CN115299545B - Solid beverage for improving immunity of human body and preparation method thereof - Google Patents
Solid beverage for improving immunity of human body and preparation method thereof Download PDFInfo
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- CN115299545B CN115299545B CN202210968123.9A CN202210968123A CN115299545B CN 115299545 B CN115299545 B CN 115299545B CN 202210968123 A CN202210968123 A CN 202210968123A CN 115299545 B CN115299545 B CN 115299545B
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- powder
- immunity
- solid beverage
- pachyman
- human body
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- 239000007787 solid Substances 0.000 title claims abstract description 73
- 230000036039 immunity Effects 0.000 title claims abstract description 72
- 235000013361 beverage Nutrition 0.000 title claims abstract description 71
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 106
- 239000000843 powder Substances 0.000 claims abstract description 92
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 31
- 229920001184 polypeptide Polymers 0.000 claims abstract description 30
- 241000283690 Bos taurus Species 0.000 claims abstract description 27
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 27
- 150000001875 compounds Chemical class 0.000 claims abstract description 24
- 238000002156 mixing Methods 0.000 claims abstract description 24
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 23
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 23
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- 108010035532 Collagen Proteins 0.000 claims abstract description 18
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 18
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- 230000001954 sterilising effect Effects 0.000 claims abstract description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 30
- 244000197580 Poria cocos Species 0.000 claims description 26
- 239000011259 mixed solution Substances 0.000 claims description 20
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- 238000003756 stirring Methods 0.000 claims description 11
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 10
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 10
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 10
- 239000003094 microcapsule Substances 0.000 claims description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- 235000021388 linseed oil Nutrition 0.000 claims description 8
- 239000000944 linseed oil Substances 0.000 claims description 8
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 claims description 6
- 229940106681 chloroacetic acid Drugs 0.000 claims description 6
- KHQHQJDNEISKKS-UHFFFAOYSA-M sodium;2-chloroacetic acid;hydroxide Chemical compound [OH-].[Na+].OC(=O)CCl KHQHQJDNEISKKS-UHFFFAOYSA-M 0.000 claims description 6
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 claims description 5
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- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 5
- 229930182816 L-glutamine Natural products 0.000 claims description 5
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 claims description 5
- 239000004473 Threonine Substances 0.000 claims description 5
- 235000013345 egg yolk Nutrition 0.000 claims description 5
- 210000002969 egg yolk Anatomy 0.000 claims description 5
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- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- 239000002244 precipitate Substances 0.000 claims description 4
- 229940013618 stevioside Drugs 0.000 claims description 4
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 4
- 235000019202 steviosides Nutrition 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 3
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 11
- 230000004060 metabolic process Effects 0.000 abstract description 8
- 102000004169 proteins and genes Human genes 0.000 abstract description 6
- 108090000623 proteins and genes Proteins 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 5
- 230000002708 enhancing effect Effects 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 22
- 238000012360 testing method Methods 0.000 description 17
- 230000000694 effects Effects 0.000 description 16
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- 210000004698 lymphocyte Anatomy 0.000 description 6
- 238000011056 performance test Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- JYDNKGUBLIKNAM-UHFFFAOYSA-N Oxyallobutulin Natural products C1CC(=O)C(C)(C)C2CCC3(C)C4(C)CCC5(CO)CCC(C(=C)C)C5C4CCC3C21C JYDNKGUBLIKNAM-UHFFFAOYSA-N 0.000 description 4
- FVWJYYTZTCVBKE-ROUWMTJPSA-N betulin Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C FVWJYYTZTCVBKE-ROUWMTJPSA-N 0.000 description 4
- MVIRREHRVZLANQ-UHFFFAOYSA-N betulin Natural products CC(=O)OC1CCC2(C)C(CCC3(C)C2CC=C4C5C(CCC5(CO)CCC34C)C(=C)C)C1(C)C MVIRREHRVZLANQ-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 210000002865 immune cell Anatomy 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 230000000242 pagocytic effect Effects 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
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- 231100000416 LDH assay Toxicity 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000002843 lactate dehydrogenase assay Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003022 colostrum Anatomy 0.000 description 1
- 235000021277 colostrum Nutrition 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000018927 edible plant Nutrition 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 235000021539 instant coffee Nutrition 0.000 description 1
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 235000020162 malted milk drink Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000006996 mental state Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
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- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Non-Alcoholic Beverages (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The application relates to the technical field of solid beverages, in particular to a solid beverage for improving human immunity and a preparation method thereof. The solid beverage for improving the immunity of the human body comprises the following components in parts by weight: 80-120 parts of composite polypeptide, 10-25 parts of pachyman, 10-25 parts of yeast beta-glucan and 30-40 parts of bovine coloctrum powder; the compound polypeptide comprises one or more of tuckahoe peptide powder, bovine bone collagen peptide, ginseng peptide powder and calf thymus peptide powder; the preparation method comprises the following steps: mixing the compound polypeptide, pachyman, yeast beta-glucan and bovine coloctrum powder, drying, sterilizing, and obtaining the solid beverage for improving human immunity. The solid beverage for improving the human immunity has the advantages of promoting the metabolism of the human body, enhancing the efficacy of protein, promoting the absorption of substances, improving the human immunity and resisting fatigue.
Description
Technical Field
The application relates to the technical field of solid beverages, in particular to a solid beverage for improving human immunity and a preparation method thereof.
Background
The solid beverage is a solid product with water content of not higher than 5 g per 100g of finished product, which is prepared by taking sugar, milk or dairy products, egg or egg products, fruit juice or edible plant extracts and the like as main raw materials and adding proper amount of auxiliary materials or food additives, and is in the form of powder, granule or block, such as bean crystal powder, malted milk extract, instant coffee, chrysanthemum crystal and the like. In the past, solid beverages are favored by wide consumers because of various varieties, unique flavor, convenient brewing and easy storage.
However, with the development of society, people are busy and stressed, so that sub-health phenomena of human bodies are common, such as easy fatigue of the bodies, lower immunity and easy occurrence of other diseases. The sub-health state reduces the working efficiency of people and the mental state is poor.
In order to maintain the health of human body, many solid beverages for improving the immunity of human body are available in the market today. However, most of the raw materials in solid beverages are directly mixed and dried. Because the raw materials are not subjected to pre-digestion treatment and are not beneficial to digestion and absorption of human bodies, the solid beverage for improving the human body immunity in the market has no obvious effect on improving the human body immunity.
Disclosure of Invention
In order to improve the immunity of a human body, the application provides a solid beverage for improving the immunity of the human body and a preparation method thereof.
In a first aspect, the present application provides a solid beverage for improving immunity of a human body, which adopts the following technical scheme:
the solid beverage for improving the immunity of the human body comprises the following components in parts by weight:
80-120 parts of composite polypeptide;
10-25 parts of pachyman;
10-25 parts of yeast beta-glucan;
30-40 parts of bovine coloctrum powder;
the compound polypeptide comprises one or more of poria peptide powder, bovine bone collagen peptide, ginseng peptide powder and calf thymus peptide powder.
By adopting the technical scheme, the compound polypeptide, pachyman and yeast beta-glucan are compounded, and because the pachyman peptide powder, bovine bone collagen peptide, ginseng peptide powder or calf thymus peptide powder in the compound polypeptide are all micromolecular peptides with good solubility, bioactivity and easy absorbability, on one hand, various amino acids can be provided for a human body, the novel cell tissues of the human body are helped, the metabolism of the human body is promoted, cytopathy is inhibited, and the immunity of the human body is improved. On the other hand, the functional characteristics of the protein can be improved, the efficacy of the protein is enhanced, the absorption of substances is promoted, and the absorption rate of human bodies on other raw materials such as yeast beta-glucan, pachyman and the like is improved. Therefore, the method improves the phagocytic activity of yeast beta-glucan and pachyman for stimulating and enhancing immune cells such as NK cells, lymphocytes and the like, effectively enhances the toxin removing capability of human bodies, and further improves the immunity of human bodies.
Preferably, the weight ratio of the compound polypeptide to the pachyman to the yeast beta-glucan is 1 (0.15-0.19) to 0.14-0.16.
By adopting the technical scheme, the compound polypeptide, pachyman and yeast beta-glucan are compounded according to the weight ratio, so that the efficacy of protein is enhanced, the human body can absorb nutrient substances in the beverage, the metabolic capacity of the human body is improved, and the immunity is improved.
Preferably, the compound polypeptide is formed by mixing (1-1.4): (0.4-0.8): (0.5-0.9) by weight of tuckahoe peptide powder, bovine bone collagen peptide, ginseng peptide powder and calf thymus peptide powder.
By adopting the technical scheme, the weight ratio of the poria cocos peptide powder, the bovine bone collagen peptide, the ginseng peptide powder and the calf thymus peptide powder is further optimized, so that the oxidation resistance and fatigue resistance of a human body can be improved, the immunity of the human body can be enhanced, the absorption of minerals by the human body can be promoted, the body immunity of the human body can be further improved, and the human body is healthier.
Preferably, the molecular weight of the poria cocos peptide powder, bovine bone collagen peptide, ginseng peptide powder and calf thymus peptide powder is 800-2000Da.
By adopting the technical scheme, the molecular weight of the poria cocos peptide powder, the bovine bone collagen peptide, the ginseng peptide powder and the calf thymus peptide powder is smaller, and the poria cocos peptide powder is favorable for human absorption, so that the absorption rate of human body to yeast beta-glucan and pachyman is improved, the phagocytic activity of immune cells is improved, the toxin removing capability of the human body is effectively enhanced, and the human immunity is further improved.
Preferably, the molecular weight of the poria cocos peptide powder, bovine bone collagen peptide, ginseng peptide powder and calf thymus peptide powder is 1100-1700Da.
By adopting the technical scheme, the poria cocos peptide powder, the bovine bone collagen peptide, the ginseng peptide powder and the calf thymus peptide powder with the molecular weight are mixed, so that the poria cocos peptide powder has a good synergistic compounding effect, and the fatigue resistance of a human body is obviously improved.
Preferably, the solid beverage for improving the immunity of the human body further comprises poria cocos powder and linseed oil microcapsule powder.
By adopting the technical scheme, the poria cocos powder and the linseed oil microcapsule powder are rich in various vitamins, minerals, lecithins and the like, and are compounded with the compound polypeptide, so that the compound polypeptide can promote the human body to absorb the minerals in the poria cocos powder and the linseed oil microcapsule powder, and is beneficial to improving the human body immunity.
Preferably, the pachyman is modified pachyman, and the modified preparation steps are as follows:
a1: adding pachyman into isopropanol, stirring and mixing, and then dropwise adding sodium hydroxide aqueous solution to obtain a mixed solution;
a2: mixing chloroacetic acid with a sodium hydroxide aqueous solution to obtain a chloroacetic acid sodium hydroxide mixed solution;
a3: adding the mixed solution into chloroacetic acid sodium hydroxide mixed solution, stirring and mixing, adjusting the pH value of the mixed solution to 6-7, filtering, collecting precipitate, dialyzing, concentrating and freeze-drying to obtain modified pachyman.
By adopting the technical scheme, pachyman is dissolved and alkali-soluble pachyman is formed by dropwise adding sodium hydroxide aqueous solution. The chloroacetic acid and the sodium hydroxide aqueous solution are mixed in advance to form a mixed solution, then the mixed solution is dripped into the alkali-soluble pachyman, and the chloroacetic acid can be subjected to substitution reaction with the alkali-soluble pachyman under the alkali condition, so that the obtained modified pachyman contains a large number of carboxyl groups, is better in solubility and stronger in antioxidant activity, and is beneficial to enhancing the immunity and fatigue resistance of a human body after being absorbed by the human body.
In a second aspect, the present application provides a method for preparing a solid beverage for improving immunity of a human body, which adopts the following technical scheme:
a preparation method of a solid beverage for improving human immunity comprises the following preparation steps:
mixing the compound polypeptide, pachyman, yeast beta-glucan, bovine coloctrum powder, egg yolk globulin powder, hydroxypropyl methylcellulose, stevioside, taurine, L-threonine, L-cysteine, L-lysine hydrochloride, L-glutamine, glycine, poria cocos powder and linseed oil microcapsule powder, drying, and sterilizing to obtain the solid beverage for improving the human immunity.
By adopting the technical scheme, the preparation method of the solid beverage is simple and is beneficial to mass production. Meanwhile, the product has strong metabolism promoting capability, and can effectively improve the immunity and fatigue resistance of human body.
In summary, the present application has the following beneficial effects:
1. because the compound polypeptide with good solubility, biological activity and easy absorbability is adopted to be compounded with pachyman and yeast beta-glucan, the absorption capacity of pachyman and yeast beta-glucan is improved, the metabolism of a human body is promoted, the phagocytic activity of immune cells is enhanced, and the immunity of the human body is improved;
2. in the application, tuckahoe peptide powder, bovine bone collagen peptide, ginseng peptide powder and calf thymus peptide powder with molecular weight of 800-2000Da are preferably adopted, so that the activity and the transport rate are high, the absorption performance is good, the metabolism of a human body can be further promoted, and the immunity and the fatigue resistance of the human body are improved.
Detailed Description
The present application is described in further detail below with reference to examples.
The solid beverage for improving human immunity obtained in the example and the solid beverage obtained in the comparative example were subjected to an anti-fatigue test and an immunity test, and the detection methods were as follows:
1. grouping and processing: mice with initial body weights ranging from 18-22g were selected and randomized into the example and blank groups of 10 animals each. Example groups were filled with the solid beverage obtained in the example, and blank groups were filled with deionized water. Mice were gavaged once daily for 30 consecutive days according to the gavage standard of 0.02mL/g solid drink.
2. Fatigue resistance test
Experiment 1: mouse load swimming test
After each group of mice was last gavaged for 30min, the tail of the mice was loaded with 5% weight lead wire, and the mice were placed in a swimming box for swimming until the mice were stationary (e.g., tired or tired, for example), the weight-bearing swimming time of each group of mice was measured, and the measurement results were averaged.
3. Immunity test
Experiment 2: conA-induced mouse spleen lymphocyte transformation assay (MTT method)
After 30min of last gastric lavage, animals were sacrificed by cervical dislocation, OD values (optical density values, representing proliferation capacity of lymphocytes) of the example group and the blank group were detected by using an enzyme-labeled analyzer with reference to lymphocyte transformation test (MTT method), and transformation values were calculated as follows:
conversion value = average OD value of example group-average OD value of blank group.
Wherein, the average OD value of the embodiment group is the average value of the statistical results of the embodiment group;
the average OD value of the blank group is the average value of the blank group statistical result;
the transformation values represent the difference in lymphocyte proliferation capacity between the example and blank groups.
Experiment 3: NK cell Activity assay (LDH assay)
After 30min of last gastric lavage, animals were sacrificed by cervical dislocation, and the OD values (optical density values) of the example group and the blank group were measured by using an enzyme-labeled analyzer with reference to NK cell activity assay (LDH assay), and NK cell activity was calculated.
Examples
Example 1
The solid beverage for improving the immunity of the human body is prepared from the following components and corresponding weights shown in table 1:
mixing the compound polypeptide, pachyman, yeast beta-glucan, bovine coloctrum powder, egg yolk globulin powder, hydroxypropyl methylcellulose, stevioside, taurine, L-threonine, L-cysteine, L-lysine hydrochloride, L-glutamine and glycine, and stirring and mixing for 30min under the condition of 35r/min to obtain the solid beverage for improving the immunity of human body.
In the embodiment of the application, the compound polypeptide is pachyman peptide powder, purchased from Woltess biotechnology Co., lanzhou, and the customized molecular weight is 700Da;
pachyman, product number ksm00001;
yeast beta-glucan, cat# 03261613;
bovine colostrum powder with a product number of 0320;
egg yolk globulin powder, protein percent is more than or equal to 80, the total colony count cfu/g is less than or equal to 1000, the content (IgY)% > is more than or equal to 40, the escherichia coli group MPN/100g is less than or equal to 40, the solubility is 99.9%, the moisture is less than or equal to 6% of mold cfu/g is less than or equal to 25;
taurine, L-threonine, L-cysteine, L-lysine hydrochloride, L-glutamine and glycine are all commercially available food grade amino acids.
Examples 2 to 5
A solid beverage for enhancing immunity of human body is different from example 1 in that each component and its corresponding weight are shown in Table 1.
Table 1 Components and weights (kg) of examples 1 to 5
The solid beverages for improving immunity obtained in the above examples 1 to 5 were subjected to an anti-fatigue test and an immunity test, and the test results are shown in Table 2.
Table 2 results of performance tests for examples 1-5
And (3) table notes: example 1 group was filled with the solid beverage obtained in example 1, example 2 group was filled with the solid beverage obtained in example 2, and so on, and the blank group was filled with the same amount of deionized water.
From table 2 above, it is clear that the solid beverages obtained in examples 1 to 5 were sequentially infused in the groups of example 1 to example 5, and the swimming time was longer, the conversion value was higher, and the NK cell activity was stronger than that of the mice in the blank group. Thus, it was revealed that the mice with the solid beverages obtained in examples 1 to 5 were better in physical strength and were better in lymphocyte proliferation ability, and thus had better anti-fatigue ability and immunity ability.
Among them, in the group of example 1-example 5, the mice of the group of example 2-example 4 were longer in swimming time, higher in transformation value, and stronger in NK cell activity. The analysis is possible because the weight ratio of the compound polypeptide to the pachyman to the yeast beta-glucan in the total raw materials of the solid beverage is 1 (0.15-0.19) (0.14-0.16), the metabolism of human cells is promoted, the absorptivity of the human body to the yeast beta-glucan and the pachyman is improved, and the fatigue resistance and the immunity of the human body are improved.
Examples 6 to 10
A solid beverage for improving immunity of human body is different from example 3 in that each component and its corresponding weight in the composite polypeptide are shown in Table 3.
Table 3 the components and weights (kg) thereof in examples 6 to 10
In examples 6-10 above, bovine bone collagen peptide and ginseng peptide powder were purchased from texas blue biotechnology limited and the molecular weight was custom made to be 700Da;
calf thymus peptide powder with main nutrition component thymus peptide, effective substance content of 99%, and molecular weight of 700Da purchased from Sichuan green gallop biotechnology Co., ltd;
the solid beverages for improving immunity obtained in examples 6 to 10 were subjected to an anti-fatigue test and an immunity test, and the test results are shown in Table 4.
TABLE 4 results of performance tests for examples 6-10
From Table 4 above, it is understood that the solid beverages obtained in examples 6 to 10 were sequentially filled in the stomach from the group of example 6 to the group of example 10, and the swimming time, the transformation value and the NK cell activity were significantly increased as compared to the mice of the group of example 3 and the blank group. Therefore, the compound polypeptide is formed by mixing the poria cocos peptide powder, the bovine bone collagen peptide, the ginseng peptide powder and the calf thymus peptide powder in the total raw materials of the solid beverage, so that the anti-fatigue capability and the immunity capability of the mice are higher.
Among them, in the group of example 6-the group of example 10, the mice of the group of example 6-the group of example 8 were longer in swimming time, higher in transformation value and stronger in NK cell activity. Therefore, in the total raw materials of the solid beverage, the compound polypeptide is formed by mixing (1-1.4): (0.4-0.8): (0.5-0.9) by weight of tuckahoe peptide powder, bovine bone collagen peptide, ginseng peptide powder and calf thymus peptide powder, and the anti-fatigue capability and the immunity capability of the mice can be further improved.
Examples 11 to 15
A solid beverage for improving immunity of human body is different from example 7 in that each component in the composite polypeptide and its corresponding molecular weight are shown in Table 5.
TABLE 5 molecular weights (Da) of the Components in examples 11-15
In examples 11 to 15, the poria cocos peptide powder, bovine bone collagen peptide, ginseng peptide powder and calf thymus peptide powder were prepared in the same manner as in example 7, and the molecular weights were customized.
The solid beverages for improving immunity obtained in examples 11 to 17 were subjected to an anti-fatigue test and an immunity test, and the test results are shown in Table 6.
Table 6 results of Performance measurements in examples 11-17
As is clear from Table 6 above, the solid beverages obtained in examples 11 to 15 were sequentially filled in the stomach from example 11 to example 15, and the swimming time was significantly increased, and the transformation value and NK cell activity were not greatly changed, compared to the mice in example 7 and the blank. Therefore, the total raw materials of the solid beverage show that the molecular weight of the poria cocos peptide powder, the bovine bone collagen peptide, the ginseng peptide powder and the calf thymus peptide powder is 800-2000Da, and the anti-fatigue capability of mice is stronger.
Among them, in the group of example 11 to the group of example 15, the swimming time of the mice of the group of example 12 to the group of example 14 was longer. Therefore, in the total raw materials of the solid beverage, the molecular weights of the poria cocos peptide powder, the bovine bone collagen peptide, the ginseng peptide powder and the calf thymus peptide powder are 1100-1700Da, so that the anti-fatigue capability of mice can be further improved.
Example 16
The solid beverage for improving immunity of human body is different from example 13 in that pachyman is further modified, and the modification steps are as follows:
a1: mixing 0.2kg pachyman and 2L isopropanol, soaking at 35deg.C for 12 hr, dripping 0.5L sodium hydroxide aqueous solution with mass concentration of 25% at 0-5deg.C, and ultrasonic stirring at 40kHz for 30min to obtain mixed solution.
A2: mixing 0.2kg of chloroacetic acid and 0.5L of 35% sodium hydroxide aqueous solution by mass concentration to obtain chloroacetic acid sodium hydroxide mixed solution;
a3: adding the mixed solution into chloroacetic acid sodium hydroxide mixed solution, stirring and mixing for 10 hours at 55 ℃, then adjusting the pH value of the mixed solution to 6, filtering, collecting precipitate, dialyzing again to obtain a molecular weight cutoff value of 2800Da, concentrating and freeze-drying again to obtain the modified pachyman with the molecular weight of 2800 Da.
Example 17
A solid beverage for improving immunity of human body, which is different from example 16 in that the modified treatment of pachyman comprises the following steps:
a1: after 0.2kg of pachyman and 2L of isopropanol are mixed, 0.5L of sodium hydroxide aqueous solution with mass concentration of 25% is dripped at 0-5 ℃, and stirring and mixing are carried out for 30min under the condition of 2000r/min, thus obtaining a mixed solution.
A3: adding 0.2kg of chloroacetic acid into the mixed solution, stirring and mixing for 10min, adding 0.5L of 35% sodium hydroxide aqueous solution for mixing, stirring and mixing for 10h at 55 ℃, adjusting the pH value of the mixed solution to 6, filtering, collecting precipitate, dialyzing again to obtain a molecular weight cutoff value of 2800Da, concentrating and drying again to obtain the modified pachyman with the molecular weight of 2800 Da.
The solid beverages for improving immunity obtained in examples 16 to 17 were subjected to an anti-fatigue test and an immunity test, and the test results are shown in Table 7.
Table 7 results of performance tests in example 16
From Table 7 above, it is understood that the solid beverage obtained in example 16, which was the gastric lavage of example 16, was significantly increased in swimming time, transformation value and NK cell activity compared to the mice in example 13 and the blank group. Therefore, the modified pachymaran is added into the total raw materials of the solid beverage, so that the metabolism of the human body can be promoted, cytopathy can be inhibited, and the immunity of the human body can be improved.
The solid beverage obtained in example 16, group 16 was gavaged, and the swimming time, transformation value and NK cell activity were significantly increased compared to the mice in example 17 group. Therefore, the self-made modified pachyman has higher activity and oxidation resistance, and is beneficial to improving the immunity of human bodies.
Example 18
The solid beverage for improving the immunity of the human body is different from the solid beverage in the embodiment 16 in that 5kg of poria cocos powder and 5kg of linseed oil microcapsule powder are also added into the total raw materials of the solid beverage for improving the immunity of the human body; wherein, the tuckahoe powder is SY-YC037, the linseed oil microcapsule powder is CT141.
The solid beverage for improving the immunity of the human body is prepared by the following steps:
mixing the compound polypeptide, pachyman, yeast beta-glucan, bovine coloctrum powder, egg yolk globulin powder, hydroxypropyl methylcellulose, stevioside, taurine, L-threonine, L-cysteine, L-lysine hydrochloride, L-glutamine, glycine, poria cocos powder and linseed oil microcapsule powder, and stirring and mixing for 30min under the condition of 35r/min to obtain the solid beverage for improving the immunity of the human body.
The solid beverage for improving immunity obtained in example 18 was subjected to an anti-fatigue test and an immunity test, and the test results are shown in table 8.
Table 8 results of performance tests in example 18
Comparative example
Comparative example 1
A solid beverage is different from example 3 in that an equivalent amount of betulin is used instead of the compound polypeptide; wherein the molecular weight of the betulin is 700Da.
Comparative example 2
A solid beverage differing from example 3 in that equal amounts of dendrobe polysaccharide were used instead of pachyman; wherein, the dendrobe polysaccharide has a commodity number of ksm000001.
Comparative example 3
A solid beverage differs from example 3 in that an equivalent amount of the complex polypeptide is used instead of yeast beta-glucan.
The solid beverages for improving immunity obtained in the above comparative examples 1 to 3 were subjected to an anti-fatigue test and an immunity test, and the test results are shown in Table 8.
Table 8 results of the performance tests of comparative examples 1 to 3
And (3) table notes: example 3 group gavage the solid beverage obtained in example 3, comparative example 1 group gavage the solid beverage obtained in comparative example 1, and so on, the blank group was equally gavaged with deionized water.
Comparing example 3 with comparative examples 1-3, the swimming time of the mice of example 1 group was relatively increased by 7.48-11.99%, the conversion value was relatively increased by 30.30-49.57%, and the NK cell activity was relatively increased by 11.88-17.05%. Therefore, in the solid beverage total raw materials for improving the human immunity, the compound polypeptide, the poria cocos powder and the yeast beta-glucan are adopted for compounding, so that the metabolism of the human body can be promoted, the efficacy of protein is enhanced, the absorption of substances is promoted, and the immunity and the anti-fatigue capability of the human body are improved.
Although the solid beverage of comparative example 1 uses the betulin having a molecular weight of 700D, the absorption performance of the betulin by the human body is good. However, the swimming time, transformation value and NK cell activity of the solid drink mice perfused in comparative example 1 were all lower than those of the solid drink perfused in example 3 of the present application. The analysis of the reasons is probably that the compound polypeptide has a certain synergistic effect with the poria cocos powder and the yeast beta-glucan, so that the immunity and the fatigue resistance of the human body are improved.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (5)
1. The solid beverage for improving the immunity of the human body is characterized by comprising the following components in parts by weight:
80-120 parts of composite polypeptide;
10-25 parts of pachyman;
10-25 parts of yeast beta-glucan;
30-40 parts of bovine coloctrum powder;
the compound polypeptide is formed by mixing (1-1.4): (0.4-0.8): (0.5-0.9) by weight of tuckahoe peptide powder, bovine bone collagen peptide, ginseng peptide powder and calf thymus peptide powder;
the molecular weight of the poria cocos peptide powder, bovine bone collagen peptide, ginseng peptide powder and calf thymus peptide powder is 1100-1700Da.
2. The solid beverage for improving immunity according to claim 1, wherein the weight ratio of the compound polypeptide to pachyman to yeast beta-glucan is 1 (0.15-0.19): 0.14-0.16.
3. The solid beverage for improving immunity of human body according to claim 1, further comprising Poria powder and oleum Lini microcapsule powder.
4. The solid beverage for improving immunity of human body according to claim 1, wherein the pachyman is modified pachyman, and the modified preparation steps are as follows:
a1: adding pachyman into isopropanol, stirring and mixing, and then dropwise adding sodium hydroxide aqueous solution to obtain a mixed solution;
a2: mixing chloroacetic acid with a sodium hydroxide aqueous solution to obtain a chloroacetic acid sodium hydroxide mixed solution;
a3: adding the mixed solution into chloroacetic acid sodium hydroxide mixed solution, stirring and mixing, adjusting the pH value of the mixed solution to 6-7, filtering, collecting precipitate, dialyzing, concentrating and freeze-drying to obtain modified pachyman.
5. The method for preparing the solid beverage for improving the immunity of the human body according to claim 1, which is characterized by comprising the following preparation steps:
mixing the compound polypeptide, pachyman, yeast beta-glucan, bovine coloctrum powder, egg yolk globulin powder, hydroxypropyl methylcellulose, stevioside, taurine, L-threonine, L-cysteine, L-lysine hydrochloride, L-glutamine, glycine, poria cocos powder and linseed oil microcapsule powder, drying and sterilizing to obtain the solid beverage for improving the human immunity.
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| CN106070959A (en) * | 2016-07-06 | 2016-11-09 | 安徽米乐食品有限公司 | A kind of nourishing healthy toffee of immunity of organisms of replenishing the calcium, improve |
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| CN109221864A (en) * | 2018-08-28 | 2019-01-18 | 杭州千岛湖标普健康食品有限公司 | A kind of functional solid beverage and preparation method thereof that the multicomponent enhanced human immunity is compound |
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