CN115193243A - Self-balancing oxygen inhalation composition for medicine bagging, and preparation device and preparation method thereof - Google Patents
Self-balancing oxygen inhalation composition for medicine bagging, and preparation device and preparation method thereof Download PDFInfo
- Publication number
- CN115193243A CN115193243A CN202210564313.4A CN202210564313A CN115193243A CN 115193243 A CN115193243 A CN 115193243A CN 202210564313 A CN202210564313 A CN 202210564313A CN 115193243 A CN115193243 A CN 115193243A
- Authority
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- China
- Prior art keywords
- blanking
- oxygen
- pipe
- film
- self
- Prior art date
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Links
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 183
- 239000001301 oxygen Substances 0.000 title claims abstract description 183
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 183
- 239000000203 mixture Substances 0.000 title claims abstract description 132
- 239000003814 drug Substances 0.000 title claims abstract description 79
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 238000010521 absorption reaction Methods 0.000 claims abstract description 47
- 238000004806 packaging method and process Methods 0.000 claims abstract description 37
- 239000003638 chemical reducing agent Substances 0.000 claims abstract description 36
- 229940079593 drug Drugs 0.000 claims abstract description 30
- 239000002250 absorbent Substances 0.000 claims abstract description 24
- 230000002745 absorbent Effects 0.000 claims abstract description 24
- 239000003054 catalyst Substances 0.000 claims abstract description 15
- 239000003463 adsorbent Substances 0.000 claims abstract description 14
- 239000003085 diluting agent Substances 0.000 claims abstract description 11
- 239000000945 filler Substances 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims description 71
- 230000007246 mechanism Effects 0.000 claims description 28
- 229920006280 packaging film Polymers 0.000 claims description 27
- 239000012785 packaging film Substances 0.000 claims description 27
- 238000002156 mixing Methods 0.000 claims description 22
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 19
- 230000005540 biological transmission Effects 0.000 claims description 17
- 238000006243 chemical reaction Methods 0.000 claims description 13
- 238000010438 heat treatment Methods 0.000 claims description 13
- 230000009471 action Effects 0.000 claims description 12
- 238000000465 moulding Methods 0.000 claims description 12
- -1 polypropylene Polymers 0.000 claims description 12
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 11
- 230000001360 synchronised effect Effects 0.000 claims description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 10
- 239000004743 Polypropylene Substances 0.000 claims description 8
- 229920000690 Tyvek Polymers 0.000 claims description 8
- 239000004775 Tyvek Substances 0.000 claims description 8
- 230000000712 assembly Effects 0.000 claims description 8
- 238000000429 assembly Methods 0.000 claims description 8
- 229920001155 polypropylene Polymers 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 8
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 6
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 6
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 6
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 6
- 239000000440 bentonite Substances 0.000 claims description 5
- 229910000278 bentonite Inorganic materials 0.000 claims description 5
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 5
- 230000009467 reduction Effects 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 235000010265 sodium sulphite Nutrition 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 229910052742 iron Inorganic materials 0.000 claims description 4
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 claims description 4
- 239000011592 zinc chloride Substances 0.000 claims description 4
- 235000005074 zinc chloride Nutrition 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- 229910021578 Iron(III) chloride Inorganic materials 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 229910001567 cementite Inorganic materials 0.000 claims description 3
- 239000011790 ferrous sulphate Substances 0.000 claims description 3
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 3
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims description 3
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 3
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 3
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 3
- 229910021332 silicide Inorganic materials 0.000 claims description 3
- FVBUAEGBCNSCDD-UHFFFAOYSA-N silicide(4-) Chemical compound [Si-4] FVBUAEGBCNSCDD-UHFFFAOYSA-N 0.000 claims description 3
- 235000010352 sodium erythorbate Nutrition 0.000 claims description 3
- 239000004320 sodium erythorbate Substances 0.000 claims description 3
- RBWSWDPRDBEWCR-RKJRWTFHSA-N sodium;(2r)-2-[(2r)-3,4-dihydroxy-5-oxo-2h-furan-2-yl]-2-hydroxyethanolate Chemical compound [Na+].[O-]C[C@@H](O)[C@H]1OC(=O)C(O)=C1O RBWSWDPRDBEWCR-RKJRWTFHSA-N 0.000 claims description 3
- 238000000748 compression moulding Methods 0.000 claims description 2
- 230000033444 hydroxylation Effects 0.000 claims 1
- 238000005805 hydroxylation reaction Methods 0.000 claims 1
- 238000003860 storage Methods 0.000 abstract description 8
- 239000006096 absorbing agent Substances 0.000 abstract description 7
- 230000007547 defect Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 9
- 230000001276 controlling effect Effects 0.000 description 8
- 238000007254 oxidation reaction Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000003213 activating effect Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 230000003647 oxidation Effects 0.000 description 7
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000033001 locomotion Effects 0.000 description 5
- 239000000825 pharmaceutical preparation Substances 0.000 description 5
- 229940127557 pharmaceutical product Drugs 0.000 description 5
- 239000000377 silicon dioxide Substances 0.000 description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 239000004519 grease Substances 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 239000004952 Polyamide Substances 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 3
- 239000000920 calcium hydroxide Substances 0.000 description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 3
- 239000004927 clay Substances 0.000 description 3
- 230000006866 deterioration Effects 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229920002647 polyamide Polymers 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- 229910052902 vermiculite Inorganic materials 0.000 description 3
- 239000010455 vermiculite Substances 0.000 description 3
- 235000019354 vermiculite Nutrition 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 2
- 229910021536 Zeolite Inorganic materials 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 239000000378 calcium silicate Substances 0.000 description 2
- 229910052918 calcium silicate Inorganic materials 0.000 description 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 150000002085 enols Chemical class 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 238000010525 oxidative degradation reaction Methods 0.000 description 2
- 238000012858 packaging process Methods 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical compound O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 239000010457 zeolite Substances 0.000 description 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- AGIJRRREJXSQJR-UHFFFAOYSA-N 2h-thiazine Chemical compound N1SC=CC=C1 AGIJRRREJXSQJR-UHFFFAOYSA-N 0.000 description 1
- AKUVRZKNLXYTJX-UHFFFAOYSA-N 3-benzylazetidine Chemical compound C=1C=CC=CC=1CC1CNC1 AKUVRZKNLXYTJX-UHFFFAOYSA-N 0.000 description 1
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 235000001258 Cinchona calisaya Nutrition 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 229960000212 aminophenazone Drugs 0.000 description 1
- 229940113720 aminosalicylate Drugs 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 150000004982 aromatic amines Chemical class 0.000 description 1
- 238000006701 autoxidation reaction Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960001701 chloroform Drugs 0.000 description 1
- 229960003677 chloroquine Drugs 0.000 description 1
- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 description 1
- 229960001657 chlorpromazine hydrochloride Drugs 0.000 description 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 229960004132 diethyl ether Drugs 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 125000002587 enol group Chemical group 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000011874 heated mixture Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 235000014413 iron hydroxide Nutrition 0.000 description 1
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- DJGAAPFSPWAYTJ-UHFFFAOYSA-M metamizole sodium Chemical compound [Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 DJGAAPFSPWAYTJ-UHFFFAOYSA-M 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000006864 oxidative decomposition reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- XXPDBLUZJRXNNZ-UHFFFAOYSA-N promethazine hydrochloride Chemical compound Cl.C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 XXPDBLUZJRXNNZ-UHFFFAOYSA-N 0.000 description 1
- 229960002244 promethazine hydrochloride Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229960000948 quinine Drugs 0.000 description 1
- 150000004053 quinones Chemical class 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- CGRKCGWEOIQFRD-UHFFFAOYSA-N sodium;(4-aminophenyl)sulfonylazanide Chemical class [Na+].NC1=CC=C(S([NH-])(=O)=O)C=C1 CGRKCGWEOIQFRD-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229940126589 solid medicine Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/34—Chemical or biological purification of waste gases
- B01D53/74—General processes for purification of waste gases; Apparatus or devices specially adapted therefor
- B01D53/81—Solid phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/34—Chemical or biological purification of waste gases
- B01D53/74—General processes for purification of waste gases; Apparatus or devices specially adapted therefor
- B01D53/86—Catalytic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2257/00—Components to be removed
- B01D2257/10—Single element gases other than halogens
- B01D2257/104—Oxygen
Landscapes
- Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a self-balancing oxygen absorption composition for medicine bagging, a preparation device and a preparation method thereof, and belongs to the technical field of medicine bagged oxygen absorbers. The self-balancing oxygen absorption composition for the medicine bag comprises the following components in percentage by mass: 40-60% of reducing agent, 0.1-0.5% of catalyst, 1-10% of humidity regulator, 0.1-0.5% of acid-base regulator, 0.5-4% of adsorbent, 4-15% of diluent and 10-30% of filler. The oxygen absorption composition prepared by the invention is applied to oxygen absorption in medicine bags, so that the oxygen concentration in the medicine bags is reduced to be below 0.1%, the storage humidity of medicines in the packaging bags is controlled within a proper range, the relative humidity is automatically balanced to the proper storage humidity for oral administration, and the defect that the humidity of a conventional oxygen absorbent is increased during oxygen absorption is overcome.
Description
Technical Field
The invention belongs to the technical field of medicine bag oxygen absorbents, and particularly relates to a self-balancing oxygen absorption composition for medicine bag packaging, and a preparation device and a preparation method thereof.
Background
The medicine is easy to generate oxidation reaction with oxygen to generate peroxide compounds, so that the medicine is deteriorated, and particularly, the reaction of the oxygen and the medicine can be accelerated under the catalysis of moist air and light. Some solid drugs are exposed in humid air and are easily oxidized by oxygen; the air remained on the upper part of the preparation tank of the liquid medicine and the ampoule of the liquid medicine, the oxygen dissolved in the liquid medicine and the water for injection can all cause the oxidation of the medicine with strong reducibility. Oxidative decomposition of the drug can lead to drug failure, darken the color, or form precipitates or produce toxic substances (such as neoarsine which is exposed to air and is easily oxidized and deteriorated, and the toxicity is obviously increased, so that the drug cannot be used for medicine). Some injections have a very small oxidation of the drug, but a darker color, which may be a waste product.
The medicinal preparation is subjected to the oxidation of oxygen in the air at normal temperature to generate a degradation reaction, namely an autoxidation reaction. As a result of the oxidative degradation, not only the drug effect is lowered, but also color change or precipitation may occur, resulting in unsatisfactory clarity and even generation of toxic substances. For example, phenolic drugs such as epinephrine, dopamine, morphine, sodium salicylate, etc. are all easily oxidized and deteriorated under the influence of oxygen, metal ions, light, temperature, etc., and some quinone compounds with colors are formed after oxidation, for example, phenol is changed into rose red; the oxidation of enol drugs is represented by vitamin C, and molecules of the enol drugs contain two enol groups which are very easy to oxidize and are easy to oxidize under aerobic and anaerobic conditions; oxidation of arylamine drugs such as sulfanilamide sodium salt, para-aminosalicylate and the like is easy to oxidize and discolor; oxidation of other types of drugs: pyrazolone drugs such as aminopyrine, analgin, etc., are easily oxidized due to unsaturated bonds on the pyrazolone ring; thiazine drugs such as promethazine hydrochloride, chlorpromazine hydrochloride and the like are easily oxidized and discolored under the influence of moisture, light, metal ions, oxygen and the like; unsaturated bond-containing drugs such as oil and fat, vitamin A and the like are also very easy to oxidize and often accompanied by special smells. In addition, quinine, chloroquine, chloroform, diethyl ether, etc. are susceptible to oxidative degradation. Some bagged medicines are inevitably subjected to oxygen remaining in the packaging tape, which causes a great risk. In order to prevent oxidative deterioration of drugs, antioxidants can be used, and the use of deoxidizers is a very effective and safe method and has been widely used in medicine. The conventional oxygen absorbent is applied to medicines in Japan and European countries, but the conventional oxygen absorbent generates water vapor during oxygen absorption reaction, so that the humidity of the medicine storage environment is increased. And if the humidity of the medicine storage environment is too high, the medicine is easy to absorb moisture, so that the phenomena of deliquescence, denaturation, agglomeration and the like are caused, and the medicine can also generate the risk of deterioration.
Disclosure of Invention
The invention aims to: in order to solve the problems, the invention provides a self-balancing oxygen absorption composition for medicine bagging and a preparation method of a bagged oxygen absorbent.
The technical scheme is as follows: a self-balancing oxygen absorption composition (hereinafter referred to as oxygen absorption composition) for medicine packaging comprises the following components in percentage by mass:
40-60% of reducing agent
0.1 to 0.5 percent of catalyst
1-10% of humidity regulator
0.1-0.5% of acid-base regulator
0.5% -4% of adsorbent
4 to 15 percent of diluent
10-30% of filler.
Preferably, the reducing agent is one or a combination of several of reduced iron powder, copper powder, aluminum powder, zinc powder, iron carbide, iron hydroxide, iron silicide, ferrous sulfate, sodium sulfite, sodium erythorbate, or sodium sulfite.
Preferably, the catalyst is one of potassium bromide, sodium chloride, zinc chloride or ferric chloride.
Preferably, the humidity regulator is one or a combination of more of montmorillonite, calcium chloride, silica gel, alumina, bentonite or magnesium chloride.
Preferably, the pH regulator is one of sodium hydroxide, sodium carbonate, calcium hydroxide or sodium bicarbonate.
Preferably, the adsorbent is activated carbon or montmorillonite.
Preferably, the diluent is water or grease.
Preferably, the filler is one or more of silica, vermiculite, alumina, kaolin, diatomaceous earth, zeolite, bentonite, calcium silicate, activated clay, polyethylene powder or polyamide powder.
The preparation process of the oxygen absorbing composition comprises the following steps: premixing a reducing agent, a catalyst and an adsorbent according to a set proportion, standing for 24-48 hours, and activating at a high temperature of 160-180 ℃ in vacuum to enable the reducing agent to become an active oxygen absorption component, wherein the activation degree of the reducing agent is 60-80%; the reducing agent is in the presence of a catalyst and an adsorbent, the adsorbent better collects oxygen after the reducing agent passes through vacuum and high temperature, and the catalyst can accelerate the chemical reaction of oxygen absorption between the reducing agent and the collected oxygen; adding an acid-base regulator into a diluent, uniformly dispersing, adding the diluent into a filler, mixing, and adding a humidity regulator to prepare a reaction base; finally, mixing the reactive group with the activated reducing agent to prepare the oxygen absorbing composition; the acid-base regulator is used for avoiding other abnormal gases from being released when the oxygen absorbent absorbs oxygen and is beneficial to promoting the oxygen insulation effect of the reducing agent; the humidity regulator is used for controlling the humidity of the environment for a specific application by the oxygen absorbent.
In the embodiment, the reducing agent is used for absorbing oxygen, the catalyst is used for accelerating the reducing agent to absorb oxygen, and the adsorbent is used for collecting oxygen in the medicinal package and reacting with the reducing agent to ensure that oxygen absorption is carried out and completed at a preset speed in a set time; the reducing agent absorbs oxygen in the closed space at a predetermined speed under the action of the catalyst and the adsorbent until the oxygen concentration is reduced to be below 0.1 percent, wherein the predetermined speed is that the oxygen absorption speed absorbs 10ml of oxygen every 24 hours under the condition of 25 ℃, such as the specification of 50ml or 250ml of air. The humidity regulator is used for regulating the humidity in the packaging bag to be within a preset range, the humidity range is set to be 25% -50%, the humidity is a storage humidity range which is suitable for solid medicines, if the humidity of a medicine storage environment is too high, the medicines can easily absorb moisture, and therefore the phenomena of deliquescence, denaturation, agglomeration and the like can occur, and at the moment, the medicines can also generate deterioration risks; however, the oxygen absorbent can generate water vapor during oxygen inhalation, and the humidity of the oxygen absorbent can rise to more than 80%, which is not favorable for the preservation of oral medicines.
The oxygen inhalation composition in the embodiment has good synergistic effect of all the components, good safety, no harm to the medicine and no influence on the medicine effect of the medicine. The oxygen concentration in the medicine bag can be reduced to be below 0.1 percent; the reducing agent absorbs oxygen in the closed space at a preset speed under the action of the catalyst, the adsorbent and the diluent, and can be completed within a specific time, wherein the specific time is no more than 7 days at the normal temperature of 25 ℃.
In another embodiment, a preparation method of a self-balancing oxygen inhalation composition for bagging medicine is provided, which comprises the following steps:
firstly, respectively selecting 40-60% of reducing agent, 0.1-0.5% of catalyst and 0.5-4% of adsorbent according to mass percent for premixing to obtain a mixture, standing the mixture for 24-48 hours, and then heating the mixture in a high-temperature vacuum environment at 160-180 ℃;
step two, adding 0.1-0.5% of acid-base regulator into 4-15% of diluent, uniformly dispersing, adding 10-30% of filler, mixing, and simultaneously adding 1-10% of humidity regulator to prepare a reaction base;
step three, mixing the mixture activated in the step one with the reaction group in the step two to prepare an oxygen absorbing composition;
step four, preparing a film through compression molding; the film material is Tyvek or polypropylene;
and step five, packaging the oxygen absorption composition prepared in the step three in a film to form the bagged oxygen absorbent.
In another embodiment, a device for preparing a self-balancing oxygen-absorbing composition for pharmaceutical pouches is provided, comprising: the blanking mechanism at least comprises a rotatable blanking rotating piece, a blanking pipe component with one end communicated with the blanking rotating piece, and a fixing piece abutted against the blanking pipe component; the pipe diameters of the blanking pipe assemblies are at least two different sizes; the fixing piece is provided with through holes matched with the inner diameters of the different pipes; the molding piece is arranged below the through hole; the film feeding mechanism is arranged below the blanking mechanism; the film feeding mechanism at least comprises: the film feeding assembly is used for providing a packaging film, and at least two groups of film pulling assemblies are arranged on two sides of the forming piece in a mirror image manner and are in contact with the outer surface of the packaging film formed on the forming piece; the film drawing assembly is arranged to assist the packaging film in moving in at least one direction; the packaging mechanism is arranged below the molding piece; the packaging mechanism is arranged to package the packaging film from at least two directions.
In a further embodiment, a plurality of groups of blanking hole units are arranged on the blanking rotating piece along the circumferential direction of the blanking rotating piece in an array manner; each group of blanking hole units comprises a first blanking hole and a second blanking hole; the aperture of the first blanking hole and the aperture of the second blanking hole are arranged according to a preset proportion;
the blanking pipe assembly comprises a plurality of groups of first blanking pipes and second blanking pipes which are respectively and correspondingly communicated with the first blanking holes and the second blanking holes; the inner diameter of the first blanking pipe is the same as the aperture of the first blanking hole, and the inner diameter of the second blanking pipe is the same as the aperture of the second blanking pipe;
the blanking mechanism also comprises a material hopper which is divided into at least two containing spaces, and at least two groups of material guiding pipes which are respectively communicated with different containing spaces in the material hopper; one of the material guiding pipes is communicated with the first blanking hole, and the other material guiding pipe is communicated with the second blanking hole.
Through the technical scheme: based on the oxygen absorption performance of the oxygen absorption composition, different mixtures are prepared and mixed, and the different mixtures are respectively discharged from a first discharging pipe and a second discharging pipe, so that the respective discharging is realized.
In a further embodiment, further comprising: the first material receiving pipe is arranged below the through hole; the input end of the first material receiving pipe is connected to the lower surface of the fixing piece; the second material receiving pipe is transversely communicated with the output end of the first material receiving pipe; the rotating piece is arranged in the second material receiving pipe along the length direction of the second material receiving pipe; the rotating piece is provided with a helical blade along the length direction; the third material receiving pipe is communicated with the output end of the second material receiving pipe; the third material receiving pipe is arranged right above the forming part.
Through the technical scheme: when the two mixtures are transported in the second material receiving pipe, the two mixtures not only move horizontally, but also move vertically due to gravity, and in the movement of the two directions, the two mixtures are fully mixed, so that the different components in the finally packaged oxygen absorption composition are uniformly mixed, and the oxygen absorption effect is improved.
In a further embodiment, the film pulling assembly comprises: driving motor, connect in the reduction gear of driving motor output connects in the first universal joint of reduction gear output, connect in the second universal joint of first universal joint, through the splined connection in the third universal joint of second universal joint, connect in the fourth universal joint of third universal joint, one end connect in the action wheel transmission shaft of fourth universal joint, connect in the action wheel of the action wheel transmission shaft other end, and connect in through synchronous belt drive the follower of action wheel.
Through the technical scheme: the synchronous belt motion is realized, the surface of the synchronous belt contacts with the outer surface of the packaging film, so that the packaging film is driven to move downwards, the packaging film is unreeled, and the packaging film filled with the oxygen absorption composition enters a packaging process.
In a further embodiment, further comprising: one end of the wheel tensioning adjusting plate is sleeved on the driving wheel transmission shaft through a bearing; the other end of the wheel tensioning adjusting plate is provided with a through groove; one end of the tensioning connecting shaft is connected to the driven wheel through a bearing, and the other end of the tensioning connecting shaft penetrates through the through groove and extends out of the wheel tensioning adjusting plate; and the tensioning shaft pad is in threaded connection with the other end of the tensioning connecting shaft.
Through the technical scheme: the height of the tensioning connecting shaft is adjusted by adjusting the position of the tensioning shaft pad on the through groove, the height of the driven wheel is adjusted, and tensioning adjustment of the synchronous wheel is achieved.
Has the advantages that: the oxygen absorption composition prepared by the invention is applied to oxygen absorption in medicine bags, so that the oxygen concentration in the medicine bags is reduced to be below 0.1%, the storage humidity of the medicines in the packaging bags is controlled within a proper range, the relative humidity is automatically balanced to the storage humidity suitable for oral administration, and the defect that the humidity of a conventional oxygen absorbent rises during oxygen absorption is overcome; the packaging film bag of the oxygen absorbent has very high safety, such as bacteria resistance, water resistance, air permeability, particle barrier property, tensile strength, tearing property and bursting resistance, can absorb oxygen, has a good oxygen insulation function, and also has good capability of controlling humidity.
Drawings
FIG. 1 is a schematic representation of an edge seal type of oxygen absorbing composition package of the present invention.
FIG. 2 is a view showing the structure of a manufacturing apparatus of the present invention.
Fig. 3 is a plan view of the blanking mechanism.
Fig. 4 is a schematic structural view of the second material receiving pipe and the rotating member.
FIG. 5 is a front view of the manufacturing apparatus of the present invention.
Fig. 6 is a schematic structural view of the film feeding assembly.
Fig. 7 is a schematic structural view of a film drawing assembly.
Fig. 8 is a schematic structural view of a film drawing assembly.
In fig. 1 to 8, the respective symbols are: the device comprises a blanking mechanism 10, a blanking rotating part 11, a fixing part 12, a first blanking hole 13, a second blanking hole 14, a first blanking pipe 15, a second blanking pipe 16, a material hopper 17, a material guiding pipe 18, a first material receiving pipe 19, a second material receiving pipe 110, a rotating part 111, a third material receiving pipe 112, a formed part 20, a film feeding mechanism 30, a main rotating roller 31, an auxiliary rotating roller 32, a driving motor 33, a speed reducer 34, a first universal joint 35, a second universal joint 36, a third universal joint 37, a fourth universal joint 38, a driving wheel transmission shaft 39, a driving wheel 310, a driven wheel 311, a wheel tensioning adjusting plate 312, a through groove 313, a tensioning connecting shaft 314, a tensioning shaft pad 315, a packaging mechanism 40 and a packaging film 50.
Detailed Description
Example 1
Respectively selecting 10% of copper powder, 37% of iron powder, 0.2% of sodium chloride and 3% of activated carbon according to the mass percentage, premixing to obtain a mixture, standing the mixture for 25 hours, heating the mixture in a high-temperature vacuum environment at 170 ℃, and activating a reducing agent in the mixture after heating treatment; adding 0.2% of calcium hydroxide into 13% of water, uniformly dispersing, adding 17.8% of silicon dioxide, 10% of diatomite and 2% of polyamide powder, mixing, and simultaneously adding 7% of calcium chloride and 2% of silica gel to prepare a reaction base; mixing the activated mixture with a reactive group to prepare an oxygen absorbing composition; preparing a film by press molding; the film material is Tyvek or polypropylene; packaging the prepared oxygen absorbing composition into a film to form the bagged oxygen absorbing agent. The bagged oxygen absorbent is put into a high-barrier closed package containing medicines and used for absorbing oxygen and controlling humidity, and the oxygen concentration and the humidity in the high-barrier closed package are tested in real time. The test equipment for measuring the oxygen concentration in the medicine package is an R0-103KS oxygen analyzer which is independently developed and produced by Nippon Kaishan electronic industry corporation, and the oxygen content in the gas in the package is measured by enabling the gas in the package to flow through an oxygen sensor arranged in the equipment through a sampling device, wherein the sampling device of the equipment comprises a sampling needle and a gas collecting device; the humidity in the medicine package is measured by a temperature and humidity self-recording instrument. The result determination shows that the oxygen absorption speed of the oxygen absorption composition is that 10ml of oxygen is absorbed every 24 hours at the temperature of 25 ℃, and the oxygen concentration in the medicine packaging bag is reduced to be below 0.1 percent; and the humidity in the medicine packaging bag is within the range of 25-50%. The conventional oxygen absorbent only reduces the oxygen concentration in the packaging bag to 0.5 percent and has the relative humidity of 70 percent; the oxygen absorbent of the embodiment reduces the oxygen concentration in the packaging bag to be below 0.1 percent and the relative humidity to be below 50 percent; compared with the conventional oxygen absorbent, the oxygen absorbent of the embodiment has better oxygen absorption degree and better humidity reduction effect, and is more suitable for medicine oxygen absorption. The following figure shows the test data of the oxygen absorbent of this example (taking 50ml as an example of product specification):
| time of measurement | 0h | 24h | 48h | 72h | 96h | 120h |
| Oxygen uptake | 0ml | 10 |
20 |
30 |
40 |
50 ml |
| Humidity RH | 65% | 72% | 55% | 52% | 45% | 43% |
Example 2
Respectively selecting 50% of aluminum powder, 0.3% of zinc chloride and 2% of activated carbon according to the mass percentage, premixing to obtain a mixture, standing the mixture for 25 hours, heating the mixture in a high-temperature vacuum environment at 170 ℃, and activating a reducing agent in the mixture after heating treatment; adding 0.2% of sodium hydroxide into 13% of water, uniformly dispersing, adding 17.8% of vermiculite, 10% of zeolite and 2% of polyethylene powder, mixing, and simultaneously adding 3% of montmorillonite and 2% of silica gel to prepare a reaction base; mixing the activated mixture with a reactive group to prepare an oxygen absorbing composition; preparing a film by press molding; the film material is Tyvek or polypropylene; packaging the prepared oxygen absorbing composition into a film to form the bagged oxygen absorbing agent. The bagged oxygen absorbent is put into a high-barrier closed package containing medicines and used for absorbing oxygen and controlling humidity, and the oxygen concentration and the humidity in the high-barrier closed package are tested in real time. The method of measuring the oxygen concentration and humidity in the pharmaceutical product package was the same as in example 1. The result shows that the oxygen absorbing speed of the oxygen absorbing composition is that the oxygen absorbing composition absorbs about 10ml of oxygen every 24 hours at the temperature of 25 ℃, and the oxygen concentration in the medicine packaging bag is reduced to be below 0.1 percent; and the humidity in the medicine packaging bag is within the range of 25-50%.
Example 3
Respectively selecting 9% of zinc powder, 30% of iron carbide, 0.2% of zinc chloride and 3% of montmorillonite according to the mass percentage, premixing to obtain a mixture, standing the mixture for 26 hours, heating the mixture in a high-temperature vacuum environment at 165 ℃, and activating a reducing agent in the mixture after heating treatment; adding 0.2% of sodium bicarbonate into 13% of grease, uniformly dispersing, adding 17.8% of silicon dioxide, 10% of diatomite and 2% of active clay, mixing, and simultaneously adding 5% of magnesium chloride to prepare a reaction base; mixing the activated mixture with a reactive group to prepare an oxygen absorbing composition; preparing a film by press molding; the film material is Tyvek or polypropylene; packaging the prepared oxygen absorbing composition into a film to form the bagged oxygen absorbing agent. The bagged oxygen absorbent is put into a high-barrier closed package containing medicines and used for absorbing oxygen and controlling humidity, and the oxygen concentration and the humidity in the high-barrier closed package are tested in real time. The method of measuring the oxygen concentration and humidity in the pharmaceutical product package was the same as in example 1. The result shows that the oxygen absorbing speed of the oxygen absorbing composition is that the oxygen absorbing composition absorbs about 10ml of oxygen every 24 hours at the temperature of 25 ℃, and the oxygen concentration in the medicine packaging bag is reduced to be below 0.1 percent; and the humidity in the medicine packaging bag is within the range of 25-50%.
Example 4
Respectively selecting 45% of iron silicide, 0.3% of ferric chloride and 3% of active carbon according to the mass percentage, premixing to obtain a mixture, standing the mixture for 27 hours, heating the mixture in a high-temperature vacuum environment at 175 ℃, and activating a reducing agent in the mixture after heating treatment; adding 0.4% of sodium carbonate into 10% of water, uniformly dispersing, adding 20% of vermiculite, 9% of calcium silicate and 2% of polyamide powder together, mixing, and simultaneously adding 5% of alumina and 3% of bentonite to prepare a reaction base; mixing the activated mixture with a reactive group to prepare an oxygen absorbing composition; preparing a film by press molding; the film material is Tyvek or polypropylene; packaging the prepared oxygen absorbing composition into a film to form the bagged oxygen absorbing agent. The bagged oxygen absorbent is put into a high-barrier closed package containing medicines and used for absorbing oxygen and controlling humidity, and the oxygen concentration and the humidity in the high-barrier closed package are tested in real time. The method of measuring the oxygen concentration and humidity in the pharmaceutical product package was the same as in example 1. The result shows that the oxygen absorbing speed of the oxygen absorbing composition is that the oxygen absorbing composition absorbs about 10ml of oxygen every 24 hours at the temperature of 25 ℃, and the oxygen concentration in the medicine packaging bag is reduced to be below 0.1 percent; and the humidity in the medicine packaging bag is within the range of 25-50%.
Example 5
Respectively selecting 9% of ferrous sulfate, 28% of sodium sulfite, 0.5% of sodium chloride and 4% of montmorillonite according to the mass percentage, premixing to obtain a mixture, standing the mixture for 40 hours, heating the mixture in a high-temperature vacuum environment at 180 ℃, and activating a reducing agent in the mixture after heating treatment; adding 0.4% of sodium carbonate into 15% of grease, uniformly dispersing, adding 10% of silicon dioxide, 20% of kaolin and 3% of active clay together, mixing, and simultaneously adding 2.3% of alumina and 4% of bentonite to prepare a reaction base; mixing the activated mixture with a reactive group to prepare an oxygen absorbing composition; preparing a film by press molding; the film material is Tyvek or polypropylene; packaging the prepared oxygen absorbing composition into a film to form the bagged oxygen absorbing agent. The bagged oxygen absorbent is put into a high-barrier closed package containing medicines and used for absorbing oxygen and controlling humidity, and the oxygen concentration and the humidity in the high-barrier closed package are tested in real time. The method of measuring the oxygen concentration and humidity in the pharmaceutical product package was the same as in example 1. The result shows that the oxygen absorbing speed of the oxygen absorbing composition is that the oxygen absorbing composition absorbs about 10ml of oxygen every 24 hours at the temperature of 25 ℃, and the oxygen concentration in the medicine packaging bag is reduced to be below 0.1 percent; and the humidity in the medicine packaging bag is within the range of 25-50%.
Example 6
Respectively selecting 30% of zinc powder, 11% of sodium erythorbate, 0.3% of sodium chloride and 3% of activated carbon according to the mass percent, premixing to obtain a mixture, standing the mixture for 38 hours, heating the mixture in a high-temperature vacuum environment at 169 ℃, and activating a reducing agent in the heated mixture; adding 0.4% of calcium hydroxide into 15% of grease, uniformly dispersing, adding 18% of silicon dioxide, 8% of diatomite and 3% of polyethylene powder, mixing, and simultaneously adding 5% of alumina and 1% of silica gel to prepare a reaction base; mixing the activated mixture with a reactive group to prepare an oxygen absorbing composition; preparing a film by press molding; the film material is Tyvek or polypropylene; packaging the prepared oxygen absorbing composition into a film to form the bagged oxygen absorbing agent. The bagged oxygen absorbent is put into a high-barrier closed package containing medicines and used for absorbing oxygen and controlling humidity, and the oxygen concentration and the humidity in the high-barrier closed package are tested in real time. The method of measuring the oxygen concentration and humidity in the pharmaceutical product package was the same as in example 1. The result shows that the oxygen absorbing speed of the oxygen absorbing composition is that the oxygen absorbing composition absorbs about 10ml of oxygen every 24 hours at the temperature of 25 ℃, and the oxygen concentration in the medicine packaging bag is reduced to be below 0.1 percent; and the humidity in the medicine packaging bag is within the range of 25% -50%.
Example 7
The embodiment provides a preparation device of a self-balancing oxygen absorption composition for bagging medicines, which is used for realizing the packaging of the oxygen absorption composition and forming a bagged oxygen absorption agent in the embodiment, and comprises a blanking mechanism 10, a forming part 20, a film feeding mechanism 30 and a packaging mechanism 40; the blanking mechanism 10 at least comprises a blanking rotating part 11, a blanking pipe component and a fixing part 12; the blanking rotating piece 11 has a degree of freedom capable of rotating, in the embodiment, the blanking rotating piece 11 is a blanking turntable, and the rotation of the blanking rotating piece 11 can be realized by adopting the transmission of a motor driving gear; one end of the blanking pipe assembly is communicated with the blanking rotating piece 11, and the blanking pipe assembly at least comprises two different sizes and pipe diameters; in this embodiment, based on the preparation process of the oxygen absorbing composition (based on the above-mentioned third step), the blanking tube assembly is set to have two different sizes and tube diameters; the fixing member 12 is a fixed disk, the fixing member 12 is fixed in position, the blanking pipe assemblies on the upper surface of the fixing member 12 are abutted, the fixing member 12 is provided with a set of through holes matched with the blanking pipe assemblies in different pipe diameters, in other words, the blanking pipe assemblies in the embodiment comprise two different pipe diameters, the fixing member 12 is provided with a set of through holes, the set of through holes comprises two through holes, and the sizes of the two through holes are respectively equal to the inner diameters of the two different pipe diameters in the blanking pipe assemblies. The forming part 20 is arranged below the through hole, and the forming part 20 is a former in a packaging machine in the prior art; the film feeding mechanism 30 is arranged below the side of the blanking mechanism 10; the film feeding mechanism 30 at least comprises a film feeding assembly and at least two groups of film pulling assemblies arranged on two sides of the forming part 20 in a mirror image manner; the film feeding assembly is used for providing a packaging film 50 and comprises a rack, a main rotating roller 31 and an auxiliary rotating roller 32, wherein the main rotating roller 31 is arranged at the lower end of the rack, and the auxiliary rotating roller 32 is sequentially arranged from bottom to top; the main roller 31 is used for placing the rolled packaging film 50 and the unreeled packaging film 50; the auxiliary rotating rollers 32 are arranged from bottom to top in sequence from front to back, and the auxiliary rotating rollers 32 are used for guiding the packaging film 50 to move and realizing the smooth movement of the packaging film 50; the packaging film 50 is guided from the unwinding roll of the main roller 31 to the forming member 20 through the auxiliary roller 32, is formed on the forming member 20 and extends downwards along the forming member 20; the film drawing assembly is in contact with the packaging film 50 which is formed on the forming member 20 and extends downwards, and the film drawing assembly is used for assisting the packaging film 50 to move downwards and providing power for unreeling the packaging film 50. The encapsulating mechanism 40 is disposed below the molding member 20, and the encapsulating mechanism 40 includes a horizontal sealing device and a vertical sealing device, which are commonly found in the prior art, and the detailed structure is not described herein. The cross sealer and the longitudinal sealer accomplish the transverse and longitudinal sealing of the packaging film 50, respectively.
Step three of the preparation method of the self-balancing oxygen absorption composition for bagging the medicines is to mix the activated mixture in the step one and the reaction group in the step two to prepare the oxygen absorption composition, so that the step three needs to mix two different mixtures and then package the mixtures; the different proportions of the components in the oxygen absorption composition can lead to different oxygen absorption effects; in order to ensure the oxygen absorbing effect of the oxygen absorbing composition, the components in the oxygen absorbing composition need to be mixed according to the proportion (the specific proportion is shown in the above examples); before the oxygen absorbing composition is packaged, if the seven major components are firstly mixed integrally and then packaged, the stirring device brings huge pressure and causes uneven mixing, and the proportion of the components in the packaged oxygen absorbing composition does not conform to the proportion in the embodiment, so that the oxygen absorbing effect of the oxygen absorbing composition is influenced; in order to solve the problem, the following technical scheme is proposed:
a plurality of groups of blanking hole units are arranged on the blanking rotating piece 11 in an array manner along the circumferential direction of the blanking rotating piece, and each group of blanking hole units comprises a first blanking hole 13 and a second blanking hole 14; the apertures of the first blanking hole 13 and the second blanking hole 14 are arranged according to a preset proportion; the predetermined ratio is set in accordance with the ratio of the respective components in the above-described examples. The specific description is as follows: the oxygen absorption composition comprises, by mass, 40-60% of a reducing agent, 0.1-0.5% of a catalyst, 1-10% of a humidity regulator, 0.1-0.5% of an acid-base regulator, 0.5-4% of an adsorbent, 4-15% of a diluent and 10-30% of a filler; the mixture in the first step consists of a reducing agent, a catalyst and an adsorbent, and the mixture in the second step consists of an acid-base regulator, a diluent, a filling agent and a humidity regulator; the mixture ratio in the step one and the mixture ratio in the step two are respectively as follows: (40.65% -64.5%): (15.15% -55.55%) and the two mixtures add up to 100%; preferably, the ratio of the two mixtures is 60%:40%, 3:2, whereby the aperture between the first blanking hole 13 and the second blanking hole 14 is 3:2. The blanking pipe assembly comprises a plurality of groups of first blanking pipes 15 and second blanking pipes 16, the heights of the first blanking pipes 15 and the heights of the second blanking pipes 16 are the same, and openings are formed at two ends of each of the first blanking pipes 15 and the second blanking pipes 16 and are specifically divided into upper openings and lower openings; the first blanking pipes 15 are respectively and fixedly communicated with the first blanking holes 13, and the second blanking pipes 16 are respectively and fixedly communicated with the second blanking holes 14; the inner diameter of the first blanking pipe 15 is the same as the aperture of the first blanking hole 13, and the inner diameter of the second blanking pipe 16 is the same as the aperture of the second blanking pipe 16. The blanking mechanism 10 also comprises a material hopper 17 and a material guiding pipe 18; in the present embodiment, the material hopper 17 is divided into two accommodating spaces, one of which is used for accommodating the mixture in the first step, and the other is used for accommodating the mixture in the second step; the two groups of material guiding pipes 18 are respectively communicated with different accommodating spaces in the material hopper 17; one of the material guiding pipes 18 is communicated with the first blanking hole 13, and the other material guiding pipe 18 is communicated with the second blanking hole 14. In the initial position, the two groups of material guiding pipes 18 are respectively communicated with the first blanking hole 13 and the second blanking hole 14, different mixtures are respectively blanked from the respective corresponding material guiding pipes 18 and respectively pass through the first blanking hole 13 and the second blanking hole 14 to the first blanking pipe 15 and the second blanking pipe 16, and the fixing plate blocks the lower openings of the first blanking pipe 15 and the second blanking pipe 16; the blanking rotating part 11 rotates to drive the first blanking pipe 15, the second blanking pipe 16 and materials therein to rotate to the through hole of the fixing plate, the lower openings of the first blanking pipe 15 and the second blanking pipe 16 are aligned with the corresponding through holes respectively, and then the blanking of the materials into the forming part 20 is realized. In the process, the two mixtures fed into the molding part 20 each time are mixed in small dosage (meeting the dosage of each bag), so that the ratio of each component in the packaged oxygen absorption composition is accurate, and the oxygen absorption effect is ensured.
The oxygen absorption effect of the oxygen absorption composition not only is the proportion of each component, but also is the mixing uniformity of each component, the higher the mixing uniformity is, the better the synergistic effect among each component is, for this reason, in order to improve the mixing degree among each component, the following technical scheme is proposed:
in a further embodiment, further comprising: a first receiving pipe 19, a second receiving pipe 110, a rotating member 111, and a third receiving pipe 112; the first material receiving pipe 19 is provided with openings at two ends, the first material receiving pipe 19 is positioned below the through hole Fang Judi, and the input end of the first material receiving pipe 19 is fixedly connected with the lower surface of the fixing piece 12; the second material receiving pipe 110 is transversely communicated with the first material receiving pipe 19, and the second material receiving pipe 110 is horizontally arranged; the rotating member 111 is arranged in the second material receiving pipe 110 along the length direction of the second material receiving pipe 110, one end of the rotating member 111 extends to the outside of the second material receiving pipe 110 and is connected to the driving motor 33, the rotating member 111 is a rotating shaft, the driving motor 33 is used for driving the rotating member 111 to rotate, and the rotating member 111 is fixedly provided with a helical blade along the length direction; a third material receiving pipe 112 is communicated with the output end of the second material receiving pipe 110, and the third material receiving pipe 112 is positioned right above the forming part 20; when the two mixtures fall into the first material receiving pipe 19 from the through hole of the fixed part 12 and then fall into the input end of the second material receiving pipe 110 due to the gravity, the driving motor 33 drives the rotating part 111 to rotate, so that the helical blade rotates, and the rotating helical blade transports the two mixtures to the output end of the second material receiving pipe 110 and falls into the third material receiving pipe 112, so that the two mixtures fall into the formed part 20; when the two mixtures are transported in the second material receiving pipe 110, the two mixtures not only move horizontally, but also move vertically due to gravity, and the two mixtures are fully mixed in the movement in two directions, so that the different components in the finally packaged oxygen absorption composition are uniformly mixed, and the oxygen absorption effect is improved.
In a further embodiment, a film drawing assembly comprises: a driving motor 33, a speed reducer 34, a first universal joint 35, a second universal joint 36, a third universal joint 37, a fourth universal joint 38, a driving wheel 310 transmission shaft 39, a driving wheel 310, a driven wheel 311 and a wheel tension adjusting plate 312; the output end of the driving motor 33 is connected with the input end of the speed reducer 34, the output end of the speed reducer 34 is connected with one end of the first universal joint 35, and the speed reducer adopts a worm gear speed reducer; the other end of first universal joint 35 is articulated (accessible cross joint is realized) with second universal joint 36, the other end of second universal joint 36 passes through splined connection with third universal joint 37, the other end of third universal joint 37 is articulated (accessible cross joint is realized) with fourth universal joint 38, the one end and the fourth universal joint 38 fixed connection of driving transmission shaft, driving transmission shaft's the other end and action wheel 310 fixed connection, pass through synchronous belt drive between action wheel 310 and the driven wheel 311 and be connected. The output end of the driving motor 33 is connected with the input end of the speed reducer, and the output end of the speed reducer is connected with the first universal joint 35, so as to drive the first universal joint 35 to rotate, further drive the second universal joint 36, the third universal joint 37, the fourth universal joint 38 and the driving transmission shaft to rotate, further drive the driving wheel 310 to rotate, and further realize the rotation of the synchronous belt; the surface of the synchronous belt is in contact with the outer surface of the packaging film 50, the synchronous belt moves to drive the packaging film 50 to move downwards, the packaging film 50 is unreeled, and the packaging film 50 filled with the oxygen absorption composition enters a packaging process; realize the transmission of initiative transmission shaft through first universal joint 35, second universal joint 36, third universal joint 37 and fourth universal joint 38, reduced transmission error, improve the precision of hold-in range motion, and then realize accurate unreeling. In order to solve the problem, a wheel tensioning adjusting plate 312 is arranged on a synchronous belt transmission system; one end of the wheel tensioning adjusting plate 312 is sleeved on the driving transmission shaft through a bearing, the other end of the wheel tensioning adjusting plate 312 is connected with the driven wheel 311 through a tensioning connecting shaft 314, and the end part is provided with a through groove 313; one end of the tensioning connecting shaft 314 is connected with the driven wheel 311 through a bearing, the other end of the tensioning connecting shaft 314 extends to the outside through the through groove 313, and a tensioning shaft pad 315 is connected to the end through a thread, that is, the tensioning shaft pad 315 is connected to the tensioning connecting shaft 314 through a thread. The tensioning shaft pad 315 is adjusted in position on the through groove 313, so that the height of the tensioning connecting shaft 314 is adjusted, the height of the driven wheel 311 is adjusted, and the tensioning adjustment of the synchronous wheel is realized.
Claims (10)
1. A self-balancing oxygen absorption composition for medicine bagging is characterized by comprising the following components in percentage by mass:
40-60% of reducing agent
0.1 to 0.5 percent of catalyst
1-10% of humidity regulator
0.1% -0.5% of acid-base regulator
0.5% -4% of adsorbent
4 to 15 percent of diluent
10-30% of filler.
2. The self-balancing oxygen-absorbing composition for pharmaceutical bags according to claim 1,
the reducing agent is one or a combination of several of reduced iron powder, copper powder, aluminum powder, zinc powder, iron carbide, iron hydroxylation, iron silicide, ferrous sulfate, sodium sulfite, sodium erythorbate and sodium sulfite.
3. The self-balancing oxygen-absorbing composition for pharmaceutical bags according to claim 1,
the catalyst is one of potassium bromide, sodium chloride, zinc chloride or ferric chloride.
4. The self-balancing oxygen-absorbing composition for pharmaceutical bags according to claim 1,
the humidity regulator is one or a combination of more of montmorillonite, calcium chloride, silica gel, alumina, bentonite or magnesium chloride.
5. A preparation method of a self-balancing oxygen absorption composition for bagging medicines is characterized by comprising the following steps:
firstly, respectively selecting 40-60% of reducing agent, 0.1-0.5% of catalyst and 0.5-4% of adsorbent according to mass percent for premixing to obtain a mixture, standing the mixture for 24-48 hours, and then heating the mixture in a high-temperature vacuum environment at 160-180 ℃;
step two, adding 0.1-0.5% of acid-base regulator into 4-15% of diluent, uniformly dispersing, adding 10-30% of filler, mixing, and simultaneously adding 1-10% of humidity regulator to prepare a reaction base;
step three, mixing the activated mixture in the step one with the reactive group in the step two to prepare an oxygen absorbing composition;
step four, preparing a film through compression molding; the film material is Tyvek or polypropylene;
and step five, packaging the oxygen absorption composition prepared in the step three in a film to form the bagged oxygen absorbent.
6. A preparation device of a self-balancing oxygen absorption composition for bagging medicine is used for packaging the oxygen absorption composition, and is characterized by comprising the following components:
the blanking mechanism at least comprises a rotatable blanking rotating piece, a blanking pipe assembly with one end communicated with the blanking rotating piece, and a fixing piece abutted against the blanking pipe assembly; the pipe diameters of the blanking pipe assemblies are at least two different sizes; the fixing piece is provided with through holes matched with the inner diameters of the different pipes;
the molding piece is arranged below the through hole;
the film feeding mechanism is arranged below the blanking mechanism; the film feeding mechanism at least comprises: the film pulling assembly is arranged on the two sides of the forming piece in a mirror image mode and is in contact with the outer surface of the packaging film formed on the forming piece; the film drawing assembly is arranged to assist the packaging film in moving in at least one direction;
the packaging mechanism is arranged below the molding piece; the packaging mechanism is arranged to package the packaging film from at least two directions.
7. The apparatus for preparing a self-balancing oxygen-absorbing composition for bagging of claim 6, wherein a plurality of sets of blanking hole units are arranged on the blanking rotating member along the circumferential direction; each group of blanking hole units comprises a first blanking hole and a second blanking hole; the aperture of the first blanking hole and the aperture of the second blanking hole are arranged according to a preset proportion;
the blanking pipe assembly comprises a plurality of groups of first blanking pipes and second blanking pipes which are respectively and correspondingly communicated with the first blanking holes and the second blanking holes; the inner diameter of the first blanking pipe is the same as the aperture of the first blanking hole, and the inner diameter of the second blanking pipe is the same as the aperture of the second blanking pipe;
the blanking mechanism also comprises a material hopper which is divided into at least two containing spaces, and at least two groups of material guiding pipes which are respectively communicated with different containing spaces in the material hopper; one of the material guiding pipes is communicated with the first blanking hole, and the other material guiding pipe is communicated with the second blanking hole.
8. The apparatus of claim 7, further comprising:
the first material receiving pipe is arranged below the through hole; the input end of the first material receiving pipe is connected to the lower surface of the fixing piece;
the second material receiving pipe is transversely communicated with the output end of the first material receiving pipe;
the rotating piece is arranged in the second material receiving pipe along the length direction of the second material receiving pipe; the rotating piece is provided with a helical blade along the length direction of the rotating piece;
the third material receiving pipe is communicated with the output end of the second material receiving pipe; the third material receiving pipe is arranged right above the forming part.
9. The apparatus of claim 6, wherein the film drawing assembly comprises: driving motor, connect in the reduction gear of driving motor output connects in the first universal joint of reduction gear output, connect in the second universal joint of first universal joint, through the splined connection in the third universal joint of second universal joint, connect in the fourth universal joint of third universal joint, one end connect in the action wheel transmission shaft of fourth universal joint, connect in the action wheel of the action wheel transmission shaft other end, and connect in through synchronous belt drive the follower of action wheel.
10. The apparatus for preparing a self-balancing oxygen-absorbing composition for bagging of claim 9, further comprising:
one end of the wheel tensioning adjusting plate is sleeved on the driving wheel transmission shaft through a bearing; the other end of the wheel tensioning adjusting plate is provided with a through groove;
one end of the tensioning connecting shaft is connected to the driven wheel through a bearing, and the other end of the tensioning connecting shaft penetrates through the through groove and extends out of the wheel tensioning adjusting plate;
and the tensioning shaft pad is in threaded connection with the other end of the tensioning connecting shaft.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210564313.4A CN115193243A (en) | 2022-05-23 | 2022-05-23 | Self-balancing oxygen inhalation composition for medicine bagging, and preparation device and preparation method thereof |
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| CN202210564313.4A CN115193243A (en) | 2022-05-23 | 2022-05-23 | Self-balancing oxygen inhalation composition for medicine bagging, and preparation device and preparation method thereof |
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