CN115300676A - Medicine-carrying medical instrument and preparation method thereof - Google Patents

Medicine-carrying medical instrument and preparation method thereof Download PDF

Info

Publication number
CN115300676A
CN115300676A CN202210943572.8A CN202210943572A CN115300676A CN 115300676 A CN115300676 A CN 115300676A CN 202210943572 A CN202210943572 A CN 202210943572A CN 115300676 A CN115300676 A CN 115300676A
Authority
CN
China
Prior art keywords
magnesium alloy
parts
medical
preparation
raw materials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202210943572.8A
Other languages
Chinese (zh)
Inventor
李双
符劲飞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xiangya Hospital of Central South University
Original Assignee
Xiangya Hospital of Central South University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xiangya Hospital of Central South University filed Critical Xiangya Hospital of Central South University
Priority to CN202210943572.8A priority Critical patent/CN115300676A/en
Publication of CN115300676A publication Critical patent/CN115300676A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/02—Making non-ferrous alloys by melting
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C23/00—Alloys based on magnesium
    • C22C23/06—Alloys based on magnesium with a rare earth metal as the next major constituent
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
    • C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
    • C22F1/02—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working in inert or controlled atmosphere or vacuum
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
    • C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
    • C22F1/06—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Metallurgy (AREA)
  • Mechanical Engineering (AREA)
  • Materials Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A medicine-carrying medical device and a preparation method thereof. In order to prolong the service life of the medicine-carrying medical instrument, the invention adds rare earth elements of lanthanum and cerium into the traditional medical magnesium alloy material. Research shows that the doping of the rare earth elements La and Ce is helpful for improving the corrosion resistance of the medical Mg-2Gd-0.5Zr alloy, and when the same amount is used, the effect of using two metals simultaneously is more remarkable than the effect of using a single metal. In addition, the use amount of the rare earth with a proper amount has a positive effect on the biocompatibility of the magnesium alloy while improving the corrosion resistance of the magnesium alloy, but when the rare earth is used excessively, the biocompatibility is deteriorated, so that the magnesium alloy material cannot be used as a medical material.

Description

Medicine-carrying medical instrument and preparation method thereof
Technical Field
The invention relates to the field of medical instruments, in particular to a drug-loaded medical instrument and a preparation method thereof.
Background
Drug-loaded medical devices, such as medical stent materials, are widely used in clinical medical practice, and magnesium alloys are largely used for preparing medical devices due to their excellent properties. However, the weak corrosion resistance is a problem that medical magnesium alloy has not been solved, and the method for improving the corrosion resistance of magnesium alloy in industry generally causes the biocompatibility of magnesium alloy to be reduced, so that the magnesium alloy cannot be applied to the medical field. Aiming at the problems in the prior art, in order to prolong the service life of a medicine-carrying medical instrument, a magnesium alloy medicine-carrying medical material which has excellent corrosion resistance and biocompatibility and meets the medical requirement needs is necessary to be designed.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to provide a drug-loaded medical device and a preparation method thereof.
The invention provides a preparation method of a medicine-carrying medical instrument, which comprises the following steps:
coating a medicine on the surface of a medical appliance, wherein the medicine comprises one or more of dexamethasone, paclitaxel, rapamycin or derivatives thereof, and the medical appliance is processed from Mg-Ce-La-Gd-Zr magnesium alloy.
Preferably, the magnesium alloy is processed into a rod-like, wire-like, net-like, spherical or porous structure.
Preferably, the medical device is a medical stent material.
Preferably, the Mg-Ce-La-Gd-Zr magnesium alloy is prepared by the following method: weighing 97.5-99 parts of magnesium, 2-3 parts of gadolinium, 0.5-1 part of zirconium, 2-6.2 parts of lanthanum and 2-6.2 parts of cerium as raw materials, putting the raw materials into a resistance furnace, heating and melting the raw materials, then preserving heat for 60-90min, and stirring at the speed of 300-500r/min in the heat preservation process to uniformly distribute all the components; then casting to obtain Mg-Ce-La-Gd-Zr magnesium alloy, putting the Mg-Ce-La-Gd-Zr magnesium alloy into a box type resistance furnace, carrying out solution treatment for 12-15h at 430-450 ℃, taking out and cooling under protective gas.
Preferably, the composition of the raw material is 97.5 parts by weight of magnesium, 2 parts by weight of gadolinium, 0.5 parts by weight of zirconium, 3 parts by weight of lanthanum and 3.2 parts by weight of cerium.
Further, the invention also provides a medicine-carrying medical device, which is prepared by the preparation method.
In order to prolong the service life of the medicine-carrying medical instrument, the invention adds rare earth elements of lanthanum and cerium into the traditional medical magnesium alloy material. Research shows that the doping of the rare earth elements La and Ce is helpful for improving the corrosion resistance of the medical Mg-2Gd-0.5Zr alloy, and when the same amount is used, the effect of using two metals simultaneously is more remarkable than the effect of using a single metal. In addition, the use amount of the rare earth with a proper amount has a positive effect on the biocompatibility of the magnesium alloy while improving the corrosion resistance of the magnesium alloy, but when the rare earth is used excessively, the biocompatibility is deteriorated, so that the magnesium alloy material cannot be used as a medical material.
Detailed Description
The technical effects of the present invention are demonstrated below by specific examples, but the embodiments of the present invention are not limited thereto.
Example 1
The preparation method of the medical magnesium alloy comprises the following steps: weighing 97.5g of magnesium, 2g of gadolinium, 0.5g of zirconium, 3g of lanthanum and 3.2g of cerium as raw materials, putting the raw materials into a resistance furnace, heating and melting the raw materials, and then preserving heat for 60min, wherein the stirring is carried out at the speed of 300r/min in the heat preservation process, so that the components are uniformly distributed. Then casting is carried out to obtain the Mg-Ce-La-Gd-Zr magnesium alloy. Putting the Mg-Ce-La-Gd-Zr magnesium alloy into a box-type resistance furnace, carrying out solution treatment for 12h at 430 ℃, taking out and cooling under protective gas.
Example 2
The preparation method of the medical magnesium alloy comprises the following steps: weighing 97.5g of magnesium, 2g of gadolinium, 0.5g of zirconium and 6.2g of lanthanum as raw materials, putting the raw materials into a resistance furnace, heating and melting the raw materials, and then preserving heat for 60min, wherein the stirring is carried out at the speed of 300r/min in the heat preservation process, so that the components are uniformly distributed. Then casting is carried out to obtain the Mg-Ce-La-Gd-Zr magnesium alloy. Putting the Mg-Ce-La-Gd-Zr magnesium alloy into a box-type resistance furnace, carrying out solution treatment for 12h at 430 ℃, taking out and cooling under protective gas.
Example 3
The preparation method of the medical magnesium alloy comprises the following steps: weighing 97.5g of magnesium, 2g of gadolinium, 0.5g of zirconium and 6.2g of cerium as raw materials, putting the raw materials into a resistance furnace, heating and melting the raw materials, and then preserving heat for 60min, wherein the stirring is carried out at the speed of 300r/min in the heat preservation process, so that the components are uniformly distributed. Then casting is carried out to obtain the Mg-Ce-La-Gd-Zr magnesium alloy. Putting the Mg-Ce-La-Gd-Zr magnesium alloy into a box-type resistance furnace, carrying out solution treatment for 12h at 430 ℃, taking out and cooling under protective gas.
Example 4
The preparation method of the medical magnesium alloy comprises the following steps: weighing 97.5g of magnesium, 2g of gadolinium, 0.5g of zirconium, 2g of lanthanum and 2g of cerium as raw materials, putting the raw materials into a resistance furnace, heating and melting the raw materials, and then preserving heat for 60min, wherein the stirring is carried out at the speed of 300r/min in the heat preservation process, so that the components are uniformly distributed. Then casting is carried out to obtain the Mg-Ce-La-Gd-Zr magnesium alloy. Putting the Mg-Ce-La-Gd-Zr magnesium alloy into a box-type resistance furnace, carrying out solution treatment for 12h at 430 ℃, taking out and cooling under protective gas.
Example 5
The preparation method of the medical magnesium alloy comprises the following steps: weighing 97.5g of magnesium, 2g of gadolinium, 0.5g of zirconium, 6g of lanthanum and 6g of cerium as raw materials, putting the raw materials into a resistance furnace, heating and melting the raw materials, keeping the temperature for 60min, and stirring at the speed of 300r/min in the heat preservation process to uniformly distribute all the components. Then casting is carried out to obtain the Mg-Ce-La-Gd-Zr magnesium alloy. Putting the Mg-Ce-La-Gd-Zr magnesium alloy into a box-type resistance furnace, carrying out solution treatment for 12h at 430 ℃, taking out and cooling under protective gas.
Comparative example 1
The preparation method of the medical magnesium alloy comprises the following steps: weighing 97.5g of magnesium, 2g of gadolinium, 0.5g of zirconium, 1g of lanthanum and 1g of cerium as raw materials, putting the raw materials into a resistance furnace, heating and melting the raw materials, and then preserving heat for 60min, wherein the stirring is carried out at the speed of 300r/min in the heat preservation process, so that the components are uniformly distributed. Then casting is carried out to obtain the Mg-Ce-La-Gd-Zr magnesium alloy. Putting the Mg-Ce-La-Gd-Zr magnesium alloy into a box-type resistance furnace, carrying out solution treatment for 12h at 430 ℃, taking out and cooling under protective gas.
Comparative example 2
The preparation method of the medical magnesium alloy comprises the following steps: weighing 97.5g of magnesium, 2g of gadolinium, 0.5g of zirconium, 10g of lanthanum and 10g of cerium as raw materials, putting the raw materials into a resistance furnace, heating and melting the raw materials, and then preserving heat for 60min, wherein the stirring is carried out at the speed of 300r/min in the heat preservation process, so that the components are uniformly distributed. Then casting is carried out to obtain the Mg-Ce-La-Gd-Zr magnesium alloy. Putting the Mg-Ce-La-Gd-Zr magnesium alloy into a box-type resistance furnace, carrying out solution treatment for 12h at 430 ℃, taking out and cooling under protective gas.
Comparative example 3
The medical Mg alloy Mg-2Gd-0.5Zr which is sold in the market is selected as a reference.
Next, we evaluated the corrosion resistance and biocompatibility of the magnesium alloys of examples 1 to 5 and comparative examples 1 to 3 by the following specific methods:
corrosion resistance: an electrochemical workstation is adopted to carry out electrochemical test on each sample in simulated body fluid PBS, and the specific test method can refer to the research on the mechanical property and the corrosion property of Mg-Gd series alloy for the esophageal stent material in the prior art;
biocompatibility: the hemocompatibility of each sample was evaluated by a hemolysis test, which is based on the following principle: the sample is directly contacted with blood, and the amount of hemoglobin released after rupture of the erythrocyte membrane is measured to detect the degree of hemolysis of each sample in vitro. The absorption wavelength of hemoglobin is 545nm, and its concentration can be detected by a spectrophotometer. The specific operation steps are as follows:
(1) Blood is collected from the heart of a healthy rabbit by 100mL, and 2% potassium oxalate by 5mL is added to prepare fresh anticoagulation blood. And taking 40mL of anticoagulation blood, and adding 50mL of 0.9% sodium chloride injection for dilution.
(2) Taking 3 silicified test tubes, loading a test sample and 10mL of sodium chloride injection into one test tube, taking a blank of one test tube as a negative control group, adding 10mL of sodium chloride normal saline, and taking a blank of the other test tube as a positive control group, and respectively adding 10mL of distilled water.
(3) All the test tubes are kept constant in a water bath at 37 ℃ for 30min, 5mL of anticoagulated rabbit blood is added respectively, and the temperature is kept at 37 ℃ for 60min.
(4) The supernatant of the test tube was collected and the absorbance was measured at 545 nm. Three replicates of each sample were run and averaged.
The hemolysis rate is calculated as follows:
hemolysis rate (%) = (sample average absorbance-absorbance in negative group)/(absorbance in positive group-absorbance in negative group) × 100.
The results of the experiment are shown in table 1.
TABLE 1
Figure BDA0003786768890000041
As can be seen from Table 1, the incorporation of rare earth elements La and Ce contributes to the improvement of the corrosion resistance of the Mg-2Gd-0.5Zr medical magnesium alloy, and when the same amount is used, the effect of using two metals simultaneously is more remarkable than the effect of using a single metal. In addition, the use amount of the rare earth with a proper amount has a positive effect on the biocompatibility of the magnesium alloy while improving the corrosion resistance of the magnesium alloy, but when the rare earth is used excessively, the biocompatibility is deteriorated, so that the magnesium alloy material cannot be used as a medical material.
Further, the Mg-Ce-La-Gd-Zr magnesium alloy can be processed into a proper shape by a person skilled in the art, such as a rod-shaped, a wire-shaped, a net-shaped, a ball-shaped or a porous structure, so as to meet the use requirement of clinical medicine. And, drugs including but not limited to dexamethasone, paclitaxel, rapamycin or derivatives thereof, etc. can be loaded on the surface of the medical magnesium alloy by the method known in the prior art.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.

Claims (6)

1. A preparation method of a drug-loaded medical device is characterized by comprising the following steps:
coating a medicine on the surface of a medical appliance, wherein the medicine comprises one or more of dexamethasone, paclitaxel, rapamycin or derivatives thereof, and the medical appliance is processed from Mg-Ce-La-Gd-Zr magnesium alloy.
2. A method according to claim 1, wherein the magnesium alloy is processed into a rod-like, wire-like, net-like, spherical or porous structure.
3. The method of claim 1, wherein the medical device is a medical stent material.
4. The preparation method according to claim 1, wherein the Mg-Ce-La-Gd-Zr magnesium alloy is prepared by the following method: weighing 97.5-99 parts of magnesium, 2-3 parts of gadolinium, 0.5-1 part of zirconium, 2-6.2 parts of lanthanum and 2-6.2 parts of cerium as raw materials, putting the raw materials into a resistance furnace, heating and melting the raw materials, then preserving heat for 60-90min, and stirring at the speed of 300-500r/min in the heat preservation process to uniformly distribute all the components; then casting to obtain Mg-Ce-La-Gd-Zr magnesium alloy, putting the Mg-Ce-La-Gd-Zr magnesium alloy into a box type resistance furnace, carrying out solution treatment for 12-15h at 430-450 ℃, taking out and cooling under protective gas.
5. The method of claim 1, wherein the raw material comprises 97.5 parts by weight of magnesium, 2 parts by weight of gadolinium, 0.5 parts by weight of zirconium, 3 parts by weight of lanthanum, and 3.2 parts by weight of cerium.
6. A drug-loaded medical device, wherein the drug-loaded medical device is prepared by the preparation method of any one of claims 1 to 5.
CN202210943572.8A 2022-08-08 2022-08-08 Medicine-carrying medical instrument and preparation method thereof Pending CN115300676A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210943572.8A CN115300676A (en) 2022-08-08 2022-08-08 Medicine-carrying medical instrument and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210943572.8A CN115300676A (en) 2022-08-08 2022-08-08 Medicine-carrying medical instrument and preparation method thereof

Publications (1)

Publication Number Publication Date
CN115300676A true CN115300676A (en) 2022-11-08

Family

ID=83860334

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210943572.8A Pending CN115300676A (en) 2022-08-08 2022-08-08 Medicine-carrying medical instrument and preparation method thereof

Country Status (1)

Country Link
CN (1) CN115300676A (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080262589A1 (en) * 2005-01-28 2008-10-23 Terumo Kabushiki Kaisha Intravascular Implant
US20090175754A1 (en) * 2006-09-13 2009-07-09 Magnesium Elektron Limited Magnesium gadolinium alloys
CN104630895A (en) * 2014-12-30 2015-05-20 中国兵器科学研究院宁波分院 Single-crystal magnesium alloy biodegradable material and preparation method thereof
CN105395298A (en) * 2014-09-04 2016-03-16 汤敬东 Partially degradable blood vessel stent and preparation method thereof
CN108359868A (en) * 2018-03-10 2018-08-03 温州市赢创新材料技术有限公司 It is a kind of to be used to be implanted into magnesium alloy of bone and preparation method thereof
CN109628814A (en) * 2019-02-22 2019-04-16 中国科学院长春应用化学研究所 Weight rare earth complex intensifying heat resistance magnesium alloy and preparation method thereof
CN110016600A (en) * 2019-05-17 2019-07-16 烟台浩忆生物科技有限公司 High-intensitive highly corrosion resistant bio-medical Mg-Ga alloy and preparation method thereof
CN110468319A (en) * 2019-08-13 2019-11-19 中国兵器科学研究院宁波分院 A kind of novel Mg-Y-Nd- (La+Ce)-Zr biodegradable magnesium alloy and preparation method thereof
CN114672711A (en) * 2022-04-15 2022-06-28 重庆大学 Novel low-expansion binary magnesium alloy and preparation method thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080262589A1 (en) * 2005-01-28 2008-10-23 Terumo Kabushiki Kaisha Intravascular Implant
US20090175754A1 (en) * 2006-09-13 2009-07-09 Magnesium Elektron Limited Magnesium gadolinium alloys
CN105395298A (en) * 2014-09-04 2016-03-16 汤敬东 Partially degradable blood vessel stent and preparation method thereof
CN104630895A (en) * 2014-12-30 2015-05-20 中国兵器科学研究院宁波分院 Single-crystal magnesium alloy biodegradable material and preparation method thereof
CN108359868A (en) * 2018-03-10 2018-08-03 温州市赢创新材料技术有限公司 It is a kind of to be used to be implanted into magnesium alloy of bone and preparation method thereof
CN109628814A (en) * 2019-02-22 2019-04-16 中国科学院长春应用化学研究所 Weight rare earth complex intensifying heat resistance magnesium alloy and preparation method thereof
CN110016600A (en) * 2019-05-17 2019-07-16 烟台浩忆生物科技有限公司 High-intensitive highly corrosion resistant bio-medical Mg-Ga alloy and preparation method thereof
CN110468319A (en) * 2019-08-13 2019-11-19 中国兵器科学研究院宁波分院 A kind of novel Mg-Y-Nd- (La+Ce)-Zr biodegradable magnesium alloy and preparation method thereof
CN114672711A (en) * 2022-04-15 2022-06-28 重庆大学 Novel low-expansion binary magnesium alloy and preparation method thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
吴存: "稀土元素在医用镁合金中应用的研究进展", 热加工工艺, vol. 47, no. 18, pages 15 - 17 *
唐定骧: "稀土金属材料", 北京：冶金工业出版社, pages: 659 *
尹林: "可降解镁合金临床应用的最新研究进展", 中国材料进展, vol. 38, no. 2, pages 126 - 137 *
赵兵;韩少兵;贾长健;许春香;张金山;: "Gd对心血管支架用Mg-Zn-Gd-Zr合金的腐蚀性能的影响", 中国铸造装备与技术, no. 04, pages 7 - 10 *

Similar Documents

Publication Publication Date Title
Aurelio et al. Contrast-induced nephropathy in percutaneous coronary interventions: pathogenesis, risk factors, outcome, prevention and treatment
Dworkin et al. Effects of nifedipine and enalapril on glomerular injury in rats with deoxycorticosterone-salt hypertension
PANDOLFI et al. Increased von Willebrand‐antihaemophilic factor A in diabetic retinopathy
CN107456610A (en) A kind of Zn-Ag systems kirsite and preparation method and application
BRPI0708993A2 (en) binds the magnesium base with an enhanced combination of mechanical and corrosive characteristics
Montenegro et al. Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension
Kaga et al. Cytotoxicity of amalgams, alloys, and their elements and phases
Boneu et al. The role of the hematocrit in bleeding
CN106086562B (en) Biological degradable in vivo anastomosis staple and its production technology
JP7053508B2 (en) Methods for managing adverse events in a population of patients requiring blood transfusions
Bing et al. L-arginine impacts pulmonary vascular structure in rats with an aortocaval shunt
CN108048690A (en) A kind of zinc-containing alloy of controllable degradation rate, preparation method and application
Ben Ali et al. The effect of storage solutions, gene therapy, and antiproliferative agents on endothelial function and saphenous vein graft patency
Xu et al. Biodegradable Zn-Cu-Fe alloy as a promising material for craniomaxillofacial implants: an in vitro investigation into degradation behavior, cytotoxicity, and hemocompatibility
Wang et al. Effects of an angelica extract on human erythrocyte aggregation, deformation and osmotic fragility
CN115300676A (en) Medicine-carrying medical instrument and preparation method thereof
CN113973805A (en) Cell cryopreservation kit and using method thereof
CN104451269B (en) A kind of cobalt-base alloys and its hot-working, heat treatment method and application
Fuhrman et al. Oxygen consumption of excised rat tissues following acute anoxic anoxia
WO2007107286A2 (en) Magnesium-based alloy with improved combination of mechanical and corrosion characteristics
Salgado Non beating heart donors as a possible source for liver transplantation
Mulvany et al. Are isolated femoral resistance vessels or tail arteries good models for the hindquarter vasculature of spontaneously hypertensive rats?
CN113373403B (en) Modification method for gas nitriding on surface of intestinal stent
Cotton et al. Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery
Catanese et al. Erythrocyte membrane stabilization and protein binding of some anti-inflammatory drugs and of deoxycholic acid

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination