CN115227968A - Non-invasive stimulation system based on high-frequency time domain interference and electroencephalogram compounding - Google Patents

Non-invasive stimulation system based on high-frequency time domain interference and electroencephalogram compounding Download PDF

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CN115227968A
CN115227968A CN202210577453.5A CN202210577453A CN115227968A CN 115227968 A CN115227968 A CN 115227968A CN 202210577453 A CN202210577453 A CN 202210577453A CN 115227968 A CN115227968 A CN 115227968A
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stimulation
time domain
frequency time
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赵冰蕾
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Shanghai Jiaotong University
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    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
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Abstract

The invention provides a non-invasive stimulation system based on high-frequency time domain interference and electroencephalogram composition, which comprises the following components: the electroencephalogram monitoring system comprises an electroencephalogram cap, an analysis control unit, a high-frequency time domain interference stimulation unit and an electroencephalogram acquisition unit; the brain electricity cap is provided with a plurality of stimulating electrodes; the analysis control unit is used for selecting part of the stimulation electrodes to form at least two TI electrode pairs according to the analysis result of the brain impedance distribution diagram, and other stimulation electrodes are used as EEG electrodes; the high-frequency time domain interference stimulation unit is used for outputting high-frequency time domain signals to the at least two TI electrode pairs to form at least one envelope electric field for stimulation; the electroencephalogram acquisition unit is used for acquiring electroencephalograms under stimulation of high-frequency time domain signals. Has the beneficial effects that: the non-invasive stimulation technology is realized based on high-frequency time domain interference and electroencephalogram, the change of electroencephalogram can be synchronously monitored while stimulation is carried out, the influence of time domain depth stimulation intervention means on brain functions is visually and quantitatively analyzed, the regulation and control effect of the high-frequency time domain interference regulation and control technology is improved, and the positioning accuracy is improved.

Description

Non-invasive stimulation system based on high-frequency time domain interference and electroencephalogram compounding
Technical Field
The invention relates to the technical field of non-invasive stimulation, in particular to a non-invasive stimulation system based on high-frequency time domain interference and electroencephalogram composition.
Background
Compared with invasive Brain Stimulation technology, non-invasive Brain Stimulation (NiBS) technology can transmit electrical Stimulation or magnetic Stimulation signals into the Brain or extract and collect Brain activity signals without an operation, and is often applied to the treatment and health rehabilitation of depression, stroke, sleep disorder and some senile diseases, the research of Brain function, brain network, brain-computer interface and the like.
The non-invasive brain Stimulation techniques mainly include transcranial Electrical Stimulation (tES) and Transcranial Magnetic Stimulation (TMS), etc., and the depth of the tES-type and TMS-type nerve Stimulation is shallow.
TES is divided into transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial random electrical stimulation (tRNS) and the like, the tDCS stimulation range is large, the stimulation electrode sponge is approximately more than 8 square centimeters, the stimulation range possibly spans several brain areas, and the stimulation accuracy is poor. High-precision transcranial electrical stimulation (HD-tDCS) uses 5 small electrodes with the diameter smaller than 12mm for stimulation, improves the accuracy and controllability of electrical stimulation, reduces the requirement on space, needs 5 electrode groups for combined use, and still occupies more electrode positions. tACS addresses some of the spatial resolution issues, but is also primarily stimulated at the superficial brain surface. There are also some side effects of the individual types of tACS.
The H-type transcranial magnetic stimulation TMS can be applied to the deep part of the brain through a special coil, but the superficial epidermal layer of the brain is also affected. Repeated transcranial magnetic stimulation (rTMS) is one of TMS stimulation, and mainly adopts modes such as high-frequency stimulation (HF-rTMS, 5-20 Hz), low-frequency stimulation (LF-rTMS, less than or equal to 1 Hz), intermittent theta burst stimulation (irss), and Continuous theta burst stimulation (cbss), wherein the LF-rTMS and cbss modes can cause cortical suppression, and the HF-rTMS and irss modes can cause cortical excitation, and the size of the stimulation coil is large, but the spatial resolution is still relatively low, which is inconvenient for studying network correlation between similar areas of the brain. Meanwhile, the deep brain region is stimulated, and the superficial brain layer is also affected by stimulation.
Electroencephalograms (EEG) are planar graphs of the relationship between potential and time obtained by recording spontaneous biopotentials in the cerebral cortex of the brain on the scalp in an amplified manner with a precision instrument. The electroencephalogram is composed of basic features such as the frequency (cycle), amplitude, and phase of an electroencephalogram. EEG in combination with tMS or tDCS type technologies requires two problems to be solved: physical compatibility and electrical compatibility. Physical compatibility means that enough space is provided for arranging an electrical stimulation electrode and an electroencephalogram acquisition electrode at the same time, and the electroencephalogram electrodes are arranged as many as possible under the condition of ensuring the normal work of the instrument; the electrical compatibility means that the influence of the electrical stimulation current on the electroencephalogram signal is reduced as much as possible. EEG is stable at 68 channels, and as the number of channels decreases, because of its poor physical compatibility, large electrode area, and low number of electrodes, electroencephalographic analysis may result in erroneous information data.
The high frequency time domain interference (TI) stimulation technology is based on the characteristic that neurons do not respond to high frequency (1 KHz) stimulation, 2 pairs of electrodes are adopted to apply 2 alternating currents with different frequencies respectively to act on the brain together, when two electromagnetic waves with similar frequencies meet at a certain position in the brain, the two electromagnetic waves can be partially coherent and form neural oscillation of an enveloping electric field, so that a neuron group at the position is activated, the frequency of the enveloping electric field is the difference between the two frequencies, and the main advantage of the high frequency time domain interference (TI) stimulation technology is that stimulation can be generated at the deep part of a brain area without generating stimulation on a superficial epidermal layer. But the requirements on the stimulation position, the stimulation intensity and the stimulation time are higher, and the action effect is seriously influenced by the accurate positioning of the stimulation point; the intensity and time of the stimulation directly affect the time of change of the excitability of the cortex after the end of the stimulation, are computationally intensive, complex and take a long time.
Disclosure of Invention
In order to solve the technical problems, the invention provides a non-invasive stimulation system based on high-frequency time domain interference and electroencephalogram composition.
The technical problem solved by the invention can be realized by adopting the following technical scheme:
a non-invasive stimulation system based on high frequency time domain interference and electroencephalogram compounding, comprising:
the brain wave cap is provided with a plurality of warps, a plurality of wefts and a plurality of stimulating electrodes respectively arranged at the connecting parts of the warps and the wefts, and each stimulating electrode is provided with a first mode and a second mode;
the analysis control unit is respectively connected with the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit and is used for analyzing the received brain impedance distribution map, selecting part of the stimulation electrodes to be set to be in the first mode according to the analysis result, forming at least two TI electrode pairs, and setting other stimulation electrodes to be in the second mode to be used as EEG electrodes;
the high-frequency time domain interference stimulation unit is used for outputting a high-frequency time domain signal with a preset frequency and transmitting the high-frequency time domain signal to the at least two TI electrode pairs so that electromagnetic waves generated by the at least two TI electrode pairs are coherent in a preset position region in the deep part of the brain to form at least one enveloping electric field, and further stimulation adjustment is performed through the enveloping electric field;
and the electroencephalogram acquisition unit is used for acquiring the electroencephalogram under the stimulation of the high-frequency time domain signals through the EEG electrodes and generating the brain impedance distribution diagram.
Preferably, the method further comprises the following steps: and the electrode conversion device is connected with the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit and is connected with the warps and the wefts of the electroencephalogram cap through a cable.
Preferably, the analysis control unit includes:
and the evaluation module is used for carrying out evaluation according to the electroencephalogram and outputting a control signal according to an evaluation result so as to control the high-frequency time domain interference stimulation unit or switch the position of the TI electrode and/or the EEG electrode according to the control signal.
Preferably, the high frequency time-domain interferential stimulation unit comprises:
the high-frequency signal generating module is used for generating a high-frequency signal;
the filtering module is connected with the high-frequency signal generating module and is used for carrying out band-pass filtering processing on the high-frequency signal;
the direct current blocking module is connected with the direct current blocking module and used for isolating direct current signals;
and the output adjusting module is connected with the direct current blocking module and used for adjusting the signal output by the direct current blocking module so as to output the high-frequency time domain signal with the preset frequency.
Preferably, the high-frequency time-domain interferential stimulation unit further comprises:
and the recording module is connected with the output adjusting module and is used for recording the recording information related to the operation process of the output adjusting module.
Preferably, the electroencephalogram acquisition unit includes:
the scanning module is used for inputting the high-frequency time domain signal with the preset frequency to the pair of stimulating electrodes of the electroencephalogram cap according to a preset scanning strategy to obtain scanning test data;
and the processing module is connected with the scanning module and used for processing the scanning test data to obtain the brain impedance distribution map under the preset frequency.
Preferably, the preset scanning strategy includes: using one of the stimulation electrodes as a cathode of a TI electrode pair, and sequentially traversing all other stimulation electrodes as anodes of the TI electrode pair;
and switching any one of the other stimulation electrodes to serve as the cathode of the TI electrode pair, sequentially traversing all the other stimulation electrodes to serve as the anodes of the TI electrode pair, and performing the steps until all the stimulation electrodes are traversed to serve as the cathodes of the TI electrode pair.
Preferably, the method further comprises the following steps:
and the power supply module is respectively connected with the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit and is used for respectively providing power for the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit.
Preferably, the high-frequency time-domain interference stimulation unit is further configured to output a feedback signal when the output of the high-frequency time-domain signal is stopped;
further comprising: the distribution module is connected with the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit and used for switching the at least two TI electrode pairs into EEG electrodes when the feedback signals are received;
the electroencephalogram acquisition unit acquires an electroencephalogram under the stimulation of the high-frequency time domain signal through the switched EEG electrode.
Preferably, a unit shielding device is arranged between the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit.
The technical scheme of the invention has the advantages or beneficial effects that:
the non-invasive stimulation technology is realized based on high-frequency time domain interference and electroencephalogram, by introducing the application of the electroencephalogram technology, the change of the electroencephalogram can be synchronously monitored while stimulation is carried out, the influence of time domain depth stimulation intervention means on brain functions is intuitively and quantitatively analyzed, the regulation and control effect of the high-frequency time domain interference regulation and control technology is improved, the purpose of accurately regulating and controlling deep brain target areas is achieved, the stimulation positions are analyzed and fed back in real time before stimulation, and the positioning accuracy is improved.
Drawings
FIG. 1 is a schematic structural diagram of a non-invasive stimulation system based on high-frequency time-domain interference and electroencephalogram compounding in a preferred embodiment of the present invention;
FIG. 2 is a schematic diagram of the structure of the electroencephalogram cap in the preferred embodiment of the present invention;
FIG. 3 is a schematic diagram of the distribution of brain impedance at a predetermined frequency according to the preferred embodiment of the present invention;
FIG. 4 is a block diagram of the high frequency time domain interference stimulation unit and the electroencephalogram acquisition unit in the preferred embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.
It should be noted that the embodiments and features of the embodiments of the present invention may be combined with each other without conflict.
The invention is further described with reference to the following drawings and specific examples, which are not intended to be limiting.
In a preferred embodiment of the present invention, based on the above problems in the prior art, there is provided a non-invasive stimulation system based on high-frequency time domain interference and electroencephalogram composition, which belongs to the technical field of non-invasive stimulation, and as shown in fig. 1, the non-invasive stimulation system includes:
the brain wave cap comprises a brain wave cap 1, wherein the brain wave cap 1 is provided with a plurality of warps, a plurality of wefts and a plurality of stimulating electrodes respectively arranged at the connecting parts of the warps and the wefts, and each stimulating electrode has a first mode and a second mode;
the analysis control unit 8 is respectively connected with the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit and is used for analyzing the received brain impedance distribution diagram, selecting part of stimulation electrodes to be set as a first mode according to an analysis result, forming at least two TI electrode pairs, and setting other stimulation electrodes as second modes to be used as EEG electrodes;
the high-frequency time domain interference stimulation unit 4 is used for outputting a high-frequency time domain signal with a preset frequency, and transmitting the high-frequency time domain signal to the at least two TI electrode pairs 11, so that electromagnetic waves generated by the at least two TI electrode pairs are coherent in a preset position region in the deep part of the brain to form at least one enveloping electric field 9, and further stimulation adjustment is performed through the enveloping electric field;
and the electroencephalogram acquisition unit 5 is used for acquiring an electroencephalogram under stimulation of a high-frequency time domain signal through an EEG electrode and generating a brain impedance distribution map.
Specifically, in this embodiment, the electroencephalogram acquisition unit 5 in the system of the present invention can acquire a brain impedance distribution map in advance, and perform stimulation position positioning, stimulation intensity, and stimulation time determination based on the brain impedance distribution condition, thereby completing time domain stimulation, achieving accurate regulation of a deep brain target area, and improving the positioning accuracy of the envelope; the electroencephalogram acquisition unit 5 can also acquire electroencephalograms afterwards, evaluate the regulating effect of the high-frequency time domain signals on the activities of cerebral neurons, and improve the regulating effect of the TI nerve regulation and control technology.
Specifically, as shown in fig. 2, the electroencephalogram cap 1 includes a plurality of stimulation electrodes, and the stimulation electrodes are connected by wires. The plurality of stimulating electrodes are common electrodes of the TI electrode and the EEG electrode, and if the stimulating electrodes are in a first mode, the stimulating electrodes are used as the TI electrode; if the stimulating electrode is in the second mode, i.e. as an EEG electrode.
Furthermore, the stimulation electrodes are non-magnetic induction carbon-based electrodes, the conducting wires are also non-magnetic induction carbon-based conducting wires, and the carbon-based electrodes and carbon-based (such as graphene, carbon nano tubes, graphite and the like) conducting adhesives form good conducting electric contact, so that an electroencephalogram signal can be improved, the influence of contact resistance is reduced, and meanwhile, the generation of electric noise caused by magnetic, electric and other interferences is avoided.
Furthermore, the analysis control unit 8 can be integrated in a terminal device such as a PC, a mobile phone, etc., and is connected to the high-frequency time-domain interference stimulation unit 4 and the electroencephalogram acquisition unit 5 through the control line 7. Or the command signal can be sent to the high-frequency time-domain interference stimulation unit 4 and the electroencephalogram acquisition unit 5 in a wireless mode.
As a preferred embodiment, the method further comprises the following steps: the electrode conversion device 2 is connected with the high-frequency time domain interference stimulation unit 4 and the electroencephalogram acquisition unit 5, and is connected with a plurality of warps and a plurality of wefts of the computer cap 1 through a cable.
Specifically, the electrode conversion device is respectively connected with the electroencephalogram cap 1, the high-frequency time domain interference stimulation unit 4 and the electroencephalogram acquisition unit 5 through the conductive transmission line 3, and the electrode conversion device 2 is a distribution conversion part of the TI electrode and the EEG electrode and is used for transmitting a high-frequency time domain signal or an electroencephalogram signal to the electroencephalogram cap 1 or extracting a signal from the electroencephalogram cap 1. The part of the conductive transmission line entering the electroencephalogram cap 1 is spliced into a common cable to reduce the number of leads entering the electroencephalogram cap 1, the electrode conversion device separates a part of the conductive transmission line 3 to enter the high-frequency time-domain interference stimulation unit 4, and a part of the conductive transmission line 3 to the electroencephalogram acquisition unit 5.
Further, the conductive transmission line 3 is made of a carbon-based conductive material.
As a preferred embodiment, among others, the analysis control unit 8 includes:
and the evaluation module is used for carrying out evaluation according to the electroencephalogram and outputting a control signal according to the evaluation result so as to control the high-frequency time domain interference stimulation unit 4 or switch the position of the TI electrode and/or the EEG electrode according to the control signal.
Specifically, the system of the invention is based on TI-EEG stimulation and measurement data, and can explore and research the functions of brain areas and associate interaction relations among the brain areas by analyzing stimulation response characteristics afterwards.
As a preferred embodiment, as shown in fig. 4, the high-frequency time-domain interferential stimulation unit 4 comprises:
a high frequency signal generating module 41 for generating a high frequency signal;
the filtering module 42 is connected with the high-frequency signal generating module and is used for carrying out band-pass filtering processing on the high-frequency signals;
a dc blocking module 43 connected to the dc blocking module for isolating the dc signal;
and the output adjusting module 44 is connected to the dc blocking module and is configured to adjust the signal output by the dc blocking module to output a high-frequency time domain signal with a preset frequency.
Specifically, the high-frequency signal generating module 41 is composed of a programming control FPGA, a D/a conversion module, and other functional modules; the filtering module 42 is a band-pass (bandpass) filtering module, and is formed by a multi-order low-pass and high-pass band-pass filter and the like; the DC blocking module 3 is mainly composed of a filter capacitor circuit and the like; the output adjusting module 44 is mainly composed of a constant-current constant-voltage signal adjusting module, a phase adjusting module, an impedance testing and recording module and the like. The high-frequency signal generating module, the filtering module, the direct current blocking module and the output adjusting module are all formed by the existing circuit structure, and are not described herein again.
As a preferred embodiment, the method further comprises the following steps:
and the power supply module 45 is respectively connected with the high-frequency time domain interference stimulation unit 4 and the electroencephalogram acquisition unit 5 and is used for respectively supplying power to the high-frequency time domain interference stimulation unit 4 and the electroencephalogram acquisition unit 5.
Specifically, the power module 45 is used to convert a commercial ac power into voltages (volts) used by the high-frequency time-domain interference stimulation unit 4 and the electroencephalogram acquisition unit 5, respectively. The power module may include a first power circuit for supplying power to the high-frequency time-domain interference stimulation unit 4 and a second power circuit for supplying power to the electroencephalogram acquisition unit 5, or the first power circuit and the second power circuit may be integrated into a whole, and the high-frequency time-domain interference stimulation unit 4 and the electroencephalogram acquisition unit 5 share one power circuit.
Further, the power module 45 may include a transformer, a bridge rectifier circuit and a capacitor filter circuit, and the power module 45 may directly adopt an existing power circuit, which is not described herein again.
As a preferred embodiment, the high-frequency time-domain interference stimulation unit 4 further includes:
a recording module (not shown) connected to the output adjustment module 44 for recording the recording information related to the operation process of the output adjustment module.
Specifically, the recording module may also be integrated in the output adjusting module 44, and during subsequent stimulation adjustment, the recording information may be queried, and the stimulation position, the stimulation intensity, and the stimulation time in the high-frequency time-domain interference stimulation unit 4 may be adjusted to a memory mode, so as to directly perform stimulation adjustment.
As a preferred embodiment, among others, the electroencephalograph acquiring unit 5 includes:
a scanning module (not shown in the figure) for inputting a high-frequency time domain signal with a preset frequency to a pair of stimulation electrodes of the electroencephalogram cap 1 according to a preset scanning strategy to obtain scanning test data;
and the processing module (not shown in the figure) is connected with the scanning module and used for processing the scanning test data to obtain a brain impedance distribution map under a preset frequency.
Specifically, the TI-EEG system of the present invention uses the high-frequency time-domain interference stimulation unit 4 to output a high-frequency time-domain signal of a preset frequency to the stimulation electrode on the electroencephalogram cap 1, and uses the electroencephalogram acquisition unit 5 to test the conductivity of the whole brain, so as to form a brain impedance distribution map, as shown in fig. 3. And according to the individual difference brain impedance distribution condition, the TI electrode position of the high-frequency time domain signal is adjusted, and the electrode position of the envelope electric field is accurately determined, so that the envelope electric field can be effectively formed at the position needing stimulation, and the positioning accuracy of the envelope is improved.
The electroencephalogram acquisition unit 5 may be formed by a relatively mature EEG circuit, for example, the electroencephalogram acquisition unit includes a power isolation module 51, a sampling control module 52, a data processing module 53, and an electroencephalogram acquisition module 54. The power supply adopts a direct current power supply shared by the high-frequency time domain interference stimulation unit 4.
As a preferred embodiment, the preset scanning strategy includes: one stimulation electrode is taken as the cathode of the TI electrode pair, and all other stimulation electrodes are traversed in sequence to be taken as the anodes of the TI electrode pair;
and switching any one of all other stimulation electrodes to be used as the cathode of the TI electrode pair, sequentially traversing all other stimulation electrodes to be used as the anodes of the TI electrode pair, and traversing all the stimulation electrodes to be used as the cathodes of the TI electrode pair according to the step.
Specifically, firstly fixing a cathode position by using a high-frequency time domain signal, sequentially changing the anode position until all stimulating electrodes on the electroencephalogram cap 1 are completely scanned, then changing the second cathode position, and sequentially changing the anode position until all the cathodes are completely scanned; then, the processing module obtains a brain impedance distribution graph under a preset frequency through an algorithm according to all the scanning test data of the test, wherein the preset frequency is the frequency selected to be stimulated.
Specifically, the processing module generates a brain impedance distribution map and then sends the brain impedance distribution map to the analysis control unit 8, the analysis control unit 8 receives the brain impedance distribution map and analyzes the brain impedance distribution situation to obtain the brain impedance distribution situation, two TI electrode pairs formed by 4 stimulation electrodes are selected to serve as electrodes of a brain area needing TI stimulation, other stimulation electrodes serve as EEG electrodes, and based on the EEG and TI combined technology, the positioning accuracy of high-frequency stimulation is improved in the situation that stimulation positions are analyzed and fed back in advance, in real time.
Further, the TI electrode and the EEG electrode are compatible at the same time, i.e. the TI electrode stimulates the brain region, while the EEG electrode acquires the electroencephalogram of the brain region under the stimulation of the enveloping electric field generated by the high frequency time domain signal.
Further, the analysis control unit 8 may select more than two TI electrode pairs to perform multiple brain regions in the brain while forming multiple "envelope electric field" stimuli.
As a preferred embodiment, wherein, the high-frequency time-domain interference stimulation unit 4 is further configured to output a feedback signal when the output of the high-frequency time-domain signal is stopped;
further comprising: the distribution module 46 is connected with the high-frequency time domain interference stimulation unit 4 and the electroencephalogram acquisition unit 5 and is used for switching the at least two TI electrode pairs into EEG electrodes when receiving feedback signals;
specifically, the electroencephalogram can be measured with a delay, that is, the TI electrode pair is switched to the second modality at the moment when the TI stimulation ends, and is used as an EEG electrode, and the electroencephalogram of the brain region under the envelope electric field stimulation generated by the high-frequency time domain signal is collected together with the original EEG electrode.
The electroencephalogram acquisition unit 5 acquires an electroencephalogram under stimulation of the high-frequency time domain signals through the switched EEG electrodes.
In a preferred embodiment, a unit shielding device is disposed between the high-frequency time-domain interference stimulation unit 4 and the electroencephalogram acquisition unit 5.
Specifically, the high-frequency time domain interference stimulation unit 4 and the electroencephalogram acquisition unit 5 can be integrated into one device, due to the high-frequency property of the high-frequency time domain interference stimulation unit 4, a unit shielding device needs to be arranged between the two units, and the lead and the signal source generation device adopt methods such as electromagnetic shielding and the like, so that noise can be reduced, low-noise measurement data can be obtained, and the influence of high-frequency signals on electroencephalogram measurement results is avoided, so that analysis results are influenced.
In the above preferred embodiment, the system of the present invention has the following advantages or benefits:
(1) The system is based on the combination of a high-frequency time domain interference (TI) stimulation technology and an electroencephalogram technology, is convenient to use, and can be used for simultaneously carrying out stimulation and signal acquisition;
(2) An EEG cap 1 of an EEG standard is matched with head stimulation and measurement position positioning, so that an individualized brain impedance distribution diagram can be accurately measured, a TI stimulation electrode pair of a brain area part needing stimulation is intelligently selected according to the brain impedance distribution diagram, parameters such as voltage and current are adjusted, accurate positioning is carried out, an envelope electric field is formed at the position needing stimulation, stimulation (treatment) research is carried out on the corresponding brain area, and the like;
(3) The system can stimulate, record and analyze and feed back the stimulation effect at the same time or in a delayed way, and adjust the stimulation parameters and the like according to the feedback data, thereby improving the regulation and control effect of the TI nerve regulation and control technology;
(4) By the TI-EEG coupling technology, the system can record the electroencephalogram signals with extremely high time resolution, solve the problem that the TMS and tES nerve stimulation depth is shallow, and realize accurate brain deep stimulation;
(5) Through a TI-EEG combined technology, under the assistance of stimulation feedback data based on an electroencephalogram, stimulation parameters of the TI stimulation technology are adjusted, only the positions of deep brain areas needing stimulation are affected, the surface layer of the scalp and other parts are not affected, and the problem that similar H-shaped TMS coils are magnetically stimulated to the deep part of the brain through the skull, but the superficial surface layer of the brain is also affected at the same time is solved; the method has the advantages that the tDCS stimulation range is large, and the stimulation range possibly spans several brain areas, and meanwhile, the problem of poor tDCS stimulation accuracy is solved;
(6) The electrode coverage area of the electroencephalogram cap is standard and wide, and can stimulate and monitor larger brain area activity or brain network activity information, and the physical compatibility problems of extremely large electrodes and more electrodes of tDCS and HD-tDCS stimulation technologies are solved by matching with a TI-EEG combined system;
(7) The stimulation electrode on the electroencephalogram cap gives consideration to the TI electrode and the EEG electrode, the EEG electrode can be used simultaneously or used in a time-delay and alternate mode, the non-magnetic induction carbon-based electrode and the lead are adopted, the lead and the signal source generating device adopt methods such as electromagnetic shielding, and low-noise measurement information can be obtained;
(8) Performing stimulation regulation and control and stimulation response measurement based on a TI-EEG coupling technology, and analyzing and feeding back stimulation positions in real time in advance to realize accurate positioning; the stimulation response characteristics are analyzed afterwards, the functions of the brain areas are researched and researched, the interaction relation among the brain areas is related, and meanwhile, the diagnosis and treatment of nerve and mental diseases and senile degenerative diseases are carried out according to the abnormal response characteristics or the information feedback stimulation of a corresponding external device is researched and controlled as BCI.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention.

Claims (10)

1. A non-invasive stimulation system based on high frequency time domain interference and electroencephalogram compounding is characterized by comprising:
the brain wave cap is provided with a plurality of warps, a plurality of wefts and a plurality of stimulating electrodes respectively arranged at the connecting parts of the warps and the wefts, and each stimulating electrode has a first mode and a second mode;
the analysis control unit is respectively connected with the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit and is used for analyzing a received brain impedance distribution diagram, selecting part of the stimulation electrodes to be set to be in the first mode according to an analysis result, forming at least two TI electrode pairs, and setting other stimulation electrodes to be in the second mode to be used as EEG electrodes;
the high-frequency time domain interference stimulation unit is used for outputting a high-frequency time domain signal with a preset frequency and transmitting the high-frequency time domain signal to the at least two TI electrode pairs so that the electromagnetic waves generated by the at least two TI electrode pairs are coherent in a preset position region in the deep part of the brain to form at least one enveloping electric field, and further stimulation adjustment is carried out through the enveloping electric field;
and the electroencephalogram acquisition unit is used for acquiring the electroencephalogram under the stimulation of the high-frequency time domain signals through the EEG electrodes and generating the brain impedance distribution diagram.
2. The non-invasive stimulation system based on high frequency time domain interferometry and electroencephalography compounding of claim 1, further comprising: and the electrode conversion device is connected with the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit and is connected with the warps and the wefts of the electroencephalogram cap through a cable.
3. The non-invasive stimulation system based on high frequency time domain interferometry and electroencephalography compounding according to claim 1, characterized in that the analysis control unit comprises:
and the evaluation module is used for carrying out evaluation according to the electroencephalogram and outputting a control signal according to an evaluation result so as to control the high-frequency time domain interference stimulation unit or switch the position of the TI electrode and/or the EEG electrode according to the control signal.
4. The non-invasive stimulation system based on high frequency time domain interference and electroencephalogram compounding of claim 1, wherein the high frequency time domain interference stimulation unit comprises:
the high-frequency signal generating module is used for generating a high-frequency signal;
the filtering module is connected with the high-frequency signal generating module and is used for carrying out band-pass filtering processing on the high-frequency signal;
the direct current blocking module is connected with the direct current blocking module and used for isolating direct current signals;
and the output adjusting module is connected with the direct current blocking module and used for adjusting the signal output by the direct current blocking module so as to output the high-frequency time domain signal with the preset frequency.
5. The non-invasive stimulation system based on high frequency time-domain interference and electroencephalogram compounding according to claim 4, wherein the high frequency time-domain interference stimulation unit further comprises:
and the recording module is connected with the output adjusting module and is used for recording the recording information related to the operation process of the output adjusting module.
6. The non-invasive stimulation system based on high frequency time domain interference and electroencephalogram compounding as claimed in claim 1, wherein the electroencephalogram acquisition unit comprises:
the scanning module is used for inputting the high-frequency time domain signal with the preset frequency to the pair of stimulating electrodes of the electroencephalogram cap according to a preset scanning strategy to obtain scanning test data;
and the processing module is connected with the scanning module and used for processing the scanning test data to obtain the brain impedance distribution map under the preset frequency.
7. The high frequency temporal interference and electroencephalogram compounding based noninvasive stimulation system of claim 6, wherein the preset scanning strategy comprises: using one of the stimulation electrodes as a cathode of a TI electrode pair, and sequentially traversing all other stimulation electrodes as anodes of the TI electrode pair;
and switching any one of the other stimulation electrodes to serve as the cathode of the TI electrode pair, sequentially traversing all the other stimulation electrodes to serve as the anodes of the TI electrode pair, and performing the steps until all the stimulation electrodes are traversed to serve as the cathodes of the TI electrode pair.
8. The non-invasive stimulation system based on high frequency time domain interferometry and electroencephalography compounding according to claim 1, further comprising:
and the power supply module is respectively connected with the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit and is used for respectively supplying power to the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit.
9. The non-invasive stimulation system based on high frequency time domain interference and electroencephalogram compounding as claimed in claim 1, wherein the high frequency time domain interference stimulation unit is further configured to output a feedback signal when the output of the high frequency time domain signal is stopped;
further comprising: the distribution module is connected with the high-frequency time domain interference stimulation unit and the electroencephalogram acquisition unit and used for switching the at least two TI electrode pairs into EEG electrodes when the feedback signals are received;
the electroencephalogram acquisition unit acquires an electroencephalogram under the stimulation of the high-frequency time domain signal through the switched EEG electrode.
10. The non-invasive stimulation system based on high frequency time domain interference and electroencephalogram compounding as claimed in claim 1, wherein a unit shielding device is arranged between the high frequency time domain interference stimulation unit and the electroencephalogram acquisition unit.
CN202210577453.5A 2022-05-25 2022-05-25 Non-invasive stimulation system based on high-frequency time domain interference and electroencephalogram compounding Pending CN115227968A (en)

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