CN115279358A - 用于治疗宫颈细胞异常的包含亚硒酸盐化合物和酸的组合物 - Google Patents

用于治疗宫颈细胞异常的包含亚硒酸盐化合物和酸的组合物 Download PDF

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Publication number
CN115279358A
CN115279358A CN202180017791.7A CN202180017791A CN115279358A CN 115279358 A CN115279358 A CN 115279358A CN 202180017791 A CN202180017791 A CN 202180017791A CN 115279358 A CN115279358 A CN 115279358A
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China
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asc
composition
pharmaceutical composition
lsil
acid
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Pending
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CN202180017791.7A
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English (en)
Chinese (zh)
Inventor
N·富克斯
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Siro Medical Ltd
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Siro Medical Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202180017791.7A 2020-03-03 2021-03-03 用于治疗宫颈细胞异常的包含亚硒酸盐化合物和酸的组合物 Pending CN115279358A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20160817.1 2020-03-03
EP20160817.1A EP3875083A1 (en) 2020-03-03 2020-03-03 Composition for use in a treatment of cervical cell abnormalities comprising selenite compound and acid
PCT/EP2021/055230 WO2021175877A1 (en) 2020-03-03 2021-03-03 Composition for use in a treatment of cervical cell abnormalities comprising selenite compound and acid

Publications (1)

Publication Number Publication Date
CN115279358A true CN115279358A (zh) 2022-11-01

Family

ID=69770560

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180017791.7A Pending CN115279358A (zh) 2020-03-03 2021-03-03 用于治疗宫颈细胞异常的包含亚硒酸盐化合物和酸的组合物

Country Status (23)

Country Link
US (1) US20230092142A1 (https=)
EP (2) EP3875083A1 (https=)
JP (1) JP7840859B2 (https=)
CN (1) CN115279358A (https=)
AR (1) AR122387A1 (https=)
AU (1) AU2021231205B2 (https=)
BR (1) BR112022017436A2 (https=)
CL (1) CL2022002363A1 (https=)
CY (1) CY1126764T1 (https=)
ES (1) ES2976058T3 (https=)
HR (1) HRP20240374T1 (https=)
HU (1) HUE066384T2 (https=)
IL (1) IL296146A (https=)
MA (1) MA58262B1 (https=)
MD (1) MD4084788T2 (https=)
MX (1) MX2022010838A (https=)
PL (1) PL4084788T3 (https=)
RS (1) RS65349B1 (https=)
SM (1) SMT202400126T1 (https=)
TW (1) TW202146004A (https=)
UA (1) UA130108C2 (https=)
WO (1) WO2021175877A1 (https=)
ZA (1) ZA202208848B (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103379899A (zh) * 2011-02-16 2013-10-30 塞罗医疗股份有限公司 用于治疗子宫颈非典型性增生或子宫颈癌的包含亚硒酸盐或含亚硒酸盐化合物的药物制剂
CN112584828A (zh) * 2018-08-28 2021-03-30 赛罗医学有限公司 人乳头瘤病毒高危感染的疗法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2406377C (en) 2000-05-10 2010-07-06 Okopharm Forschungs-Und Entwicklungs-Gmbh Method for reducing the surface area of silicon dioxide
AT412758B (de) 2000-06-05 2005-07-25 Vis Vitalis Lizenz & Handels Verwendung einer selenithältigen lösung zur behandlung viraler erkrankungen
AT412703B (de) 2001-12-04 2005-06-27 Vis Vitalis Lizenz & Handels Verwendung von selenithältigen präparaten zur topischen oder bukkalen anwendung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103379899A (zh) * 2011-02-16 2013-10-30 塞罗医疗股份有限公司 用于治疗子宫颈非典型性增生或子宫颈癌的包含亚硒酸盐或含亚硒酸盐化合物的药物制剂
CN112584828A (zh) * 2018-08-28 2021-03-30 赛罗医学有限公司 人乳头瘤病毒高危感染的疗法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DIETMAR SCHMIDT等: "p16/Ki-67 Dual-Stain Cytology in the Triage of ASCUS and LSIL Papanicolaou Cytology Results From the European Equivocal or Mildly Abnormal Papanicolaou Cytology Study", 《CANCER CYTOPATHOLOGY》, vol. 119, no. 3, XP055715456, DOI: 10.1002/cncy.20140 *

Also Published As

Publication number Publication date
US20230092142A1 (en) 2023-03-23
EP3875083A1 (en) 2021-09-08
RS65349B1 (sr) 2024-04-30
CL2022002363A1 (es) 2023-03-31
JP7840859B2 (ja) 2026-04-06
ES2976058T3 (es) 2024-07-22
EP4084788A1 (en) 2022-11-09
WO2021175877A1 (en) 2021-09-10
CY1126764T1 (el) 2026-02-25
ZA202208848B (en) 2024-09-25
AU2021231205A1 (en) 2022-09-01
BR112022017436A2 (pt) 2022-10-18
EP4084788B1 (en) 2024-02-14
TW202146004A (zh) 2021-12-16
CA3167015A1 (en) 2021-09-10
AU2021231205B2 (en) 2026-02-26
MD4084788T2 (ro) 2024-06-30
IL296146A (en) 2022-11-01
MA58262B1 (fr) 2024-03-29
PL4084788T3 (pl) 2024-06-03
UA130108C2 (uk) 2025-11-12
JP2023516153A (ja) 2023-04-18
AR122387A1 (es) 2022-09-07
HUE066384T2 (hu) 2024-07-28
SMT202400126T1 (it) 2024-05-14
EP4084788C0 (en) 2024-02-14
MX2022010838A (es) 2022-09-27
HRP20240374T1 (hr) 2024-06-07

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