CN115335854A - 生物芯片图像的分析方法及装置、计算机设备和存储介质 - Google Patents

生物芯片图像的分析方法及装置、计算机设备和存储介质 Download PDF

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CN115335854A
CN115335854A CN202180000294.6A CN202180000294A CN115335854A CN 115335854 A CN115335854 A CN 115335854A CN 202180000294 A CN202180000294 A CN 202180000294A CN 115335854 A CN115335854 A CN 115335854A
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image
biochip
analyzing
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interest
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吴琼
侯孟军
马相国
耿凯
刘祝凯
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BOE Technology Group Co Ltd
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BOE Technology Group Co Ltd
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    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T5/00—Image enhancement or restoration
    • G06T5/80—Geometric correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T3/00—Geometric image transformations in the plane of the image
    • G06T3/40—Scaling of whole images or parts thereof, e.g. expanding or contracting
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T5/00—Image enhancement or restoration
    • G06T5/20—Image enhancement or restoration using local operators
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T5/00—Image enhancement or restoration
    • G06T5/50—Image enhancement or restoration using two or more images, e.g. averaging or subtraction
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T5/00—Image enhancement or restoration
    • G06T5/70—Denoising; Smoothing
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/11—Region-based segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/70—Determining position or orientation of objects or cameras
    • G06T7/77—Determining position or orientation of objects or cameras using statistical methods
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/80—Analysis of captured images to determine intrinsic or extrinsic camera parameters, i.e. camera calibration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10064—Fluorescence image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20048—Transform domain processing
    • G06T2207/20061—Hough transform
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20212—Image combination
    • G06T2207/20224—Image subtraction
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30072—Microarray; Biochip, DNA array; Well plate

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Probability & Statistics with Applications (AREA)
  • Image Processing (AREA)

Abstract

一种生物芯片图像的分析方法包括：(S1)获取生物芯片图像并进行预处理以得到预处理图像；(S2)对预处理图像进行角度偏转校正以得到偏转校正图像；(S3)对偏转校正图像进行增强处理并根据增强处理后的图像对预处理图像中兴趣区域的阴阳性进行识别。此外，还公开了一种生物芯片图像的分析装置(100)、图像的分析方法、计算机设备(200)及存储介质。

Description

PCT国内申请，说明书已公开。

Claims (21)

  1. PCT国内申请，权利要求书已公开。
CN202180000294.6A 2021-02-23 2021-02-23 生物芯片图像的分析方法及装置、计算机设备和存储介质 Pending CN115335854A (zh)

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EP (1) EP4141787A4 (zh)
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CN116704011A (zh) * 2023-08-04 2023-09-05 深圳市木兰轩科技有限公司 一种基于数据处理的led显示屏像素校正分析系统

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CN116528042B (zh) * 2023-06-29 2023-10-27 深圳市巨龙创视科技有限公司 一种远端摄像机的控制方法及系统
CN117671677B (zh) * 2024-02-02 2024-04-30 吉林省星博医疗器械有限公司 一种荧光微阵列识别分析方法及系统
CN117893611A (zh) * 2024-03-14 2024-04-16 浙江华诺康科技有限公司 一种图像传感器的脏污检测方法、装置和计算机设备

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CN1259570C (zh) * 2004-04-29 2006-06-14 南京大渊生物技术工程有限责任公司 生物芯片的检测方法
DE102009059112A1 (de) * 2009-12-18 2011-06-22 Biotype Diagnostic GmbH, 01109 Eine Vorrichtung zur Bestimmung molekularer Wechselwirkungen, sowie eine Folie zur Herstellung einer solchen
CN103236065B (zh) * 2013-05-09 2015-11-04 中南大学 基于主动轮廓模型和细胞神经网络的生物芯片分析方法
JP6931870B2 (ja) * 2017-02-15 2021-09-08 国立研究開発法人理化学研究所 細胞の再プログラム化を検出するための方法及び装置
CN107274349B (zh) * 2017-06-05 2021-03-09 新疆大学 生物芯片荧光图像倾斜角度的确定方法及装置
CN110047107B (zh) * 2018-01-13 2021-04-13 深圳华大智造科技股份有限公司 相机标定方法及图像配准方法、基因测序仪及系统
CN110310334B (zh) * 2018-03-20 2023-05-16 深圳市华大智造软件技术有限公司 生物芯片定位方法、基因测序仪及系统、存储介质
CN109234158B (zh) * 2018-10-08 2021-08-06 北京京东方技术开发有限公司 生物芯片及其制造方法、操作方法、生物检测系统
CN111257296B (zh) * 2020-03-20 2023-04-11 京东方科技集团股份有限公司 一种检测生物芯片样本的方法、装置及存储介质

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116704011A (zh) * 2023-08-04 2023-09-05 深圳市木兰轩科技有限公司 一种基于数据处理的led显示屏像素校正分析系统
CN116704011B (zh) * 2023-08-04 2024-03-05 深圳市凯立特光电科技有限公司 一种基于数据处理的led显示屏像素校正分析系统

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