CN115524477A - Sample detection device and method - Google Patents

Abstract

The embodiment of the application discloses sample test equipment includes: the card bin is used for accommodating a detection card containing a sample and a reagent; the colorimetric detection device comprises a colorimetric detection module and a first detection area; the impedance detection device comprises an impedance detection module and a second detection area; the turbidimetric detection device comprises a turbidimetric detection module and a third detection area; the light-emitting detection device comprises a light-emitting detection module and a fourth detection area; the horizontal guide rail assembly is used for driving the card bin to slide to the first detection area, the second detection area, the third detection area and the fourth detection area according to a time sequence; and the vertical guide rail assembly pushes the piston of the detection card to slide according to time sequence. The embodiment of the application also discloses a sample detection method. The embodiment of the application solves the technical problem of how to implement joint detection of multiple methodologies on a single sample on a single device.

Description

Sample detection device and method

Technical Field

The embodiment of the application relates to the technical field of in-vitro detection. More particularly, embodiments of the present application relate to a sample testing device and method.

Background

Conventional sample testing devices generally have only a single function, that is, a sample testing device can only perform a single item test on a sample, and may employ one or two testing methods. For example, the detection device for blood cell analysis can realize routine blood analysis by combining impedance method and colorimetric method. With the advancement of technology, the C-reactive protein, one of the specific proteins, can be detected after adding turbidimetry to it. If a sample is to be tested for more items (using principles such as impedance method, colorimetry, turbidimetry, chemiluminescence immunoassay, etc.), at least 2 or more devices are required to be configured for impedance method/colorimetry (or/and turbidimetry) test, single turbidimetry test, and chemiluminescence test, respectively. For a basic medical institution, a plurality of inspection devices are configured, and different difficulties exist in aspects such as cost, space, benefit and the like, so that inspection work cannot be well carried out.

Disclosure of Invention

The embodiment of the application provides sample detection equipment and a sample detection method, and solves the technical problem of how to implement joint detection of multiple methodologies on a single sample on single equipment. The embodiment of the application is mainly realized by the following technical schemes in many aspects:

< first aspect of embodiments of the present application >

A first aspect of embodiments of the present application provides a sample detection apparatus, including:

the card bin is used for accommodating a detection card containing a sample and a reagent;

the colorimetric detection device comprises a colorimetric detection module and a first detection area, wherein the colorimetric detection module is used for detecting a detection card in the first detection area;

the impedance detection device comprises an impedance detection module and a second detection area, wherein the impedance detection module is used for detecting a detection card in the second detection area;

the turbidimetric detection device comprises a turbidimetric detection module and a third detection area, wherein the turbidimetric detection module is used for detecting a detection card in the third detection area;

the light-emitting detection device comprises a light-emitting detection module and a fourth detection area, wherein the light-emitting detection module is used for detecting a detection card in the fourth detection area;

the card bin is connected with the horizontal guide rail assembly in a sliding mode, and slides to the first detection area, the second detection area, the third detection area and the fourth detection area on the horizontal guide rail assembly according to time sequence;

the vertical guide rail assembly pushes a piston of the detection card to slide according to time sequence;

when the card bin slides to the first detection area, the vertical guide rail assembly pushes the piston to slide to a first preset area of the detection card, so that a mixed solution of a sample and a reagent enters a colorimetric detection area of the detection card, and the colorimetric detection module performs colorimetric detection on the mixed solution;

when the card bin slides to the second detection area, the vertical guide rail assembly pushes the piston to slide to a second preset area of the detection card, so that the mixed liquid enters an impedance detection area of the detection card, and the impedance detection module performs impedance detection on the mixed liquid;

when the card bin slides to the third detection area, the vertical guide rail assembly pushes the piston to slide to a third preset area of the detection card, so that the mixed liquid enters a turbidimetric detection area of the detection card, and the turbidimetric detection module performs turbidimetric detection on the mixed liquid;

when the card bin slides to the fourth detection area, the vertical guide rail assembly pushes the piston to slide to the fourth preset area of the detection card, so that the mixed liquid enters the light-emitting detection area of the detection card, and the light-emitting detection module performs light-emitting detection on the mixed liquid.

Further, the first detection area is positioned at a first detection port of the colorimetric detection module; the second detection area is positioned at a second detection port of the impedance detection module; the third detection area is positioned at a third detection port of the turbidimetric detection module; the fourth detection area is positioned at a fourth detection port of the luminescence detection module

Further, the sample detection apparatus further comprises a control module, wherein the control module is configured to send detection signals to the impedance detection module, the colorimetric detection module, the turbidimetric detection module, and the luminescence detection module.

Further, the horizontal guide rail assembly comprises a horizontal guide rail component and a first sliding block, the first sliding block is connected with the horizontal guide rail component in a sliding mode, and the clamping bin is arranged on the first sliding block.

Further, the vertical guide rail assembly comprises a vertical guide rail component and a second sliding block, the second sliding block is connected with the vertical guide rail component in a sliding mode, and a push rod is arranged on the second sliding block and used for pushing the piston.

Further, the sample detection device further comprises a driving module, and the first slider and the second slider are respectively connected with the driving module.

Furthermore, the driving module is electrically connected with the control module, and the control module is further used for sending a control signal to the driving module.

Further, the sample detection apparatus further comprises a light shielding member and an incubation member, both of which are electrically connected to the control module.

Further, the driving module comprises a first driving member, a second driving member, a third driving member, a fourth driving member, a first transmission member, a second transmission member, a third transmission member and a fourth transmission member, wherein the first driving member is connected with the first transmission member, the first transmission member is connected with the first slider, the second driving member is connected with the second transmission member, the second transmission member is connected with the second slider, the third driving member is connected with the third transmission member, the third transmission member is connected with the light shielding member, the fourth driving member is connected with the fourth transmission member, and the fourth transmission member is connected with the blending member.

Furthermore, the sample detection equipment also comprises a base, a light shield and a support bracket, wherein one end of the support bracket is connected with the vertical guide rail assembly, and the other end of the support bracket is connected with the base; the lens hood is connected with the base to form an accommodating cavity, and the accommodating cavity is used for accommodating the card bin, the horizontal guide rail assembly, the vertical guide rail assembly, the uniformly mixing component, the light shielding component and the incubation component.

Furthermore, the sample detection device further comprises a display module, wherein the display module is electrically connected with the control module, and the display module is used for realizing the interaction between the sample detection device and a user.

Further, the sample detection device further comprises a printing module, wherein the printing module is electrically connected with the control module and is used for printing a detection result.

< second aspect of embodiments of the present application >

A second aspect of the embodiments of the present application provides a sample detection method, which is applied to the sample detection device provided in the first aspect of the embodiments of the present application, and the sample detection method includes:

the colorimetric detection module receives the first detection signal and executes colorimetric detection;

the impedance detection module receives the second detection signal and executes impedance detection;

the turbidimetry detection module receives the third detection signal and executes turbidimetry detection;

and the luminescence detection module receives the fourth detection signal and executes luminescence detection.

The beneficial effects of the embodiment of the application include:

in the prior art, the conventional sample detection equipment can only realize the detection of a single methodology on a sample, and if the detection of a plurality of methodologies is required, a plurality of detection equipment are required. In contrast, the embodiment of the present application integrates the colorimetric detection device, the impedance detection device, the turbidimetric detection device, and the luminescence detection device into one device, and the cartridge is slid to the first detection region of the colorimetric detection device, the second detection region of the impedance detection device, the third detection region of the turbidimetric detection device, and the fourth detection region of the luminescence detection device in time sequence by providing the horizontal guide rail assembly; in the corresponding detection area, the vertical guide rail assembly pushes the piston of the detection card to slide according to time sequence, so that the sample enters the detection space of the detection card corresponding to the detection area, and the corresponding item detection is realized. Based on this, the embodiment of the application can realize the joint detection of multiple items (methodologies) on a single sample on a single device.

According to the embodiment of the application, a plurality of sample detection devices for detecting samples are integrated in one device, so that the device is multipurpose, and the use cost of a user is reduced.

Because the detection card of this application embodiment is from taking reagent, can effectively avoid the problem of the bottle-opening validity period of traditional equipment reagent bottle.

The colorimetric detection device, the impedance detection device, the turbidimetric detection device, and the luminescence detection device in the embodiments of the present application may be one or more, and may also be combined as needed, which is not limited herein.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the embodiments of this application belong.

The various features and embodiments mentioned in the above aspects in relation to the embodiments of the present application may be applied to other aspects, as appropriate, mutatis mutandis. Thus, particular features in one aspect may be combined with particular features in other aspects as appropriate.

Additional advantages, objects, and features of embodiments of the application will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of embodiments of the application.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the description of the embodiments of the present application will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained according to these drawings without inventive exercise.

FIG. 1 is a block diagram of a sample testing device according to embodiments of the present disclosure in some embodiments;

FIG. 2 is a block diagram of a drive module, horizontal guide rail assembly, vertical guide rail assembly, shade member, and homogenizing member of embodiments of the present disclosure in some embodiments;

FIG. 3 is a schematic diagram of a sample testing device according to embodiments of the present disclosure in some embodiments;

FIG. 4 is a schematic structural diagram of a sample testing device according to an embodiment of the present application in further embodiments;

FIG. 5 is a schematic diagram of a sample testing device according to an embodiment of the present application in further embodiments;

FIG. 6 is a schematic structural diagram of a sample testing device according to an embodiment of the present disclosure in further embodiments;

FIG. 7 is a schematic structural view of a cartridge, a first drive member, an incubation member, a cartridge holder, and a horizontal rail assembly of embodiments of the present application in some embodiments;

FIG. 8 is a schematic illustration of a vertical rail assembly, a second drive member, a second transmission member, and a detection card in accordance with an embodiment of the present disclosure;

FIG. 9 is a schematic structural view of a shade member, a third drive member, and a third transmission member of an embodiment of the present application in some embodiments;

FIG. 10 is a schematic illustration of a mixing member, a fourth drive member, and a fourth drive member of embodiments of the present application in some embodiments;

fig. 11 is a schematic structural view of a light shield according to an embodiment of the present disclosure in some embodiments;

FIG. 12 is a flow diagram of a sample detection method of embodiments of the present application in some embodiments;

description of reference numerals:

1. a sample detection device; 10. blocking a bin; 11. detecting the card; 111. a piston; 20. a colorimetric detection device; 30. an impedance detection device; 40. a turbidimetric detection device; 50. a luminescence detection device; 60. a horizontal guide rail assembly; 61. a horizontal rail member; 62. a first slider; 70. a vertical guide rail assembly; 71. a vertical rail member; 72. a second slider; 80. a control module; 90. a display module; 100. a printing module; 110. a drive module; 120. a blending component; 130. a light shielding member; 140. an incubation member; 150. a base; 160. a light shield; 170. a support bracket; 180. a card bin bracket; 190. a housing; a1, a first driving member; b1, a second driving member; c1, a third drive member; d1, a fourth driving component; a2, a first transmission component; b2, a second transmission component; c2, a third transmission component; d2, a fourth transmission component; e1, a first detection area; e2, a second detection area; e3, a third detection area; e4, a fourth detection area.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more clearly and completely apparent, the technical solutions in the embodiments of the present application will be described below in conjunction with the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without any creative effort belong to the protection scope of the embodiments in the present application.

The terms "first", "second", "third", and "fourth", etc. in the description of the embodiments of the present application are used for distinguishing different objects, and are not used for describing a particular order of the objects. For example, the first detection area, the second detection area, the third detection area, and the fourth detection area are used to distinguish different detection areas, and are not used to describe a specific order of detection areas.

In the embodiments of the present application, words such as "exemplary" or "for example" are used to mean serving as an example, instance, or illustration. Any embodiment or design described herein as "exemplary" or "e.g.," is not necessarily to be construed as preferred or advantageous over other embodiments or designs. Rather, use of the word "exemplary" or "such as" is intended to present relevant concepts in a concrete fashion.

It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements explicitly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

The sample detection device is applied to in vitro diagnosis. The detection method of the device comprises an impedance method, a colorimetric method, a turbidimetric method and a chemiluminescence method. Impedance method and colorimetric method are commonly used for analyzing blood cells, and analyzing and detecting the number, the form and certain components of the blood cells; colorimetric methods are commonly used for biochemical project analysis; turbidimetry is commonly used for specific protein analysis; chemiluminescence methods are commonly used for immunoassays for proteins, polypeptides, and small molecules, among others.

The following further describes specific embodiments of the present application with reference to the drawings.

As shown in fig. 1 to 6, which are block diagrams of structures of a sample testing device 1 provided in an embodiment of the present application, in fig. 1, the sample testing device 1 includes:

a cartridge 10 for accommodating a test card 11 containing a sample and a reagent;

the colorimetric detection device 20 comprises a colorimetric detection module and a first detection area E1, wherein the colorimetric detection module is configured to detect the detection card 11 in the first detection area E1;

the impedance detection device 30 comprises an impedance detection module and a second detection area E2, wherein the impedance detection module is used for detecting the detection card 11 in the second detection area E2;

the turbidimetric detection device 40 comprises a turbidimetric detection module and a third detection area E3, wherein the turbidimetric detection module is used for detecting the detection card 11 in the third detection area E3;

the light-emitting detection device 50 comprises a light-emitting detection module and a fourth detection area E4, wherein the light-emitting detection module is used for detecting the detection card 11 in the fourth detection area E4;

the card bin 10 is connected with the horizontal guide rail assembly 60 in a sliding manner, and the card bin 10 slides to the first detection area E1, the second detection area E2, the third detection area E3 and the fourth detection area E4 on the horizontal guide rail assembly 60 in a time sequence;

a vertical guide assembly 70, wherein the vertical guide assembly 70 pushes the piston 111 of the detection card 11 to slide in time sequence;

when the card bin 10 slides to the first detection area E1, the vertical guide assembly 70 pushes the piston 111 to slide to a first predetermined area of the detection card 11, so that a mixed solution of a sample and a reagent enters a colorimetric detection area of the detection card 11, and the colorimetric detection module performs colorimetric detection on the mixed solution;

when the card bin 10 slides to the second detection area E2, the vertical guide assembly 70 pushes the piston 111 to slide to a second predetermined area of the detection card 11, so that the mixed liquid enters an impedance detection area of the detection card 11, and the impedance detection module performs impedance detection on the mixed liquid;

when the card bin 10 slides to the third detection area E3, the vertical guide assembly 70 pushes the piston 111 to slide to a third predetermined area of the detection card 11, so that the mixed liquid enters a turbidimetric detection area of the detection card 11, and the turbidimetric detection module performs turbidimetric detection on the mixed liquid;

when the card bin 10 slides to the fourth detection area E4, the vertical guide assembly 70 pushes the piston 111 to slide to the fourth predetermined area of the detection card 11, so that the sample mixed liquid enters the luminescence detection area of the detection card 11, and the luminescence detection module performs luminescence detection on the mixed liquid.

It should be noted that the impedance detection module includes a signal generator, a first detector, a discriminator, a threshold control unit, a counting unit, an automatic compensation unit, and a first control interface. The impedance detection module is used for classifying and counting white blood cells, red blood cells and platelets.

The colorimetric detection module comprises a first light source unit, a first lens, a first optical filter, a second detector and a second control interface. The colorimetric detection module is used for detecting the concentration of hemoglobin. The light of the light source unit is green light (the wavelength is preferably 525 nm); the lens is used for adjusting the size of the light spot, so that the size of the light spot can be matched with the area of a detection opening of the detector; the detector may employ a photoelectric sensor. Further, the light source can be a tungsten lamp and a corresponding filtering component, and light rays with corresponding wavelengths are obtained by setting the filtering component according to detection requirements.

The turbidimetric detection module comprises a second light source unit, a second lens, a second optical filter, a third detector and a third control interface. The turbidimetric detection module is used for specific protein concentration detection or biochemical detection. When the turbidimetric assay module is used for detecting the concentration of a specific protein, the second light source unit may select red light (the wavelength is preferably 630nm to 670 nm); when the turbidimetric detection module is used for biochemical detection, the second light source unit can generate light rays with specified wavelengths suitable for specific detection items by setting a filter component by using a combination of white light and the filter component. The second lens is used for adjusting the size of the light spot, so that the size of the light spot is matched with the area of a detection opening of the detector. The third detector is a photosensor.

The light emitting detection module comprises a photon detector, a photon counter and a fourth control interface. The photon detector adopts a photomultiplier or a silicon photomultiplier. The photon detector is used for collecting photon signals and obtaining the number of photons after the collected photon signals pass through the photon counter.

It should be understood that the impedance detection module, the colorimetric detection module, the turbidimetric detection module, and the luminescence detection module are not limited to the above examples, and may be set by those skilled in the art according to actual needs.

It should be noted that the dotted line in fig. 1 (i.e., the detection card 11 and the plunger 111) is only the detection object of the sample detection device 1 and does not belong to a part of the sample detection device 1.

In other embodiments, when the sample detection apparatus 1 performs colorimetric detection, the vertical guide assembly 70 may first push the piston 111 to slide to the first predetermined area of the detection card 11, so that the mixed solution enters the colorimetric detection space of the detection card 11, and then the card bin 10 slides to the first detection area E1, and the colorimetric detection module performs colorimetric detection on the mixed solution. Similarly, the sample detection device 1 can also perform the detection in the above manner when performing the impedance detection, the turbidimetric detection, and the luminescence detection.

In some embodiments, the colorimetric detection device 20 and the turbidimetric detection device 40 may be integrated on the same circuit board.

The sample detection apparatus 1 further comprises a control module 80, wherein the control module 80 is configured to send a detection signal to the impedance detection module, the colorimetric detection module, the turbidimetric detection module, and the luminescence detection module.

Control module 80 passes through first control interface with the impedance detection module electricity is connected, through the second control interface with the color comparison detection module electricity is connected, through the third control interface with the turbidimetric detection module electricity is connected, through the fourth control interface with the luminescence detection module electricity is connected.

The detection signal sent by the control module 80 to the impedance detection module is a detection signal for starting impedance detection.

The detection signal sent by the control module 80 to the colorimetric detection module is a detection signal for starting colorimetric detection.

The detection signal sent by the control module 80 to the turbidimetric detection module is a detection signal that initiates turbidimetric detection.

The detection signal sent by the control module 80 to the luminescence detection module is a detection signal for starting luminescence detection.

The sample testing device 1 further comprises a display module 90, the display module 90 is electrically connected to the control module 80, and the display module 90 is configured to enable interaction between the sample testing device 1 and a user.

The display module 90 includes a display screen, an input/output interface, a core device component, and a fifth control interface.

The input/output interface can adopt one or more modes such as touch, printing, keyboard, mouse, internet access, USB and the like.

The core device component adopts a computer (including Wi windows, macOS, L i nux devices and the like), a mobile phone (android, iOS and the like) or a tablet computer (android, iOS and the like).

The display module 90 is electrically connected to the control module 80 through the fifth control interface.

The sample testing device 1 comprises a printing module 100, wherein the printing module 100 is electrically connected with the control module 80, and the printing module 100 is used for printing a testing result.

As shown in fig. 2, the horizontal guiding rail assembly 60 includes a horizontal guiding rail member 61 and a first sliding block 62, the first sliding block 62 is slidably connected to the horizontal guiding rail member 61, and the card chamber 10 is disposed on the first sliding block 62. In other embodiments, the cartridge 10 may be coupled to the first slide 62 via a cartridge support 180.

The vertical guide assembly 70 includes a vertical guide member 71 and a second slider 72, the second slider 72 is slidably connected to the vertical guide member 71, the second slider 72 is provided with a push rod 721, and the push rod 721 is used for pushing the piston 111.

The sample testing device 1 further comprises a driving module 110, and the first slide 62 and the second slide 72 are connected to the driving module 110 respectively. The driving module 110 drives the first slider 62 to slide on the horizontal guide rail member 61, and the driving module 110 drives the second slider 72 to slide on the vertical guide rail member 71, so as to push the piston 111, so that the reagent and the sample are mixed.

The driving module 110 is electrically connected to the control module 80, and the control module 80 is further configured to send a control signal to the driving module 110.

The control signal is a signal for turning on or off the driving module 110.

The first detection area E1 is positioned at a first detection port of the colorimetric detection module; the second detection area E2 is positioned at a second detection port of the impedance detection module; the third detection area E3 is positioned at a third detection port of the turbidimetric detection module; the fourth detection area E4 is located at a fourth detection port of the light-emitting detection module.

The sample detection device 1 further comprises a mixing member 120, a light-shielding member 130 and an incubation member 140, wherein the mixing member 120, the light-shielding member 130 and the incubation member 140 are electrically connected to the control module 80.

As shown in fig. 2, 7, 8, 9 and 10, the driving module 110 includes a first driving member A1, a second driving member B1, a third driving member C1, a fourth driving member D1, a first transmission member A2, a second transmission member B2, a third transmission member C2 and a fourth transmission member D2.

The second driving component B1 is connected with the second transmission component B2 so as to drive the second transmission component B2 to rotate; the first transmission member A2 is connected to the first sliding block 62 to drive the first sliding block 62 to slide on the horizontal guide rail assembly 60.

The second driving member B1 is connected with the second transmission member B2 so as to drive the second transmission member B2 to rotate; the second transmission member B2 is connected to the second sliding block 72, and drives the second sliding block 72 to slide on the vertical guide assembly 70, so as to push the piston 111, drive the movement (flow) of the sample and the reagent, and mix the reagent and the sample.

The third driving member C1 is connected with the third transmission member C2 to drive the third transmission member C2 to rotate; the third transmission member C2 is connected to the light shielding member 130 to open or close the light shielding member 130.

The fourth driving component D1 is connected with the fourth transmission component D2 to drive the fourth transmission component D2 to rotate; the fourth transmission member D2 is connected to the kneading member 120 to start or stop the kneading member 120.

The first drive member A1, the second drive member B1, the third drive member C1 and the fourth drive member D1 are motors; the first transmission member A2, the second transmission member B2 and the fourth transmission member D2 are screws; the third transmission component C2 is a gear. In other embodiments, the first transmission member A2, the second transmission member B2, the third transmission member C2 and the fourth transmission member D2 may be other members having transmission functions, and those skilled in the art may arrange the members according to actual needs, which is not further limited by the embodiments of the present application.

The second driving member B1 drives the movement (flow) of the sample and the reagent, which means that operations such as mixing and/or dilution of the sample and the reagent in the detection card 11 are all performed in the detection card 11, and the sample detection apparatus 1 has no complicated liquid path control, thereby simplifying the apparatus and preventing cross contamination during detection.

As shown in fig. 4, 5 and 11, the sample testing device 1 further comprises a base 150, a light shield 160 and a support bracket 170, wherein one end of the support bracket 170 is connected to the vertical rail assembly 70, and the other end is connected to the base 150; the light shield 160 is connected to the base 150 to form a housing chamber, and the housing chamber is used for housing the card chamber 10, the horizontal guide rail assembly 60, the vertical guide rail assembly 70, the mixing member 120, the light shield member 130, and the incubation member 140.

As shown in fig. 3, the sample testing device 1 further comprises a housing 190, and the housing 190 is connected to the base 150, specifically, can be a screw connection or a snap connection. The connection mode of the housing 190 and the base 150 can be set by those skilled in the art according to actual requirements.

The impedance detection module, the colorimetric detection module, the turbidimetric detection module, and the luminescence detection module may be implemented in the form of a plug-in.

In practical applications, the sample testing device 1 may be implemented by the following examples:

a user inputs items to be detected, such as colorimetric detection, impedance detection and turbidimetric detection, through the display module 90, the control module 80 sends a start signal to the first driving member A1 according to the input items, at this time, the first driving member A1 drives the first slider 62 to drive the card hopper 10 to slide to the first detection area E1 on the horizontal guide rail member 61; the control module 80 sends a start signal to the second driving member B1, and the second driving member B1 drives the second slider 72 to slide on the vertical guide member 71, so as to push the piston 111 to slide to a first predetermined area of the detection card 11; the control module 80 then sends a detection signal to the colorimetric detection module, which begins detecting. After the detection is finished, the first driving member A1 drives the first slider 62 to drive the card hopper 10 to slide to the second detection area E2 on the horizontal guide rail member 61, and the second driving member B1 drives the second slider 72 to slide on the vertical guide rail member 71 to push the piston 111 to slide to a second predetermined area of the detection card 11; the control module 80 then sends a detection signal to the impedance detection module, which begins detection. After the detection is finished, the first driving member A1 drives the first slider 62 to drive the card hopper 10 to slide to the third detection area E3 on the horizontal guide rail member 61, and the second driving member B1 drives the second slider 72 to slide on the vertical guide rail member 71 to push the piston 111 to slide to the third predetermined area of the detection card 11; next, the control module 80 sends a detection signal to the turbidimetric detection module, the turbidimetric detection module starts detection, and after detection is completed, the print module 100 prints a detection result.

< method of detecting sample >

As shown in fig. 12, a second aspect of the present embodiment provides a sample detection method, which is applied to the sample detection apparatus provided in the first aspect of the present embodiment, and the sample detection method includes:

s101, the colorimetric detection module receives the first detection signal and executes colorimetric detection.

S102, the impedance detection module receives the second detection signal and executes impedance detection.

And S103, receiving the third detection signal by the turbidimetric detection module, and executing turbidimetric detection.

And S104, receiving the fourth detection signal by the light-emitting detection module, and executing light-emitting detection.

In a specific embodiment, the sample detection method can be implemented by the following action processes:

firstly, a detection card 11 filled with a sample and a reagent is placed in a card chamber 10;

secondly, the display module 90 sends the received detection instruction sequence to the control module 80, and the control module 80 temporarily stores the instruction sequence for later use;

thirdly, the control module 80 instructs the driving module 110 to drive the horizontal guide rail assembly 60 to operate according to a predetermined instruction, the card bin 10 is driven by the first sliding block 62 to horizontally operate, and when the piston 111 is aligned with the push rod 721, the first sliding block 62 stops operating;

fourthly, the control module 80 instructs the driving module 110 to drive the vertical guide assembly 70 to operate according to a predetermined instruction, and the second slider 72 drives the push rod 721 to move downward, so as to push the piston 111 to slide to a first predetermined area of the detection card 11, so that the mixed solution of the sample and the reagent enters a colorimetric detection area of the detection card 11;

fifthly, the control module 80 instructs the driving module 110 to drive the vertical guide assembly 70 to operate according to a predetermined instruction, and the second slider 72 drives the push rod 721 to move upwards to the initial position;

sixthly, the control module 80 instructs the driving module 110 to drive the horizontal guide rail assembly 60 to operate according to a predetermined instruction, and the card chamber 10 is driven by the first sliding block 62 to operate horizontally to the first detection port;

seventh, the control module 80 instructs the colorimetric detection device 20 to start colorimetric detection according to a predetermined instruction;

eighth, after the colorimetric detection is completed, the control module 80 instructs the driving module 110 to drive the horizontal guide rail assembly 60 to operate according to a predetermined instruction, the card bin 10 is driven by the first sliding block 62 to operate horizontally, when the piston 111 is aligned with the push rod 721, the first sliding block 62 stops operating, and at this time, the detection card 11 is located at the second detection port;

ninthly, the control module 80 instructs the driving module 110 to drive the vertical guide assembly 70 to operate according to a predetermined instruction, and the second slider 72 drives the push rod 721 to move downward, so as to push the piston 111 to slide to a second predetermined area of the detection card 11, so that the mixed liquid enters an impedance detection area of the detection card 11;

tenth, the control module 80 instructs the impedance detection device 30 to start impedance detection according to a predetermined instruction, and while performing the impedance detection, the control module 80 instructs the driving module 110 to drive the vertical guide rail assembly 70 to operate according to the predetermined instruction, so that the second slider 72 drives the push rod 721 to move downward, and the piston 111 is pushed to flow the mixed solution;

eleventh, after the impedance detection is completed, the control module 80 instructs the driving module 110 to drive the vertical guide assembly 70 to operate according to a predetermined instruction, and the second slider 72 drives the push rod 721 to move downward, so as to push the piston 111 to slide to a third predetermined area of the detection card 11, so that the mixed liquid enters a turbidimetric detection area of the detection card 11;

twelfth, the control module 80 instructs the driving module 110 to drive the vertical guide assembly 70 to operate according to a predetermined command, and the second sliding block 72 drives the push rod 721 to move upward to the initial position;

thirteenth, the control module 80 instructs the driving module 110 to drive the horizontal guide rail assembly 60 to operate according to a predetermined instruction, and the card bin 10 is driven by the first sliding block 62 to horizontally operate until reaching the third detection port;

fourteenth, if necessary, the control module 80 instructs the driving module 110 to drive the blending component 120 according to a predetermined instruction, so as to blend the mixed liquid;

fifteenth, if necessary, the control module 80 instructs the driving module 110 to drive the incubation member 140 according to a predetermined command, and incubate the mixture;

sixthly, the control module 80 instructs the turbidimetry detection device 40 to start turbidimetry detection according to a predetermined instruction;

seventeenth, after turbidity detection is completed, the control module 80 instructs the driving module 110 to drive the horizontal guide rail assembly 60 to operate according to a predetermined instruction, the cartridge 10 is driven by the first sliding block 62 to operate horizontally, and when the piston 111 is aligned with the push rod 721, the first sliding block 62 stops operating;

eighteenth, the control module 80 instructs the driving module 110 to drive the vertical guide assembly 70 to operate according to a predetermined instruction, and the second slider 72 drives the push rod 721 to move downward, so as to push the piston 111 to slide to a fourth predetermined area of the detection card 11, so that the mixed liquid enters a light-emitting detection area of the detection card 11;

nineteenth, the control module 80 instructs the driving module 110 to drive the vertical rail assembly 70 to operate according to a predetermined instruction, and the second sliding block 72 drives the push rod 721 to move upwards to the initial position;

twentieth, the control module 80 instructs the driving module 110 to drive the horizontal guide rail assembly 60 to operate according to a predetermined instruction, and the card chamber 10 is driven by the first sliding block 62 to horizontally operate to the fourth detection port;

twenty-first, if necessary, the control module 80 instructs the driving module 110 to drive the light shielding member 130 according to a predetermined instruction, so as to shield the ambient light interference;

twenty-two, if necessary, the control module 80 instructs the driving module 110 to drive the incubation member 140 to incubate the mixture according to the predetermined instruction;

twenty-third, the control module 80 instructs the light-emission detecting device 50 to start light-emission detection according to a predetermined instruction;

twenty-fourth, after the detection of the plurality of items is completed, the control module 80 instructs the driving module 110 to drive the horizontal guide rail assembly 60 to operate according to a predetermined instruction, and the card bin 10 is driven by the first sliding block 62 to horizontally operate, and then the card bin is taken out of the machine.

The embodiments and embodiments of the present application have been described above, and the description is not limited thereto, and what is shown in the drawings is only one of the embodiments of the present application, and the actual configuration is not limited thereto. In summary, those skilled in the art should, without departing from the spirit of the embodiments of the present application, devise similar structural modes and embodiments without inventing and designing the same, shall fall within the scope of the embodiments of the present application.

Claims (10)

1. A sample testing device, comprising:

the card bin is used for accommodating a detection card containing a sample and a reagent;

the colorimetric detection device comprises a colorimetric detection module and a first detection area, wherein the colorimetric detection module is used for detecting a detection card in the first detection area;

the impedance detection device comprises an impedance detection module and a second detection area, wherein the impedance detection module is used for detecting a detection card in the second detection area;

the turbidimetric detection device comprises a turbidimetric detection module and a third detection area, wherein the turbidimetric detection module is used for detecting a detection card in the third detection area;

the light-emitting detection device comprises a light-emitting detection module and a fourth detection area, wherein the light-emitting detection module is used for detecting a detection card in the fourth detection area;

the card bin is connected with the horizontal guide rail assembly in a sliding mode, and slides to the first detection area, the second detection area, the third detection area and the fourth detection area on the horizontal guide rail assembly according to a time sequence;

the vertical guide rail assembly pushes a piston of the detection card to slide according to time sequence;

when the card bin slides to the first detection area, the vertical guide rail assembly pushes the piston to slide to a first preset area of the detection card, so that a mixed solution of a sample and a reagent enters a colorimetric detection area of the detection card, and the colorimetric detection module performs colorimetric detection on the mixed solution;

when the card bin slides to the second detection area, the vertical guide rail assembly pushes the piston to slide to a second preset area of the detection card, so that the mixed liquid enters an impedance detection area of the detection card, and the impedance detection module performs impedance detection on the mixed liquid;

when the card bin slides to the third detection area, the vertical guide rail assembly pushes the piston to slide to a third preset area of the detection card, so that the mixed liquid enters a turbidimetric detection area of the detection card, and the turbidimetric detection module performs turbidimetric detection on the mixed liquid;

when the card bin slides to the fourth detection area, the vertical guide rail assembly pushes the piston to slide to the fourth preset area of the detection card, so that the mixed liquid enters the light-emitting detection area of the detection card, and the light-emitting detection module performs light-emitting detection on the mixed liquid.

2. The sample detection device of claim 1, further comprising a control module configured to send detection signals to the impedance detection module, the colorimetric detection module, the turbidimetric detection module, and the luminescence detection module.

3. The sample testing device of claim 2, further comprising a display module electrically connected to said control module and a printing module electrically connected to said control module, said display module configured to enable interaction of said sample testing device with a user, and said printing module configured to print a test result.

4. The sample testing device of claim 3, wherein said horizontal rail assembly comprises a horizontal rail member and a first slider, said first slider being slidably coupled to said horizontal rail member, said cartridge being disposed on said first slider.

5. The sample testing device of claim 4, wherein said vertical guide assembly comprises a vertical guide member and a second slide, said second slide being slidably connected to said vertical guide member, said second slide being provided with a push rod for pushing said plunger.

6. The sample testing device of claim 5, further comprising a drive module, wherein each of said first slider and said second slider is coupled to said drive module;

the driving module is electrically connected with the control module, and the control module is further used for sending a control signal to the driving module.

7. The sample testing device of claim 6, further comprising a blending member electrically connected to the drive module.

8. The sample detection device of claim 7, wherein the first detection region is located at a first detection port of the colorimetric detection module; the second detection area is positioned at a second detection port of the impedance detection module; the third detection area is positioned at a third detection port of the turbidimetric detection module; the fourth detection area is located at a fourth detection port of the luminescence detection module.

9. The sample detection device of claim 8, further comprising a light blocking member and an incubation member, both of which are electrically connected to the drive module.

10. A sample detection method applied to the sample detection apparatus according to any one of claims 1 to 9, comprising:

the colorimetric detection module receives the first detection signal and executes colorimetric detection;

the impedance detection module receives the second detection signal and executes impedance detection;

the turbidimetric detection module receives the third detection signal and executes turbidimetric detection;

and the light-emitting detection module receives the fourth detection signal and executes light-emitting detection.

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