CN115245625A - Magnetic nanoparticle targeted delivery displacement regulation and control device - Google Patents
Magnetic nanoparticle targeted delivery displacement regulation and control device Download PDFInfo
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- CN115245625A CN115245625A CN202110240189.1A CN202110240189A CN115245625A CN 115245625 A CN115245625 A CN 115245625A CN 202110240189 A CN202110240189 A CN 202110240189A CN 115245625 A CN115245625 A CN 115245625A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
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Abstract
The invention relates to the technical field of medical instruments, in particular to a regulating and controlling device for magnetic nanoparticles. A magnetic nanoparticle targeted delivery displacement regulation and control device comprises a C-shaped support, a rotary magnet device arranged on the C-shaped support and a moving platform used for controlling the C-shaped support to perform space motion. The moving platform is provided with a C-shaped support sleeve, the C-shaped support penetrates through the C-shaped support sleeve, a motor gear transmission device is arranged in the C-shaped support sleeve, and correspondingly, an arc-shaped rack matched with a transmission gear of the motor gear transmission device is arranged on the outer side of the C-shaped support. The C-shaped bracket can rotate around the central axis thereof under the driving of the motor gear transmission device. And rotary magnet devices are respectively arranged at two ends of the C-shaped bracket. The invention provides a motion path regulating device of magnetic nanoparticles, which is used for accurately conveying magnetic nanoparticles loaded with drugs to a specified treatment position under the action of a magnetic field so as to realize targeted delivery of the drugs.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a regulating and controlling device for magnetic nanoparticles.
Background
The magnetic nanoparticles have different physical and chemical properties such as biocompatibility, superparamagnetism and the like, are magnetic materials with wider application range at present, and can be applied to the biomedical fields of disease treatment and diagnosis, drug loading, magnetic Resonance Imaging (MRI) and the like. The magnetic nano-particles are nano-scale particles and generally comprise a magnetic core consisting of metal oxides such as iron, cobalt, nickel and the like and a high polymer/silicon/hydroxyapatite shell layer wrapping the magnetic core. The common nuclear layer is made of Fe3O4 or gamma-Fe 2O3 with super-paramagnetic or ferromagnetic properties, has magnetic guidance (targeting), can realize directional movement under the action of an external magnetic field, and is convenient to position and separate from a medium. The most common shell layer is composed of high molecular polymers, and active groups coupled on the shell layer can be combined with various biomolecules, such as proteins, enzymes, antigens, antibodies, nucleic acids and the like, so as to realize the functionalization of the shell layer. Therefore, the magnetic nanoparticles have the characteristics of magnetic particles and polymer particles, and have magnetic guidance, biocompatibility, small-size effect, surface effect, active groups and certain biomedical functions. However, in the prior art, the magnetic field used in the magnetic field flow separation method for regulating the displacement path of the magnetic nanoparticles is mainly a static magnetic field and a rotating magnetic field. If the external magnetic field is a static magnetic field, the action range is limited, the migration action range of the magnetic field on the particles is limited, and the movement range and the adjustable precision of the magnetic nanoparticles are limited. Compared with a static magnetic field, the rotating magnetic field improves the separation effect of the magnetic particles and has certain advantages. In the existing rotating magnetic field, a permanent magnet is fixed on a rotating shaft connected with a motor, the magnet is driven by the motor to do periodic circular motion right above or right below a conveying channel of magnetic nanoparticles, and the rotating direction of the magnet is the same as the current-carrying direction. The rotating magnetic field changes the acting frequency of the magnetic field on the magnetic particles by adjusting the rotating speed of the motor, and the precision is not high. Changing the magnetic induction intensity in the conveying channel needs to adjust the distance between the magnet and the separation channel, and the realization is difficult to ensure the parallelism of the rotary motion track of the magnet and the conveying channel. It is difficult to deliver the magnetic nanoparticles to a designated location.
Disclosure of Invention
The invention provides a motion path regulating and controlling device of magnetic nanoparticles, which is used for accurately conveying the magnetic nanoparticles carrying drugs to a specified treatment position through the action of a magnetic field and realizing targeted delivery of the drugs, and aims to solve the problems that the regulation and control precision of a rotating magnetic field on the magnetic nanoparticles is not high, the displacement regulation of a rotating magnet is difficult to accurately realize and the like in the prior art so that the magnetic nanoparticles are difficult to convey to the specified treatment position.
In order to achieve the above purpose, the present invention adopts the following technical scheme that a magnetic nanoparticle targeted delivery displacement regulation and control device comprises a C-shaped support, a rotary magnet device arranged on the C-shaped support, and a moving platform for controlling the C-shaped support to perform spatial motion.
Furthermore, a C-shaped support frame sleeve is arranged on the moving platform, the C-shaped support frame penetrates through the C-shaped support frame sleeve, a motor gear transmission device is arranged in the C-shaped support frame sleeve, and correspondingly, an arc-shaped rack matched with a transmission gear of the motor gear transmission device is arranged on the outer side of the C-shaped support frame. The C-shaped bracket can rotate around the central axis thereof under the driving of the motor gear transmission device.
Furthermore, rotating magnet devices are respectively installed at two ends of the C-shaped support and comprise a rotating motor and a permanent magnet arranged on a shaft of the rotating motor.
Furthermore, the mobile platform is a three-axis mobile platform, and the movement of the C-shaped support in three-dimensional space of an X axis, a Y axis and a Z axis can be realized.
Further preferably, the moving platform is controlled by a stepping motor, the lowest moving stepping speed of 0.05mm/s can be achieved, and the movement in the up-down direction, the front-back direction and the left-right direction can be realized. Similarly, the motor gear transmission device for controlling the C-shaped bracket to rotate around the central axis of the C-shaped bracket also adopts the stepping motor to control the rotation, so that the C-shaped bracket can rotate in the C-shaped bracket sleeve, the single side of the rotation angle is less than 50 degrees, and the total rotation angle is less than 100 degrees. The C-shaped support can move to stay at any position in the range, the control precision can reach 1 degree, and the control precision is extremely high.
Further, the number of the permanent magnets is even. An even number of permanent magnets are evenly spaced about the motor shaft with the NS-stages of two oppositely disposed permanent magnets facing in opposite directions.
Further, the number of the permanent magnets is 4.
Furthermore, the permanent magnet is arranged in a magnet fixing sleeve, and the magnet fixing sleeve is connected with a motor shaft.
Furthermore, the permanent magnet is a cylindrical magnet, and an included angle is formed between the central axis of the cylindrical magnet and the shaft of the motor. The inclined arrangement of the cylindrical magnets relative to the motor shaft is beneficial to the mutual overlapping of the magnetic fields of the cylindrical magnets, and an overlapping point with the strongest magnetic field intensity is formed in space.
Furthermore, an included angle between the central axis of the cylindrical magnet and the shaft of the motor is 30 degrees.
In the technical scheme provided by the invention, the C-shaped bracket can be replaced by a U-shaped bracket, and the rotary magnet devices are arranged at two ends of the U-shaped bracket.
The technical scheme adopted by the invention has the following beneficial effects:
1. the combination of the support and the moving platform is adopted to control the position of the rotating magnet device in space, so that the rotating magnetic field generated by the rotating magnet can move, and further, the overlapping of the rotating magnetic fields generated by the plurality of rotating magnets in space necessarily has a point with the maximum magnetic field intensity, so that the aggregation of the magnetic nanoparticles at the point can be realized by controlling the specific position of the point, and the magnetic nanoparticles can reach any specified position.
2. According to the technical scheme, the two groups of rotary magnets are arranged in the height direction, so that the magnetic field intensity in an action area can be effectively enhanced, and the accurate displacement control of the magnetic nanoparticles in the height direction can be realized.
According to the technical scheme, the C-shaped bracket is preferably selected as the bracket of the rotary magnet device, the C-shaped bracket can rotate in the C-shaped bracket sleeve, the single side of the rotation angle is less than 50 degrees, and the total rotation angle is less than 100 degrees. The C-shaped support can move to stay at any position in the range, the control precision can reach 1 degree, the control precision is extremely high, and meanwhile, the operation space is greatly improved due to the open structural design.
Drawings
Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
FIG. 2 is a comparison of an experimental group and a control group after an in vitro thrombolytic assay according to an embodiment of the present invention.
Detailed Description
In order to make the technical scheme of the invention better understood by those skilled in the art, the technical scheme of the invention is further described in detail by the following examples, which are only used for illustrating the invention and are not used for limiting the scope of the invention.
Example 1:
a magnetic nanoparticle targeted delivery displacement regulation and control device comprises a C-shaped support 2, a rotary magnet device 1 arranged on the C-shaped support 2 and a moving platform 4 used for controlling the C-shaped support 2 to perform spatial motion. The moving platform 4 is provided with a C-shaped support sleeve 3, the C-shaped support 2 penetrates through the C-shaped support sleeve 3, a motor gear transmission device 5 is arranged in the C-shaped support sleeve 3, and correspondingly, an arc-shaped rack matched with a transmission gear of the motor gear transmission device 5 is arranged on the outer side of the C-shaped support 2. The C-shaped bracket 2 can rotate around the central axis thereof under the driving of the motor gear transmission device 5.
The rotating magnet device 1 is respectively installed at two ends of the C-shaped bracket 2, and the rotating magnet device 1 comprises a rotating motor 7 and a permanent magnet 6 arranged on a shaft of the rotating motor 7. The number of the permanent magnets 6 is even. An even number of permanent magnets 6 are distributed around the machine shaft of the rotating electric machine 7, wherein the NS-steps of two permanent magnets 6 arranged opposite each other are oriented oppositely.
In order to ensure that the permanent magnet 6 can be stably and fixedly arranged on the shaft of the rotating motor 7 and form an included angle with the shaft of the motor 7, a magnet fixing sleeve is used, and the permanent magnet 6 is arranged in the magnet fixing sleeve which is connected with the shaft of the motor 7.
In this embodiment, the permanent magnets 6 are cylindrical magnets, and the central axis of each cylindrical magnet is at an angle of 30 degrees with the shaft of the motor 7. The inclination of the cylindrical magnets relative to the crankshaft of the motor 7 is favorable for the mutual overlapping of the magnetic fields of the cylindrical magnets, and an overlapping point with the strongest magnetic field intensity is formed in space.
The moving platform 4 is a three-axis moving platform, and can realize the movement of the C-shaped support 2 in three-dimensional space of an X axis, a Y axis and a Z axis.
The moving platform 4 is controlled by a stepping motor, can reach the lowest moving stepping speed of 0.05mm/s, and can realize the movement in three directions of up-down, front-back and left-right. Similarly, the motor gear transmission device 5 for controlling the C-shaped bracket 2 to rotate around the central axis thereof also adopts a stepping motor to control the rotation, so that the C-shaped bracket can rotate in the C-shaped bracket sleeve, the single side of the rotation angle is less than 50 degrees, and the total rotation angle is less than 100 degrees. The C-shaped support can move to stay at any position in the range, the control precision can reach 1 degree, and the control precision is extremely high.
Example 2:
a magnetic nanoparticle targeted delivery displacement regulation and control device comprises a support, a rotary magnet device arranged on the support and a moving platform used for controlling the support to perform space motion. The movable platform is provided with a support sleeve, the support penetrates through the support sleeve, a motor gear transmission device is arranged in the support sleeve, correspondingly, a rack portion is arranged in the vertical direction of the support, and the rack portion is matched with a transmission gear of the motor gear transmission device. The support can reciprocate under motor gear drive's drive, can carry out the adjustment of rotatory magnet device and transfer passage distance in vertical direction. The support can be a U-shaped support, so that an arc-shaped rack is arranged on the outer side face of the curved arc portion of the U-shaped support and matched with a transmission gear of the motor gear transmission device, and the position change of the rotary magnet device can be realized.
And the two ends of the bracket are respectively provided with a rotary magnet device, and the rotary magnet device comprises a rotary motor and a permanent magnet arranged on the shaft of the rotary motor. The number of the permanent magnets is 4. The 4 permanent magnets are evenly distributed around the motor shaft, wherein NS stages of two permanent magnets which are oppositely arranged face to each other.
In order to ensure that the permanent magnet can be stably and fixedly arranged on a motor shaft and form an included angle with the motor shaft at a certain angle, a magnet fixing sleeve is used, the permanent magnet is arranged in the magnet fixing sleeve, and the magnet fixing sleeve is connected with the motor shaft.
The included angle between the central axis of the permanent magnet and the shaft of the motor is 30 degrees. The permanent magnets are arranged in an inclined mode relative to the motor shaft, so that magnetic fields of the cylindrical magnets are overlapped, and an overlapping point with the highest magnetic field intensity is formed in space. Is beneficial to the control and aggregation of the magnetic nano-particles.
The technical scheme adopted by the invention can accurately control the spatial position of the rotary magnets and accurately adjust the position of the overlapped point with the strongest spatial magnetic field intensity generated by each rotary magnet, thereby being capable of controlling the motion trail of the magnetic nanoparticles, conveying the magnetic nanoparticles to the specified position or enabling the magnetic nanoparticles to move according to the specified motion trail in the specified range. In order to further illustrate the beneficial effects of the technical scheme, an in vitro thrombolysis experiment and a rabbit carotid thrombolysis experiment are respectively carried out.
Experiment 1:
in vitro thrombolysis experiment: thrombus is constructed in a tube, and the experimental group 101 is a magnetic nanoparticle solution (2 mg/ml,50 ul) and a tissue plasminogen activator (tPA) solution (100 ug/ml,50 ul); control 202 was tPA solution alone (50 ug/ml,100 ul).
The two are respectively placed in the magnetic nanoparticle regulation and control device loaded in the embodiment 1, the nanoparticles can continuously act with thrombus under the regulation and control of the rotating magnetic field, and after the nanoparticles act and control for 180 minutes, as shown in fig. 2, the experimental group 101 can dissolve about 6mm of thrombus, the control group 202 can dissolve about 3mm of thrombus, and the thrombolysis efficiency of the experimental group is improved by 1 time compared with that of the control group.
Experiment 2:
rabbit carotid thrombolytic experiment: and (3) constructing thrombus in the carotid artery of the rabbit, and completely blocking the blood vessel by the thrombus. The experimental group is that the magnetic nanoparticle regulating device loaded in the application example 1 accurately regulates and controls the magnetic nanoparticles (2 mg/ml,100 ul) loaded with tissue plasminogen activator (tPA) to the thrombus part, and dissolves 5mm of thrombus in 180 minutes. Research results show that the magnetic regulation and control device can effectively regulate and control the magnetic nano particles loaded with the tPA to the thrombus position and realize thrombolysis. Can realize the targeted delivery of therapeutic drugs in disease treatment and has better therapeutic effect and application prospect.
In summary, the technical scheme adopted by the invention has the following beneficial effects:
the combination of the support and the moving platform is adopted to control the position of the rotating magnet device in space, so that the movement of the rotating magnetic field generated by the rotating magnet can be realized, and the overlapping of a plurality of rotating magnetic fields in space necessarily has a point with the maximum magnetic field intensity, so that the aggregation of the magnetic nanoparticles at the point can be realized by controlling the specific position of the point, the magnetic nanoparticles can reach any specified position, or the magnetic nanoparticles are controlled to move in a specified space range according to a specified path. The device can obviously improve the action effect of the medicine, after the magnetic nanoparticles are controlled to accurately convey the loaded medicine to the designated position, the device continuously acts, the magnetic nanoparticles continue to move at the designated position, the medicine is uniformly distributed and dispersed, and the treatment effect is improved.
Two groups of rotating magnets are respectively arranged at two ends of the C-shaped support, so that the magnetic field intensity in an action area can be effectively enhanced, and the accurate displacement control of the magnetic nanoparticles in the height direction can be realized. Moreover, through the rotation of adjusting the C-shaped bracket, the relative displacement between the two groups of rotating magnets can also be changed, and the distance between the two groups of rotating magnets and the appointed conveying position relative to the conveying channel can also be changed, so that the generated rotating magnetic field can generate different changes in the magnetic field intensity of the action area, the adjustable range and the adjustment precision can be greatly improved, and the control of the magnetic nanoparticle displacement path is facilitated.
According to the technical scheme, the rotatable C-shaped support is combined with the moving platform, so that the motion trail of the magnetic nanoparticles can be accurately regulated, the control precision is extremely high, targeted delivery of the medicine is facilitated, and the action effect of the medicine can be improved. Meanwhile, the open operation space formed by the C-shaped branch is beneficial to the operation of a doctor.
The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the details of the above embodiments, and various modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the scope of the present invention.
Claims (9)
1. A magnetic nanoparticle targeted delivery displacement regulation and control device is characterized in that: the device comprises a C-shaped support, a rotary magnet device arranged on the C-shaped support and a moving platform used for controlling the C-shaped support to perform space motion.
2. The magnetic nanoparticle targeted delivery displacement modulating device of claim 1, wherein: the movable platform is provided with a C-shaped support sleeve, the C-shaped support penetrates through the C-shaped support sleeve, a motor gear transmission device is arranged in the C-shaped support sleeve, correspondingly, an arc-shaped rack matched with a transmission gear of the motor gear transmission device is arranged on the outer side of the C-shaped support, and the C-shaped support rotates around the central axis of the C-shaped support under the driving of the motor gear transmission device.
3. The magnetic nanoparticle targeted delivery displacement modulating device of claim 1, wherein: and the two ends of the C-shaped bracket are respectively provided with a rotary magnet device, and the rotary magnet device comprises a rotary motor and a permanent magnet arranged on the shaft of the rotary motor.
4. The magnetic nanoparticle targeted delivery displacement modulating device of claim 1, wherein: the mobile platform is a three-axis mobile platform.
5. The device for regulating and controlling the targeted delivery displacement of magnetic nanoparticles according to claim 3, wherein: the number of the permanent magnets is even.
6. The magnetic nanoparticle targeted delivery displacement modulating device of claim 5, wherein: the permanent magnet is arranged in the magnet fixing sleeve, and the magnet fixing sleeve is connected with a motor shaft.
7. The magnetic nanoparticle targeted delivery displacement modulating device of claim 6, wherein: the permanent magnet is a cylindrical magnet, and an included angle is formed between the central axis of the cylindrical magnet and the shaft of the motor.
8. The device for regulating and controlling the targeted delivery displacement of magnetic nanoparticles according to claim 7, wherein: the included angle between the central axis of the cylindrical magnet and the shaft of the motor is 30 degrees.
9. The magnetic nanoparticle targeted delivery displacement modulation device of any one of claims 3-8, wherein: the C-shaped bracket can also be replaced by a U-shaped bracket, and the rotary magnet devices are arranged at two ends of the U-shaped bracket.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110240189.1A CN115245625A (en) | 2021-03-04 | 2021-03-04 | Magnetic nanoparticle targeted delivery displacement regulation and control device |
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| CN202110240189.1A CN115245625A (en) | 2021-03-04 | 2021-03-04 | Magnetic nanoparticle targeted delivery displacement regulation and control device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737815A (en) * | 2022-11-04 | 2023-03-07 | 上海市第六人民医院 | Magnetic regulation and control micro-nano particle device with positioning/treatment function |
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- 2021-03-04 CN CN202110240189.1A patent/CN115245625A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115737815A (en) * | 2022-11-04 | 2023-03-07 | 上海市第六人民医院 | Magnetic regulation and control micro-nano particle device with positioning/treatment function |
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