CN115317234A - Intracavity heat perfusion medicine circulation pipeline system - Google Patents
Intracavity heat perfusion medicine circulation pipeline system Download PDFInfo
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- CN115317234A CN115317234A CN202210868793.3A CN202210868793A CN115317234A CN 115317234 A CN115317234 A CN 115317234A CN 202210868793 A CN202210868793 A CN 202210868793A CN 115317234 A CN115317234 A CN 115317234A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/0085—Devices for generating hot or cold treatment fluids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0086—Heating or cooling appliances for medical or therapeutic treatment of the human body with a thermostat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
- A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P70/00—Climate change mitigation technologies in the production process for final industrial or consumer products
- Y02P70/10—Greenhouse gas [GHG] capture, material saving, heat recovery or other energy efficient measures, e.g. motor control, characterised by manufacturing processes, e.g. for rolling metal or metal working
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Abstract
The utility model discloses an intracavity thermal perfusion medicine circulation pipeline system, which is used for solving the problems that the liquid in the existing thermal perfusion circulation pipeline has poor uniform heating effect and cell tissues in the circulation liquid are inconvenient to filter and clean; the water bag is detachably connected with a water outlet pipe, a water return pipe, an external circulation pipe and a medicine bag connecting pipe respectively, a peristaltic pump pipeline, a medical filter and a water heating device are connected in series on the water outlet pipe from near to far, a cell filter and a parallel pipeline connected with the cell filter in parallel are arranged in the middle section of the water return pipe through two three-way joints, the tail end of the water outlet pipe is divided into two branches through the three-way joints, a branch of the water outlet pipe, the water return pipe and the external circulation pipe are respectively connected in series with a temperature control tank body, the tail end of the branch and the tail end of the water return pipe are detachably connected with a silicon inlet rubber pipe respectively, and the other branch of the water outlet pipe is connected with the external circulation pipe.
Description
Technical Field
The disclosure relates to the technical field of body cavity hot perfusion equipment, in particular to a circulating pipeline system for medicine hot perfusion in a cavity.
Background
Malignant tumor of pleuroperitoneal cavity is easy to transfer and recur in cavity, often causing a large amount of effusion in cancerous cavity, especially gastrointestinal cancer generally recurs 50% of patients within one year after operation, 80% of patients within two years and 90% of patients within four years, which is the most main cause of death. At present, chemotherapy of malignant tumors of the thoracic cavity and the abdominal cavity and concentration and reinfusion treatment of a large amount of ascites are generally carried out by adopting a heat perfusion machine, wherein the heat perfusion machine mainly comprises a control system, a heating device and a perfusion system, and the heating device and the perfusion system are both connected with and controlled by the control system. In the heating device and the perfusion system, the perfusion system takes a circulating pipeline as a main body, the heating device is communicated on the circulating pipeline, and the circulating pipeline is reasonably arranged to be favorable for the circulating flow of liquid, so that the perfusion system is convenient for an attending doctor to operate and use.
The invention discloses a heat balance type circulating pipeline system in Chinese patent with the application number of CN201510111569.X, and introduces a circulating heat perfusion heating device, which comprises a molecular ring, a magnetic field generator and an internal stirrer, wherein the magnetic field generator of a heater, an induction coil wound on a sleeve and an inductor placed in a heating tank mutually induce to generate heat to heat liquid in the heating tank, and the impeller is impacted by the downward impact of the automatic flow of the liquid entering the heating tank when the liquid circularly enters the heating tank to drive the impeller to rotate, so that the stirring effect of the liquid is achieved, the water temperature in the heating tank is uniform, the phenomenon that the temperature difference between the upper water temperature and the lower water temperature is too large due to nonuniform heating is avoided, the overshoot phenomenon of the water temperature can be effectively prevented, and the molecular ring simultaneously kills and treats cancer cells in the liquid in the heating tank, and decomposes the cancer cells. However, the rotating shaft of the impeller of the internal stirrer is perpendicular to the axis of the heating tank, and the liquid flows from top to bottom to impact the impeller to rotate, so that the liquid in the heating tank cannot be stirred in a rotating manner by the rotating mode of the impeller, only the water in the heating tank can shake, and the liquid cannot be uniformly heated; in addition, the cancer cells decomposed by the molecular rings scattered in the heating tank cannot be effectively filtered, and the heating effect on the liquid in the heating tank body is also influenced.
Disclosure of Invention
In view of the above situation, in order to overcome the drawbacks of the prior art, the present disclosure provides an intracavity thermal perfusion drug circulation pipeline system, which solves the problems that the liquid in the existing thermal perfusion circulation pipeline has poor uniform heating effect and is not convenient for filtering and cleaning the cell tissue in the circulation liquid.
The technical scheme includes that the water bag comprises a water bag and a medicine bag, wherein a water outlet pipe, a water return pipe, an external circulation pipe and a medicine bag connecting pipe are detachably connected to the water bag respectively, a peristaltic pump pipeline, a medical filter and a water heating device are connected to the water outlet pipe in series from near to far, a cell filter and a parallel pipeline connected with the cell filter in parallel are arranged in the middle section of the water return pipe through two tee joints, the tail end of the water outlet pipe is divided into two branches through the tee joints, a branch of the water outlet pipe and the water outlet pipe, a water return pipe and the external circulation pipe are connected in series with a temperature control tank respectively, the tail end of each branch and the tail end of the water return pipe are detachably connected with a silicone inlet pipe respectively, and the other branch of the water outlet pipe is connected with the external circulation pipe;
the water heating device comprises an outer cup body, an inner cup body, a heat conducting core body and a heating body module, wherein a thread groove for guiding liquid is formed in the inner side wall of the outer cup body; the outer side end of the heat conducting core is provided with a plurality of jacks, the heating module comprises a plurality of heating rods with different lengths, and the plurality of heating rods are respectively inserted into different jacks;
the cell filter comprises a connecting cylinder and a filter element, the filter element is inserted into the connecting cylinder, a cross-shaped support is arranged inside the filter element, the cross-shaped support divides the inside of the filter element into four different areas, an ultrafiltration membrane and a filter screen are arranged inside each area from inside to outside respectively, each area is divided into the outside, the middle and the inside by the ultrafiltration membrane and the filter screen respectively, the ultrafiltration membrane and the filter screen are fixedly connected to side plates of the support respectively, a liquid collecting pipe coaxial with the filter element is arranged at the intersection of the support, four liquid collecting tanks which are communicated with the inside and the outside are arranged on the side wall of the liquid collecting pipe and correspond to the four areas one to one respectively, a conical blocking cap which blocks the middle and the inside of each area is arranged at one end of the filter element, a bottom plate which blocks the outside and the middle of each area is arranged at the other end of the filter element, and an interface communicated with the liquid collecting pipe is arranged on the bottom plate.
Preferably, the four temperature control tank bodies are divided into two straight-through types and two three-way types, blind holes are formed in the four temperature control tank bodies, temperature sensors are arranged in the blind holes, the straight-through type temperature control tank bodies are connected in series at positions, located between the peristaltic pump pipeline and the water bag, on the water outlet guide pipe, one end, close to the water bag, of the outer circulation guide pipe, the straight-through type temperature control tank bodies are connected in series, one branch of the water outlet guide pipe and the water return guide pipe are respectively connected with the three-way type temperature control tank bodies, and the other outlet of each of the two three-way type temperature control tank bodies is used for being connected with a standby silicon inlet rubber pipe.
Preferably, water stop clamps are respectively arranged on the two branches of the water outlet conduit and between the peristaltic pump pipeline and the temperature control tank body; water stopping clamps are respectively arranged at two ends of the cell filter and on parallel pipelines which are connected with the cell filter in parallel; a water stop clip is arranged on the water return pipeline; and the tail end of each silicon-in rubber pipe is provided with a water stop clip.
Preferably, above-mentioned heating body module still includes heating body shell and heating body base, be equipped with the main control board of being connected with the heating rod electricity in the heating body shell, heating body base fixed connection is between heating body shell and outer cup, set up a plurality of through-holes along its circumferencial direction equipartition on the heating body base, set up the via hole that is located between two through-holes on the heating body base, a plurality of foretell heating rods are pegged graft respectively in the through-hole of difference, the electricity is connected with temperature sensor on the main control board, this temperature sensor is pegged graft in the jack of heat conduction core through the hole.
Preferably, the opening end of the outer cup body is provided with a sealing gasket, and the sealing gasket is positioned between the outer cup body and the inner cup body.
Preferably, the outer cup is made of colorless transparent PC material, and the diameter of the opening of the outer cup is larger than that of the bottom.
Preferably, two ends of the connecting cylinder are respectively provided with a cover plate for plugging the port of the connecting cylinder, the cover plate is provided with a plug communicated with the inside of the connecting cylinder, and the plug is L-shaped.
Preferably, the inside filter bag that is equipped with 50um of above-mentioned water bag is equipped with 5 connecting pipes on the water bag, and wherein 1 connecting pipe is reserve connecting pipe.
Preferably, the heat conducting core is made of an aluminum alloy.
Preferably, the inner cup body is made of stainless steel
Compared with the prior art, the technical scheme provided by the disclosure has the following remarkable effects:
1. the two branch circuits are arranged on the water outlet conduit, one branch circuit is used for being connected with the external circulation conduit to carry out extracorporeal circulation, the other branch circuit is used for being connected with the silicone tube entering the body to carry out body cavity internal circulation, the two circulation pipelines are independently used, the perfusion liquid firstly carries out extracorporeal circulation, the circulation in the body cavity is carried out after the temperature of the perfusion liquid reaches the set temperature, and the temperature of the perfusion liquid is ensured to be kept constant all the time.
2. Through the structure that changes the water heating device on the circulating line, the thread groove has been set up on the inner wall of outer cup, liquid flows along between outer cup and the interior cup in the thread groove, cooperation heating member module is to the heating of heating core, the heat conducts to the filling liquid of flowing through in the thread groove through interior cup, so make the heating to filling liquid even more stable, in addition, through setting up the heating rod different in size, every heating rod can be controlled alone, realize multiple temperature control effect, improve the sensitivity of hot-water heating.
3. The cell filter is additionally arranged on the circulating pipeline, four filtering areas which act simultaneously are arranged in the cell filter, and liquid led out of the body is reasonably distributed to different areas to be filtered by matching with the conical blocking cap, so that the filtering effect is greatly improved, the normal use of other areas is not influenced by the blocking of one area, and the blocking of the circulating pipeline is prevented; in addition, the cell filter is convenient to disassemble, assemble and replace, and the water return pipeline is provided with a parallel pipeline which is connected with the cell filter in parallel, so that even if four areas of the cell filter are completely blocked, the pipeline can be used for internal circulation of liquid medicine, and normal operation of the circulating pipeline is ensured.
Drawings
FIG. 1 is a schematic view of a circulation line system of the present disclosure.
Fig. 2 is a schematic view of the external structure of the water heating apparatus of the present disclosure.
Fig. 3 is a schematic cross-sectional view of a water heating apparatus of the present disclosure.
Fig. 4 is a schematic structural view of a heating body module of the present disclosure.
FIG. 5 is a schematic view of a construction of a heat conduction assembly of the present disclosure.
Fig. 6 is a disassembled schematic view of the cell filter of the present disclosure.
Fig. 7 is a schematic structural view of a filter element of the present disclosure.
FIG. 8 is a schematic cross-sectional view of a cell filter of the present disclosure.
Fig. 9 is a schematic structural view of a three-way temperature controlled tank of the present disclosure.
FIG. 10 is a schematic view of the construction of a temperature controlled tank of the flow-through type of the present disclosure.
The reference numbers in the schematic drawings illustrate:
1. a water bag; 2. a medicine bag; 3. a water outlet conduit; 4. a return water conduit; 5. an outer circulation duct; 6. the medicine bag is connected with the catheter; 7. peristaltic pump tubing; 8. a cell filter; 801. a connecting cylinder; 802. a filter element; 8021. a support; 8022. ultrafiltration membranes; 8023. a filter screen; 8024. a liquid collecting pipe; 8025. a liquid collecting tank; 8026. a conical plug cap; 8027. a base plate; 8028. an interface; 803. a cover plate; 8031. a plug; 9. a water heating device; 901. a heat conducting component; 9011. an outer cup body; 9012. an inner cup body; 9013. a thermally conductive core; 9014. a thread groove; 9015. a connector; 9016. a jack; 902. a heater module; 9021. heating a rod; 9022. a heater housing; 9023. a heating body base; 10. a medical filter; 11. a temperature control tank body; 12. a silicon-inserted rubber hose; 13. blind holes; 14. a water stop clip; 15. a through hole; 16. a via hole; 17. a temperature sensor; 18. a gasket; 19. and (4) connecting the pipes.
Detailed Description
In the following discussion, details are given to provide a more thorough understanding of the present disclosure. One skilled in the relevant art will recognize, however, that the disclosure may be practiced without one or more of the specific details. In certain instances, well-known features have not been described in detail so as not to obscure the disclosure. It is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", and the like are used herein for purposes of illustration only and are not to be construed as limiting.
Ordinal words such as "first" and "second" are referred to in this disclosure merely as labels, and do not have any other meaning, e.g., a particular order, etc. Also, for example, the term "first component" does not itself imply the presence of "second component", and the term "second component" does not itself imply the presence of "first component".
The following detailed description of specific embodiments of the present disclosure is provided in connection with the accompanying drawings.
Referring to fig. 1-10, an intracavity hot-filling medicine-injection circulation pipeline system comprises a water bag 1 and a medicine bag 2, wherein the capacity of the water bag 1 is 3500ml, the capacity of the medicine bag 2 is 600ml, 5 connecting pipes 19 are arranged on the water bag 1, 4 of the connecting pipes 19 are respectively detachably connected with a water outlet pipe 3, a water return pipe 4, an outer circulation pipe 5 and a medicine bag connecting pipe 6, the other 1 connecting pipe 19 is a standby connecting pipe, the medicine bag connecting pipe 6 is used for communicating the medicine bag 2 with the water bag 1, the water outlet pipe 3 is inserted into the bottom of the water bag 1, a 50um filter bag is arranged inside the water bag 1 and is blocked at the end parts of the water return pipe 4, the outer circulation pipe 5 and the standby connecting pipe 19, liquid flowing back into the water bag 1 is further filtered, a peristaltic pump pipeline 7, a medical filter 10 and a water heating device 9 are respectively connected in series with the water outlet pipe 3 from near to far from the water bag 1, the middle section of the water return conduit 4 is provided with a cell filter 8 and a parallel pipeline connected with the cell filter 8 in parallel through two tee joints, liquid discharged from a human body cavity firstly enters the cell filter 8, cancer cell tissues brought out from the body cavity in the liquid are filtered, the pipe blockage is prevented, the tail end of the water outlet conduit 3 is divided into two branches through the tee joints, the water outlet conduit 3, one branch of the water outlet conduit 3, the water return conduit 4 and the external circulation conduit 5 are respectively connected with a temperature control tank body 11 in series, the tail end of the branch and the tail end of the water return conduit 4 are respectively detachably connected with a silicon rubber inlet pipe 12, the other branch of the water outlet conduit 3 is connected with the external circulation conduit 5, namely, one branch of the water outlet conduit 3 and the water return conduit 4 form an internal circulation pipeline, the perfusion circulation of the body cavity is realized, the other branch of the water outlet conduit 3 and the external circulation conduit 5 form an external circulation pipeline, the extracorporeal circulation is realized, the internal circulation pipeline is matched with the external circulation pipeline for use, the water heating device 9 works initially, the perfusion liquid firstly circulates through the external circulation pipeline until the perfusion liquid is heated to a set temperature, and then the perfusion liquid is converted into the internal circulation pipeline to circulate, so that the hot perfusion operation in the body cavity is carried out.
Furthermore, water stop clamps 14 are respectively arranged on the two branches of the water outlet conduit 3 and between the peristaltic pump pipeline 7 and the temperature control tank body 11; water stop clamps 14 are respectively arranged at two ends of the cell filter 8 and on parallel pipelines which are connected with the cell filter 8 in parallel; a water stop clip 14 is arranged on the water return pipeline; the tail end of each silicon inlet rubber pipe 12 is respectively provided with a water stop clip 14, the water stop clip 14 on the branch of the water outlet pipe 3 connected with the silicon inlet rubber pipe 12 is closed, the water stop clip 14 on the branch of the water outlet pipe 3 connected with the external circulation pipe 5 is opened, and at the moment, the external circulation operation of filling liquid can be carried out; and closing the water stop clamp 14 on the branch of the water outlet conduit 3 connected with the external circulation conduit 5, and opening the water stop clamp 14 on the branch of the water outlet conduit 3 connected with the silicon inlet silicone tube 12, so that the operation of circulating the perfusion liquid in the body cavity can be performed.
Further, as shown in fig. 9 and 10, the four temperature control tank bodies 11 are divided into two straight-through types and two three-way types, blind holes 13 for connecting temperature sensors 17 are formed in the four temperature control tank bodies 11, the straight-through type temperature control tank bodies 11 are connected in series at positions, located between the peristaltic pump pipeline 7 and the water bag 1, on the water outlet conduit 3, one end, close to the water bag 1, of the outer circulation conduit 5 is connected with the straight-through type temperature control tank bodies 11, a branch of the water outlet conduit 3 and the water return conduit 4 are respectively connected with the three-way type temperature control tank bodies 11, the four temperature control tank bodies 11 respectively monitor the initial temperature, the body inlet temperature, the body outlet temperature and the temperature during outer circulation of the filling liquid, the other outlet of the two three-way type temperature control tank bodies 11 is used for connecting with a spare body silicon inlet rubber tube 12, the four body inlet rubber tubes 12 are arranged in a group, namely two body rubber tubes 12 are arranged on a branch of the water outlet conduit 3 and used for filling the body liquid medicine into the body cavity, the two body rubber tubes 12 in the end of each group are arranged at the same time, so that the body cavity can be used independently, and the body cavity can be filled with the hot filling efficiency can be improved.
Referring to fig. 2, 3, 4, and 5, the water heating device 9 includes an outer cup 9011, an inner cup 9012, a heat conducting core 9013, and a heating body module 902, where the outer cup 9011, the inner cup 9012, and the heat conducting core 9013 form a heat conducting assembly 901, a threaded groove 9014 for guiding liquid is formed on an inner side wall of the outer cup 9011, two connectors 9015 respectively communicated with the threaded groove 9014 are formed on a side wall of the outer cup 9011, the two connectors 9015 are used to connect the water outlet conduit 3, and have different heights on the outer cup 9011, one connector 9015 is close to the bottom of the outer cup 9011, the other connector 9015 is close to an open end of the outer cup 9011, that is, the two connectors 9015 are respectively located at the head and tail ends of the threaded groove 9014, the heat conducting core 9013 is hermetically connected to the inner cup 9012, the inner cup 9012 is hermetically connected to the outer cup 9011, liquid flows in the two connectors 9015 through the threaded groove 9014, the threaded groove 9014 restricts the flow of the liquid between the outer cup 9011 and increases the flow of the liquid, and the temperature of the liquid flowing in the outer cup 9011, and increases the heated liquid flowing direction of the heated liquid; a plurality of jacks 9016 have been seted up to the outside end of heat conduction core, and the heating module includes a plurality of heating rods 9021 different in size, and a plurality of heating rods 9021 are pegged graft respectively in different jacks 9016, and heating rods 9021 different in size act on the different positions department in the heat conduction core respectively, and can the exclusive use or use simultaneously, and the rotatory flow of filling liquid is being cooperated like this, can realize the effect of multistage heating control, and temperature control effect is better.
Further, the heating body module 902 further includes a heating body housing 9022 and a heating body base 9023, a main control board electrically connected to the heating rods 9021 is disposed in the heating body housing 9022, the heating body base 9023 is fixedly connected between the heating body housing 9022 and the outer cup 9011, and is used to fix the heating body module 902 to the outer cup 9011, the heating body base 9023 is provided with a plurality of through holes 15 uniformly distributed along a circumferential direction of the heating body base, the heating body base 9023 is provided with a through hole 16 located between the two through holes 15, the heating rods 9021 are respectively inserted into different through holes 15, the main control board is electrically connected to a temperature sensor 17, the temperature sensor 17 is inserted into the insertion hole 9016 of the heat conducting core through the through hole 16 and is used to monitor a temperature of the heat conducting core 9013, in addition, the four temperature control tank bodies 11 are also respectively inserted with temperature sensors 17 to monitor a water outlet end and a water inlet end of the water bag 1, and temperatures of the filling liquid entering body end and a filling liquid outlet end on the circulation pipeline, so as to realize accurate monitoring of the filling liquid temperature in the whole circulation.
Further, as shown in fig. 3, a sealing gasket 18 is disposed at an opening end of the outer cup 9011, and the sealing gasket 18 is disposed between the outer cup 9011 and the inner cup 9012, so as to ensure a sealing effect between the outer cup 9011 and the inner cup 9012 and prevent the filling liquid from leaking out.
Further, the outer cup 9011 is made of a colorless and transparent PC material, so that the circulation flowing condition of the filling liquid can be clearly observed, and the diameter of the opening of the outer cup 9011 is larger than that of the bottom of the outer cup, so that the inner cup 9012 and the heat conducting core 9013 can be assembled conveniently.
Further, the inner cup 9012 is made of stainless steel, and the heat conducting core 9013 is made of aluminum alloy, so that heat conduction is facilitated.
Referring to fig. 6, 7 and 8, the cell filter 8 includes a connecting cylinder 801 and a filter element 802, the filter element 802 is inserted into the connecting cylinder 801, a cross-shaped support 8021 is disposed inside the filter element 802, the cross-shaped support 8021 divides the inside of the filter element 802 into four different areas, an ultrafiltration membrane 8022 and a filter screen 8023 are disposed inside each area from inside to outside, the ultrafiltration membrane 8022 and the filter screen 8023 divide each area into three layers, which are respectively an outer part, a middle part and an inner part, the ultrafiltration membrane 8022 and the filter screen 8023 are respectively fixedly connected to side plates of the support 8021, a liquid collecting pipe 8024 coaxial with the filter element 802 is disposed at a cross point of the support 8021, four liquid collecting tanks 8025 penetrating inside and outside are disposed on a side wall of the liquid collecting pipe 8024, the four liquid collecting tanks 8025 correspond to the four areas one by one, one end of the filter element 802 is provided with a conical plugging cap 8026 for plugging the middle part and the inner part in the area, the other end of the filter element 802 is provided with a bottom plate 8027 for plugging the outer part and the middle part in the area, the bottom plate 8027 is provided with an interface 8028 communicated with the liquid collecting pipe 8024, so that the cell filter 8 is provided with four separately used areas, each area is provided with two layers of filtering, the medical filter 10 on the water outlet conduit 3 and the filter bag in the medicine bag 2 act together to realize effective filtering of the circulating perfusion liquid, various cell tissues brought out from the body cavity of the human body in the circulating liquid are filtered out, the circulation smoothness of the perfusion liquid is ensured, and the treatment effect of hot perfusion is favorably improved.
Furthermore, two ends of the connecting cylinder 801 are respectively provided with a cover plate 803 for sealing the port, the cover plate 803 is provided with a plug 8031 communicated with the inside of the connecting cylinder 801, the two plugs 8031 are L-shaped, the connector 8028 is trumpet-shaped, one connector is butted with the trumpet-shaped connector 8028 to serve as a water outlet port of the filter element 802, the other plug 8031 is butted with the cone-shaped plugging cap 8026 to serve as a water inlet port of the filter element 802, the perfusion liquid discharged from the human body flows into the cell filter 8 through the water inlet port, and the liquid is shunted by the cone-shaped plugging cap 8026 to enter different areas, even if one area is plugged, the whole use of the cell filter 8 is not influenced, in addition, after the cell filter 8 is completely plugged, a new cell filter 8 can be quickly replaced, or the cell filter 8 is short-connected by a parallel pipeline connected with the cell filter 8 in parallel, so as to ensure the normal operation of the whole circulation pipeline.
When the device is used, the circulating flow of the perfusion liquid is realized by using a peristaltic pump under the control of a host machine of a hot perfusion instrument, the perfusion liquid flows out of a water bag 1 into a water outlet conduit 3, firstly passes through a medical filter 10 and then enters a water heating device 9, the extracorporeal circulation or the intracorporeal circulation of the perfusion liquid is realized by using the opening and closing of a plurality of water stopping clamps 14, before the intracorporeal circulation is carried out, the extracorporeal circulation is required to be firstly carried out, the water stopping clamps 14 on a branch of the water outlet conduit 3 connected with a silicone inlet pipe 12 are closed, the water stopping clamps 14 on a branch of the water outlet conduit 3 connected with a silicone inlet pipe 5 are opened, the water outlet conduit 3, the silicone inlet pipe 5 and the water bag 1 form a closed loop, the liquid medicine circulates in the closed loop until the liquid medicine is heated to a set temperature, the water stopping clamps 14 on the branch of the water outlet conduit 3 connected with the silicone inlet pipe 5 are closed, the water stopping clamps 14 on the branch of the water outlet conduit 3 connected with the silicone inlet pipe 12 are opened, the water outlet conduit 3 and the silicone inlet pipe 12 and the silicone pipe 4 form a loop with a body cavity of a perfusion pipeline; the number of the two groups of silicon inlet rubber tubes 12 is reasonably selected, and generally, two silicon inlet rubber tubes 12 are adopted in each group, namely four silicon inlet rubber tubes 12 are used simultaneously, so that the hot filling effect is enhanced, and the pipeline blockage can be avoided;
in the circulation process of the filling liquid, a heating body module 902 in the water heating device 9 provides a heating source, the filling liquid flows in the thread groove by matching with a heat conduction assembly 901 consisting of the outer cup body 9011, the inner cup body 9012 and the heat conduction core body 9013, so that the uniform heating of the filling liquid can be realized, and the body entering temperature of the filling liquid can be accurately and stably controlled;
when the water stop clamps 14 at the two ends of the cell filter 8 are opened and the water stop clamps 14 on the pipeline connected with the cell filter 8 in parallel are closed, mixed liquid led out through a human body cavity can firstly pass through the cell filter 8, so that cancer cell tissue brought out through the human body cavity is filtered out from circulating liquid, the cell filter 8 is provided with four regions which act simultaneously, one region is blocked timely, normal use of other regions cannot be influenced, in addition, liquid flowing back into the water bag 1 is filtered once again through the filter bag, and perfusion liquid enters the water outlet conduit 3 and is filtered once by the medical filter 10, so that a certain link of the circulating pipeline is prevented from being blocked, stable operation of the hot perfusion medicine circulating pipeline in the cavity is ensured, and the hot perfusion treatment effect is improved.
The above-described embodiments are merely illustrative of several embodiments of the present disclosure, which are described in more detail and detail, but should not be construed as limiting the scope of the present disclosure. It should be noted that, for those skilled in the art, various changes and modifications can be made without departing from the concept of the present disclosure, and these changes and modifications are all within the scope of the present disclosure. Therefore, the protection scope of the present disclosure should be subject to the appended claims.
Claims (10)
1. A kind of intracavitary hot perfusion medicine-injection circulation pipe system, including water bag and medicine bag, characterized by, dismantle and connect with the water outlet conduit, return water conduit, outer circulation conduit, connecting conduit of the medicine bag separately on the water bag, the peristaltic pump pipeline, medical filter, water heating arrangement are connected in series separately from water bag on the water outlet conduit from near to far, the middle section of return water conduit has cell filters and parallel pipeline connected in parallel with cell filters through two three-way joints, the end of the water outlet conduit divides into two branches by the three-way joint, one branch, return water conduit and outer circulation conduit of the water outlet conduit are connected in series with the temperature control tank body separately, and the end of the branch and end of the return water conduit are dismantled and connected with the silicone tube of entering separately, another branch and outer circulation conduit of the water outlet conduit are connected;
the water heating device comprises a heat conduction assembly and a heating body module, the heat conduction assembly comprises an outer cup body, an inner cup body and a heat conduction core body, a thread groove for guiding liquid is formed in the inner side wall of the outer cup body, two connectors which are respectively communicated with the thread groove are arranged on the side wall of the outer cup body, the two connectors are used for connecting a water outlet conduit, the two connectors are different in height on the outer cup body, the heat conduction core body is hermetically connected in the inner cup body, the inner cup body is hermetically connected in the outer cup body, and the liquid flows in the two connectors through the thread groove; the outer side end of the heat conducting core is provided with a plurality of jacks, the heating module comprises a plurality of heating rods with different lengths, and the plurality of heating rods are respectively inserted into different jacks;
the cell filter includes a connecting cylinder and a filter element, the filter element is inserted in the connecting cylinder, a cross-shaped support is arranged inside the filter element, the cross-shaped support divides the inside of the filter element into four different regions, an ultrafiltration membrane and a filter screen are respectively arranged inside each region from inside to outside, the ultrafiltration membrane and the filter screen divide each region into an outer region, a middle region and an inner three-layer region, a liquid collecting pipe coaxial with the filter element is arranged at the cross point of the support, four liquid collecting tanks which are communicated with the inner region and the outer region are arranged on the side wall of the liquid collecting pipe, the four liquid collecting tanks are respectively in one-to-one correspondence with the regions, one end of the filter element is provided with a conical plugging cap which is used for plugging the middle region and the inner region, the other end of the filter element is provided with a bottom plate which is used for plugging the outer region and the middle region, and an interface communicated with the liquid collecting pipe is arranged on the bottom plate.
2. The intracavity heat-perfusion medicine-injecting circulating pipeline system according to claim 1, wherein the four temperature control tank bodies are divided into two straight-through type and two three-way type, each of the four temperature control tank bodies is provided with a blind hole, a temperature sensor is arranged in the blind hole, the straight-through type temperature control tank body is connected in series with a part of the water outlet conduit between the peristaltic pump pipeline and the water bag, the straight-through type temperature control tank body is connected in series with one end of the outer circulating conduit close to the water bag, one branch of the water outlet conduit and the water return conduit are respectively connected with the three-way type temperature control tank body, and the other outlet of the two three-way type temperature control tank bodies is used for connecting a spare silicon inlet rubber hose.
3. The intracavity thermal perfusion drug circulation pipeline system as claimed in claim 1, wherein water stop clamps are respectively arranged on the two branches of the water outlet conduit and between the peristaltic pump pipeline and the temperature control tank body; in the backwater conduit, water stopping clamps are respectively arranged at two ends of the cell filter and on parallel pipelines which are connected with the cell filter in parallel; a water stop clip is arranged on the water return pipeline; and the tail end of each silicone tube inserted into the body is provided with a water stop clip.
4. The intracavity thermal perfusion drug circulation pipeline system according to claim 1, wherein the heating body module further comprises a heating body shell and a heating body base, a main control board electrically connected with the heating rods is arranged in the heating body shell, the heating body base is fixedly connected between the heating body shell and the outer cup body, a plurality of through holes uniformly distributed along the circumferential direction of the heating body base are formed in the heating body base, via holes between the two through holes are formed in the heating body base, the heating rods are respectively inserted into different through holes, a temperature sensor is electrically connected to the main control board, and the temperature sensor is inserted into the insertion holes of the heat conducting core through the holes.
5. The intracavity thermal perfusion drug circulation pipeline system of claim 4, wherein the open end of the outer cup body is provided with a sealing gasket, and the sealing gasket is positioned between the outer cup body and the inner cup body.
6. The intracavity thermal perfusion drug circulating pipeline system as claimed in claim 1, wherein the connecting cylinder is provided at both ends thereof with cover plates respectively for plugging the ports thereof, the cover plates are provided with plugs communicated with the inside of the connecting cylinder, and the plugs are L-shaped.
7. The intracavity thermal perfusion drug circulation pipeline system of claim 1, wherein the water bag is provided with a 50um filter bag inside, the water bag is provided with 5 connecting pipes, and 1 connecting pipe is a spare connecting pipe.
8. The intracavity thermal perfusion drug circulation pipeline system of claim 1, wherein the outer cup body is made of colorless and transparent PC material, and the diameter of the opening part of the outer cup body is larger than that of the bottom part.
9. The intracavity thermal infusion circulation line system of claim 1, wherein said inner cup is stainless steel.
10. The intracavity thermal perfusion drug circulation pipeline system of claim 1, wherein the thermally conductive core is made of an aluminum alloy.
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| CN115317234B (en) | 2023-07-18 |
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