CN115192718A - 抗cd47的单克隆抗体及其用途 - Google Patents

抗cd47的单克隆抗体及其用途 Download PDF

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Publication number
CN115192718A
CN115192718A CN202210394792.XA CN202210394792A CN115192718A CN 115192718 A CN115192718 A CN 115192718A CN 202210394792 A CN202210394792 A CN 202210394792A CN 115192718 A CN115192718 A CN 115192718A
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seq
variant
antibody
amino acid
sequence
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Chinese (zh)
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李百勇
夏瑜
王忠民
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Akeso Pharmaceuticals Inc
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Akeso Biopharma Inc
Akeso Pharmaceuticals Inc
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/567—Framework region [FR]
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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CN202210394792.XA 2021-04-14 2022-04-14 抗cd47的单克隆抗体及其用途 Pending CN115192718A (zh)

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CN2021104040332 2021-04-14
CN202110404033 2021-04-14

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US (1) US20240043531A1 (https=)
EP (1) EP4190816A4 (https=)
JP (1) JP2024515396A (https=)
KR (1) KR20230170648A (https=)
CN (1) CN115192718A (https=)
AU (1) AU2022258273A1 (https=)
BR (1) BR112023018450A2 (https=)
CA (1) CA3193664A1 (https=)
IL (1) IL305363A (https=)
MX (1) MX2023010687A (https=)
WO (1) WO2022218384A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025077875A1 (zh) * 2023-10-13 2025-04-17 英脉德医疗科技(广东)有限公司 肿瘤微环境特异激活的cd47抗体
WO2025201450A1 (zh) * 2024-03-27 2025-10-02 康方汇科(上海)生物有限公司 药物组合及用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109053895B (zh) * 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
AU2020324185A1 (en) * 2019-08-02 2022-03-03 CTTQ-Akeso (ShangHai) Biomed. Tech. Co., Ltd. Anti-PD-1 antibody and medical use thereof
JP2025530041A (ja) * 2022-09-09 2025-09-11 中山康方生物医▲藥▼有限公司 治療用組合せ物とその使用
WO2026051964A1 (en) 2024-09-04 2026-03-12 Akeso Biopharma Co., Ltd. Antibody that binds vegfa and pd-1 and uses thereof to treat cancers

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CN112300280A (zh) * 2019-08-02 2021-02-02 正大天晴康方(上海)生物医药科技有限公司 一种抗pd-1抗体及其医药用途
CN112300286A (zh) * 2019-08-02 2021-02-02 康方药业有限公司 抗ctla4-抗pd-1双特异性抗体及其用途
CN112442123A (zh) * 2019-09-03 2021-03-05 中山康方生物医药有限公司 抗cd47的单克隆抗体及其用途
CN112830972A (zh) * 2019-11-25 2021-05-25 中山康方生物医药有限公司 抗pd-1-抗vegfa的双特异性抗体、其药物组合物及其用途

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ATE87659T1 (de) 1986-09-02 1993-04-15 Enzon Lab Inc Bindungsmolekuele mit einzelpolypeptidkette.
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
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WO2019109357A1 (zh) * 2017-12-08 2019-06-13 杭州翰思生物医药有限公司 抗pd-1/cd47的双特异性抗体及其应用
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CN112300286A (zh) * 2019-08-02 2021-02-02 康方药业有限公司 抗ctla4-抗pd-1双特异性抗体及其用途
CN112442123A (zh) * 2019-09-03 2021-03-05 中山康方生物医药有限公司 抗cd47的单克隆抗体及其用途
CN112830972A (zh) * 2019-11-25 2021-05-25 中山康方生物医药有限公司 抗pd-1-抗vegfa的双特异性抗体、其药物组合物及其用途

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025077875A1 (zh) * 2023-10-13 2025-04-17 英脉德医疗科技(广东)有限公司 肿瘤微环境特异激活的cd47抗体
WO2025201450A1 (zh) * 2024-03-27 2025-10-02 康方汇科(上海)生物有限公司 药物组合及用途

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US20240043531A1 (en) 2024-02-08
EP4190816A4 (en) 2025-04-02
MX2023010687A (es) 2023-09-22
WO2022218384A1 (zh) 2022-10-20
BR112023018450A2 (pt) 2023-11-07
IL305363A (en) 2023-10-01
AU2022258273A1 (en) 2023-09-14

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