CN115389599B - 用于毛细管电泳的光学系统 - Google Patents

用于毛细管电泳的光学系统

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Publication number
CN115389599B
CN115389599B CN202211196912.1A CN202211196912A CN115389599B CN 115389599 B CN115389599 B CN 115389599B CN 202211196912 A CN202211196912 A CN 202211196912A CN 115389599 B CN115389599 B CN 115389599B
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China
Prior art keywords
capillaries
output beams
capillary
generate
collet
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CN202211196912.1A
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English (en)
Chinese (zh)
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CN115389599A (zh
Inventor
凯文·马赫尔
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Life Technologies Corp
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Life Technologies Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN202211196912.1A 2014-03-07 2015-03-06 用于毛细管电泳的光学系统 Active CN115389599B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201461949914P 2014-03-07 2014-03-07
US201461949961P 2014-03-07 2014-03-07
US61/949,961 2014-03-07
US61/949,914 2014-03-07
CN201580017012.8A CN106164665A (zh) 2014-03-07 2015-03-06 用于毛细管电泳的光学系统
PCT/US2015/019280 WO2015134925A1 (en) 2014-03-07 2015-03-06 Optical system for capillary electrophoresis

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580017012.8A Division CN106164665A (zh) 2014-03-07 2015-03-06 用于毛细管电泳的光学系统

Publications (2)

Publication Number Publication Date
CN115389599A CN115389599A (zh) 2022-11-25
CN115389599B true CN115389599B (zh) 2025-10-28

Family

ID=52737400

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202211196912.1A Active CN115389599B (zh) 2014-03-07 2015-03-06 用于毛细管电泳的光学系统
CN201580017012.8A Pending CN106164665A (zh) 2014-03-07 2015-03-06 用于毛细管电泳的光学系统

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201580017012.8A Pending CN106164665A (zh) 2014-03-07 2015-03-06 用于毛细管电泳的光学系统

Country Status (5)

Country Link
US (2) US11280759B2 (https=)
EP (2) EP4517318A3 (https=)
JP (1) JP6755188B2 (https=)
CN (2) CN115389599B (https=)
WO (1) WO2015134925A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115389599B (zh) * 2014-03-07 2025-10-28 生命技术公司 用于毛细管电泳的光学系统
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
CN107106983B (zh) 2014-10-22 2021-04-16 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
CN105548325B (zh) * 2016-01-30 2018-01-12 福州大学 毛细管电泳转轴式液滴进样装置及其进样方法
CN105973860B (zh) * 2016-06-29 2019-07-30 山东科立森生物股份有限公司 一种毛细管电泳检测系统及检测方法
CN105973859B (zh) * 2016-06-29 2019-01-29 山东科立森生物股份有限公司 一种毛细管电泳检测系统及检测方法
SG11201900782UA (en) 2016-08-15 2019-02-27 Univ Tasmania Inorganic ion detection system and methods
WO2018156969A1 (en) * 2017-02-24 2018-08-30 Life Technologies Corporation Optical systems and methods for sample separation
SG11201908837UA (en) * 2017-02-24 2019-10-30 Life Technologies Corp Capillary electrophoresis systems, related devices, and related methods
JP6685965B2 (ja) 2017-03-29 2020-04-22 株式会社日立ハイテク キャピラリ電気泳動装置および恒温槽
US10302295B2 (en) * 2017-10-18 2019-05-28 Rite-Hite Holding Corporation Illuminating fans for loading docks
US11222779B2 (en) * 2018-05-17 2022-01-11 GMJ Technologies, Inc. Apparatuses for optical and mass spectrometry detection
US11747300B2 (en) * 2018-09-03 2023-09-05 Hitachi High-Tech Corporation Capillary array unit
WO2020190969A1 (en) * 2019-03-18 2020-09-24 Life Technologies Corporation Multi-capillary optical detection system
US12209954B2 (en) 2019-08-07 2025-01-28 Life Technologies Corporation Multi-capillary optical detection system
JP7364798B2 (ja) * 2020-07-31 2023-10-18 株式会社日立ハイテク キャピラリ電気泳動装置
WO2022153571A1 (ja) * 2021-01-15 2022-07-21 エースバイオアナリシス株式会社 走査ユニット、システムおよび方法、ならびにマイクロカラム
US11733156B2 (en) * 2021-02-23 2023-08-22 Joseph R. Demers Semiconductor package for free-space coupling of radiation and method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614726A (en) * 1995-03-23 1997-03-25 Beckman Instruments, Inc. Automated optical alignment system and method using Raman scattering of capillary tube contents
EP1467202A2 (en) * 2003-04-11 2004-10-13 Hitachi High-Technologies Corporation Capillary electrophoresis apparatus

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3563140B2 (ja) * 1995-01-19 2004-09-08 株式会社日立製作所 キャピラリーアレイ電気泳動装置
US5439578A (en) * 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
US6017434A (en) 1995-05-09 2000-01-25 Curagen Corporation Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments
US6361672B1 (en) * 1996-06-10 2002-03-26 Transgenomic, Inc. Multiple laser diode electromagnetic radiation source in multiple electrophoresis channel systems
US6084667A (en) * 1997-03-12 2000-07-04 Nz Applied Technologies System and method for molecular sample measurement
FR2774472B1 (fr) * 1998-01-30 2000-04-21 Centre Nat Rech Scient Perfectionnements aux systemes d'electrophorese multicapillaire
JP2002540401A (ja) 1999-03-19 2002-11-26 ザ ガヴァナーズ オブ ザ ユニヴァーシティー オブ アルバータ 生物学的及びその他の試料の自動化２次元分析
US20050279949A1 (en) 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US6156178A (en) * 1999-07-13 2000-12-05 Molecular Dynamics, Inc. Increased throughput analysis of small compounds using multiple temporally spaced injections
JP3896739B2 (ja) * 1999-10-29 2007-03-22 株式会社日立製作所 キャピラリー電気泳動装置
US6690467B1 (en) * 2000-05-05 2004-02-10 Pe Corporation Optical system and method for optically analyzing light from a sample
JP4103302B2 (ja) * 2000-05-15 2008-06-18 株式会社日立製作所 キャピラリアレイを用いた電気泳動装置及びそれに用いられるサンプルプレートアセンブリ
WO2001090726A2 (en) * 2000-05-19 2001-11-29 Aclara Biosciences, Inc. Optical alignment in capillary detection using capillary wall scatter
JP2002228586A (ja) 2001-01-31 2002-08-14 Hitachi Ltd 蛍光測定装置及び蛍光測定方法
FR2827957B1 (fr) * 2001-07-25 2003-09-26 Picometrics Appareil de separation par electrophorese sur veine liquide et de detection par fluorescence induite par laser
US6870165B2 (en) * 2001-10-19 2005-03-22 Biocal Technology, Inc. Multi-color multiplexed analysis in a bio-separation system
US7189361B2 (en) * 2001-12-19 2007-03-13 3M Innovative Properties Company Analytical device with lightguide Illumination of capillary and microgrooves arrays
JP3562514B2 (ja) * 2002-02-08 2004-09-08 株式会社日立製作所 キャピラリーアレイ
JP4431421B2 (ja) 2003-04-11 2010-03-17 株式会社日立ハイテクノロジーズ キャピラリー電気泳動装置
US7298478B2 (en) * 2003-08-14 2007-11-20 Cytonome, Inc. Optical detector for a particle sorting system
US20060176481A1 (en) * 2005-02-10 2006-08-10 Massachusetts Institute Of Technology End-column fluorescence detection for capillary array electrophoresis
JP4616051B2 (ja) * 2005-04-05 2011-01-19 株式会社日立ハイテクノロジーズ 電気泳動装置、及び電気泳動方法
US7692783B2 (en) 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
CN101013083A (zh) * 2007-02-01 2007-08-08 大连理工大学 光纤嵌入式低电压驱动毛细管电泳芯片
CN101105455A (zh) * 2007-07-04 2008-01-16 四川大学 激光诱导荧光检测器
JP2009080070A (ja) * 2007-09-27 2009-04-16 Panasonic Corp 生体物質検出装置
US8975572B2 (en) * 2008-04-04 2015-03-10 Cvi Laser, Llc Compact, thermally stable fiber-optic array mountable to flow cell
JP2010078559A (ja) 2008-09-29 2010-04-08 Sumitomo Electric Ind Ltd 蛍光分析装置および方法
WO2010111231A1 (en) * 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US8357281B2 (en) * 2009-09-21 2013-01-22 Advanced Analytical Technologies, Inc. Multi-wavelength fluorescence detection system for multiplexed capillary electrophoresis
CN102023146A (zh) * 2010-09-28 2011-04-20 上海理工大学 一种光学检测的电泳芯片及其电泳装置
US20140049771A1 (en) * 2012-08-16 2014-02-20 Behrokh B. Sadri High-throughput multi laser wave mixing detection methods and apparatus
CN115389599B (zh) * 2014-03-07 2025-10-28 生命技术公司 用于毛细管电泳的光学系统

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614726A (en) * 1995-03-23 1997-03-25 Beckman Instruments, Inc. Automated optical alignment system and method using Raman scattering of capillary tube contents
EP1467202A2 (en) * 2003-04-11 2004-10-13 Hitachi High-Technologies Corporation Capillary electrophoresis apparatus

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Silvia Casado-Terrones 等.Simple luminescence detectors using a light-emitting diode or a Xe lamp, optical fiber and charge-coupled device, or photomultiplier for determining proteins in capillary electrophoresis: A critical comparison.《ANALYTICAL BIOCHEMISTRY》.2007,第365卷(第1期),第83-85页. *
Simple luminescence detectors using a light-emitting diode or a Xe lamp, optical fiber and charge-coupled device, or photomultiplier for determining proteins in capillary electrophoresis: A critical comparison;Silvia Casado-Terrones 等;《ANALYTICAL BIOCHEMISTRY》;20070223;第365卷(第1期);83-85 *

Also Published As

Publication number Publication date
US20170016853A1 (en) 2017-01-19
EP3114469B1 (en) 2024-11-20
EP4517318A2 (en) 2025-03-05
EP3114469A1 (en) 2017-01-11
US11280759B2 (en) 2022-03-22
CN115389599A (zh) 2022-11-25
JP6755188B2 (ja) 2020-09-16
CN106164665A (zh) 2016-11-23
JP2017507342A (ja) 2017-03-16
WO2015134925A1 (en) 2015-09-11
EP4517318A3 (en) 2025-03-26
US20220244218A1 (en) 2022-08-04

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