CN106086562B - Biological degradable in vivo anastomosis staple and its production technology - Google Patents
Biological degradable in vivo anastomosis staple and its production technology Download PDFInfo
- Publication number
- CN106086562B CN106086562B CN201610592979.5A CN201610592979A CN106086562B CN 106086562 B CN106086562 B CN 106086562B CN 201610592979 A CN201610592979 A CN 201610592979A CN 106086562 B CN106086562 B CN 106086562B
- Authority
- CN
- China
- Prior art keywords
- anastomosis staple
- vivo
- magnesium alloy
- biological degradable
- purity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
- C22C23/04—Alloys based on magnesium with zinc or cadmium as the next major constituent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/028—Other inorganic materials not covered by A61L31/022 - A61L31/026
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C1/00—Making non-ferrous alloys
- C22C1/02—Making non-ferrous alloys by melting
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/06—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
Abstract
The present invention relates to tissue engineering technique field more particularly to a kind of biological degradable in vivo anastomosis staple and its production technology, anastomosis staple are composed of the following components by mass percentage：Zn 2 6%, Mn 2 5%, Sn 0.1 1%, Ag 1.5 2%, HA powder 0.5 2%, surplus Mg.A kind of biological degradable in vivo anastomosis staple of the present invention can natural degradation in vivo, can be avoided second operation from internal degradation and cause economy and the burden of body to patient within the regular hour after reaching medical effect；It is avoided in composition design using Al and rare earth metal, the biological safety of material is ensure that from the selection of material；With high corrosion-resistant, good plastic deformation ability and good biocompatibility, meet requirement of the inner implantation material to corrosion rate, and the material, without apparent cytotoxicity, blood compatibility is good, can meet requirement of the inner implantation material to biocompatibility.
Description
Technical field
The present invention relates to tissue engineering technique field more particularly to a kind of biological degradable in vivo anastomosis staple and its production works
Skill.
Background technology
Medical metal material future will occupy an important position in technical field of biological material, this is because medical metal material has
Standby excellent mechanical performance.316L stainless steels, titanium or titanium alloy and Co-Cr alloys etc. have been obtained extensively with excellent mechanical property
General application.But it is the power with biological bone there are a common problem in the existing metal implant material such as stainless steel and titanium alloy
Learn poor compatibility.5 times higher than nature bone of tensile strength of stainless steel, titanium alloy etc. or more, elasticity modulus be even more high 10 times with
On.Very big " stress shielding " effect can be generated to local bone tissue after such material implantation human body.Due to suffered by matrix bone
Stress stimulation declines, and bone remodeling negative balance occurs, bone information is caused to increase, and bon e formation is reduced, and induces blocking property bone loss.Together
When these materials taken, it is necessary to carry out second operation when as provisional implantation material such as intravascular stent, nail, bone plate, spicule
Go out, economy and the burden of body are caused to patient.
To solve the above-mentioned problems, related technical staff researches and develops biodegradable absorbing material, with regard to current
Speech, biodegradable absorbing material are mainly polymer and some ceramic materials, such as polylactic acid, calcium phosphate, but due to mesh
The property of preceding polymer material used in itself influences, as mechanical property is relatively low, processing difficulties, the more acid of decomposition generation in vivo
And easily trigger the problem of inflammation and swelling, limit its application；The plasticity and toughness of ceramic material are poor, and volume is made very with this material
Small vascular stent material is extremely difficult, and rejection rate is high.
Magnesium is biomechanical property and the immediate metal material of human body bone in current all metal materials.The bullet of magnesium alloy
Property be about 45GPa, than the biomaterial titanium alloy (100GPa) that is widely used at present closer to the elasticity modulus of people's bone
(20GPa) can be reduced effectively " stress-shielding effect ", promote symphysis.Magnesium alloy has higher yield strength simultaneously, can
To bear larger load, applied to bone tissue carrying position, endovascular stent can also be applied to, play the work of support blood vessels
With.But there are corrosion resistance is poor, plastic deformation ability force difference for traditional magnesium alloy.Therefore, it is strong, high resistance to develop plastic deformation ability
The biological medical magnesium alloy of corrosion is effectively to reduce its corrosion degradation rate in human body for magnesium alloy is promoted to be cured in biology
The application in field is most important.
Alloying is to improve magnesium alloy plastic deformation ability, improve corrosion stability of magnesium alloy energy, solve its corrosion degradation rate
The effective way of too fast problem.The study found that aluminium, which is added in magnesium alloy, can improve the corrosion resisting property of alloy, play solution strengthening and
Precipitation enhancement, but Al elements can generate health harm, should not be used in biological medical magnesium alloy material.It is in addition, dilute
The addition of earth elements can also significantly improve the corrosion resistance of magnesium alloy, and stress-free corrosion is inclined to, but have been reported that show it is dilute
Earth elements are easily enriched in brain, lack certain biological safety.At present, the more biocompatibility requirement that meets is studied
Complex magnesium alloy has Mg-Mn-Sr-Ca, Mg-Zn-Ca, Mg-Zn-Mn-Ca etc., but the comprehensive performance of these above-mentioned materials is still
Have much room for improvement.
The content of the invention
The purpose of the present invention is be directed to current anastomosis staple material to take into account good plastic deformation ability and higher anti-corrosion
It the problem of property, provides in a kind of organism with high corrosion-resistant, good plastic deformation ability and good biocompatibility
Degradable anastomosis staple and its production technology.
The technical solution adopted by the present invention to solve the technical problems is：
A kind of biology degradable in vivo anastomosis staple, it is composed of the following components by mass percentage：
Zn 2-6%, Mn 2-5%, Sn 0.1-1%, Ag 1.5-2%, HA powder 0.5-2%, surplus Mg.
Preferably, the HA powder is nano bar-shape HA powder, grain size 20-60nm.
Hydroxyapatite（HA）As a kind of ingredient of nature bone, the solubility in human body environment is very low, is closed in magnesium
On the one hand addition in gold can adjust the mechanical performance of magnesium alloy bracket, make the mechanical performance of stent and organism difference portion
The mechanical property of the bone of position matches, and alleviates or avoids stress-shielding effect, the addition of another aspect hydroxyapatite is conducive to
The growth of osteocyte and multiplication can improve the corrosion resisting property of magnesium alloy bracket to a certain extent.The HA selected in the present invention
The HA that the article No. provided for Nanjing Ai Purui nano materials Co., Ltd is MH01.
Preferably, the degree of purity of the Zn is more than 99.99%.
Zinc（Zn）It is alloying element relatively common in a kind of magnesium alloy, the creep-resistant property of casting can be improved, it can be with
Increase the mobility of melt, weak grain refiner to form Micro shrinkage tendency, there is precipitation enhancement.
Preferably, the degree of purity of the Sn is more than 99.99%.
Tin（Sn）The corrosion resistance and intensity of magnesium alloy can be improved.
Preferably, the degree of purity of the Ag is more than 99.99%.
Silver（Ag）Solid solubility maximum in Mg can reach 15%, and after Ag is dissolved in Mg, clearance-type solid solution atom causes non-
Spherical symmetric distorts, so as to generate very strong solid solution strengthening effect and ageing strengthening effect, in magnesium alloy the addition of Ag can compare
The tensile strength and yield strength of alloy are improved more significantly.
Preferably, the degree of purity of the Mg is more than 99.99%.
Preferably, the degree of purity of the Mn is more than 99.99%.
Manganese（Mn）Solid solubility in Mg is small, does not form compound with Mg.Mn with crystal grain thinning, can improve the weldering of alloy
Connect performance.It is but smaller to the invigoration effect of alloy.In other cast magnesium alloys or wrought magnesium alloy, often add in a small amount of
Mn, improve the corrosion resisting property of magnesium alloy.Mn can form high-melting-point chemical combination with the impurity F e of serious damage corrosion stability of magnesium alloy energy
Object and be precipitated out, refine precipitated product, increase creep resistance, improve the corrosion resisting property of alloy.
A kind of production technology of above-mentioned biological degradable in vivo anastomosis staple, comprises the following steps：
1. the preparation process of magnesium alloy：
1）Each component is weighed in proportion；
2）The above-mentioned each component weighed is dried in 100 DEG C of baking oven 1-2 it is small when；
3）Zn, Mn, Sn, Ag and Mg for weighing are added in graphite crucible, after vacuumizing, are passed through BF3And CO2Gaseous mixture
Body after being completely dissolved each component under conditions of 700-800 DEG C, keeps 10-20min as protective gas；
4）HA powder is added to melting has in the graphite crucible of Zn, Mn, Sn, Ag and Mg, and stirs evenly, and it is molten to obtain melting
Liquid；
5）Melting solution is poured into the graphite jig dried in advance, obtains magnesium alloy ingot；
2. the heat treatment process of magnesium alloy：
1）By the magnesium alloy ingot obtained in the preparation process of magnesium alloy when solid solution 10 is small under conditions of 540 DEG C；
2）Magnesium alloy ingot after solid solution is put into the mold preheated in advance, preheating temperature is 220-480 DEG C, in 300-
Section bar, i.e. anastomosis staple are squeezed at a temperature of 500 DEG C；
3）By step 2）In section bar made annealing treatment under conditions of 500 DEG C；
4）To step 3）The section bar of the processing of middle annealing carries out alkali heat-treatment.
Preferably, the base extraction includes the following steps：
1）In NaHCO3-NaOH-Mg(OH)2Solution（pH9.3）It is middle impregnate 24 it is small when, take out natural air drying；
2）10h is kept the temperature in 773K, it is air-cooled.
Advantages of the present invention and advantageous effect are：
(1) a kind of biological degradable in vivo anastomosis staple of the present invention can natural degradation in vivo, reach medical effect
It can be avoided second operation from internal degradation and cause economy and the burden of body to patient within the regular hour after fruit.
(2) a kind of biological degradable in vivo anastomosis staple of the present invention is avoided in composition design using Al and rare earth gold
Belong to, the biological safety of material is ensure that from the selection of material.
(3) a kind of biological degradable in vivo anastomosis staple of the present invention have high corrosion-resistant, good plastic deformation ability and
Good biocompatibility meets requirement of the inner implantation material to corrosion rate, and the material is without apparent cytotoxicity, blood
Liquid phase capacitive is good, can meet requirement of the inner implantation material to biocompatibility.
（4）A kind of biological degradable in vivo anastomosis staple of the present invention uses hydroxyapatite（HA）, on the one hand can adjust magnesium
The mechanical performance of alloy bracket, the mechanical performance and the mechanical property of the bone of organism different parts for making stent match, and alleviate
Or stress-shielding effect is avoided, the opposing party is conducive to growth and the multiplication of osteocyte, can improve magnesium alloy to a certain extent
The corrosion resisting property of stent.
（5）A kind of production technology of biological degradable in vivo anastomosis staple of the present invention, in heat treatment process, is squeezed in section bar
After molded, section bar at 500 DEG C is made annealing treatment, the corrosion resistance of magnesium alloy is improved from inside；At subsequent alkali heat
Manage the corrosion resistance that magnesium alloy is improved from outside.
Specific embodiment
The present invention is described in further detail now.
A kind of biology degradable in vivo anastomosis staple, by mass percentage its component composition see the table below：
A kind of production technology of biology degradable in vivo anastomosis staple, comprises the following steps：
1）Each component is weighed in proportion；
2）The above-mentioned each component weighed is dried in 100 DEG C of baking oven 1-2 it is small when；
3）Zn, Mn, Sn, Ag and Mg for weighing are added in graphite crucible, after vacuumizing, are passed through BF3And CO2Gaseous mixture
Body after being completely dissolved each component under conditions of 700-800 DEG C, keeps 10-20min as protective gas；
4）HA powder is added to melting has in the graphite crucible of Zn, Mn, Sn, Ag and Mg, and stirs evenly, and it is molten to obtain melting
Liquid；
5）Melting solution is poured into the graphite jig dried in advance, obtains magnesium alloy ingot；
2. the heat treatment process of magnesium alloy：
1）By the magnesium alloy ingot obtained in the preparation process of magnesium alloy when solid solution 10 is small under conditions of 540 DEG C；
2）Magnesium alloy ingot after solid solution is put into the mold preheated in advance, preheating temperature is 220-480 DEG C, in 300-
Section bar, i.e. anastomosis staple are squeezed at a temperature of 500 DEG C；
3）By step 2）In section bar made annealing treatment under conditions of 500 DEG C；
4）To step 3）The section bar of the processing of middle annealing is in NaHCO3-NaOH-Mg(OH)2Solution（pH9.3）Middle immersion 24 is small
When, take out natural air drying；
5）By step 4）Obtained section bar keeps the temperature 10h in 773K, air-cooled, obtains biological degradable in vivo anastomosis staple.
Mechanical property, corrosion resistance and cytotoxicity are carried out to the anastomosis staple section bar that each embodiment obtains to test,
Its structure such as following table：
Anastomosis staple provided by the invention not only has good mechanical property, with more excellent corrosion resisting property, solves
Anastomosis staple material cannot take into account good plastic deformation ability and the problem of compared with high corrosion-resistant at present, and catabolite is nontoxic,
Good biocompatibility has larger potential application in biomedical sector.
Using above-mentioned desirable embodiment according to the invention as enlightenment, by above-mentioned description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property scope is not limited to the content on specification, it is necessary to determine its technical scope according to right.
Claims (7)
1. a kind of biology degradable in vivo anastomosis staple, composed of the following components by mass percentage：
Zn 2-6%
Mn 2-5%
Sn 0.1-1%
Ag 1.5-2%
HA powder 0.5-2%
Surplus is Mg；
The production technology of the biological degradable in vivo anastomosis staple, comprises the following steps：
First, the preparation process of magnesium alloy：
1）Each component is weighed in proportion；
2）The above-mentioned each component weighed is dried in 100 DEG C of baking oven 1-2 it is small when；
3）Zn, Mn, Sn, Ag and Mg for weighing are added in graphite crucible, after vacuumizing, are passed through BF3And CO2Mixed gas make
For protective gas, after being completely dissolved each component under conditions of 700-800 DEG C, 10-20min is kept；
4）HA powder is added to melting has in the graphite crucible of Zn, Mn, Sn, Ag and Mg, and stirs evenly, and obtains melting melt；
5）Melting melt is poured into the graphite jig dried in advance, obtains magnesium alloy ingot；
2nd, the heat treatment process of magnesium alloy：
1）By the magnesium alloy ingot obtained in the preparation process of magnesium alloy when solid solution 10 is small under conditions of 540 DEG C；
2）Magnesium alloy ingot after solid solution is put into the mold preheated in advance, preheating temperature is 220-480 DEG C, at 300-500 DEG C
At a temperature of be squeezed into section bar, i.e. anastomosis staple；
3）By step 2）In section bar made annealing treatment under conditions of 500 DEG C；
4）To step 3）The section bar of middle annealing carries out alkali heat-treatment.
2. a kind of biological degradable in vivo anastomosis staple as described in claim 1, it is characterised in that：The HA powder is nano bar-shape
HA powder, grain size 20-60nm.
3. a kind of biological degradable in vivo anastomosis staple as described in claim 1, it is characterised in that：The degree of purity of the Zn exists
More than 99.99%.
4. a kind of biological degradable in vivo anastomosis staple as described in claim 1, it is characterised in that：The degree of purity of the Sn exists
More than 99.99%.
5. a kind of biological degradable in vivo anastomosis staple as described in claim 1, it is characterised in that：The degree of purity of the Ag exists
More than 99.99%.
6. a kind of biological degradable in vivo anastomosis staple as described in claim 1, it is characterised in that：The degree of purity of the Mg exists
More than 99.99%.
7. a kind of biological degradable in vivo anastomosis staple as described in claim 1, it is characterised in that：The degree of purity of the Mn exists
More than 99.99%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610592979.5A CN106086562B (en) | 2016-07-26 | 2016-07-26 | Biological degradable in vivo anastomosis staple and its production technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610592979.5A CN106086562B (en) | 2016-07-26 | 2016-07-26 | Biological degradable in vivo anastomosis staple and its production technology |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106086562A CN106086562A (en) | 2016-11-09 |
| CN106086562B true CN106086562B (en) | 2018-05-29 |
Family
ID=57450285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610592979.5A Active CN106086562B (en) | 2016-07-26 | 2016-07-26 | Biological degradable in vivo anastomosis staple and its production technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106086562B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109280827A (en) * | 2017-07-19 | 2019-01-29 | 北京普润医疗器械有限公司 | Anastomosis staple and its preparation method and application |
| CN110257678B (en) * | 2019-07-29 | 2021-07-16 | 湘潭大学 | High-strength heat-deformation-resistant magnesium alloy material and preparation method thereof |
| CN110343922A (en) * | 2019-08-14 | 2019-10-18 | 西京学院 | A kind of magnesium tin alloy and its preparation method and application that human body is degradable |
| CN111388764A (en) * | 2020-04-03 | 2020-07-10 | 北京联合大学 | Degradable metal anastomosis nail and preparation method thereof |
| EP4163408A4 (en) | 2020-06-05 | 2023-07-26 | Sichuan Megall Medical Devices Co., Ltd | Degradable magnesium alloy in-situ composite staple and preparation method therefor |
| CN112245665A (en) * | 2020-09-28 | 2021-01-22 | 兰州理工大学 | Degradable magnesium alloy anastomosis nail and preparation method thereof |
| CN113476668A (en) * | 2021-07-12 | 2021-10-08 | 中山大学附属第六医院 | Biodegradable anastomosis nail and preparation method thereof |
| CN114086011B (en) * | 2021-10-25 | 2022-07-08 | 江苏理工学院 | Preparation method of component gradient magnesium-based implant material with controllable degradation |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101407879A (en) * | 2008-11-26 | 2009-04-15 | 西南大学 | Yb-containing deformation magnesium alloy and dynamic precipitation strengthening-toughening preparation thereof |
| JP2012025981A (en) * | 2010-07-20 | 2012-02-09 | Sumitomo Electric Ind Ltd | Magnesium alloy coil material |
| CN105349858A (en) * | 2015-11-25 | 2016-02-24 | 中南大学 | Degradable magnesium alloy implanting material for bone fixation and preparing method of degradable magnesium alloy implanting material |
| CN105640601A (en) * | 2016-04-08 | 2016-06-08 | 苏州奥芮济医疗科技有限公司 | In-vivo absorbable metal surgical staple and preparation method thereof |
-
2016
- 2016-07-26 CN CN201610592979.5A patent/CN106086562B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101407879A (en) * | 2008-11-26 | 2009-04-15 | 西南大学 | Yb-containing deformation magnesium alloy and dynamic precipitation strengthening-toughening preparation thereof |
| JP2012025981A (en) * | 2010-07-20 | 2012-02-09 | Sumitomo Electric Ind Ltd | Magnesium alloy coil material |
| CN105349858A (en) * | 2015-11-25 | 2016-02-24 | 中南大学 | Degradable magnesium alloy implanting material for bone fixation and preparing method of degradable magnesium alloy implanting material |
| CN105640601A (en) * | 2016-04-08 | 2016-06-08 | 苏州奥芮济医疗科技有限公司 | In-vivo absorbable metal surgical staple and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 可生物降解医用镁合金的合金化研究进展;王昌等;《材料导报A：综述篇》;20150630;第29卷(第6期);第55-58页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106086562A (en) | 2016-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106086562B (en) | Biological degradable in vivo anastomosis staple and its production technology | |
| JP6431957B2 (en) | Biodegradable metal alloy | |
| US10604827B2 (en) | Biodegradable metal alloys | |
| CN101899600B (en) | Osteopathic magnesium alloy interstitial implant material and preparation method thereof | |
| ES2796371T3 (en) | Magnesium alloy, method for its production and use of it | |
| CN107557632B (en) | Degradable biomedical Mg-Zn-Zr-Nd alloy material and preparation method thereof | |
| US20170218483A1 (en) | Medical biodegradable zn-cu alloy and its preparation method as well as applications | |
| Wang et al. | Research progress of biodegradable magnesium-based biomedical materials: A review | |
| WO2011160533A1 (en) | Magnesium alloy used for degradable implant material of bone in vivo and preparation method thereof | |
| WO2017084363A1 (en) | Medical degradable zn-cu-x alloy material and preparation method thereof | |
| CN102258806B (en) | Degradable magnesium-base biomedical material for implantation in orthopaedics, and preparation method thereof | |
| CN112494725B (en) | Biodegradable composite material and preparation method and application thereof | |
| CN106854724A (en) | A kind of medical magnesium alloy materials containing rare earth element and preparation method thereof | |
| CN108950336B (en) | High-plasticity degradable biomedical Mg-Zn-Zr-Ca-Fe alloy material and preparation method thereof | |
| CN107653410A (en) | Magnesium alloy that biological medical degradable absorbs and its preparation method and application | |
| CN108165782B (en) | Medical zinc-based alloy strip and preparation method thereof | |
| CN108359868A (en) | It is a kind of to be used to be implanted into magnesium alloy of bone and preparation method thereof | |
| CN107198796B (en) | Biomedical Zn-Mn-Cu zinc alloy and preparation method thereof | |
| Niinomi | Recent research and development in metallic materials for biomedical, dental and healthcare products applications | |
| Becerra et al. | Bio-inspired biomaterial Mg–Zn–Ca: A review of the main mechanical and biological properties of Mg-based alloys | |
| CN110512117B (en) | Medical zinc alloy material and preparation method thereof | |
| CN101575682A (en) | Degradable biomedical complex magnesium alloy | |
| CN112426570A (en) | Medical Zn-Cu-Ag-Zr alloy material with high strength and toughness and capable of being degraded in vivo | |
| CN110106413B (en) | Mg-Si-Ca-Zn magnesium alloy and preparation method and application thereof | |
| CN112472868A (en) | Degradable Mg-Nd-Zn-Sc biomedical magnesium alloy and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 213164 West Lake Road, Wujin high tech Zone, Changzhou, Jiangsu, 9 Patentee after: Changzhou Huasen Medical Instrument Co.,Ltd. Address before: 213164 West Lake Road, Wujin high tech Zone, Changzhou, Jiangsu, 9 Patentee before: CHANGZHOU WASTON MEDICAL APPLIANCE Co.,Ltd. |
|
| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: 213000 No.5 Longxiang Road, Nanxiashu street, Wujin national high tech Industrial Development Zone, Changzhou City, Jiangsu Province Patentee after: Changzhou Huasen Medical Instrument Co.,Ltd. Address before: 213164 West Lake Road, Wujin high tech Zone, Changzhou, Jiangsu, 9 Patentee before: Changzhou Huasen Medical Instrument Co.,Ltd. |