CN115380203A - 光学成像系统及应用所述光学成像系统的生化物质检测系统 - Google Patents

光学成像系统及应用所述光学成像系统的生化物质检测系统 Download PDF

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Publication number
CN115380203A
CN115380203A CN202080095539.3A CN202080095539A CN115380203A CN 115380203 A CN115380203 A CN 115380203A CN 202080095539 A CN202080095539 A CN 202080095539A CN 115380203 A CN115380203 A CN 115380203A
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lenses
imaging system
light
optical imaging
lens
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CN202080095539.3A
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姜鹤鸣
黄怡
邓茜
杨斌
温欣
曹明友
黄雁樵
伍子毅
克雷格·爱德华·乌里奇
布莱恩·基思·豪泽尔
颜景堂
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MGI Tech Co Ltd
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MGI Tech Co Ltd
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Publication of CN115380203A publication Critical patent/CN115380203A/zh
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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/02—Objectives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/0025—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 for optical correction, e.g. distorsion, aberration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)

Abstract

一种光学成像系统(1)，用于对样品进行拍照成像，光学成像系统(1)包括照明模块(11)与成像模块(15)，照明模块(11)用于输出激发光，激发光用于激发样品产生受激光，成像模块(15)包括时间延迟积分线阵相机(151)，时间延迟线阵相机(151)用于记录受激光。还提供一种应用光学成像系统(1)的生化物质检测系统，可提升检测通量。

Description

PCT国内申请，说明书已公开。

Claims (24)

  1. PCT国内申请，权利要求书已公开。
CN202080095539.3A 2020-02-12 2020-02-12 光学成像系统及应用所述光学成像系统的生化物质检测系统 Pending CN115380203A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2020/074795 WO2021159285A1 (zh) 2020-02-12 2020-02-12 光学成像系统及应用所述光学成像系统的生化物质检测系统

Publications (1)

Publication Number Publication Date
CN115380203A true CN115380203A (zh) 2022-11-22

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CN202080095539.3A Pending CN115380203A (zh) 2020-02-12 2020-02-12 光学成像系统及应用所述光学成像系统的生化物质检测系统

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US (1) US20230092006A1 (zh)
EP (1) EP4105642A4 (zh)
JP (1) JP2023513729A (zh)
CN (1) CN115380203A (zh)
WO (1) WO2021159285A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115452783B (zh) * 2022-08-22 2023-12-22 深圳赛陆医疗科技有限公司 检测装置及基因测序仪
CN116718578B (zh) * 2023-08-11 2023-10-27 深圳赛陆医疗科技有限公司 超分辨显微成像系统和成像方法

Citations (7)

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JP2006003542A (ja) * 2004-06-16 2006-01-05 Olympus Corp 所望の観察部位への合焦精度を高めたアクティブオートフォーカス方法、システムおよびこれらを用いた顕微鏡装置
JP2014032329A (ja) * 2012-08-03 2014-02-20 Ricoh Opt Ind Co Ltd 投射用ズームレンズおよび投射型画像表示装置および撮像装置
CN203759351U (zh) * 2014-03-11 2014-08-06 宁波舜宇仪器有限公司 显微镜物镜
CN104199176A (zh) * 2014-09-19 2014-12-10 湖南文理学院 一种用于监控系统的超大视场镜头
CN104967759A (zh) * 2015-02-13 2015-10-07 华中科技大学 一种用于弱光信号的扫描成像系统
CN105039147A (zh) * 2015-06-03 2015-11-11 西安交通大学 一种高通量基因测序碱基荧光图像捕获系统装置及方法
CN110657953A (zh) * 2018-06-29 2020-01-07 上海微电子装备（集团）股份有限公司 焦距测量系统和方法、调焦系统和方法以及光刻装置

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JP2010117705A (ja) * 2008-10-14 2010-05-27 Olympus Corp バーチャルスライド作成システム用顕微鏡
US8923568B2 (en) * 2011-07-13 2014-12-30 Leica Biosystems Imaging, Inc. Standardizing fluorescence microscopy systems
CA2902356A1 (en) * 2013-02-25 2014-08-28 Huron Technologies International Inc. Microscopy slide scanner with variable magnification
JP2014182034A (ja) * 2013-03-19 2014-09-29 Toray Eng Co Ltd 蛍光画像観察装置
CN104535481B (zh) * 2014-12-29 2017-04-05 中国科学院长春光学精密机械与物理研究所 成像流式细胞仪
CN106645045B (zh) * 2016-09-09 2020-01-21 华中科技大学 一种荧光光学显微成像中基于tdi-ccd的双向扫描成像方法
WO2018207833A1 (ja) * 2017-05-11 2018-11-15 株式会社ニコン 対物レンズ、光学系および顕微鏡

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006003542A (ja) * 2004-06-16 2006-01-05 Olympus Corp 所望の観察部位への合焦精度を高めたアクティブオートフォーカス方法、システムおよびこれらを用いた顕微鏡装置
JP2014032329A (ja) * 2012-08-03 2014-02-20 Ricoh Opt Ind Co Ltd 投射用ズームレンズおよび投射型画像表示装置および撮像装置
CN203759351U (zh) * 2014-03-11 2014-08-06 宁波舜宇仪器有限公司 显微镜物镜
CN104199176A (zh) * 2014-09-19 2014-12-10 湖南文理学院 一种用于监控系统的超大视场镜头
CN104967759A (zh) * 2015-02-13 2015-10-07 华中科技大学 一种用于弱光信号的扫描成像系统
CN105039147A (zh) * 2015-06-03 2015-11-11 西安交通大学 一种高通量基因测序碱基荧光图像捕获系统装置及方法
CN110657953A (zh) * 2018-06-29 2020-01-07 上海微电子装备（集团）股份有限公司 焦距测量系统和方法、调焦系统和方法以及光刻装置

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Publication number Publication date
WO2021159285A1 (zh) 2021-08-19
EP4105642A1 (en) 2022-12-21
JP2023513729A (ja) 2023-04-03
US20230092006A1 (en) 2023-03-23
EP4105642A4 (en) 2023-11-29

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