CN115245847A - Micro-mixing chip based on Tesla valve - Google Patents

Micro-mixing chip based on Tesla valve Download PDF

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Publication number
CN115245847A
CN115245847A CN202210951293.6A CN202210951293A CN115245847A CN 115245847 A CN115245847 A CN 115245847A CN 202210951293 A CN202210951293 A CN 202210951293A CN 115245847 A CN115245847 A CN 115245847A
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China
Prior art keywords
layer
mixing
tesla valve
tesla
connecting port
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CN202210951293.6A
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CN115245847B (en
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郭克凡
项楠
赵天宇
程伟旗
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Southeast University
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Southeast University
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3039—Micromixers with mixing achieved by diffusion between layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)

Abstract

The invention discloses a micro-mixing chip based on a Tesla valve, which relates to the technical field of micro-flow control, wherein two solutions to be mixed are introduced into two inlets of an inlet layer, enter a first Tesla valve structure of an upper mixing layer, and enter a first Tesla valve structure of a lower mixing layer through a connecting layer; then flows into the second tesla valve structure of the upper mixing layer again through the connecting layer for mixing, the mixed solution flows out, and then enters the second tesla valve structure of the lower mixing layer again through the connecting layer, and finally the completely mixed solution flows out from the outlet layer and is collected. This application make full use of can pile up the little mixed chip of thin film material preparation, the mixed structure who uses the Tesla valve has strengthened the mixed effect to different solutions, has realized quick automatic high-efficient mixing to different viscoelastic solutions.

Description

Micro-mixing chip based on Tesla valve
Technical Field
The invention relates to the technical field of microfluidics, in particular to a micro-mixing chip based on a Tesla valve.
Background
The microfluidic technology has the advantages of small sample consumption, low equipment cost, strong controllability and the like. Therefore, it has a great influence on the fields of drug development and biomedical diagnosis, and has been widely used in the bioanalysis and chemical industries. Rapid micro-mixing is an important technology of microfluidic technology, plays a key role in a miniaturized total analysis system (μ TAS) or a lab-on-a-chip (LOC) device, and can be used for realizing the synthesis of nanomaterials and the rapid mixing of cells, reagents and organic solutions in bioengineering and biochemical systems. However, laminar flow at relatively low Reynolds numbers (Re < 1) in the micro-scale tends to result in low momentum convection phenomena. In this case, mixing occurs mainly by slow molecular diffusion, requiring long channels and prolonged retention times to ensure adequate reaction. Therefore, it is very important to design a micromixer for increasing the contact area and the contact time of the sample to enhance the micromixer in the laminar flow state.
Disclosure of Invention
The invention aims to provide a micro-mixing chip based on a Tesla valve, aiming at the problems in the background art.
According to the technical scheme, the micro-mixing chip based on the Tesla valve comprises an inlet layer, an upper mixing layer, three connecting layers, a lower mixing layer and an outlet layer which are sequentially arranged from top to bottom;
a plurality of mixed liquid inlets are formed in the inlet layer;
the upper mixing layer is provided with an upper mixing layer inlet, a Tesla valve mixing structure, a first connecting port a, a second connecting port a and a third connecting port a;
each layer of the connecting layers is provided with a first connecting port b, a second connecting port b and a third connecting port b;
the lower mixing layer is provided with a Tesla valve mixing structure, a first connecting port c, a second connecting port c, a third connecting port c, a mixed liquid outflow channel and a lower mixing layer outlet;
a mixed liquid outlet is arranged on the outlet layer;
the Tesla valve mixing structure arranged on the upper mixing layer comprises Tesla valves a and b; the Tesla valve mixing structure arranged on the lower mixing layer comprises Tesla valves c and d;
the inlets of the upper mixing layer are provided with a plurality of inlets which are respectively communicated with the mixed liquid inlets on the inlet layer; the input end of the Tesla valve a is respectively communicated with the inlets of the upper mixing layers, and the output end of the Tesla valve a is communicated with the first connecting port a; the input end of the Tesla valve b is communicated with the second connecting port a, and the output end of the Tesla valve b is communicated with the third connecting port a;
the input end of the Tesla valve c is communicated with the first connecting port c, the output end of the Tesla valve c is communicated with the second connecting port c, and the second connecting port c is communicated with the second connecting port a through the second connecting port b; the first connecting port c is communicated with the first connecting port a through a first connecting port b; the input end of the Tesla valve d is connected with the third connecting port c, and the output end of the Tesla valve d is connected with the mixed liquid outflow channel and the outlet of the lower mixed layer; the third connection port c communicates with the third connection port a via the third connection port b; the outlet of the lower mixing layer is communicated with the outlet of the mixed liquid;
the mixed liquid passes through the mixed liquid inlet and is mixed by Tesla valves a, c, b and d in sequence and is discharged out of the chip through the outlet of the lower mixed layer and the outlet of the mixed liquid.
Preferably, the tesla valve mixing structures are communicated by two annular flow passages with the centers of arc-edge trapezoids, and the bottom angles of the arc-edge trapezoids are 30 degrees; the mixing structures of the four tesla valves in the upper mixing layer and the lower mixing layer have the same shape and are distributed in a ring shape overall.
Preferably, the different sizes of the connecting openings in the upper mixed layer, the connecting layer and the lower mixed layer are the same.
Preferably, the inlet layer, the upper mixed layer, the lower mixed layer and the outlet layer are all thin film materials.
Preferably, the upper layer and the lower layer which are in the same shape in the three layers in the connecting layer are made of thin film materials and are respectively connected with the upper mixing layer and the lower mixing layer, and the middle layer is made of double-sided adhesive materials and is connected with the upper layer and the lower layer.
Preferably, the width of the output end of the Tesla valve d is the same as that of the flow channel of the mixed liquid outflow channel; the width of the flow channel of the mixed liquid outflow channel is smaller than the diameter of the outlet of the lower mixed layer.
Preferably, the inlet layer, the upper mixing layer, the connecting layer, the lower mixing layer and the outlet layer are provided with coaxial positioning holes at four corners and are connected in a bonding manner through positioning keys from top to bottom.
Preferably, the inlet layer, the upper mixing layer, the upper and lower layers of the collecting layer, the lower mixing layer and the outlet layer are all formed by laser cutting.
Compared with the prior art, the invention has the following beneficial technical effects:
1. the Tesla valve is designed into an annular flow channel with the center being in the shape of an arc edge trapezoid, so that the length of the flow channel and the mixing time of a solution can be effectively increased. And in the mixing process, under the combined action of wall friction and fluid viscoelasticity, a coanda effect occurs in the mixing flow channel, so that the solution is forced to flow tightly close to the channel wall of the island. In addition, the solution in the bent passage of the tesla valve will flow back at an angle to the straight passage, where it will collide with the flowing solution in the straight passage for mixing. And the flow resistance of each channel in the Tesla valve is different, the momentum difference of the collision solution is increased, and the mixing efficiency is improved.
2. In the invention, for three connecting layers with the same shape, the mixed structures of different layers can be connected in a mode of overlapping connecting ports; and when the solution enters the superposed connecting ports, because the width of the channel is suddenly enlarged, transverse secondary flow is generated in the flow channel to form a multi-vortex phenomenon, and the strong interference of the stacked connecting layers to the mixing process can further enhance the mixing of the two solutions.
3. In addition, due to the staggered design of the mixing structure of the Tesla valve, the solution can be continuously and powerfully mixed in different layers.
4. The application make full use of stackable film material preparation mixes the chip a little, uses the mixed structure of tesla valve to strengthen the mixed effect to different solutions, has realized quick automatic high-efficient mixing to different viscoelastic solutions.
Drawings
FIG. 1 is an exploded view of a Tesla valve based micro-hybrid chip according to the present invention;
FIG. 2 is a schematic view of an inlet layer in the present invention;
FIG. 3 is a schematic view of an upper hybrid layer in the present invention;
FIG. 4 is a schematic view of a connecting layer in the present invention;
FIG. 5 is a schematic view of a lower hybrid layer in the present invention;
FIG. 6 is a schematic view of an exit layer in the present invention;
FIG. 7 is a schematic view of a Tesla valve stack according to the present invention;
FIG. 8 is a schematic diagram of a Tesla valve micro-hybrid chip in accordance with the present invention;
FIG. 9 is a graph of the results of various micro-mixing experiments in the examples of the present application.
Reference numerals are as follows: 1. an inlet layer; 2. an upper mixed layer; 3. a connecting layer; 4. a lower mixed layer; 5. an exit layer; 11. a mixed liquid inlet; 21. an upper mixing layer inlet; 22. a tesla valve mixing structure; 23. a first connection port a; 24. a second connection port a; 25. a third connection port a; 31. a first connection port b; 32. a second connection port b; 33. a third connection port b; 41. a first connection port c; 42. a second connection port c; 43. a third connection port c; 44. a mixed liquid outflow channel; 45. an outlet of the lower mixing layer; 51. a mixed liquid outlet; 221. and an annular flow passage.
Detailed Description
As shown in fig. 1, the present application includes seven layers of bonding connection from top to bottom, which include in sequence from top to bottom: the inlet layer 1, go up mix layer 2, three-layer articulamentum 3, mix layer 4 and export layer 5 down, the four corners position on every layer all corresponds and is provided with the location mounting hole, and every layer links to each other in proper order. The upper and lower two layers of the inlet layer 1, the upper mixing layer 2 and the connecting layer 3, the lower mixing layer 4 and the outlet layer 5 are made of PET silica gel, and the middle layer of the connecting layer 3 is made of double-faced adhesive tape. Seven layers of chips are stacked through bonding to form a Tesla valve micro-mixing flow channel in the space.
As shown in fig. 2, two different viscoelastic solutions to be mixed are injected into the chip from different mixed solution inlets 11 by syringe pumps at a constant flow rate, and enter the upper mixed layer 2 by overlapping and connecting the corresponding mixed solution inlets 11 with the upper mixed layer inlets 21.
As shown in fig. 3, the mixture solution to be mixed is introduced into a tesla valve mixing structure 22 of the upper mixed layer 2 from an upper mixed layer inlet 21; the Tesla valve is designed into an annular flow channel 221 with a trapezoidal center with arc edges, so that the length of the flow channel and the mixing time of the solution can be effectively increased. In the mixing process, under the combined action of wall friction and fluid viscoelasticity, a coanda effect occurs in the mixing flow channel, and the solution is forced to flow tightly against the channel walls of the islands. In addition, the solution in the bent passage of the tesla valve will flow back at an angle to the straight passage, where it will collide with the flowing solution in the straight passage for mixing. And the flow resistance of each channel in the Tesla valve is different, the momentum difference of the collision solution is increased, and the mixing efficiency is improved.
As shown in fig. 4, for three connecting layers 3 with the same shape, the mixed structure of different layers can be connected by overlapping the connecting ports; and when the solution enters the superposed connecting ports, because the channel width is suddenly enlarged, transverse secondary flow is generated in the flow channel to form a multi-vortex phenomenon, and the strong interference of the stacked connecting layers 3 to the mixing process can further enhance the mixing of the two solutions.
As shown in fig. 5, the solution is introduced into the lower mixing layer 4 through different connection ports, and furthermore, due to the staggered design of the tesla valve mixing structure 22, a continuous and powerful mixing of the solution can be achieved at different layers.
As shown in fig. 6, the mixed solution outlet 51 of the outlet layer 5 is coaxially communicated with the lower mixed layer outlet 45, and the mixed solution can be quickly collected into a desired container.
The stack of the Tesla valve mixing structure 22 and the connection port mainly used in the chip is shown in FIG. 7; a top view of the monolithic micromixer stack is shown in fig. 8.
When in manufacturing, the required structure is carved on the double-sided adhesive material with the PVC substrate covered on the selected surface by a laser. And during bonding connection, changing the microstructures of different layers by using a plasma cleaning machine to perform surface treatment, and inserting positioning pins into the positioning holes of different layers by using a positioning clamp to perform fixing and bonding respectively.
The micro-mixing chip is manufactured by fully utilizing the stackable film materials, the mixing effect of different solutions is enhanced by using the mixing structure of the Tesla valve, the adopted film materials can bear high flux of more than 20ml/min, a wide flow speed operation range is provided for subsequent experiments, the process avoids a complex manufacturing process, and subsequent rapid batch production of the micro-mixer is allowed. As shown in fig. 9, the chip was measured for mixing efficiency at different flow rates and for mixing efficiency of different viscoelastic solutions. As a result, the mixing efficiency of over 86.96 percent can be achieved when the flow rate is more than 500 mu L/min, and the mixing efficiency is over 89.98 percent when the viscoelastic solution with the PEO concentration of 0-500ppm is used, so that the mixing chip can realize rapid, automatic and high-efficiency mixing for different viscoelastic solutions.
The embodiments of the present invention have been described in detail with reference to the drawings, but the present invention is not limited thereto, and various changes can be made within the knowledge of those skilled in the art without departing from the gist of the present invention.

Claims (9)

1. A micro-mixing chip based on a Tesla valve is characterized by comprising an inlet layer (1), an upper mixing layer (2), three connecting layers (3), a lower mixing layer (4) and an outlet layer (5) which are sequentially arranged from top to bottom;
the inlet layer (1) is provided with a plurality of mixed liquid inlets (11);
the upper mixing layer (2) is provided with an upper mixing layer inlet (21), a Tesla valve mixing structure (22), a first connecting port a (23), a second connecting port a (24) and a third connecting port a (25);
each layer of the connecting layer (3) is provided with a first connecting port b (31), a second connecting port b (32) and a third connecting port b (33);
the lower mixing layer (4) is provided with a Tesla valve mixing structure (22), a first connecting port c (41), a second connecting port c (42), a third connecting port c (43), a mixed liquid outflow channel (44) and a lower mixing layer outlet (45);
a mixed liquid outlet (51) is arranged on the outlet layer (5);
a Tesla valve mixing structure (22) provided on the upper mixing layer (2) comprising Tesla valves a, b; a Tesla valve mixing structure (22) provided on the lower mixing layer (4) including Tesla valves c, d;
the upper mixing layer inlets (21) are provided with a plurality of inlets which are respectively communicated with the mixed liquid inlets (11) on the inlet layer (1); the input end of the Tesla valve a is respectively communicated with the upper mixing layer inlet (21), and the output end of the Tesla valve a is communicated with a first connecting port a (23); the input end of the Tesla valve b is communicated with the second connecting port a (24), and the output end of the Tesla valve b is communicated with the third connecting port a (25);
the input end of the Tesla valve c is communicated with the first connecting port c (41), the output end is communicated with the second connecting port c (42), and the second connecting port c (42) is communicated with the second connecting port a (24) through the second connecting port b (32); the first connection port c (41) is communicated with the first connection port a (23) through the first connection port b (31); the input end of the Tesla valve d is connected with a third connecting port c (43), and the output end of the Tesla valve d is connected with a mixed liquid outflow channel (44) and a lower mixed layer outlet (45); the third connection port c (43) communicates with the third connection port a (25) via the third connection port b (33); the lower mixing layer outlet (45) is communicated with the mixed liquid outlet (51);
the mixed liquid passes through a Tesla valve a, a Tesla valve c, a mixed liquid inlet (11) and is mixed in sequence and discharged out of the chip through a lower mixed layer outlet (45) and a mixed liquid outlet (51).
2. A tesla valve based micro hybrid chip according to claim 1, wherein the tesla valve mixing structure (22) is connected by two annular flow channels (221) with centre in the shape of a trapezium with a radius of 30 ° at the base; the four Tesla valve mixing structures (22) in the upper mixing layer (2) and the lower mixing layer (4) are consistent in shape and are distributed in an annular shape overall.
3. A tesla-valve based micro-hybrid chip according to claim 1, characterised in that the different connection port sizes in the upper hybrid layer (2), the connection layer (3) and the lower hybrid layer (4) are all the same.
4. A tesla valve based micro-mixing chip according to claim 1, characterized in that the inlet layer (1), the upper mixed layer (2), the lower mixed layer (4) and the outlet layer (5) are all thin film materials.
5. A micro-hybrid chip based on tesla valves according to claim 1, characterized in that the upper and lower layers of the connecting layer (3) with the same shape are made of thin film material and connected to the upper hybrid layer (2) and the lower hybrid layer (4), respectively, and the middle layer is made of double-sided adhesive material connecting the upper and lower layers.
6. A tesla valve based micro mixing chip as claimed in claim 1, wherein the output end of tesla valve d is the same width as the flow channel of the mixed liquid outflow channel (44); the flow channel width of the mixed liquid outflow channel (44) is smaller than the diameter of the lower mixed layer outlet (45).
7. A micro-hybrid chip based on tesla valves according to claim 1, characterized in that the inlet layer (1), the upper hybrid layer (2), the connection layer (3), the lower hybrid layer (4) and the outlet layer (5) are provided with coaxial positioning holes at four corners and are bonded and connected by positioning keys from top to bottom.
8. A tesla valve based micro-hybrid chip according to claim 1, wherein the connection ports stacked at different layers connect a plurality of tesla valves to form spatially connected chambers; and generates a transverse secondary flow.
9. A tesla valve based micro-hybrid chip according to claim 1, characterised in that the upper and lower layers of the inlet layer (1), the upper hybrid layer (2), the collection layer (3), the lower hybrid layer (4) and the outlet layer (5) are cut and shaped by laser machining.
CN202210951293.6A 2022-08-09 2022-08-09 Micro-hybrid chip based on Tesla valve Active CN115245847B (en)

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Cited By (1)

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CN117323879A (en) * 2023-11-30 2024-01-02 中国科学院精密测量科学与技术创新研究院 Multistage split micromixer and application thereof

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CN215463918U (en) * 2021-04-02 2022-01-11 胡佳志 Micro mixer based on Tesla valve structure
CN114367321A (en) * 2022-01-06 2022-04-19 上海交通大学 Reusable multi-index microfluidic detection system based on coding microspheres and use method
CN114608364A (en) * 2022-01-22 2022-06-10 合肥工业大学 Micro multi-channel fluid phase-change type uniform-temperature heat exchange plate

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US20160279634A1 (en) * 2013-09-30 2016-09-29 Göran Stemme A microfluidic device, use and methods
CN110787844A (en) * 2019-09-26 2020-02-14 南方科技大学 Microfluidic chip and preparation method and application thereof
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CN112827407A (en) * 2021-03-05 2021-05-25 锦州镁赫化学科技有限公司 Continuous flow micro mixer
CN215463918U (en) * 2021-04-02 2022-01-11 胡佳志 Micro mixer based on Tesla valve structure
CN114367321A (en) * 2022-01-06 2022-04-19 上海交通大学 Reusable multi-index microfluidic detection system based on coding microspheres and use method
CN114608364A (en) * 2022-01-22 2022-06-10 合肥工业大学 Micro multi-channel fluid phase-change type uniform-temperature heat exchange plate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117323879A (en) * 2023-11-30 2024-01-02 中国科学院精密测量科学与技术创新研究院 Multistage split micromixer and application thereof
CN117323879B (en) * 2023-11-30 2024-02-27 中国科学院精密测量科学与技术创新研究院 Multistage split micromixer and application thereof

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