CN115227215A

CN115227215A - Resonance respiration-based non-invasive vagal nerve stimulation method and related device

Info

Publication number: CN115227215A
Application number: CN202210893778.4A
Authority: CN
Inventors: 秦伟; 孙金铂; 龙戈农; 王聪
Original assignee: Xi'an Keyue Medical Technology Co ltd
Current assignee: Xi'an Keyue Medical Technology Co ltd
Priority date: 2022-07-27
Filing date: 2022-07-27
Publication date: 2022-10-25
Also published as: WO2024021364A1

Abstract

The application is applicable to the technical field of medical treatment, and provides a resonance respiration-based non-invasive vagal nerve stimulation method and a related device, which are used for improving the stimulation effect of the non-invasive vagal nerve stimulation method in the prior art on the vagal nerve activity of a human body. The method mainly comprises the following steps: determining a resonance respiratory frequency of a user, wherein the resonance respiratory frequency is a respiratory frequency corresponding to the user in a resonance respiratory state; outputting, to the user at the resonant breathing frequency, non-invasive vagal stimulation that conforms to the resonant breathing frequency.

Description

Resonance respiration-based non-invasive vagal nerve stimulation method and related device

Technical Field

The application belongs to the technical field of medical treatment, and particularly relates to a resonance respiration-based noninvasive vagus nerve stimulation method and a related device.

Background

The vagus nerve (vagus nerve) is the tenth cranial nerve in humans and is also a major component of the parasympathetic nervous system. The vagus nerve is emitted from the brain stem, distributed to internal organs such as external ear, heart, lung, stomach, intestine, etc., and plays an important role in maintaining the homeostasis of the internal environment of the body. From the fibrous component, the vagus nerve belongs to the mixed nerve. On one hand, the vagus nerve carries a large amount of visceral information to enter the central nervous system through afferent fibers, and influences the central autonomic nerve network and nervous circuits such as emotion and cognition through an ascending afferent pathway, so that the effects of relieving tension and anxiety emotion, improving cognitive function and the like are generated; on the other hand, the vagus nerve, through efferent fibers, affects down the functions of the organs of the heart, lung, stomach, intestine and other internal organs, and has the effects of reducing heart rate, improving gastrointestinal digestive function and the like. Therefore, high vagal activity is considered a healthy manifestation.

Non-invasive vagal nerve stimulation (tVNS) is a neuromodulation technique for enhancing vagal nerve activity. The non-invasive vagus nerve stimulation is to apply electric pulse to vagus nerve through a skin electrode, the activity of vagus nerve can be enhanced through the electric pulse, and the non-invasive vagus nerve stimulation can be safe and widely applied to sub-health people and disease people.

The resonance respiration refers to the phenomenon that the heart rate oscillation caused by respiration is consistent with the heart rate oscillation caused by vasoconstriction (or blood pressure change) in frequency to present resonance, and experiments show that whether the current respiration frequency of a user is the resonance respiration frequency can be determined by monitoring the change degree of the heart rate variability. The resonance breathing frequency refers to the breathing frequency of the user when resonance breathing is caused; heart Rate Variability (HRV) refers to the variation between heart beats and heart beats. The blood pressure contraction frequency of the vasoconstriction is coincident with the frequency of heart rate oscillations it causes, approximately 4 to 7 beats per minute. However, when the user breathes naturally, the heart rate oscillation frequency caused by vasoconstriction (or blood pressure change) is different from the heart rate oscillation frequency, phase, and the like caused by respiration, and is represented by small and irregular heart rate oscillation amplitude, and at this time, the effect of non-invasive vagus nerve stimulation on the human body to improve the vagus nerve activity is relatively limited.

Disclosure of Invention

The objective of the present application is to provide a resonance respiration-based non-invasive vagal nerve stimulation method and related device, aiming to improve the stimulation effect of the non-invasive vagal nerve stimulation method in the prior art on the vagal nerve activity of a human body.

In a first aspect, the present application provides a method of resonance breathing-based noninvasive vagal stimulation comprising:

determining a resonance breathing frequency of a user, wherein the resonance breathing frequency is a breathing frequency corresponding to the user in a resonance breathing state;

outputting to the user at the resonant breathing frequency non-invasive vagal stimulation consistent with the resonant breathing frequency.

Optionally, the determining the resonant breathing frequency of the user comprises:

monitoring the current heart rate variability and the current respiratory rate of a user;

directing the user to adjust the current respiratory rate;

determining the current respiratory rate as the user's resonant respiratory rate when the current respiratory rate causes a change in the heart rate variability of the user that exceeds a preset threshold.

Optionally, the guiding the user to adjust the current breathing frequency comprises:

guiding the user to adjust the current breathing rate in a perceivable manner, the perceivable manner including one or more of a visual guide, an audible guide, and a tactile guide.

Optionally, the resonant breathing frequency comprises: a universal resonant breathing frequency or a personal resonant breathing frequency;

the universal resonant breathing frequency is a breathing frequency corresponding to when the user exhibits a heart rate oscillation of 6 beats/minute;

the individual resonance breathing frequency is the individualized breathing frequency corresponding to the user when the user enters resonance breathing.

Optionally, the monitoring the current heart rate variability of the user comprises:

collecting the current electrocardiosignal or the photoplethysmography signal of the user;

and calculating to obtain the current heart rate variability of the user according to the electrocardio signals or the photoplethysmography signals.

Optionally, the acquiring the current cardiac electric signal or the current photoplethysmographic pulse wave signal of the user includes:

acquiring a current physiological signal of the user through a physiological signal acquisition electrode, wherein the physiological signal comprises the electrocardiosignal or the photoplethysmography signal;

detecting a contact state of the physiological signal collecting electrode with the skin of the user;

when the contact state of the physiological signal acquisition electrode and the skin of the user is good, sending out a signal prompt indicating that the physiological signal acquisition electrode and the skin of the user are in good contact;

and when the contact state of the physiological signal acquisition electrode and the skin of the user is poor contact, sending out a signal prompt indicating that the physiological signal acquisition electrode and the skin of the user are poor in contact.

Optionally, the detecting the contact state of the physiological signal collecting electrode with the skin of the user comprises:

detecting a human body impedance value of the user through the physiological signal acquisition electrode;

judging whether the human body impedance value exceeds a preset threshold value or not;

if the human body impedance value exceeds the preset threshold value, determining that the physiological signal acquisition electrode is in poor contact with the skin of the user;

and if the human body impedance value is equal to or lower than the preset threshold value, determining that the physiological signal acquisition electrode is in good contact with the skin of the user.

Optionally, after determining that the physiological signal collecting electrode is in poor contact with the skin of the user, the method comprises:

when the non-invasive vagus nerve stimulation conforming to the resonance breathing frequency is output to the user, stopping the step of outputting the non-invasive vagus nerve stimulation conforming to the resonance breathing frequency to the user and issuing a warning.

In a second aspect, the present application provides a resonance respiration-based non-invasive vagal nerve stimulation system comprising:

the device comprises a determining unit, a processing unit and a processing unit, wherein the determining unit is used for determining the resonance breathing frequency of a user, and the resonance breathing frequency is the breathing frequency corresponding to the user in a resonance breathing state;

an output unit for outputting to the user at the resonant breathing frequency non-invasive vagal stimulation consistent with the resonant breathing frequency.

Optionally, when determining the resonant breathing frequency of the user, the determining unit is specifically configured to:

directing the user to adjust the current respiratory rate;

Optionally, the determining unit is configured to, when guiding the user to adjust the current respiratory rate, specifically:

Optionally, when the determining unit monitors the current heart rate variability of the user, it is specifically configured to:

Optionally, when the determining unit acquires the current cardiac electrical signal or photoplethysmographic pulse signal of the user, the determining unit is specifically configured to:

the detection unit is used for detecting the contact state of the physiological signal acquisition electrode and the skin of the user;

the prompting unit is used for sending out a signal prompt indicating that the physiological signal acquisition electrode is in good contact with the skin of the user when the contact state of the physiological signal acquisition electrode and the skin of the user is good;

and the prompting unit is also used for sending out a signal prompt indicating that the physiological signal acquisition electrode is in poor contact with the skin of the user when the contact state of the physiological signal acquisition electrode and the skin of the user is in poor contact.

Optionally, when the detection unit detects a contact state of the physiological signal collecting electrode and the skin of the user, the detection unit is specifically configured to:

the judging unit is used for judging whether the human body impedance value exceeds a preset threshold value or not;

the determining unit is further used for determining that the physiological signal collecting electrode is in poor contact with the skin of the user if the human body impedance value exceeds the preset threshold value;

the determining unit is further used for determining that the physiological signal collecting electrode is in good contact with the skin of the user if the human body impedance value is equal to or lower than the preset threshold value.

Optionally, the system includes:

and a stopping unit for stopping the execution of the step of outputting the non-invasive vagal nerve stimulation corresponding to the resonance breathing frequency to the user and giving a warning when the non-invasive vagal nerve stimulation corresponding to the resonance breathing frequency is output to the user.

In a third aspect, the present application provides a computer device comprising:

the system comprises a processor, a memory, a bus, an input/output interface and a network interface;

the processor is connected with the memory, the input/output interface and the network interface through a bus;

a program is stored in the memory;

the processor, when executing the program stored in the memory, implements a method of noninvasive vagus nerve stimulation according to any one of the preceding first aspects.

In a fourth aspect, the present application provides a computer-readable storage medium having instructions stored therein, which when executed on a computer, cause the computer to perform a method of non-invasive vagal nerve stimulation as set forth in any one of the preceding first aspects.

In a fifth aspect, the present application provides a computer program product which, when executed on a computer, causes the computer to perform the method of non-invasive vagal nerve stimulation as set forth in any one of the preceding first aspects.

According to the technical scheme, the embodiment of the application has the following advantages:

the resonance respiration-based noninvasive vagus nerve stimulation method comprises the steps of firstly determining the resonance respiration frequency of a user so that the subsequent steps can carry out corresponding noninvasive vagus nerve stimulation according to the resonance respiration frequency, wherein the resonance respiration frequency is the corresponding respiration frequency when the user is in a resonance respiration state; and then, non-invasive vagus nerve stimulation conforming to the resonance breathing frequency is output to the user, so that the heart rate oscillation of the user in the resonance breathing state caused by breathing is consistent with the heart rate oscillation frequency caused by vasoconstriction (or blood pressure change), a resonance phenomenon is generated, and at the moment, the non-invasive vagus nerve stimulation conforming to the resonance breathing frequency is output to the user, so that the stimulation effect of the non-invasive vagus nerve stimulation method on the activity of the vagus nerve of the human body can be effectively improved.

Drawings

FIG. 1 is a schematic flow diagram illustrating one embodiment of a resonance breathing based non-invasive vagal stimulation method of the present application;

FIG. 2 is a schematic flow diagram illustrating another embodiment of a resonance breathing-based non-invasive vagal nerve stimulation method of the present application;

FIG. 3 is a schematic block diagram illustrating an embodiment of a resonance breathing based non-invasive vagal stimulation system according to the present application;

FIG. 4 is a schematic structural diagram illustrating another embodiment of a resonance breathing based non-invasive vagal stimulation system according to the present application;

FIG. 5 is a schematic structural diagram of an embodiment of a computer apparatus of the present application;

FIG. 6 is a schematic diagram of one embodiment of a network framework for the resonance breathing based non-invasive vagal stimulation method of the present application;

FIG. 7 is a schematic diagram illustrating the functional block partitioning of an embodiment of the hardware apparatus of the present application for implementing a resonance breathing based non-invasive vagal nerve stimulation method;

FIG. 8 is a schematic diagram illustrating an interface display effect of an embodiment of a target mobile terminal according to the present application;

FIG. 9 is a graph illustrating the monitoring of physiological parameters of a user before entering a resonance breathing state, during entering the resonance breathing state, and after leaving the resonance breathing state.

Detailed Description

In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of and not restrictive on the broad application.

Non-invasive vagal nerve stimulation (tVNS) is a neuromodulation technique for enhancing vagal nerve activity. The non-invasive vagus nerve stimulation applies electric pulse to vagus nerve through the skin electrode, effectively enhances the activity of vagus nerve, is safe and non-invasive, and is widely suitable for sub-health people and disease people. Recent studies have found that non-invasive vagal stimulation can modulate heart rate variability, producing the effects of reducing heart rate and enhancing HRV. The resonance respiration refers to the phenomenon that the heart rate oscillation caused by respiration is consistent with the heart rate oscillation caused by vasoconstriction (or blood pressure change) in frequency to present resonance, and whether the current respiration frequency of the user is the resonance respiration frequency can be determined by monitoring the change degree of the heart rate variability. The resonance breathing frequency refers to a breathing frequency when the user is in a resonance breathing state. The Heart Rate Variability (HRV) refers to the variation between heartbeats, can represent the variation degree between adjacent heartbeats, and is an noninvasive detection means for quantitatively evaluating the autonomic nervous regulation function of the Heart.

In the following, how to determine the resonant breathing frequency of a user through heart rate variability in the prior art is briefly described, please refer to fig. 9, fig. 9 is a graph of relevant physiological parameters obtained by monitoring various physiological indexes of a human body of the user through a monitoring device, and relevant data of fig. 9 is referred to in a document entitled "Characteristics of physiology in heart rate variability contaminated by biohazard dback", which is cited in a format: (Vaschillo EG, vaschillo B, lehrer PM. Characteristics of resources in heart rate variability expressed by bio feedback. Appl Psychology Biofeedback.2006;31 (2): 129-142. Doi). For example, the physiological signal collecting electrode is connected to a corresponding position of the skin of a user, the user is guided to perform slow breathing, large-amplitude movement is avoided as far as possible, the slow breathing test time is about 2 minutes generally, then the physiological signal of the user is fed back through the physiological signal collecting electrode to calculate data information such as heart rate variability, breathing frequency, heart rate and the like of the user, and when the current breathing frequency of the user causes the change of the heart rate variability exceeding a preset threshold value, the current breathing frequency is determined to be the resonance breathing frequency of the user. After a plurality of tests, the user can accurately find the self resonance breathing frequency. The first row in the three column three row graph of fig. 9 represents: the time profile of the respiration of a user with 6 heart rate oscillations per minute; the first column of the three-column three-row graph in fig. 9 represents the second row: heart rate versus time for the user at 6 heart rate oscillations per minute; the first and third rows of the three-row three-column graph of fig. 9 represent: a frequency variation degree curve of heart rate variability of the user with 6 heart rate oscillations per minute; the second column of the first row of the three column three row graph of fig. 9 represents: a plot of respiration versus time for a user at 5.5 heart rate oscillations per minute; the second column, second row diagram in the three column, three row diagram of fig. 9 represents: heart rate versus time for the user at 5.5 heart rate oscillations per minute; the second column, third row of the three column plot of fig. 9 represents: a frequency variation degree curve of heart rate variability of the user with 5.5 heart rate oscillations per minute; the second column, third row of the three column plot of fig. 9 represents: a frequency variation degree curve of heart rate variability of the user with 5.5 heart rate oscillations per minute; the third column of the three-row graph in fig. 9 represents the first row: a plot of respiration versus time for a user at 5 heart rate oscillations per minute; the third column of the three-column line graph of fig. 9 represents: heart rate versus time for the user at 5 heart rate oscillations per minute; the third column, third row of the three column graph of fig. 9 represents: frequency variation degree curve of heart rate variability of the user in case of 5 heart rate oscillations per minute. As can be seen in fig. 9: under the condition that the heart rate of a user of the user oscillates for 5.5 times every minute, the frequency of the heart rate variability of the user is greatly changed, so that the user can be considered to enter a resonance breathing state at the moment, and the breathing frequency corresponding to the user is the resonance breathing frequency at the moment. Relevant studies have shown that most people have a breathing rate of 12 to 20 beats per minute, a heart rate oscillation rate caused by the breathing rate of about 4 to 7 beats per minute, and most people enter a resonance breathing state with a corresponding heart rate oscillation rate of about 6 beats per minute.

The variability of heart rate can be used as an objective index to assess vagal activity, with increased variability of heart rate indicating increased vagal function. Neuroscience research proves that: vagal activity is closely linked to respiratory activity, and its response fluctuates periodically as a result of the individual's own respiratory rhythm. The extrinsic manifestations of vagal activity closely linked to respiratory activity are: when inhaling, the vagus nerve activity is inhibited, the heart rate is accelerated, and the heart rate variability is reduced; vagal inhibition is released during exhalation, vagal activity is restored, heart rate slows down, and heart rate variability increases. Thus, application of vagal stimulation at a particular phase of the respiratory cycle, such as application of electrical impulse stimulation during the expiratory phase, may enhance the effectiveness of vagal stimulation. The breathing rate is generally compatible with the number of normal human breaths per minute, i.e., a breath includes one inhalation and one exhalation. Heart rate refers to the number of beats per minute of a normal person in a resting state. The non-invasive vagus nerve stimulation conforming to the resonance respiratory frequency is output to the user in the resonance respiratory state, so that the stimulation effect of the non-invasive vagus nerve stimulation method on the activity of the vagus nerve of the human body can be effectively improved. Referring to fig. 6, the network framework of the resonance respiration-based noninvasive vagal nerve stimulation method of the present application includes: hardware devices 610 for implementing non-invasive vagal stimulation, a target mobile terminal 620, a local backend server 630, a cloud server 640. The hardware device 610 is generally connected to the local backend server 630 through a wired network, the hardware device 610 is generally connected to the target mobile terminal 620 and the cloud server 640 through a wireless network, the target mobile terminal 620 is generally connected to the local backend server 630 and the cloud server 640 through a wireless network, and the local backend server 630 and the cloud server 640 are generally connected through a wired network or a wireless network. For example: the wireless communication mode is one or more of communication modes such as a Bluetooth network, a WiFi network, a 2G/3G/4G/5G network and the like, and the wired network connection can be one or more of standard interface communication modes such as an optical fiber, a USB and the like. It should be noted that, the number of the hardware device 610, the target mobile terminal 620, the local backend server 630, and the cloud server 640 for implementing the non-invasive vagus nerve stimulation may be multiple, which is only one illustrated here, and in practical applications, a combination and a selection of a number of the hardware devices may be performed as needed.

Specifically, referring to fig. 7, fig. 7 is a functional block diagram of a hardware device 610 for implementing a resonance breathing-based noninvasive vagus nerve stimulation method according to the present application, the hardware device comprising: physiological signal acquisition module 611, physiological signal processing module 612, processor 613, vagal nerve stimulation module 614, breathing guidance module 615, interaction module 616, body impedance detection module 617, and warning module 618. The physiological signal acquisition module 611 acquires physiological signals of the user 700, such as an electrocardiosignal, a respiratory signal, a photoplethysmographic signal, an electroencephalographic signal and the like, through acquisition electrodes arranged on the user 700; the physiological signal acquisition module 611 transmits the physiological signal acquired from the user 700 to the physiological signal processing module 612, the physiological signal processing module 612 converts the physiological signal acquired from the physiological signal acquisition module 612 from an analog signal to a digital signal, and performs real-time analysis on the physiological signal of the digital signal, for example, the physiological signal processing module 612 can analyze a respiratory phase of the user 700 from a respiratory signal, analyze a heartbeat R peak of the user 700 from an electrocardiographic signal, and the like, and meanwhile, the physiological signal processing module 612 can calculate a series of physiological parameters of the user 700, such as a heart rate, a heart rate variability, an electrocardiographic-electroencephalogram coupling, and the like, according to the physiological signal fed back by the physiological signal acquisition module 611;

the processor 613 is generally a Micro Controller Unit (MCU), which is also called a Single Chip Microcomputer (Single Chip Microcomputer) or a Single Chip Microcomputer, and is configured to receive a series of physiological parameters reported by the physiological information processing module 612 and forward the series of physiological parameters to the respiratory guidance module 615; the processor 613 is further configured to receive a confirmation signal that the user enters the resonance breathing state, which is reported by the interaction module 616, and further the processor 613 controls the vagal nerve stimulation module 614 to output an adapted electrical impulse to the user; the processor 613 is further configured to receive a human impedance value of the user 700 acquired by the human impedance detection module 617, and generally, the acquisition electrode of the human impedance detection module 617 is integrated with the acquisition electrode of the physiological signal acquisition module, so as to ensure proper connection of the acquisition electrode during use by detecting the human impedance value of the user, thereby ensuring signal quality to a certain extent; the warning module 618 is configured to issue a warning in time when the hardware device 610 fails (for example, the processor 613 determines that the human impedance detection module 617 detects that the human impedance value suddenly fluctuates greatly, and may be that the collecting electrode makes poor contact with the human body, etc.), so as to perform a warning function; the breathing guidance module 615 can guide the user to breathe with a specific frequency according to preset parameters (such as breathing frequency, inspiration/expiration ratio, inspiration/expiration end breath holding time and the like), and output various types of guidance such as visual guidance, auditory guidance or tactile guidance and the like through the interaction module 616; the case interaction module 616 integrates communication sub-modules (bluetooth, wiFi, RJ-45, etc.), a display screen, a key (touch pad), a speaker, a vibration motor, etc., the communication sub-modules are used for being in communication connection with the target mobile terminal 620, the local server 630, the cloud server 640, etc., the display screen, the key, the speaker, the vibration motor, etc., are used for performing visual guidance, auditory guidance or tactile guidance, etc., on site, for the user, and the interaction module 616 realizes the interaction between the user and the hardware device 610; vagal stimulation module 614 may output electrical impulses and adjust stimulation parameters according to user settings, such as: parameters such as stimulation mode (Burst/sonic), frequency (Hz), pulse width (us), single/double phase, stimulation duration, output current intensity and the like are adjusted, and the output current intensity of hardware equipment for implementing the resonance respiration-based noninvasive vagus nerve stimulation method is adjustable between 0 and 6 mA.

It is noted that when the user performs a communication connection with the hardware device 610 for implementing the resonance respiration-based noninvasive vagal stimulation method through the target mobile terminal 620 (typically, a smart terminal such as a mobile phone or a tablet), the user typically interacts with the user through a software Application (APP) on the target mobile terminal 620, and the user can perform a series of functions such as setting parameters, controlling the hardware device 610, and analyzing the acquired physiological signals through networking through a corresponding software application on the target mobile terminal 620. In guiding the user into the resonance breathing state, the software application of the target mobile terminal 620 may also output one or more of visual guidance, audible guidance, tactile guidance, such as diversified breathing guidance forms including light music, mini-games, etc., to meet the user's needs in different contexts. In addition, the software application of the target mobile terminal 620 can receive the physiological signal sent by the hardware device 610 through the interaction module 616 in real time, and calculate a series of indexes such as heart rate, heart rate variability, electrocardio-electroencephalogram coupling and the like which can indicate the activity of the vagus nerve through the target mobile terminal 620, so that the computational expenditure of the hardware device 610 is reduced. Referring to fig. 8, fig. 8 shows an example of an interface display effect of the target mobile terminal 620, where the upper half area 621 shows an electrocardiographic waveform and a heart rate, the lower half area 622 shows a respiration guidance waveform (solid line) and an actual respiration waveform (dotted line) and a phase coupling degree of the two waveforms, when the coupling degree is increased to above 90%, it is considered that the user enters a resonance respiration state, and then a confirmation signal is generated when the button 623 for starting stimulation is clicked, the target mobile terminal 620 sends the confirmation signal to the hardware device 610, the hardware device 610 receives the confirmation signal through the interaction module 616, and the processor 613 controls the vagus nerve stimulation module 614 to apply an electric pulse to the human body of the user during an exhalation phase. In addition, the software application of the target mobile terminal 620 can synchronize the usage records of the hardware device 610, and connect with the background server 630 and the cloud server 640 to perform synchronous storage, management and calculation of data, so as to provide better usage experience for the user.

Based on the above understanding, referring to fig. 1, one embodiment of the resonance breathing based non-invasive vagal nerve stimulation method of the present application comprises:

101. and determining the resonance respiratory frequency of the user, wherein the resonance respiratory frequency is the respiratory frequency corresponding to the user in the resonance respiratory state.

This step requires determining the resonant breathing frequency of the user performing the non-invasive vagal stimulation to ensure that the user can be brought to the breathing state of operation, and the subsequent step may perform the corresponding non-invasive vagal stimulation according to the resonant breathing frequency. For example, the working breathing frequency may be a universal resonant breathing frequency or a personal resonant breathing frequency, where the universal resonant breathing frequency is a breathing frequency when most users exhibit a resonant breathing state, such as a breathing frequency corresponding to a heart rate oscillation of 6 beats/minute (i.e., 6bpm or 0.1 Hz) when the users exhibit, and the universal resonant breathing frequency has universality and is suitable for most users; the individual resonance breathing frequency is the individualized breathing frequency corresponding to the resonance breathing of the user, the individual resonance breathing frequency is different from person to person, the individual resonance breathing frequency can be obtained only by the user through detection similar to the embodiment of the figure 9, individuation is achieved, and the effect is better when non-invasive vagus nerve stimulation is subsequently carried out.

102. Non-invasive vagal stimulation is output to the user that corresponds to the resonant breathing frequency.

After determining the resonant breathing frequency of the user in step 101, this step outputs non-invasive vagal stimulation corresponding to the resonant breathing frequency by the electrode to the user. For example, electrical pulse stimulation with a preset current intensity is applied to an electrode applied to the skin of the vagus nerve of the user during the exhalation phase of the user, so that the vagus nerve stimulation effect can be further improved.

Therefore, the resonance respiration-based noninvasive vagus nerve stimulation method determines the resonance respiration frequency of the user, wherein the resonance respiration frequency is the respiration frequency corresponding to the user in the resonance respiration state, so that the subsequent steps can perform corresponding noninvasive vagus nerve stimulation according to the resonance respiration frequency; and then, non-invasive vagus nerve stimulation conforming to the resonance respiratory frequency is output to the user, so that the heart rate oscillation caused by respiration of the user in the resonance respiratory state is consistent with the heart rate oscillation caused by vasoconstriction (or blood pressure change), a resonance phenomenon is generated, and at the moment, the non-invasive vagus nerve stimulation conforming to the resonance respiratory frequency is output to the user, so that the stimulation effect of the non-invasive vagus nerve stimulation method on the activity of the vagus nerve of the human body can be effectively improved.

Referring to fig. 2, another embodiment of the resonance breathing based non-invasive vagal stimulation method of the present application includes:

201. monitoring the current heart rate variability and the current respiratory rate of the user.

In this step, the current physiological signal of the user may be acquired through a physiological signal acquisition electrode, where the physiological signal may include an electrocardiographic signal or a photoplethysmographic pulse wave signal, then the current heart rate variability of the user is obtained through calculation according to the electrocardiographic signal or the photoplethysmographic pulse wave signal, and the heart rate variability of the user through calculation of the electrocardiographic signal or the photoplethysmographic pulse wave signal is the prior art, and is not described herein too much. For example, by attaching the collecting electrode of the hardware device 610 described above to the skin surface of a specific location of the vagus nerve of the user, the various physiological signals of the user can be collected by activating the hardware device 610 through the physiological signal collecting module 611. In practical applications, it is a mature prior art that a chest strap or other manners can be used to collect physiological signals such as a respiratory signal of a user, then the current respiratory frequency of the user is calculated according to the respiratory signal, and the calculation of the current respiratory frequency of the user according to the respiratory signal is not described herein. It should be noted that the physiological signal is collected in this step without limitation.

202. The user is guided to adjust the current breathing rate in a manner that can be perceived.

In order to effectively guide the user to adjust the current breathing rate, the step may guide the user to adjust the current breathing rate in a manner that can be perceived by one or more of visual guidance, auditory guidance and tactile guidance. The process of guiding the user to adjust the breathing frequency in a manner of perception can be carried out by an interactive module of the hardware device for carrying out the non-invasive vagus nerve stimulation, and can also be carried out by the target mobile terminal. When the step is executed by the target mobile terminal, the hardware equipment needs to send the heart rate, the respiratory rate and the like to the target mobile terminal, and then the target mobile terminal guides the user to adjust the respiratory rate in a manner of being perceived.

203. And when the current respiratory frequency causes the change that the heart rate variability of the user exceeds a preset threshold value, determining the current respiratory frequency as the resonance respiratory frequency of the user.

It will be appreciated that the resonant breathing frequency of different users is usually different, and that the heart rate variability of a user will vary greatly as the current breathing frequency of the user approaches the resonant breathing frequency. In the step, a preset threshold value can be set for the change value of the heart rate variability, and as long as the current respiratory frequency causes the change of the heart rate variability of the user exceeding the preset threshold value, the current respiratory frequency is considered as the resonance respiratory frequency of the user, namely the resonance respiratory frequency can be considered as a range value, so that the resonance respiratory frequency of the user can be determined quickly.

204. Non-invasive vagal stimulation is output to the user that corresponds to the resonant breathing frequency.

After determining the resonant breathing frequency of the user in step 203, this step may output non-invasive vagal stimulation corresponding to the resonant breathing frequency via the electrodes to the user. For example, electrical pulse stimulation with a preset current intensity is applied to an electrode applied to the skin of the vagus nerve of the user during the exhalation phase of the user, so that the vagus nerve stimulation effect can be further improved.

In another embodiment, this step may further receive a confirmation signal that the user enters the resonance breathing state, so as to avoid an automated misoperation of hardware equipment, and effectively control the non-invasive vagal stimulation to the user. For example, the step may first receive a confirmation signal from the target mobile terminal or the interaction module of the hardware device that the user enters the resonance breathing state, and then output the non-invasive vagal stimulation corresponding to the resonance breathing frequency to the user.

205. Judging whether the human body impedance value exceeds a preset threshold value, and if the human body impedance value exceeds the preset threshold value, executing step 207; if it is determined that the human body impedance value does not exceed the preset threshold, step 206 is executed.

In step 201, when the current physiological signal of the user is collected by the physiological signal collecting electrode, the contact state of the physiological signal collecting electrode and the skin of the user may also be detected, for example, the human impedance value of the user is detected by the physiological signal collecting electrode, and when the human impedance value detected by the physiological signal collecting electrode exceeds a preset threshold, it indicates that the physiological signal collecting electrode may be in poor contact with the skin of the user; when the physiological signal collecting electrode detects that the impedance value of the human body does not exceed the preset threshold value, the physiological signal collecting electrode is indicated to be well contacted with the skin of the user, and the physiological signal collecting electrode which is well contacted can be used for ensuring the quality of physiological signal collection. Similarly, the electrical pulse stimulation electrode of the vagus nerve stimulation module can be used for detecting the human body impedance value of the user, and when the electrical pulse stimulation electrode detects that the human body impedance value exceeds the preset threshold value, the electrical pulse stimulation electrode is possibly in poor contact with the skin of the user; when the electric pulse stimulation electrode detects that the impedance value of the human body does not exceed the preset threshold value, the electric pulse stimulation electrode is indicated to be well contacted with the skin of a user, and the electric pulse stimulation electrode with good contact can be used for ensuring the quality of electric pulse stimulation.

206. And sending out a good contact signal.

When it is determined in step 205 that the impedance value of the human body does not exceed the preset threshold, it indicates that the contact between the physiological signal collecting electrode and the skin of the user and the contact between the electrical pulse stimulating electrode and the skin of the user are good, and this step may send a signal prompt indicating that the contact between the physiological signal collecting electrode and the skin of the user and the contact between the electrical pulse stimulating electrode and the skin of the user are good. For example, visual prompt is carried out through a green prompt on the screen of the target mobile terminal, voice prompt is normally carried out through connection of a loudspeaker playing electrode, and the like.

207. And sending out a signal indicating poor contact.

When it is determined in step 205 that the human body impedance value exceeds the preset threshold, indicating that the physiological signal collecting electrode and the electrical pulse stimulating electrode are in poor contact with the skin of the user, this step may send a signal prompt indicating that the physiological signal collecting electrode and the electrical pulse stimulating electrode are in poor contact with the skin of the user. For example, a visual prompt is performed through a red prompt on a screen of the target mobile terminal, and a voice prompt is performed when the connection of a loudspeaker playing electrode is abnormal.

208. Stopping the step of outputting the non-invasive vagal stimulation consistent with the resonance breathing frequency to the user and issuing a warning.

When the impedance value of the human body exceeds the preset threshold value in step 207, the stimulation current for performing the vagus nerve stimulation in step 204 may mainly flow to the skin surface of the user, rather than entering the vagus nerve, so that the electrical pulse stimulation is stopped when the impedance value of the human body is too large, thereby ensuring safe use and improving the effectiveness of the vagus nerve stimulation. Meanwhile, a warning is sent in the step, the warning can be in a red warning color and character reminding mode through a screen of the target mobile terminal, voice reminding is conducted through a loudspeaker, and the like, and the warning mode is not limited.

Therefore, the method leads the user to enter the resonance respiration state, so that the frequency of the heart rate oscillation caused by respiration of the user in the resonance respiration state is consistent with the frequency of the heart rate oscillation caused by vasoconstriction (or blood pressure change), a resonance phenomenon is generated, at the moment, the non-invasive vagus nerve stimulation conforming to the resonance respiration frequency is output to the user, and the stimulation effect of the non-invasive vagus nerve stimulation method on the activity of the vagus nerve of the human body can be effectively improved.

Relevant parameters of the hardware device may be set when non-invasive vagal stimulation is output to the user that corresponds to the target breathing frequency phase. If the current parameter is different from the last time, resetting the following parameters: respiration-related parameters (respiratory frequency, inspiration/expiration ratio, end inspiration/expiration breath-hold time), vagus nerve stimulation-related parameters (stimulation mode, frequency, pulse width, single/bi-phase, stimulation duration) and associated parameters such as phase of stimulation output relative to respiration, stimulation time in each respiratory cycle, etc. for the phase of stimulation relative to respiration, the expiratory phase is generally recommended to improve vagus nerve stimulation effect. The stimulation intensity can also be adjusted according to the self feeling of the user, and the proper stimulation intensity can be found for adjustment.

The foregoing embodiments describe the resonance respiration-based non-invasive vagal stimulation method, and in the following, the resonance respiration-based non-invasive vagal stimulation system, with reference to fig. 3, an embodiment of the resonance respiration-based non-invasive vagal stimulation system includes:

a determining unit 301, configured to determine a resonance breathing frequency of a user, where the resonance breathing frequency is a breathing frequency corresponding to a resonance breathing state of the user;

an output unit 302 for outputting non-invasive vagal nerve stimulation corresponding to the resonance breathing frequency to the user at the resonance breathing frequency.

The operation of the non-invasive vagus nerve stimulation system based on resonance respiration according to the embodiment of the present application is similar to that of the embodiment of fig. 1, and will not be described herein again.

Referring to fig. 4, another embodiment of a resonance breathing based non-invasive vagal nerve stimulation system includes:

a determining unit 401, configured to determine a resonance breathing frequency of a user, where the resonance breathing frequency is a breathing frequency corresponding to a resonance breathing state of the user;

an output unit 402 for outputting to the user at the resonance breathing frequency a non-invasive vagal stimulation that corresponds to the resonance breathing frequency.

Optionally, when determining the resonant breathing frequency of the user, the determining unit 401 is specifically configured to:

directing the user to adjust the current respiratory rate;

when the current respiratory frequency causes a change in the heart rate variability of the user that exceeds a preset threshold, determining the current respiratory frequency as the resonant respiratory frequency of the user.

Optionally, when the determining unit 401 guides the user to adjust the current breathing frequency, the determining unit is specifically configured to:

Optionally, when the determining unit 401 monitors the current heart rate variability of the user, it is specifically configured to:

Optionally, when the determining unit 401 acquires the current cardiac electric signal or the current photoplethysmography signal of the user, it is specifically configured to:

a detection unit 403 for detecting a contact state of the physiological signal collecting electrode with the skin of the user;

a prompting unit 404, configured to send a signal prompt indicating that the physiological signal collecting electrode is in good contact with the skin of the user when the contact state of the physiological signal collecting electrode with the skin of the user is good contact;

the prompting unit 404 is further configured to send a signal prompt indicating that the contact between the physiological signal collecting electrode and the skin of the user is poor when the contact state between the physiological signal collecting electrode and the skin of the user is poor.

Optionally, when the detecting unit 403 detects a contact state between the physiological signal collecting electrode and the skin of the user, the detecting unit is specifically configured to:

a judging unit 405, configured to judge whether the human body impedance value exceeds a preset threshold;

the determining unit 401 is further configured to determine that the physiological signal collecting electrode is in poor contact with the skin of the user if the human body impedance value exceeds the preset threshold;

the determining unit 401 is further configured to determine that the physiological signal collecting electrode is in good contact with the skin of the user if the human body impedance value is equal to or lower than the preset threshold.

Optionally, the system includes:

a stopping unit 406, configured to stop performing the step of outputting the non-invasive vagal stimulation corresponding to the resonance breathing frequency to the user and issue a warning when the non-invasive vagal stimulation corresponding to the resonance breathing frequency is output to the user.

The operation of the non-invasive vagal stimulation system based on resonance breathing according to the embodiment of the present application is similar to that of the embodiment of fig. 2, and will not be described herein again.

The resonance respiration-based noninvasive vagus nerve stimulation system determines the resonance respiration frequency of a user, wherein the resonance respiration frequency is the corresponding respiration frequency when the user is in a resonance respiration state, so that the subsequent steps can perform corresponding noninvasive vagus nerve stimulation according to the resonance respiration frequency; and then, non-invasive vagus nerve stimulation conforming to the resonance breathing frequency is output to the user, so that the heart rate oscillation of the user in the resonance breathing state caused by breathing is consistent with the heart rate oscillation frequency caused by vasoconstriction (or blood pressure change), a resonance phenomenon is generated, and at the moment, the non-invasive vagus nerve stimulation conforming to the resonance breathing frequency is output to the user, so that the stimulation effect of the non-invasive vagus nerve stimulation method on the activity of the vagus nerve of the human body can be effectively improved.

Referring to fig. 5, a computer device according to an embodiment of the present application is described below, where an embodiment of the computer device according to the present application includes:

the computer device 500 may include one or more processors (CPUs) 501 and a memory 502, where the memory 502 stores one or more applications or data. Wherein memory 502 is volatile storage or persistent storage. The program stored in memory 502 may include one or more modules, each of which may include a sequence of instructions operating on a computer device. Still further, the processor 501 may be configured to communicate with the memory 502 to execute a series of instruction operations in the memory 502 on the computer device 500. The computer device 500 may also include one or more network interfaces 503, one or more input-output interfaces 504, and/or one or more operating systems, such as Windows Server, mac OS, unix, linux, freeBSD, etc. The processor 501 may perform the operations performed in the embodiments shown in fig. 1 to fig. 2, which are not described herein again.

In the several embodiments provided in the embodiments of the present application, it should be understood by those skilled in the art that the disclosed system, apparatus and method may be implemented in other ways. For example, the above-described apparatus embodiments are merely illustrative, and for example, the division of the unit is only one type of logical functional division, and other divisions may be realized in practice, for example, multiple units or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or units, and may be in an electrical, mechanical or other form.

In addition, functional units in the embodiments of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit. The integrated unit, if implemented in the form of a software functional unit and sold or used as a stand-alone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present application may be substantially implemented or contributed to by the prior art, or all or part of the technical solution may be embodied in a software product, which is stored in a storage medium and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device) to execute all or part of the steps of the method of the embodiments of the present application. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a read-only memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and the like.

The above description is only for the purpose of illustrating the preferred embodiments of the present application and is not to be construed as limiting the present application, and any modifications, equivalents, improvements, etc. made within the spirit and scope of the present application should be included in the present application.

Claims

1. A resonance breathing-based non-invasive vagal stimulation method, comprising:

outputting, to the user at the resonant breathing frequency, non-invasive vagal stimulation that conforms to the resonant breathing frequency.

2. The method of noninvasive vagal stimulation according to claim 1, wherein the determining a resonant breathing frequency of the user comprises:

directing the user to adjust the current respiratory rate;

3. The non-invasive vagal stimulation method of claim 2, wherein guiding the user to adjust the current breathing frequency comprises:

4. The method of noninvasive vagal stimulation according to claim 1, wherein the resonant breathing frequency comprises: a universal resonant breathing frequency or a personal resonant breathing frequency;

the universal resonant breathing frequency is the breathing frequency corresponding to the user exhibiting a heart rate oscillation of 6 beats/minute;

5. The non-invasive vagal stimulation method of claim 2, wherein said monitoring the user's current heart rate variability comprises:

6. The non-invasive vagal nerve stimulation method of claim 5, wherein acquiring the user's current cardiac electrical signal or photoplethysmographic signal comprises:

when the contact state of the physiological signal acquisition electrode and the skin of the user is good, sending a signal prompt indicating that the physiological signal acquisition electrode and the skin of the user are in good contact;

and when the contact state of the physiological signal acquisition electrode and the skin of the user is poor contact, sending out a signal prompt indicating that the physiological signal acquisition electrode and the skin of the user are poor contact.

7. The method of noninvasive vagal stimulation according to claim 6, wherein detecting the contact state of the physiological signal collecting electrode with the skin of the user comprises:

8. The non-invasive vagal nerve stimulation method of claim 7, wherein after determining that the physiological signal acquisition electrode is in poor contact with the user's skin, the method comprises:

9. A resonance respiration-based non-invasive vagal stimulation system, comprising:

the determining unit is used for determining the resonance breathing frequency of a user, wherein the resonance breathing frequency is the breathing frequency corresponding to the user in a resonance breathing state;

10. A computer device, comprising:

a program is stored in the memory;

the processor, when executing the program stored in the memory, implements a method of noninvasive vagal stimulation as recited in any of claims 1-8.