 广州市瓷颜化妆品有限公司 Self-prepared two-component essence cream and preparation method thereof
CN111840408A (en) * 2020-04-30 2020-10-30 云南贝泰妮生物科技集团股份有限公司 A method for preparing herba Oxalidis Corniculatae extract with antiinflammatory effect and quality control method thereof

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