CN115380024A - 二氮杂螺吡喃化合物的晶型 - Google Patents
二氮杂螺吡喃化合物的晶型 Download PDFInfo
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- CN115380024A CN115380024A CN202180025961.6A CN202180025961A CN115380024A CN 115380024 A CN115380024 A CN 115380024A CN 202180025961 A CN202180025961 A CN 202180025961A CN 115380024 A CN115380024 A CN 115380024A
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract
一类二氮杂螺吡喃化合物的盐型、晶型(I)及其制备方法，还包括所述盐型和晶型在制备治疗相关疾病药物中的应用。
Description
PCT国内申请，说明书已公开。
Claims (50)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010239276 | 2020-03-30 | ||
| CN2020102392760 | 2020-03-30 | ||
| CN202010251233 | 2020-04-01 | ||
| CN2020102512334 | 2020-04-01 | ||
| PCT/CN2021/084092 WO2021197344A1 (zh) | 2020-03-30 | 2021-03-30 | 二氮杂螺吡喃化合物的晶型 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115380024A true CN115380024A (zh) | 2022-11-22 |
| CN115380024B CN115380024B (zh) | 2024-03-15 |
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| CN202180025961.6A Active CN115380024B (zh) | 2020-03-30 | 2021-03-30 | 二氮杂螺吡喃化合物的晶型 |
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| Country | Link |
|---|---|
| US (1) | US20230141887A1 (zh) |
| CN (1) | CN115380024B (zh) |
| WO (1) | WO2021197344A1 (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012053606A1 (ja) * | 2010-10-22 | 2012-04-26 | アステラス製薬株式会社 | アリールアミノヘテロ環カルボキサミド化合物 |
| CN112839930A (zh) * | 2018-09-30 | 2021-05-25 | 南京明德新药研发有限公司 | 作为flt3和axl抑制剂的3,9-二氮杂螺[5, 5]十一烷类化合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011011875A (es) * | 2009-05-08 | 2011-12-08 | Astellas Pharma Inc | Compuesto de carboxamida heterociclica diamino. |
-
2021
- 2021-03-30 US US17/907,607 patent/US20230141887A1/en active Pending
- 2021-03-30 CN CN202180025961.6A patent/CN115380024B/zh active Active
- 2021-03-30 WO PCT/CN2021/084092 patent/WO2021197344A1/zh active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012053606A1 (ja) * | 2010-10-22 | 2012-04-26 | アステラス製薬株式会社 | アリールアミノヘテロ環カルボキサミド化合物 |
| CN112839930A (zh) * | 2018-09-30 | 2021-05-25 | 南京明德新药研发有限公司 | 作为flt3和axl抑制剂的3,9-二氮杂螺[5, 5]十一烷类化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20230141887A1 (en) | 2023-05-11 |
| CN115380024B (zh) | 2024-03-15 |
| WO2021197344A1 (zh) | 2021-10-07 |
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