CN115427064A - 使用基于脂质结合蛋白的复合物治疗急性病况的方法 - Google Patents
使用基于脂质结合蛋白的复合物治疗急性病况的方法 Download PDFInfo
- Publication number
- CN115427064A CN115427064A CN202180028796.XA CN202180028796A CN115427064A CN 115427064 A CN115427064 A CN 115427064A CN 202180028796 A CN202180028796 A CN 202180028796A CN 115427064 A CN115427064 A CN 115427064A
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- Prior art keywords
- lipid
- binding protein
- based complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Marine Sciences & Fisheries (AREA)
- Transplantation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063011055P | 2020-04-16 | 2020-04-16 | |
| US63/011,055 | 2020-04-16 | ||
| US202063092070P | 2020-10-15 | 2020-10-15 | |
| US63/092,070 | 2020-10-15 | ||
| US202063121640P | 2020-12-04 | 2020-12-04 | |
| US63/121,640 | 2020-12-04 | ||
| PCT/IB2021/000283 WO2021209823A1 (en) | 2020-04-16 | 2021-04-15 | Methods for treating acute conditions using lipid binding protein- based complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115427064A true CN115427064A (zh) | 2022-12-02 |
Family
ID=76197484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180028796.XA Pending CN115427064A (zh) | 2020-04-16 | 2021-04-15 | 使用基于脂质结合蛋白的复合物治疗急性病况的方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240033322A1 (https=) |
| EP (1) | EP4135747A1 (https=) |
| JP (1) | JP2023522889A (https=) |
| KR (1) | KR20230004605A (https=) |
| CN (1) | CN115427064A (https=) |
| AU (1) | AU2021256086A1 (https=) |
| CA (1) | CA3177243A1 (https=) |
| IL (1) | IL297336A (https=) |
| MX (1) | MX2022012969A (https=) |
| WO (1) | WO2021209823A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116893215A (zh) * | 2023-03-17 | 2023-10-17 | 安徽省立医院(中国科学技术大学附属第一医院) | 一种用于监测car-t治疗之后crs进程的临床标志物及其应用 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL297046A (en) | 2020-04-16 | 2022-12-01 | Abionyx Pharma Sa | Treatment of kidney disease using cer-001 |
| KR20240018430A (ko) * | 2021-04-15 | 2024-02-13 | 아비오닉스 파마 에스에이 | 기관 보존 용액에서의 지질 결합 단백질-기반 복합체의 사용 |
| CA3247588A1 (en) * | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | METHODS FOR TREATING LEUKOCYTOSIS, ENDOTHELIAL DYSFUNCTION AND CARDITIS USING LIPID-BINDING PROTEIN COMPLEXES |
| JP2025519606A (ja) * | 2022-06-10 | 2025-06-26 | アビオニクス ファーマ エスエー | 脂質結合タンパク質に基づく複合体を使用して急性状態を処置するための方法 |
| WO2023237927A2 (en) * | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Methods for treating hyperinflammatory conditions using lipid binding protein -based complexes |
| WO2024150064A1 (en) * | 2023-01-13 | 2024-07-18 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6953840B2 (en) * | 2002-07-30 | 2005-10-11 | Esperion Therapeutics, Inc. | Methods of using non-human animal Apolipoprotein A-I protein |
| WO2018029505A1 (en) * | 2016-08-11 | 2018-02-15 | Cerenis Therapeutics Holding Sa | Cer-001 therapy for treating familial primary hypoalphalipoproteinemia |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5128318A (en) | 1987-05-20 | 1992-07-07 | The Rogosin Institute | Reconstituted HDL particles and uses thereof |
| GB8712540D0 (en) | 1987-05-28 | 1987-07-01 | Ucb Sa | Expression of human proapolipoprotein a-i |
| US5220043A (en) | 1991-03-21 | 1993-06-15 | Ohio University | Synthesis of D-erythro-sphingomyelins |
| SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
| JP3754072B2 (ja) | 1994-03-22 | 2006-03-08 | リサーチ・コーポレーション・テクノロジーズ・インコーポレーテッド | 摂食抑制ペプチド |
| US6037323A (en) | 1997-09-29 | 2000-03-14 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| US6046166A (en) * | 1997-09-29 | 2000-04-04 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| US6004925A (en) | 1997-09-29 | 1999-12-21 | J. L. Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| AU2001257173B2 (en) | 2000-04-21 | 2005-09-22 | Amgen Inc. | Apo-ai/aii peptide derivatives |
| US6664230B1 (en) | 2000-08-24 | 2003-12-16 | The Regents Of The University Of California | Orally administered peptides to ameliorate atherosclerosis |
| US7199102B2 (en) | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| US7148197B2 (en) | 2000-08-24 | 2006-12-12 | The Regents Of The University Of California | Orally administered small peptides synergize statin activity |
| US7144862B2 (en) | 2000-08-24 | 2006-12-05 | The Regents Of The University Of California | Orally administered peptides to ameliorate atherosclerosis |
| EP2343317A1 (en) | 2000-11-10 | 2011-07-13 | F. Hoffmann-La Roche Ltd. | Apolipoprotein analogues |
| US7217785B2 (en) | 2001-05-09 | 2007-05-15 | The Regents Of The University Of California | Cysteine-containing peptides having antioxidant properties |
| CA2457840C (en) | 2001-08-20 | 2011-10-11 | Zlb Bioplasma Ag | Hdl for the treatment of stroke and other ischemic conditions |
| US7223726B2 (en) | 2002-01-14 | 2007-05-29 | The Regents Of The University Of California | Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same |
| AU2003239489A1 (en) | 2002-05-17 | 2003-12-02 | Esperion Therapeutics, Inc. | Method of treating dyslipidemic disorders |
| EP2314285B2 (en) | 2003-02-14 | 2019-09-18 | Children's Hospital & Research Center at Oakland | Lipophilic drug delivery vehicle and methods of use thereof |
| CN101076541A (zh) | 2004-07-16 | 2007-11-21 | 塔夫茨大学信托人 | 载脂蛋白a1模拟物及其用途 |
| US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
| AU2006282722A1 (en) | 2005-08-26 | 2007-03-01 | Cerenis Therapeutics Holdings S.A. | Compositions and methods for producing apolipoprotein gene products in lactic acid bacteria |
| US8541236B2 (en) | 2006-12-08 | 2013-09-24 | University Of Washington | Mutant apolipoprotein A-1 polypeptide with increased resistance to oxidation and reactive carbonyls |
| WO2008104890A2 (en) | 2007-02-28 | 2008-09-04 | Cerenis Therapeutics Holding Sa | Compositions and methods for producing apolipoprotein |
| US9173890B2 (en) | 2007-09-20 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
| EA201070517A1 (ru) | 2007-10-23 | 2010-12-30 | Дзе Кливленд Клиник Фаундейшн | Устойчивый к окислителям аполипопротеин а-1 и пептиды-миметики |
| LT2939683T (lt) | 2009-02-16 | 2017-03-27 | Cerenis Therapeutics Holding Sa | Apolipoproteino a-i mimetikai |
| US20130137628A1 (en) | 2010-05-11 | 2013-05-30 | Esperion Therapeutics, Inc. | Dimeric Oxidation-Resistant Apolipoprotein A1 Variants |
| EP2673296B1 (en) * | 2011-02-07 | 2018-10-24 | Cerenis Therapeutics Holding SA | Lipoprotein complexes and manufacturing and uses thereof |
| JP6438417B2 (ja) | 2013-03-15 | 2018-12-12 | セレニス セラピューティクス ホールディング エスアー | スフィンゴミエリンおよびジヒドロスフィンゴミエリンの合成のための方法 |
| US9708354B2 (en) | 2013-03-15 | 2017-07-18 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| EP2853259A1 (en) * | 2013-09-30 | 2015-04-01 | Université Pierre et Marie Curie (Paris 6) | Reconstituted high density lipoproteins composition and uses thereof |
| WO2015173633A2 (en) | 2014-05-02 | 2015-11-19 | Cerenis Therapeutics Holding Sa | Hdl therapy markers |
| FR3100715B1 (fr) * | 2019-09-12 | 2023-09-29 | Francais Du Sang Ets | Utilisation de HDL dans la prophylaxie de la maladie du greffon contre l’hôte |
-
2021
- 2021-04-15 KR KR1020227039569A patent/KR20230004605A/ko active Pending
- 2021-04-15 AU AU2021256086A patent/AU2021256086A1/en active Pending
- 2021-04-15 MX MX2022012969A patent/MX2022012969A/es unknown
- 2021-04-15 IL IL297336A patent/IL297336A/en unknown
- 2021-04-15 JP JP2022562954A patent/JP2023522889A/ja active Pending
- 2021-04-15 WO PCT/IB2021/000283 patent/WO2021209823A1/en not_active Ceased
- 2021-04-15 CA CA3177243A patent/CA3177243A1/en active Pending
- 2021-04-15 US US17/918,641 patent/US20240033322A1/en active Pending
- 2021-04-15 EP EP21728972.7A patent/EP4135747A1/en active Pending
- 2021-04-15 CN CN202180028796.XA patent/CN115427064A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6953840B2 (en) * | 2002-07-30 | 2005-10-11 | Esperion Therapeutics, Inc. | Methods of using non-human animal Apolipoprotein A-I protein |
| WO2018029505A1 (en) * | 2016-08-11 | 2018-02-15 | Cerenis Therapeutics Holding Sa | Cer-001 therapy for treating familial primary hypoalphalipoproteinemia |
Non-Patent Citations (6)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116893215A (zh) * | 2023-03-17 | 2023-10-17 | 安徽省立医院(中国科学技术大学附属第一医院) | 一种用于监测car-t治疗之后crs进程的临床标志物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021209823A1 (en) | 2021-10-21 |
| AU2021256086A1 (en) | 2022-12-15 |
| KR20230004605A (ko) | 2023-01-06 |
| CA3177243A1 (en) | 2021-10-21 |
| IL297336A (en) | 2022-12-01 |
| MX2022012969A (es) | 2022-11-09 |
| US20240033322A1 (en) | 2024-02-01 |
| JP2023522889A (ja) | 2023-06-01 |
| EP4135747A1 (en) | 2023-02-22 |
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