CN115397991B - 用于颜色识别的光响应性蛋白及其应用 - Google Patents

用于颜色识别的光响应性蛋白及其应用 Download PDF

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CN115397991B
CN115397991B CN202180028549.XA CN202180028549A CN115397991B CN 115397991 B CN115397991 B CN 115397991B CN 202180028549 A CN202180028549 A CN 202180028549A CN 115397991 B CN115397991 B CN 115397991B
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protein
cells
amino acid
mutant
mutation
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CN115397991A (zh
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重村竣太
细岛颂子
角田聪
神取秀树
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Nagoya Institute of Technology NUC
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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CN202180028549.XA 2020-03-13 2021-03-15 用于颜色识别的光响应性蛋白及其应用 Active CN115397991B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020044713 2020-03-13
JP2020-044713 2020-03-13
PCT/JP2021/010440 WO2021182646A1 (ja) 2020-03-13 2021-03-15 色認識のための光応答性タンパク質及びその利用

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CN115397991A CN115397991A (zh) 2022-11-25
CN115397991B true CN115397991B (zh) 2024-09-20

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CN202180028549.XA Active CN115397991B (zh) 2020-03-13 2021-03-15 用于颜色识别的光响应性蛋白及其应用

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US (1) US20230104240A1 (https=)
EP (1) EP4119666A4 (https=)
JP (1) JP7723983B2 (https=)
CN (1) CN115397991B (https=)
WO (1) WO2021182646A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2020054868A1 (ja) * 2018-09-14 2021-08-30 国立大学法人 名古屋工業大学 光応答性タンパク質及びその利用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101484005A (zh) * 2006-05-04 2009-07-15 韦恩州立大学 通过向体内递送视紫红质核酸恢复视觉响应
KR101945962B1 (ko) * 2010-09-08 2019-02-08 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 돌연변이 채널로돕신 2
JPWO2020054868A1 (ja) * 2018-09-14 2021-08-30 国立大学法人 名古屋工業大学 光応答性タンパク質及びその利用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Molecular properties of a DTD channelrhodopsin from Guillardia theta;Yumeka等;Biophysics and Physicobiology;第14卷;57-66 *
Novel optogenetics tool: Gt_CCR4, a light-gated cation channel with high reactivity to weak light;Shoko等;Biophysical Reviews(第12期);453-459 *

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Publication number Publication date
JP7723983B2 (ja) 2025-08-15
CN115397991A (zh) 2022-11-25
EP4119666A1 (en) 2023-01-18
WO2021182646A1 (ja) 2021-09-16
US20230104240A1 (en) 2023-04-06
EP4119666A4 (en) 2024-04-03
JPWO2021182646A1 (https=) 2021-09-16

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