CN115252712A

CN115252712A - Herbaceous plant atomized essential oil with sterilization function and preparation method thereof

Info

Publication number: CN115252712A
Application number: CN202210907159.6A
Authority: CN
Inventors: 杨继广; 杨占文
Original assignee: Atomization Health Industry Group Hainan Co ltd
Current assignee: Atomization Health Industry Group Hainan Co ltd
Priority date: 2022-01-21
Filing date: 2022-07-29
Publication date: 2022-11-01

Abstract

The invention discloses herbal atomized essential oil with a sterilization function and a preparation method thereof, and relates to the technical field of essential oil; to provide a sterilized product without side effects; the essential oil comprises the following components in parts by weight: 10-20 parts of heartleaf houttuynia herb, 3-15 parts of garlic, 3-10 parts of wrinkled gianthyssop herb, 5-20 parts of purslane, 5-15 parts of boat-fruited sterculia seed, 5-20 parts of chrysanthemum, 3-15 parts of honeysuckle, 1-5 parts of orange peel, 2-10 parts of red tangerine peel, 3-8 parts of moringa leaves, 1-5 parts of dried orange peel, 1-5 parts of platycodon grandiflorum, 3-8 parts of dark plum, 3-10 parts of grosvenor momordica fruit and 1-3 parts of clove. The preparation method of the essential oil comprises the following steps: and sequentially weighing the treated concentrated solution A, the concentrated solution B, the garlic juice, the first dry powder, the second dry powder and the third dry powder according to the weight components for later use. The invention can be used for resisting the growth of in vivo bad bacteria, fungi, viruses and parasitic bacteria, has no side effect, and can be used as an auxiliary medicament for long-term use.

Description

Herbaceous plant atomized essential oil with sterilization function and preparation method thereof

Technical Field

The invention relates to the technical field of essential oil, in particular to herbal plant atomized essential oil with a sterilization function and a preparation method thereof.

Background

The clinical application of the existing antibiotics and chemically synthesized antibacterial drugs is limited, and the consequences are more and more serious. Therefore, the trend of seeking high-efficiency and low-toxicity antibacterial substances from natural compounds for inhibiting bacterial and fungal infections has developed. Researches prove that most of the plant essential oil with antibacterial activity is derived from spice and Chinese herbal medicines in food, wherein small molecular phenols, terpenes and aldehydes and ketones are main antibacterial active ingredients of the plant essential oil. It has been reported that plant essential oils possess antibacterial activity properties due to their ability to penetrate the cell membrane of bacteria and enter the interior of cells, exhibiting antibacterial activity in terms of functional properties of the cells and their lipophilic properties. Therefore, plant essential oils are receiving more and more attention as new natural antibacterial and therapeutic drugs.

The antibiotic resistance of bacteria is caused by that the antibiotic has single component, but the single essential oil contains dozens of chemical components and four hundred chemical components, so that the bacteria are difficult to generate the drug resistance. Therefore, we propose an essential oil atomized from herbs with sterilization function.

Disclosure of Invention

The invention aims to solve the defects in the prior art and provides herbal atomized essential oil with a sterilization function and a preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

a herbaceous plant atomized essential oil with a sterilization function comprises the following components in parts by weight: 10-20 parts of heartleaf houttuynia herb, 3-15 parts of garlic, 3-10 parts of wrinkled gianthyssop herb, 5-20 parts of purslane, 5-15 parts of boat-fruited sterculia seed, 5-20 parts of chrysanthemum, 3-15 parts of honeysuckle, 1-5 parts of orange peel, 2-10 parts of red tangerine peel, 3-8 parts of moringa leaves, 1-5 parts of dried orange peel, 1-5 parts of platycodon grandiflorum, 3-8 parts of dark plum, 3-10 parts of grosvenor momordica fruit and 1-3 parts of clove;

the processing steps of the platycodon grandiflorum, the clove, the honeysuckle and the chrysanthemum are as follows: drying the raw materials, crushing, sieving by a 80-mesh sieve, and collecting the first dry powder;

the processing method of the momordica grosvenori comprises the following steps: removing impurities, removing seeds, cutting into small pieces, drying, crushing, sieving with a 80-mesh sieve, and collecting dry powder II;

the processing method of the dried orange peel, the sterculia lychnophora, the red tangerine peel, the agastache rugosus and the orange peel comprises the following steps: removing impurities, cutting into small pieces, drying, crushing, sieving with a 80-mesh sieve, and collecting dry powder III.

Preferably: the processing method of the cordate houttuynia, the purslane and the moringa oleifera leaves comprises the following steps:

a1: putting the raw materials into a pot, adding distilled water 2-5 times of the raw materials, and decocting with medium fire;

a2: decocting until the distilled water amount is reduced by 1/2, and separating the raw materials and the juice;

a3: concentrating the juice under reduced pressure to obtain a concentrated solution A;

the number of times of decoction by medium fire is 3-5.

Preferably: the garlic processing method comprises the following steps:

b1: breaking the wall of the selected undamaged peeled garlic granules to obtain garlic powder;

b2: adding the garlic powder into deionized water, adding alliin, and stirring for 1-2 hours at the temperature of 5-25 ℃ to obtain garlic juice;

the weight ratio of the minced garlic to the deionized water is 1:2; the addition amount of alliin is 1/10 of the weight of Bulbus Allii powder.

Preferably: the processing method of the dark plums comprises the following steps:

c1: putting the raw materials into a pot, adding water with the weight ratio of 10 times of the raw materials, decocting the raw materials with medium and large fire, and collecting decoction;

c2: concentrating the decoction under reduced pressure to obtain concentrated solution B;

the times of decoction with medium and large fire are 2-5, the first time of decoction is 1.5-3 h, and the time of decoction for the rest times of decoction is 0.5-2 h.

A preparation method of herbal atomized essential oil with sterilization function comprises the following steps:

s1: weighing the processed concentrated solution A, the concentrated solution B, the garlic juice, the first dry powder, the second dry powder and the third dry powder in sequence according to the weight components for later use;

s2: firstly, taking out the dry powder I, the dry powder II and the dry powder III, mixing, putting into a supercritical carbon dioxide extractor, and extracting for 0.5-12 h under the conditions of the pressure of 20-50 MPa and the temperature of 40-60 ℃ to obtain semi-finished oil A;

s3: adsorbing the garlic juice by using an adsorbing material, and then distilling and dehydrating the adsorbing material adsorbing the mixed solution to obtain semi-finished oil B;

s4: mixing the concentrated solution A and the concentrated solution B, and adding the mixture into subcritical extraction equipment to extract for 1-3 hours to obtain semi-finished oil C;

s5: mixing the semi-finished oil A, the semi-finished oil B and the semi-finished oil C uniformly, standing for 0.5-1 h, and then performing oil-water separation;

s6: collecting the essential oil separated each time and mixing.

Preferably: the adsorption material is one of porous alumina, activated carbon or diatomite.

Preferably: the working pressure of the distillation is 35-80 Mpa, and the distillation time is 2-12 h;

and the reagent adopted in the dehydration treatment is anhydrous sodium sulfate.

Preferably: the extraction conditions of the subcritical extraction equipment are as follows: the pressure is 3-10 Mpa, and the temperature is 25-40 ℃.

Preferably: the number of the oil-water separation is 3-5.

The invention has the beneficial effects that:

1. the invention adopts a combined method of supercritical extraction, distillation extracting solution and subcritical extraction, thereby effectively reducing energy consumption and cost, reducing pollution and simultaneously greatly improving the yield of essential oil; during the distillation of the extract, the mixed solution is adsorbed by the adsorbing material, so that the evaporation capacity can be further reduced, and the sterilizing essential oil prepared from the herbaceous plants can be used for resisting the growth of in vivo bad bacteria, fungi, viruses and parasitic bacteria, has no side effect, and can be used as an auxiliary medicament for long-term use.

2. According to the invention, the garlic powder is added into deionized water for soaking, and alliin is matched, so that the generation of a large amount of allicin can be effectively improved, and the allicin in the later-stage essential oil is kept as much as possible, thereby inhibiting the propagation of germs; the antibacterial and antibacterial effects can be further improved by adding herba Houttuyniae, herba Agastaches, flos Caryophylli, etc., and mixing with Bulbus Allii.

3. According to the invention, by adding the chrysanthemum, the honeysuckle, the orange peel and the like, especially the chrysanthemum, the effects of diminishing inflammation and the like are improved, meanwhile, the pungent peculiar smell of the garlic is conveniently covered and reduced, so that the essential oil tends to the chrysanthemum taste, and the audience population is enlarged.

4. The invention can be applied to the sterilization, anti-inflammation and atomization treatment of different parts of skin and oral cavity, and can also be used for the sterilization and disinfection of air and instruments.

Drawings

Fig. 1 is a schematic flow chart of a preparation method of an herbal atomized essential oil with a sterilization function provided by the invention.

Detailed Description

The technical solution of the present patent will be further described in detail with reference to the following embodiments.

Reference will now be made in detail to embodiments of the present patent, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present patent and are not to be construed as limiting the present patent.

Example 1:

an atomized essential oil of herbaceous plants with sterilization function is shown in figure 1 and comprises the following components in parts by weight: 15 parts of heartleaf houttuynia herb, 8 parts of garlic, 5 parts of wrinkled gianthyssop herb, 8 parts of purslane, 5 parts of boat-fruited sterculia seed, 10 parts of chrysanthemum, 5 parts of honeysuckle, 2 parts of orange peel, 2 parts of tangerine peel, 3 parts of moringa leaves, 1.5 parts of tangerine peel, 1.5 parts of platycodon grandiflorum, 3 parts of dark plum fruit, 3 parts of grosvenor momordica fruit and 2 parts of clove.

The treatment method of the houttuynia cordata, the purslane and the moringa oleifera leaves comprises the following steps:

a3: concentrating the juice under reduced pressure to obtain concentrated solution A.

Preferably, the number of times of decoction by medium fire is 3-5.

The garlic processing method comprises the following steps:

b2: adding the garlic powder into deionized water, adding alliin, and stirring for 1-2 h at 5-25 ℃ to obtain garlic juice, thereby effectively improving the large-scale generation of allicin.

Preferably, the weight ratio of the minced garlic to the deionized water is 1:2; the addition amount of alliin is 1/10 of the weight of Bulbus Allii powder.

The processing steps of the platycodon grandiflorum, the clove, the honeysuckle and the chrysanthemum are as follows: drying the raw materials, crushing, sieving with a 80-mesh sieve, and collecting the first dry powder.

The processing method of the momordica grosvenori comprises the following steps: removing impurities, removing seeds, cutting into small pieces, drying, crushing, sieving with a 80-mesh sieve, and collecting dry powder II.

The processing method of the dark plum comprises the following steps:

c2: concentrating the decoction under reduced pressure to obtain concentrated solution B.

Preferably, the times of decoction by medium and large fire are 2-5, the first time of decoction is 1.5-3 h, the time of decoction of the rest times of decoction is 0.5-2 h, and decoction liquid of each time is collected and combined to obtain a decoction liquid body.

When the garlic powder is used, the garlic powder is added into deionized water for soaking, alliin is matched, so that the generation of a large amount of allicin can be effectively improved, the allicin in the later-stage essential oil is kept as much as possible, and the propagation of germs is inhibited; the antibacterial and antibacterial effects can be further improved by adding herba Houttuyniae, herba Agastaches, flos Caryophylli, etc., and mixing with Bulbus Allii. By adding chrysanthemum, honeysuckle, orange peel and the like, particularly chrysanthemum, the effects of diminishing inflammation and the like are improved, and simultaneously the pungent peculiar smell of garlic is conveniently covered and reduced, so that the essential oil tends to the taste of chrysanthemum, and audience groups are enlarged.

Selecting 20 grade I, II and III patients of 18-50 years old helicobacter pylori, performing atomized essential oil fumigation treatment for 20-40min each day, and testing tool C13;

reference level: stage 0: < 4DOB; stage I: 4-20DOB; II stage: 20-40DOB; grade III: is more than 40DOB;

the test results were as follows:

from the above, the bigger the DOB value of helicobacter pylori is, the longer the nebulization treatment time is and the effect is slow, especially the curative effect on the grade I patients is faster.

Example 2:

a herbal atomized essential oil with sterilization function is shown in figure 1 and comprises the following components in parts by weight: 15 parts of heartleaf houttuynia herb, 10 parts of garlic, 5 parts of wrinkled gianthyssop herb, 12 parts of purslane, 8 parts of boat-fruited sterculia seed, 12 parts of chrysanthemum, 8 parts of honeysuckle, 1.5 parts of orange peel, 1.5 parts of red tangerine peel, 3.5 parts of moringa leaves, 2 parts of tangerine peel, 1 part of platycodon root, 3.5 parts of dark plum fruit, 4 parts of grosvenor momordica fruit and 2 parts of clove.

In this example, 20 subjects of H.pylori grade I, II and III, 18-50 years old, were each selected and treated with atomized essential oil fumigation for 20-40min per day, test tool C13;

reference level: level 0: < 4DOB; stage I: 4-20DOB; II level: 20-40DOB; grade III: is more than 40DOB;

the test results were as follows:

class I	Reduction of%	Class II	Reduce%	Class III	Reduction of%
						7d	45	7d	25	7d	15
15d	70	15d	55	15d	35
						30d	95	30d	75	30d	55

As can be seen from the above, the greater the DOB value of helicobacter pylori, the longer the atomization treatment time and the slower the effect, especially the faster the curative effect on the grade I patients.

Example 3:

a herbal atomized essential oil with sterilization function is shown in figure 1 and comprises the following components in parts by weight: 18 parts of heartleaf houttuynia herb, 6 parts of garlic, 5 parts of wrinkled gianthyssop herb, 15 parts of purslane, 8 parts of boat-fruited sterculia seed, 9 parts of chrysanthemum, 8 parts of honeysuckle, 1 part of orange peel, 2.5 parts of tangerine peel, 3.5 parts of moringa leaves, 1 part of tangerine peel, 2.5 parts of platycodon grandiflorum, 4 parts of dark plum fruit, 5 parts of grosvenor momordica fruit and 1.5 parts of clove.

reference level: level 0: < 4DOB; stage I: 4-20DOB; II stage: 20-40DOB; grade III: is more than 40DOB;

the test results were as follows:

class I	Reduction of%	Class II	Reduction of%	Class III	Reduction of%
						7d	20	7d	10	7d	10
15d	50	15d	35	15d	20
						30d	85	30d	55	30d	35

Example 4:

a method for preparing herbal atomized essential oil of examples 1 to 3 with sterilization function, as shown in fig. 1, comprising the following steps:

s4: mixing the concentrated solution A and the concentrated solution B, and adding the mixture into subcritical extraction equipment for extraction for 1-3 hours to obtain semi-finished oil C;

s6: collecting the essential oil separated each time and mixing.

The adsorption material is one of porous alumina, activated carbon or diatomite.

The working pressure of the distillation is 35-80 Mpa, and the distillation time is 2-12 h.

The extraction conditions of the subcritical extraction equipment are as follows: the pressure is 3-10 Mpa, the temperature is 25-40 ℃, and the extractant is ether.

The number of times of oil-water separation is 3-5.

When the method is used, a combined method of supercritical extraction, distillation extracting solution and subcritical extraction is adopted, so that the energy consumption and the cost are effectively reduced, the pollution is reduced, and the yield of the essential oil is greatly improved; during the distillation of the extract, the mixed liquid is adsorbed by the adsorbing material, so that the evaporation capacity can be further reduced.

The patent can be applied to sterilization, inflammation diminishing and atomization treatment of skins and oral cavities at different parts, and can also be used for sterilization and disinfection of air and instruments.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims

1. The herbal plant atomized essential oil with the sterilization function is characterized by comprising the following components in parts by weight: 10 to 20 parts of heartleaf houttuynia herb, 3 to 15 parts of garlic, 3 to 10 parts of wrinkled gianthyssop herb, 5 to 20 parts of purslane, 5 to 15 parts of boat-fruited sterculia seed, 5 to 20 parts of chrysanthemum, 3 to 15 parts of honeysuckle, 1 to 5 parts of orange peel, 2 to 10 parts of red tangerine peel, 3 to 8 parts of moringa leaves, 1 to 5 parts of tangerine peel, 1 to 5 parts of platycodon root, 3 to 8 parts of dark plum, 3 to 10 parts of grosvenor momordica fruit and 1 to 3 parts of clove;

2. The atomized essential oil of herbaceous plants with the sterilization function as claimed in claim 1, wherein the processing method of the houttuynia cordata, the purslane and the moringa oleifera leaves comprises the following steps:

the number of times of decoction by medium fire is 3-5.

3. The essential oil atomized by herbaceous plants with sterilization function as claimed in claim 2, wherein the processing method of garlic comprises the following steps:

4. The essential oil of claim 3, wherein the smoked plum is prepared by the following steps:

5. The preparation method of the herbal atomized essential oil with the sterilization function is characterized by comprising the following steps:

s2: firstly, taking out the dry powder I, the dry powder II and the dry powder III, mixing, putting into a supercritical carbon dioxide extractor, and extracting for 0.5-12 h under the conditions of pressure of 20-50 MPa and temperature of 40-60 ℃ to obtain semi-finished oil A;

s5: uniformly mixing the semi-finished oil A, the semi-finished oil B and the semi-finished oil C, standing for 0.5-1 h, and then performing oil-water separation;

s6: collecting the essential oil separated each time and mixing.

6. The method for preparing herbal atomized essential oil with sterilization function as claimed in claim 5, wherein the adsorption material is one of porous alumina, activated carbon or diatomite.

7. The preparation method of the atomized essential oil of herbaceous plants with sterilization function as claimed in claim 6, wherein the distillation working pressure is 35-80 Mpa, and the distillation time is 2-12 h;

8. The method for preparing atomized essential oil of herbaceous plants with sterilization function as claimed in claim 7, wherein the extraction conditions of the subcritical extraction equipment are: the pressure is 3-10 Mpa, and the temperature is 25-40 ℃.

9. The method for preparing herbal atomized essential oil with sterilization function as claimed in claim 5, wherein the number of times of oil-water separation is 3-5.