CN115532525A - Sample application device for accurately generating parallel micro-droplet array - Google Patents
Sample application device for accurately generating parallel micro-droplet array Download PDFInfo
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- CN115532525A CN115532525A CN202211069858.4A CN202211069858A CN115532525A CN 115532525 A CN115532525 A CN 115532525A CN 202211069858 A CN202211069858 A CN 202211069858A CN 115532525 A CN115532525 A CN 115532525A
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- array
- micro
- accommodating cavity
- capillary
- spray head
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C5/00—Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work
- B05C5/02—Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work the liquid or other fluent material being discharged through an outlet orifice by pressure, e.g. from an outlet device in contact or almost in contact, with the work
- B05C5/0208—Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work the liquid or other fluent material being discharged through an outlet orifice by pressure, e.g. from an outlet device in contact or almost in contact, with the work for applying liquid or other fluent material to separate articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C11/00—Component parts, details or accessories not specifically provided for in groups B05C1/00 - B05C9/00
- B05C11/10—Storage, supply or control of liquid or other fluent material; Recovery of excess liquid or other fluent material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C5/00—Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work
- B05C5/02—Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work the liquid or other fluent material being discharged through an outlet orifice by pressure, e.g. from an outlet device in contact or almost in contact, with the work
- B05C5/027—Coating heads with several outlets, e.g. aligned transversally to the moving direction of a web to be coated
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a sample application device for accurately generating a parallel micro-droplet array, which comprises a spray head, a micro-droplet array generating assembly arranged in the spray head and a power assembly for applying downward impact force to the micro-droplet array generating assembly, wherein the power assembly is used for driving the micro-droplet array generating assembly to rotate; wherein: the micro-droplet array generating component comprises an array sample application mechanism, a supporting frame, an elastic piece and a punching platform; the array sample application mechanism comprises a plurality of capillary needles which are arranged in an array manner, a liquid storage pipe for sample application to the capillary needles and a connecting hose for connecting the capillary needles and the liquid storage pipe; the capillary needle in the array spotting mechanism can generate capillary action, so that the liquid in the liquid storage pipe is introduced into the capillary needle through the capillary action, an additional sample introduction power source is not needed, the structure is simple, and the operation is convenient. In addition, the device has simple structure and low manufacturing cost, can realize different solution samples while effectively avoiding cross contamination, and can realize large-area and high-density manufacture of the microarray chip.
Description
Technical Field
The invention belongs to the technical field of biology, and particularly relates to a spotting device for accurately generating a parallel micro-droplet array.
Background
The sample application head that the sample application appearance adopted in the market at present is mainly with contact sample application needle, and contact sample application has higher reagent cross contamination's risk and the fragile of sample application needle, the preparation inefficiency of microarray chip under the condition of repeated sample application. The non-contact sample application process can be independent, and the problems of pollution of a contact sample application fork, damage of a sample application needle touching a substrate and the like can be better solved
In the production process of some medical consumables and biological products, some nano-upgraded or pico-upgraded micro-droplets need to be added or fixed on the surface of the product. In the actual sample application process, the sample application process often needs to correspond to a plurality of different reagents, and meanwhile, the rapid sample application needs to be realized, so that the cross contamination among different reagents is reduced, the sample application cost is reduced, and the sample application efficiency is improved. The existing equipment is difficult to achieve the purposes at the same time.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a spotting device for accurately generating a parallel micro-droplet array, which has simple structure and low manufacturing cost, can realize spotting of different solution samples while effectively avoiding cross contamination, and can realize large-area and high-density manufacturing of a micro-array chip.
In order to achieve the purpose, the invention adopts the technical scheme that:
a spotting device for accurately generating a parallel micro-droplet array comprises a spray head, a micro-droplet array generating assembly arranged in the spray head and a power assembly for applying downward impact force to the micro-droplet array generating assembly; wherein:
the sprayer comprises a sprayer lower shell and a sprayer upper shell, connecting holes are formed in the periphery of the top surface of the sprayer lower shell, a connecting column is fixed on the bottom surface of the sprayer upper shell, and the connecting column is in interference fit with the connecting holes; the middle part of the lower shell of the spray head is provided with a first containing cavity, and the bottom of the lower shell of the spray head is provided with a spray head through hole communicated with the first containing cavity; a pair of symmetrical second accommodating cavities is formed in two sides of the upper part of the upper shell of the spray head, and a third accommodating cavity is formed in the middle of the lower part of the upper shell of the spray head; a fourth accommodating cavity is formed in the middle of the upper part of the upper shell of the spray head and communicated with the third accommodating cavity; furthermore, the fourth accommodating cavity is communicated with the third accommodating cavity through a connecting channel, the aperture of the connecting channel is smaller than that of the fourth accommodating cavity, and the connecting channel is used for a power output end in the power assembly to penetrate through so as to exert a downward action on a micro-droplet array generating assembly below; meanwhile, the aperture of the connecting channel is smaller than that of the fourth accommodating cavity, so that the power assembly can be stably installed in the fourth accommodating cavity, and the stability of the position between the power assembly and the micro liquid drop array generating assembly is kept.
The micro-droplet array generating component comprises an array sample application mechanism, a supporting frame, an elastic piece and a punching platform; the array sample application mechanism comprises a plurality of capillary needles arranged in an array, a liquid storage pipe for injecting samples to the capillary needles and a connecting hose for connecting the capillary needles and the liquid storage pipe; the capillary needle is arranged in a space formed by splicing the first accommodating cavity and the third accommodating cavity through the support frame, and the elastic element is positioned between the support frame and the lower shell of the spray head so as to enable the support frame and the lower shell of the spray head to be in elastic connection; furthermore, a plurality of positioning holes which are arranged in an array are arranged in the supporting frame, and the capillary needles are fixed in the positioning holes. The liquid storage pipe is arranged in the second accommodating cavity, and the upper shell of the spray head is provided with a plurality of through holes at the bottom of the second accommodating cavity for the connection hose to pass through; the punching platform is positioned above the supporting frame and below the power assembly and used for conducting downward action generated by the power assembly. Furthermore, the punching table comprises a punching table body and a positioning column fixed in the middle of the top surface of the punching table body, and the positioning column is positioned at the lower part of the connecting channel; the lower part of the punching platform body is a hollow cavity used for accommodating the capillary needle.
Preferably, the elastic member is a spring; it should be noted that, besides the spring, the elastic member may also be other elastic bodies with certain elasticity and compressibility, such as rubber, which can achieve the purpose of the present invention.
In one scheme, the power assembly is an electromagnetic power assembly and comprises an electromagnet shell and an electromagnet core positioned in the middle of the electromagnet shell, the electromagnet shell is installed in the fourth accommodating cavity, and when the electromagnet core moves downwards, the electromagnet core can enter the connecting channel downwards and simultaneously exert a downward acting force on the punching table; an electromagnet pressing cover used for fixing the electromagnet shell is installed at the top of the upper shell of the spray head. Preferably, the electromagnet pressing cover is connected with the upper shell of the spray head through a screw. It should be noted that the power assembly may also be actuated by a piezoelectric column, a vibration motor, or the like, and any device that can provide a stable downward impact force may be applied to implement the function of the power assembly in the present invention.
Compared with the prior art, the beneficial effects of the utility model are that:
(1) The capillary needle in the array spotting mechanism in the spotting device provided by the invention can generate capillary action, so that the liquid in the liquid storage pipe is injected into the capillary needle through the capillary action, an additional injection power source is not needed, the structure is simple, and the operation is convenient.
(2) The capillary needles are arranged in an array, so that multiple samples can be simultaneously sampled, and the sample application efficiency is high; in addition, different capillary needles are independently injected through liquid storage tubes connected with the capillary needles, and cross contamination is avoided.
(3) The capillary needle, the liquid storage tube and other components in the array spotting mechanism are independent from each other, when one component is damaged, the component can be independently replaced without influencing other components, and the maintenance difficulty and the maintenance cost of the device can be obviously reduced.
(4) The sample application device provided by the invention has the advantages of small and simple integral structure and low manufacturing cost, and effectively reduces the preparation cost of the microarray chip.
Drawings
FIG. 1 is a schematic view of the construction of a spotting device provided by the present invention;
FIG. 2 is a cross-sectional view of FIG. 1;
FIG. 3 is a schematic perspective view of the upper housing of the showerhead;
FIG. 4 is a schematic structural view of the nozzle of FIG. 1 with the upper housing removed;
FIG. 5 is an exploded view of FIG. 1;
fig. 6 is a schematic diagram of capillary needle droplet formation.
Reference numerals are as follows: 1-lower nozzle shell, 101-first accommodating cavity, 102-nozzle through hole, 103-connecting hole, 2-upper nozzle shell, 201-second accommodating cavity, 202-third accommodating cavity, 203-fourth accommodating cavity, 204-connecting channel, 205-through hole, 206-connecting column, 3-power assembly, 301-electromagnet shell, 302-electromagnet iron core, 303-electromagnet pressing cover, 304-screw, 401-capillary needle, 402-liquid storage tube, 403-connecting hose, 404-hose connector, 5-support frame, 6-elastic piece, 7-punching table, 701-punching table body, 702-positioning column, 703-cavity and 8-positioning hole.
Detailed Description
The present invention will be further described with reference to the following examples so that those skilled in the art can better understand the present invention and can practice the present invention, but the examples are not intended to limit the present invention.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the referenced devices or elements must have a specific orientation, be constructed and operated in a specific orientation, and thus, are not to be construed as limiting the present invention. The terms "first," "second," "third," "fourth," and the like herein do not denote any particular quantity or order, but rather are used to distinguish one element from another.
In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," "fixed," and the like are to be construed broadly and can include, for example, fixed connections, detachable connections, or integral connections; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood according to specific situations by those of ordinary skill in the art.
Referring to fig. 1 to 5, a spotting device for precisely generating a parallel micro-droplet array includes a nozzle, a micro-droplet array generating assembly installed inside the nozzle, and a power assembly for applying a downward impact force to the micro-droplet array generating assembly; wherein:
the sprayer comprises a sprayer lower shell 1 and a sprayer upper shell 2, connecting holes 103 are formed in the periphery of the top surface of the sprayer lower shell 1, a connecting column 206 is fixed on the bottom surface of the sprayer upper shell, and the connecting column 206 is in interference fit with the connecting holes 103 to realize the assembly of the sprayer lower shell 1 and the sprayer upper shell 2; the lower shell of the spray head and the upper shell of the spray head can be prepared through 3D printing. The middle part of the lower sprayer shell 1 is provided with a first accommodating cavity 101, and the bottom of the lower sprayer shell 1 is provided with a sprayer through hole 102 communicated with the first accommodating cavity; a pair of symmetrical second accommodating cavities 201 are formed in two sides of the upper part of the spray head upper shell 2, and a third accommodating cavity 202 is formed in the middle of the lower part of the spray head upper shell; a fourth accommodating cavity 203 is formed in the middle of the upper part of the upper shell of the spray head, and the fourth accommodating cavity 203 is communicated with the third accommodating cavity 202; further, the fourth accommodating cavity 203 is communicated with the third accommodating cavity 202 through a connecting channel 204, the aperture of the connecting channel 204 is smaller than that of the fourth accommodating cavity 203, and the connecting channel 204 is used for a power output end in the power assembly 3 to pass through, so that a downward action is exerted on a micro-droplet array generating assembly below; meanwhile, the aperture of the connecting channel is smaller than that of the fourth accommodating cavity, so that the power assembly can be stably installed in the fourth accommodating cavity, and the stability of the position between the power assembly and the micro-droplet array generating assembly is kept.
The micro-droplet array generating component comprises an array sample application mechanism, a support frame 5, an elastic piece 6 and a punching platform 7; the array spotting mechanism comprises a plurality of capillary needles 401 arranged in an array, a liquid storage tube 402 for feeding samples to the capillary needles, and a connecting hose 403 for connecting the capillary needles and the liquid storage tube; the connection position of the connection hose 403 and the capillary needle 401 can be connected through a hose connector 404, and both the connection hose 403 and the hose connector 404 can be silica gel hoses; the capillary needle can be capillary glass needle, which can be drawn by commercially available capillary glass needle through needle drawing instrument, and those skilled in the art can draw capillary glass needle with different sizes according to actual application requirements. When sample application is carried out, a liquid storage pipe can be filled with solution through a liquid transfer device and other devices, and the solution can flow into the capillary needle from the connecting hose through the capillary action because the capillary needle can generate the capillary action. In the structure shown in fig. 5, the number of the capillary needles is 16, the number of the connecting hoses is 16, and only two hoses are drawn for illustration in order to simplify the structure drawing; for those skilled in the art, the specific number of the capillary needles can be selected according to actual needs. The capillary needle 401 is installed in a space formed by splicing the first accommodating cavity 101 and the third accommodating cavity 202 through a support frame, furthermore, a plurality of positioning holes 8 which are arranged in an array are formed in the support frame 5, the capillary needle 401 is fixed in the positioning holes 8, namely the capillary needle 401 is installed on the support frame 5 through the positioning holes 8, and the support frame can be made of an acrylic plate by laser cutting; the elastic piece 6 is positioned between the support frame 5 and the lower shell 1 of the spray head, so that the support frame 5 and the lower shell 1 of the spray head are elastically connected, and the elastic piece 6 can be a spring; it should be noted that, besides the spring, the elastic member 6 may also be an elastic body with certain elasticity, such as rubber, which can achieve the object of the present invention. The liquid storage tube 402 is arranged in the second accommodating cavity 201, and the upper shell 2 of the spray head is provided with a plurality of through holes 205 at the bottom of the second accommodating cavity 201 for the connecting hose 403 to pass through; the punching platform 7 is positioned above the supporting frame 5 and below the power assembly 3 and is used for conducting downward action generated by the power assembly. Preferably, the punching table 7 comprises a punching table body 701 and a positioning column 702 fixed in the middle of the top surface of the punching table body, and the positioning column 702 is located at the lower part of the connecting channel; the lower part of the stamp block body 701 is a hollow cavity 703 for accommodating the capillary needle 401.
In one embodiment, the power assembly 3 is an electromagnetic power assembly, and comprises an electromagnet housing 301 and an electromagnet core 302 positioned in the middle of the electromagnet housing, the electromagnet housing 301 is installed in the fourth accommodating cavity 203, and when the electromagnet core moves downwards, the electromagnet core 302 can enter the connecting channel 204 downwards and simultaneously exert a downward acting force on the punching table 7; an electromagnet pressing cover 303 for fixing the electromagnet outer shell 301 is installed at the top of the upper sprayer housing 2, and the electromagnet pressing cover 303 is connected with the upper sprayer housing 2 through a screw 304. The working principle of the electromagnetic power assembly is as follows: under the condition that the battery iron core is electrified, the electromagnet iron core 302 moves downwards and impacts the punching table 7 at the same time, the punching table 7 presses the whole support frame 5, and at the moment, the elastic piece 6 is compressed; then, the battery iron core is powered off, the electromagnet iron core 302 moves upwards, the elastic part 6 resets at the moment, and the support frame 5 moves upwards under the action of the elastic force of the elastic part, so that the capillary needle 401 is driven to vibrate up and down, and liquid in the capillary needle is promoted to flow out to form small liquid drops. The formation of liquid drops in the capillary needle is realized based on the principle of elastic vibration inertia, and the formation process is shown in fig. 6, wherein: the diagram A is the initial position of the capillary needle; the drawing B shows that the capillary needle moves downwards under the downward impact force of the power assembly; c, under the action of the elastic force of the elastic part, the support frame moves upwards and synchronously drives the capillary needles to move upwards, and simultaneously liquid in the capillary needles flows out from the bottom due to inertia to form liquid drops; and D, the liquid drops are dropped on the substrate to finish spotting, and simultaneously, the liquid in the liquid storage tube fills the solution into the capillary needle under the capillary action. The spotting process can be continuously completed by repeating the above actions. It should be noted that the power assembly may also be actuated by a piezoelectric column, a vibration motor, or the like, and any device that can cyclically provide a downward impact force may be applied to implement the function of the power assembly in the present invention.
It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (8)
1. A spotting device for accurately generating an array of parallel micro-droplets, characterized in that: comprises a spray head, a micro liquid drop array generating assembly arranged in the spray head and a power assembly used for applying downward impact force to the micro liquid drop array generating assembly; wherein:
the sprayer comprises a sprayer lower shell and a sprayer upper shell, wherein a first accommodating cavity is formed in the middle of the sprayer lower shell, and a sprayer through hole communicated with the first accommodating cavity is formed in the bottom of the sprayer lower shell; a pair of symmetrical second accommodating cavities is formed in two sides of the upper part of the upper shell of the spray head, and a third accommodating cavity is formed in the middle of the lower part of the upper shell of the spray head; a fourth accommodating cavity is formed in the middle of the upper part of the upper shell of the spray head and is communicated with the third accommodating cavity;
the micro-droplet array generating component comprises an array sample application mechanism, a supporting frame, an elastic piece and a punching platform; the array sample application mechanism comprises a plurality of capillary needles arranged in an array, a liquid storage pipe for injecting samples to the capillary needles and a connecting hose for connecting the capillary needles and the liquid storage pipe; the capillary needle is arranged in a space formed by splicing the first accommodating cavity and the third accommodating cavity through a support frame, and the elastic element is positioned between the support frame and the lower shell of the spray head; the liquid storage pipe is arranged in the second accommodating cavity, and the upper shell of the spray head is provided with a plurality of through holes at the bottom of the second accommodating cavity for the connection hose to pass through; the punching table is positioned above the supporting frame and below the power assembly and used for conducting downward action generated by the power assembly.
2. Spotting device for the precise generation of arrays of parallel micro-droplets according to claim 1 characterized in that: the fourth holds and link up through connecting channel between the chamber with the third, connecting channel's aperture is less than the fourth aperture that holds the chamber.
3. Spotting device for the precise generation of arrays of parallel micro-droplets according to claim 2 characterized in that: the power assembly is an electromagnetic power assembly and comprises an electromagnet shell and an electromagnet core positioned in the middle of the electromagnet shell, the electromagnet shell is arranged in the fourth accommodating cavity, and when the electromagnet core moves downwards, the electromagnet core can enter the connecting channel downwards and apply a downward acting force to the punching table; and an electromagnet pressing cover for fixing the electromagnet shell is arranged at the top of the upper shell of the spray head.
4. Printing device for the accurate production of arrays of parallel micro droplets according to any of claims 1 to 3, characterized in that: the punching table comprises a punching table body and a positioning column fixed in the middle of the top surface of the punching table body, and the positioning column is positioned at the lower part of the connecting channel; the lower part of the punching table body is a hollow cavity used for accommodating a capillary needle.
5. Printing device for the accurate production of arrays of parallel micro droplets according to any of claims 1 to 3, characterized in that: a plurality of positioning holes which are arranged in an array are formed in the supporting frame, and the capillary needle is fixed in the positioning holes.
6. Spotting device for the precise generation of arrays of parallel micro-droplets according to claim 1 characterized in that: the elastic piece is a spring.
7. Spotting device for the precise generation of arrays of parallel micro-droplets according to claim 1 characterized in that: the nozzle is characterized in that connecting holes are formed in the periphery of the top surface of the lower shell of the nozzle, connecting columns are fixed on the bottom surface of the upper shell of the nozzle and are in interference fit with the connecting holes.
8. Printing device for the precise generation of arrays of parallel micro-droplets according to claim 1, characterized in that: the power component is a piezoelectric column or a vibration motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211069858.4A CN115532525A (en) | 2022-09-01 | 2022-09-01 | Sample application device for accurately generating parallel micro-droplet array |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211069858.4A CN115532525A (en) | 2022-09-01 | 2022-09-01 | Sample application device for accurately generating parallel micro-droplet array |
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| Publication Number | Publication Date |
|---|---|
| CN115532525A true CN115532525A (en) | 2022-12-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211069858.4A Pending CN115532525A (en) | 2022-09-01 | 2022-09-01 | Sample application device for accurately generating parallel micro-droplet array |
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| CN (1) | CN115532525A (en) |
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- 2022-09-01 CN CN202211069858.4A patent/CN115532525A/en active Pending
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