CN115429986B - Inhalation device for soft ball particle drug delivery - Google Patents

Inhalation device for soft ball particle drug delivery Download PDF

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Publication number
CN115429986B
CN115429986B CN202211026797.3A CN202211026797A CN115429986B CN 115429986 B CN115429986 B CN 115429986B CN 202211026797 A CN202211026797 A CN 202211026797A CN 115429986 B CN115429986 B CN 115429986B
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China
Prior art keywords
groove
cavity
block
wall
rotating
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CN202211026797.3A
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Chinese (zh)
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CN115429986A (en
Inventor
刘可
董杰
何捷杰
叶雨晴
史楷岐
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Suzhou Yihe Pharmaceutical Co ltd
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Suzhou Yihe Pharmaceutical Co ltd
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Priority to CN202211026797.3A priority Critical patent/CN115429986B/en
Publication of CN115429986A publication Critical patent/CN115429986A/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/10—Equipment for cleaning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0625—Mouth
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses an inhalation device for soft ball particle drug delivery, comprising: the medicine placing device is provided with a suction nozzle at the top end, a bottom cover at the bottom end, and two needling devices symmetrically arranged on the medicine placing device; through placing the medicine in putting the medicine device, press the acupuncture device for acupuncture device is trompil to the medicine, then uses the suction nozzle of design to absorb, and the granule in the medicine is through the suction nozzle suction, avoids the low, the FPF low problem of medicine delivery volume.

Description

Inhalation device for soft ball particle drug delivery
Technical Field
The present invention relates to the technical field of inhalation devices, and more particularly to an inhalation device for soft ball particle drug delivery.
Background
Oral inhalation formulations have unique advantages in the treatment of respiratory diseases such as asthma, chronic obstructive pulmonary disease, etc., such as: has the advantages of quick effect, good targeting property, small dosage, small side effect, no liver first pass effect, high bioavailability, good compliance and the like.
Oral inhalation formulations are mainly classified into three types, aerosol inhalation solutions (Nebulizer), aerosols (MDI) and dry powder inhalation formulations (DPI, also called powder inhalation). DPI is a new formulation developed on the basis of MDI, and needs to use a special inhalation device, wherein the device is filled with micronized or mixed medicines with carriers, and the medicines are inhaled along with air flow of a patient, pass through a specially designed air flow channel in the device and are dispersed into microparticles with aerodynamic particle size of 1-5 microns as much as possible to enter the lower respiratory tract of a human body, so as to exert local or systemic effect.
The aerodynamic particle size of the Active Pharmaceutical Ingredient (API) of DPI is the most important property reflecting the deposition and final therapeutic effect of the drug in the lungs. Generally, when the aerodynamic particle size of the drug is in the range of 1-5 μm, it is able to reach the peripheral airways of the most effective absorption sites of the lung; while particles larger than 5 μm are typically deposited in the mouth or throat, particles smaller than 0.5 μm are typically not deposited, continuing in brownian motion or exhaling outwardly with the human exhaling motion. Thus, the particle size distribution of the API can directly affect the amount of lung deposition. The proportion of Fine Particles (FPF), i.e. the proportion of particles smaller than 5 μm in size produced by drug release from the inhaled formulation, to all drug released, is the greater the FPF, indicating a higher atomizing efficiency of the DPI.
The powder particles (aerodynamic diameter 1-5 μm) for inhalation have natural cohesiveness, and the micronized powder tends to agglomerate, which reduces the fluidity and dispersibility of the powder itself, thereby affecting the delivery efficiency and uniformity of drug delivery when the patient uses the dry powder inhalation formulation. To address this problem, different prescription processes were created, the most common process being to adhere the API to larger carrier particles, but this approach is not suitable for prescriptions for high dose administration, as they typically only contain 0.1% -2% API. Another prescription processing process is to utilize the attachment mechanism of the API to form aggregates of micropowder particles, i.e., soft spheres, which may contain up to 100% of the API and which are sufficiently and stable for administration, with the soft spheres deagglomerating and delivery to the patient's lungs within the administration device following patient inhalation.
Drug particles of the mainstream dry powder inhalation formulations in the market are mostly prepared by a process of adhering API to larger carrier particles, and drug delivery devices matched with the drug particles are designed according to the characteristics of the drug particles. When drug particles prepared by the soft ball particle process are delivered by this type of device, problems such as low drug delivery dosage, low FPF and the like can occur. Accordingly, there is a need for an inhalation device for soft ball particle drug delivery that at least partially addresses the problems of the prior art.
Disclosure of Invention
In the summary, a series of concepts in a simplified form are introduced, which will be further described in detail in the detailed description. The summary of the invention is not intended to define the key features and essential features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter.
To at least partially solve the above problems, the present invention provides an inhalation device for soft ball particle drug delivery, comprising:
the medicine placing device is characterized in that a suction nozzle is arranged at the top end of the medicine placing device, a bottom cover is arranged at the bottom end of the medicine placing device, and two needling devices are symmetrically arranged on the medicine placing device.
Preferably, the drug delivery device comprises:
the shell is provided with a rotary groove at the top end, and a limit groove is arranged at the bottom end of the inner wall of the rotary groove;
and the two air inlets are centrally and symmetrically arranged on the side wall of the rotary groove.
Preferably, the suction nozzle includes:
the suction pipe is arranged at the top end of the cover plate, and the bottom end of the cover plate is provided with a rotating block;
the rotating groove is formed in the shell, the rotating groove is formed in one side of the rotating groove, and the rotating block is connected in the rotating groove in a rotating mode;
the clamping plate is arranged at the top end of the shell and is positioned at one side of the rotating groove;
the clamping block is arranged at the bottom end of the cover plate and is positioned at one side far away from the rotating block;
the spiral channel is arranged on the inner wall of the suction pipe;
and the grid net is arranged on the cover plate.
Preferably, the needling apparatus includes:
the pressing groove is arranged in the shell and is positioned at one side of the rotating groove;
the pressing sleeve is connected in the pressing groove in a sliding manner;
one end of the needle is arranged in the pressing sleeve through the needle seat, and the other end of the needle extends into the limit groove;
and the pressing spring is arranged between the pressing sleeve and the pressing groove.
Preferably, the bottom cover is provided with a mounting fixture block, and the mounting fixture block is clamped on the shell.
Preferably, one side of the needle far away from the needle seat is provided with three needle points.
Preferably, a filtering device is further arranged on the side wall of the air inlet channel, and the filtering device comprises:
the shielding groove is arranged on the inner wall of the air inlet channel, the shielding block is connected in a sliding manner in the shielding groove, and an air nozzle is arranged in the shielding block;
one end of the threaded pipe is communicated with the air jet port, and the threaded pipe is provided with a plurality of air nozzles; the other end of the threaded pipe extends into the shielding groove;
the fixed plate is fixedly arranged on the inner wall of the shielding groove, and the threaded pipe slides through the fixed plate;
the top end of the threaded sleeve is rotationally connected with the bottom end of the connecting sleeve, the connecting sleeve is connected with the bottom end of the fixing plate, and the threaded sleeve is sleeved on the threaded pipe through threads;
the miniature motor is arranged on the inner wall of the shielding groove, the miniature motor is connected with the gear through a first rotating rod, and the gear is meshed with the outer wall of the thread sleeve;
the filter block is arranged on one side of the shell, and an air cavity is arranged in the filter block;
one end of the corrugated pipe is connected with the threaded pipe, the other end of the corrugated pipe is connected with a first pipeline, and the other end of the first pipeline stretches into the filter block and is communicated with the inner air cavity;
the fan is arranged in the filter block and is connected with the air cavity through a second pipeline;
the heating block is sleeved on the second pipeline and is positioned between the air cavity and the fan;
the rotary cylinder, one end of the rotary cylinder stretches into the air cavity to be fixedly connected with the spray ball, the other end of the rotary cylinder is rotationally connected with the second pipeline, a plurality of rotary blades are uniformly arranged on the inner wall of the rotary cylinder, and the rotary blades are obliquely arranged around the circle center of the rotary cylinder to the clockwise direction;
the spraying ball comprises a spraying ball body, a spraying cavity, a plurality of spraying holes and a plurality of spraying nozzles, wherein the spraying cavity is arranged in the spraying ball body, the inner wall of the spraying cavity is uniformly provided with the plurality of spraying holes, and the spraying holes are obliquely arranged in the anticlockwise direction around the circle center of the spraying cavity.
Preferably, an injection device is further disposed in the filter block, and the injection device includes:
the transmission cavity is arranged in the filter block, the transmission cavity is positioned between the air cavity and the fan, and the rotating cylinder penetrates through the transmission cavity;
the liquid storage cavity is arranged in the filter block, and the liquid storage cavity is connected with the air cavity through a third pipeline;
the first driving wheel is sleeved on the rotating cylinder and is positioned in the driving cavity;
one end of the second rotating rod is rotationally connected with the inner wall of the transmission cavity, and the other end of the second rotating rod extends into the third pipeline to be connected with a water control gear;
the second driving wheel is sleeved on the second rotating rod and positioned in the driving cavity, and the second driving wheel is in driving connection with the first driving wheel through a belt;
the sliding plate is connected in the liquid storage cavity in a sliding mode, and an extrusion spring is arranged between the sliding plate and the inner wall of the liquid storage cavity.
Preferably, the suction nozzle is sleeved with a dust cover.
Preferably, the outer wall of the pressing sleeve is provided with anti-skid patterns.
Compared with the prior art, the invention at least comprises the following beneficial effects:
according to the inhalation device for soft ball particle drug delivery, the drug is placed in the drug placement device, the needling device is pressed, so that the needling device is used for perforating the drug, then a designed suction nozzle is used for sucking the drug, particles in the drug are sucked out through the suction nozzle, and the problems of low drug delivery quantity and low FPF are avoided.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Drawings
The accompanying drawings are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate the invention and together with the embodiments of the invention, serve to explain the invention. In the drawings:
FIG. 1 is an exploded schematic view of an inhalation device for soft ball particle drug delivery according to the present invention;
FIG. 2 is a schematic diagram of the structure of a mouthpiece of an inhalation device for soft ball particle drug delivery according to the present invention;
FIG. 3 is a schematic structural view of a housing of an inhalation device for soft ball particle drug delivery according to the present invention;
FIG. 4 is a schematic diagram of the structure of a filter device of an inhalation device for soft ball particle drug delivery according to the present invention;
FIG. 5 is a schematic view of the structure of a filter block of an inhalation device for soft ball particle drug delivery according to the present invention;
fig. 6 is a schematic diagram of the structure of a spray ball of an inhalation device for soft ball particle drug delivery according to the present invention.
Reference numerals illustrate: 1. a suction nozzle; 2. a drug placement device; 3. a bottom cover; 4. a needling device; 5. a suction pipe; 6. a cover plate; 7. a rotating block; 8. a clamping block; 9. a spiral channel; 10. a housing; 11. a rotating groove; 12. a rotary groove; 13. a limit groove; 14. an air inlet pipe; 15. a clamping plate; 17. a pressing groove; 18. pressing the sleeve; 19. a needle stand; 20. a needle; 21. pressing the spring; 22. installing a clamping block; 23. a grid mesh; 24. a filtering device; 25. a shielding groove; 26. a shielding block; 27. a gas injection hole; 28. a threaded tube; 29. a fixing plate; 30. connecting sleeves; 31. a thread sleeve; 32. a micro motor; 33. a first rotating lever; 34. a gear; 35. a bellows; 36. a first pipe; 37. a filter block; 38. an air cavity; 39. spraying balls; 40. a rotating cylinder; 41. a heating block; 42. a second pipe; 43. a blower; 44. a discharge chamber; 45. a discharge hole; 46. rotating the blade; 47. a first driving wheel; 48. a belt; 49. a second driving wheel; 50. a second rotating lever; 51. a water control gear; 52. a third conduit; 53. a liquid storage cavity; 54. a sliding plate; 55. extruding a spring; 56. a transmission cavity.
Detailed Description
The present invention is described in further detail below with reference to the drawings and examples to enable those skilled in the art to practice the invention by referring to the description.
It will be understood that terms, such as "having," "including," and "comprising," as used herein, do not preclude the presence or addition of one or more other elements or groups thereof.
As shown in fig. 1-6, the present invention provides an inhalation device for soft ball particle drug delivery, comprising:
the medicine placement device 2, medicine placement device 2 top is equipped with suction nozzle 1, medicine placement device 2 bottom is equipped with bottom 3, the symmetry is equipped with two acupuncture devices 4 on the medicine placement device 2.
The technical scheme has the working principle and beneficial effects that: in the in-service use process, through placing the medicine in put medicine device 2, press acupuncture device 4 for acupuncture device 4 is trompil to the medicine, then uses through design suction nozzle 1 to absorb, and the granule in the medicine is through suction nozzle 1 suction, avoids the low, the FPF low problem of medicine delivery volume.
In one embodiment, the drug delivery device 2 comprises:
the shell 10, the top of the shell 10 is provided with a rotary groove 12, and the bottom of the inner wall of the rotary groove 12 is provided with a limit groove 13;
the air inlet 14, two air inlet 14 are centrally and symmetrically arranged on the side wall of the rotary groove 12.
The technical scheme has the working principle and beneficial effects that: in the in-service use, during the use, open the suction nozzle, place the medicine in the spacing groove 13, then open the hole in the medicine through needling device 4, then cover suction nozzle 1 on rotatory groove 12, through the suction nozzle suction, the air gets into through intake duct 14 for the medicine leaves spacing groove 13 and gets into rotatory groove 12, and rotate in rotatory groove 12 under the effect of the intake duct 14 that the slant set up, spill inside powder, inhaled by the user, very big improvement the delivery volume and the FPF of medicament.
In one embodiment, the suction nozzle 1 comprises:
the suction pipe 5 is arranged at the top end of the cover plate 6, and a rotating block 7 is arranged at the bottom end of the cover plate 6;
a rotating groove 11, wherein the rotating groove 11 is arranged on the shell 10, the rotating groove 11 is positioned at one side of the rotating groove 12, and the rotating block 7 is rotatably connected in the rotating groove 11;
the clamping plate 15 is arranged at the top end of the shell 10, and the clamping plate 15 is positioned at one side of the rotating groove 11;
the clamping block 8 is arranged at the bottom end of the cover plate 6, and the clamping block 8 is positioned at one side far away from the rotating block 7;
a spiral passage 9, the spiral passage 9 being provided on an inner wall of the suction pipe 5;
a grid mesh 23, the grid mesh 23 being provided on the cover plate 6.
The technical scheme has the working principle and beneficial effects that: in the actual use process, before the use, the cover plate 6 is rotated through the rotating block 7, so that the clamping block 8 leaves the clamping plate 15, the rotating groove 12 is opened, then medicines are put in, then the cover plate 6 is rotated, so that the clamping block 8 is clamped by the clamping plate 15 again, then the medicines are sucked through the suction pipe 5, the medicines enter the spiral channel 9 after passing through the grid net 23, then are sucked by a user through the spiral channel 9, and the fine particles in the sucked medicines are greatly increased through the grid net 23 and the spiral channel 9, so that a better effect can be achieved in the process of depositing the medicines in the lung
In one embodiment, the needling apparatus 4 comprises:
a pressing groove 17, wherein the pressing groove 17 is arranged in the shell 10, and the pressing groove 17 is positioned at one side of the rotary groove 12;
a pressing sleeve 18, wherein the pressing sleeve 18 is slidably connected in the pressing groove 17;
a needle 20, wherein one end of the needle 20 is arranged in the pressing sleeve 18 through a needle seat 19, and the other end of the needle 20 extends into the limit groove 13;
and a pressing spring 21, wherein the pressing spring 21 is arranged between the pressing sleeve 18 and the pressing groove 17.
The technical scheme has the working principle and beneficial effects that: in the actual use process, the pressing sleeve 18 is pressed, and the pressing sleeve 18 drives the needle 20 to move towards the compression direction of the pressing spring 21 through the needle seat 19, so that the needle enters the limiting groove 13 to open a hole for the medicine, and the medicine in the medicine can be sucked.
In one embodiment, the bottom cover 3 is provided with a mounting fixture block 22, and the mounting fixture block 22 is clamped on the housing 10.
The technical scheme has the working principle and beneficial effects that: the bottom cover is installed on the shell 10 through the installation fixture block 22, so that the bottom cover is convenient to detach, and the needling device 4 is convenient to overhaul.
In one embodiment, the needle 20 is provided with a three-sided tip on the side remote from the needle hub 19.
The technical scheme has the working principle and beneficial effects that: the three-sided needlepoint is arranged, and after the needle completes the perforation of the medicine, the hole caused by the three-sided needlepoint cannot be closed again.
In one embodiment, a filtering device 24 is further disposed on a side wall of the air inlet 14, and the filtering device 24 includes:
the shielding groove 25 is arranged on the inner wall of the air inlet channel 14, the shielding block 26 is connected in a sliding manner in the shielding groove 25, and an air nozzle 27 is arranged in the shielding block 26;
a threaded pipe 28, one end of the threaded pipe 28 is communicated with the air jet 27; the other end of the threaded pipe 28 extends into the shielding groove 25;
a fixing plate 29, wherein the fixing plate 29 is fixedly arranged on the inner wall of the shielding groove 25, and the threaded pipe 28 slides through the fixing plate 29;
the top end of the threaded sleeve 31 is rotatably connected with the bottom end of the connecting sleeve 30, the connecting sleeve 30 is connected with the bottom end of the fixing plate 29, and the threaded sleeve 31 is sleeved on the threaded pipe 28 through threads;
a micro motor 32, wherein the micro motor 32 is arranged on the inner wall of the shielding groove 25, the micro motor 32 is connected with the gear 34 through a first rotating rod 33, and the gear 34 is meshed with the outer wall of the thread bush 31;
a filter block 37, wherein the filter block 37 is arranged on one side of the shell 10, and an air cavity 38 is arranged in the filter block 37;
the corrugated pipe 35, one end of the corrugated pipe 35 is connected with the threaded pipe 28, the other end of the corrugated pipe 35 is connected with the first pipeline 36, and the other end of the first pipeline 36 extends into the air cavity 38 in the filter block 37 to be communicated;
a fan 43, wherein the fan 43 is arranged in the filter block 37 and is connected with the air cavity 38 through a second pipeline 42;
the heating block 41 is sleeved on the second pipeline 42, and the heating block 41 is positioned between the air cavity 38 and the fan 43;
the rotary cylinder 40, one end of the rotary cylinder 40 stretches into the air cavity 38 to be fixedly connected with the spray ball 39, the other end of the rotary cylinder 40 is rotationally connected with the second pipeline 42, a plurality of rotary blades 46 are uniformly arranged on the inner wall of the rotary cylinder 40, and the rotary blades 46 are obliquely arranged around the circle center of the rotary cylinder 40 in a clockwise direction;
the spraying cavity 44 is arranged in the spraying ball 39, a plurality of spraying holes 45 are uniformly formed in the inner wall of the spraying cavity 44, and the spraying holes 45 are obliquely arranged around the circle center of the spraying cavity 44 in the anticlockwise direction.
The technical scheme has the working principle and beneficial effects that: in the actual use process, the motor 32 is started, the motor 32 drives the gear 34 to rotate through the first rotating rod 33, the gear 34 drives the threaded sleeve 31 to rotate on the connecting pipe 30, and in the rotating process, the threaded sleeve 31 drives the threaded pipe 28 to move towards the compression direction of the corrugated pipe 35 through threads, so that the stop block 26 is driven to withdraw from the air inlet channel 14, the air inlet channel 14 enters gas, the rotating groove 12 can be closed through the stop block 26 when the inhalation device is not used, dust and sundries are prevented from entering, and the cleanliness inside the rotating groove 12 is improved; meanwhile, after the hole forming of the medicine is finished, a fan 43 and a heating block 41 can be started, the fan 43 sends air into the rotating cylinder 40 from the outside through a second pipeline 42, then the air enters the spraying ball 39 from the rotating cylinder 40, and is sprayed out through a spraying hole 45 obliquely arranged in the anticlockwise direction, in the spraying process, the air can rotate clockwise with the spraying ball 39, the spraying ball 39 drives the rotating cylinder 40 to rotate, the rotating cylinder 40 drives air flow to rotate through a rotating blade 46 arranged inside, so that dust in the air is thrown onto the inner wall of the rotating cylinder 40 through centrifugal force, the dust is filtered, and the air sprayed out from the spraying ball 39 sequentially enters the air duct 14 through the air cavity 38, the first pipeline 36, the corrugated pipe 35, the threaded pipe 28 and the air outlet 27, so that the suction device can be used in places with high dust concentration in the use process; the heating block 41 can heat the entering air, so that the cough and cold caused by the fact that a user sucks a large amount of cold air at a time in winter is avoided; meanwhile, the blower can actively blow air to the user, so that the problem that the suction force is insufficient and the medicine cannot be sucked rapidly when the inhalation device is used by the old user is avoided.
In one embodiment, an injection device is further provided in the filter block 37, and the injection device includes:
a transmission cavity 56, wherein the transmission cavity 56 is arranged in the filter block 37, the transmission cavity 56 is positioned between the air cavity 38 and the fan 43, and the rotary cylinder 40 passes through the transmission cavity 56;
the liquid storage cavity 53 is arranged in the filter block 37, and the liquid storage cavity 53 is connected with the air cavity 38 through a third pipeline 52;
a first driving wheel 47, wherein the first driving wheel 47 is sleeved on the rotating cylinder 40, and the first driving wheel 47 is positioned in the driving cavity 56;
the second rotating rod 50, one end of the second rotating rod 50 is rotatably connected with the inner wall of the transmission cavity 56, and the other end of the second rotating rod 50 extends into the third pipeline 52 and is connected with the water control gear 51;
the second driving wheel 49 is sleeved on the second rotating rod 50, the second driving wheel 49 is positioned in the driving cavity 56, and the second driving wheel 49 is in driving connection with the first driving wheel 47 through a belt 48;
the sliding plate 54, the sliding plate 54 is slidably connected in the liquid storage cavity 53, and a compression spring 55 is disposed between the sliding plate 54 and the inner wall of the liquid storage cavity 53.
The technical scheme has the working principle and beneficial effects that: in the actual use process, a certain amount of liquid or liquid medicament can be added into the liquid storage cavity 53, when the rotary cylinder 40 rotates, the rotary cylinder 40 drives the first driving wheel 47 to rotate, the first driving wheel 47 drives the second driving wheel 49 to rotate through a belt, the second driving wheel 49 drives the water control gear 51 to rotate through the second rotating rod 50, in the rotation process of the water control gear 51, the liquid or liquid medicament in the liquid storage cavity 53 is sprayed into the air cavity 38 through the third pipeline 52, and under the action of rotating air flow, the air in the air cavity 38 carries high-content atomized liquid medicament and is then inhaled by a user, and the inhalation device can absorb the liquid medicament at the same time through the injection device; and when cleaning the suction device, can also add the cleaner in the liquid storage chamber 53, the air current drives the atomized cleaning machine and disinfects the whole suction device automatically, has reduced the degree of difficulty that the manual work was cleared up threaded pipe 9.
In one embodiment, the suction tube is further provided with a concentration detection device, the shell is provided with a controller and a reminding lamp, the concentration detection device and the reminding lamp are electrically connected with the controller, and the concentration of the medicine in the suction tube is detected through the concentration detection device, and the steps are as follows:
step 1: the light transmittance of the light transmitted in the medicament is calculated by the following formula:
where e is a constant, A is an optical path, pi is a constant, B is an empirical constant related to wavelength,for the wavelength of incident light, m is the scale spectrum distribution of the medicament particles, L is the diameter of the medicament particles, G is the intensity of transmitted light, G 0 Is the intensity of incident light;
step 2: the concentration of the drug in the inhalation tube was calculated as follows:
wherein pi is a constant, ρ 0 To assume the standard density of the drug particles ρ L The relative density, m is the size spectrum distribution of the medicament particles, and L is the particle size of the medicament particles;
step 3, the following formulas can be obtained through the steps 1 and 2;
N＝-ρ 0 ρ L kGmF
wherein k is a constant value, and the formula is shown in the specification,
step 5: comparing the concentration of the medicine in the suction tube with a preset value, and reminding the lamp not to work if the concentration of the medicine in the suction tube is larger than the preset value; if the concentration of the medicament is smaller than the preset value, the reminding lamp starts working.
The technical scheme has the working principle and beneficial effects that: the concentration detection device calculates the concentration of the traditional Chinese medicine in the suction pipe through constructing a reasonable algorithm, compares the concentration of the traditional Chinese medicine in the suction pipe with a preset value, and reminds the lamp of not working if the concentration of the traditional Chinese medicine in the suction pipe is larger than the preset value; if the concentration of the medicine in the suction tube is smaller than the preset value, the reminding lamp starts to work and sends out a reminding, a user can judge the concentration of the medicine in the suction tube according to whether the reminding lamp is started, and when the user receives the reminding of the reminding lamp, the fact that the concentration of the medicine in the suction tube is too low is indicated, whether the medicine is sucked or not is detected, or the suction device is overhauled is detected.
In one embodiment, the suction nozzle 1 is sleeved with a dust cover.
The working principle of the technical scheme has the beneficial effects that: the dust cover can play a dust-proof role on the suction pipe 5 when the suction nozzle 1 is not used, so that the dust is prevented from entering the suction pipe to affect the next use.
In one embodiment, the outer wall of the pressing sleeve 18 is provided with anti-slip patterns.
The technical scheme has the working principle and beneficial effects that: the provision of anti-slip patterns allows for hand slip when the compression sleeve 18 is depressed.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present invention.
In the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; may be mechanically connected, may be electrically connected or may be in communication with each other; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
Although embodiments of the present invention have been disclosed above, it is not limited to the details and embodiments shown and described, it is well suited to various fields of use for which the invention would be readily apparent to those skilled in the art, and accordingly, the invention is not limited to the specific details and illustrations shown and described herein, without departing from the general concepts defined in the claims and their equivalents.

Claims (8)

1. An inhalation device for soft-ball particulate drug delivery, comprising:
the medicine placing device (2), wherein a suction nozzle (1) is arranged at the top end of the medicine placing device (2), a bottom cover (3) is arranged at the bottom end of the medicine placing device (2), and two needling devices (4) are symmetrically arranged on the medicine placing device (2);
the drug delivery device (2) comprises:
the device comprises a shell (10), wherein a rotary groove (12) is formed in the top end of the shell (10), and a limit groove (13) is formed in the bottom end of the inner wall of the rotary groove (12);
the two air inlet channels (14) are arranged on the side wall of the rotary groove (12) in a central symmetry mode;
a filtering device (24) is further arranged on the side wall of the air inlet channel (14), and the filtering device (24) comprises:
the shielding groove (25) is formed in the inner wall of the air inlet channel (14), a shielding block (26) is connected in a sliding mode in the shielding groove (25), and an air nozzle (27) is formed in the shielding block (26);
a threaded pipe (28), wherein one end of the threaded pipe (28) is communicated with the air nozzle (27), and the other end of the threaded pipe (28) stretches into the shielding groove (25);
a fixing plate (29), wherein the fixing plate (29) is fixedly arranged on the inner wall of the shielding groove (25), and the threaded pipe (28) slides through the fixing plate (29);
the top end of the thread sleeve (31) is rotationally connected with the bottom end of the connecting sleeve (30), the connecting sleeve (30) is connected with the bottom end of the fixed plate (29), and the thread sleeve (31) is sleeved on the thread pipe (28) through threads;
the miniature motor (32) is arranged on the inner wall of the shielding groove (25), the miniature motor (32) is connected with a gear (34) through a first rotating rod (33), and the gear (34) is meshed with the outer wall of the threaded sleeve (31);
the filter block (37), the said filter block (37) locates one side of the said body (10), there are air chambers (38) in the said filter block (37);
the corrugated pipe (35), one end of the corrugated pipe (35) is connected with the threaded pipe (28), the other end of the corrugated pipe (35) is connected with a first pipeline (36), and the other end of the first pipeline (36) stretches into the filter block (37) to be communicated with the air cavity (38);
the fan (43) is arranged in the filter block (37), and the fan is connected with the air cavity (38) through a second pipeline (42);
the heating block (41) is sleeved on the second pipeline (42), and the heating block (41) is positioned between the air cavity (38) and the fan (43);
the rotary barrel (40), one end of the rotary barrel (40) stretches into the air cavity (38) to be fixedly connected with the spray ball (39), the other end of the rotary barrel (40) is rotationally connected with the second pipeline (42), a plurality of rotary blades (46) are uniformly arranged on the inner wall of the rotary barrel (40), and the rotary blades (46) are obliquely arranged around the circle center of the rotary barrel (40) in the clockwise direction;
the spraying ball device comprises a spraying cavity (44), wherein the spraying cavity (44) is arranged in the spraying ball (39), a plurality of spraying holes (45) are uniformly formed in the inner wall of the spraying cavity (44), and the spraying holes (45) are obliquely arranged around the circle center of the spraying cavity (44) in the anticlockwise direction.
2. An inhalation device for soft-ball particulate drug delivery according to claim 1, wherein,
the suction nozzle (1) comprises:
the suction pipe (5), the suction pipe (5) is arranged at the top end of the cover plate (6), and a rotating block (7) is arranged at the bottom end of the cover plate (6);
the rotating groove (11) is formed in the shell (10), the rotating groove (11) is formed in one side of the rotating groove (12), and the rotating block (7) is connected in the rotating groove (11) in a rotating mode;
the clamping plate (15) is arranged at the top end of the shell (10), and the clamping plate (15) is positioned at one side of the rotating groove (11);
the clamping block (8) is arranged at the bottom end of the cover plate (6), and the clamping block (8) is positioned at one side far away from the rotating block (7);
a spiral channel (9), wherein the spiral channel (9) is arranged on the inner wall of the suction pipe (5);
and the grid net (23) is arranged on the cover plate (6).
3. An inhalation device for soft-ball particulate drug delivery according to claim 1, wherein,
the needling apparatus (4) comprises:
a pressing groove (17), wherein the pressing groove (17) is arranged in the shell (10), and the pressing groove (17) is positioned at one side of the rotary groove (12);
a pressing sleeve (18), wherein the pressing sleeve (18) is connected in the pressing groove (17) in a sliding manner;
a needle (20), wherein one end of the needle (20) is arranged in the pressing sleeve (18) through a needle seat (19), and the other end of the needle (20) extends into the limit groove (13);
and a pressing spring (21), wherein the pressing spring (21) is arranged between the pressing sleeve (18) and the pressing groove (17).
4. An inhalation device for soft-ball particulate drug delivery according to claim 1, wherein,
the bottom cover (3) is provided with a mounting fixture block (22), and the mounting fixture block (22) is clamped on the shell (10).
5. An inhalation device for soft-ball particulate drug delivery according to claim 3 characterised in that,
the side of the needle (20) far away from the needle seat (19) is provided with a three-sided needle point.
6. An inhalation device for soft-ball particulate drug delivery according to claim 1, wherein,
an injection device is also arranged in the filter block (37), and the injection device comprises:
the transmission cavity (56) is arranged in the filter block (37), the transmission cavity (56) is positioned between the air cavity (38) and the fan (43), and the rotary cylinder (40) penetrates through the transmission cavity (56);
the liquid storage cavity (53) is arranged in the filter block (37), and the liquid storage cavity (53) is connected with the air cavity (38) through a third pipeline (52);
the first driving wheel (47) is sleeved on the rotating cylinder (40), and the first driving wheel (47) is positioned in the driving cavity (56);
one end of the second rotating rod (50) is rotationally connected with the inner wall of the transmission cavity (56), and the other end of the second rotating rod (50) stretches into the third pipeline (52) to be connected with the water control gear (51);
the second driving wheel (49) is sleeved on the second rotating rod (50), the second driving wheel (49) is positioned in the driving cavity (56), and the second driving wheel (49) is in driving connection with the first driving wheel (47) through a belt (48);
the sliding plate (54), sliding plate (54) sliding connection in stock solution chamber (53), sliding plate (54) with be equipped with extrusion spring (55) between the inner wall of stock solution chamber (53).
7. An inhalation device for soft-ball particulate drug delivery according to claim 1, wherein,
a dust cover is sleeved on the suction nozzle (1).
8. An inhalation device for soft-ball particulate drug delivery according to claim 3 characterised in that,
the outer wall of the pressing sleeve (18) is provided with anti-skid patterns.
CN202211026797.3A 2022-08-25 2022-08-25 Inhalation device for soft ball particle drug delivery Active CN115429986B (en)

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