CN115350393A - Preparation method of pyramid-shaped drug-loaded microneedle array - Google Patents
Preparation method of pyramid-shaped drug-loaded microneedle array Download PDFInfo
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- CN115350393A CN115350393A CN202211011900.7A CN202211011900A CN115350393A CN 115350393 A CN115350393 A CN 115350393A CN 202211011900 A CN202211011900 A CN 202211011900A CN 115350393 A CN115350393 A CN 115350393A
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- tool electrode
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- microneedle array
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- 239000003814 drug Substances 0.000 title claims abstract description 24
- 229940079593 drug Drugs 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 238000003754 machining Methods 0.000 claims abstract description 23
- 239000003792 electrolyte Substances 0.000 claims abstract description 16
- 230000033001 locomotion Effects 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- 230000007797 corrosion Effects 0.000 claims description 4
- 238000005260 corrosion Methods 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 230000009471 action Effects 0.000 claims description 3
- 230000005484 gravity Effects 0.000 claims description 3
- 239000007769 metal material Substances 0.000 claims description 3
- 239000012266 salt solution Substances 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 description 9
- 238000012377 drug delivery Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000013271 transdermal drug delivery Methods 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 230000037317 transdermal delivery Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25F—PROCESSES FOR THE ELECTROLYTIC REMOVAL OF MATERIALS FROM OBJECTS; APPARATUS THEREFOR
- C25F3/00—Electrolytic etching or polishing
- C25F3/02—Etching
- C25F3/14—Etching locally
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
Abstract
The invention discloses a preparation method of a pyramid-shaped drug-loaded microneedle array, which relates to the technical field of medical equipment preparation and comprises the following steps: adding electrolyte into the solution tank, and enabling the electrolyte to immerse a mesh type tool electrode arranged in the solution tank; mounting a workpiece on the fixture, and enabling the workpiece to be positioned above a mesh-type tool electrode, wherein the workpiece is connected with a positive electrode of a power supply, and the mesh-type tool electrode is connected with a negative electrode of the power supply; driving the clamp to drive the workpiece to feed downwards along the Z-axis at a certain speed; the mesh type tool electrode is driven to simultaneously reciprocate in the X-axis and Y-axis directions to realize the electrolytic machining of the drug-loaded microneedle array on the workpiece.
Description
Technical Field
The invention relates to the technical field of medical equipment preparation, in particular to a preparation method of a pyramid-shaped drug-loaded microneedle array.
Background
With the development of science and technology, microneedles have received wide attention as a transdermal drug delivery technology in the fields of medical treatment, beauty treatment and the like. Compared with the traditional transdermal delivery mode, the micro-needle can generate micro-channels through the epidermal layer to deliver the medicine to the subcutaneous part. The microneedle transdermal drug delivery technology integrates the advantages of subcutaneous injection drug delivery and transdermal patch drug delivery, has the advantages of high transmission speed, accurate drug delivery, high drug absorption efficiency, minimal invasion, almost no wound and no pain, and effectively overcomes the defect that the traditional transdermal drug delivery patch is difficult to realize macromolecular drug delivery. In addition, the patient can self-administer the medicine, which is convenient and fast and saves social medical resources, and the microneedle transdermal administration technology has huge application prospect in the aspects of tumor, anesthesia, dentistry and the like.
Before the microneedle transdermal delivery technology is applied, a microneedle array meeting the requirements needs to be designed and developed according to skin diseases or skin symptoms. By means of the breakthrough of micro electromechanical system and ultra-precise machining technology, conical or pyramidal micro needles are gradually favored, wherein the metal micro needles have good mechanical property, high durability and higher practical value. However, the preparation of the pyramidal metal microneedle is a precise and complicated process, and if the surface processing quality does not meet the required requirements, the processed burr easily causes a foreign body feeling to the skin. In terms of the current processing technology, the processing technology of the microneedles is generally high in cost, the processing quality is not easy to guarantee, mass production is not easy to realize, the mechanical processing mode needs to perform deburring on the microneedles subsequently, and the processing technology is complex. Therefore, a method for preparing a pyramid-shaped drug-loaded microneedle array is needed to solve the above problems.
Disclosure of Invention
The invention aims to provide a preparation method of a pyramid-shaped drug-loaded microneedle array, which aims to solve the problems in the prior art proposed in the background art.
In order to achieve the purpose, the invention provides the following technical scheme:
a preparation method of a pyramid-shaped drug-loaded microneedle array comprises the following steps:
s1: adding electrolyte into the solution tank, and enabling the electrolyte to immerse a mesh type tool electrode arranged in the solution tank;
s2: mounting a workpiece on the fixture, and enabling the workpiece to be positioned above a mesh-type tool electrode, wherein the workpiece is connected with a positive electrode of a power supply, and the mesh-type tool electrode is connected with a negative electrode of the power supply;
s3: driving the clamp to drive the workpiece to feed downwards along the Z-axis at a certain speed;
s4: and driving the mesh type tool electrode to reciprocate in the X-axis and Y-axis directions simultaneously to realize the electrolytic machining of the drug-loaded microneedle array on the workpiece.
Preferably, the mesh-type tool electrode has a shape corresponding to the pyramid-shaped microneedles, and the reciprocating distances of the mesh-type tool electrode along the X axis and the Y axis are corrected according to the shape and the size of the microneedles, so that the motion profile of the mesh-type tool electrode is matched with the shape of the microneedles.
Preferably, the reciprocating motion of the mesh-type tool electrode drives the electrolyte to flow, so that the electrolytic machining product is accelerated to be discharged from the machining area under the action of gravity.
Preferably, the reciprocating motion of the mesh-type tool electrode enables bubbles to reciprocate reversely, so that stable and continuous electrolytic machining is guaranteed, and stray corrosion of a non-machined area is weakened by the bubbles.
Preferably, the workpiece is a metal material.
Preferably, the electrolyte is a salt solution or an acid solution.
Compared with the prior art, the invention has the beneficial effects that:
1. the preparation method of the pyramid-shaped drug-loaded microneedle array provided by the invention realizes one-time molding of the microneedle array, eliminates the deburring procedure of the microneedle array, improves the processing efficiency of the microneedles, reduces the production cost and saves the production data.
2. The invention accelerates the discharge speed of the electrolytic machining product, weakens the influence of the electrolytic machining product on the electric field distribution and improves the machining quality of the surface of the workpiece by a machining mode from bottom to top.
3. The invention eliminates the blocking effect of the bubbles on the processing in a reciprocating motion mode, realizes the reduction of stray corrosion by the bubbles, and improves the size and shape precision of the microneedle array.
Drawings
Fig. 1 is a schematic view of an implementation of the preparation method of the pyramid-shaped drug-loaded microneedle array of the present invention.
FIG. 2 is a schematic view of the position of the workpiece and the mesh tool electrode of the present invention.
Fig. 3 is a schematic workpiece form diagram of a pyramid-shaped drug-loaded microneedle array according to the present invention.
Fig. 4 is a schematic diagram of the movement of bubbles in the preparation process of the pyramid-shaped drug-loaded microneedle array of the present invention.
Fig. 5 is a schematic diagram of a pyramid drug-loaded microneedle array of different forms prepared and molded according to the present invention.
In the figure: 1. a solution tank; 2. an electrolyte; 3. a clamp; 4. a workpiece; 5. a mesh-type tool electrode; 6. electrolytically processing the product; 7. air bubbles.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Referring to fig. 1-5, the present invention provides a technical solution:
a preparation method of a pyramid-shaped drug-loaded microneedle array comprises the following steps:
adding electrolyte 2 into the solution tank 1, and enabling the electrolyte 2 to immerse a mesh type tool electrode 5 arranged in the solution tank 1; the mesh type tool electrode 5 has a shape corresponding to a pyramid-shaped microneedle, the reciprocating movement distance of the mesh type tool electrode 5 along the X axis and the Y axis is corrected according to the shape and the size of the microneedle, so that the movement profile of the mesh type tool electrode is matched with the shape of the microneedle, and the drug-carrying microneedle array with various structural shapes can be prepared by the preparation method.
Mounting the workpiece 4 on the clamp 3, and enabling the workpiece 4 to be positioned above the mesh type tool electrode 5, wherein the workpiece 4 is connected with a positive electrode of a power supply, and the mesh type tool electrode 5 is connected with a negative electrode of the power supply; driving the clamp 3 to drive the workpiece 4 to feed downwards along the Z-axis at a certain speed; driving the mesh type tool electrode 5 to reciprocate in the X-axis and Y-axis directions simultaneously; in the process of preparing the pyramid drug-carrying microneedle array by electrolysis, the mesh type tool electrode 5 reciprocates simultaneously along the X axis and the Y axis, the reciprocating distance of the X axis and the Y axis is automatically controlled according to the shape and the size of the microneedles, and meanwhile, the workpiece 4 is fed downwards at a constant speed along the Z axis, so that the electrochemical machining of the drug-carrying microneedle array on the workpiece 4 is realized.
The reciprocating motion of the mesh type tool electrode 5 drives the electrolyte 2 to flow, so that the electrolytic machining product 6 is accelerated to be discharged from the machining area under the action of gravity, the electrolytic machining environment of the microneedle array is improved, the influence of the machining product on the electric field distribution is reduced, and the machining stability and the surface machining quality are improved.
The reciprocating motion of the mesh type tool electrode 5 enables the bubbles 7 to reciprocate reversely, so that the electrolytic machining is ensured to be stably and continuously carried out, and the stray corrosion of a non-machined area is weakened by the bubbles 7, so that the machining locality is improved, and the size and shape precision are improved; the workpiece 4 is made of a metal material, such as a stainless steel material; the electrolyte 2 is a salt solution or an acid solution, for example, a sodium chloride solution is used as the electrolyte 2.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The preparation method of the pyramid-shaped drug-loaded microneedle array is characterized by comprising the following steps of:
s1: adding electrolyte (2) into the solution tank (1), and enabling the electrolyte (2) to immerse a mesh type tool electrode (5) arranged in the solution tank (1);
s2: mounting the workpiece (4) on the clamp (3) and enabling the workpiece (4) to be positioned above the mesh type tool electrode (5), wherein the workpiece (4) is connected with a positive electrode of a power supply, and the mesh type tool electrode (5) is connected with a negative electrode of the power supply;
s3: the clamp (3) is driven to drive the workpiece (4) to feed downwards along the Z-axis at a certain speed;
s4: and driving the mesh type tool electrode (5) to reciprocate in the X-axis and Y-axis directions simultaneously to realize the electrolytic machining of the micro-needle array loaded on the workpiece (4).
2. The method for preparing a pyramid-shaped drug-loaded microneedle array according to claim 1, wherein: the mesh type tool electrode (5) is in a shape corresponding to the pyramid-shaped micro-needle, and the reciprocating distance of the mesh type tool electrode (5) along the X axis and the Y axis is corrected according to the shape and the size of the micro-needle, so that the motion profile of the mesh type tool electrode is matched with the shape of the micro-needle.
3. The method for preparing a pyramid-shaped drug-loaded microneedle array according to claim 2, wherein: the reciprocating motion of the mesh type tool electrode (5) drives the electrolyte (2) to flow, so that the electrolytic machining product (6) is accelerated to be discharged from the machining area under the action of gravity.
4. The method for preparing a pyramid-shaped drug-loaded microneedle array according to claim 1, wherein: the reciprocating motion of the mesh type tool electrode (5) enables the bubbles (7) to reciprocate reversely, so that the electrolytic machining is ensured to be stably and continuously carried out, and the bubbles (7) are utilized to weaken the stray corrosion of a non-machined area.
5. The method for preparing a drug-loaded pyramid microneedle array according to claim 1, wherein: the workpiece (4) is made of a metal material.
6. The method for preparing a drug-loaded pyramid microneedle array according to claim 2, wherein: the electrolyte (2) is a salt solution or an acid solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211011900.7A CN115350393A (en) | 2022-08-23 | 2022-08-23 | Preparation method of pyramid-shaped drug-loaded microneedle array |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211011900.7A CN115350393A (en) | 2022-08-23 | 2022-08-23 | Preparation method of pyramid-shaped drug-loaded microneedle array |
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| CN115350393A true CN115350393A (en) | 2022-11-18 |
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| CN202211011900.7A Pending CN115350393A (en) | 2022-08-23 | 2022-08-23 | Preparation method of pyramid-shaped drug-loaded microneedle array |
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085483A (en) * | 2007-06-22 | 2007-12-12 | 哈尔滨工业大学 | Combinational processing method for micro-array axle hole |
| JP2009228041A (en) * | 2008-03-21 | 2009-10-08 | Kurita Water Ind Ltd | Electrolytic apparatus and electrolytic method |
| CN103056463A (en) * | 2012-12-17 | 2013-04-24 | 南京航空航天大学 | Manufacturing method for carbon nano tube tool electrode for micro electrochemical machining and multi-functional working tanks |
| CN104511669A (en) * | 2013-09-29 | 2015-04-15 | 浙江工业大学 | Electrochemical machining method of disc array group electrodes with large length-to-diameter ratio |
| CN107498124A (en) * | 2017-08-21 | 2017-12-22 | 广东工业大学 | A kind of device of Electrolyzed Processing plane complications group's groove |
| CN107695467A (en) * | 2017-11-20 | 2018-02-16 | 浙江工业大学 | A kind of pressure type circulating jet Electrolyzed Processing micro-electrode array preparation method and device |
| US20190055144A1 (en) * | 2016-03-30 | 2019-02-21 | Panasonic Intellectual Property Management Co., Ltd. | Electrolytic liquid generation device |
| CN113332588A (en) * | 2021-05-26 | 2021-09-03 | 四川大学 | Tip drug-loading soluble microneedle patch for oral mucosa drug delivery and preparation method thereof |
| WO2021216186A2 (en) * | 2020-02-21 | 2021-10-28 | The Regents Of The University Of California | Microneedle array sensor patch for continuous multi-analyte detection |
-
2022
- 2022-08-23 CN CN202211011900.7A patent/CN115350393A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085483A (en) * | 2007-06-22 | 2007-12-12 | 哈尔滨工业大学 | Combinational processing method for micro-array axle hole |
| JP2009228041A (en) * | 2008-03-21 | 2009-10-08 | Kurita Water Ind Ltd | Electrolytic apparatus and electrolytic method |
| CN103056463A (en) * | 2012-12-17 | 2013-04-24 | 南京航空航天大学 | Manufacturing method for carbon nano tube tool electrode for micro electrochemical machining and multi-functional working tanks |
| CN104511669A (en) * | 2013-09-29 | 2015-04-15 | 浙江工业大学 | Electrochemical machining method of disc array group electrodes with large length-to-diameter ratio |
| US20190055144A1 (en) * | 2016-03-30 | 2019-02-21 | Panasonic Intellectual Property Management Co., Ltd. | Electrolytic liquid generation device |
| CN107498124A (en) * | 2017-08-21 | 2017-12-22 | 广东工业大学 | A kind of device of Electrolyzed Processing plane complications group's groove |
| CN107695467A (en) * | 2017-11-20 | 2018-02-16 | 浙江工业大学 | A kind of pressure type circulating jet Electrolyzed Processing micro-electrode array preparation method and device |
| WO2021216186A2 (en) * | 2020-02-21 | 2021-10-28 | The Regents Of The University Of California | Microneedle array sensor patch for continuous multi-analyte detection |
| CN113332588A (en) * | 2021-05-26 | 2021-09-03 | 四川大学 | Tip drug-loading soluble microneedle patch for oral mucosa drug delivery and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 吴修娟: "微纳电解加工基础研究", 中国博士学位论文全文数据库, no. 01, pages 5 * |
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Application publication date: 20221118 |