CN115445057A - Drug delivery catheter capable of improving drug absorption effect - Google Patents
Drug delivery catheter capable of improving drug absorption effect Download PDFInfo
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- CN115445057A CN115445057A CN202211076849.8A CN202211076849A CN115445057A CN 115445057 A CN115445057 A CN 115445057A CN 202211076849 A CN202211076849 A CN 202211076849A CN 115445057 A CN115445057 A CN 115445057A
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- balloon
- drug
- cylinder
- plate
- fixedly installed
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B13/00—Machines or plants for applying liquids or other fluent materials to surfaces of objects or other work by spraying, not covered by groups B05B1/00 - B05B11/00
- B05B13/02—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work
- B05B13/0221—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work characterised by the means for moving or conveying the objects or other work, e.g. conveyor belts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B13/00—Machines or plants for applying liquids or other fluent materials to surfaces of objects or other work by spraying, not covered by groups B05B1/00 - B05B11/00
- B05B13/02—Means for supporting work; Arrangement or mounting of spray heads; Adaptation or arrangement of means for feeding work
- B05B13/0278—Arrangement or mounting of spray heads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B14/00—Arrangements for collecting, re-using or eliminating excess spraying material
- B05B14/40—Arrangements for collecting, re-using or eliminating excess spraying material for use in spray booths
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B16/00—Spray booths
- B05B16/20—Arrangements for spraying in combination with other operations, e.g. drying; Arrangements enabling a combination of spraying operations
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/04—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
- B05D3/0406—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases the gas being air
- B05D3/0413—Heating with air
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P70/00—Climate change mitigation technologies in the production process for final industrial or consumer products
- Y02P70/10—Greenhouse gas [GHG] capture, material saving, heat recovery or other energy efficient measures, e.g. motor control, characterised by manufacturing processes, e.g. for rolling metal or metal working
Abstract
The invention discloses a drug delivery catheter capable of improving drug absorption effect, and relates to the technical field of medical instruments, and the drug delivery catheter comprises a balloon, a first slender member and a second slender member, wherein the balloon is simultaneously connected with the far end of the first slender member and the far end of the second slender member, the end part of the balloon is connected with a nose cone, and a plurality of electrode pairs are arranged in the balloon; coating at least one drug coating on the surface of the balloon by an ultrasonic spraying device; the ultrasonic spraying equipment comprises a box body and a base, wherein the box body is fixedly arranged at the top of the base, and the middle part of the box body is of a hollow structure to form a spraying chamber; the drug loss of the drug balloon in the conveying process in the operation can be effectively reduced, and the drug loss of the outermost layer and the far end of the balloon can be reduced; this application passes through ultrasonic spraying equipment's setting, can realize automatic cross transport, carries out spraying and stoving simultaneously, improves the work efficiency of whole technology.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a drug delivery catheter capable of improving drug absorption effect.
Background
Intravascular topical administration refers to the act of treating a particular human blood vessel with a therapeutic agent without utilizing the body's circulatory system. This allows the drug to interact only with the target area, thereby improving the therapeutic effect and avoiding possible damage to healthy non-targeted tissue. In recent years, the delivery of antiproliferative drugs to atherosclerotic vessels reopened by balloon angioplasty has progressed rapidly using a method of drug-infused balloon (DIB) catheters.
The invention discloses a drug delivery catheter with a novel structure and a preparation method thereof in the patent number of 202110161466X, and discloses a method for preparing the drug delivery catheter, wherein an assembled inflatable component is taken out, the outer surface of a balloon is immersed into a drug coating solution after being chemically etched, the balloon is taken out and aired and then immersed into a solution of a bioabsorbable surface wrapping material, so that drug microcapsules are formed on the surface of the balloon, and the inflatable component with the drug microcapsules is dried under constant temperature and humidity; the drug microcapsules can be delivered to target blood vessels through the saccule, so that the drug delivery efficiency and the utilization rate are obviously improved, the drug can be released to target pathological changes for a long time, and the smoothness of the blood vessels is maintained for a long time;
in patent No. 2019113742996, it is disclosed that a low drug content coating solution is sprayed onto a predetermined region of a low drug content coating on the surface of a balloon catheter, and dried to obtain a low drug content coating; s4, spraying the high-drug-content coating solution to a preset area of the high-drug-content coating, and drying to obtain the high-drug-content coating; the high-drug-content coating preset area is positioned on the surface of the balloon catheter or the surface of the dried low-drug-content coating; s5, spraying the low-drug-content coating solution to a preset area of a preset low-drug-content coating according to the requirement, and drying to obtain another low-drug-content coating; the predetermined region of the low drug content coating is located on the surface and/or at both ends of the high drug content coating. Through the provided medicine balloon catheter with the coatings with different medicine contents, the medicine loss of the medicine balloon in the conveying process in the operation can be effectively reduced, the medicine loss of the outermost layer and the far end of the balloon is reduced, the medicine residue on the surface and the near end of the balloon in the withdrawing process of the medicine balloon after the operation is finished is reduced, and the medicine damage to the non-target lesion part is reduced.
Although the above patents disclose two process steps of spraying a drug on the surface of the balloon and drying the balloon, the two process steps are independent and cannot be performed simultaneously, resulting in low working efficiency.
Disclosure of Invention
The invention aims to provide a drug delivery catheter capable of improving drug absorption effect, and solves the following technical problems: in the prior art, two process steps of spraying medicine on the surface of the balloon and drying the balloon are disclosed, but the two process steps are independent and cannot be carried out simultaneously, so that the working efficiency is low.
The purpose of the invention can be realized by the following technical scheme:
a drug delivery catheter capable of improving drug absorption effect comprises a balloon, a first elongated member and a second elongated member, wherein the balloon is connected with the distal end of the first elongated member and the distal end of the second elongated member at the same time, a nose cone is connected with the end part of the balloon, and a plurality of electrode pairs are arranged inside the balloon; coating at least one drug coating on the surface of the balloon by an ultrasonic spraying device;
the ultrasonic spraying equipment comprises a box body and a base, wherein the box body is fixedly installed at the top of the base, the middle part of the box body is of a hollow structure to form a spraying chamber, conveying belts are arranged on two sides of the spraying chamber, and drying chambers are arranged on the other two sides of the spraying chamber;
the two ends of the top of the base are rotatably connected with a first rotating shaft, a first gear is sleeved on the first rotating shaft, a first chain is sleeved on the first gear, the first chain penetrates through two symmetrically arranged movable plates, a connecting plate is fixedly installed between the two movable plates, a supporting mechanism is arranged on the connecting plate, guide wheels are arranged at the bottoms of the movable plates, and the guide wheels slide with guide rails on the base;
the top fixed mounting of box has motor one, motor one drives two pivots of two symmetry settings through the chain and rotates, pivot two sets up the top at the box, two gears are installed to the symmetry on the pivot two, have cup jointed chain two on the gear, two fixed mounting has baffle two between the chain two, the top fixed mounting of baffle two has baffle one, baffle one slides with baffle two and pegs graft.
As a further scheme of the invention: the supporting mechanism comprises a supporting plate, a rotary plate is arranged on the supporting plate, a telescopic rod is fixedly mounted on the rotary plate, a placing plate is fixedly mounted on the telescopic rod, and a first three suckers are arranged on the placing plate.
As a further scheme of the invention: the movable clamping plate is adjusted through bolts and is matched with the fixed plate.
As a further scheme of the invention: the drying device is characterized in that a heater is fixedly mounted on the inner wall of the top of the drying chamber, a trapezoidal cover is arranged outside the heater, a circulating fan is arranged at the lower end of one side of the drying chamber, a circulating pipe is mounted on the circulating fan, and the circulating pipe is inserted into the trapezoidal cover.
As a further scheme of the invention: and a spraying mechanism is fixedly arranged in the spraying chamber.
As a further scheme of the invention: spraying mechanism includes horizontal installation's slide rail one, one side fixed mounting of slide rail one has cylinder one, the tailpiece of the piston rod portion fixed mounting of cylinder one has vertical setting slide rail two, slide rail two and slide rail one sliding connection, one side fixed mounting of slide rail two has the cylinder, fixed mounting has the lifter plate on the piston rod of cylinder, cylinder three is installed to one side symmetry of lifter plate, the tailpiece of the piston rod portion fixed mounting of cylinder three has double-end cylinder, equal fixed mounting has the fly leaf on double-end cylinder's the both sides piston rod, the bottom fixed mounting of fly leaf has the sucking disc, one side of double-end cylinder is still fixed mounting has vertical setting cylinder four, the tailpiece of the piston rod portion fixed mounting of cylinder four has the ultrasonic spray head.
As a further scheme of the invention: the inside of telescopic link is provided with telescopic cavity fluid-discharge tube, place the board and be hollow structure, and place and evenly seted up a plurality of feed liquor holes on the board, the carousel is hollow structure.
The invention has the beneficial effects that:
(1) The method comprises the following steps of coating a drug coating on the surface of a balloon through ultrasonic spraying equipment; the drug loss of the drug balloon in the conveying process in the operation can be effectively reduced, and the drug loss of the outermost layer and the far end of the balloon can be reduced;
(2) This application passes through ultrasonic spraying equipment's setting, can realize automatic cross transport, carries out spraying and stoving simultaneously, improves the work efficiency of whole technology.
Drawings
The invention will be further described with reference to the accompanying drawings.
FIG. 1 is a schematic view of the overall construction of a drug delivery catheter of the present invention;
FIG. 2 is a schematic elevation view of the ultrasonic spray apparatus of the present invention;
FIG. 3 is a schematic view of the back structure of the ultrasonic spraying apparatus of the present invention;
FIG. 4 is a schematic view of the overall construction of the spray mechanism of the present invention;
FIG. 5 is a schematic top view of the base of the present invention;
FIG. 6 is a schematic view of the interior of the drying chamber of the present invention in elevation;
fig. 7 is a schematic view of the inside side view of the drying chamber of the present invention.
In the figure: 1. a box body; 2. a drying chamber; 21. a trapezoidal cover; 22. a heater; 23. a sealing plate; 24. a circulating fan; 25. a circulation pipe; 3. a spray chamber; 31. a spraying mechanism; 311. a first slide rail; 312. a first cylinder; 313. a second slide rail; 314. a lifting plate; 315. a third air cylinder; 316. a double-ended cylinder; 317. a movable plate; 318. a suction cup; 319. a cylinder IV; 320. an ultrasonic spray head; 32. a conveyor belt; 4. a base; 41. a first rotating shaft; 42. a first gear; 43. a first chain; 44. a guide rail; 45. moving the plate; 46. a movable splint; 47. a fixing plate; 48. a connecting plate; 49. a guide wheel; 51. a support plate; 52. a telescopic rod; 53. placing the plate; 54. a first sucker; 61. a first motor; 62. a chain cage; 63. a second rotating shaft; 64. a second chain; 65. a first clapboard; 66. and a second clapboard.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-7, the present invention is a drug delivery catheter capable of improving drug absorption effect, comprising a balloon 101, a first elongated member 103, and a second elongated member 102, wherein the balloon 101 is connected to a distal end of the first elongated member 103 and a distal end of the second elongated member 102, a nose cone 106 is connected to an end of the balloon 101, and a plurality of electrode pairs 104 and 105 are disposed inside the balloon 101; the surface of the balloon 101 is coated with at least one drug coating by an ultrasonic spraying device; can effectively reduce the drug loss of the drug balloon in the process of delivery in the operation and reduce the drug loss of the outermost layer and the far end of the balloon.
The ultrasonic spraying equipment comprises a box body 1 and a base 4, wherein the box body 1 is fixedly installed at the top of the base 4, the middle part of the box body 1 is of a hollow structure to form a spraying chamber 3, conveying belts 32 are arranged on two sides of the spraying chamber 3, a drying chamber 2 is arranged on the other two sides of the spraying chamber 3, and a detachable sealing plate 23 is arranged on one side of the drying chamber 2, so that the drying chamber is convenient to detach and the internal structure is maintained;
the top both ends of base 4 are rotated and are connected with pivot one 41, and one of them pivot one 41 is by motor drive, the first gear 42 that has cup jointed on the pivot one 41, the first chain 43 that has cup jointed on the gear one 42, the first chain 43 runs through the movable plate 45 that two symmetries set up, two fixed mounting has connecting plate 48 between the movable plate 45, be provided with supporting mechanism on the connecting plate 48, the bottom of movable plate 45 is provided with guide pulley 49, guide pulley 49 slides with guide rail 44 on the base 4, and the movable plate 45 of being convenient for slides on guide rail 44
The top fixed mounting of box 1 has a motor 61, two 63 rotations of pivot that two symmetries set up are driven through the chain to motor 61, are provided with chain cover 62 outside the chain, two 63 settings are at the top of box 1 in the pivot, two gears are installed to the symmetry on two 63 of pivots, have cup jointed two 64 of chains on the gear, two fixed mounting has two 66 of baffle between two 64 of chains, the top fixed mounting of two 66 of baffle has a baffle 65, the setting of two 66 slip pegs graft of baffle 65 and baffle does not have the clearance, can play good sealed effect, improves its inside drying efficiency.
Firstly, the balloon 101 is conveyed by the conveyor belt 32, then the balloon is sucked and placed on the placing plate 53 by the spraying mechanism 31 and is sucked by the first sucker 54, then the surface of the balloon is sprayed by the ultrasonic sprayer 320, after the spraying, the first starting motor 61 drives the second rotating shaft 63 to rotate, the second rotating shaft 63 drives the second chain 64 to rotate, so that the second partition plate 66 is driven to ascend, meanwhile, the motor is started to drive the first rotating shaft 41 to rotate, so that the first gear 42 and the first chain 43 are driven to rotate, the first chain 43 drives the two moving plates 45 to move, one of the two moving plates enters the drying chamber 2 to be dried, the other waits for the balloon 101 to be placed, and then the second partition plate 66 is put down to play a good sealing role, so that the drying effect is better, and the working efficiency of the whole equipment is high; the above work is repeated.
The supporting mechanism comprises a supporting plate 51, a rotary table is arranged on the supporting plate 51, the supporting plate 51 is driven to rotate conveniently in the drying process, the drying is more uniform, a telescopic rod 52 is fixedly arranged on the rotary table, the height of the supporting plate 51 is convenient to adjust, a placing plate 53 is fixedly arranged on the telescopic rod 52, a first three sucking disc 54 is arranged on the placing plate 53, two sides and the center bottom of the balloon 101 can be fixed through the first three sucking disc 54, the leveling of the balloon is guaranteed, and the spraying is more uniform.
Fixed mounting has fixed plate 47 on the connecting plate 48, sliding connection has movable splint 46 on the movable plate 45, movable splint 46 passes through the bolt regulation, movable splint 46 and fixed plate 47 adaptation, through the setting of movable splint 46 and fixed plate 47, the installation of being convenient for and dismantlement backup pad 51.
The top inner wall fixed mounting of drying chamber 2 has heater 22, the outside of heater 22 is provided with trapezoidal cover 21, one side lower extreme of drying chamber 2 is provided with circulating fan 24, install circulating pipe 25 on the circulating fan 24, in trapezoidal cover 21 was inserted to circulating pipe 25, through the setting of above-mentioned structure, the heat from the top down formed a endless heating system, can improve drying efficiency, can improve thermal recycling, avoided thermal waste.
The spraying mechanism 31 is fixedly arranged in the spraying chamber 3. The spraying mechanism 31 comprises a horizontally-mounted first sliding rail 311, a first cylinder 312 is fixedly mounted on one side of the first sliding rail 311, a second vertically-arranged sliding rail 313 is fixedly mounted at the end of a piston rod of the first cylinder 312, the second sliding rail 313 is slidably connected with the first sliding rail 311, a cylinder is fixedly mounted on one side of the second sliding rail 313, a lifting plate 314 is fixedly mounted on a piston rod of the cylinder, a third cylinder 315 is symmetrically mounted on one side of the lifting plate 314, a double-headed cylinder 316 is fixedly mounted at the end of a piston rod of the third cylinder 315, movable plates 317 are fixedly mounted on piston rods on two sides of the double-headed cylinder 316, a suction cup 318 is fixedly mounted at the bottom of each movable plate 317, a fourth vertically-arranged cylinder 319 is also fixedly mounted on one side of the double-headed cylinder 316, and an ultrasonic spray head 320 is fixedly mounted at the end of a piston rod of the fourth cylinder 319;
the first driving cylinder 312 drives the second sliding rail 313 to move, meanwhile, the first driving cylinder is started to drive the lifting plate 314 to lift, finally, the third driving cylinder 315 drives the double-head cylinder 316 to move, finally, the double-head cylinder 316 is driven to drive the movable plate 317 to move relatively or oppositely, further, the suction cup 318 is driven to move, the balloons 101 with different sizes can be conveniently sucked, the balloons are placed on the placing plate 53 from the conveying belt, and finally, multi-directional spraying is carried out through the ultrasonic spray head 320 to achieve the required shape.
The inside of telescopic link 52 is provided with telescopic cavity fluid-discharge tube, place board 53 and be hollow structure, and place and evenly seted up a plurality of feed liquor holes on the board 53, the carousel is hollow structure, and through the setting of this structure, through the feed liquor hole with spraying liquid recovery, then through the cavity fluid-discharge tube, flow in the carousel, save, the recycle of being convenient for.
The working principle of the invention is as follows: balloon 101 is first conveyed by conveyor belt 32; the first driving cylinder 312 drives the second sliding rail 313 to move, meanwhile, the first driving cylinder is started to drive the lifting plate 314 to lift, finally, the third driving cylinder 315 drives the double-head cylinder 316 to move, finally, the double-head cylinder 316 is driven to drive the movable plate 317 to move relatively or oppositely, further, the suction cup 318 is driven to move, so that the balloons 101 with different sizes can be conveniently sucked, the balloons are placed on the placing plate 53 from the conveying belt, and finally, multi-directional spraying is carried out through the ultrasonic spray head 320 to achieve the required shape;
after spraying, a first motor 61 is started to drive a second rotating shaft 63 to rotate, the second rotating shaft 63 drives a second chain 64 to rotate so as to drive a second partition plate 66 to ascend, meanwhile, the first motor is started to drive a first rotating shaft 41 to rotate so as to drive a first gear 42 and a first chain 43 to rotate, the first chain 43 drives two moving plates 45 to move, one of the two moving plates enters the drying chamber 2 for drying, the other one waits for placing the saccule 101, then the second partition plate 66 is put down to play a good sealing role, so that the drying effect is better, and the working efficiency of the whole equipment is high; the above operation is repeated.
Although one embodiment of the present invention has been described in detail, the description is only for the purpose of illustrating the preferred embodiments of the present invention and should not be taken as limiting the scope of the invention. All equivalent changes and modifications made within the scope of the present invention shall fall within the scope of the present invention.
Claims (7)
1. A drug delivery catheter capable of improving drug absorption effect comprises a balloon, a first elongated member and a second elongated member, wherein the balloon is connected with the distal end of the first elongated member and the distal end of the second elongated member at the same time, a nose cone is connected with the end of the balloon, and a plurality of electrode pairs are arranged inside the balloon; the balloon is characterized in that the surface of the balloon is coated with at least one drug coating by an ultrasonic spraying device;
the ultrasonic spraying equipment comprises a box body and a base, wherein the box body is fixedly installed at the top of the base, the middle part of the box body is of a hollow structure to form a spraying chamber, conveying belts are arranged on two sides of the spraying chamber, and drying chambers are arranged on the other two sides of the spraying chamber;
the two ends of the top of the base are rotatably connected with a first rotating shaft, a first gear is sleeved on the first rotating shaft, a first chain is sleeved on the first gear, the first chain penetrates through two symmetrically arranged movable plates, a connecting plate is fixedly installed between the two movable plates, a supporting mechanism is arranged on the connecting plate, guide wheels are arranged at the bottoms of the movable plates, and the guide wheels slide with guide rails on the base;
the top fixed mounting of box has motor one, motor one drives two pivots of two symmetry settings through the chain and rotates, pivot two sets up the top at the box, two gears are installed to the symmetry on the pivot two, have cup jointed chain two on the gear, two fixed mounting has baffle two between the chain two, the top fixed mounting of baffle two has baffle one, baffle one slides with baffle two and pegs graft.
2. The drug delivery catheter capable of improving drug absorption effect according to claim 1, wherein the supporting mechanism comprises a supporting plate, a rotating disc is arranged on the supporting plate, a telescopic rod is fixedly arranged on the rotating disc, a placing plate is fixedly arranged on the telescopic rod, and a first three suction cups are arranged on the placing plate.
3. The drug delivery catheter capable of improving drug absorption effect according to claim 1, wherein a fixed plate is fixedly installed on the connecting plate, a movable clamping plate is slidably connected to the movable plate, the movable clamping plate is adjusted through a bolt, and the movable clamping plate is matched with the fixed plate.
4. The drug delivery catheter capable of improving the drug absorption effect according to claim 1, wherein a heater is fixedly installed on the inner wall of the top of the drying chamber, a trapezoidal cover is installed outside the heater, a circulating fan is installed at the lower end of one side of the drying chamber, and a circulating pipe is installed on the circulating fan and inserted into the trapezoidal cover.
5. The drug delivery catheter of claim 1, wherein the spraying mechanism is fixedly installed inside the spraying chamber.
6. The drug delivery catheter capable of improving the drug absorption effect according to claim 5, wherein the spraying mechanism comprises a horizontally-installed first sliding rail, a first cylinder is fixedly installed on one side of the first sliding rail, a vertically-arranged second sliding rail is fixedly installed on the end portion of a piston rod of the first cylinder, the second sliding rail is slidably connected with the first sliding rail, a cylinder is fixedly installed on one side of the second sliding rail, a lifting plate is fixedly installed on a piston rod of the cylinder, a third cylinder is symmetrically installed on one side of the lifting plate, a double-end cylinder is fixedly installed on the end portion of a piston rod of the third cylinder, movable plates are fixedly installed on piston rods on two sides of the double-end cylinder, suckers are fixedly installed on the bottom of the movable plates, a fourth cylinder is fixedly installed on one side of the double-end cylinder, and an ultrasonic sprayer is fixedly installed on the end portion of a piston rod of the fourth cylinder.
7. The drug delivery catheter capable of improving drug absorption effect according to claim 2, wherein a retractable hollow drainage tube is arranged inside the retractable rod, the placing plate is of a hollow structure, a plurality of liquid inlet holes are uniformly formed in the placing plate, and the rotating disc is of a hollow structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211076849.8A CN115445057B (en) | 2022-09-05 | 2022-09-05 | Ultrasonic spraying equipment of drug delivery catheter capable of improving drug absorption effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211076849.8A CN115445057B (en) | 2022-09-05 | 2022-09-05 | Ultrasonic spraying equipment of drug delivery catheter capable of improving drug absorption effect |
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| Publication Number | Publication Date |
|---|---|
| CN115445057A true CN115445057A (en) | 2022-12-09 |
| CN115445057B CN115445057B (en) | 2023-08-08 |
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| CN202211076849.8A Active CN115445057B (en) | 2022-09-05 | 2022-09-05 | Ultrasonic spraying equipment of drug delivery catheter capable of improving drug absorption effect |
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| CN208408896U (en) * | 2018-06-27 | 2019-01-22 | 普睿玛智能科技（苏州）有限公司 | A kind of double-station heat-exchangers of the plate type laser welding apparatus |
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| CN212603490U (en) * | 2020-04-09 | 2021-02-26 | 深圳市鄱阳科技有限公司 | Double-station hot-pressing device for touch screen conductive film and flexible circuit board |
| CN212681466U (en) * | 2020-05-06 | 2021-03-12 | 乌鲁木齐市微嘉吉鸿建材有限公司 | Spraying device is used in production of fire door plant |
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| CN216440924U (en) * | 2021-11-26 | 2022-05-06 | 潍坊创智涂装科技有限公司 | Double-station automatic spraying machine |
| CN114682467A (en) * | 2022-04-15 | 2022-07-01 | 河北京东管业有限公司 | Surface paint-spraying and anti-corrosion treatment process for nodular cast iron pipe |
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| CN105328440A (en) * | 2015-12-08 | 2016-02-17 | 焦作欣扬程煤矿设备有限公司 | Novel vertical disassembly and assembly device of hydraulic support hydraulic cylinder |
| JP2018177392A (en) * | 2017-04-04 | 2018-11-15 | 東レエンジニアリング株式会社 | Substrate holding device |
| CN107116821A (en) * | 2017-04-11 | 2017-09-01 | 中国重型机械研究院股份公司 | A kind of three station double moldses conveyers and its Transfer method |
| CN108295361A (en) * | 2018-02-23 | 2018-07-20 | 北京东方金荣超声电器有限公司 | A kind of medicinal balloon coating equipment |
| CN208408896U (en) * | 2018-06-27 | 2019-01-22 | 普睿玛智能科技（苏州）有限公司 | A kind of double-station heat-exchangers of the plate type laser welding apparatus |
| CN211914285U (en) * | 2020-01-15 | 2020-11-13 | 深圳市壹零壹汽车科技有限公司 | Spraying and light-curing integrated machine of hand plate model |
| CN212603490U (en) * | 2020-04-09 | 2021-02-26 | 深圳市鄱阳科技有限公司 | Double-station hot-pressing device for touch screen conductive film and flexible circuit board |
| CN212681466U (en) * | 2020-05-06 | 2021-03-12 | 乌鲁木齐市微嘉吉鸿建材有限公司 | Spraying device is used in production of fire door plant |
| CN112535793A (en) * | 2020-11-19 | 2021-03-23 | 融冲(深圳)生物医疗科技有限责任公司 | Preparation method and application of drug-coated balloon catheter |
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| CN214864471U (en) * | 2021-03-17 | 2021-11-26 | 常州远清光电科技有限公司 | Coating equipment for heat exchanger production |
| CN216330205U (en) * | 2021-09-26 | 2022-04-19 | 广东华焯激光科技有限公司 | Welding jig and welding equipment |
| CN216440924U (en) * | 2021-11-26 | 2022-05-06 | 潍坊创智涂装科技有限公司 | Double-station automatic spraying machine |
| CN114682467A (en) * | 2022-04-15 | 2022-07-01 | 河北京东管业有限公司 | Surface paint-spraying and anti-corrosion treatment process for nodular cast iron pipe |
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