CN115223743A - Partition type animal irradiation experimental device - Google Patents
Partition type animal irradiation experimental device Download PDFInfo
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- CN115223743A CN115223743A CN202110421440.4A CN202110421440A CN115223743A CN 115223743 A CN115223743 A CN 115223743A CN 202110421440 A CN202110421440 A CN 202110421440A CN 115223743 A CN115223743 A CN 115223743A
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
- G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K5/00—Irradiation devices
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K5/00—Irradiation devices
- G21K5/08—Holders for targets or for other objects to be irradiated
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Abstract
The invention discloses a partition type animal irradiation experimental device, which fully considers the characteristics of a punctiform irradiation source, arranges an irradiation box which can simultaneously accommodate a plurality of experimental animals in the same group around the irradiation source, can ensure that the irradiation dose which can be received by the animals in the same group is uniform, and ensures the accuracy and reliability of the experimental result; the irradiation box is divided into independent compartments with different quantities by the partition boards with adjustable quantity, and meanwhile, the height of the irradiation box is adjusted by the cover board with adjustable position, so that the compartments with different heights and lengths can be formed, and the irradiation box is suitable for irradiation experimental animals with different body types and different volumes, especially suitable for rats and mice. The device has fewer components, simple structure, low processing and manufacturing cost and very simple and convenient operation, adjustment or cleaning and maintenance.
Description
Technical Field
The invention belongs to the field of radiology and biology, and particularly relates to an animal irradiation experimental device for experimental animal research.
Background
Ambient ionizing radiation (e.g. radiation), radioisotopes (e.g. of the type described above) 60 Co), etc. can cause the occurrence and the death of acute radiation diseases of people, and has great significance and application value in researching the radiation damage mechanism of organisms and developing radiation protection medicaments. Furthermore, malignant tumors are one of the important diseases that currently endanger human health, and constitute the most serious threat to human survival due to the efficacy and effects of radiation therapyThe cost benefit is significant, so that the method becomes a common cancer treatment method, and more than 70 percent of tumor patients need to be treated by radiation treatment to different degrees. Because radiotherapy inevitably damages normal tissues and organs while inhibiting or killing tumor cells, and brings pain to patients and even causes death, the mechanism of radioactive damage and the development of radioprotective drugs are often verified by animal irradiation experiments through animal models before entering human clinical experiments.
In animal irradiation experiments, small animals such as mice and rats are often used as experimental subjects. When an irradiation experiment is carried out, mice and rats in the same group or with the same irradiation dose are often placed in a corresponding irradiation device for irradiation. However, due to the characteristics of strong mobility and difficulty in matching of mice and rats, the mice and the rats are prone to freely move in the device and cannot be fixed. During radiation, the absorption dose of the mouse is inversely proportional to the square of the distance, so that the distance from the mouse to the radioactive source plays a decisive role in the radiation dose, and the distance between the mouse and the radioactive source cannot be consistent, so that the irradiated dose of the mice in the same group has a large error, and finally, the experimental result is not ideal.
For this reason, some improvements have been made in the prior art for animal irradiation experimental devices:
for example, the patent of chinese utility model with publication number CN201977959U discloses a mouse fixing device, which comprises a base, a clamping groove and a mouse holding tube, wherein the clamping groove is fixedly arranged on the base, the clamping groove is matched with the mouse holding tube, the mouse holding tube is fixedly arranged in the clamping groove, and the inner tube of the mouse holding tube can accommodate a mouse; wherein, a mouse tube cover is arranged in the mouse tube and can slide back and forth in the mouse tube; the size of the narrow space formed by the mouse containing pipe and the mouse containing pipe cover can be adjusted through the difference of the position of the mouse containing pipe cover in the mouse containing pipe, namely, the mouse containing pipe cover is fixed in the mouse containing pipe through a clamping bolt inserted in a clamping bolt hole on the mouse containing pipe. The utility model discloses a volume adjustment of well mouse is realized through adjusting mouse pipe lid position in dress mouse pipe, because the rat volume is 6 ~ 8 times of mouse volume usually, and not only the body length is longer, and its size is also bigger, if only adjust the position of mouse pipe lid, can not place the rat in the dress mouse pipe that holds the mouse, therefore, this means that the device only can be used to the irradiation mouse. Furthermore, if the device is modified to a rat holding device, the rat holding tube size will be larger, and if one wants to place a mouse in the rat holding tube that holds the rat, the mouse will not be held, and therefore the modified device can only be used to irradiate the rat. In a word, the utility model discloses an animal fixing device can't compatible rat and mouse. The mouse tube is frequently replaced, so that the operation is complicated, and the service life of the clamping groove is easily shortened; the different mouse-holding tube types have large difference, and the clamping groove is easy to lose effectiveness; in addition, the fixation of each mouse in the device requires the adjustment of the clamp back and forth, which is time-consuming.
For another example, chinese utility model patent with the publication number CN 204181735U discloses a fixing device for irradiation experiments of small animals such as rats and mice, the structure of which includes a bottom plate, a plurality of parallel grooves are provided on the bottom plate, a base capable of moving along the grooves is provided in each groove, a mouse containing tube is provided on the base through a fixing mechanism, a tube cover with adjustable depth is provided in the mouse containing tube, each base can be fixed at any position in the groove, and a plurality of bases are arranged in an arc shape. The utility model discloses a through being convex range with fixed animal when shining to guarantee the homogeneity of illuminated dose. Like aforementioned mouse fixing device, this utility model volume adjustment of well dress mouse pipe is realized putting in the dress mouse through the adjustment mouse pipe lid, and consequently the device can't compatible rat and mouse need frequently change the dress mouse pipe of different models in the use, complex operation, and the dress mouse pipe is inefficacy easily with the fixed establishment of base. In addition, the base is relatively large in volume, and is inconvenient in actual operation.
For another example, the chinese patent application with publication number CN 103565537A discloses a mouse irradiation disc fixing device, which comprises a chassis and a top cover arranged on the chassis, wherein the chassis is a concentric circle structure composed of a circular outer edge and a circular inner edge, a plurality of partition plates are arranged between the circular outer edge and the circular inner edge to divide the chassis into mouse intervals with equal size, and the circular outer edge of the chassis is uniformly provided with a plurality of partition platesThe height-adjustable block cards are provided with oval rat drilling holes on the top cover, and push-pull baffles with sealing functions are arranged at the adjacent positions of the rat drilling holes. Through set up a plurality of baffles on the concentric circles chassis to set up a plurality of bed hedgehopping cards of adjustable height at the outer edge of chassis, for concentric circles range when making the mouse irradiated, the position is also unanimous, in order to guarantee the homogeneity of irradiated dose. The application is to determine the size of the internal space of the fixing device by adjusting the height of the heightening card at one time, so that the fixing device is matched with the body type of a mouse and is firmly fixed. Due to the containing space which is matched with the body type of the mouse and is firmly fixed, the mouse cannot be contained only by adjusting the height of the heightening card. Thus the device is also incompatible with rats and mice. Moreover, mice had a chance to escape from the bed-jig during the experiment. In addition, the device has poor air permeability, and the volume and the number of the used animals are limited by the characteristics of the device. Furthermore, with the device of this application, if it is desired to irradiate all animals simultaneously at once, the radiation source must be positioned above the fixture. Generally, the X-ray irradiation source may be disposed above the fixing device, however, a commonly used point-like irradiation source, for example, 137 the Cs-gamma rays are typically placed in a central location with the animal holding device surrounding the irradiation source, and the irradiation source cannot be placed above the animal holding device. The device of the patent application is therefore only suitable for X-ray irradiation sources and not for point-like irradiation sources.
In conclusion, the existing irradiation devices have complex components and complicated operation, can only be used for the irradiation experiment of a mouse, and cannot be well and compatibly applied to the irradiation experiment of rats or other experimental animals.
Disclosure of Invention
In view of this, the invention provides a partitioned animal irradiation experimental device, which adopts a dot-shaped irradiation source, can be suitable for both rats and mice, can ensure that the irradiation dose which can be received by the same group of animals is uniform, and can ensure the accuracy and reliability of the experimental result.
In order to achieve the above object, the present invention adopts the following technical solutions:
an isolated animal irradiation experimental apparatus, comprising: an irradiation source and an irradiation box, wherein the irradiation source is a point-shaped irradiation source,
the irradiation box is a cuboid irradiation box and consists of left and right end surfaces, front and rear side walls and a bottom surface, and the top surface is open;
a plurality of horizontal cover plate inlets and outlets are arranged at different heights on a first end surface (a left end surface or a right end surface) of the irradiation box;
a plurality of parallel first grooves are arranged on the inner bottom surface of the irradiation box at intervals, and the first grooves are parallel to the rectangular short edge of the bottom surface of the irradiation box;
a plurality of vertical second grooves are arranged on the inner walls of the front side wall and the rear side wall of the irradiation box at intervals, and the second grooves are vertical to the bottom surface of the irradiation box; the positions of the second grooves arranged on the front side wall and the rear side wall of the irradiation box are in one-to-one correspondence, and each group of one-to-one corresponding second grooves is vertically connected with one first groove;
a plurality of horizontal third grooves are arranged on the inner walls of the front side wall and the rear side wall of the irradiation box in parallel, and the positions of the third grooves arranged on the front side wall and the rear side wall of the irradiation box are in one-to-one correspondence; the height of each third groove in the vertical direction corresponds to the height of each cover plate inlet and outlet;
in addition, the block-type animal irradiation experimental apparatus further comprises:
the partition plates are inserted into the first grooves and clamped with the second grooves on two sides, so that the irradiation box is divided into a plurality of compartments, and the compartments are used for accommodating experimental animals; and
the cover plate is used for being inserted into the third groove through the cover plate inlet and outlet to form clamping connection, so that the irradiation box is closed; the top surface of the cover plate is provided with a plurality of groups of vent holes for air circulation.
In an embodiment of the present invention, the partitioned animal irradiation experimental apparatus further includes: the point-like radiation source is 137 Cs or 60 Co。
In a specific example of the present invention, the irradiation cassette is disposed around the irradiation source.
In a specific example of the present invention, the irradiation cassette is one or more.
In a specific embodiment of the invention, the experimental animal is a rat or a mouse.
In a specific example of the present invention, a plurality of horizontal grooves are disposed at different heights on a second end surface (a right end surface or a left end surface) of the irradiation box, the number of the grooves is the same as that of the cover plate inlets and outlets, and the heights of the grooves correspond to the heights of the cover plate inlets and outlets one by one; the first end of the cover plate is provided with a first bulge, the first bulge is matched with the groove, the first bulge is inserted into the groove to form clamping connection, and therefore the irradiation box is more firmly sealed.
In an embodiment of the invention, the distance between any two adjacent first grooves is equal, and the distance between any two adjacent second grooves on the same sidewall is equal.
In an embodiment of the present invention, a second protrusion extending outward is disposed on a second end surface (a right end surface or a left end surface) of the irradiation cassette, and the second protrusion can be used as a handle of the irradiation cassette, so that the irradiation cassette is convenient to move and carry.
In a specific example of the present invention, the irradiation box, the partition board and the cover board are all made of high transparent polypropylene material, which is convenient for the experimental animal to receive irradiation and is also convenient for observing the state of the experimental animal in the irradiation box.
In an embodiment of the present invention, the number of the cover plate ports is two or more.
In one embodiment of the invention, the closure is a push-pull closure.
In one embodiment of the present invention, the sets of ventilation holes are uniformly spaced on the top surface of the cover plate.
In a specific example of the present invention, each set of the vent holes comprises 16 small vent holes and 1 large vent hole, and the small vent holes are distributed radially around the large vent holes.
In an embodiment of the present invention, when the cover plate completely covers the irradiation box, a vertical projection of a large vent hole in each set of vent holes on the bottom surface of the irradiation box is located at a center of a bottom surface of a minimum compartment, where two partition plates are inserted into two adjacent first grooves.
In one embodiment of the present invention, the number of the partition plates is adjusted according to the size of the experimental animal.
In one embodiment of the present invention, the number of the partition plates is 11 or 2.
In one embodiment of the present invention, the partition is provided with a mark.
In a specific example of the present invention, the outer wall of the front side wall or the rear side wall of the irradiation box is provided with a mark.
In the partition type animal irradiation experimental device, the characteristics of the dot-shaped irradiation sources are fully considered, the irradiation boxes capable of accommodating a plurality of experimental animals in the same group are arranged around the irradiation sources, the uniform irradiation dose which can be received by the animals in the same group can be ensured, and the accuracy and the reliability of the experimental results are ensured; the irradiation box is divided into independent compartments with different quantities by the partition boards with adjustable quantity, and meanwhile, the height of the irradiation box is adjusted by the cover board with adjustable position, so that the compartments with different heights and lengths can be formed, and the irradiation box is suitable for irradiation experimental animals with different volumes and different body types, especially suitable for rats and mice. The device has fewer components, simple structure, low processing and manufacturing cost and very simple and convenient operation, adjustment or cleaning and maintenance.
Compared with the prior art, the invention has the following beneficial technical effects:
(1) According to the invention, a plurality of animals in the same group are fixed in the same irradiation box, so that the consistency of the distance between the animals and the radiation source is ensured, and the uniformity of absorbed dose is ensured.
(2) Through the quantity of adjusting the insertion baffle and the position of apron, the animal homoenergetic of different volumes is fixed in irradiation arrangement, consequently, the irradiation animal is mouse or rat, and the homoenergetic uses same irradiation experimental apparatus, fully satisfies the demand of different irradiation experiments.
(3) The air vent that sets up on the apron top surface has guaranteed that the animal is normally breathed in the experimentation, greatly reduced the influence of other factors to the experiment.
(4) According to the invention, a plurality of animals, such as 12 mice or 3 rats, can be simultaneously fixed in a single irradiation box at one time, so that one or more groups of differently treated animals can be simultaneously irradiated, the experiment efficiency is improved, and the experiment cost is reduced.
(5) The invention has the advantages of few components, simple structure, convenient use, very simple operation and adjustment, easy disassembly and convenient cleaning.
Drawings
Fig. 1 is a schematic diagram of a first block type animal irradiation experimental device of the invention.
Fig. 2 is a schematic structural exploded view of a first block-type animal irradiation experimental apparatus (irradiation source not shown) according to the present invention.
Fig. 3 is a front view of a first block-type animal irradiation experimental apparatus (irradiation source not shown) of the present invention.
Fig. 4 is a top view of a cover plate in the first block-type animal irradiation experimental apparatus of the present invention.
Fig. 5 is a schematic view of a state of use of a cover plate in a partitioned animal irradiation experimental apparatus according to a first embodiment of the present invention.
Fig. 6A and 6B are front views of a rat spacer and a mouse spacer in a partitioned animal irradiation experiment apparatus according to a first aspect of the present invention.
Fig. 7A and 7B are schematic views of two states of an uncovered cover plate and a covered cover plate in a first application example of the block-type animal irradiation experiment apparatus of the present invention.
Fig. 8A and 8B are schematic views of two states of an uncovered cover plate and a covered cover plate in a second application example of the block-type animal irradiation experiment apparatus of the present invention.
Detailed Description
In order to better explain the present invention and facilitate the understanding of the technical solutions of the present invention, the present invention is further described in detail below with reference to the specific embodiments and the accompanying drawings. It should be understood that the following examples are illustrative only and do not represent or limit the scope of the present invention, which is defined by the claims.
As shown in figure 1, a partition type animal irradiation experimental device comprises an irradiation source and an irradiation box, wherein the irradiation source is a punctiform irradiation source 137 Cs, in a central position, with the irradiation capsule disposed about the irradiation source. The irradiation box can be one or a plurality of irradiation boxes.
Wherein, the irradiation box is shown in fig. 2 and 3:
the irradiation box 1 is a cuboid box, a plane formed by the edges of the cuboid where the length and the height are located is the front side wall and the rear side wall of the irradiation box 1, a plane formed by the edges of the cuboid where the width and the height are located is the left end surface and the right end surface of the irradiation box 1, and a plane formed by the edges of the cuboid where the length and the width are located is the bottom surface and the top surface of the irradiation box 1 (the top surface of the irradiation box 1 is open), so that the irradiation box 1 is formed by the left end surface, the right end surface, the front side wall, the rear side wall and the bottom surface, and the top surface is open;
a plurality of horizontal cover plate inlets and outlets 7 are arranged at different heights on a first end surface (both a left end surface and a right end surface, and the right end surface in the figure 2) of the irradiation box 1;
a plurality of parallel first grooves 8 are arranged on the inner bottom surface of the irradiation box 1 at intervals, and the first grooves 8 are parallel to the rectangular short edge of the bottom surface of the irradiation box 1;
a plurality of vertical second grooves 9 are arranged on the inner walls of the front side wall and the rear side wall of the irradiation box 1 at intervals, and the second grooves 9 are vertical to the bottom surface of the irradiation box 1; the positions of the second grooves 9 arranged on the front side wall and the rear side wall of the irradiation box 1 are in one-to-one correspondence (namely, the positions of the second grooves 9 arranged on the front side wall of the irradiation box 1 are in one-to-one correspondence with the positions of the second grooves 9 arranged on the rear side wall of the irradiation box 1), and each group of one-to-one corresponding second grooves 9 are vertically connected with one first groove 8 (namely, a certain second groove 9 on the front side wall is vertically connected with a certain first groove 8 to form a right angle, and a second groove 9 on the corresponding rear side wall is also vertically connected with the first groove 8 to form a right angle);
a plurality of horizontal third grooves 6 are arranged in parallel on the inner walls of the front and rear side walls of the irradiation box 1, and the positions of the third grooves 6 arranged on the front and rear side walls of the irradiation box 1 are in one-to-one correspondence (that is, the positions of the third grooves 6 arranged on the front side wall of the irradiation box 1 and the positions of the third grooves 6 arranged on the rear side wall of the irradiation box 1 are in one-to-one correspondence); a plurality of bayonets are formed at the intersection of each third groove 6 and each second groove 9; the height of each third groove 6 in the vertical direction corresponds to the height of the cover plate inlet and outlet 7;
in addition, the partition type animal irradiation experimental device also comprises a partition plate 3 and a cover plate 4, wherein,
a partition 3, as shown in fig. 6A or fig. 6B, for inserting into the first groove 8 and clamping with the second grooves 9 on both sides, thereby dividing the irradiation box 1 into a plurality of compartments for accommodating experimental animals, such as rats or mice;
the cover plate 4 is used for being inserted into the third groove 6 through the cover plate access 7 to form clamping connection, so that the irradiation box 1 is closed; the top surface of the cover plate 4 is provided with a plurality of groups of vent holes 5 for air circulation.
It should be noted that, in fig. 2, a plurality of horizontal grooves 10 are provided at different heights on a second end surface (either a right end surface or a left end surface, or the other end surface opposite to the end surface where the cover plate access 7 is located, or the left end surface in fig. 2) of the irradiation cassette 1, the number of the grooves 10 is the same as that of the cover plate access 7, and the positions of the grooves 10 (or the heights of the grooves 10) correspond to the positions of the cover plate access 7 (or the heights of the cover plate access 7) one by one.
In fig. 2 and 4, a first protrusion 11 is provided at the first end of the cover plate 4, the first protrusion 11 is used to match with the groove 10, when the cover plate 4 is inserted into the third recess 6 through the cover plate access opening 7, the cover plate is pushed forward until the first protrusion 11 is inserted into the groove 10, and the clamping is formed, so that the irradiation box 1 is more firmly closed.
However, it will be understood by those skilled in the art that the first protrusion 11 and the groove 10 are not necessary, and the cover plate 4 is directly inserted into the third groove 6, so that the sealing function of the irradiation cassette 1 can be realized. The clamping of the first protrusion 11 with the groove 10 can make the closing of the irradiation box 1 more secure.
Similarly, in fig. 2, a second protrusion 2 extending outward is further disposed on a second end surface (either a right end surface or a left end surface, or the other end surface opposite to the end surface where the access port of the cover plate is located, or the left end surface in fig. 2) of the irradiation box 1, and can be used as a handle of the irradiation box 1, which is convenient for moving and carrying.
It will also be understood by those skilled in the art that the second protrusion 2 is not necessary, and may be provided with a protrusion as shown in fig. 2, or may not be provided, and does not affect the implementation of the function of the irradiation experimental apparatus.
Those skilled in the art can understand that, in the partition type animal irradiation experimental apparatus, the irradiation box 1, the partition plate 3 and the cover plate 4 can be made of high transparent polypropylene (HTPP) materials, which is convenient for the experimental animal to receive irradiation and is also convenient for observing the state of the experimental animal in the irradiation box 1.
As can be understood by those skilled in the art, in the partition type animal irradiation experimental apparatus, the cover plate 4 is a push-pull cover plate, after the irradiated animals are all put into each compartment, the first end of the cover plate 4 is inserted from the cover plate access 7 until the first protrusion 11 of the cover plate 4 is clamped with the groove 10, and the irradiation box 1 forms a relatively closed space; after the irradiation experiment is finished, the cover plate 4 is pushed to be taken out. Fig. 5 is a schematic view of the use state of the cover plate 4.
Those skilled in the art can understand that, in the above partitioned animal irradiation experimental apparatus, the number of the cover plate inlets and outlets 7 is two or more, and the cover plate 4 is adjusted to be inserted into the third groove 6 from the cover plate inlets and outlets 7 with different heights as required, so as to form independent compartments with different volumes, so as to meet the needs of experimental animals with different body sizes, and the apparatus can be compatible with different experimental animals. Although fig. 3 only shows the case where the cover plate 4 is clamped with the third groove 6 from the cover plate access 7 at the top to close the irradiation box 1, those skilled in the art will understand that the cover plate 4 can also be clamped with the third groove 6 at the corresponding height from the cover plate access 7 at other heights to close the irradiation box 1.
Moreover, it can be understood by those skilled in the art that when there are two or more cover plate inlets and outlets 7, there are two or more grooves 10 at different heights on the second end surface of the irradiation box 1, and if the cover plate 4 is inserted into the third groove 6 at a higher height to form a snap-fit connection and form a closed irradiation box 1, the cover plate inlet and outlet 7 and the grooves 10 at a lower height can play a role of ventilation; alternatively, matching projections may be used to plug the cover plate port 7 and the channel 10 to achieve closure.
It will be understood by those skilled in the art that, in the above-mentioned block-type animal radiation experimental apparatus, the air vents 5 are uniformly spaced on the top surface of the cover plate 4 (or the air vents 5 are equidistantly spaced on the top surface of the cover plate 4.)
Further, each set of the vent holes 5 may be a combination of 16 small vent holes and 1 large vent hole, wherein the 16 small vent holes are radially distributed around the large vent hole.
Further, it is also possible to provide: when the cover plate 4 completely covers the irradiation box 1, the vertical projection of the large vent holes in each set of vent holes 5 on the bottom surface of the irradiation box 1 is located at the center of the bottom surface of the smallest compartment, which is formed by inserting two partition plates 3 into two adjacent first grooves 8.
It can be understood by those skilled in the art that, in the above-mentioned partitioned animal irradiation experimental apparatus, the partitions 3 with different heights can be matched as required, for example, if it is a mouse, the mouse partition 3 with a suitable height can be selected (as shown in fig. 6B), and the cover plate 4 is inserted into the cover plate inlet and outlet 7 with a corresponding height to form a closed independent compartment; for example, in the case of rats, a rat partition 3 (as shown in fig. 6A) with a suitable height can be selected and a cover 4 can be inserted through a cover access opening 7 with a corresponding height to form a closed independent compartment.
As will be understood by those skilled in the art, in the partitioned animal irradiation experimental apparatus, the number of the partition boards 3 is adjusted according to the size of the animal body, and may be set to 11 or 2, for example.
As will be understood by those skilled in the art, in the partitioned animal irradiation experimental facility, the partition 3 may be provided with marks, such as numerical marks, and the partition 3 may be marked with a marker pen for marking animal groups. Of course, such a marking may also be provided on the outer wall of the front or rear side wall of the irradiation cassette 1 in order to perform the marking function.
It can be understood by those skilled in the art that, in the partitioned animal irradiation experimental apparatus, the distance between any two adjacent first grooves 8 is equal, and the distance between any two adjacent second grooves 9 on the same sidewall is equal.
It will be appreciated by those skilled in the art that the irradiation source may also be other point-like irradiation sources, e.g. 60 Co, and the like.
The irradiation experiment preparation process adopting the experimental device is as follows:
placing an irradiation box 1 at a proper position away from an irradiation source according to irradiation conditions such as radiation dose, dose rate, source distance and the like;
according to the volume of the irradiated animal, the partition boards 3 with proper quantity and adaptive height are inserted into the first groove 8 in the irradiation box 1 and are clamped with the second groove 9, so that a plurality of independent compartments are formed in the irradiation box 1;
the irradiation animals are sequentially placed into each compartment, the cover plate inlet and outlet 7 with the proper height is selected according to the body types of the irradiation animals, the cover plate 4 is inserted into the third groove 6 with the corresponding height, relatively closed compartments are formed, and after the irradiation animals are placed, the first protrusions 11 of the cover plate 4 are inserted into the grooves 10 with the heights corresponding to the cover plate inlet and outlet 7, so that a complete closed structure is formed. Then, animal irradiation experiments can be started.
In the partitioned animal irradiation experimental device, the irradiation box 1 is partitioned into a plurality of compartments by the first groove 8, the second groove 9 and the inserted partition plates 3, and a plurality of closed compartments are formed after the cover plate 4 is inserted.
Application example 1
As shown in fig. 7A and 7B, 2 rat partitions 3 are inserted inside the irradiation cassette 1 to form 3 compartments. Fig. 7A shows the cover plate 4 uncovered, and fig. 7B shows the cover plate 4 covered, when the cover plate 4 is inserted from the top cover plate access opening 7 to form a snap fit with the top third groove 6, so that the irradiation cassette 1 is closed.
Before the experiment begins, 1 rat is respectively placed into each compartment, 3 rats are placed into each compartment in total, and after the rats are placed, a cover plate 4 is covered to receive irradiation; after the experiment, promote apron 4 right, open irradiation box 1, take out irradiation rat and rat baffle 3, can wash whole device.
Wherein, the length of the irradiation box 1 (the length of the second bulge 2 is not counted) is 600mm, and the distance between two adjacent rat partition boards 3 is 200mm; the width (distance between two outer walls of the front and rear side walls) of the irradiation box 1 is 110mm, and the height of the irradiation box 1 is 100.5mm; the width of the cover plate 4 is 105mm; the height of the partition 3 is 75.5mm.
The radiation source used during the experiment is a point-like source, e.g. of radiation 137 Cs or 60 Co。
Application example 2
As shown in fig. 8, 11 mouse partitions 3 were inserted inside the irradiation cassette 1 to form 12 compartments. Before the experiment, 1 mouse is put into each compartment, and 12 mice are put into each compartment in total and are irradiated; after the experiment is finished, the cover plate 4 is pushed to the right, the irradiation box 1 is opened, and the irradiation mouse and the mouse partition plate 3 are taken out, so that the whole device can be cleaned.
The radiation source used during the experiment is a point-like source, e.g. of radiation 137 Cs or 60 Co。
In this example, the length of the irradiation cassette 1 (the length of the second projection 2 is not counted) is 600mm, and the distance between two adjacent partition plates 3 is 50mm; the width (distance between two outer walls of the front and rear side walls) of the irradiation box 1 is 110mm, and the height of the irradiation box 1 is 100.5mm; the width of the cover plate 4 is 105mm; the height of the mouse spacer 3 is 35mm.
It is clear that example 2 uses the same irradiation cassette 1 as example 1, differing only in the inserted spacers 3, including the height and number of spacers 3. Therefore, the partition type animal irradiation experimental device can realize the switching of the experimental device suitable for rats or mice by simply controlling the height and the number of the inserted partition plates 3, and is very convenient. Therefore, the partitioned animal irradiation experiment device can be compatible with the irradiation experiments of rats and mice and can also be compatible with the irradiation experiments of other experimental animals.
Therefore, in the partition type animal irradiation experimental device, the characteristics of the punctiform irradiation sources are fully considered, and the irradiation boxes capable of accommodating a plurality of experimental animals in the same group are arranged around the irradiation sources, so that the uniform irradiation dose which can be received by the animals in the same group can be ensured, and the accuracy and the reliability of the experimental results can be ensured; the irradiation box is divided into independent compartments with different quantities by the partition boards with adjustable quantity, and meanwhile, the height of the irradiation box is adjusted by the cover board with adjustable position, so that the compartments with different heights and lengths can be formed, and the irradiation box is suitable for irradiation experimental animals with different volumes and different body types, especially suitable for rats and mice. The device has fewer components, simple structure, low processing and manufacturing cost and very simple and convenient operation, adjustment or cleaning and maintenance.
It will thus be seen that the objects of the invention have been fully and effectively accomplished. The method and principles of the present invention have been shown and described in the examples, which can be modified in any way without departing from the principles. Therefore, this invention includes all modifications encompassed within the spirit and scope of the claims.
Claims (10)
1. An isolated animal irradiation experimental apparatus, comprising: an irradiation source and an irradiation box, wherein the irradiation source is a point-shaped irradiation source,
the irradiation box is a cuboid irradiation box and consists of a left end face, a right end face, a front side wall, a rear side wall and a bottom face, and the top face is open;
a plurality of horizontal cover plate inlets and outlets are arranged at different heights on the first end surface of the irradiation box;
a plurality of parallel first grooves are arranged on the inner bottom surface of the irradiation box at intervals, and the first grooves are parallel to the rectangular short edge of the bottom surface of the irradiation box;
a plurality of vertical second grooves are arranged on the inner walls of the front side wall and the rear side wall of the irradiation box at intervals, and the second grooves are vertical to the bottom surface of the irradiation box; the positions of the second grooves arranged on the front side wall and the rear side wall of the irradiation box are in one-to-one correspondence, and each group of one-to-one corresponding second grooves is vertically connected with one first groove;
a plurality of horizontal third grooves are arranged on the inner walls of the front side wall and the rear side wall of the irradiation box in parallel, and the positions of the third grooves arranged on the front side wall and the rear side wall of the irradiation box are in one-to-one correspondence; the height of each third groove in the vertical direction corresponds to the height of each cover plate inlet and outlet;
in addition, the block-type animal irradiation experimental device further comprises:
the partition plates are inserted into the first grooves and clamped with the second grooves on two sides, so that the irradiation box is divided into a plurality of compartments, and the compartments are used for accommodating experimental animals; and
the cover plate is used for being inserted into the third groove through the cover plate inlet and outlet to form clamping connection, so that the irradiation box is closed; the top surface of the cover plate is provided with a plurality of groups of vent holes.
2. The block type animal irradiation experiment device as claimed in claim 1, wherein the point radiation source is 137 Cs or 60 Co。
3. The block-type animal irradiation experimental facility as claimed in claim 1, wherein a plurality of horizontal grooves are provided at different heights on the second end face of the irradiation box, the number of the grooves is the same as that of the access ports of the cover plate, and the heights of the grooves are in one-to-one correspondence with those of the access ports of the cover plate; the first end of the cover plate is provided with a first bulge, and the first bulge is matched with the groove.
4. The partitioned animal irradiation experiment device as claimed in claim 1, wherein the distance between any two adjacent first grooves is equal, and the distance between any two adjacent second grooves on the same sidewall is equal.
5. The block-type animal irradiation experiment device as set forth in claim 1, wherein a second protrusion extending outward is provided on the second end surface of the irradiation cassette.
6. The block-type animal irradiation experiment device of claim 1, wherein the irradiation box, the partition plate and the cover plate are made of high transparent polypropylene materials.
7. The block-type animal irradiation experiment apparatus of claim 1, wherein the cover plate is a push-pull cover plate.
8. The block-type animal irradiation experiment apparatus of claim 1, wherein the vent holes of each set are evenly spaced on the top surface of the cover plate.
9. The block-type animal irradiation experiment apparatus of claim 8, wherein each set of the vent holes comprises 16 small vent holes and 1 large vent hole, and 16 of the small vent holes are radially distributed around the large vent hole.
10. The block-type animal irradiation experiment apparatus of claim 1, wherein the partition is provided with a mark.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110421440.4A CN115223743A (en) | 2021-04-20 | 2021-04-20 | Partition type animal irradiation experimental device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110421440.4A CN115223743A (en) | 2021-04-20 | 2021-04-20 | Partition type animal irradiation experimental device |
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| Publication Number | Publication Date |
|---|---|
| CN115223743A true CN115223743A (en) | 2022-10-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110421440.4A Pending CN115223743A (en) | 2021-04-20 | 2021-04-20 | Partition type animal irradiation experimental device |
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| Country | Link |
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| CN (1) | CN115223743A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115607860A (en) * | 2022-12-15 | 2023-01-17 | 首都医科大学宣武医院 | Device and method for establishing carotid artery stenosis mouse model after radiotherapy |
-
2021
- 2021-04-20 CN CN202110421440.4A patent/CN115223743A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115607860A (en) * | 2022-12-15 | 2023-01-17 | 首都医科大学宣武医院 | Device and method for establishing carotid artery stenosis mouse model after radiotherapy |
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