CN113616886B - Nasal cavity administration dry powder delivery device - Google Patents
Nasal cavity administration dry powder delivery device Download PDFInfo
- Publication number
- CN113616886B CN113616886B CN202110954143.6A CN202110954143A CN113616886B CN 113616886 B CN113616886 B CN 113616886B CN 202110954143 A CN202110954143 A CN 202110954143A CN 113616886 B CN113616886 B CN 113616886B
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- shell
- channel
- tray
- limiting
- dry powder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Abstract
The invention discloses a nasal cavity administration dry powder delivery device, which comprises a shell, wherein a channel is vertically arranged in the shell, a tray is arranged in the channel, a pushing component is arranged at the bottom of the tray, the pushing component is used for pushing the tray to slide in the channel and limiting the position of the tray in the channel, puncture needle components are respectively arranged on the shells at two sides of the channel, and the puncture needle components are used for puncturing a medicine capsule placed on the tray; the periphery of a channel above the needle assembly is provided with an air bin, a blowing nozzle communicated with the air bin is arranged on the shell, a cyclone separation groove is arranged above the air bin, the air bin is communicated with the cyclone separation groove through a left air outlet and a right air outlet, the center of the cyclone separation groove is communicated with the channel, and a nose communicated with the rotary separation groove is arranged at the top of the shell; the invention improves the delivery efficiency of the dry powder medicine in the nasal cavity and improves the bioavailability of the medicine.
Description
Technical Field
The invention relates to a nasal cavity administration dry powder delivery device, and belongs to the technical field of nasal cavity administration.
Background
The nasal administration refers to a mode of administration in which the drug is directly delivered into the nasal cavity through the nostril, drug particles are firstly deposited on a specific area on the inner surface of the nasal cavity, then penetrate through a mucus layer and a mucous membrane epithelial cell layer, and further reach the action part of the drug, so as to treat local diseases of the nasal cavity and brain and systemic diseases; the traditional nasal administration is generally used for treating nasal cavity local diseases (rhinitis, nasal polyp, nasosinusitis and the like) and nasal cavity operation postoperation, and the medicine is directly delivered to a nasal cavity focus, so that the medicine can exert better medicine effect, and toxic and side effects caused by the medicine reaching the whole body tissues through blood circulation can be reduced; in recent years, novel nasal administration has also been used to treat brain diseases and systemic diseases; for brain diseases, due to the existence of blood brain barrier, the conventional administration routes (intravenous injection, oral administration, intramuscular injection and the like) lead to the difficulty of drug molecules entering the brain through blood circulation, and limit the treatment effect of brain diseases (Alzheimer disease, parkinson disease, epilepsy and the like); a large number of researches show that a nasal mucosa and brain have a direct nasal-brain passage, and medicines can directly reach the brain through the nasal-brain passage, so that the limitation of blood brain barrier is avoided, and a novel method is provided for treating brain diseases; because the lower layer of the nasal mucosa epithelial cells is provided with abundant capillaries, the blood flow is abundant, and drug molecules can be absorbed by the nasal mucosa and enter the capillaries, so as to enter the blood circulation for treating systemic diseases, such as nasal delivery of insulin for treating diabetes and the like; since nasal administration has the advantages of avoiding the first pass effect of the liver, improving the effectiveness of the drug entering the brain, having high bioavailability, and the like, the drug has been paid more attention to by more researchers; the nasal delivery device has a critical effect on the bioavailability of the drug, and is especially delivered to the olfactory region position for treating brain diseases, but the traditional nasal delivery dry powder delivery device has low delivery efficiency.
Disclosure of Invention
The invention aims at solving the problems in the prior art and provides a dry powder delivery device for nasal administration, which is used for improving the delivery efficiency of dry powder medicine in nasal cavity and improving the bioavailability of the medicine.
In order to achieve the above object, the present invention adopts the following technical scheme:
the nasal cavity administration dry powder delivery device comprises a shell, wherein a channel is vertically arranged in the shell, a tray is arranged in the channel, a pushing component is arranged at the bottom of the tray and used for pushing the tray to slide in the channel and limiting the position of the tray in the channel, and puncture needle components are respectively arranged on the shells at two sides of the channel and used for puncturing a medicine capsule placed on the tray; the device comprises a shell, a puncture needle assembly, a cyclone separation groove, a shell, a gas bin, a nozzle, a cyclone separation groove, a nose opening and a rotary separation groove, wherein the gas bin is arranged around a channel above the puncture needle assembly, the nozzle is arranged on the shell and communicated with the gas bin, the cyclone separation groove is arranged above the gas bin, the gas bin is communicated with the cyclone separation groove through a left gas outlet and a right gas outlet, the center of the cyclone separation groove is communicated with the channel, and the nose opening communicated with the rotary separation groove is arranged at the top of the shell.
As a further preferred aspect of the present invention, the pushing component includes a stop collar, a stop shaft, and a push rod; the limiting shaft is vertically arranged at the inner bottom of the shell, the limiting sleeve is sleeved on the limiting shaft in a sliding manner, the top end of the limiting sleeve is connected with the bottom of the tray, one end of the push rod is connected with the limiting sleeve, the other end of the push rod extends to the outer side of the shell, and a strip-shaped hole for the push rod to move is formed in the shell; the limiting sleeve is pushed by the push rod, so that the position of the tray in the channel can be adjusted.
As a further preferred mode of the invention, the pushing assembly further comprises a limiting rod and a return spring, wherein the top end of the return spring is connected with the bottom end of the limiting sleeve, the bottom end of the return spring is connected with the inner bottom of the shell, and the return spring is sleeved on the limiting shaft; the shell is provided with an initial limiting hole and a stop limiting hole, one end of the limiting rod is connected with the limiting sleeve, and the other end of the limiting rod is clamped in the initial limiting hole or the stop limiting hole; in the initial state, the other end of the limiting rod is clamped in the initial limiting hole, after the limiting sleeve is pushed upwards by the push rod, the other end of the limiting rod slides out of the initial limiting hole and is clamped in the stop limiting hole, and at the moment, the return spring is stretched; when the other end of the limiting rod clamped in the stop limiting hole is ejected out, the limiting sleeve is pulled back to the initial position by the return spring under the action of the shrinkage elastic force of the return spring.
As a further preferable mode of the invention, a return button is arranged on the outer side surface of the shell, one end of the return button is connected with the outer side surface of the shell, and the other end of the return button corresponds to the stop limiting hole and is provided with a protruding structure used for extending into the stop limiting hole; the return button is used for ejecting the end part of the limiting rod in the stop limiting hole; when the operation is performed, the return button is pressed, so that the protruding structure arranged at the other end of the return button extends into the stop limiting hole, and the protruding structure ejects the end part of the limiting rod clamped in the stop limiting hole.
As a further preferred aspect of the present invention, the lancet assembly includes a button sleeve and a lancet, the lancet is disposed along an axis of the button sleeve, a tail end of the lancet is connected with an inner bottom of the button sleeve, a tip of the lancet extends to an outer side of an opening of the button sleeve, a groove body matched with the button sleeve is formed on the housing, the button sleeve is slidably connected at the groove body, the opening of the button sleeve is located inside the groove body, a bottom of the button sleeve is located outside the groove body, and a through hole for allowing the tip of the lancet to pass through and enter the channel is disposed at the bottom of the groove body; the tip of the spike is forced into the passageway by depressing the button sleeve and puncturing the drug capsule.
As a further preferred mode of the invention, the puncture needle assembly further comprises a reset spring, wherein the reset spring is sleeved on the puncture needle, one end of the reset spring is connected with the bottom in the groove body, and the other end of the reset spring is connected with the inner bottom of the button sleeve; the tip of the spike is forced into the passageway by depressing the button sleeve and puncturing the drug capsule, at which time the return spring is compressed; after the button sleeve is released, the reset spring releases the elastic force to push the button sleeve to reset, so that the tip of the puncture needle withdraws from the medicine capsule and the channel.
As a further preferred aspect of the present invention, the airflow paths communicating with the left air outlet and the right air outlet on both sides at the center of the cyclone separation tank are not on the same straight line; that is, two air flow paths are not oppositely arranged, wherein one air flow path is close to the front side of the shell, and the other air flow path is close to the rear side of the shell; the air flow in the air bin is divided into two flows which respectively enter the cyclone separation groove through the left air outlet and the right air outlet, and the two flows drive the medicine capsules to rotate, so that the medicine powder in the medicine capsules is thrown out under the action of centrifugal force.
As a further preferable mode of the invention, the top of the shell is rotatably connected with a flip cover, the nose opening is arranged on the flip cover, a plurality of through holes are arranged on the flip cover corresponding to the interior of the nose opening, and the plurality of through holes are arranged in an array; after the flip is opened, the used medicine capsules can be taken out, new medicine capsules can be put in, and then the flip is closed, so that the medicine capsules can be reused.
As a further preferable mode of the invention, a limiting groove for limiting the medicine capsules is arranged on the tray; the medicine capsule can be placed according to the form of the limit groove.
As a further preferred aspect of the present invention, the contact surface between the tray and the cyclone separating groove is a step structure; the tightness of the tray when contacting with the center of the cyclone separation groove is improved, and the air flow leakage quantity in the cyclone separation groove is reduced.
The invention has the advantages that:
(1) Firstly, the invention designs a pushing mode of the medicine capsule; a channel is vertically arranged in the shell, a tray is arranged in the channel, a pushing component is arranged at the bottom of the tray and used for pushing the tray to slide in the channel and limiting the position of the tray in the channel, so that the pushing of the medicine capsules is realized;
(2) Secondly, the invention designs a puncturing mode of the medicine capsule; the shell on two sides of the channel is respectively provided with a puncture needle assembly, and the puncture needle assemblies are used for puncturing the medicine capsules placed on the tray and can automatically reset, so that the puncturing of the medicine capsules is realized;
(3) Finally, the invention designs the airflow path; the air bin and the cyclone separation groove are arranged in the shell, and an air flow path is designed, and in the air blowing process, two air flows are utilized to drive the medicine capsule to rotate, so that medicine powder in the medicine capsule is thrown out under the action of centrifugal force, and the thrown medicine powder flows into the nasal cavity along with the air flow through the nose opening, thereby improving the delivery efficiency of the dry powder medicine in the nasal cavity and improving the bioavailability of the medicine.
Drawings
FIG. 1 is a schematic perspective view of a first embodiment of the present invention;
FIG. 2 is a schematic elevational view of a first embodiment of the present invention;
FIG. 3 is a schematic top view of a first embodiment of the present invention;
FIG. 4 is a schematic view showing an internal structure of a tray in an initial position according to an embodiment of the present invention;
FIG. 5 is a schematic view of a spike assembly of an embodiment of the present invention in a spike assembly to puncture a drug capsule;
FIG. 6 is a schematic diagram showing a first embodiment of the present invention when a medicine capsule is pushed into a cyclone separating tank;
FIG. 7 is a schematic diagram II of a first embodiment of the present invention when a drug capsule is pushed into a cyclone separator;
FIG. 8 is a schematic top view of an embodiment of the present invention with the top of the housing removed;
fig. 9 is a schematic perspective view of a second embodiment of the present invention;
FIG. 10 is a schematic side view of a second embodiment of the present invention;
FIG. 11 is a schematic top view of a second embodiment of the present invention;
meaning of reference numerals in the drawings:
1-shell, 2-channel, 3-tray, 4-medicine capsule, 5-gas storehouse, 6-blowing nozzle, 7-cyclone separation groove, 8-left gas outlet, 9-right gas outlet, 10-nose mouth, 11-stop collar, 12-stop shaft, 13-push rod, 14-bar hole, 15-stop lever, 16-return spring, 17-initial stop hole, 18-termination stop hole, 19-return button, 20-limit groove, 21-button sleeve, 22-felting needle, 23-return spring, 24-flip, 25-through hole.
Detailed Description
The invention is described in detail below with reference to the drawings and the specific embodiments.
Example 1
As shown in fig. 1 to 8, the present embodiment is a nasal cavity administration dry powder delivery device, including a housing 1, a channel 2 is vertically arranged in the housing 1, a tray 3 is arranged in the channel 2, a pushing component is arranged at the bottom of the tray 3, the pushing component is used for pushing the tray 3 to slide in the channel 2 and limiting the position of the tray 3 in the channel 2, and needle components are respectively arranged on the housing 1 at two sides of the channel 2, and the needle components are used for puncturing a medicine capsule 4 placed on the tray 3; an air bin 5 is arranged around the channel 2 above the needle assembly, a blowing nozzle 6 communicated with the air bin 5 is arranged on the shell 1, a cyclone separation groove 7 is arranged above the air bin 5, the air bin 5 is communicated with the cyclone separation groove 7 through a left air outlet 8 and a right air outlet 9, the center of the cyclone separation groove 7 is communicated with the channel 2, and a nose 10 communicated with the rotary separation groove 7 is arranged at the top of the shell 1.
In this embodiment, the pushing assembly includes a stop collar 11, a stop shaft 12, and a push rod 13; the limiting shaft 12 is vertically arranged at the inner bottom of the shell 1, the limiting sleeve 11 is sleeved on the limiting shaft 12 in a sliding manner, the top end of the limiting sleeve 11 is connected with the bottom of the tray 3, one end of the push rod 13 is connected with the limiting sleeve 11, the other end of the push rod 13 extends to the outer side of the shell 1, and a strip-shaped hole 14 for the push rod 13 to move is formed in the shell 1; the limiting sleeve 11 is pushed by the push rod 13, so that the position of the tray 3 in the channel 2 is adjusted; the pushing assembly further comprises a limiting rod 15 and a return spring 16, the top end of the return spring 16 is connected with the bottom end of the limiting sleeve 11, the bottom end of the return spring 16 is connected with the inner bottom of the shell 1, and the return spring 16 is sleeved on the limiting shaft 12; an initial limiting hole 17 and a termination limiting hole 18 are formed in the shell 1, one end of the limiting rod 15 is connected with the limiting sleeve 11, and the other end of the limiting rod is clamped in the initial limiting hole 17 or the termination limiting hole 18; in the initial state, the other end of the limiting rod 15 is clamped in the initial limiting hole 17, after the limiting sleeve 11 is pushed upwards by the push rod 13, the other end of the limiting rod 15 slides out of the initial limiting hole 17 and is clamped in the stop limiting hole 18, and at the moment, the return spring 16 is stretched; after the other end of the limiting rod 15 clamped in the stop limiting hole 18 is ejected out, the limiting sleeve 11 is pulled back to the initial position by the return spring 16 under the action of the shrinkage elastic force of the return spring 16.
In the embodiment, a return button 19 is arranged on the outer side surface of the shell 1, one end of the return button 19 is connected with the outer side surface of the shell 1, and the other end of the return button 19 corresponds to the stop limiting hole 18 and is provided with a protruding structure for extending into the stop limiting hole 18; the return button 19 is used for ejecting the end part of the limiting rod 15 in the stop limiting hole 18; when the operation is performed, the return button 19 is pressed, so that a protruding structure arranged at the other end of the return button 19 stretches into the stop limiting hole 18, and the protruding structure ejects the end part of the limiting rod 15 clamped in the stop limiting hole 18.
In this embodiment, the lancet assembly includes a button sleeve 21 and a lancet 22, the lancet 22 is disposed along an axis of the button sleeve 21, a tail end of the lancet 22 is connected with an inner bottom of the button sleeve 21, a tip of the lancet 22 extends to an outer side of an opening of the button sleeve 21, a groove body matched with the button sleeve 21 is formed on the housing 1, the button sleeve 21 is slidably connected at the groove body, the opening of the button sleeve 21 is located inside the groove body, a bottom of the button sleeve 21 is located outside the groove body, and a through hole for allowing the tip of the lancet 22 to pass through and enter the channel 2 is disposed at the bottom of the groove body; the tip of the spike 22 is caused to enter the channel 2 and pierce the drug capsule 4 by pressing the button sleeve 21; the puncture needle assembly further comprises a return spring 23, the return spring 23 is sleeved on the puncture needle 22, one end of the return spring 23 is connected with the inner bottom of the groove body, and the other end of the return spring is connected with the inner bottom of the button sleeve 21; by pressing the button sleeve 21 the tip of the spike 22 is forced into the channel 2 and pierces the drug capsule 4, at which time the return spring 23 is compressed; after releasing the button sleeve 21, the return spring 23 releases the elastic force to push the button sleeve 21 to return, so that the tip of the puncture needle 22 is withdrawn from the medicine capsule 4 and the channel 2.
In the embodiment, the two sides of the center of the cyclone separation groove 7 are not on the same straight line with the airflow paths communicated with the left air outlet 8 and the right air outlet 9; i.e. two air flow paths are not arranged in opposition, one of which is close to the front side of the housing 1 and the other one is close to the rear side of the housing 1; the air flow in the air bin 5 is divided into two flows which respectively enter the cyclone separation groove 7 through the left air outlet 8 and the right air outlet 9, and the two flows drive the medicine capsule 4 to rotate, so that the medicine powder in the medicine capsule 4 is thrown out under the action of centrifugal force.
In the embodiment, a limiting groove 20 for limiting the medicine capsule 4 is arranged on the tray 3; so that the medicine capsule 4 can be placed according to the form of the limit groove 20; the two axial ends of the limiting groove 20 correspond to the two spike assemblies, so that the spike assemblies can conveniently puncture the medicine capsules 4 in the limiting groove 20.
In the embodiment, the contact surface between the tray 3 and the center of the cyclone separation groove 7 is of a step structure; the tightness of the tray 3 when contacting with the center of the cyclone separation groove 7 is improved, and the air flow leakage amount inside the cyclone separation groove 7 is reduced.
Example two
As shown in fig. 9-11, and referring to fig. 4-8, the present embodiment is similar to the first embodiment in structure, except that the top of the housing 1 in the present embodiment is rotatably connected with a flip cover 24, the nose opening 10 is disposed on the flip cover 24, a plurality of through holes 25 are disposed on the flip cover 24 corresponding to the interior of the nose opening 10, and the plurality of through holes 25 are arranged in an array; after the flip cover 24 is opened, the used medicine capsule 4 can be taken out, and a new medicine capsule 4 can be put in, and then the flip cover 24 is closed, so that the medicine capsule can be reused.
The use process of the two embodiments is as follows:
the medicament capsule 4 is placed on the tray 3, the tip of the spike 22 is caused to enter the channel 2 and pierce the medicament capsule 4 by pressing the button sleeve 21, at which time the return spring 23 is compressed; after the button sleeve 21 is released, the reset spring 23 releases the elastic force to push the button sleeve 21 to reset, so that the tip of the puncture needle 22 withdraws from the medicine capsule 4 and the channel 2; the limiting sleeve 11 is pushed upwards by the push rod 13, the limiting sleeve 11 drives the tray 3 to move upwards, the medicine capsules 4 on the tray 3 enter the cyclone separation groove 7 after the tray 3 contacts with the center of the cyclone separation groove 7, in the process, the other end of the limiting rod 15 slides out of the initial limiting hole 17 and is clamped in the stop limiting hole 18, and at the moment, the return spring 16 is stretched; then the nose 10 is inserted into the nasal cavity, the mouth starts to blow after holding the blowing nozzle 6, the air flow enters the air bin 5 from the blowing nozzle 6, the air flow in the air bin 5 is divided into two paths which respectively enter the cyclone separation groove 7 through the left air outlet 8 and the right air outlet 9, the two paths of air flow drive the medicine capsule 4 to rotate, the medicine powder in the medicine capsule 4 is thrown out under the action of centrifugal force, the thrown medicine powder flows into the nasal cavity along with the air flow through the nose 10, and the repeated blowing is carried out until the delivery of the medicine administration of the nasal cavity is completed; after the medicine is fed, the return button 19 is pressed, a protruding structure arranged at the other end of the return button 19 stretches into the stop limit hole 18, the protruding structure ejects the end of the limit rod 15 clamped in the stop limit hole 18, the limit sleeve 11 is pulled back to the initial position downwards by the return spring 16 under the action of the shrinkage elastic force of the return spring 16, and the limit sleeve 11 drives the tray 3 to move to the initial position downwards; if the flip cover 24 is rotatably connected to the top of the housing 1, the flip cover 24 is opened, the used medicine capsule 4 is taken out, a new medicine capsule 4 can be put in, and then the flip cover 24 is closed, so that the medicine capsule can be reused.
The beneficial effects of the invention are as follows:
(1) Firstly, the invention designs a pushing mode of the medicine capsule; a channel is vertically arranged in the shell, a tray is arranged in the channel, a pushing component is arranged at the bottom of the tray and used for pushing the tray to slide in the channel and limiting the position of the tray in the channel, so that the pushing of the medicine capsules is realized;
(2) Secondly, the invention designs a puncturing mode of the medicine capsule; the shell on two sides of the channel is respectively provided with a puncture needle assembly, and the puncture needle assemblies are used for puncturing the medicine capsules placed on the tray and can automatically reset, so that the puncturing of the medicine capsules is realized;
(3) Finally, the invention designs the airflow path; the air bin and the cyclone separation groove are arranged in the shell, and an air flow path is designed, and in the air blowing process, two air flows are utilized to drive the medicine capsule to rotate, so that medicine powder in the medicine capsule is thrown out under the action of centrifugal force, and the thrown medicine powder flows into the nasal cavity along with the air flow through the nose opening, thereby improving the delivery efficiency of the dry powder medicine in the nasal cavity and improving the bioavailability of the medicine.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention.
In the description of the present invention, it should be noted that, unless explicitly stated and limited otherwise, the terms "mounted," "connected," and "configured" are to be construed broadly, and may be, for example, fixedly connected, configured, detachably connected, configured, or integrally connected, configured; can be mechanically or electrically connected; can be directly connected, can also be indirectly connected through an intermediate medium, and can also be the communication between the two elements; the specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
The foregoing has shown and described the basic principles, principal features and advantages of the invention; it will be appreciated by persons skilled in the art that the above embodiments are not intended to limit the invention in any way, and that all technical solutions obtained by means of equivalent substitutions or equivalent transformations fall within the scope of the invention.
Claims (9)
1. The nasal cavity administration dry powder delivery device is characterized by comprising a shell, wherein a channel is vertically arranged in the shell, a tray is arranged in the channel, a pushing component is arranged at the bottom of the tray and used for pushing the tray to slide in the channel and limiting the position of the tray in the channel, and spike components are respectively arranged on the shells at two sides of the channel and used for puncturing a drug capsule placed on the tray; the periphery of a channel above the needle assembly is provided with an air bin, a blowing nozzle communicated with the air bin is arranged on the shell, a cyclone separation groove is arranged above the air bin, the air bin is communicated with the cyclone separation groove through a left air outlet and a right air outlet, the center of the cyclone separation groove is communicated with the channel, and a nose communicated with the rotary separation groove is arranged at the top of the shell;
the two sides of the center of the cyclone separation groove are not on the same straight line with the airflow paths communicated with the left air outlet and the right air outlet.
2. The dry powder delivery device for nasal administration of claim 1, wherein the pushing assembly comprises a stop collar, a stop shaft, and a push rod; the utility model discloses a push rod, including the shell, the stop axle is vertical to be set up in the interior bottom of shell, the stop collar sliding sleeve is epaxial at the stop, and the top and the tray bottom of stop collar are connected, the one end and the stop collar of push rod are connected, and the other end extends to the shell outside, is formed with the bar hole that supplies the push rod to remove on the shell.
3. The dry powder delivery device for nasal administration according to claim 2, wherein the pushing assembly further comprises a limiting rod and a return spring, the top end of the return spring is connected with the bottom end of the limiting sleeve, the bottom end of the return spring is connected with the inner bottom of the shell, and the return spring is sleeved on the limiting shaft; the shell is provided with an initial limiting hole and a stop limiting hole, one end of the limiting rod is connected with the limiting sleeve, and the other end of the limiting rod is clamped in the initial limiting hole or the stop limiting hole.
4. A dry powder delivery device for nasal administration according to claim 3, wherein a return button is provided on the outer side of the housing, one end of the return button is connected to the outer side of the housing, and the other end corresponds to the stop limiting hole and is provided with a protrusion structure for extending into the stop limiting hole.
5. The dry powder delivery device for nasal administration according to claim 1, wherein the spike assembly comprises a button sleeve and a spike, the spike is disposed along an axis of the button sleeve, a tail end of the spike is connected with an inner bottom of the button sleeve, a tip of the spike extends to an outer side of an opening of the button sleeve, a groove body matched with the button sleeve is formed on the shell, the button sleeve is slidably connected at the groove body, the opening of the button sleeve is located inside the groove body, a bottom of the button sleeve is located outside the groove body, and a through hole for the tip of the spike to pass through and enter the channel is formed at the bottom of the groove body.
6. The dry powder delivery device for nasal administration of claim 5, wherein the spike assembly further comprises a return spring, wherein the return spring is sleeved on the spike, one end of the return spring is connected with the bottom in the groove body, and the other end of the return spring is connected with the inner bottom of the button sleeve.
7. The dry powder delivery device for nasal administration according to claim 1, wherein the top of the housing is rotatably connected with a flip cover, the nose opening is arranged on the flip cover, a plurality of through holes are arranged on the flip cover corresponding to the inside of the nose opening, and the plurality of through holes are arranged in an array.
8. The dry powder delivery device for nasal administration of claim 1, wherein the tray is provided with a limiting groove for limiting the drug capsule.
9. A dry powder delivery device for nasal administration as claimed in claim 1 or 8, wherein the contact surface of the tray with the centre of the cyclone separator is of stepped configuration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110954143.6A CN113616886B (en) | 2021-08-19 | 2021-08-19 | Nasal cavity administration dry powder delivery device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110954143.6A CN113616886B (en) | 2021-08-19 | 2021-08-19 | Nasal cavity administration dry powder delivery device |
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| Publication Number | Publication Date |
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| CN113616886A CN113616886A (en) | 2021-11-09 |
| CN113616886B true CN113616886B (en) | 2023-04-28 |
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| CN202110954143.6A Active CN113616886B (en) | 2021-08-19 | 2021-08-19 | Nasal cavity administration dry powder delivery device |
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| CN115429986B (en) * | 2022-08-25 | 2023-07-18 | 苏州易合医药有限公司 | Inhalation device for soft ball particle drug delivery |
| CN115814218B (en) * | 2023-02-14 | 2023-05-26 | 杭州希溪制药有限公司 | Powder aerosol inhalation device with separation preventing structure |
| CN115970106B (en) * | 2023-02-16 | 2023-09-01 | 上海华瑞气雾剂有限公司 | Nasal drug delivery device and method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0420513D0 (en) * | 2004-09-15 | 2004-10-20 | Optinose As | Powder delivery devices |
| GB2477223A (en) * | 2006-11-28 | 2011-07-27 | Optinose As | Nasal delivery system with a replaceable nosepiece unit |
| CN201036654Y (en) * | 2007-02-07 | 2008-03-19 | 郝承红 | Medicinal powder inhaler |
| CN107569752B (en) * | 2012-02-24 | 2021-06-29 | 奥普蒂诺斯公司 | Nasal delivery device |
| CN209392524U (en) * | 2018-10-25 | 2019-09-17 | 塞纳医药包装材料(昆山)有限公司 | A kind of Diskus |
-
2021
- 2021-08-19 CN CN202110954143.6A patent/CN113616886B/en active Active
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| CN113616886A (en) | 2021-11-09 |
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