CN115403810B

CN115403810B - High oleophobic pipette tip and preparation method thereof

Info

Publication number: CN115403810B
Application number: CN202211230887.4A
Authority: CN
Inventors: 林云辉; 李巧玲
Original assignee: Zhejiang Shoukang Biotechnology Co ltd
Current assignee: Zhejiang Shoukang Biotechnology Co ltd
Priority date: 2022-09-29
Filing date: 2022-09-29
Publication date: 2023-06-27
Anticipated expiration: 2042-09-29
Also published as: CN115403810A

Abstract

The application relates to the technical field of biological and chemical detection, in particular to a high oleophobic pipette tip and a preparation method thereof. The gun head of the high oleophobic pipetting gun is prepared from the following raw materials in parts by weight: 25-35 parts of epoxy resin, 8-12 parts of 2, 2-bisphenol hexafluoropropane diglycidyl ether, 5-10 parts of fluorosilicone resin, 5-10 parts of latent curing agent dicyandiamide and 4-6 parts of dispersing agent BYK-163; the preparation method comprises the following steps: (1) preparing a high oleophobic epoxy resin base solution; (2) preparing a high oleophobic epoxy pretreatment; (3) preparing a pretreatment pipette tip; (4) preparing the gun head of the high oleophobic pipetting gun. The gun head of the high oleophobic pipetting gun can be used for sucking the oily liquid in a laboratory, and has the advantage of high oleophobicity; in addition, the preparation method has the advantage of improving the oleophobicity of the gun head of the pipetting gun.

Description

High oleophobic pipette tip and preparation method thereof

Technical Field

The application relates to the technical field of biological and chemical detection, in particular to a high oleophobic pipette tip and a preparation method thereof.

Background

A pipette is a laboratory compact test instrument for pipetting small or minute amounts of liquid. When the liquid is sucked, the gun head of the liquid dispenser is vertically inserted into the liquid to be detected, and then the piston in the liquid dispenser is pressed, so that the liquid to be detected is forced to be transferred into the liquid dispenser under the action of the piston, and the liquid to be detected is sucked.

In the related art, for example, patent document with the publication number CN103962193B discloses a pipette gun head, which mainly comprises a liquid sucking end for sucking liquid to be measured, a liquid storing end for storing the liquid to be measured, and a connecting part for connecting the pipette gun, wherein the liquid sucking end, the liquid storing cavity and the tail are sequentially connected, and the liquid sucking end, the liquid storing cavity and the tail are all made of silicate glass.

In view of the above, the inventors believe that the material of the pipette tip is silicate glass, and the silicate glass has a certain adhesiveness to the oily liquid, so that the pipette tip is likely to have a sink of residual oily liquid droplets when the pipette tip sucks the oily liquid.

Disclosure of Invention

In order to reduce the amount of residual oily liquid drops of a gun head of a liquid-transfering gun, the application provides a gun head with high oleophobic property and a preparation method thereof.

In a first aspect, the present application provides a gun head of a high oleophobic pipette, which adopts the following technical scheme:

the gun head of the high oleophobic pipetting gun comprises the following raw materials in parts by weight: 25-35 parts of epoxy resin, 8-12 parts of 2, 2-bisphenol hexafluoropropane diglycidyl ether, 5-10 parts of fluorosilicone resin, 15-25 parts of latent curing agent dicyandiamide and 4-6 parts of dispersing agent BYK-163.

By adopting the technical scheme, the bisphenol hexafluoropropylene diglycidyl ether is adopted as the fluorinating agent to fluorinate the epoxy resin, so that the oleophobicity of the epoxy resin is effectively improved, and the specific certain dredging effect of the cured pipette tip on the oily liquid is promoted, so that the effect of reducing the residual oily liquid drop of the pipette tip is obtained.

In addition, the fluorine-silicon resin also has excellent oleophobic performance, so that after the epoxy resin is solidified to obtain the gun head of the liquid-transferring gun, the fluorine-silicon resin can coat the surface of the gun head of the liquid-transferring gun, and the quantity of residual oily liquid drops of the gun head of the liquid-transferring gun is further reduced through the effect of the fluorine-silicon resin on the dredging of the oily liquid drops.

Preferably, the water-based paint further comprises 15-25 parts of oleophobic treatment liquid, wherein the additive is one or a combination of two of fluorosilicone and methyl diphenyl silanol.

By adopting the technical scheme, because the fluorosilicone also has excellent oleophobic performance, after the epoxy resin is solidified to obtain the gun head of the liquid-transfer gun, the fluorosilicone can also coat the surface of the gun head of the liquid-transfer gun, and the quantity of residual oily liquid drops of the gun head of the liquid-transfer gun is further reduced through the lyophobic effect of the fluorosilicone on the oily liquid drops.

In addition, when the pipette tip coated with the fluorosilicone is soaked in methyl diphenyl silanol, the siloxane of the fluorosilicone reacts with silanol groups in the methyl diphenyl silanol, so that the surface energy of the fluorosilicone is effectively reduced, the oleophobicity of the fluorosilicone is indirectly improved, and the amount of residual oily liquid drops of the pipette tip is further reduced.

Preferably, the oleophobic treatment fluid is prepared from the following raw materials in parts by weight: 5-10 parts of fluorosilicone and 10-15 parts of methyldiphenylsilanol.

Through adopting above-mentioned technical scheme, when fluorosilicone in epoxy resin when this proportion scope, fluorosilicone can be totally to the surface cladding of liquid-transfering gun rifle head, through reducing the production in the surperficial space of liquid-transfering gun rifle head, further reduces the volume of liquid-transfering gun rifle head residual oily liquid drop.

In addition, when the ratio of methyldiphenylsilanol to fluorosilicone is in this range, methyldiphenylsilanol can be completely in contact with the outer peripheral surface of fluorosilicone, and further, the reaction between methyldiphenylsilanol and fluorosilicone can be promoted more sufficiently, and the amount of residual oily liquid droplets at the tip of the pipette tip can be further reduced.

Preferably, the fiber also comprises 8-12 parts of oleophobic fibers, wherein the oleophobic fibers are one or a combination of two of graphite fluoride fibers and titanium dioxide fibers.

Through adopting above-mentioned technical scheme, because graphite fluoride fiber and titanium dioxide fiber all have certain oleophobic effect for after epoxy mixes and solidifies and obtain the liquid-transfering gun rifle head with graphite fluoride fiber and titanium dioxide fiber, can further improve the oleophobic effect of liquid-transfering gun rifle head, and then effectively reduce the volume of liquid-transfering gun rifle head residual oily liquid drop.

In addition, the graphite fluoride fiber and the titanium dioxide fiber also have certain toughness, so that after the epoxy resin, the graphite fluoride fiber and the titanium dioxide fiber are mixed and solidified to obtain the pipette tip, the mechanical property of the pipette tip can be effectively improved, and the possibility of cracking of the high oleophobic pipette tip is reduced.

In addition, when the fluorosilicone resin and the fluorosilicone are cured, the graphite fluoride fiber and the titanium dioxide fiber can be compatible at high temperature, so that the oleophobicity of the pipette tip is further improved, and the amount of residual oily liquid drops of the pipette tip is indirectly reduced.

Preferably, the oleophobic fiber is prepared from the following raw materials in parts by weight: 4-6 parts of graphite fluoride fiber and 4-6 parts of titanium dioxide fiber.

Through adopting above-mentioned technical scheme, when graphite fluoride fibre and titanium dioxide fibre under this proportion scope, graphite fluoride fibre and titanium dioxide fibre can carry out abundant compatilize, further improve the oleophobicity of liquid-transfering gun rifle head, indirectly reduce the volume of liquid-transfering gun rifle head residual oily liquid drop.

Preferably, 4-6 parts of leveling agent KMT-5510S and 4-6 parts of defoaming agent BYK-A530 are also included.

Through adopting above-mentioned technical scheme, owing to the setting of flatting agent and defoaming agent for after the epoxy solidification obtains the liquid-transfering gun rifle head, can effectively reduce the surface of liquid-transfering gun rifle head and appear bubble and the bellied possibility in surface, indirectly improve the smoothness that slides of oily liquid drop, and then reduce the quantity of liquid-transfering gun rifle head residual oily liquid drop.

In a second aspect, the present application provides a method for preparing a gun head of a high oleophobic pipette, which adopts the following technical scheme: a preparation method of a gun head of a high oleophobic pipetting gun comprises the following steps:

(1) Adding 2, 2-bisphenol hexafluoropropane diglycidyl ether and a dispersing agent BYK-163 into epoxy resin, and then mixing to obtain a high oleophobic epoxy resin base solution;

(2) Adding dicyandiamide serving as a latent curing agent into the high oleophobic epoxy resin base solution, and then mixing to obtain a high oleophobic epoxy resin pretreatment material;

(3) Filling the high oleophobic epoxy resin pretreatment material into a mold, and then heating and curing to obtain a pretreatment pipette tip;

(4) And (3) coating the fluorine-silicon resin on the outer surface of the gun head of the pretreatment pipetting gun, and then heating and baking again to obtain the gun head of the high oleophobicity pipetting gun.

Through adopting above-mentioned technical scheme, (4), because carry out the smearing of fluorine silicone resin after the epoxy solidifies and obtain the rifle head of liquid-transfering gun for fluorine silicone resin can even effectual adhesion in the surface of liquid-transfering gun rifle head, through reducing the production in the surperficial space of liquid-transfering gun rifle head, further improve the oleophobicity of liquid-transfering gun rifle head, reduce the volume of liquid-transfering gun rifle head residual oily liquid drop.

Preferably, in (3), the heating temperature is 80-120℃and the heating time is 0.5-1.5 hours.

Through adopting above-mentioned technical scheme, (4) under this heating temperature and heating time, not only can guarantee the solidification of epoxy, can also reduce the possibility that epoxy takes place the bumping, indirectly reduce hole or bellied production, further reduce the quantity of the residual oily liquid drop of liquid-transfering gun rifle head.

Preferably, in (4), the heating temperature is 150-170℃and the heating time is 0.5-1.5h.

By adopting the technical scheme, (5) under the heating temperature and the heating time, the curing of the fluorosilicone resin can be ensured, the possibility of bumping of the fluorosilicone resin can be reduced, the generation of holes or bulges can be indirectly reduced, and the amount of residual oily liquid drops at the gun head of the pipetting gun can be further reduced.

In summary, the present application has the following beneficial effects:

1. the bisphenol hexafluoropropylene diglycidyl ether is adopted as a fluorinating agent to fluorinate the epoxy resin, so that the oleophobicity of the epoxy resin is effectively improved, and the effect of reducing the amount of residual oily liquid drops at the gun head of the pipetting gun is achieved.

2. In the present application, the surface of the pipette tip is preferably coated with the fluorosilicone resin, and the amount of residual oily liquid drops of the pipette tip is further reduced by the effect of the fluorosilicone resin on the separation of the oily liquid drops.

3. According to the method, the method that the fluorine silicone resin is smeared after the epoxy resin is solidified to obtain the gun head of the liquid-transferring gun is adopted, so that the generation of surface gaps of the gun head of the liquid-transferring gun is effectively reduced, and the effect of reducing the amount of residual oily liquid drops of the gun head of the liquid-transferring gun is achieved.

Detailed Description

The present application is described in further detail below with reference to examples and comparative examples.

The raw material components in the application are shown in table 1:

TABLE 1 sources of the raw material components

Examples

Example 1

A gun head of a high oleophobic pipetting gun adopts the following preparation method,

(1) 10g of 2, 2-bisphenol hexafluoropropane diglycidyl ether and 5g of dispersant BYK-163 were added to 30g of epoxy resin, followed by stirring at a stirring speed of 500r/min for 30min to obtain a high oleophobic epoxy resin base liquid;

(2) Adding 20g of a latent curing agent dicyandiamide into the high oleophobic epoxy base liquid, and then stirring for 30min at a stirring speed of 500r/min to obtain a high oleophobic epoxy resin pretreatment material;

(3) Filling the high oleophobic epoxy resin pretreatment material into a mold, and then heating for 1h at the temperature of 100 ℃ to obtain a pretreatment pipette tip;

(4) 8g of fluorosilicone resin is smeared on the outer surface of the gun head of the pretreatment liquid-transfering gun, and then baked for 1h at 160 ℃ to obtain a plurality of gun heads with high oleophobicity.

Examples 2 to 3

The difference from example 1 is that the weight of the components of the raw materials of examples 2-3 are different, as shown in Table 2.

TABLE 2 weight (g) of the raw material components in examples 1 to 3

Examples 4 to 5

The difference from example 1 is that the ratio of 2, 2-bisphenol hexafluoropropane diglycidyl ether to epoxy resin in examples 4-5 is different, as shown in Table 3.

TABLE 3 raw material components and weights (g) of the raw material components in examples 1 and 4 to 5

Examples 6 to 7

The difference from example 1 is that the ratio of fluorosilicone resin to epoxy resin in examples 6-7 is different, as shown in Table 4.

Table 4 Each raw material component and weight (g) thereof in examples 1 and 6 to 7

Composition of raw materials	Example 1	Example 6	Example 7
				Fluorosilicone resin	8	5	10
Epoxy resin	30	30	30

Example 8

The difference from example 1 is that in (4), the outer surface of the tip of the pretreated pipette tip was also coated with 8g of fluorosilicone before baking, and then immersed in 12g of methyldiphenylsilanol.

Examples 9 to 16

The difference from example 8 is that the fluorosilicones in examples 9-16 differ from methyldiphenylsilanol in weight, as shown in Table 5.

TABLE 5 weight (g) of the raw material components in examples 8 to 16

Example 17

The difference from example 8 is that in (4), fluorosilicone is applied to the outer surface of the tip of the pretreated pipette tip first, fluorosilicone is applied later, and finally soaking is performed in methyldiphenylsilanol.

Example 18

The difference from example 1 is that in (1), 5g of graphite fluoride fiber and 5g of titanium dioxide fiber are also added.

Examples 19 to 226

The difference from example 18 is that the graphite fluoride fibers of examples 19-26 differ from the titanium dioxide fibers in weight, as shown in Table 6.

TABLE 6 raw material components and weights (g) of the raw material components in examples 18 to 26

Composition of raw materials	Example 18	Example 19	Example 20	Example 21	Example 22
						Fluorinated graphite fibers	5	4	6	5	5
Titanium dioxide fiber	5	4	6	4	6
							Example 23	Example 24	Example 25	Example 26
Fluorinated graphite fibers	6	4	0	10
						Titanium dioxide fiber	5	5	10	0

Example 27

The difference from example 1 is that in (1), 5g of leveling agent KMT-5510S was also added.

Example 28

The difference from example 1 is that in (1), 4g of leveling agent KMT-5510S was also added.

Example 29

The difference from example 1 is that 6g of leveling agent KMT-5510S was added in (1).

Example 30

The difference from example 1 is that in (1), 5g of defoamer BYK-A530 is also added.

Example 31

The difference from example 1 is that in (1), 4g of defoamer BYK-A530 is also added.

Example 32

The difference from example 1 is that in (1), 6g of defoamer BYK-A530 is also added.

Example 33

The difference from example 1 is that (3) the fluorosilicone resin was directly mixed with the high oleophobic epoxy pretreatment, then directly filled into a mold, and heated at 100 ℃ for 1 hour to obtain a high oleophobic pipette tip.

Example 34

The difference from example 33 is that the heating temperature in (3) was 160 ℃.

Example 35

The difference from example 1 is that in (3), the heating temperature was 80℃and the heating time was 0.5h.

Example 36

The difference from example 1 is that in (3), the heating temperature was 120℃and the heating time was 1.5 hours.

Example 37

The difference from example 1 is that in (4), the heating temperature was 150℃and the heating time was 0.5h.

Example 38

The difference from example 1 is that in (4), the heating temperature was 170℃and the heating time was 1.5 hours.

Comparative example

Comparative example 1

The difference from example 1 is that comparative example 1 is a pipette tip as described in the background art.

Comparative example 2

The difference from example 1 is that in (1), bisphenol hexafluoropropane diglycidyl ether is not added.

Comparative example 3

The difference from example 1 is that in (4), the fluorosilicone resin is not applied.

Comparative example 4

The difference from example 1 is that bisphenol hexafluoropropane diglycidyl ether was not added in (1), and fluorosilicone resin was not applied in (4).

Performance test

Test method

Three samples were taken from examples 1-38 and comparative examples 1-3, respectively, after which the following tests were performed and averaged.

Experiment one, short term oleophobic test

Firstly, weighing 5ml of peanut oil through a container and weighing to obtain an initial weight, then, installing the sample on a liquid-transfering gun, extracting 1000ul of peanut oil through the sample, then, dripping all peanut oil in the liquid-transfering gun into the container and weighing to obtain a first test weight, and finally, calculating the difference between the initial weight and the first test weight and taking an average value.

Experiment two, long term oleophobic test

The difference from experiment one is that after all peanut oil in the pipette was dropped into the vessel, the sample was suspended above the vessel for 24 hours, the vessel after 24 hours was then weighed and a second test weight was obtained, and finally the difference between the initial weight and the second test weight was calculated and averaged.

Detection result: the results of the tests of examples 1 to 38 and comparative examples 1 to 3 are shown in Table 7.

TABLE 7 detection results for examples 1-38 and comparative examples 1-3

As can be seen from the combination of examples 1-3 and comparative example 1 and Table 7, the weight difference (0 h) and the weight difference (24 h) of examples 1-3 are reduced relative to comparative example 1, thus demonstrating that the residual peanut oil of each component of the raw materials can be reduced within the proportion range of examples 1-3, and further the oleophobicity of the gun head of the pipette gun can be effectively improved.

Among them, the weight difference (0 h) and the weight difference (24 h) of example 1 were relatively small compared to examples 2 to 3, thereby demonstrating that the oleophobicity of the pipette tip can be more effectively improved in the ratio range of the raw material components of example 1.

It can be seen in combination with example 1 and examples 4-5 and with Table 7 that the weight difference (0 h) and the weight difference (24 h) of example 4 are slightly reduced, whereas the weight difference (0 h) and the weight difference (24 h) of example 5 are significantly increased, relative to example 1. This demonstrates that as the ratio of 2, 2-bisphenol hexafluoropropane diglycidyl ether to epoxy increases, the oleophobicity of the pipette tip also increases gradually. However, when the ratio of 2, 2-bisphenol hexafluoropropylene diglycidyl ether to epoxy resin is the ratio of example 1, the oleophobic property of the tip of the pipette tip does not improve well even if the amount of 2, 2-bisphenol hexafluoropropylene diglycidyl ether is further added.

It can be seen in combination with example 1 and examples 6-7 and with Table 7 that the weight difference (0 h) and the weight difference (24 h) of example 6 are significantly increased, whereas the weight difference (0 h) and the weight difference (24 h) of example 7 are only slightly decreased, relative to example 1. This demonstrates that as the amount of fluorosilicone increases, the oleophobicity of the pipette tip also increases gradually. However, when the ratio of the fluorosilicone resin to the epoxy resin is the ratio of example 1, the oleophobicity of the tip of the pipette tip does not have a good improvement effect even if the amount of the fluorosilicone resin is further added.

As can be seen from the combination of examples 1 and examples 8-10 and table 7, the weight difference (0 h) and the weight difference (24 h) of examples 8-10 were significantly reduced relative to example 1, thereby demonstrating that fluorosilicone and methyldiphenylsilanol have a significant lifting effect on the oleophobicity of the pipette tip over the ratio range of examples 8-10.

Among them, the weight difference (0 h) and the weight difference (24 h) of example 8 were most significantly reduced compared to examples 9 to 10, thereby demonstrating that the ratio of fluorosilicone to methyldiphenylsilanol in example 8 can more effectively improve the oleophobicity of the pipette tip.

As can be seen from the combination of examples 8 and examples 11-12 and table 7, the weight difference (0 h) and the weight difference (24 h) of example 11 were significantly increased, while the weight difference (0 h) and the weight difference (24 h) of example 12 were slightly decreased, thus indicating that the oleophobicity of the pipette tip was gradually increased as the amount of fluorosilicone increased. However, when the ratio of fluorosilicone to methyldiphenylsilanol was set in example 8, the oleophobicity of the tip of the pipette tip did not improve well even when the amount of fluorosilicone was further added.

As can be seen from the combination of examples 8 and examples 13 to 14 and table 7, the weight difference (0 h) and the weight difference (24 h) of example 13 were significantly increased, while the weight difference (0 h) and the weight difference (24 h) of example 14 were slightly decreased, thus indicating that the oleophobicity of the pipette tip was gradually increased as the amount of methyldiphenylsilanol was increased. However, when the ratio of fluorosilicone to methyldiphenylsilanol was set in example 8, the oleophobicity of the tip of the pipette tip did not improve well even when the amount of methyldiphenylsilanol was further added.

As can be seen in combination with examples 1, 8 and 15-16 and in combination with table 7, the weight difference (0 h) and the weight difference (24 h) of examples 15 and 16 are all significantly increased with respect to example 8, even though the weight difference (0 h) and the weight difference (24 h) of example 15 are substantially the same as those of example 1. Therefore, the fluorosilicone has a certain oleophobic improving effect, but the methyldiphenylsilanol has no oleophobic improving effect, but has a good synergistic effect when the fluorosilicone is used together with the methyldiphenylsilanol, so that the oleophobic of the gun head of the pipetting gun is effectively improved.

As can be seen from the combination of examples 1, 8 and 17 and the table 7, the weight difference (0 h) and the weight difference (24 h) of example 17 are all significantly increased, even though the weight difference (0 h) and the weight difference (24 h) of example 17 are substantially the same as those of example 1, when the coating order of the rich oxygen alkane and the fluorosilicone resin is changed. This further demonstrates that fluorosilicones have a good oleophobic synergistic boost only when used with methyldiphenylsilanol.

As can be seen from the combination of examples 1 and examples 18 to 20 and table 7, the weight difference (0 h) and the weight difference (24 h) of examples 18 to 20 were significantly reduced with respect to example 1, thereby indicating that the graphite fluoride fibers and the titanium dioxide fibers had a certain oleophobic effect under the weight of examples 18 to 20.

The most significant decrease in the weight difference (0 h) and the weight difference (24 h) in example 18 relative to examples 19-20, therefore, demonstrates that the ratio of graphite fluoride fiber to titanium dioxide fiber in example 8 can more effectively increase the oleophobicity of the pipette tip.

As can be seen from the combination of examples 18 and examples 21 to 22 and table 7, the weight difference (0 h) and the weight difference (24 h) of example 21 were significantly increased, while the weight difference (0 h) and the weight difference (24 h) of example 22 were slightly decreased, thus indicating that the oleophobicity of the pipette tip was gradually increased as the amount of titania fibers was increased, as compared with example 18. However, when the ratio of the graphite fluoride fiber to the titanium dioxide fiber in example 18 was used, the oleophobic property of the tip of the pipette tip was not improved even when the fluorosilicone was further added.

As can be seen from the combination of examples 18 and examples 23 to 24 and table 7, the weight difference (0 h) and the weight difference (24 h) of example 23 were slightly decreased, while the weight difference (0 h) and the weight difference (24 h) of example 24 were significantly increased, thereby indicating that the oleophobicity of the pipette tip was gradually increased as the amount of graphite fluoride fibers was increased, as compared with example 18. However, when the ratio of the graphite fluoride fiber to the titanium dioxide fiber is in example 8, the oleophobicity of the tip of the pipette tip does not have a good improvement effect even when the amount of the graphite fluoride fiber is added.

As can be seen in combination with examples 1, 18 and 25-26 and in combination with table 7, the weight difference (0 h) and the weight difference (24 h) of examples 25 and 26 are all significantly increased relative to example 18, but the weight difference (0 h) and the weight difference (24 h) of examples 25 and 26 are still relatively small compared to example 1. Therefore, the graphite fluoride fiber and the titanium dioxide fiber have certain oleophobic improving effect, but when the graphite fluoride fiber and the titanium dioxide fiber are used together, the oleophobic can be further improved.

As can be seen from the combination of examples 1, 27-29 and table 7, the weight difference (0 h) and the weight difference (24 h) of examples 27-29 were significantly reduced relative to example 1, thus demonstrating that the leveling agent KMT-5510S had a significant lifting effect on the oleophobicity of the pipette tip in the ratio range of examples 8-10.

Among them, the weight difference (0 h) and the weight difference (24 h) of example 27 were most significantly reduced compared to examples 28 to 29, thereby demonstrating that the leveling agent KMT-5510S can more effectively improve the oleophobicity of the pipette tip in the ratio range of example 27.

As can be seen from the combination of examples 1, 30-32 and table 7, the weight difference (0 h) and the weight difference (24 h) of examples 30-32 were significantly reduced relative to example 1, thus demonstrating that the defoamer BYK-a530 had a significant lifting effect on the oleophobicity of the pipette tip in the ratio range of examples 30-32.

Among them, the weight difference (0 h) and the weight difference (24 h) of example 30 were most significantly reduced compared to examples 31 to 32, thereby indicating that the antifoaming agent BYK-A530 can more effectively improve the oleophobicity of the pipette tip within the ratio range of example 30.

It can be seen in combination with example 1 and examples 33-34 and with Table 7 that the weight difference (0 h) and the weight difference (24 h) of examples 33-34 are both significantly increased relative to example 1. The reason for this may be that the fluorosilicone resin has not yet completely cured at the temperature of example 33, which results in a certain tackiness of the pipette tip. The temperature of example 33 caused the epoxy to cure and burst, resulting in the presence of air pockets on the surface of the pipette tip and thus residual peanut oil.

It can be seen in combination with example 1 and examples 35-36 and with Table 7 that the weight difference (0 h) and the weight difference (24 h) of examples 35-36 are both significantly increased relative to example 1. The reason for this may be that the epoxy resin is not yet fully cured at the temperature and heating time of example 35, which results in a certain viscosity of the pipette tip. The epoxy resin was prone to pop-up when cured at the temperature and heating time of example 33, resulting in the presence of air bubbles on the surface of the pipette tip and thus residual peanut oil.

It can be seen in combination with example 1 and examples 37-38 and with Table 7 that the weight difference (0 h) and the weight difference (24 h) of examples 37-38 are both significantly increased relative to example 1. The reason for this may be that the fluorosilicone resin has not yet completely cured at the temperature and heating time of example 37, resulting in a certain viscosity of the pipette tip. The fluorosilicone resin was prone to bursting when cured at the temperature and heating time of example 38, resulting in the presence of air bubbles on the surface of the pipette tip and thus residual peanut oil.

It can be seen from the combination of example 1 and comparative examples 2 to 4 and the combination of table 7 that the weight difference (0 h) and the weight difference (24 h) were significantly increased with respect to examples 2 to 4, wherein the increase width of comparative example 4 was the largest. Therefore, bisphenol hexafluoropropylene diglycidyl ether and fluorosilicone resin have certain oleophobic improving effect.

The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.

Claims

1. The gun head of the high oleophobic pipetting gun is characterized by comprising the following raw materials in parts by weight: 25-35 parts of epoxy resin, 8-12 parts of 2, 2-bisphenol hexafluoropropane diglycidyl ether, 5-10 parts of fluorosilicone resin, 15-25 parts of latent curing agent dicyandiamide and 4-6 parts of dispersing agent BYK-163;

the preparation method of the gun head of the high oleophobic pipetting gun comprises the following steps:

2. The high oleophobic pipette tip of claim 1 wherein: the novel water-based paint also comprises 15-25 parts of oleophobic treatment liquid, wherein the oleophobic treatment liquid is one or a combination of two of fluorosilicone and methyl diphenyl silanol.

3. The high oleophobic pipette tip of claim 2 wherein: the oleophobic treatment fluid is prepared from the following raw materials in parts by weight: 5-10 parts of fluorosilicone and 10-15 parts of methyldiphenylsilanol.

4. The high oleophobic pipette tip of claim 1 wherein: the composite material also comprises 8-12 parts of oleophobic fibers, wherein the oleophobic fibers are one or a combination of two of graphite fluoride fibers and titanium dioxide fibers.

5. The high oleophobic pipette tip of claim 4 wherein: the oleophobic fiber is prepared from the following raw materials in parts by weight: 4-6 parts of graphite fluoride fiber and 4-6 parts of titanium dioxide fiber.

6. The high oleophobic pipette tip of claim 1 wherein: also comprises 4-6 parts of leveling agent KMT-5510S and 4-6 parts of defoaming agent BYK-A530.

7. The method for preparing the gun head of the high oleophobic pipette gun according to claim 1, which is characterized in that: (3) The heating temperature is 80-120 ℃, and the heating time is 0.5-1.5h.

8. The method for preparing the gun head of the high oleophobic pipette gun according to claim 1, which is characterized in that: (4) Wherein the heating temperature is 150-170 ℃ and the heating time is 0.5-1.5h.