CN115279917A - 多维度解析细胞表观基因组学的方法 - Google Patents
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Abstract
一种多维度解析细胞表观基因组学的方法，该方法包括如下步骤：在细胞中利用ChiTag转座酶和常规Tn5转座酶，分别包埋不同的接头序列，在细胞水平上实现染色质开放区信息和特定蛋白结合序列信息的共同解析。该方法在研究与发育和/或疾病相关的细胞群体异质性和绘制细胞图谱、解析不同临床表征的肿瘤细胞、临床上研究肿瘤细胞演化和/或转移等方面具有重要应用前景。
Description
PCT国内申请，说明书已公开。
Claims (42)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2020/115499 WO2022056704A1 (zh) | 2020-09-16 | 2020-09-16 | 多维度解析细胞表观基因组学的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115279917A true CN115279917A (zh) | 2022-11-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202080098209.XA Pending CN115279917A (zh) | 2020-09-16 | 2020-09-16 | 多维度解析细胞表观基因组学的方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20240018512A1 (zh) |
| EP (1) | EP4215618A1 (zh) |
| CN (1) | CN115279917A (zh) |
| WO (1) | WO2022056704A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116200367B (zh) * | 2023-04-28 | 2023-08-08 | 南京诺唯赞生物科技股份有限公司 | 一种组合物及研究蛋白质-dna互作基因文库的构建方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019184044A1 (zh) * | 2018-03-27 | 2019-10-03 | 上海欣百诺生物科技有限公司 | 一种转座酶-抗体结合蛋白的融合蛋白及其制备与应用 |
| CN111154835A (zh) * | 2020-01-19 | 2020-05-15 | 广州基迪奥生物科技有限公司 | 一种ATAC-seq测序文库的构建方法 |
-
2020
- 2020-09-16 CN CN202080098209.XA patent/CN115279917A/zh active Pending
- 2020-09-16 US US18/026,110 patent/US20240018512A1/en active Pending
- 2020-09-16 EP EP20953564.0A patent/EP4215618A1/en active Pending
- 2020-09-16 WO PCT/CN2020/115499 patent/WO2022056704A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022056704A1 (zh) | 2022-03-24 |
| US20240018512A1 (en) | 2024-01-18 |
| EP4215618A1 (en) | 2023-07-26 |
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