CN1154497C - 治疗肝脏肿瘤的方法和其中所用的药学组合物 - Google Patents

治疗肝脏肿瘤的方法和其中所用的药学组合物 Download PDF

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Publication number
CN1154497C
CN1154497C CNB988067609A CN98806760A CN1154497C CN 1154497 C CN1154497 C CN 1154497C CN B988067609 A CNB988067609 A CN B988067609A CN 98806760 A CN98806760 A CN 98806760A CN 1154497 C CN1154497 C CN 1154497C
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China
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vitamin
cancer
liver
compound
medicament
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Expired - Fee Related
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CNB988067609A
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English (en)
Chinese (zh)
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CN1261800A (zh
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��ά����ɭ��Ī��˹
戴维·劳森·莫利斯
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MRC HOLDING CO Ltd
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Unisearch Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CNB988067609A 1997-06-10 1998-06-10 治疗肝脏肿瘤的方法和其中所用的药学组合物 Expired - Fee Related CN1154497C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO7270A AUPO727097A0 (en) 1997-06-10 1997-06-10 Method of treatment of hepatoma and pharmaceutical compositions for use therein
AUPO7270 1997-06-10

Publications (2)

Publication Number Publication Date
CN1261800A CN1261800A (zh) 2000-08-02
CN1154497C true CN1154497C (zh) 2004-06-23

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ID=3801562

Family Applications (1)

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CNB988067609A Expired - Fee Related CN1154497C (zh) 1997-06-10 1998-06-10 治疗肝脏肿瘤的方法和其中所用的药学组合物

Country Status (8)

Country Link
US (1) US6486144B1 (OSRAM)
EP (1) EP1003523A4 (OSRAM)
JP (1) JP2002504100A (OSRAM)
KR (1) KR100382219B1 (OSRAM)
CN (1) CN1154497C (OSRAM)
AU (1) AUPO727097A0 (OSRAM)
WO (1) WO1998056387A1 (OSRAM)
ZA (1) ZA985028B (OSRAM)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6087350A (en) 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
AU765846B2 (en) * 1998-05-04 2003-10-02 Mrc Holdings Pty Limited Pharmaceutical composition
AUPP332898A0 (en) * 1998-05-04 1998-05-28 Unisearch Limited Pharmaceutical composition
US20030031670A1 (en) * 1999-11-08 2003-02-13 Jack R. Wands Diagnosis and treatment of malignant neoplasms
AU1917101A (en) * 1999-11-11 2001-06-06 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
DE10032587A1 (de) * 2000-07-05 2002-01-17 Bayer Ag 4-Alkoxy-cyclohexan-1-amino-carbonsäureester und Verfahren zu ihrer Herstellung
AU781168B2 (en) * 2001-01-26 2005-05-12 Pfizer Products Inc. Method of treating certain cancers using an estrogen agonist/antagonist
WO2002076454A1 (en) * 2001-03-26 2002-10-03 Unisearch Limited Method for treatment of cancer and compositions for use therein
JP2004026811A (ja) * 2002-04-30 2004-01-29 Kiyoshi Hashizume ビタミンｄ３誘導体を含有する抗癌作用を増強させるための薬剤
AU2002330482A1 (en) 2002-09-04 2004-03-29 Perseus Proteomics Inc. Method of diagnosing cancer by detecting gpc3
WO2004047673A2 (en) * 2002-11-21 2004-06-10 Novacea, Inc. Treatment of liver disease with active vitamin d compounds
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
WO2005027928A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism
WO2005027922A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vitamin d derivatives for the treatment of hypogonadism or andropause
AU2004273658A1 (en) * 2003-09-19 2005-03-31 Wisconsin Alumni Research Foundation (Warf) Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin D derivatives and an estrogen agonist/antagonist
WO2005027918A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a cyclooxgenase-2 inhibitor
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
JP4248544B2 (ja) * 2005-12-19 2009-04-02 株式会社椿本チエイン 伝動装置用可動ガイド
EP2464357B1 (en) 2009-08-14 2019-05-22 Berg LLC Vitamin d3 and analogs thereof for treating alopecia
CA2909941A1 (en) 2013-04-24 2014-10-30 Salk Institute For Biological Studies Vitamin d receptor/smad genomic circuit gates fibrotic response
BR112015030518A2 (pt) * 2013-06-05 2017-08-29 Salk Inst For Biological Studi Composição farmacêutica, uso de um ou mais agonistas do receptor da vitamina d (vdr), e, método para a redução da atividade biológica do ligante 12 do motivo c-x-c (cxcl12)
JP2016124818A (ja) * 2014-12-26 2016-07-11 日本化薬株式会社 転移性肝癌治療薬及び転移性肝癌の治療方法
WO2016167977A1 (en) 2015-04-14 2016-10-20 Mayo Foundation For Medical Education And Research Methods and materials for delivering agents to liver tissue
WO2019023149A1 (en) 2017-07-24 2019-01-31 Salk Institute For Biological Studies USE OF BROMODOMAIN-CONTAINING PROTEIN-9 ANTAGONISTS IN ASSOCIATION WITH VITAMIN D RECEPTOR AGONISTS IN THE TREATMENT OF DIABETES
CN116059364B (zh) * 2021-11-04 2025-07-11 上海健康医学院 Dhcr7下调剂在减弱酒精诱导的肝脏肿瘤中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296800B1 (en) * 1987-06-23 1991-10-16 Yamanouchi Pharmaceutical Co. Ltd. Vitamin d3 derivatives
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
US5798345A (en) * 1990-09-21 1998-08-25 Bone Care International, Inc. Method of inhibiting the hyperproliferation of malignant cells
ATE191712T1 (de) * 1993-07-09 2000-04-15 Theramex Neue strukturelle vitamin d derivate
US5856189A (en) * 1997-01-07 1999-01-05 The Regents Of The University Of Michigan Cell culture model for drug bioavailability

Also Published As

Publication number Publication date
KR20010013651A (ko) 2001-02-26
JP2002504100A (ja) 2002-02-05
CN1261800A (zh) 2000-08-02
WO1998056387A1 (en) 1998-12-17
ZA985028B (en) 1999-01-25
US6486144B1 (en) 2002-11-26
KR100382219B1 (ko) 2003-04-26
AUPO727097A0 (en) 1997-07-03
EP1003523A4 (en) 2001-08-22
HK1030144A1 (en) 2001-04-27
EP1003523A1 (en) 2000-05-31

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