CN115551891A - 用于治疗癌症的嵌合抗原受体及相关方法和组合物 - Google Patents

用于治疗癌症的嵌合抗原受体及相关方法和组合物 Download PDF

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Publication number
CN115551891A
CN115551891A CN202180032322.2A CN202180032322A CN115551891A CN 115551891 A CN115551891 A CN 115551891A CN 202180032322 A CN202180032322 A CN 202180032322A CN 115551891 A CN115551891 A CN 115551891A
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region
polypeptide
light chain
heavy chain
seq
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伊冯娜·于-轩·陈
陈希敏
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/42—Cancer antigens
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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    • A61K2239/47—Brain; Nervous system
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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CN202180032322.2A 2020-03-02 2021-03-02 用于治疗癌症的嵌合抗原受体及相关方法和组合物 Pending CN115551891A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062984139P 2020-03-02 2020-03-02
US62/984,139 2020-03-02
US202063084138P 2020-09-28 2020-09-28
US63/084,138 2020-09-28
PCT/US2021/020511 WO2021178430A2 (en) 2020-03-02 2021-03-02 Chimeric antigen receptors and related methods and compositions for the treatment of cancer

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CN115551891A true CN115551891A (zh) 2022-12-30

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US (2) US12595311B2 (https=)
EP (1) EP4114861A4 (https=)
JP (1) JP7834345B2 (https=)
KR (1) KR20220149606A (https=)
CN (1) CN115551891A (https=)
AU (1) AU2021232512A1 (https=)
CA (1) CA3174575A1 (https=)
WO (1) WO2021178430A2 (https=)

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Publication number Priority date Publication date Assignee Title
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
WO2020160156A2 (en) 2019-01-30 2020-08-06 Immutics, Inc. Anti-gal3 antibodies and uses thereof
EP4157338A4 (en) 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
WO2025100965A1 (ko) * 2023-11-07 2025-05-15 주식회사 박셀바이오 EphA2를 타겟하는 개선된 특성을 갖는 친수성 모노바디 및 이를 포함하는 다중특이적 키메라 항원 수용체 및 조작된 면역세포

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CN1835977A (zh) * 2003-08-14 2006-09-20 默克专利有限公司 Cd20－结合多肽组合物
US20190106501A1 (en) * 2016-03-18 2019-04-11 Fred Hutchinson Cancer Research Center Compositions and methods for cd20 immunotherapy
CN110741016A (zh) * 2017-04-26 2020-01-31 优瑞科生物技术公司 嵌合抗体/t-细胞受体构筑体及其用途

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US20050037420A1 (en) 2001-09-14 2005-02-17 Mei-Yun Zhang Immunoglobulin having particular framework scaffold and methods of making and using
KR20230148844A (ko) 2016-03-29 2023-10-25 유니버시티 오브 써던 캘리포니아 암을 표적하는 키메라 항원 수용체
ES2981703T3 (es) 2016-09-02 2024-10-10 Lentigen Tech Inc Composiciones y métodos para tratar cáncer con DuoCars
EP3529268B1 (en) 2016-10-19 2025-02-26 The Scripps Research Institute Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof
CA3069527A1 (en) 2017-07-12 2019-01-17 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for treatment of cancers harboring an h3k27m mutation
WO2019067805A1 (en) 2017-09-27 2019-04-04 University Of Southern California NEW PLATFORMS FOR CO-STIMULATION, NEW CAR DESIGNS AND OTHER IMPROVEMENTS FOR ADOPTIVE CELL THERAPY
CN113924103B (zh) * 2019-03-06 2025-02-14 莱蒂恩技术公司 用于用自驱动的嵌合抗原受体来治疗癌症的组合物和方法
KR20230153529A (ko) 2021-02-19 2023-11-06 프리트 엠. 쇼드하리 다양한 면역세포를 위한 단일사슬 및 다중사슬 합성 항원 수용체

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN1835977A (zh) * 2003-08-14 2006-09-20 默克专利有限公司 Cd20－结合多肽组合物
US20190106501A1 (en) * 2016-03-18 2019-04-11 Fred Hutchinson Cancer Research Center Compositions and methods for cd20 immunotherapy
CN110741016A (zh) * 2017-04-26 2020-01-31 优瑞科生物技术公司 嵌合抗体/t-细胞受体构筑体及其用途

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JP7834345B2 (ja) 2026-03-24
JP2023516067A (ja) 2023-04-17
US20230084763A1 (en) 2023-03-16
CA3174575A1 (en) 2021-09-10
WO2021178430A3 (en) 2021-10-07
KR20220149606A (ko) 2022-11-08
AU2021232512A1 (en) 2022-09-29
US12479923B2 (en) 2025-11-25
US12595311B2 (en) 2026-04-07
WO2021178430A2 (en) 2021-09-10
EP4114861A4 (en) 2024-05-08
US20250109213A1 (en) 2025-04-03
EP4114861A2 (en) 2023-01-11

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