CN115485303A - 包含CD28ζ和CD3ζ的CAR - Google Patents

包含CD28ζ和CD3ζ的CAR Download PDF

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Publication number
CN115485303A
CN115485303A CN202180032684.1A CN202180032684A CN115485303A CN 115485303 A CN115485303 A CN 115485303A CN 202180032684 A CN202180032684 A CN 202180032684A CN 115485303 A CN115485303 A CN 115485303A
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car
cells
domain
magea4
tumor
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CN202180032684.1A
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Chinese (zh)
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D·迪利略
T·C·米格尔
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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CN202180032684.1A 2020-05-05 2021-05-04 包含CD28ζ和CD3ζ的CAR Pending CN115485303A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063020177P 2020-05-05 2020-05-05
US63/020,177 2020-05-05
PCT/US2021/030625 WO2021226063A1 (en) 2020-05-05 2021-05-04 Car comprising cd28 zeta and cd3 zeta

Publications (1)

Publication Number Publication Date
CN115485303A true CN115485303A (zh) 2022-12-16

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CN202180032684.1A Pending CN115485303A (zh) 2020-05-05 2021-05-04 包含CD28ζ和CD3ζ的CAR

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US (3) US11826386B2 (https=)
EP (1) EP4146697A1 (https=)
JP (2) JP7648654B2 (https=)
KR (1) KR20230025662A (https=)
CN (1) CN115485303A (https=)
AU (1) AU2021266706A1 (https=)
BR (1) BR112022021871A2 (https=)
CA (1) CA3175491A1 (https=)
IL (1) IL297874A (https=)
MX (1) MX2022013898A (https=)
TW (1) TWI886268B (https=)
WO (1) WO2021226063A1 (https=)

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CN114302733A (zh) * 2019-07-03 2022-04-08 里珍纳龙药品有限公司 抗纽约食管鳞状细胞癌1(ny-eso-1)抗原结合蛋白及其使用方法
WO2024235355A1 (zh) * 2023-05-16 2024-11-21 清华大学 一种嵌合抗原受体、重组免疫细胞及用途

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EP4004049A1 (en) * 2019-07-24 2022-06-01 Regeneron Pharmaceuticals, Inc. Chimeric antigen receptors with mage-a4 specificity and uses thereof
KR20230025662A (ko) 2020-05-05 2023-02-22 리제너론 파마슈티칼스 인코포레이티드 Cd28 제타 및 cd3 제타를 포함하는 car
AU2022271212A1 (en) * 2021-05-04 2023-11-30 Regeneron Pharmaceuticals, Inc. Chimeric antigen receptors with mage-a4 specificity and uses thereof

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CN114302733B (zh) * 2019-07-03 2025-04-25 里珍纳龙药品有限公司 抗纽约食管鳞状细胞癌1(ny-eso-1)抗原结合蛋白及其使用方法
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