CN115282235A - Traditional Chinese medicine compound and compound granules for clearing away heat and toxic materials and preparation method thereof - Google Patents
Traditional Chinese medicine compound and compound granules for clearing away heat and toxic materials and preparation method thereof Download PDFInfo
- Publication number
- CN115282235A CN115282235A CN202210590001.0A CN202210590001A CN115282235A CN 115282235 A CN115282235 A CN 115282235A CN 202210590001 A CN202210590001 A CN 202210590001A CN 115282235 A CN115282235 A CN 115282235A
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- parts
- chinese medicine
- traditional chinese
- compound
- clearing away
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Abstract
The invention discloses a traditional Chinese medicine compound for clearing away heat and toxic materials, which comprises the following medicinal materials in parts by weight: 15-25 parts of Chinese yam, 7-13 parts of poria cocos, 25-35 parts of honeysuckle, 15-25 parts of houttuynia cordata, 15-25 parts of reed rhizome, 12-18 parts of ageratum, 4-6 parts of wolfberry and 7-13 parts of liquorice. The invention also discloses a traditional Chinese medicine compound granule for clearing away heat and toxic materials, which comprises the following raw materials: dextrin and the Chinese medicinal compound for clearing away heat and toxic materials. The invention also discloses a preparation method of the traditional Chinese medicine compound granule for clearing away heat and toxic materials, which comprises the following steps: decocting rhizoma Dioscoreae, poria, flos Lonicerae, herba Houttuyniae, rhizoma Phragmitis, herba Agastaches, fructus Lycii and Glycyrrhrizae radix with water to obtain water decoction, concentrating the water decoction to obtain extract A, spray drying the extract A and dextrin, and granulating to obtain the Chinese medicinal compound granule with heat and toxic materials clearing away effects. The invention realizes the effects of strengthening body resistance and eliminating evil, clearing heat and detoxicating by the mutual compatibility of monarch, minister, assistant and guide medicines so as to improve the immunity of the organism and enhance the antiviral ability.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine compound and preparation, in particular to a traditional Chinese medicine compound and compound granules for clearing away heat and toxic materials and a preparation method thereof.
Background
Aiming at the prevention and treatment of virus infectious diseases, the western medicine therapy has the problems of vaccine lag, virus variability, western medicine drug resistance and the like. The traditional Chinese medicine compound has the characteristics of multiple components, multiple targets, multiple effects, small side effect, difficulty in generating drug resistance and the like, can play a role through multiple targets and multiple ways, and plays an increasingly greater role in treating viral infectious diseases.
Aiming at the prevention and treatment problems of virus infectious diseases, the invention provides a novel traditional Chinese medicine compound and compound granules consisting of medicinal and edible traditional Chinese medicinal materials and a preparation method thereof based on the prevention and treatment concept of 'prevention before illness, body resistance strengthening and evil eliminating' of the basic theory of traditional Chinese medicine.
Disclosure of Invention
Based on the technical problems in the background art, the invention provides a traditional Chinese medicine compound and compound granules for clearing away heat and toxic materials and a preparation method thereof.
The invention provides a traditional Chinese medicine compound for clearing away heat and toxic materials, which comprises the following medicinal materials in parts by weight: 15-25 parts of Chinese yam, 7-13 parts of poria cocos, 25-35 parts of honeysuckle, 15-25 parts of houttuynia cordata, 15-25 parts of reed rhizome, 12-18 parts of ageratum, 4-6 parts of medlar and 7-13 parts of liquorice.
Preferably, the formula comprises the following medicinal materials in parts by weight: 20 parts of Chinese yam, 10 parts of poria cocos, 30 parts of honeysuckle, 20 parts of houttuynia cordata, 20 parts of reed rhizome, 15 parts of ageratum, 5 parts of wolfberry and 10 parts of liquorice.
According to the traditional Chinese medicine thought of 'three deficiency' caused epidemic and the prevention and treatment concept of 'strengthening body resistance and eliminating evil' and 'preventing and treating before disease' proposed in 'Huangdi' Nei Jing, su Wen Yi (article of ancient folk research), under the guidance of the traditional Chinese medicine basic theory, eight traditional Chinese medicines of honeysuckle, tuckahoe, wrinkled gianthyssop herb, cordate houttuynia, reed rhizome and liquorice which are homologous in medicine and food are selected for composing prescriptions and compatibility.
Yam, rhizoma Dioscoreae, sweet and neutral, is good at tonifying qi and yin, so it is said from Shen nong Ben Cao Jing that it is effective in treating injury, tonifying deficiency and win, dispelling cold and heat, eliminating pathogenic factors, tonifying middle-jiao and invigorating qi, growing muscle, improving hearing and eyesight, reducing weight and not hunger, and prolonging life.
Poria has mild property, sweet and bland taste, and has effects of invigorating spleen, calming heart, inducing diuresis and eliminating dampness.
In the formula, the Chinese yam and the tuckahoe are monarch drugs which have the effects of tonifying qi and strengthening spleen, eliminating dampness in time, clearing hollow viscera and discharging turbidity and assisting the body to strengthen vital qi; the honeysuckle, the heartleaf houttuynia herb and the reed rhizome all have the functions of clearing heat and removing toxicity and are used as ministerial drugs; in the formula, the agastache rugosus is fragrant and dampness is removed, and the medlar is capable of replenishing vital essence and nourishing blood, and moistening lung to arrest cough, and is an adjuvant drug; gancao, which enjoys the name of "Gulao", regulates the middle warmer and relieves urgency, can coordinate the effects of the drugs, relieve various toxicities, and replenish qi to invigorate the spleen, and is used as a guiding drug. The whole formula emphasizes that the invention strengthens body resistance to eliminate pathogenic factors, clears away heat and toxic materials, can benefit the organism and improve immunity and enhances antiviral ability.
The Chinese medicinal compound for clearing away heat and toxic materials can also contain medicinal adjuvants such as filler, dispersant, lubricant, etc.
Preferably, the Chinese herbal compound preparation is a granule, a decoction, a capsule, a tablet or a sustained-release preparation.
The invention also provides a traditional Chinese medicine compound granule for clearing away heat and toxic materials, which comprises the following raw materials: dextrin and the Chinese medicinal compound prescription for clearing away heat and toxic materials.
In order to improve the drug loading rate and stability, the traditional Chinese medicine compound is prepared into granules, so that the traditional Chinese medicine compound has the advantages of quick absorption, quick response, and convenient taking, carrying and storage stability.
In the preparation process of the traditional Chinese medicine granules, sucrose, starch and the like are generally selected as auxiliary materials. However, sucrose is hygroscopic, easily softened and deteriorated, starch is sticky, and meanwhile, the sugar-containing preparation is not suitable for patients with diabetes, hypertension, obesity and the like. The invention selects dextrin with smaller viscosity than starch as auxiliary material, and combines proper preparation process, so that the granule has better granule shape, good forming rate, fluidity and granule dissolubility, and can reduce hygroscopicity.
The granules prepared by the invention are beautiful and wear-resistant, have high forming rate and good fluidity, and meet the requirements of 2020 edition of Chinese pharmacopoeia on the granules.
The invention also discloses a preparation method of the traditional Chinese medicine compound granule for clearing away heat and toxic materials, which comprises the following steps: decocting rhizoma Dioscoreae, poria, flos Lonicerae, herba Houttuyniae, rhizoma Phragmitis, herba Agastaches, fructus Lycii and Glycyrrhrizae radix with water to obtain water decoction, concentrating the water decoction to obtain extract A, spray drying the extract A and dextrin, and granulating to obtain the Chinese medicinal compound granule with heat and toxic materials clearing away effects.
Preferably, the density of the extract A is 1.1-1.3g/ml.
Preferably, the weight ratio of the extract A to the dextrin is 4-8.
The invention uses a small amount of dextrin and combines a proper process, so that the granules have better granule shape, forming rate and granule dissolubility.
Preferably, during spray drying, the temperature of the extract A is increased to 65-75 ℃.
Preferably, the air inlet temperature of the spray drying is 100-110 ℃, and the air outlet temperature is 60-70 ℃.
Preferably, the atomization pressure of the spray drying is 1.5-2.5MPa, and the spray speed is 30-40Hz.
Preferably, the water is decocted and extracted for 1-3 times, the extraction time is 0.5-1.5h each time, and the water consumption for each time is 8-12 times of the total weight of the Chinese yam, the tuckahoe, the honeysuckle, the heartleaf houttuynia herb, the reed rhizome, the ageratum, the medlar and the liquorice.
Preferably, the water extraction is carried out for 3 times, the time of each water extraction is 0.5h, and the water consumption of each water extraction is 12 times of the total weight of the Chinese yam, the tuckahoe, the honeysuckle, the houttuynia cordata, the reed rhizome, the ageratum, the medlar and the liquorice.
In order to avoid the volatilization loss of the components in the houttuynia cordata and the ageratum, the houttuynia cordata and the ageratum are added at last, and a proper adding time is screened out.
Preferably, the herba Houttuyniae and herba Agastaches are added after decocting with water, and the herba Houttuyniae and herba Agastaches are added 5-15min before decocting and decocting.
The invention selects a proper extraction process, so that the invention has higher cream yield, chlorogenic acid content and ferulic acid content at the same time.
Has the beneficial effects that:
according to the traditional Chinese medicine thought of ' three deficiency ' caused epidemic and the prevention and treatment ideas of ' strengthening body resistance and eliminating evil ' and ' preventing and treating before disease ' proposed in ' Huangdi ' inner channel and element question legacy chapter, we advocate to strengthen the body's healthy qi to penetrate through to eliminate the fierce qi. Under the guidance of the traditional Chinese medicine basic theory, the invention selects eight kinds of Chinese medicines of honeysuckle, tuckahoe, agastache rugosus, houttuynia cordata, reed rhizome and liquorice which are homologous in medicine and food to carry out prescription compatibility according to the basic thought of homology of medicine and food.
The yam and the tuckahoe, as monarch drugs, can tonify qi and spleen, eliminate dampness in time, clear hollow organs and discharge turbidity, and can help the body to strengthen vital qi; the honeysuckle, the heartleaf houttuynia herb and the reed rhizome all have the functions of clearing away heat and toxic materials and are used as ministerial drugs; in the formula, the ageratum is fragrant and dampness-resolving, and the medlar is capable of replenishing vital essence and nourishing blood, moistening lung and relieving cough, and the ageratum and the medlar are adjuvant drugs; the liquorice enjoying the name of the aged harmonizes the middle warmer and relieves urgency, can regulate the effects of the medicines, can relieve various toxins, and can replenish qi and invigorate the spleen, thus serving as a guiding medicine; the whole formula emphasizes that the invention strengthens body resistance to eliminate pathogenic factors, clears away heat and toxic materials, can benefit the organism and improve the immunity and enhance the antiviral ability.
In addition, the invention selects proper auxiliary materials and combines proper granulating process, so that the granules have good granule shape, forming rate, fluidity and granule dissolubility, low hygroscopicity and accord with the requirement of 2020 edition Chinese pharmacopoeia on granules.
Drawings
Fig. 1 is a typical spectrum of the high performance liquid chromatography in example 6, wherein a is an HPLC chromatogram of a mixed reference substance of chlorogenic acid and ferulic acid, B is an HPLC chromatogram of the prepared dry paste powder, and peak 1 is a characteristic peak of chlorogenic acid and peak 2 is a characteristic peak of ferulic acid.
FIG. 2 is a photograph of particles prepared from groups a-c in example 7, wherein a is group a, b is group b, and c is group c.
Detailed Description
Hereinafter, the technical solution of the present invention will be described in detail by specific examples, but these examples should be explicitly proposed for illustration, but should not be construed as limiting the scope of the present invention.
The instrument and material information is as follows:
a T2003 electronic balance (Hangzhou Wante weighing apparatus Co., ltd.), a WB-2000 constant temperature water bath (Zhengzhou Changcheng Kogao Co., ltd.), a DZF-6050 type vacuum drying oven (Shanghai Bocheng Chengyi Co., ltd.), an RXH-7C hot air circulation oven (Nanjing Xuan Jamo pharmaceutical equipments Co., ltd.), a PGL-5B spray granulator (Changzhou Shahua drying equipments Co., ltd.), and an Alliance Waters1525 high performance liquid chromatograph (Watts Co., USA).
Chlorogenic acid standard (batch: 026Y-PD4V, institute for testing and testing Chinese food and drug), and ferulic acid standard (batch: DSTDF008101, lemeitian medicine/Designant biology).
Chinese yam, tuckahoe, honeysuckle, heartleaf houttuynia herb, reed rhizome, liquorice, patchouli and medlar (purchased from Anhui Huaxiu pharmaceutical industry Co., ltd.) and are identified by experts. The rhizoma Dioscoreae is dried rhizome of Dioscorea opposita thumb of Dioscoreaceae; poria cos (Schw.) Wolf is dry sclerotium of Poria cocos (Schw.) Wolf of Polyporaceae family; the flos Lonicerae is dried bud or flower with initial bloom of Lonicera japonica Thunb of Caprifoliaceae; the herba Houttuyniae Houttuynia cordiata Thunb is dried aerial part of Houttuynia cordata Thunb of Saururaceae; the rhizoma Phragmitis is dried rhizome of Phragmitis communis Trin of Gramineae; the Glycyrrhrizae radix is dried root and rhizome of Glycyrrhiza uralensis Fisch of Leguminosae; pogostemon cablin is dry aerial part of Pogostemon cablin (Blanco) Benth, belonging to Labiatae; the fructus Lycii is dried mature fruit of Lycium barbarum L.
Chromatographic grade methanol (batch No.: 21110106G401, european Preson Limited, sweden); chromatographic grade acetonitrile (batch: SHBM1775, merck, USA), other chemical reagents were analytically pure.
Example 1
A traditional Chinese medicine compound for clearing away heat and toxic materials comprises the following medicinal materials in parts by weight: 15g of Chinese yam, 7g of poria cocos, 25g of honeysuckle, 15g of houttuynia cordata, 15g of reed rhizome, 12g of ageratum, 4g of wolfberry and 7g of liquorice.
Example 2
A traditional Chinese medicine compound for clearing away heat and toxic materials comprises the following medicinal materials in parts by weight: 25g of Chinese yam, 13g of poria cocos, 35g of honeysuckle, 25g of houttuynia cordata, 25g of reed rhizome, 18g of ageratum, 6g of Chinese wolfberry and 13g of liquorice.
Example 3
A traditional Chinese medicine compound for clearing away heat and toxic materials comprises the following medicinal materials in parts by weight: 18g of Chinese yam, 9g of poria cocos, 28g of honeysuckle, 18g of houttuynia cordata, 18g of reed rhizome, 14g of ageratum, 4.5g of wolfberry and 9g of liquorice.
Example 4
A traditional Chinese medicine compound for clearing away heat and toxic materials comprises the following medicinal materials in parts by weight: 22g of Chinese yam, 11g of poria cocos, 32g of honeysuckle, 22g of houttuynia cordata, 22g of reed rhizome, 16g of ageratum, 5.5g of wolfberry and 11g of liquorice.
Example 5
A traditional Chinese medicine compound for clearing away heat and toxic materials comprises the following medicinal materials in parts by weight: 20g of Chinese yam, 10g of poria cocos, 30g of honeysuckle, 20g of houttuynia cordata, 20g of reed rhizome, 15g of ageratum, 5g of wolfberry and 10g of liquorice.
Example 6
According to the formula of the embodiment 5, eight medicinal materials including Chinese yam, poria cocos, honeysuckle, houttuynia cordata, reed rhizome, ageratum, wolfberry and liquorice are accurately weighed, the eight medicinal materials are fully soaked in water and then decocted and extracted, the houttuynia cordata and the ageratum are added 10min before the decoction is finished and are continuously decocted until the decoction is finished, dregs are removed through filtration to obtain water decoction, and the water decoction is subjected to reduced pressure concentration and drying to obtain dry paste powder.
Because the honeysuckle and the heartleaf houttuynia herb all contain chlorogenic acid monomer components, the chlorogenic acid has pharmacological actions of antibiosis, antivirus, antiphlogosis and the like, and is an important index of a quality control system of a plurality of medicinal materials and a Chinese medicine compound; the active component of ferulic acid contained in rhizoma phragmitis has broad-spectrum antibacterial effect, and can remarkably inhibit cold virus and respiratory syncytial virus; therefore, the inventor takes the cream yield, the chlorogenic acid content and the ferulic acid content as indexes and inspects the quality of the dry cream powder obtained under different extraction parameters. The results are shown in table 2 and fig. 1.
Fig. 1 is a typical chromatogram of the high performance liquid chromatography in example 6, wherein a is an HPLC chromatogram of a mixed reference of chlorogenic acid and ferulic acid, B is an HPLC chromatogram of the prepared dry paste powder, peak 1 is a characteristic peak of chlorogenic acid, and peak 2 is a characteristic peak of ferulic acid.
Detecting the content of chlorogenic acid and the content of ferulic acid in the dry paste powder by adopting a high performance liquid chromatography, wherein the specific detection conditions are as follows: the chromatographic column is Thermo Acclaim TM 120-C18 (4.6X 250mm,5 μm); the flow rate is 1.0 mL/min -1 The detection wavelength is 325nm, the column temperature is 30 ℃, and the sample injection amount is 10 mu L; the mobile phase A is acetonitrile, the mobile phase B is phosphoric acid water solution with the volume fraction of 0.1 percent, and the gradient elution conditions are shown in the table 1.
TABLE 1 gradient elution conditions
| Time (min) | Mobile phase A (v/v%) | Mobile phase B (v/v%) |
| 0 | 12 | 88 |
| 15 | 25 | 75 |
| 35 | 25 | 75 |
TABLE 2 detection results of dry extract powder obtained by different extraction parameters
Remarking: the weight of the water added each time is based on the total weight of the Chinese yam, the tuckahoe, the honeysuckle, the heartleaf houttuynia herb, the reed rhizome, the ageratum, the medlar and the liquorice.
As can be seen from Table 2, the extraction times are 3 times, the times of adding water each time are 12, and the decoction time is 0.5h each time, so that the cream yield, the chlorogenic acid content and the ferulic acid content are high.
Example 7
Dividing 5g of dry extract powder prepared by the sequence number 3 in the embodiment 6 into 5 groups, preparing 1g of each group into extract A with certain density by using water, adjusting the temperature of the extract A to 65-75 ℃, and carrying out spray drying on the extract A and dextrin in a fluidized bed spray granulator to obtain the heat-clearing and detoxifying traditional Chinese medicine compound granules, wherein the air inlet temperature of the spray drying is 100-110 ℃, the air outlet temperature is 60-70 ℃, the atomization pressure is 1.5-2.5MPa, and the spray speed is 30-40Hz.
The influence of different dextrin dosages and different extract A densities on the particle properties is examined, and the results are shown in table 3 and fig. 2.
FIG. 2 is a photograph of particles prepared from groups a-c in example 7, wherein a is group a, b is group b, and c is group c.
TABLE 3 granular properties obtained with different dextrin dosages and different extract A densities
As can be seen from Table 3 and FIG. 2, when the density of extract A is 1.1-1.3g/ml and the amount of dextrin is 1g (i.e. the weight ratio of extract A to dextrin is 4-8.
Example 8
A traditional Chinese medicine compound granule for clearing heat and removing toxicity comprises the following steps:
accurately weighing Chinese yam, poria cocos, honeysuckle, houttuynia cordata, reed rhizome, ageratum, medlar and liquorice according to the formula in the embodiment 5, adding water to soak the Chinese yam, poria cocos, honeysuckle, reed rhizome, ageratum, medlar and liquorice, fully soaking the Chinese yam, poria cocos, honeysuckle, houttuynia cordata, reed rhizome, ageratum, medlar and liquorice, decocting for 3 times, wherein the water consumption is 12 times of the total weight of the Chinese yam, poria cocos, honeysuckle, houttuynia cordata, reed rhizome, ageratum, medlar and liquorice each time, and the decocting time is 0.5h each time, wherein the Chinese yam, the poria cocos, the honeysuckle, the houttuynia cordata, the reed rhizome, the ageratum, the medlar and the liquorice are added after the decoction, the decoction is filtered and deslagged after the decoction is finished, so that water decoction is obtained, the water decoction is combined for 3 times, and the water decoction is decompressed and concentrated to obtain an extract A with the density of 1.2 g/mL; and (3) adjusting the temperature of the extract A to 70 ℃, and performing spray drying together with dextrin to obtain the heat-clearing and detoxifying traditional Chinese medicine compound granules, wherein the air inlet temperature of the spray drying is 105 ℃, the air outlet temperature is 65 ℃, the atomization pressure is 2.0MPa, the spraying speed is 35Hz, and the weight ratio of the extract A to the dextrin is 6.
Following the procedure of example 8, 3 groups of granules were prepared in parallel and the granules were examined for particle size, moisture and angle of repose. The results are shown in Table 4.
TABLE 4 test results
| Grouping | Particle size% | Water content (%) | Angle of repose (°) |
| 1 | 3.28 | 3.1341 | 28.41 |
| 2 | 3.04 | 3.5359 | 29.19 |
| 3 | 3.22 | 3.0675 | 28.91 |
Remarking: 1. the particle size detection refers to the requirement that the sum of the particle size detection which can not pass through the first sieve and the particle size detection which can pass through the fifth sieve cannot exceed 15 percent of the amount to be measured in the preparation process of the granules in 'Chinese pharmacopoeia' of 2020 edition.
2. The water content of the granule is determined according to 0832 in the three Provisions of 2020 edition "Chinese pharmacopoeia".
3. In the research, a fixed funnel method is adopted to measure the repose angle (alpha), firstly, a funnel is fixedly placed at a position (H) 3cm high of horizontal coordinate paper, and dried particles are carefully poured along the wall of the funnel until the tip of a particle cone formed on the coordinate paper contacts the lower end of the funnel; the diameter of the bottom of the cone (2R) was measured and calculated by substituting the equation of angle of repose (tan α = H/R).
As can be seen from Table 4, the particle size of the heat-clearing and detoxifying traditional Chinese medicine compound granule prepared by the invention meets the requirements of Chinese pharmacopoeia, and has small water content and low hygroscopicity; the angle of repose is less than 30 degrees, and the fluidity is good.
Example 9
Compound granules, 10g per bag, were prepared according to the formulation of examples 1-5 and the preparation method of example 8 and are referred to as granules 1-5, respectively.
104 patients (50 women, 54 men and age 10-65 years old) who have one or more symptoms of fever (axillary temperature is more than or equal to 37.3 ℃), sneeze, watery nasal discharge, cough, pharyngalgia, chilly fever, headache and dizziness, tired pain of the body, normal or red tongue quality, thin and white tongue coating, acute disease onset, quick transmission, epidemic and the like are screened to be homonymy and randomly divided into 6 groups, and the 6 groups have no statistical difference in aspects of vital signs, disease severity, past history, laboratory examination and the like and have comparability;
wherein, 1-5 groups are respectively prepared from 1-5 granules (2 times per day, 1 bag per time);
in group 6, acetaminophen tablets (0.5 g in specification, administration amount: oral administration; 6-12 years old children, 0.5 tablets once; 1 tablet for children over 12 years old and adults, administration can be repeated at intervals of 4-6 hours if fever or pain continues, and no more than 4 times in 24 hours) and cefixime capsules (100 mg in specification, administration amount: oral administration for adults and children over 30 kg in weight: 0.1g once and twice a day, and furthermore, the dosage can be increased or decreased appropriately according to age, weight and symptoms, and 0.2g once and twice a day for severe cases) were used as a control group.
The time to relieve fever and cough was counted for each group and the results are shown in Table 5.
TABLE 5 statistical results
| Grouping | Time to defervesce | Mean time to abate fever | Relieving cough time | Mean time to cough |
| Group | ||||
| 1 particles | 1-3 days | 2.5 days | 3-5 days | 4.5 |
| Group | ||||
| 2 particles | 1-3 |
2 days | 3-6 |
4 |
| Group | ||||
| 3 granules | 1-3 days | 2.5 days | 3-5 |
4 |
| Group | ||||
| 4 particles | 1-3 |
2 days | 3-5 |
4 |
| Group | ||||
| 5 particles | 1-3 |
2 days | 3-5 |
4 days |
| Control group | 1-4 |
3 days | 4-8 |
6 days |
Remarking: the defervescence time means that the axillary temperature is less than or equal to 37.3 ℃, and the non-fever time lasts for more than 24 hours; relieving cough refers to relieving respiratory symptoms such as pharyngalgia and cough.
In the autumn of 2021, some university, lu students and college played balls together, excessive sweating and wet clothes are not changed in time, which causes symptoms of fever, rhinorrhea, headache and poor spirit in both people.
The Lu classmate takes the granules 5 in the morning and evening according to a bag dose, and a large amount of water is drunk in the process, so that the body temperature is normal after 1 day, the symptoms basically disappear after 2 days, and the recovery is basically realized after 3 days.
The fever is developed for 3 days (no medicine is taken in the period, a large amount of water is drunk), the cold symptom is serious, the cough is complicated, the granule 5 is taken according to the dosage of one bag in the morning and evening on the 4 th day, the fever is reduced, the cough symptom is relieved on the day, and the cold symptom basically disappears on the 6 th day.
The Zhang teacher got a cold in noon break, with swollen and sore tonsil, low fever 37.5 degrees, and runny nose. The granule 5 is taken according to a dosage of 2 bags a day, and a large amount of water is drunk in the process, so that the body temperature is normal after 1 day, the tonsil swelling and pain disappear after 2 days, and the patient recovers after 3 days.
The college populus people are infected with cold by others, and have fever for 3 days, flushed face and listlessness, the granules 5 are taken according to the dosage of 2 bags per day, a large amount of water is drunk in the process, the body temperature is normal after 2 days, the mental state is improved, and the patient is healed after 3 days.
Liu teacher, cold with fever, sore throat and cough. The granule 5 is administered at a dosage of 2 bags a day, and a large amount of water is drunk in the process, so that the body temperature is normal after 1 day, and the disease can be cured after 3 days.
The 10-year-old elementary school students with plum classmates have the symptoms of general aching pain, fever and tonsil swelling and pain. The granule 5 is administered at a dose of 2 bags a day, and a large amount of water is drunk in the process, so that the body temperature is normal after 1 day, the whole body ache disappears after 2 days, and the patient is healed in 3 days.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and equivalent substitutions or changes according to the technical solution and the inventive concept of the present invention should be covered by the scope of the present invention.
Claims (10)
1. A traditional Chinese medicine compound for clearing away heat and toxic materials is characterized in that the formula medicinal materials comprise the following components in parts by weight: 15-25 parts of Chinese yam, 7-13 parts of poria cocos, 25-35 parts of honeysuckle, 15-25 parts of houttuynia cordata, 15-25 parts of reed rhizome, 12-18 parts of ageratum, 4-6 parts of medlar and 7-13 parts of liquorice.
2. The compound traditional Chinese medicine for clearing away heat and toxic materials according to claim 1, which is characterized by comprising the following medicinal materials in parts by weight: 20 parts of Chinese yam, 10 parts of poria cocos, 30 parts of honeysuckle, 20 parts of houttuynia cordata, 20 parts of reed rhizome, 15 parts of ageratum, 5 parts of wolfberry and 10 parts of liquorice.
3. The compound traditional Chinese medicine for clearing away heat and toxic materials according to claim 1 or 2, wherein the compound traditional Chinese medicine is in a dosage form of granules, decoction, capsules, tablets or sustained-release preparations.
4. A traditional Chinese medicine compound granule for clearing heat and removing toxicity is characterized by comprising the following raw materials: dextrin and the heat-clearing and detoxifying traditional Chinese medicine compound recipe as claimed in claim 1 or 2.
5. A method for preparing the compound Chinese medicinal granule for clearing away heat and toxic materials as claimed in claim 4, comprising the following steps: decocting rhizoma Dioscoreae, poria, flos Lonicerae, herba Houttuyniae, rhizoma Phragmitis, herba Agastaches, fructus Lycii and Glycyrrhrizae radix with water to obtain water decoction, concentrating the water decoction to obtain extract A, spray drying the extract A and dextrin, and granulating to obtain the Chinese medicinal compound granule with heat and toxic materials clearing away effects.
6. The preparation method of the heat-clearing and detoxifying traditional Chinese medicine compound granule as claimed in claim 5, wherein the density of the extract A is 1.1-1.3g/ml.
7. The preparation method of the compound traditional Chinese medicine granule for clearing away heat and toxic materials according to claim 5 or 6, wherein the weight ratio of the extract A to the dextrin is 4-8.
8. The preparation method of the heat-clearing and detoxifying traditional Chinese medicine compound granule according to any one of claims 6 to 7, wherein the extract A is heated to 65-75 ℃ during spray drying.
9. The preparation method of the compound traditional Chinese medicine granule for clearing away heat and toxic materials according to any one of claims 6 to 8, wherein the air inlet temperature of spray drying is 100 to 110 ℃, and the air outlet temperature is 60 to 70 ℃; preferably, the atomization pressure of the spray drying is 1.5-2.5MPa, and the spray speed is 30-40Hz.
10. The preparation method of the heat-clearing and detoxifying traditional Chinese medicine compound particle according to any one of claims 6 to 9, wherein the water is decocted and extracted for 1 to 3 times, the extraction time is 0.5 to 1.5h each time, and the water consumption for each time is 8 to 12 times of the total weight of Chinese yam, tuckahoe, honeysuckle, heartleaf houttuynia herb, reed rhizome, ageratum, medlar and liquorice; preferably, the decoction is carried out by adding herba Houttuyniae and herba Agastaches after decocting with water, and adding herba Houttuyniae and herba Agastaches 5-15min before decocting and continuing decocting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210590001.0A CN115282235B (en) | 2022-05-27 | 2022-05-27 | Chinese medicinal compound and compound granule for clearing heat and detoxicating, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202210590001.0A CN115282235B (en) | 2022-05-27 | 2022-05-27 | Chinese medicinal compound and compound granule for clearing heat and detoxicating, and preparation method thereof |
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| CN115282235A true CN115282235A (en) | 2022-11-04 |
| CN115282235B CN115282235B (en) | 2023-10-31 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103461607A (en) * | 2013-09-26 | 2013-12-25 | 王文泉 | Honeysuckle compound tea |
| CN107375712A (en) * | 2017-08-25 | 2017-11-24 | 贵州盛茂白芨开发有限公司 | A kind of preparation method of bletilla striata oral liquid |
| CN111228426A (en) * | 2020-04-19 | 2020-06-05 | 湖北清大中药饮片有限公司 | A Chinese medicinal granule used as both medicine and food for treating infantile upper respiratory infection |
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- 2022-05-27 CN CN202210590001.0A patent/CN115282235B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103461607A (en) * | 2013-09-26 | 2013-12-25 | 王文泉 | Honeysuckle compound tea |
| CN107375712A (en) * | 2017-08-25 | 2017-11-24 | 贵州盛茂白芨开发有限公司 | A kind of preparation method of bletilla striata oral liquid |
| CN111228426A (en) * | 2020-04-19 | 2020-06-05 | 湖北清大中药饮片有限公司 | A Chinese medicinal granule used as both medicine and food for treating infantile upper respiratory infection |
Non-Patent Citations (1)
| Title |
|---|
| 张铁兴: "苇茎汤新用" * |
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| CN115282235B (en) | 2023-10-31 |
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