CN115444805B - Stem cell facial cosmetic composition and application thereof - Google Patents
Stem cell facial cosmetic composition and application thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses a facial beauty composition of stem cells, which comprises 5-10 parts of stem cell composition, 0.3-0.8 part of hyaluronic acid, 0.3-0.8 part of nicotinamide, 0.5-0.9 part of collagen, 2-4 parts of glycerol and 4-10 parts of platelet-rich plasma, wherein the stem cell composition comprises umbilical mesenchymal stem cells, autologous adipose mesenchymal stem cells and mesenchymal stem cell exosomes, and the volume ratio of the umbilical mesenchymal stem cells, autologous adipose mesenchymal stem cells and mesenchymal stem cell exosomes is 1:2: (3-5). The invention relates to the technical field of cosmetic compositions, and particularly provides a stem cell facial cosmetic composition which can effectively repair epidermal cells and promote epidermal cell regeneration, has the effects of resisting wrinkles, whitening and moisturizing, and is good in repair effect and long in maintenance time, and application of the stem cell facial cosmetic composition.
Description
Technical Field
The invention relates to the technical field of cosmetic compositions, in particular to a stem cell facial cosmetic composition and application thereof.
Face rejuvenation refers to various means and methods that enable an aged face to regain its appearance. Facial aging, the result of common changes in body and soft and hard tissues of the face/neck, is mainly manifested by: the facial skin is thin and dry, skin elasticity is weakened, skin pigmentation is uneven, skin color is dark and uneven, wrinkles are increased, subcutaneous adipose tissue is reduced or locally accumulated, and sagging and muscle atrophy caused by support structure relaxation are realized. Facial aging is closely related to factors such as constitution, genetic factors, living environment, psychological emotion, working environment, nutritional status, diseases, and local skin care.
At present, the combined injection of autologous fat and PRP to the face to rejuvenate the face is a widely used cosmetic means. However, the repair effect is limited and the maintenance time is short due to self-absorption of the autologous fat. The existing facial cosmetic composition has single function and cannot simultaneously have the effects of repairing skin and maintaining skin for a long time.
Disclosure of Invention
Aiming at the situation, in order to make up the existing defects, the invention provides the stem cell facial cosmetic composition which can effectively repair the epidermal cells and promote the regeneration of the epidermal cells, has the effects of resisting wrinkle, whitening and moisturizing, and has good repair effect and long maintenance time, and the application thereof.
The invention provides the following technical scheme: the invention provides a facial beauty composition of stem cells, which comprises 5-10 parts of stem cell composition, 0.3-0.8 part of hyaluronic acid, 0.3-0.8 part of nicotinamide, 0.5-0.9 part of collagen, 2-4 parts of glycerol and 4-10 parts of platelet-rich plasma, wherein the stem cell composition comprises umbilical mesenchymal stem cells, autologous adipose mesenchymal stem cells and mesenchymal stem cell exosomes, and the volume ratio of the umbilical mesenchymal stem cells, autologous adipose mesenchymal stem cells and mesenchymal stem cell exosomes is 1:2: (3-5).
Preferably, the facial cosmetic composition of the stem cells comprises 7-8 parts of the facial cosmetic composition of the stem cells, 0.5-0.6 part of hyaluronic acid, 0.5-0.6 part of nicotinamide, 0.6-0.8 part of collagen, 2.5-3.5 parts of glycerol and 6-8 parts of platelet-rich plasma.
Preferably, a facial cosmetic composition of stem cells comprises 7.5 parts of stem cell composition, 0.55 parts of hyaluronic acid, 0.55 parts of nicotinamide, 0.7 parts of collagen, 3 parts of glycerol and 7 parts of platelet rich plasma.
As a preferred embodiment, the umbilical cord mesenchymal stem cells have a cell density of 6×10 5 ～3×10 6 And each mL.
Further, the umbilical cord mesenchymal stem cells are separated by adopting an immunomagnetic bead method based on an immunoadsorption principle.
The invention relates to an application of a stem cell facial cosmetic composition, which is an application of the stem cell facial cosmetic composition in a facial cosmetic direction, and the specific application method comprises the following steps: the stem cell facial cosmetic composition is injected on the face of a person to be beautified in a punctiform manner, wherein the punctiform injection interval is 4-5 mm, and the injection layer is the dermis layer.
The beneficial effects obtained by the invention by adopting the structure are as follows: the facial cosmetic composition of stem cells and the application thereof provided by the invention have the advantages that umbilical mesenchymal stem cells proliferate under the regulation of organisms and secrete a large amount of active factors to improve skin, adipose tissue can be differentiated to form facial fine lines, the self-extracted absorption of the stem cells is improved through the autologous adipose mesenchymal stem cells, meanwhile, the moisture content of the skin can be rapidly improved through hyaluronic acid and collagen, the skin is maintained to be moist and smooth, fine, smooth, tender and elastic, and the facial cosmetic composition has the functions of crease resistance, wrinkle resistance, beauty and health care and skin physiological function recovery; the niacinamide assists in maintaining skin moisture, repairing skin barrier, reducing water loss, and utilizing glycerol to play a role in moisturizing skin, and meanwhile, the glycerol can be used as a solvent, so that the relative components are dispersed; the components are reasonable in compatibility and synergistic, can effectively repair epidermal cells and promote epidermal cell regeneration, and has the effects of resisting wrinkles, whitening and moisturizing, and has the technical effects of good repair effect and long maintenance time.
Detailed Description
The technical solutions of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments; all other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
(1) Preparation of umbilical cord mesenchymal stem cells: collecting umbilical blood, collecting umbilical blood by medical staff with professional qualification by using a sealed blood bag containing anticoagulant, separating umbilical blood mononuclear cells by using a density gradient centrifugation method, specifically marking, passing the umbilical blood mononuclear cells through a separation column placed in a strong and stable magnetic field after magnetic marking, and separating hematopoietic stem cells from the mononuclear cells by adopting an immunomagnetic bead method;
(2) Preparation of autologous adipose-derived mesenchymal stem cells: extracting fat and lower abdominal fat on the inner side of the thigh of a cosmetologist, centrifuging the fat for 500G and 4 minutes after removing bloody swelling liquid on the lower layer, obtaining middle-layer pure fat after centrifugation, adding 0.1% collagenase solution according to the volume ratio of 1:1, fully and uniformly mixing, putting into a shaking table at 37 ℃ for shaking and digestion for 40 minutes at 200rpm, putting into 800G and centrifuging for 5 minutes after digestion is finished, removing fat and solution after upper-layer digestion, obtaining stem cell sediment at the bottom, then respectively adding serum of the cosmetologist according to the ratio of 1:2, fully and uniformly mixing, adding normal saline to 40ml, centrifuging for 300G and 3 minutes, removing upper-layer solution after centrifugation, adding normal saline to 40ml for 300G and 3 minutes again, centrifuging for 3 times, and filtering the obtained sediment through a 100 mu m filter to obtain about 4ml of filtrate;
(3) Preparation of mesenchymal stem cell exosomes: separating exosomes from umbilical cord mesenchymal stem cells and autologous adipose mesenchymal stem cells for later use;
(4) Umbilical cord mesenchymal stem cells, autologous adipose mesenchymal stem cells and mesenchymal stem cell exosomes were prepared according to 1:2: mixing the components (3-5) in a volume ratio;
(5) 7.5 parts of stem cell composition, 0.55 part of hyaluronic acid, 0.55 part of nicotinamide, 0.7 part of collagen, 3 parts of glycerol and 7 parts of platelet-rich plasma are uniformly mixed to obtain the required stem cell facial cosmetic composition, and then the stem cell facial cosmetic composition is injected into the face of a cosmetology person in a punctiform manner through an injector, wherein the punctiform injection interval is 4-5 mm, and the injection layer is a dermis layer.
Example 2
(1) Preparation of umbilical cord mesenchymal stem cells: collecting umbilical blood, collecting umbilical blood by medical staff with professional qualification by using a sealed blood bag containing anticoagulant, separating umbilical blood mononuclear cells by using a density gradient centrifugation method, specifically marking, passing the umbilical blood mononuclear cells through a separation column placed in a strong and stable magnetic field after magnetic marking, and separating hematopoietic stem cells from the mononuclear cells by adopting an immunomagnetic bead method;
(2) Preparation of autologous adipose-derived mesenchymal stem cells: extracting fat and lower abdominal fat on the inner side of the thigh of a cosmetologist, centrifuging the fat for 500G and 4 minutes after removing bloody swelling liquid on the lower layer, obtaining middle-layer pure fat after centrifugation, adding 0.1% collagenase solution according to the volume ratio of 1:1, fully and uniformly mixing, putting into a shaking table at 37 ℃ for shaking and digestion for 40 minutes at 200rpm, putting into 800G and centrifuging for 5 minutes after digestion is finished, removing fat and solution after upper-layer digestion, obtaining stem cell sediment at the bottom, then respectively adding serum of the cosmetologist according to the ratio of 1:2, fully and uniformly mixing, adding normal saline to 40ml, centrifuging for 300G and 3 minutes, removing upper-layer solution after centrifugation, adding normal saline to 40ml for 300G and 3 minutes again, centrifuging for 3 times, and filtering the obtained sediment through a 100 mu m filter to obtain about 4ml of filtrate;
(3) Preparation of mesenchymal stem cell exosomes: separating exosomes from umbilical cord mesenchymal stem cells and autologous adipose mesenchymal stem cells for later use;
(4) Umbilical cord mesenchymal stem cells, autologous adipose mesenchymal stem cells and mesenchymal stem cell exosomes were prepared according to 1:2: mixing the components (3-5) in a volume ratio;
(5) 5 parts of stem cell composition, 0.3 part of hyaluronic acid, 0.3 part of nicotinamide, 0.5 part of collagen, 2 parts of glycerol and 4 parts of platelet-rich plasma are uniformly mixed to obtain the required stem cell facial cosmetic composition, and then the stem cell facial cosmetic composition is injected into the face of a cosmetology person in a punctiform manner through an injector, wherein the punctiform injection interval is 4-5 mm, and the injection layer is a dermis layer.
Example 3
(1) Preparation of umbilical cord mesenchymal stem cells: collecting umbilical blood, collecting umbilical blood by medical staff with professional qualification by using a sealed blood bag containing anticoagulant, separating umbilical blood mononuclear cells by using a density gradient centrifugation method, specifically marking, passing the umbilical blood mononuclear cells through a separation column placed in a strong and stable magnetic field after magnetic marking, and separating hematopoietic stem cells from the mononuclear cells by adopting an immunomagnetic bead method;
(2) Preparation of autologous adipose-derived mesenchymal stem cells: extracting fat and lower abdominal fat on the inner side of the thigh of a cosmetologist, centrifuging the fat for 500G and 4 minutes after removing bloody swelling liquid on the lower layer, obtaining middle-layer pure fat after centrifugation, adding 0.1% collagenase solution according to the volume ratio of 1:1, fully and uniformly mixing, putting into a shaking table at 37 ℃ for shaking and digestion for 40 minutes at 200rpm, putting into 800G and centrifuging for 5 minutes after digestion is finished, removing fat and solution after upper-layer digestion, obtaining stem cell sediment at the bottom, then respectively adding serum of the cosmetologist according to the ratio of 1:2, fully and uniformly mixing, adding normal saline to 40ml, centrifuging for 300G and 3 minutes, removing upper-layer solution after centrifugation, adding normal saline to 40ml for 300G and 3 minutes again, centrifuging for 3 times, and filtering the obtained sediment through a 100 mu m filter to obtain about 4ml of filtrate;
(3) Preparation of mesenchymal stem cell exosomes: separating exosomes from umbilical cord mesenchymal stem cells and autologous adipose mesenchymal stem cells for later use;
(4) Umbilical cord mesenchymal stem cells, autologous adipose mesenchymal stem cells and mesenchymal stem cell exosomes were prepared according to 1:2: mixing the components (3-5) in a volume ratio;
(5) The method comprises the steps of uniformly mixing 10 parts of stem cell composition, 0.8 part of hyaluronic acid, 0.8 part of nicotinamide, 0.9 part of collagen, 4 parts of glycerol and 10 parts of platelet-rich plasma to obtain the required facial cosmetic composition of the stem cells, and then injecting the facial cosmetic composition of the stem cells into the face of a person to be beautified in a punctiform manner through an injector, wherein the punctiform injection interval is 4-5 mm, and the injection layer is a dermis layer.
Comparative example 1
Uniformly mixing 0.55 part of hyaluronic acid, 0.55 part of nicotinamide, 0.7 part of collagen, 3 parts of glycerol and 7 parts of platelet-rich plasma, and injecting the mixture into the face of a cosmetology person in a punctiform manner through an injector, wherein the punctiform injection interval is 4-5 mm, and the injection layer is a dermis layer.
Comparative example 2
Uniformly mixing 0.3 part of hyaluronic acid, 0.3 part of nicotinamide, 0.5 part of collagen, 2 parts of glycerol and 4 parts of platelet-rich plasma, and injecting the mixture into the face of a cosmetology person in a punctiform manner through an injector, wherein the punctiform injection interval is 4-5 mm, and the injection layer is a dermis layer.
Comparative example 3
Uniformly mixing 0.8 part of hyaluronic acid, 0.8 part of nicotinamide, 0.9 part of collagen, 4 parts of glycerol and 10 parts of platelet-rich plasma, and injecting the mixture into the face of a cosmetology person in a punctiform manner through an injector, wherein the punctiform injection interval is 4-5 mm, and the injection layer is a dermis layer.
120 subjects aged 28-40 years are selected, and are equally divided into 6 groups, and the numbers of the groups are 1-6 in sequence. The test groups numbered 1 to 3 respectively applied the stem cell cosmetic preparations of examples 1 to 3 to the face (post-face-washing application), and the test groups numbered 4 to 6 respectively applied the cosmetic preparations of comparative examples 1 to 3 to the face (post-face-washing application). Each group of subjects was continuously applied for 30 days without any other skin care product.
After 30 days, the elasticity, the moisture, the pore size and the wrinkle improvement condition of the skin of a test subject can be known, and the facial cosmetic composition with stem cells provided by the scheme can effectively improve the skin condition and can effectively repair the epidermal cells.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. The facial cosmetic composition of the stem cells is characterized by comprising 5-10 parts of the stem cell composition, 0.3-0.8 part of hyaluronic acid, 0.3-0.8 part of nicotinamide, 0.5-0.9 part of collagen, 2-4 parts of glycerol and 4-10 parts of platelet-rich plasma, wherein the stem cell composition comprises umbilical mesenchymal stem cells, autologous adipose mesenchymal stem cells and mesenchymal stem cell exosomes, and the volume ratio of the umbilical mesenchymal stem cells, autologous adipose mesenchymal stem cells and mesenchymal stem cell exosomes is 1:2: (3-5).
2. The facial cosmetic composition of stem cells according to claim 1, wherein the facial composition comprises 7-8 parts of stem cell composition, 0.5-0.6 part of hyaluronic acid, 0.5-0.6 part of nicotinamide, 0.6-0.8 part of collagen, 2.5-3.5 parts of glycerol and 6-8 parts of platelet rich plasma.
3. The facial cosmetic stem cell composition of claim 1, comprising 7.5 parts of the facial stem cell composition, 0.55 parts of hyaluronic acid, 0.55 parts of nicotinamide, 0.7 parts of collagen, 3 parts of glycerol and 7 parts of platelet rich plasma.
4. The facial cosmetic composition of stem cells according to claim 1, wherein the umbilical mesenchymal stem cells have a cell density of 6 x 10 5 ～3×10 6 And each mL.
5. The facial cosmetic composition of stem cells according to claim 1, wherein the umbilical cord mesenchymal stem cells are isolated by immunomagnetic bead method based on immunoadsorption principle.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107375189A (en) * | 2017-05-08 | 2017-11-24 | 广州资生生物科技有限公司 | A kind of stem cell composition and face rejuvenation cosmetic formulation |
| CN108578784A (en) * | 2018-02-06 | 2018-09-28 | 曲平波 | A kind of biomimetic type hydrogel stem cell composition and preparation method thereof |
| CN108853001A (en) * | 2018-09-20 | 2018-11-23 | 北京原肽干细胞医学研究院有限公司 | A kind of skin repair liquid and preparation method thereof containing stem cell extract |
| CN110368404A (en) * | 2019-07-16 | 2019-10-25 | 厦门艾赛生物科技有限公司 | A kind of gynecological gel and preparation method thereof |
| WO2020130800A1 (en) * | 2018-12-21 | 2020-06-25 | Cytonex Sdn. Bhd. | Stem cell conditioned media |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375189A (en) * | 2017-05-08 | 2017-11-24 | 广州资生生物科技有限公司 | A kind of stem cell composition and face rejuvenation cosmetic formulation |
| CN108578784A (en) * | 2018-02-06 | 2018-09-28 | 曲平波 | A kind of biomimetic type hydrogel stem cell composition and preparation method thereof |
| CN108853001A (en) * | 2018-09-20 | 2018-11-23 | 北京原肽干细胞医学研究院有限公司 | A kind of skin repair liquid and preparation method thereof containing stem cell extract |
| WO2020130800A1 (en) * | 2018-12-21 | 2020-06-25 | Cytonex Sdn. Bhd. | Stem cell conditioned media |
| CN110368404A (en) * | 2019-07-16 | 2019-10-25 | 厦门艾赛生物科技有限公司 | A kind of gynecological gel and preparation method thereof |
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