CN115337377A - Traditional Chinese medicine formula for reducing blood fat and preparation method thereof - Google Patents
Traditional Chinese medicine formula for reducing blood fat and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine formula for reducing blood fat and a preparation method thereof, wherein the traditional Chinese medicine formula is prepared from the following raw materials in parts by weight: 20 to 30 parts of samara oil, 10 to 15 parts of turmeric, 5 to 6 parts of dried orange peel, 15 to 20 parts of hawthorn, 15 to 20 parts of uniflower swisscentaury root, 15 to 20 parts of kudzuvine root, 10 to 20 parts of salvia miltiorrhiza and 5 to 10 parts of oriental waterplantain rhizome. The formula of the invention has no additive, and can effectively reduce Triglyceride (TG), total Cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and Arteriosclerosis Index (AI), thereby achieving the purpose of quickly reducing blood fat and having obvious curative effect.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine formula for reducing blood fat and a preparation method thereof.
Background
Hyperlipidemia, i.e., elevated serum total cholesterol, triglycerides, low density lipoproteins, is a major cause of cardiovascular and cerebrovascular diseases. A large number of epidemiological surveys and researches show that hyperlipidemia is an important risk factor for Atherosclerosis (AS), coronary Heart Disease (CHD), hypertension, diabetes, cholelithiasis and other diseases, and seriously harms human health.
At present, the traditional Chinese medicine has more reports on treating hyperlipemia, and has different syndrome differentiation and different formulas according to different causes and pathogenesis. Patent CN201910092968.4 discloses a traditional Chinese medicine composition for reducing blood fat and softening blood vessels, which is composed of the following raw materials in parts by weight: 25 parts of cassia seed, 75 parts of lotus leaf, 25 parts of prepared fleece-flower root and 500 parts of pitted hawthorn. Patent CN201010536580.8 discloses a blood fat reducing traditional Chinese medicine composition, which is composed of the following raw material medicines in parts by weight: 60-104 parts of rhizoma alismatis, 56-100 parts of grape seeds, 49-88 parts of glossy privet fruit, 33-66 parts of gynostemma pentaphylla, 33-66 parts of turmeric, 30-61 parts of sea buckthorn and 12-34 parts of green tea. Patent CN200910236322 discloses a composition with auxiliary blood lipid lowering function, which is composed of red yeast rice, ginkgo leaf extract, prepared fleece-flower root extract and alisma orientale extract.
How to more reasonably apply the theory of traditional Chinese medicine and find a new formula with few kinds of medicinal materials, precise dosage and proportion and remarkable curative effect is the current direction of effort of traditional Chinese medicine workers.
The samara oil tree (Elaeagnus nummollis) is a standing arbor or shrub of Elaeagnus, with the kernel containing crude fat 46.58-51.4 s% and oil yield up to 30-35%. The samara oil contains linoleic acid up to 45.2%, which can reduce the content of cholesterol and triglyceride in blood, maintain the balance of blood fat metabolism, prevent the deposition of cholesterol on the blood vessel wall, and enhance the toughness of the blood vessel wall, thereby preventing and treating diseases such as hypertension, hyperlipidemia, angiosclerosis, etc.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine formula for reducing blood fat and a preparation method thereof, which can effectively reduce Triglyceride (TG), total Cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and Arteriosclerosis Index (AI) and have obvious curative effect.
In order to achieve the purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine formula for reducing blood fat is prepared from the following raw materials in parts by weight:
20 to 30 parts of samara oil, 10 to 15 parts of turmeric, 5 to 6 parts of dried orange peel, 15 to 20 parts of hawthorn, 15 to 20 parts of uniflower swisscentaury root, 15 to 20 parts of kudzuvine root, 10 to 20 parts of salvia miltiorrhiza and 5 to 10 parts of oriental waterplantain rhizome.
As a preferable design of the scheme, the paint is prepared from the following raw materials in parts by weight:
20 parts of samara oil, 10 parts of turmeric, 5 parts of dried orange peel, 15 parts of hawthorn, 15 parts of uniflower swisscentaury root, 15 parts of kudzuvine root, 5 parts of oriental waterplantain rhizome and 10 parts of salvia miltiorrhiza.
As a preferable design of the scheme, the paint is prepared from the following raw materials in parts by weight:
30 parts of samara oil, 15 parts of turmeric, 6 parts of dried orange peel, 20 parts of hawthorn, 20 parts of uniflower swisscentaury root, 20 parts of kudzuvine root, 20 parts of salvia miltiorrhiza and 10 parts of oriental waterplantain rhizome.
As a preferable design of the scheme, the paint is prepared from the following raw materials in parts by weight:
25 parts of samara oil, 12.5 parts of turmeric, 5.5 parts of dried orange peel, 17.5 parts of hawthorn, 17.5 parts of uniflower swisscentaury root, 17.5 parts of kudzu root, 15 parts of salvia miltiorrhiza and 7.5 parts of rhizoma alismatis.
The invention also provides a preparation method of the traditional Chinese medicine formula for reducing blood fat, which comprises the following steps:
s1, weighing the components according to a formula;
s2, crushing turmeric, dried orange peel, hawthorn, uniflower swisscentaury root, kudzuvine root, red-rooted salvia root and oriental waterplantain rhizome into fine powder, and sieving the fine powder with a 200-mesh sieve for later use;
s3, placing the obtained fine powder in a frying pan, adding 6 times of distilled water, soaking until the fine powder is thoroughly soaked, decocting for 45min, filtering, keeping the filtrate for later use, adding 80 vol% ethanol solution into filter residues, performing 500w ultrasonic extraction for 30min, filtering, combining the filtrates, concentrating, recovering the solvent, and drying into powder;
and S4, mixing the obtained powder with the samara oil, adding a pharmaceutically acceptable carrier and/or excipient, and preparing the mixture into capsules by adopting a traditional preparation process.
The formula of the invention has no additive, 8 medicines have the effects of removing blood stasis, dredging collaterals, eliminating phlegm and discharging turbidity, and can effectively reduce Triglyceride (TG), total Cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and Arteriosclerosis Index (AI), thereby achieving the purpose of quickly reducing blood fat and having obvious curative effect.
Detailed Description
In order to make the objects and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following examples. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
A traditional Chinese medicine formula for reducing blood fat is prepared from the following raw materials in parts by weight:
20 parts of samara oil, 10 parts of turmeric, 5 parts of dried orange peel, 15 parts of hawthorn, 15 parts of uniflower swisscentaury root, 15 parts of kudzuvine root, 5 parts of oriental waterplantain rhizome and 10 parts of salvia miltiorrhiza.
Example 2
A traditional Chinese medicine formula for reducing blood fat is prepared from the following raw materials in parts by weight:
30 parts of samara oil, 15 parts of turmeric, 6 parts of dried orange peel, 20 parts of hawthorn, 20 parts of uniflower swisscentaury root, 20 parts of kudzuvine root, 20 parts of salvia miltiorrhiza and 10 parts of oriental waterplantain rhizome.
Example 3
A traditional Chinese medicine formula for reducing blood fat is prepared from the following raw materials in parts by weight:
25 parts of samara oil, 12.5 parts of turmeric, 5.5 parts of dried orange peel, 17.5 parts of hawthorn, 17.5 parts of uniflower swisscentaury root, 17.5 parts of kudzu root, 15 parts of salvia miltiorrhiza and 7.5 parts of rhizoma alismatis.
The preparation method comprises the following steps:
pulverizing Curcuma rhizome, pericarpium Citri Tangerinae, fructus crataegi, radix Rhapontici, radix Puerariae, saviae Miltiorrhizae radix, and Alismatis rhizoma into fine powder, and sieving with 200 mesh sieve;
placing the obtained fine powder in a frying pan, adding 6 times of distilled water, soaking until it is thoroughly soaked, decocting for 45min, filtering, collecting filtrate, adding 80% ethanol solution into the residue, performing 500w ultrasonic extraction for 30min, filtering, mixing filtrates, concentrating, recovering solvent, and drying to obtain powder;
mixing the obtained powder with oleum pteridis Pilosae, adding pharmaceutically acceptable carrier and/or excipient, and making into capsule by conventional method.
Test materials
Materials and animals:
1. and (3) testing a sample: the Chinese medicinal formulae obtained in example 1, example 2 and example 3.
2. Test animals: wistar rat 90, each half male and female, weight 180 ~ 220g.
3. The method comprises the following steps: blood is collected from 100 Wistar rats after adaptation for 7 days in a laboratory, the blood fat is measured, and 90 rats with the blood fat meeting the test requirements are screened out and randomly divided into 6 groups and 15 rats/group. Blank control group, high fat model group, positive control group, example 1 group, example 2 group and example 3 group, respectively. Continuously feeding for 40 days, freely taking basic feed in blank group, and intragastrically administering 2ml/200g with normal saline every day; the high-fat model group freely takes high-fat feed, and the normal saline is infused into the stomach for 2ml/200g every day; the positive control group takes high-fat feed freely and perfuses the stomach with 0.2mg/200g of simvastatin every day; the groups of example 1, example 2 and example 3 were fed with free high-fat diet, and the Chinese medicinal composition was administered daily by gavage at a dose of 0.2g/200g. Wherein, the high fat feed contains 2 percent of cholesterol, 10 percent of lard, 0.5 percent of sodium cholate and 87.5 percent of basal feed.
After fasting for 16 hours before the end of the experiment, orbital plexus was sampled, centrifuged, and serum was prepared and values of TC (total cholesterol), TG (triglyceride), high-density lipoprotein (LDH-C), and low-density lipoprotein (LDL-C) were measured according to the kit instructions.
4. The statistical method comprises the following steps: mean ± sd for data
Showing that two independent samples t test of SPSS13.0 For Windows are used For statistical processing, P<0.05 is a significant difference.
5. The experimental results are as follows: the TC and TG values in the serum of the model control group are obviously increased compared with those of a blank control group (P is less than 0.05); the TC and TG of the administration group and the positive control group are obviously reduced compared with the model control group (P < 0.05). See table 1 for details.
TABLE 1 rat serum TC (total cholesterol), TG (triglyceride), high-density lipoprotein (LDH-C), low-density lipoprotein (LDL-C) (mmol/L,
)
meanwhile, experiments show that the traditional Chinese medicine formula can inhibit the transcription of PCSK9 and ANGPTL3 at the same time, and is a promising blood fat reducing medicine.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that those skilled in the art can make various improvements and modifications without departing from the principle of the present invention, and these improvements and modifications should also be construed as the protection scope of the present invention.
Claims (5)
1. The traditional Chinese medicine formula for reducing blood fat is characterized by being prepared from the following raw materials in parts by weight:
20 to 30 parts of samara oil, 10 to 15 parts of turmeric, 5 to 6 parts of dried orange peel, 15 to 20 parts of hawthorn, 15 to 20 parts of uniflower swisscentaury root, 15 to 20 parts of kudzuvine root, 10 to 20 parts of salvia miltiorrhiza and 5 to 10 parts of oriental waterplantain rhizome.
2. The traditional Chinese medicine formula for reducing blood fat according to claim 1, which is prepared from the following raw materials in parts by weight:
20 parts of samara oil, 10 parts of turmeric, 5 parts of dried orange peel, 15 parts of hawthorn, 15 parts of uniflower swisscentaury root, 15 parts of kudzuvine root, 5 parts of oriental waterplantain rhizome and 10 parts of salvia miltiorrhiza.
3. The traditional Chinese medicine formula for reducing blood fat according to claim 1, which is prepared from the following raw materials in parts by weight:
30 parts of samara oil, 15 parts of turmeric, 6 parts of dried orange peel, 20 parts of hawthorn, 20 parts of uniflower swisscentaury root, 20 parts of kudzuvine root, 20 parts of salvia miltiorrhiza and 10 parts of oriental waterplantain rhizome.
4. The traditional Chinese medicine formula for reducing blood fat according to claim 1, which is prepared from the following raw materials in parts by weight:
25 parts of samara oil, 12.5 parts of turmeric, 5.5 parts of dried orange peel, 17.5 parts of hawthorn, 17.5 parts of uniflower swisscentaury root, 17.5 parts of kudzuvine root, 15 parts of salvia miltiorrhiza and 7.5 parts of oriental waterplantain rhizome.
5. The preparation method of the traditional Chinese medicine formula for reducing blood fat according to any one of claims 1 to 4, which is characterized in that: the method comprises the following steps:
s1, weighing the components according to a formula;
s2, crushing turmeric, dried orange peel, hawthorn, uniflower swisscentaury root, kudzuvine root, red-rooted salvia root and oriental waterplantain rhizome into fine powder, and sieving the fine powder with a 200-mesh sieve for later use;
s3, placing the obtained fine powder in a frying pan, adding 6 times of distilled water, soaking until the fine powder is thoroughly soaked, decocting for 45min, filtering, keeping the filtrate for later use, adding 80% ethanol solution into filter residues, performing 500w ultrasonic extraction for 30min, filtering, combining the filtrates, concentrating, recovering the solvent, and drying into powder;
and S4, mixing the obtained powder with the samara oil, adding a pharmaceutically acceptable carrier and/or excipient, and preparing the mixture into capsules by adopting a traditional preparation process.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999020289A1 (en) * | 1997-10-22 | 1999-04-29 | R.P. Scherer Holdings Pty. Ltd. | Clear herbal extract solutions |
| CN104491751A (en) * | 2015-01-09 | 2015-04-08 | 王深涧 | Traditional Chinese medicine composition for treating fatty liver combined with hyperlipidemia and preparation method of traditional Chinese medicine composition |
| CN104855979A (en) * | 2015-04-22 | 2015-08-26 | 劲膳美生物科技股份有限公司 | Non-full nutritional formula food for patients with hyperlipidemia |
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- 2022-09-14 CN CN202211116594.3A patent/CN115337377A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999020289A1 (en) * | 1997-10-22 | 1999-04-29 | R.P. Scherer Holdings Pty. Ltd. | Clear herbal extract solutions |
| CN104491751A (en) * | 2015-01-09 | 2015-04-08 | 王深涧 | Traditional Chinese medicine composition for treating fatty liver combined with hyperlipidemia and preparation method of traditional Chinese medicine composition |
| CN104855979A (en) * | 2015-04-22 | 2015-08-26 | 劲膳美生物科技股份有限公司 | Non-full nutritional formula food for patients with hyperlipidemia |
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| Title |
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| 张顺义: "《中华茶道 4》", vol. 1, 线装书局, pages: 604 * |
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