CN108295361A - A kind of medicinal balloon coating equipment - Google Patents
A kind of medicinal balloon coating equipment Download PDFInfo
- Publication number
- CN108295361A CN108295361A CN201810155365.XA CN201810155365A CN108295361A CN 108295361 A CN108295361 A CN 108295361A CN 201810155365 A CN201810155365 A CN 201810155365A CN 108295361 A CN108295361 A CN 108295361A
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- China
- Prior art keywords
- foley
- clamp head
- coating equipment
- sacculus
- tube fixture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
- A61M2025/1031—Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Manufacturing & Machinery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The present invention relates to the field of medical instrument technology, disclose a kind of medicinal balloon coating equipment, including spray booth, ultrasonic generator, drug delivery device, carrier gas device, clamping device and retracting device for sacculus to be sprayed to be clamped, clamping device includes the first foley's tube fixture and the second foley's tube fixture, and the second foley's tube fixture can be with respect to the first foley's tube clamp movement；Carrier gas device includes the gas-carrier pipeline being connected to the air source and drier being sequentially arranged in gas-carrier pipeline, doping mechanism and heating mechanism；Ultrasonic generator includes ultrasonic generator and the ultrasonic nozzle that is connect with the ultrasonic generator, ultrasonic nozzle is connected with drug delivery device and gas-carrier pipeline respectively, the drug of drug delivery device is atomized by the ultrasonic wave generated by ultrasonic generator, and is ejected on sacculus to be sprayed by gas-carrier pipeline.The quality for the medication coat that the medicinal balloon coating equipment is produced is high, production efficiency is high and will not injure the mandrel catheter surface of sacculus to be sprayed.
Description
Technical field
The present invention relates to the field of medical instrument technology, and in particular to a kind of medicinal balloon coating equipment.
Background technology
In recent years, a variety of insertion types for being loaded with medication coat or plant are had been developed that for the various origin causes of formation of Restenosis
Enter formula medical instrument.Include mainly medicinal balloon and bracket for eluting medicament, this kind of equipment surfaces are uniformly coated with polymer, and
Additional layer has medicative medication coat on polymer coating, and sacculus or holder with medication coat enter blood vessel
Afterwards, drug gradually slow release, to achieve the purpose that treat and prevent Restenosis.Currently, more and more people
The research for paying close attention to and being dedicated to medicinal balloon, relative to bracket for eluting medicament, medicinal balloon can not indwelling in human body, in this way
Greatly reduce various risks.
The key factor for wherein influencing medicinal balloon validity has：The adhesive force of medication coat and the crystal habit of drug.
When preparing medicinal balloon catheter, different coat preparing technologies and technique can produce the adhesive force and drug crystallization form of coating
Raw very big influence.Current main preparation method has infusion process, microinjection and spray coating method.Wherein utilize ultrasonic spray
Coating production of the ultrasonic spray coating method of technology as medicinal balloon, it is considered to be current most effective insertion type or implanted
Medical instrument medicinal coating production.However the work of the current existing medicinal balloon coating equipment using ultrasonic spray method
It is low to make less efficient, medication coat of poor quality and the degree of automation.
Invention content
(1) technical problems to be solved
The object of the present invention is to provide one kind, work efficiency is high, and the medicinal balloon coating equipment that medication coat quality is high.
(2) technical solution
In order to solve the above technical problem, the present invention provides a kind of medicinal balloon coating equipment comprising spray booth surpasses
Generating device, drug delivery device, carrier gas device, in the spray booth for be clamped sacculus to be sprayed clamping device and
Retracting device, wherein
The clamping device includes the first foley's tube fixture and the second foley's tube fixture, the second foley's tube folder
Tool can the relatively described first foley's tube clamp movement, the first foley's tube fixture include first support and with it is described
First clamp head of mandrel conduit of the first support connection for the sacculus first end to be sprayed to be clamped, second sacculus are led
Pipe clamp includes second support and connect with the second support to lead for the mandrel of the sacculus second end to be sprayed to be clamped
Second clamp head of pipe；The first foley's tube fixture further includes for driving first clamp head around first fixture
The first actuator and the second foley's tube fixture of line rotation between head and second clamp head further include using
In driving line rotation between first clamp head and second clamp head of second clamp head and with described the
The rotation of one clamp head keeps the second synchronous actuator；
The carrier gas device includes gas-carrier pipeline for being connected to air source and is successively set on the gas-carrier pipeline
Drier, doping mechanism and heating mechanism；
The ultrasonic generator includes ultrasonic generator and the ultrasonic nozzle that is connect with the ultrasonic generator, described super
Sound nozzle is connected with the drug delivery device and the gas-carrier pipeline respectively, will by the ultrasonic wave that the ultrasonic generator generates
The drug of the drug delivery device supply is atomized, and is ejected on the sacculus to be sprayed by gas-carrier pipeline；
The retracting device is connect with the spray booth, for recycling the indoor excess waste of spraying.
Wherein, further include guide rail, the first foley's tube fixture is fixed, and the second foley's tube fixture passes through
Be slidably connected with the guide rail and with the first foley's tube fixture relative motion, the second foley's tube fixture further includes
For the relatively described guide rail of the second foley's tube fixture to be kept locked lockable mechanism.
Wherein, the mandrel conduit of the sacculus first end to be sprayed includes ring duct portion and linear conduit part, and described
One clamp head includes coil pipe clamp head and the straight tube clamp head that is connect with the coil pipe clamp head, and the straight tube clamp head is located at
Between the coil pipe clamp head and second clamp head, the coil pipe clamp head is described for accommodating the ring duct portion
Straight tube clamp head is for being clamped the linear conduit part.
Wherein, the coil pipe clamp head includes the first backing board and first upper cover hinged with the side of first backing board
Plate is provided with the arc groove for placing the ring duct portion, first backing board and hinge on first backing board
The opposite side in side is connect to connect by snak link with first upper cover plate.
Wherein, the backing board is made of soft plastic material or the metal material coated with teflon coatings.
Wherein, the straight tube clamp head includes the second backing board and second upper cover plate hinged with second backing board,
The linear groove for placing the linear conduit part, second backing board and hinged side are provided on second backing board
Opposite side is connect with second upper cover plate by thread.
Wherein, elasticity layer is set in the linear groove.
Wherein, the first foley's tube fixture further includes the clamping of the air inlet terminal for the sacculus to be sprayed to be clamped
Part.
Wherein, further include for the air charging system to the inflated to be sprayed, the air charging system includes air supply source
And the supply air line being connect with the air supply source, and the free end of the supply air line be provided with for the air inlet terminal
Rule check valve of connection.
Wherein, second clamp head uses scroll chuck structure.
Wherein, the first foley's tube fixture further includes the first support being connect with first clamp head, and described
Two foley's tube fixtures further include the second support being connect with second clamp head, the Clamping Center of first clamp head with
The Clamping Center of second clamp head is located in same horizontal line.
Wherein, the second foley's tube fixture further includes the second collet being slidably connected respectively with the guide rail and third
Collet, second collet are connect with the second support, and the third collet is connect with the collet by third actuator,
The distance between second collet and the third collet are adjusted will pass through the third actuator.
Wherein, the drug delivery device uses micro-injection pump.
(3) advantageous effect
Medicinal balloon coating equipment provided by the present invention, including spray booth, ultrasonic generator, drug delivery device, carrier gas
Device, clamping device and retracting device in the spray booth for sacculus to be sprayed to be clamped, the clamping device packet
The first foley's tube fixture and the second foley's tube fixture are included, the second foley's tube fixture being capable of relatively described first sacculus
Catheter clamp moves, and the first foley's tube fixture includes first support and connect with the first support for being clamped
State the first clamp head of the mandrel conduit of sacculus first end to be sprayed, the second foley's tube fixture include second support and
The second clamp head of the mandrel conduit for the sacculus second end to be sprayed to be clamped is connect with the second support；Described first
Foley's tube fixture further includes for driving first clamp head between first clamp head and second clamp head
Line rotation the first actuator and the second foley's tube fixture further include for drive second clamp head around
Between first clamp head and second clamp head line rotation and it is synchronous with the rotation of first clamp head holding
The second actuator；The carrier gas device includes gas-carrier pipeline for being connected to air source and is successively set on the carrier gas pipe
Drier, doping mechanism and the heating mechanism of road；The ultrasonic generator include ultrasonic generator and with the ultrasound
The ultrasonic nozzle of generator connection, the ultrasonic nozzle are connected with the drug delivery device and the gas-carrier pipeline, pass through respectively
The drug that the drug delivery device supplies is atomized by the ultrasonic wave that the ultrasonic generator generates, and is sprayed by gas-carrier pipeline
Onto the sacculus to be sprayed；The retracting device is connect with the spray booth, for spraying indoor excess waste by described
It is recycled.The medicinal balloon coating equipment can be by the medical liquid atomizing that ultrasonic generator supplies drug delivery device at uniform liquid
Drop, and liquid mist is sprayed on foley's tube by carrier gas and obtains crystallizing tiny, uniform, firm medication coat, to improve medicine
The quality of object coating, and work efficiency is high.
Description of the drawings
Fig. 1 is the structural schematic diagram according to an a kind of preferred embodiment of medicinal balloon coating equipment of the present invention.
Fig. 2 is the leftschematic diagram of the medicinal balloon coating equipment in Fig. 1；
Fig. 3 is the structural schematic diagram of the clamping device of the medicinal balloon coating equipment in Fig. 1；
Fig. 4 is the portions the A enlarged diagram of the medicinal balloon coating equipment in Fig. 3；
Fig. 5 is the structural schematic diagram of the retracting device of the medicinal balloon coating equipment in Fig. 1；
Fig. 6 is the logical schematic of the medicinal balloon coating equipment in Fig. 1.
In figure, 1：First foley's tube fixture；1-1：Coil pipe clamp head；1-1-1：First backing board；1-1-2：On second
Cover board；1-1-3 arc grooves；1-1-4 snak links；1-2：Straight tube clamp head；1-2-1：Second backing board；1-2-2：Second upper cover
Plate；1-2-3：Linear groove；1-2-4：Thread；1-3：First support；1-4：First actuator；1-5：First collet；1-6：
Clamping piece；2：Second foley's tube fixture；2-1：Second clamp head；2-2:Second support；2-3：Second actuator；2-4：Second
Collet；2-5：Third collet；3：Sacculus to be sprayed；3-1：First end mandrel conduit；3-1-1：Ring duct portion；3-1-2：It is linear
Conduit part；3-2：Second end mandrel conduit；3-3：Air inlet terminal；4：Guide rail；5：Third actuator；6：Lockable mechanism；7：Ultrasound
Generating means；8：Drug delivery device；9：Carrier gas device；9-1：Drier；9-2：Adulterate mechanism；9-3：Heating mechanism；10：Three axis
Motion；11：Retracting device；11-1：Tail gas recycle unit；11-1-1：Spray booth air inlet；11-1-2：Spray booth outlet air
Mouthful；11-1-3：Spray booth exhaust outlet；11-2：Tailing recovery unit；11-2-1：Recovering tray；11-2-2：Rewinding room；11-2-3：
Exhaust air box；11-2-4：Rewinding cup；11-2-5：Exhaust duct；11-2-6：Wind turbine；11-2-7：Feed opening；11-2-8：Ventilation hole；
11-2-9：Collet.
Specific implementation mode
With reference to the accompanying drawings and examples, the specific implementation mode of the present invention is described in further detail.Following instance
For illustrating the present invention, but it is not limited to the scope of the present invention.
In the description of the present invention, it is to be understood that, term "center", " longitudinal direction ", " transverse direction ", " length ", " width ",
" thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside", " up time
The orientation or positional relationship of the instructions such as needle ", " counterclockwise ", " axial direction ", " radial direction ", " circumferential direction " be orientation based on ... shown in the drawings or
Position relationship is merely for convenience of description of the present invention and simplification of the description, and does not indicate or imply the indicated device or element must
There must be specific orientation, with specific azimuth configuration and operation, therefore be not considered as limiting the invention.
In addition, term " first ", " second " are used for description purposes only, it is not understood to indicate or imply relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include at least one this feature.In the description of the present invention, the meaning of " plurality " is at least two, such as two, three
It is a etc., unless otherwise specifically defined.
In the present invention unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " fixation " etc.
Term shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integral；Can be that machinery connects
It connects, can also be to be electrically connected or can communicate each other；It can be directly connected, can also indirectly connected through an intermediary, it can be with
It is the interaction relationship of the connection or two elements inside two elements, unless otherwise restricted clearly.For this field
For those of ordinary skill, the specific meanings of the above terms in the present invention can be understood according to specific conditions.
Fig. 1 to Fig. 6 shows an a kind of preferred embodiment of medicinal balloon coating equipment according to the present invention.As schemed
Show, which includes spray booth, ultrasonic generator 7, drug delivery device 8, carrier gas device 9, is located at spray booth
Interior clamping device and retracting device for sacculus 3 to be sprayed to be clamped.Wherein, ultrasonic generator 7 includes ultrasonic generator
And the ultrasonic nozzle being connect with the ultrasonic generator, wherein ultrasonic nozzle after medical liquid atomizing that drug delivery device 8 supplies and will lead to
It crosses carrier gas device 9 and is sprayed onto 3 surface of sacculus formation medication coat.Wherein ultrasonic nozzle can be selected according to the specification of sacculus 3 to be sprayed
The nozzle of spray patterns such as gather or spread.Ultrasonic nozzle is connect by three-axis moving mechanism 10 with spray booth, so as to be painted
Being moved around with upper and lower three directions for sacculus 3 is applied, comprehensive spraying is carried out to sacculus 3 to be sprayed to realize；Recycling
Device 11 is connect with spray booth, is recycled for that will spray indoor excess waste.Medicinal balloon coating according to the invention
Equipment, can be by the medical liquid atomizing that ultrasonic generator supplies drug delivery device at symmetrical liquid drop, then by carrier gas by liquid mist
It sprays on sacculus 3 to obtain crystallizing tiny, uniform, firm medication coat.The device can be realized with mandrel conduit
The automatic coating of complete sacculus, obtains crystallizing tiny, uniform, firm medication coat, while improving medication coat and preparing speed.
Wherein, clamping device includes the first foley's tube fixture 1 and the second foley's tube fixture 2, the second foley's tube folder
Tool 2 can be moved with respect to the first foley's tube fixture 1.First foley's tube fixture 1 include first support 1-3 and with first
First clamp head of the frame 1-3 connections for 3 first end mandrel conduit 3-1 of sacculus to be sprayed to be clamped, the second foley's tube fixture 2 packet
It includes second support 2-2 and connect of the second end mandrel conduit 3-2 for sacculus 3 to be sprayed to be clamped with second support 2-2
Two clamp heads.First foley's tube fixture 1 further include for drive the first clamp head around the first clamp head and the second clamp head it
Between line rotation the first actuator 1-4 and the second foley's tube fixture 2 further include for driving the second clamp head around the
Line rotation between one clamp head and the second clamp head and the second actuator 2- synchronous with the rotation holding of the first clamp head
3.It is preferred that the Clamping Center of the second clamp head 2-1 and the Clamping Center of the first clamp head are located in same horizontal line.
In this embodiment, the first foley's tube fixture 1 further includes the first collet 1-5 being connect with first support 1-3, should
First collet 1-5 is fixed on spray booth bottom surface, and the second foley's tube fixture 2 is slided with the guide rail 4 being arranged on spray booth bottom surface
Dynamic connection is so that 1 relative motion of the second foley's tube fixture 2 and the first foley's tube fixture, clamping device further includes for driving
The third actuator 5 that dynamic second foley's tube fixture 2 moves on guide rail 4, and for the second foley's tube fixture 2 is opposite
Guide rail 4 keeps the lockable mechanism 6 of locking.Specifically, the second foley's tube fixture 2 includes second connect with second support 2-2
Collet 2-4, the second collet 2-4 are slidably connected with guide rail 4, in addition, the second foley's tube fixture 2 further includes third collet 2-
5, third collet 2-5 are located at the one end of the second collet 2-4 far from the first collet 1-5, and the second collet 2-4 and third collet 2-
5 by 2 third actuators for being located at 4 both sides of guide rail (such as in this embodiment use cylinder), 5 connection, to pass through the
Three actuators 5 realize 1 He of the first foley's tube fixture in turn to adjust the distance between the second collet 2-4 and third collet 2-5
The distance between second foley's tube fixture 2 is adjusted.Wherein, lockable mechanism 6 is connect with third collet 2-5, so as to by third bottom
It asks 2-5 opposite rails 4 to keep locked, and then 2 opposite rail 4 of the second foley's tube fixture is kept locked.
For the ease of operation, usually first end mandrel conduit 3-1 is folded, therefore herein by first end mandrel conduit 3-
1 is divided into ring duct portion 3-1-1 and linear conduit part 3-1-2, and the wherein diameter of ring duct portion 3-1-1 is less than the first clamp head
Clamping Center to guide rail 4 distance, with ensure the first foley's tube fixture 1 the first clamp head smooth rotation.Correspondingly,
First clamp head includes the coil pipe clamp head 1-1 and straight tube clamp head 1-2 being connect with coil pipe clamp head 1-1, straight tube clamp head
1-2 is located between coil pipe clamp head 1-1 and the second clamp head 2-1, and coil pipe clamp head 1-1 is used to accommodate ring duct portion 3-1-1,
Straight tube clamp head 1-2 is for being clamped linear conduit part 3-1-2.
Specifically, coil pipe clamp head 1-1 includes the first backing board 1-1-1 and the side with first backing board 1-1-1
The arc being provided on the first hinged upper cover plate 1-1-2, the first backing board 1-1-1 for placing ring duct portion 3-1-1 is recessed
It is locked by snak link 1-1-4 and the first upper cover plate 1-1-2 side slot 1-1-3, the first backing board 1-1-1 opposite with hinged side
Tightly, ring duct portion 3-1-1 is not compressed when the first upper cover plate 1-1-2 fastenings, that is to say, that ring duct portion 3-1-1
It is to loosen in coil pipe clamp head 1-1.It is preferred that backing board 1-1-1 is the soft plastic materials such as polytetrafluoro, polyether-ether-ketone, or to apply
The metal material for covering teflon coatings is made, and mandrel conduit is by frictionally damage when preventing from placing.
Straight tube clamp head 1-2 includes the second backing board 1-2-1 and the second upper cover plate 1- hinged with the second backing board 1-2-1
2-2, the second backing board 1-2-1 and the second upper cover plate 1-2-2 are respectively arranged with linear groove 1-2-3, as the second backing board 1-2-1
When being fastened with the second upper cover plate 1-2-2, on the linear grooves 1-2-3 and the second upper cover plate 1-2-2 on the second backing board 1-2-1
Linear grooves 1-2-3 is enclosed the slot for placing linear conduit part 3-1-2, the side of the second upper cover plate 1-2-2 and the
Two backing board 1-2-1 are hinged, and side opposite with hinged end the second upper cover plate 1-2-2 passes through thread 1-2-4 and the second collet
Plate 1-2-1 is closed and locked, and can be compressed to linear conduit part 3-1-2 when locking.It is preferred that the line on the second backing board 1-2-1
Elasticity layer (such as silica gel plate) is respectively set in linear grooves 1-2-3 on property groove 1-2-3 and the second upper cover plate 1-2-2,
To prevent the when of compressing from causing to damage to linear conduit part 3-1-2.
Sacculus 3 to be sprayed further includes the air inlet terminal 3-3 being connect with the first end mandrel conduit 3-1 of sacculus 3 to be sprayed, with
The air inlet terminal 3-3 is will pass through to inflate sacculus 3 to be sprayed.Correspondingly, the first foley's tube fixture 1 further includes for this to be clamped
The clamping piece 1-6 of air inlet terminal 3-4.
Second clamp head 2-1 uses scroll chuck structure, and the second end mandrel conduit 3-2 of medicine ball capsule 3 to be coated is placed on
In the centre bore of the scroll chuck structure, treats the second end mandrel conduit 3-2 of coating sacculus 3 by screwing and be clamped.
Carrier gas device 9 includes gas-carrier pipeline for being connect with air source and the drying machine being successively set in gas-carrier pipeline
Structure 9-1, doping mechanism 9-2 and heating mechanism 9-3.When work, carrier gas initially enters drier, and drying is housed in drier
Agent reduces carrier gas humidity, is precipitated from liquid to accelerate to spray drug for removing the vapor in carrier gas.Carrier gas is from dry
Dry mechanism 9-1 enters doping mechanism 9-2 after going out, adulterate in mechanism 9-2 equipped with the solvent for not readily dissolving sprayed object, be used for
Solvent vapo(u)r is adulterated in carrier gas to further speed up the precipitation of spraying drug.Carrier gas finally enters heating mechanism 9-3, to carrier gas
Heated, to further increase the speed of separating out of spraying drug.The carrier gas device passes through setting while drier
9-1, doping mechanism 9-2 and heating mechanism 9-3 realize the deposition rate of medication coat to carrier gas temperature, humidity and property adjustments
Adjusting, improve medication coat quality and speed of production.In addition, the carrier gas device 9 further includes the tune being arranged in gas-carrier pipeline
Pressure valve, for adjusting the pressure in gas-carrier pipeline.
Drug delivery device 8 uses micro-injection pump, such as surpasses disclosed in the CN201320326608.4 of the applicant under one's name
Sound wave dispersion injection pump, the described patent are incorporated herein in a manner of being cited in full text.
In addition, the medicinal balloon coating equipment further includes the air charging system for being inflated to sacculus 3 to be sprayed, inflation dress
Set the supply air line being connect including air supply source and with air supply source, and the free end of the supply air line is provided with and is used for and inlet end
Rule check valve of sub- 3-4 connections.
Retracting device 11 includes tailing recovery unit 11-2, wherein tailing recovery unit includes recovering tray 11-2-1, rewinding
Cup 11-2-4 and rewinding room 11-2-2, wherein rewinding room 11-2-2 is located at the lower section of recovering tray 11-2-1, in recovering tray 11-2-1
On be provided with feed opening 11-2-7, rewinding cup 11-2-4 is located in rewinding room 11-2-2, and be located at recovering tray 11-2-1 feed openings
The underface of 11-2-7, so as to after the excess waste in spraying process is recycled by recovering tray 11-2-1 through by feed opening
11-2-7 is flowed into rewinding cup 11-2-4 and is recycled.
It is formed it is preferred that recovering tray 11-2-1 includes bottom surface and the side wall being connect with the periphery of the bottom surface, is closed to prevent non-return
Excess waste on 11-2-1 is flowed out from the periphery of recovering tray 11-2-1.Further, the bottom surface of recovering tray 11-2-1 use by
The funnel structure that gradual transition reduces, feed opening 11-2-7 settings are in bottom surface center, in order to which waste material is rapidly introduced into rewinding cup 11-
In 2-4.Preferred feedstock hole 11-2-7 includes that multiple apertures that are evenly distributed on form.
In addition, the row for being provided with exhaust air box 11-2-3 below rewinding room 11-2-2 and being connected to exhaust air box 11-2-3
Wind pipeline 11-2-5 is provided in the bottom of rewinding room 11-2-2 for being connected to the logical of rewinding room 11-2-2 and exhaust air box 11-2-3
Air holes 11-2-8, to pass through the solvent flashing and not collecting into the waste material dust in rewinding cup 11-2-4 in spraying process
The ventilation hole 11-2-8 of rewinding room 11-2-2 is discharged into exhaust air box 11-2-3, and is discharged by exhaust duct 11-2-5.It is preferred that the row
The air inlet of wind pipeline 11-2-5 is provided with wind turbine 11-2-6, to accelerate the discharge of solvent flashing and waste material dust etc..
Further, which further includes the collet 11-2-9 being connect with exhaust air box 11-2-3, collet 11-2-
9 are slidably connected with guide rail 4, so that retracting device to be moved to the underface of sacculus 3 to be sprayed.
In addition, retracting device 11 further includes tail gas recycle unit 11-1, tail gas recycle unit 11-1 include for confession
Air source connection spray booth air inlet 11-1-1, be located at spray booth bottom surface on spray booth air outlet 11-1-2, and with spraying
The spray booth exhaust outlet 11-1-3 of room air outlet 11-1-2 connections.Wherein, spray booth air outlet 11-1-2 is located in guide rail 4
Centre, and preferably by multiple equally distributed keyhole formations.
It is preferred that drier (not shown) is additionally provided at spray booth air inlet 11-1-1, for reducing through spray booth air inlet
11-1-1 enters the indoor air humidity of spraying.
In this embodiment, in order to simplify structure, preferably exhaust duct 11-2-5 is connect with spray booth exhaust outlet 11-1-3.
In use, the first end mandrel conduit 3-1 disks of sacculus 3 to be sprayed are circlewise put in the first foley's tube folder first
On the coil pipe clamp head 1-1 of tool 1, and the linear conduit part of first end mandrel conduit 3-1 is consolidated by straight tube clamp head 1-2
It is fixed, the retaining mechanism 6 of the third collet 2-5 in the second foley's tube fixture 2 is placed in releasing orientation later, according to ball to be sprayed
Second foley's tube fixture 2 is moved to suitable position by the catheter length of capsule 3, by the second end mandrel conduit of sacculus 3 to be sprayed
3-2 is put on the second clamp head 2-1 of the second foley's tube fixture 2, and is locked by the lockable mechanism 6 of third collet 2-5, this
When sacculus 3 to be sprayed be slightly curved, the second collet of the second foley's tube fixture 2 is made by third actuator (cylinder) 5
2-4 is moved to the direction of third collet 2-5 to stretch 3 conduit of sacculus to be sprayed；Then by the air inlet terminal of sacculus 3 to be sprayed
3-4 is connect with Rule check valve on feeder, to be inflated to sacculus 3 to be sprayed, is disconnected air supply source after being full of, Shandong
Your check valve is stayed on the air inlet terminal 3-4 of sacculus 3 to be sprayed and is carried out by the clamping piece 1-6 of the first foley's tube fixture 1
It is fixed；It is last set good for medical abortion amount, drug delivery device 8, ultrasonic generator 7 and carrier gas device 9 are opened, three-axis moving machine is passed through
Structure 10 drives the ultrasonic nozzle of ultrasonic generator 7 to carry out spraying drug along the axial direction reciprocating motion of sacculus 3 to be sprayed,
The first actuator 1-4 and the second actuator 2-3 drives the first clamp head is synchronous with the second clamp head 2-1 to turn respectively in spraying process
It is dynamic, to realize that the comprehensive spraying to sacculus 3 to be sprayed, the residual waste not being sprayed on sacculus fall into retracting device 11
In tailing recovery unit 11-2, the solvent etc. of volatilization is inhaled into tail gas recycle unit 11-1 and is discharged.
Medicinal balloon coating equipment according to the invention, can by ultrasonic generator by medical liquid atomizing at symmetrical liquid drop,
And sprayed on foley's tube by treated the carrier gas such as preheating and dry by liquid mist obtain crystallizing it is tiny, uniform, firm
Medication coat.Simultaneously by carrier gas temperature, humidity and property adjustments, realizing the adjusting of the deposition rate of medication coat, improve
Medication coat quality and speed of production.In addition, the structure provided according to technical solution of the present invention is, it can be achieved that carry mandrel conduit
The on-line automatic spraying of complete foley's tube adapts to length from 10mm to 500mm, diameter from 1mm to 20mm, guidewire length 5m with
The foley's tube of interior various specifications does not destroy mandrel catheter surface.
The above is merely preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (13)
1. a kind of medicinal balloon coating equipment, including spray booth, ultrasonic generator, drug delivery device, carrier gas device, be located at it is described
Clamping device and retracting device in spray booth for sacculus to be sprayed to be clamped, which is characterized in that
The clamping device includes the first foley's tube fixture and the second foley's tube fixture, the second foley's tube fixture energy
Enough relatively described first foley's tube clamp movements, the first foley's tube fixture include first support and with described first
First clamp head of mandrel conduit of the holder connection for the sacculus first end to be sprayed to be clamped, the second foley's tube folder
Tool includes second support and connect the mandrel conduit for the sacculus second end to be sprayed to be clamped with the second support
Second clamp head；The first foley's tube fixture further include for driving first clamp head around first clamp head and
The first actuator and the second foley's tube fixture of line rotation between second clamp head further include for driving
Line of second clamp head between first clamp head and second clamp head is moved to rotate and press from both sides with described first
The rotation for having head keeps the second synchronous actuator；
The carrier gas device includes gas-carrier pipeline for being connected to air source and is successively set on dry in the gas-carrier pipeline
Dry mechanism, doping mechanism and heating mechanism；
The ultrasonic generator includes ultrasonic generator and the ultrasonic nozzle that is connect with the ultrasonic generator, the ultrasound spray
Head is connected with the drug delivery device and the gas-carrier pipeline respectively, will be described by the ultrasonic wave that the ultrasonic generator generates
The drug of drug delivery device supply is atomized, and is ejected on the sacculus to be sprayed by gas-carrier pipeline；
The retracting device is connect with the spray booth, for recycling the indoor excess waste of spraying.
2. medicinal balloon coating equipment according to claim 1, which is characterized in that further include guide rail, first sacculus
Catheter clamp is fixed, and the second foley's tube fixture is led by being slidably connected with the guide rail with first sacculus
Pipe clamp relative motion, the second foley's tube fixture further include for leading the second foley's tube fixture is relatively described
Rail keeps locked lockable mechanism.
3. medicinal balloon coating equipment according to claim 2, which is characterized in that the core of the sacculus first end to be sprayed
Shaft conduit includes ring duct portion and linear conduit part, and first clamp head includes coil pipe clamp head and pressed from both sides with the coil pipe
Has the straight tube clamp head of head connection, the straight tube clamp head is between the coil pipe clamp head and second clamp head, institute
Coil pipe clamp head is stated for accommodating the ring duct portion, the straight tube clamp head is for being clamped the linear conduit part.
4. medicinal balloon coating equipment according to claim 3, which is characterized in that the coil pipe clamp head includes the first bottom
Supporting plate and first upper cover plate hinged with the side of first backing board are provided on first backing board described for placing
The arc groove in ring duct portion, first backing board side opposite with hinged side pass through spring with first upper cover plate
Button connection.
5. medicinal balloon coating equipment according to claim 4, which is characterized in that the backing board uses soft plastic material
Or the metal material coated with teflon coatings is made.
6. medicinal balloon coating equipment according to claim 3, which is characterized in that the straight tube clamp head includes the second bottom
Supporting plate and second upper cover plate hinged with second backing board are provided on second backing board described linear for placing
The linear groove of conduit part, second backing board side opposite with hinged side are connected with second upper cover plate by thread
It connects.
7. medicinal balloon coating equipment according to claim 6, which is characterized in that setting is flexible in the linear groove
Layer.
8. medicinal balloon coating equipment according to claim 3, which is characterized in that the first foley's tube fixture also wraps
Include the clamping piece of the air inlet terminal for the sacculus to be sprayed to be clamped.
9. medicinal balloon coating equipment according to claim 8, which is characterized in that further include for the ball to be sprayed
The air charging system of capsule inflation, the air charging system include air supply source and the supply air line that is connect with the air supply source, and described
The free end of supply air line is provided with Rule check valve for being connect with the air inlet terminal.
10. medicinal balloon coating equipment according to claim 2, which is characterized in that second clamp head uses three-jaw
Chuck structure.
11. medicinal balloon coating equipment according to claim 2, which is characterized in that the first foley's tube fixture is also
Include the first support being connect with first clamp head, the second foley's tube fixture further includes and second clamp head
The second support of connection, the Clamping Center of first clamp head and the Clamping Center of second clamp head are located at same level
On line.
12. medicinal balloon coating equipment according to claim 2, which is characterized in that the second foley's tube fixture is also
Including the second collet being slidably connected respectively with the guide rail and third collet, second collet connects with the second support
It connects, the third collet is connect with the collet by third actuator, and described the is adjusted will pass through the third actuator
The distance between two collets and the third collet.
13. the medicinal balloon coating equipment according to any one of claim 1-12, which is characterized in that the drug delivery device
Using micro-injection pump.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810155365.XA CN108295361B (en) | 2018-02-23 | 2018-02-23 | Medicine sacculus scribbles medicine equipment |
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| CN201810155365.XA CN108295361B (en) | 2018-02-23 | 2018-02-23 | Medicine sacculus scribbles medicine equipment |
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| CN108295361A true CN108295361A (en) | 2018-07-20 |
| CN108295361B CN108295361B (en) | 2023-10-03 |
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| CN201810155365.XA Active CN108295361B (en) | 2018-02-23 | 2018-02-23 | Medicine sacculus scribbles medicine equipment |
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Cited By (7)
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| CN109248371A (en) * | 2018-09-20 | 2019-01-22 | 郑州嘉豫医疗器械有限公司 | A kind of novel sacculus molding equipment |
| CN109571327A (en) * | 2019-01-22 | 2019-04-05 | 江苏集萃微纳自动化系统与装备技术研究所有限公司 | Quick clamping device and quick-clamping method for the processing of elongated flexible workpiece rotation |
| CN114053559A (en) * | 2021-10-25 | 2022-02-18 | 北京东方金荣超声电器有限公司 | Multi-balloon clamp and batch medicine balloon medicine coating equipment |
| CN115054809A (en) * | 2022-07-11 | 2022-09-16 | 惠州市顺美医疗科技有限公司 | Medical balloon and preparation process thereof |
| CN115445057A (en) * | 2022-09-05 | 2022-12-09 | 谱创医疗科技(上海)有限公司 | Drug delivery catheter capable of improving drug absorption effect |
| CN115581848A (en) * | 2022-10-17 | 2023-01-10 | 上海申淇医疗科技有限公司 | Preparation method of medicine balloon |
| CN118121820A (en) * | 2024-05-08 | 2024-06-04 | 江苏天协医疗器械有限公司 | Balloon catheter rotating device |
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