CN115500353B - Fluazinam and benziothiazolinone granules and preparation method thereof - Google Patents
Fluazinam and benziothiazolinone granules and preparation method thereof Download PDFInfo
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- CN115500353B CN115500353B CN202211355929.7A CN202211355929A CN115500353B CN 115500353 B CN115500353 B CN 115500353B CN 202211355929 A CN202211355929 A CN 202211355929A CN 115500353 B CN115500353 B CN 115500353B
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- coating agent
- fluazinam
- benziothiazolinone
- film coating
- water
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- 239000008187 granular material Substances 0.000 title claims abstract description 139
- 239000005780 Fluazinam Substances 0.000 title claims abstract description 138
- UZCGKGPEKUCDTF-UHFFFAOYSA-N fluazinam Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=C(Cl)C([N+]([O-])=O)=C1NC1=NC=C(C(F)(F)F)C=C1Cl UZCGKGPEKUCDTF-UHFFFAOYSA-N 0.000 title claims abstract description 138
- 238000002360 preparation method Methods 0.000 title abstract description 36
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 143
- 239000007888 film coating Substances 0.000 claims abstract description 98
- 238000009501 film coating Methods 0.000 claims abstract description 98
- 238000002156 mixing Methods 0.000 claims abstract description 31
- 239000002897 polymer film coating Substances 0.000 claims abstract description 28
- 239000011259 mixed solution Substances 0.000 claims abstract description 26
- 239000000843 powder Substances 0.000 claims abstract description 22
- 238000004898 kneading Methods 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 17
- 238000001035 drying Methods 0.000 claims abstract description 16
- 238000010902 jet-milling Methods 0.000 claims abstract description 16
- 238000012216 screening Methods 0.000 claims abstract description 16
- 238000001179 sorption measurement Methods 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000839 emulsion Substances 0.000 claims description 26
- 239000004021 humic acid Substances 0.000 claims description 16
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 15
- 239000011118 polyvinyl acetate Substances 0.000 claims description 15
- 239000002202 Polyethylene glycol Substances 0.000 claims description 14
- 229920001223 polyethylene glycol Polymers 0.000 claims description 14
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 claims description 10
- 241000233622 Phytophthora infestans Species 0.000 claims description 10
- -1 nitro humic acid Chemical compound 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 7
- 239000003337 fertilizer Substances 0.000 claims description 7
- 241000233647 Phytophthora nicotianae var. parasitica Species 0.000 claims description 6
- 206010039509 Scab Diseases 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims description 4
- HDERJYVLTPVNRI-UHFFFAOYSA-N ethene;ethenyl acetate Chemical group C=C.CC(=O)OC=C HDERJYVLTPVNRI-UHFFFAOYSA-N 0.000 claims description 4
- 229920001038 ethylene copolymer Polymers 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 244000215068 Acacia senegal Species 0.000 claims description 3
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 3
- 229920000084 Gum arabic Polymers 0.000 claims description 3
- 239000000205 acacia gum Substances 0.000 claims description 3
- 235000010489 acacia gum Nutrition 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 150000003863 ammonium salts Chemical class 0.000 claims description 2
- 159000000007 calcium salts Chemical class 0.000 claims description 2
- 239000002270 dispersing agent Substances 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 150000002696 manganese Chemical class 0.000 claims description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- 150000003751 zinc Chemical class 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002689 soil Substances 0.000 abstract description 44
- 230000000694 effects Effects 0.000 abstract description 22
- 238000000034 method Methods 0.000 abstract description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 12
- 201000010099 disease Diseases 0.000 abstract description 11
- 239000000575 pesticide Substances 0.000 abstract description 10
- 238000013270 controlled release Methods 0.000 abstract description 4
- 230000000052 comparative effect Effects 0.000 description 15
- 244000061456 Solanum tuberosum Species 0.000 description 13
- 235000002595 Solanum tuberosum Nutrition 0.000 description 13
- 239000000203 mixture Substances 0.000 description 12
- 239000004594 Masterbatch (MB) Substances 0.000 description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 11
- 239000004480 active ingredient Substances 0.000 description 8
- 239000000987 azo dye Substances 0.000 description 8
- 230000015556 catabolic process Effects 0.000 description 8
- 238000006731 degradation reaction Methods 0.000 description 8
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 8
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 8
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 235000012015 potatoes Nutrition 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 210000004602 germ cell Anatomy 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 238000003912 environmental pollution Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 238000002386 leaching Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- LWEAHXKXKDCSIE-UHFFFAOYSA-M 2,3-di(propan-2-yl)naphthalene-1-sulfonate Chemical compound C1=CC=C2C(S([O-])(=O)=O)=C(C(C)C)C(C(C)C)=CC2=C1 LWEAHXKXKDCSIE-UHFFFAOYSA-M 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000005416 organic matter Substances 0.000 description 2
- 239000002985 plastic film Substances 0.000 description 2
- 229920006255 plastic film Polymers 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical class NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000005602 Coleus parviflorus Nutrition 0.000 description 1
- 244000096857 Dioscorea batatas Species 0.000 description 1
- 235000002722 Dioscorea batatas Nutrition 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 241000233614 Phytophthora Species 0.000 description 1
- 241000221662 Sclerotinia Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- DCYOBGZUOMKFPA-UHFFFAOYSA-N iron(2+);iron(3+);octadecacyanide Chemical compound [Fe+2].[Fe+2].[Fe+2].[Fe+3].[Fe+3].[Fe+3].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] DCYOBGZUOMKFPA-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- LZGUHMNOBNWABZ-UHFFFAOYSA-N n-nitro-n-phenylnitramide Chemical compound [O-][N+](=O)N([N+]([O-])=O)C1=CC=CC=C1 LZGUHMNOBNWABZ-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000005381 potential energy Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229960003351 prussian blue Drugs 0.000 description 1
- 239000013225 prussian blue Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000035806 respiratory chain Effects 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses fluazinam and benziothiazolinone granules and a preparation method thereof. The granule comprises fluazinam, benziothiazolinone, a polymer film coating agent and auxiliary materials. The preparation method of the invention comprises the following steps: (1) Mixing fluazinam, benziothiazolinone and auxiliary materials, and performing jet milling to form granule mother powder; (2) Uniformly mixing a water-soluble film coating agent and a non-water-soluble film coating agent to form a film coating agent mixed solution; (3) And adding the prepared film coating agent mixed solution into the granule master powder for adsorption and kneading, granulating, drying and screening to obtain fluazinam and benziothiazolinone granules. The invention has the advantages of easily obtained granule materials and simple process, and particularly creatively uses the polymer film coating agent to replace water for kneading and granulating, so that the prepared product has obvious controlled release effect on the basis of not improving the complexity of the granulating process, achieves the purpose of long-acting disease control, and particularly effectively relieves the problem that the benziothiazolinone and fluazinam are easy to degrade and lose efficacy in soil on the basis of not influencing the control effect, has fewer times and less dosage, improves the pesticide utilization rate, simultaneously is safe to crops, saves the cost and reduces the pollution to the environment.
Description
Technical Field
The invention relates to the technical field of pesticides, in particular to fluazinam and benziothiazolinone granules and a preparation method thereof.
Background
In the 21 st century, the planting area of Chinese potatoes is the second place in the world, but the potatoes in China are affected by diseases such as late blight, black shank, scab and the like all the year round, and the prevention and treatment of the diseases such as the late blight, the black shank, the scab and the like of the potatoes by fluazinam and benziothiazolinone are conventional choices, and the effect is excellent.
Fluazinam (fluazinam) is an organic compound belonging to the class of pyridine amine derivatives, dinitroaniline bactericides. Has no therapeutic effect and systemic activity, and is a broad-spectrum efficient protective bactericide. Is very effective against alternaria, phytophthora, uniaxial mould, sclerotinia and black fungus. Fluazinam acts on a plurality of specific sites of ATP synthase to release the association of oxidation and phosphorylation at the tail end of respiratory chain, so as to consume the electrochemical potential energy accumulated by electron transfer to the maximum extent and block the formation of germ energy (ATP), thereby leading germ to die. The fluazinam is stable under acidic conditions, is easy to hydrolyze under neutral and alkaline conditions, and is more favorable for degrading the fluazinam in soil under alkaline and higher organic matter content.
Benziothiazolinone is a novel broad-spectrum bactericide and is mainly used for preventing and treating various bacterial and fungal diseases of cruciferous crops, vegetables, fruits and the like. The sterilization mechanism mainly comprises two aspects of destroying the nuclear structure of germ cells, leading the germ cells to lose heart parts and failure death and interfering metabolism of germ cells, leading the germ cells to be physiological disorder and finally leading the germ cells to death. The plant can be effectively protected from being infected by the pathogen when the plant is used in the early stage of disease occurrence, and the spreading of germs can be obviously controlled by increasing the dosage after the disease occurrence, so that the double functions of protection and eradication are achieved. The solubility in water (20 ℃) was 4g/L.
The main potato producing areas in China are in Gansu, inner Mongolia and northeast three provinces, most of the places are northern, the rainfall is small, acidic substances in soil are small, the soil is alkaline, the soil is fat, the organic matter content is high, the stability of soil treatment agent pesticides for preventing and treating potato diseases such as fluazinam is influenced, the degradation in the soil is easy, the lasting time is short, and multiple application is needed.
At present, the common preparation used for preventing and treating potato related diseases is granules, because the granules are produced by mixing active ingredients with auxiliary materials, carrying out jet milling, adding a proper amount of water, carrying out kneading granulation by a granule kneader, drying and screening; in application, the granular product has the advantages of good sedimentation, small drift, light environmental pollution, convenient application, labor and time saving, and can be released as a concentrated area of the soil treatment agent, but the pesticide active ingredient fluazinam and the like are easily lost or degraded due to the rain wash leaching effect and/or the soil pH influence and the microorganism effect, the duration is shorter, and further the application times and the application amount are required to be increased, so that the application cost is increased and the environmental pollution is caused. Therefore, there is an urgent need to develop a stable and long-acting granule preparation method with controlled release to change the condition.
Furthermore, the information disclosed in this background section is only for the purpose of increasing the understanding of the general background of the invention and should not be taken as an acknowledgment or any form of suggestion that this information forms the prior art already known to those of ordinary skill in the art.
Disclosure of Invention
The invention aims to solve the problems that the fluazinam and the benziothiazolinone containing granules prepared in the prior art are easy to cause loss or degradation of the effective components of pesticides due to the rain wash leaching effect and/or the soil pH influence and the microbial effect, and further the application times and the application dosage are required to be increased, so that the application cost is increased and the environment is polluted.
The granule containing fluazinam and benziothiazolinone comprises fluazinam, benziothiazolinone, a polymer film coating agent and auxiliary materials, wherein the polymer film coating agent comprises 4-20% of water-soluble film coating agent and 80-96% of water-insoluble film coating agent.
The invention also provides a fluazinam and benziothiazolinone granule and a preparation method thereof, comprising the following steps of
(1) Mixing fluazinam, benziothiazolinone and auxiliary materials, and performing jet milling to form granule mother powder;
(2) Uniformly mixing a water-soluble film coating agent and a non-water-soluble film coating agent to form a film coating agent mixed solution;
(3) And adding the prepared film coating agent mixed solution into the granule master powder for adsorption and kneading, granulating, drying and screening to obtain fluazinam and benziothiazolinone granules.
The invention also discloses application of the fluazinam and benziothiazolinone-containing granules in preventing and treating potato late blight, black shank and scab.
The beneficial effects of the invention are that
The high molecular water-soluble and water-insoluble film coating agent is adsorbed on the surface of the master powder of the fluazinam and benziothiazolinone-containing granules to form a layer-by-layer film coating. Wherein, a small amount of water-soluble film coating agent in the coating film can be dissolved in the water in the soil, and the agent is released to achieve the prevention effect; wherein, a large amount of water-insoluble film coating agents in the coating film can prevent most surfaces of the granules from contacting with water in soil to form a water-impermeable film, and prevent a large amount of agents from being released into the soil rapidly. Therefore, the granule provided by the invention can obviously control the release effect after being applied to soil, prolong the duration of the medicament, reduce the application times and frequency, and simultaneously can well control the occurrence of diseases in the whole growth period of potatoes.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention. Throughout the specification and claims, unless explicitly stated otherwise, the term "comprise" or variations thereof such as "comprises" or "comprising", etc. will be understood to include the stated component or section without excluding other components or sections. In addition, numerous specific details are set forth in the following description in order to provide a better illustration of the invention.
The invention provides a fluazinam and benziothiazolinone-containing granule, which comprises fluazinam, benziothiazolinone, a high polymer film coating agent and auxiliary materials, wherein the high polymer film coating agent comprises 4-20% of a water-soluble film coating agent and 80-96% of a water-insoluble film coating agent. The granule with excellent performance can be obtained by selecting proper dosage of the water-soluble film coating agent and the water-insoluble film coating agent. The water-soluble film coating agent can achieve the effect of releasing pesticides, and the water-insoluble film coating agent can prevent the influence of soil environment on the pesticides, so that the release time and degradation speed of the pesticides can be prolonged.
In some embodiments, the fluazinam and the benziothiazolinone granules have a weight percentage of 5-40% and the benziothiazolinone has a weight percentage of 1-10%; preferably, the fluazinam is 15-37.5% by weight and the benziothiazolinone is 2-5% by weight.
Further, in some embodiments, the weight ratio of the fluazinam to the benziothiazolinone and the fluazinam in the granule is 1: (1-10); preferably, the weight ratio of the benziothiazolinone to the fluazinam is 1: (5-10). The combination of the two pesticide components in the above ratio range has better synergistic effect.
In some embodiments, the weight percentage of the polymer film coating agent contained in the fluazinam and benziothiazolinone granules is 10-20%; preferably, the weight percentage of the polymer film coating agent is 12-16%. The polymer film coating agent comprises 4-20% of water-soluble film coating agent and 80-96% of water-insoluble film coating agent, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1: (4-24); optionally, the polymer film coating agent comprises 8-12% of water-soluble film coating agent and 88-92% of water-insoluble film coating agent, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1: (7.3-11.5). The water-soluble film coating agent is selected from one or two of polyethylene glycol, gelatin, gum arabic, sodium carboxymethyl cellulose and polyvinylpyrrolidone; the water-insoluble film coating agent is one or two of cellulose acetate phthalate emulsion, polyvinyl acetate emulsion, vinyl acetate-ethylene copolymer emulsion and acrylic acid copolymer emulsion. The applicant has found that, in particular, the use of a combination of a water-soluble film-forming agent and a water-insoluble film-forming agent, both of which are preferably used, provides more excellent effects such as sustained release performance, release duration, etc. of the granules produced in a certain ratio range.
Furthermore, the fluazinam and benziothiazolinone granules contain auxiliary materials, wherein the auxiliary materials comprise humic acid fertilizer, dispersing agent, wetting agent, solid carrier and warning color. Wherein the auxiliary material contains humic acid fertilizer, wherein the humic acid fertilizer comprises humic acid, nitro humic acid, humic acid water-soluble salt and nitro humic acid water-soluble salt, and the water-soluble salt comprises sodium salt, potassium salt, calcium salt, zinc salt, manganese salt and ammonium salt. The humic acid fertilizer can promote the growth of plants and improve the yield of the plants.
The invention also provides a preparation method of the fluazinam and benziothiazolinone granule, which comprises the following steps:
(1) Mixing fluazinam, benziothiazolinone and auxiliary materials, and performing jet milling to form granule mother powder;
(2) Uniformly mixing a water-soluble film coating agent and a non-water-soluble film coating agent to form a film coating agent mixed solution;
(3) And adding the prepared film coating agent mixed solution into the granule master powder for adsorption and kneading, granulating, drying and screening to obtain the fluazinam and benziothiazolinone granule.
The preparation method is simple, easy for industrial production and stable in product quality.
The invention also discloses application of the fluazinam and benziothiazolinone granules in preventing and treating potato late blight, black shank and scab. The fluazinam and benziothiazolinone granule prepared by the invention has good effect in application in preventing and treating potato late blight, black shank and scab, has long lasting period, and can play a good role in preventing and treating potato in the whole growth period.
It will be appreciated by those skilled in the art that in some embodiments, materials, methods, means, etc. well known to those skilled in the art have not been described in detail in order to facilitate the salient features of the present invention. The raw materials in the following examples are all commercially available.
1. Preparation examples
Example 1
A preparation method of fluazinam and benziothiazolinone granules, which comprises the following steps:
(1) Mixing 3g of benziothiazolinone, 22.5g of fluazinam with 10g of ammonium humate, 3g of sodium lignin sulfonate, 3g of sodium dodecyl benzene sulfonate, 30g of kieselguhr and 0.5g of azo dye, and performing jet milling to form granule mother powder;
(2) Uniformly mixing 1.4g of polyethylene glycol and 12.6g of polyvinyl acetate emulsion to form a film coating agent mixed solution;
(3) And (3) dripping the film coating agent mixture obtained in the step (2) into the granule master batch obtained in the step (1), carrying out adsorption kneading, granulating, drying and screening to obtain fluazinam benziothiazolinone granules.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 14%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:9.
example 2
A preparation method of fluazinam and benziothiazolinone granules, which comprises the following steps:
(1) Mixing 3g of benziothiazolinone, 22.5g of fluazinam with 10g of ammonium humate, 3g of sodium lignin sulfonate, 3g of sodium dodecyl benzene sulfonate, 30g of kieselguhr and 0.5g of azo dye, and performing jet milling to form granule mother powder;
(2) Uniformly mixing 1.69g of polyethylene glycol and 12.31g of polyvinyl acetate emulsion to form a film coating agent mixed solution;
(3) And (3) dripping the film coating agent mixture obtained in the step (2) into the granule master batch obtained in the step (1), carrying out adsorption kneading, granulating, drying and screening to obtain fluazinam benziothiazolinone granules.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 14%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:7.3.
example 3
A preparation method of fluazinam and benziothiazolinone granules, which comprises the following steps:
(1) Mixing 3g of benziothiazolinone, 22.5g of fluazinam with 10g of nitro humic acid, 3g of sodium lignin sulfonate, 3g of sodium dodecyl benzene sulfonate, 30g of kieselguhr and 0.5g of azo dye, and performing jet milling to form granule mother powder;
(2) Uniformly mixing 1.45g of polyethylene glycol and 10.55g of polyvinyl acetate emulsion to form a film coating agent mixed solution;
(3) And (3) dripping the film coating agent mixture obtained in the step (2) into the granule master batch obtained in the step (1), carrying out adsorption kneading, granulating, drying and screening to obtain fluazinam benziothiazolinone granules.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 12 percent, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:7.3.
example 4
A preparation method of fluazinam and benziothiazolinone granules, which comprises the following steps:
(1) Mixing 2g of benziothiazolinone, 15g of fluazinam with 10g of nitro humic acid, 3g of methylene dinaphthyl sodium sulfonate, 3g of sodium dodecyl benzene sulfonate, 30g of kieselguhr and 0.5g of azo dye, and performing jet milling to form granule mother powder;
(2) Uniformly mixing 1.12g of polyvinylpyrrolidone and 12.88g of cellulose acetate phthalate emulsion to form a coating agent mixed solution;
(3) And (3) dripping the film coating agent mixture obtained in the step (2) into the granule master batch obtained in the step (1), carrying out adsorption kneading, granulating, drying and screening to obtain fluazinam benziothiazolinone granules.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 14%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:11.5.
example 5
A preparation method of fluazinam and benziothiazolinone granules, which comprises the following steps:
(1) Mixing 2g of benziothiazolinone, 15g of fluazinam with 10g of sodium humate, 3g of polycarboxylate, 3g of alkyl naphthalene formaldehyde condensate sulfonate, 30g of kaolin and 0.5g of azo dye, and performing jet milling to form granule mother powder;
(2) Uniformly mixing 1.28g of polyvinylpyrrolidone and 14.72g of polyvinyl acetate emulsion to form a film coating agent mixed solution;
(3) And (3) dripping the film coating agent mixture obtained in the step (2) into the granule master batch obtained in the step (1), carrying out adsorption kneading, granulating, drying and screening to obtain fluazinam benziothiazolinone granules.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 16%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:11.5.
example 6
A preparation method of fluazinam and benziothiazolinone granules, which comprises the following steps:
(1) Mixing 5g of benziothiazolinone, 37.5g of fluazinam with 10g of sodium humate, 3g of sodium lignin sulfonate, 3g of sodium dodecyl benzene sulfonate, 30g of white carbon black and 0.5g of Prussian blue, and performing jet milling to form granule mother powder;
(2) Uniformly mixing 2g of gum arabic and 8g of polyvinyl acetate emulsion to form a film coating agent mixed solution;
(3) And (3) dripping the film coating agent mixture obtained in the step (2) into the granule master batch obtained in the step (1), carrying out adsorption kneading, granulating, drying and screening to obtain fluazinam benziothiazolinone granules.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 10%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:4.
example 7
A preparation method of fluazinam and benziothiazolinone granules, which comprises the following steps:
(1) Mixing 5g of benziothiazolinone, 37.5g of fluazinam with 10g of potassium humate, 3g of calcium lignosulfonate, 3g of sodium dodecyl benzene sulfonate, 30g of kieselguhr and 0.5g of metal phthalocyanine, and performing jet milling to form granule mother powder;
(2) Uniformly mixing 4g of sodium carboxymethyl cellulose, 16g of vinyl acetate-ethylene copolymer emulsion and acrylic acid copolymer emulsion to form a film coating agent mixed solution;
(3) And (3) dripping the film coating agent mixture obtained in the step (2) into the granule master batch obtained in the step (1), carrying out adsorption kneading, granulating, drying and screening to obtain fluazinam benziothiazolinone granules.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 20%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:4.
example 8
A preparation method of fluazinam and benziothiazolinone granules, which comprises the following steps:
(1) Mixing 1g of benziothiazolinone, 7.5g of fluazinam with 10g of potassium humate, 3g of sodium lignin sulfonate, 3g of nekal, 30g of bentonite and 0.5g of triphenylmethane dye, and performing jet milling to form granule mother powder;
(2) Uniformly mixing 0.4g of polyethylene glycol and 9.6g of polyvinyl acetate emulsion to form a film coating agent mixed solution;
(3) And (3) dripping the film coating agent mixture obtained in the step (2) into the granule master batch obtained in the step (1), carrying out adsorption kneading, granulating, drying and screening to obtain fluazinam benziothiazolinone granules.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 10%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:24.
example 9
A preparation method of fluazinam and benziothiazolinone granules, which comprises the following steps:
(1) Mixing 1g of benziothiazolinone, 7.5g of fluazinam with 10g of calcium humate, 3g of sodium lignin sulfonate, 3g of nekal, 30g of talcum powder and 0.5g of azo dye, and performing jet milling to form granule mother powder;
(2) Uniformly mixing 0.8g of polyethylene glycol, 19.2g of vinyl acetate-ethylene copolymer emulsion and acrylic acid copolymer emulsion to form a laminating agent mixed solution;
(3) And (3) dripping the film coating agent mixture obtained in the step (2) into the granule master batch obtained in the step (1), carrying out adsorption kneading, granulating, drying and screening to obtain fluazinam benziothiazolinone granules.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 20%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:24.
example 10
A preparation method of fluazinam and benziothiazolinone granules, which comprises the following steps:
(1) Mixing 1g of benziothiazolinone, 5g of fluazinam with 10g of magnesium humate, 3g of sodium lignin sulfonate, 3g of sodium dodecyl benzene sulfonate, 30g of kieselguhr and 0.5g of azo dye, and performing jet milling to form granule mother powder;
(2) Uniformly mixing 2g of polyethylene glycol and 8g of polyvinyl acetate emulsion to form a film coating agent mixed solution;
(3) And (3) dripping the film coating agent mixture obtained in the step (2) into the granule master batch obtained in the step (1), carrying out adsorption kneading, granulating, drying and screening to obtain fluazinam benziothiazolinone granules.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:5, a step of; the weight percentage of the prepared polymer film coating agent is 10%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:4.
example 11
A preparation method of fluazinam and benziothiazolinone granules, which comprises the following steps:
(1) Mixing 4g of benziothiazolinone, 40g of fluazinam with 10g of zinc humate, 3g of sodium lignin sulfonate, 3g of sodium dodecyl benzene sulfonate, 30g of kieselguhr and 0.5g of azo dye, and performing jet milling to form granule mother powder;
(2) Uniformly mixing 4g of polyethylene glycol and 16g of polyvinyl acetate emulsion to form a film coating agent mixed solution;
(3) And (3) dripping the film coating agent mixture obtained in the step (2) into the granule master batch obtained in the step (1), carrying out adsorption kneading, granulating, drying and screening to obtain fluazinam benziothiazolinone granules.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:10; the weight percentage of the prepared polymer film coating agent is 20%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:24.
comparative example 1
A preparation method of fluazinam and benziothiazolinone granules, which is similar to example 1 in that:
the coating agent mixture obtained in the step (2) is replaced by equal amount of water.
Comparative example 2
A preparation method of fluazinam and benziothiazolinone granules, which is similar to example 1 in that:
the coating agent mixed solution in the step (2) is replaced by the same amount of polyethylene glycol.
Comparative example 3
A preparation method of fluazinam and benziothiazolinone granules, which is similar to example 1 in that:
the coating agent mixed solution in the step (2) is replaced by an equivalent amount of polyvinyl acetate emulsion.
Comparative example 4
A preparation method of fluazinam and benziothiazolinone granules, which is similar to example 1 in that:
in the step (2), 3.5g of polyethylene glycol and 10.5g of polyvinyl acetate emulsion are selected and uniformly mixed to form a film coating agent mixed solution.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 14%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:3.
comparative example 5
A preparation method of fluazinam and benziothiazolinone granules, which is similar to example 1 in that:
in the step (2), 0.54g of polyethylene glycol and 13.46g of polyvinyl acetate emulsion are selected and uniformly mixed to form a film coating agent mixed solution.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 14%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:25.
comparative example 6
A preparation method of fluazinam and benziothiazolinone granules, which is similar to example 1 in that:
the diatomite in the step (1) is used for 30g;
in the step (2), 2.1g of polyethylene glycol and 18.9g of polyvinyl acetate emulsion are selected and uniformly mixed to form a film coating agent mixed solution.
The method can not prepare fluazinam and benziothiazolinone granules because the materials are in gel paste form after the film covering agent mixed solution is added, and can not be granulated, and the weight ratio of the benziothiazolinone to the benziothiazolinone in the method is 1:7.5; the weight percentage of the prepared polymer film coating agent is 21%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:9.
comparative example 7
A preparation method of fluazinam and benziothiazolinone granules, which is similar to example 1 in that:
the diatomite in the step (1) is used for 30g;
in the step (2), 0.9g of polyethylene glycol and 8.1g of polyvinyl acetate emulsion are selected and uniformly mixed to form a film coating agent mixed solution.
In the fluazinam and benziothiazolinone granules prepared by the method, the weight ratio of the benziothiazolinone to the fluazinam is 1:7.5; the weight percentage of the prepared polymer film coating agent is 9%, wherein the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1:9.
2. application examples
Test example 1
Indoor determination of release rate of fluazinam and benziothiazolinone granules in soil
Test preparation: taking soil of a northeast potato planting area in China, wherein no other pesticide components are applied to the soil for nearly 2 years, taking cultivated soil with the depth of 10cm from the surface of the soil, crushing uniformly, sieving with a 40-mesh sieve, adjusting the humidity to 75-85%, and putting the ground soil into a flowerpot (with the diameter of 20 cm) with a bottom without holes, wherein the thickness of 15cm for later use; placing the sieved soil in a high-temperature box at 600 ℃ for baking for 8 hours to enable organic substances in the soil to be fully burnt into inorganic substances, taking out, cooling, adjusting the humidity to 75-85%, and placing the soil into a flowerpot (diameter is 20 cm) with a bottom without holes, wherein the thickness is 15cm for standby;
2g of each flowerpot is placed into a treatment agent, the fluazinam and benziothiazolinone granules of examples 1, 3, 5, 7, 9 and 11 and comparative examples 1-5 and comparative example 7 are placed into a mesh cloth bag with holes of 200 meshes, the agent can be paved in the mesh cloth bag, a binding opening is placed into the flowerpot, 10cm of soil which is not subjected to high-temperature baking treatment is covered, 500mL of water is dripped in the center, and then a plastic film is covered on the flowerpot opening for moisturizing. Each dose was repeated 12 times for a total of 12 experimental groups. In addition, fluazinam and benziothiazolinone granules in the embodiment 1 and the comparative example 1 are filled into a mesh bag with pores of 200 meshes, so that the medicine can be paved in the mesh bag, a binding opening is put into the flowerpot, the flowerpot is covered with 10cm of soil subjected to high-temperature baking treatment, 500mL of water is dripped in the center, and a plastic film is covered on the flowerpot opening for moisturizing. Each dose was repeated 12 times for a total of 2 experimental groups.
And (3) result detection: and (3) randomly selecting 3 pots each time after standing for 14 days, 30 days, 45 days and 60 days at the temperature of 25 ℃, taking out a powder charge agent net cloth bag, detecting the content and the weight of fluazinam and benziothiazolinone in soil by using a high performance liquid chromatography, calculating to obtain the release speed of fluazinam and benziothiazolinone granules in the soil, taking the average value of the data obtained by 3 groups of samples, and obtaining the results shown in the table 1 below.
The statistical method comprises the following steps: release rate of granule effective component in soil = (measured weight of effective component in soil/initial theoretical weight of effective component) ×100%
TABLE 1
As can be seen from table 1, in the soil experiment after the high-temperature baking treatment, fluazinam and benziothiazolinone granules obtained by the preparation method provided by the invention in embodiment 1 are slowly released in the soil along with time, the release dosage is relatively uniform, the release time can reach 60 days, and the purpose of controlled release is achieved; the release speed of fluazinam and benziothiazolinone granules prepared in the conventional method in comparative example 1 in soil is high, and the granules can be completely released on day 14.
Meanwhile, the experiment groups of the soil used in the embodiment 1 and the comparison 1 after being baked at high temperature are found that the release content of fluazinam and benziothiazolinone is obviously higher than that of the experiment groups of the soil used in the embodiment 1 and the comparison 1 without being baked at high temperature after the same days of treatment, and as a result, in the same bottom non-porous flowerpot, organic matters in the experiment soil obviously promote the degradation of fluazinam and benziothiazolinone, and in the table 1, the degradation rate of fluazinam and benziothiazolinone can reach more than 25% after the granules prepared by directly adding water into the mother powder are applied to the soil without being baked for 60 days according to the conventional method; after the fluazinam and the benziothiazolinone granules obtained by the preparation method provided by the invention are applied for the same application time, the granules can be slowly released in soil, so that a large amount of active ingredients of the granules are prevented from contacting with organic substances in the soil, the degradation problem of the fluazinam and the benziothiazolinone is obviously relieved, the degradation rate of the fluazinam and the benziothiazolinone can be reduced to be within 15% after the fluazinam and the benziothiazolinone are applied in the soil for 60 days, and the degradation problem of the active ingredients in the granules is obviously improved.
Test example 2
Test the control effect duration of fluazinam and benziothiazolinone granules on potato late blight
The test area is a potato farm in northeast, and is affected by potato late blight in the past year and severely lost.
The efficacy of the fluazinam and benziothiazolinone granules of examples 1, 2, 4, 6, 8, 10 and comparative examples 1-5 and comparative example 7 on the prevention and treatment effect of potato late blight is tested at Tian Nafen, and the planting area of each sample is tested to be 1 mu, and the specific steps comprise: in the bud emergence and flowering stage of the potatoes, 20g of various granular agents are accurately weighed according to the area of a test plot, the granules and fine sand are uniformly stirred, the granules are spread in the periphery of 5-15cm of the root of the potatoes (the application amount of the active ingredients of the granules is that of each mu of land), and other materials in the embodiment 1 after the active ingredients of fluazinam and benziothiazolinone are removed are used for replacing the granules to serve as blank treatment.
After the application of the agents according to the above protocol, the late blight spore suspensions were inoculated at a concentration of 1×105 spores/ml for 7 days, 14 days, 30 days, 45 days and 60 days, respectively. And (3) maintaining normal water and fertilizer management after inoculation, and when the blank control is fully ill, investigating the ill condition, and calculating the disease index and the prevention and treatment effect, wherein the result is shown in the following table 2.
The calculating method of the disease index and the prevention and treatment effect comprises the following steps:
TABLE 2
As can be seen from the treatment results in Table 2, the fluazinam and benziothiazolinone granules obtained by the preparation method provided by the invention can effectively control the occurrence of potato late blight after being applied in the bud bloom stage of potatoes, and the incidence rate of medicament treatment is obviously reduced. The test result shows that the prevention and treatment effect of the granules on diseases reaches a peak 14 days after the administration. After 45 days, the control effect of fluazinam and benziothiazolinone granules obtained by the preparation method provided by the invention on potato late blight is slightly reduced, but is far higher than that of a comparative example, the control effect can be kept for 60 days at more than 82%, the control effect is obvious, and the duration is longer; particularly, in comparative example 1, the granules prepared by the conventional method have high release speed in soil, part of active ingredients are easy to degrade in soil over time, and the active ingredients in the medicament are easy to be lost in a large amount along with rain leaching, so that the environment is seriously polluted while the duration is short. The comparison result shows that the fluazinam and the benziothiazolinone granules obtained by the preparation method provided by the invention have excellent long-acting controlled release effects, especially effectively relieve the problem that the benziothiazolinone and the fluazinam are easy to degrade and lose efficacy in soil, have fewer times and less dosage, save cost and reduce environmental pollution.
In conclusion, the fluazinam and the benziothiazolinone granules obtained by the preparation method provided by the invention have excellent control effect on potato late blight, have longer lasting period without affecting the control effect, can basically meet the whole growth period of the potato after the bud bloom stage, and most importantly, effectively relieve the problem that the benziothiazolinone and the fluazinam are easy to degrade and lose efficacy in soil, save cost and reduce environmental pollution, and have wide application prospect and market popularization value.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (8)
1. A fluazinam and benziothiazolinone containing granule is characterized in that: the granule comprises fluazinam, benziothiazolinone, a polymer film coating agent and auxiliary materials, wherein the polymer film coating agent comprises 4-20% of water-soluble film coating agent and 80-96% of water-insoluble film coating agent; the fluazinam accounts for 5-40% by weight, and the benziothiazolinone accounts for 1-10% by weight; the weight ratio of the benziothiazolinone to the fluazinam is 1: (1-10); the weight percentage of the polymer film coating agent is 10-20%; the water-soluble film coating agent is selected from one or two of polyethylene glycol, gelatin, gum arabic, sodium carboxymethyl cellulose and polyvinylpyrrolidone; the water-insoluble film coating agent is one or two of cellulose acetate phthalate emulsion, polyvinyl acetate emulsion, vinyl acetate-ethylene copolymer emulsion and acrylic acid copolymer emulsion; the weight ratio of the water-soluble film coating agent to the water-insoluble film coating agent is 1: (4-24).
2. The granule of claim 1, wherein the weight percentage of fluazinam is 15-37.5%, the weight percentage of benziothiazolinone is 2-5%, and the weight ratio of benziothiazolinone to fluazinam is 1: (5-10).
3. The granule as claimed in claim 2, wherein the polymer coating agent is 12-16% by weight.
4. The granule as claimed in claim 3, wherein the polymer film-forming agent comprises 8-12% of water-soluble film-forming agent and 88-92% of water-insoluble film-forming agent, and the weight ratio of the water-soluble film-forming agent to the water-insoluble film-forming agent is 1: (7.3-11.5).
5. The granule as claimed in any one of claims 1 to 4, wherein: the auxiliary materials comprise humic acid fertilizer, dispersing agent, wetting agent, solid carrier and warning color.
6. The granule of claim 5, wherein the humic acid fertilizer comprises humic acid, nitro humic acid, water soluble salts of humic acid and water soluble salts of nitro humic acid, and the water soluble salts comprise sodium salt, potassium salt, calcium salt, zinc salt, manganese salt and ammonium salt.
7. A process for preparing the granules according to any of claims 1 to 6, comprising the steps of:
(1) Mixing fluazinam, benziothiazolinone and auxiliary materials, and performing jet milling to form granule mother powder;
(2) Uniformly mixing a water-soluble film coating agent and a non-water-soluble film coating agent to form a film coating agent mixed solution;
(3) And adding the prepared film coating agent mixed solution into the granule master powder for adsorption and kneading, granulating, drying and screening to obtain fluazinam and benziothiazolinone granules.
8. Use of the granule according to any one of claims 1 to 6 for controlling potato late blight, black shank, scab.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103314968A (en) * | 2013-06-09 | 2013-09-25 | 江苏辉丰农化股份有限公司 | Bactericidal composition with synergistic effect |
| CN107258776A (en) * | 2017-06-29 | 2017-10-20 | 山东大农药业有限公司 | A kind of sustained releasing pesticide granule and preparation method thereof |
| CN107361080A (en) * | 2017-08-31 | 2017-11-21 | 广西沙田仙人滩农业投资有限公司 | A kind of black scurf of potato bactericide containing tolelofos-methyl |
| CN112616842A (en) * | 2021-01-11 | 2021-04-09 | 中国烟草总公司郑州烟草研究院 | Bactericidal composition for preventing and treating bacterial wilt, bactericide and application |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103314968A (en) * | 2013-06-09 | 2013-09-25 | 江苏辉丰农化股份有限公司 | Bactericidal composition with synergistic effect |
| CN107258776A (en) * | 2017-06-29 | 2017-10-20 | 山东大农药业有限公司 | A kind of sustained releasing pesticide granule and preparation method thereof |
| CN107361080A (en) * | 2017-08-31 | 2017-11-21 | 广西沙田仙人滩农业投资有限公司 | A kind of black scurf of potato bactericide containing tolelofos-methyl |
| CN112616842A (en) * | 2021-01-11 | 2021-04-09 | 中国烟草总公司郑州烟草研究院 | Bactericidal composition for preventing and treating bacterial wilt, bactericide and application |
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