CN115212284A - Chinese medicinal compound for treating ischemic stroke and preparation method thereof - Google Patents

Chinese medicinal compound for treating ischemic stroke and preparation method thereof Download PDF

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Publication number
CN115212284A
CN115212284A CN202211002459.6A CN202211002459A CN115212284A CN 115212284 A CN115212284 A CN 115212284A CN 202211002459 A CN202211002459 A CN 202211002459A CN 115212284 A CN115212284 A CN 115212284A
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ischemic stroke
honey
ginger
weight
cassia twig
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郑光珊
黄龙坚
翟阳
王凯华
黄建民
李岩
覃启京
覃辉
陈莹
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International Zhuang Medical Hospital Of Guangxi
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International Zhuang Medical Hospital Of Guangxi
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Abstract

The invention discloses a traditional Chinese medicine compound for treating ischemic stroke in the technical field of traditional Chinese medicines, which comprises euonymus fortunei, cassia twig, rhizoma atractylodis, rhizoma pinellinae praeparata, poria cocos, fructus crataegi nandinae, pseudo-ginseng, pericarpium citri reticulatae, polygala fallax hemsl, cistanche, fructus cannabis, ginger and radix glycyrrhizae preparata; the compound takes the euonymus fortunei as a main drug, and has the effects of dredging the dragon's road, promoting blood circulation and enabling the medicines to directly reach the skilful dock; rhizoma atractylodis, tuckahoe and rhizoma pinellinae praeparata are taken as the common medicines, and the traditional Chinese medicine can promote diuresis, eliminate dampness and regulate spleen and stomach to regulate 'grain channel'; ramulus Cinnamomi, fructus crataegi and radix Polygalae Fallacis are used as mother medicines for communicating exterior and interior yin and yang, inducing pathogen to go out, supporting healthy qi, and regulating water channel; the dried orange peel is used as a medicine for promoting the circulation of qi and regulating the middle warmer; ginger and prepared licorice root, radix Glycyrrhizae Praeparata. The prescription takes the principal and subordinate symptoms into consideration, and the cassia twig, the ginger and the like which are used for opening the upper jiao are added with the poria cocos, the dried orange peel and the like which are used for opening the middle jiao to regulate the grain channel and the water channel, so that the dragon road fire is dredged, the two ways run normally, and the three ways are plugged, and the cerebral circulation and the nerve function of the patient with the ischemic stroke in the acute stage are improved.

Description

Chinese medicinal compound for treating ischemic stroke and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine compound for treating ischemic stroke and a preparation method thereof.
Background
Ischemic stroke refers to the biased development and conscious disturbance caused by cerebral infarction and cerebral artery obstruction on the basis of cerebral thrombosis or cerebral thrombosis, compared with hemorrhagic stroke, the ischemic stroke is slow in onset and often has premonitory symptoms, so that the 'golden time window' of treating ischemic stroke needs to be better maintained for 4.5 hours.
The therapeutic principle for ischemic stroke is to dissolve the thrombus as early as possible and to re-open the blood vessel. Conventional therapeutic approaches include western medicine treatments, such as tissue plasminogen activator (t-PA), an anticoagulant, but this drug carries the risk of intracranial hemorrhage; surgical treatment, such as neuro-intervention, by cutting a small opening at the perineum, introducing thrombolytic drugs into the blood vessel by means of a catheter with a large volume, and navigating the micro-catheter to the obstruction position in the brain by a micro-guide wire, but the method can be provided only by a comprehensive stroke treatment center, and the risk of missing gold treatment time exists for patients in the acute stage; traditional Chinese medicine treatment can take effect slowly although the root causes are treated, and is more suitable for the recovery period, so that when treating ischemic stroke, doctors often combine the traditional Chinese medicine and western medicine treatment means to treat patients with stroke, and in order to strive for longer treatment time for patients in the acute period, a traditional Chinese medicine compound for improving cerebral circulation and nerve functions of patients with ischemic stroke and a preparation method thereof are provided.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a traditional Chinese medicine compound for treating ischemic stroke and a preparation method thereof.
In order to achieve the purpose, the technical scheme of the invention is as follows: a Chinese medicinal compound for the treatment of ischemic apoplexy and its preparation method, its raw material medicine includes Euonymus fortunei 15-25g, ramulus Cinnamomi 10-20g, rhizoma Atractylodis 10-20g, rhizoma Pinelliae Preparata 15-25g, poria 10-20g, fructus crataegi 15-25g, notoginseng radix 10-20g, pericarpium Citri Tangerinae 10-20g, herba Polygalae Fallacis 10-20g, cistanchis herba 10-20g, fructus Cannabis 10-20g, rhizoma Zingiberis recens 10-20g, radix Glycyrrhizae Preparata 2-8g,
a Chinese medicinal composition for treating ischemic apoplexy and its preparation method: weighing euonymus fortunei by weight, decocting the euonymus fortunei in water for 3 times, extracting one third of euonymus fortunei in 1.5 hours for the first time, extracting one half of euonymus fortunei in 1 hour for the second time, extracting the rest of decoction in 0.5 hour for the third time, combining the decoctions, filtering, concentrating into clear paste, drying, and crushing to obtain first fine powder; weighing rhizoma atractylodis, rhizoma pinellinae praeparata and poria cocos according to parts by weight, mixing, putting into a vessel, drying and then crushing to obtain second fine powder; weighing cassia twig, south hawthorn and manyflower yellowflower water lily according to parts by weight, mixing, putting into a vessel, adding water, decocting, boiling with strong fire for 10-20 minutes, decocting with slow fire for 60 minutes, filtering, concentrating into clear paste, drying, and crushing to obtain third fine powder; weighing dried orange peel, cistanche, fructus cannabis, ginger, honey-fried licorice root and pseudo-ginseng according to the weight parts, respectively crushing, pouring all fine powder into a vessel, and uniformly stirring for later use; adding the honey with the same weight as the medicinal powder into a pot, slowly heating with slow fire until boiling to obtain small and dense bubbles, pouring the honey into the medicinal powder when the bubbles are large, stirring with chopsticks, and kneading the large block masses with hands when the small block masses are small to ensure the hardness of the medicinal powder to be consistent, and uniformly cooling the medicinal powder and honey to obtain the Chinese medicinal pills with consistent size.
After the scheme is adopted, the following beneficial effects are realized:
wintercreeper: has tranquilizing, analgesic, anticoagulant, qi and blood invigorating, liver and kidney nourishing, muscles and tendons relaxing, collateral flow activating, hemostatic, and blood stasis removing effects.
Rhizoma atractylodis: has effects of dredging meridian passage, and can be used for resisting thrombi, promoting hematopoiesis, relieving swelling and pain.
Rhizoma pinelliae preparata: eliminating dampness and phlegm, lowering adverse qi and relieving vomit, relieving oppression and resolving masses, and improving cardiovascular function, and can be used for treating damp phlegm cough, wind phlegm giddiness, phlegm syncope headache, emesis and regurgitation, chest and gastric cavity stuffiness and distress, globus hystericus, goiter tumor, subcutaneous nodule, superficial infection and pyogenic infections.
Tuckahoe, poria cocos: has effects of removing toxic substance, eliminating dampness, and relieving arthralgia, and is mainly used for relieving rigidity of muscles and activating collaterals.
Cassia twig: has effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels and collaterals, supporting yang, regulating qi, and calming the adverse-rising energy, and can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold, amenorrhea, arthralgia, phlegm retention, edema, and palpitation.
South hawthorn: has effects of resolving food stagnation, removing qi stagnation, removing blood stasis, lowering blood pressure, increasing coronary blood flow, and reducing blood lipid for cardiovascular system.
Radix Polygalae Fallacis: has the effects of tonifying, strengthening, eliminating dampness and removing blood stasis, and is mainly used for relaxing muscles and tendons, activating collaterals, and treating jaundice and irregular menstruation.
Dried orange peel: has the effects of regulating qi, strengthening spleen, eliminating dampness and phlegm, and can be used for treating spleen and stomach qi stagnation syndrome and phlegm-damp stagnation syndrome.
Cistanche deserticola: has the effects of invigorating kidney yang, replenishing essence and blood, and loosening bowel to relieve constipation, and can be used for: impotence, infertility, soreness and weakness of the waist and knees, weakness of the bones and muscles, constipation due to intestinal dryness.
Fructus cannabis: moistening dryness, relaxing bowels, tonifying deficiency, promoting myocardial contraction, improving oxygen uptake of myocardial cells, and promoting blood circulation.
Ginger: has effects in promoting blood circulation, dispelling cold, eliminating dampness, promoting perspiration, invigorating stomach, relieving vomit, eliminating fishy smell, and eliminating edema.
Honey-fried licorice root: tonify spleen and stomach, benefit qi and recover pulse. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, and intermittent pulse, and can relieve subsidiary toxicity.
Pseudo-ginseng: has the effects of removing blood stasis, stopping bleeding, relieving swelling and relieving pain, and is mainly used for resisting thrombus, promoting hematopoiesis, relieving swelling and relieving pain, and the like.
The drug effect of the euonymus fortunei can be fully exerted by decocting the euonymus fortunei for three times and respectively extracting decoction liquid, and the euonymus fortunei is taken as a main drug to promote the circulation of blood and lead the medicine to directly reach the skilful dock; rhizoma atractylodis, tuckahoe and rhizoma pinellinae praeparata are used as the common medicines for promoting diuresis and eliminating dampness and regulating the function of the spleen and stomach to dredge the 'valley way'; ramulus Cinnamomi, fructus crataegi and radix Polygalae Fallacis are used as mother medicines for communicating exterior and interior yin and yang, inducing pathogen to go out, supporting healthy qi, and regulating water channel; the dried orange peel is used as a medicine for promoting the circulation of qi and regulating the middle warmer; ginger and prepared licorice root, radix Glycyrrhizae Praeparata. The prescription gives consideration to both symptoms and root causes, and cassia twig, ginger and the like which are used for opening the upper jiao are added with tuckahoe, dried orange peel and the like which are used for opening the middle jiao to regulate the grain passage and the water passage, so that the Longlu fire is dredged, two ways are normally operated, and three ways are unblocked, and the cerebral circulation and the nerve function of a patient with ischemic stroke in the acute stage are improved.
Detailed Description
The following is a more detailed description of the present invention by way of specific embodiments.
The specific implementation process is as follows:
example one
A traditional Chinese medicine compound for treating ischemic stroke comprises, by weight, 15-25g of euonymus fortunei, 10-20g of cassia twig, 10-20g of rhizoma atractylodis, 15-25g of rhizoma pinellinae praeparata, 10-20g of poria cocos, 15-25g of hawthorn, 10-20g of pseudo-ginseng, 10-20g of pericarpium citri reticulatae, 10-20g of polygala fallax hemsl, 10-20g of cistanche deserticola, 10-20g of fructus cannabis, 10-20g of ginger and 2-8g of honey-fried licorice root.
Example two
A traditional Chinese medicine compound for treating ischemic stroke comprises the following raw materials in parts by weight: 15g of euonymus fortunei, 10g of cassia twig, 10g of rhizoma atractylodis, 15g of rhizoma pinellinae praeparata, 10g of poria cocos, 15g of fructus crataegi cuneatae, 10g of pseudo-ginseng, 10g of dried orange peel, 10g of radix polygalae fallax, 10g of cistanche, 10g of fructus cannabis, 10g of ginger and 2g of honey-fried licorice root
EXAMPLE III
A traditional Chinese medicine compound for treating ischemic stroke comprises the following raw materials in parts by weight: 20g of euonymus fortunei, 15g of cassia twig, 15g of rhizoma atractylodis, 20g of rhizoma pinellinae praeparata, 15g of poria cocos, 20g of fructus crataegi cuneatae, 15g of pseudo-ginseng, 15g of pericarpium citri reticulatae, 15g of radix polygalae fallax, 15g of cistanche, 15g of fructus cannabis, 15g of ginger and 5g of honey-fried licorice root
Example four
A traditional Chinese medicine compound for treating ischemic stroke comprises the following raw materials in parts by weight: 25g of euonymus fortunei, 20g of cassia twig, 20g of rhizoma atractylodis, 25g of rhizoma pinellinae praeparata, 20g of poria cocos, 25g of fructus crataegi cuneatae, 20g of pseudo-ginseng, 20g of pericarpium citri reticulatae, 20g of radix polygalae fallax, 20g of cistanche, 20g of fructus cannabis, 20g of ginger and 8g of honey-fried licorice root
EXAMPLE five
A Chinese medicinal compound for the treatment of ischemic apoplexy and its preparation method, including the following step, weigh Euonymus fortunei according to the part by weight, euonymus fortunei is decocted in water for 3 times, extract one third in decocting 1.5 hours for the first time, extract one half after decocting 1 hour for the second time, extract the remaining decoction after decocting 0.5 hours for the third time, mix the decoction, filter, concentrate into supernate, oven dry, pulverize, get the first furfurescence; weighing rhizoma atractylodis, rhizoma pinellinae praeparata and poria cocos according to parts by weight, mixing, putting into a vessel, drying and then crushing to obtain second fine powder; weighing cassia twig, south hawthorn and manyflower lilac flower in parts by weight, mixing, putting into a vessel, adding water, decocting, boiling with strong fire for 10-20 minutes, decocting with slow fire for 60 minutes, filtering, concentrating into clear paste, drying and crushing to obtain third fine powder; weighing dried orange peel, cistanche, fructus cannabis, ginger, honey-fried licorice root and pseudo-ginseng according to the weight parts, respectively crushing, pouring all fine powder into a vessel, and uniformly stirring for later use; the honey with the same weight as the medicinal powder is taken and put into a pot, the pot is slowly heated by small fire until the honey is boiled to generate small and dense bubbles, when the small bubbles are changed into big bubbles, the honey is poured into the medicinal powder while the honey is hot, the chopsticks are used for stirring continuously, when the big block masses are reduced, the honey can be kneaded by hand, all the medicinal powder is blended together, the hardness of the medicinal powder is ensured to be consistent, and after the medicinal powder and the honey are uniform, the medicinal powder and the honey are not cooled and are evenly divided into Chinese medicine pills with the same size as soon as possible. The weight parts of the raw materials in the examples are selected according to any one of the first to fourth examples.
In the above medicament, wherein:
wintercreeper: has tranquilizing, analgesic, and anticoagulant effects, and can be used for invigorating qi and blood, nourishing liver and kidney, relaxing muscles and tendons, activating collateral flow, stopping bleeding, and dispelling blood stasis.
And (5) rhizoma atractylodis: has effects of dredging meridian passage, and can be used for resisting thrombi, promoting hematopoiesis, relieving swelling and pain.
Rhizoma pinelliae preparata: eliminating dampness and phlegm, lowering adverse qi and relieving vomit, relieving oppression and resolving masses, and improving cardiovascular function, and can be used for treating damp phlegm cough, wind phlegm giddiness, phlegm syncope headache, emesis and regurgitation, chest and gastric cavity stuffiness and distress, globus hystericus, goiter tumor, subcutaneous nodule, superficial infection and pyogenic infections.
Tuckahoe, poria cocos: has effects of removing toxic substance, eliminating dampness, and relieving arthralgia, and is mainly used for relieving rigidity of muscles and activating collaterals.
Cassia twig: has effects of inducing sweat, expelling pathogenic factors from muscles, warming and activating channels, supporting yang, regulating qi-flowing, and calming the adverse-rising energy, and can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold type amenorrhea, arthralgia, phlegm and fluid retention, edema, and palpitation.
South hawthorn: has effects of resolving food stagnation, removing qi stagnation, dispelling blood stasis, lowering blood pressure, increasing coronary blood flow, and reducing blood lipid for cardiovascular system.
Radix Polygalae Fallacis: has the effects of tonifying, strengthening, eliminating dampness and removing blood stasis, and is mainly used for relaxing muscles and tendons, activating collaterals, and treating jaundice and irregular menstruation.
Dried orange peel: has the effects of regulating qi, strengthening spleen, eliminating dampness and phlegm, and can be used for treating spleen and stomach qi stagnation syndrome and phlegm-damp stagnation syndrome.
Cistanche deserticola: has the effects of invigorating kidney yang, nourishing essence and blood, and loosening bowel to relieve constipation, and can be used for: impotence, infertility, soreness and weakness of the loins and knees, weakness of tendons and bones, constipation due to intestinal dryness.
Fructus cannabis: moistening dryness, relaxing bowels, tonifying deficiency, promoting myocardial contraction, improving oxygen uptake of myocardial cells, and promoting blood circulation.
Ginger: has effects in promoting blood circulation, dispelling cold, eliminating dampness, promoting perspiration, invigorating stomach, relieving vomit, expelling fishy smell, and eliminating edema.
Honey-fried licorice root: tonify spleen and stomach, replenish qi and recover pulse. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, and intermittent pulse, and can relieve subsidiary toxicity.
Pseudo-ginseng: has the effects of removing blood stasis, stopping bleeding, relieving swelling and relieving pain, and is mainly used for resisting thrombus, promoting hematopoiesis, relieving swelling and relieving pain, and the like.
The medicine is prepared from 13 medicines of euonymus fortunei, cassia twig, rhizoma atractylodis and the like according to the matching principle of strong prescription. In the formula, euonymus fortunei is used as a main drug, and is used for dredging the dragon road and promoting blood circulation, so that the medicine can directly reach the skilful dock; rhizoma atractylodis, tuckahoe and rhizoma pinellinae praeparata are taken as the common medicines, and the traditional Chinese medicine can promote diuresis, eliminate dampness and regulate spleen and stomach to regulate 'grain channel'; ramulus Cinnamomi, fructus crataegi and radix Polygalae Fallacis are used as mother medicines for communicating exterior and interior yin and yang, inducing pathogen to go out, supporting healthy qi, and regulating water channel; the dried orange peel is used as an assistant drug to promote the circulation of qi and harmonize the middle; ginger and prepared licorice root, radix Glycyrrhizae Praeparata. The prescription gives consideration to both symptoms and root causes, and cassia twig, ginger and the like which are used for opening the upper jiao are added with tuckahoe, dried orange peel and the like which are used for opening the middle jiao to regulate the grain passage and the water passage, so that the Longlu fire is dredged, two ways are normally operated, and three ways are unblocked, and the cerebral circulation and the nerve function of a patient with ischemic stroke in the acute stage are improved.
The product of the invention is a traditional Chinese medicine pill, is more convenient for patients to carry, can be taken orally immediately when suffering from ischemic stroke, can strive for more time for hospital treatment, and patients in convalescent period can also take the medicine to continuously improve cerebral circulation and nerve functions.
Clinical experiments show that the method has good beneficial technical effects, and the relevant experimental data are as follows:
1. general data
1.1 case origin: the cases were from: 32 outpatients, 68 wards, 100 cases, wherein 72 men and 28 women are in 28 cases, the age is 35-70 years, and the average age is 50 years; the course of the disease is more than 2 hours and within 30 days.
1.2 case selection
1.2.1 Western diagnostic criteria: refer to the fourth revised diagnostic principle of cerebrovascular diseases of the third national academy of cerebrovascular diseases of the Chinese medical society in 1995. All cases met the following conditions: frequently, the disease occurs in a quiet state. Most of the cases were without significant headache and vomiting. The onset of the disease is slow, gradual or stage, and is usually related to cerebral atherosclerosis, such as arteritis and blood diseases. Clear consciousness or mild disturbance within 1-2 days after the onset of the disease. There are symptoms and signs of the internal carotid and/or basilar arterial systems. A cranial CT or MRI examination should be performed. Cerebrospinal fluid for lumbar puncture should generally not contain blood.
1.2.2 Chinese medicine diagnosis standard: the main symptoms are: hemiplegia, coma, slurred speech or aphasia, abnormal sensation of the body and tongue. The secondary symptoms are as follows: restlessness, insomnia, soreness and weakness of the loins and knees, vertigo, tinnitus, spasm or peristalsis of the hands and feet, dark tongue with thin and small coating, and wiry, thready or deep and thready pulse. Acute onset usually has a predisposing cause before onset, and a premonitory symptom is usually observed. The onset age is usually 40 years or older. The diagnosis can be confirmed by combining the onset, the cause, the premonitory symptoms and the age, wherein the number of the main symptoms is more than 2, or 1 main symptom and 2 secondary symptoms; without the above conditions, the diagnosis can be confirmed by combining the results of the imaging examination.
2. The treatment method comprises the following steps: the traditional Chinese medicine pill for treating ischemic stroke is taken three weeks, 3 pills each time and three times a day, and can be taken by patients in acute stage when the patients suffer from the diseases.
3. And (3) observation indexes are as follows: hemorheology
4. Statistical treatment
TABLE 4-1 comparison of index changes (x. + -. S) of the haemorheology before and after treatment
Before taking After taking
Whole blood high shear viscosity (mPa. S) 5.97±0.42 5.16±0.11*
Whole blood Low cut viscosity (mPa. S) 9.13±1.62 6.97±1.42*
Specific viscosity of plasma (mPa. S) 3.97±1.32 1.87±0.92**
Fibrinogen (g/L) 4.51±0.47 2.97±0.79*
Packed cell volume (%) 45.97±5.42 37.15±3.77*
Note: * Represents P < 0.05 compared with the medicine before taking
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered as the technical solutions and the inventive concepts of the present invention within the technical scope of the present invention.
5. Conclusion
Clinical results show that the invention can improve the blood circulation and the nerve function of the brain of a patient, and reduce various blood flow indexes such as whole blood specific viscosity, plasma specific viscosity, hematocrit, fibrinogen and the like. The Chinese medicine compound is prepared from 13 medicines such as euonymus fortunei, cassia twig, rhizoma atractylodis and the like, can resist thrombus, eliminate stasis and relieve pain, and the euonymus fortunei is used as a main medicine, is used for dredging the dragon road and activating blood, and leads the medicines to directly reach the skilful dock; rhizoma atractylodis, tuckahoe and rhizoma pinellinae praeparata are taken as the common medicines, and the traditional Chinese medicine can promote diuresis, eliminate dampness and regulate spleen and stomach to regulate 'grain channel'; ramulus Cinnamomi, fructus crataegi, and radix Polygalae Fallacis as mother medicines for communicating yin and yang, inducing pathogen to go out, supporting vital qi, and regulating water channel; the dried orange peel is used as an assistant drug to promote the circulation of qi and harmonize the middle; ginger and prepared licorice root, radix Glycyrrhizae Praeparata. The prescription gives consideration to both principal and secondary aspects, and cassia twig, ginger and the like which are opened to the upper part of the body are added with poria cocos, dried orange peel and the like which are opened to the middle part of the body to regulate the grain passage and the water passage, so that the dragon road fire is dredged, two ways of medicines run normally, and three ways of medicines are plugged.
The foregoing is merely an example of the present invention and common general knowledge in the art of specific structures and/or features of the invention has not been set forth herein in any way. It should be noted that, for those skilled in the art, without departing from the structure of the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.

Claims (7)

1. A traditional Chinese medicine compound for treating ischemic stroke is characterized by comprising the following raw materials in parts by weight: 15-25g of euonymus fortunei, 10-20g of cassia twig, 10-20g of rhizoma atractylodis, 15-25g of rhizoma pinellinae praeparata, 10-20g of poria cocos, 15-25g of fructus crataegi cuneatae, 10-20g of pseudo-ginseng, 10-20g of dried orange peel, 10-20g of polygala fallax hemsl, 10-20g of cistanche, 10-20g of fructus cannabis, 10-20g of ginger and 2-8g of honey-fried licorice root.
2. The traditional Chinese medicine compound for treating ischemic stroke according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 15g of euonymus fortunei, 10g of cassia twig, 10g of rhizoma atractylodis, 15g of rhizoma pinellinae praeparata, 10g of poria cocos, 15g of fructus crataegi cuneatae, 10g of pseudo-ginseng, 10g of pericarpium citri reticulatae, 10g of radix polygalae fallax, 10g of cistanche, 10g of fructus cannabis, 10g of ginger and 2g of honey-fried licorice root.
3. The traditional Chinese medicine compound for treating ischemic stroke according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 20g of euonymus fortunei, 15g of cassia twig, 15g of rhizoma atractylodis, 20g of rhizoma pinellinae praeparata, 15g of poria cocos, 20g of fructus crataegi cuneatae, 15g of pseudo-ginseng, 15g of pericarpium citri reticulatae, 15g of radix polygalae fallax, 15g of cistanche, 15g of fructus cannabis, 15g of ginger and 5g of honey-fried licorice root.
4. The traditional Chinese medicine compound for treating ischemic stroke according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 25g of euonymus fortunei, 20g of cassia twig, 20g of rhizoma atractylodis, 25g of rhizoma pinellinae praeparata, 20g of poria cocos, 25g of fructus crataegi cuneatae, 20g of pseudo-ginseng, 20g of pericarpium citri reticulatae, 20g of polygala fallax hemsl, 20g of cistanche, 20g of fructus cannabis, 20g of ginger and 8g of honey-fried licorice root.
5. The method for preparing a Chinese herbal compound for treating ischemic stroke according to any one of claims 1 to 4, characterized in that the wintercreeper is weighed according to the parts by weight, the wintercreeper is decocted in water for 3 times, the decoction is merged, filtered, concentrated into clear paste, dried and crushed to obtain first fine powder; weighing rhizoma atractylodis, rhizoma pinellinae praeparata and poria cocos according to the parts by weight, mixing, putting into a vessel, drying and then crushing to obtain second fine powder; weighing cassia twig, south hawthorn and manyflower lilac flower in parts by weight, mixing, putting into a vessel, adding water, decocting for 1 time, filtering, concentrating into clear paste, drying and crushing to obtain third fine powder; weighing dried orange peel, cistanche, fructus cannabis, ginger, honey-fried licorice root and pseudo-ginseng according to the weight parts, respectively crushing, pouring all fine powder into a vessel, and uniformly stirring for later use; adding the honey with the same weight as the medicinal powder into a pot, slowly heating with slow fire until boiling to obtain small and dense bubbles, pouring the honey into the medicinal powder when the bubbles are large, stirring with chopsticks, and kneading the large block masses with hands when the small block masses are small to ensure the hardness of the medicinal powder to be consistent, and uniformly cooling the medicinal powder and honey to obtain the Chinese medicinal pills with consistent size.
6. The method for preparing a Chinese herbal compound prescription for treating ischemic stroke according to claim 5, characterized in that the euonymus fortunei is decocted with slow fire for three times by adding water, one third of the euonymus fortunei is extracted after 1.5 hours of decoction for the first time, one half of the euonymus fortunei is extracted after 1 hour of continuous decoction for the second time, and the rest of decoction is extracted after 0.5 hour of continuous decoction for the third time.
7. The method for preparing a compound Chinese medicine for treating ischemic stroke as claimed in claim 5, wherein the cassia twig, the south hawthorn fruit and the radix astragali Sinici are boiled with strong fire for 10-20 minutes and then decocted with slow fire for 60 minutes when they are mixed and decocted.
CN202211002459.6A 2022-08-22 2022-08-22 Chinese medicinal compound for treating ischemic stroke and preparation method thereof Pending CN115212284A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116392540A (en) * 2023-03-14 2023-07-07 广西国际壮医医院 Jinxiangxueyu vine drink for relieving stroke depression and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106729580A (en) * 2017-02-14 2017-05-31 广西中医药大学第附属医院 Treat the Chinese medicine of apoplexy at acute stage
CN111671884A (en) * 2020-07-24 2020-09-18 广西国际壮医医院 Pharmaceutical composition for treating cerebral apoplexy and depression caused by cerebral apoplexy and production method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106729580A (en) * 2017-02-14 2017-05-31 广西中医药大学第附属医院 Treat the Chinese medicine of apoplexy at acute stage
CN111671884A (en) * 2020-07-24 2020-09-18 广西国际壮医医院 Pharmaceutical composition for treating cerebral apoplexy and depression caused by cerebral apoplexy and production method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
陈晓锋,等: "壮通饮治疗恢复期脑梗死60例临床观察" *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116392540A (en) * 2023-03-14 2023-07-07 广西国际壮医医院 Jinxiangxueyu vine drink for relieving stroke depression and preparation method thereof
CN116392540B (en) * 2023-03-14 2024-01-30 广西国际壮医医院 Jinxiangxueyu vine drink for relieving stroke depression and preparation method thereof

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Application publication date: 20221021