CN115192656A - Traditional Chinese medicine composition for treating oligospermia and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating oligospermia and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating oligoasthenospermia as well as a preparation method and application thereof, belonging to the technical field of traditional Chinese medicine compositions, and comprising the following raw materials in parts by weight: 15-20 parts of semen cuscutae, 10-15 parts of flastem milkvetch seed, 10-15 parts of raspberry, 10-15 parts of fructus cnidii, 10-15 parts of wolfberry fruit, 10-15 parts of glossy privet fruit, 10-30 parts of schisandra chinensis, 15-30 parts of plantain seed, 10-15 parts of rose and 10-15 parts of lotus pistil. The invention also discloses a method for preparing decoction and pills by using the raw materials, and also discloses application of the traditional Chinese medicine composition in preparing a medicine for treating male kidney essence deficiency type oligospermia. Compared with western medicines, the traditional Chinese medicine composition has the advantages of small and refined dosage, small side effect, high safety and low cost, can be effectively applied to treating male kidney essence deficiency type oligospermia, and particularly has obvious advantages in the aspect of improving clinical Chinese medicine symptoms compared with the western medicines.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating oligospermia and a preparation method and application thereof.
Background
Oligospermia is a common disease in outpatient clinics of urology andrology, and the clinical manifestations are thin semen and poor sperm motility. In recent years, the incidence of infertility tends to increase year by year, and the world health organization statistics show that about 12% -15% of fertile couples worldwide have infertility problems, with male factors as high as 50%. The main reason of male infertility is oligospermia, however, specific treatment medicines for oligospermia in the prior art are still lacked, and empirical medicines are still used as main treatment medicines. The operation indications and the curative effect are very limited. Assisted reproduction solves some fertility problems, but still has the defects of low success rate, high cost, medical ethics, genetic risk and the like.
Therefore, how to provide an effective method for treating oligospermia in men is a technical problem to be solved urgently by those skilled in the art.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating oligospermia and a preparation method and application thereof.
In order to achieve the purpose, the invention provides the following scheme:
a traditional Chinese medicine composition for treating oligospermia comprises the following raw materials in parts by weight:
15-20 parts of semen cuscutae, 10-15 parts of semen astragali complanati, 10-15 parts of raspberry, 10-15 parts of fructus cnidii, 10-15 parts of wolfberry fruit, 10-15 parts of glossy privet fruit, 10-30 parts of schisandra chinensis, 15-30 parts of semen plantaginis, 10-15 parts of rose and 10-15 parts of lotus pistil.
Preferably, the feed comprises the following raw materials in parts by weight:
17-20 parts of semen cuscutae, 10-13 parts of semen astragali complanati, 10-13 parts of raspberry, 10-13 parts of fructus cnidii, 10-13 parts of wolfberry fruit, 10-13 parts of glossy privet fruit, 10-20 parts of schisandra chinensis, 15-23 parts of semen plantaginis, 10-15 parts of rose and 10-15 parts of lotus pistil.
Preferably, the feed comprises the following raw materials in parts by weight:
20 parts of dodder, 10 parts of flatstem milkvetch seed, 10 parts of raspberry, 10 parts of common cnidium fruit, 10 parts of medlar, 10 parts of glossy privet fruit, 10 parts of Chinese magnoliavine fruit, 20 parts of plantain seed, 10 parts of rose and 10 parts of lotus pistil.
Has the beneficial effects that: the Chinese medicinal formula adopts the kidney warming and yang strengthening of the dodder and the common cnidium fruit to assist the generation of sperm, namely the Chinese medicinal formula has the meaning of 'yin getting yang to generate infinite and yang getting yin to be yang but inexhaustible' and has the effect of promoting the generation of sperm; the medlar and the glossy privet fruit nourish yin and tonify the kidney as monarch drugs, and nourish the kidney yin to help the kidney yin to generate into genital essence; the semen astragali complanati, the raspberry, the schisandra chinensis and the lotus stamen are used as ministers to tonify and astringe the essence, so that the kidney essence is supplemented; semen plantaginis is used together with semen plantaginis for relieving dysentery, replenishing vital essence, strengthening yin, purging latent fire without causing deficiency fire to decoct yin essence, so as to prevent the dark consumption of yin essence; the rose is used for soothing the liver, dissipating stagnation, promoting blood circulation and regulating qi to dredge essence channels. The whole formula has the effects of nourishing yin, strengthening yang, tonifying kidney and replenishing essence. The whole formula has scientific and reasonable compatibility of monarch, minister, assistant and guide, and has the effects of nourishing yin and tonifying yang, and tonifying kidney and replenishing essence.
In addition, according to the explanation of modern medicine, the schisandra chinensis can directly capture oxygen free radicals, enhance the activity of antioxidant enzyme and reduce the damage of the free radicals to sperms; semen Cuscutae, fructus Lycii, and fructus Ligustri Lucidi can improve sperm quality, reduce sperm deoxyribonucleic acid (DNA) monoploid and polyploid, and increase normal haploid sperm; the lotus pistil contains more than twenty trace elements such as zinc, magnesium, selenium, calcium, iron, copper and the like, and the trace elements can promote the generation of sperms and improve the quality of the sperms. The rose added in the invention contains abundant components of polysaccharide, polyphenol, flavone and anthocyanin, has obvious antioxidation effect, and can effectively reduce the oxidative damage of sperms. The rose is rich in vitamin E, lycopene and other trace elements, and the vitamin E is called tocopherol, so that the rose has the effects of promoting secretion of male sex hormone, improving sperm quality and maintaining normal male fertility; lycopene has antioxidant effect. In addition, the rose can play the roles of anti-inflammation, antioxidation and immunoregulation by acting on the paths of PTGS2, NCOA2, PTGS1, BCL2, CASP9, JUN \ CASP3, CASP8 and the like, can effectively prevent the oxidative damage of sperms, and has certain curative effect on immune oligospermia. The lotus stamen Chinese medicine is also called lotus stamen which is sweet and astringent in taste, neutral in nature, and enters heart and kidney meridians, thus having the efficacy of reinforcing kidney and arresting seminal emission. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): it is usually used in the ancient recipe for strengthening true and tonifying, although it is not collected in the book Jing of stamen Nelumbinis. The main indications are those indicated for the disease of foot-Shaoyin channel, and also for dredging hand-Shaoyin channel, clearing heart fire, entering kidney to consolidate essence and qi, blackening beard and hair, stopping hematemesis, treating diarrhea and spermatorrhea, so it is the best to treat spermatorrhea and nocturnal emission. The experimental study shows that the traditional Chinese medicine composition has the function of regulating the hypothalamus-pituitary-gonad axis, and has the weak estrogen-like function which can be a source for tonifying kidney and securing essence in traditional Chinese medicine.
Researches show that the water decoction of rose and lotus stamen can reduce testis injury of rats caused by cadmium, increase the number of sperms of rats with testis injury and improve the sperm activity of rats. The levels of testosterone, FSH and LH and the ratio of LH/FSH in the blood serum of mice in the rose water decoction group are increased to different degrees, and the sexual behavior and fertility level of the mice are also improved. Cell proliferation cycle detection is carried out on the spermatogonial stem cells cultured in vitro for 1 week, and the number of the quercetin spermatogonial stem cells extracted by adding lotus stamen is found to be obviously increased, so that quercetin in lotus stamen is beneficial to promoting formation of spermatogenic cells.
The traditional Chinese medicine composition is scientific in components and reasonable in compatibility, supplements each other, and has the effects of nourishing yin, tonifying yang, tonifying kidney and producing sperm. The traditional Chinese medicine composition is clinically used for treating oligozoospermia, has good curative effect, high safety, no toxic or side effect, stable and lasting curative effect, has the effect of treating both symptoms and root causes, and is innovative in the aspect of treating oligozoospermia.
A preparation method of a traditional Chinese medicine composition for treating oligospermia is disclosed, wherein the traditional Chinese medicine composition is a decoction, and the specific preparation method comprises the following steps:
mixing the raw materials, soaking in water, decocting, filtering, collecting filtrate, adding water into the residue, repeating the decocting and filtering steps, and mixing the two filtrates to obtain the Chinese medicinal decoction.
Preferably, the soaking time is 30min;
the mass ratio of the raw materials to the water is 1;
and the mass ratio of the filter residue to the water is 1.
Preferably, the decoction comprises the following steps:
decocting with strong fire to boil, and decocting with slow fire for 30min.
A preparation method of a traditional Chinese medicine composition for treating oligospermia is provided, wherein the traditional Chinese medicine composition is a pill, and the preparation method specifically comprises the following steps:
heating Mel to boil for 3min, pulverizing the above materials respectively with pulverizer, mixing, adding into boiled Mel, and kneading into pill.
Preferably, the mixing is performed by thoroughly mixing the raw material powders in a mortar using a pestle.
Preferably, the mass ratio of the raw materials to the honey is 2.5:1; the pellets weigh 2g per pellet.
Application of a Chinese medicinal composition for treating oligospermia in preparing a medicament for treating male kidney essence deficiency type oligospermia is provided.
Compared with western medicines, the traditional Chinese medicine composition has the advantages of small dosage, small side effect, high safety and low cost, can be effectively used for treating male kidney essence deficiency type oligospermia, has the total effective rate of over 80.56 percent, and particularly has obvious advantages in the aspect of improving clinical Chinese medicine symptoms compared with the western medicines. Is an innovation of the medicine for treating male oligospermia and has practical clinical significance and popularization value.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In order to make the aforementioned objects, features and advantages of the present invention more comprehensible, embodiments accompanying the present invention are described in detail below.
Example 1
A traditional Chinese medicine composition for treating oligospermia comprises the following raw materials in parts by weight:
20 parts of dodder, 10 parts of milkvetch seed, 10 parts of raspberry, 10 parts of common cnidium fruit, 10 parts of medlar, 10 parts of glossy privet fruit, 10 parts of Chinese magnoliavine fruit, 20 parts of plantain seed, 10 parts of rose and 10 parts of lotus pistil.
A preparation method of a traditional Chinese medicine composition for treating oligospermia is disclosed, wherein the traditional Chinese medicine composition is a decoction, and the preparation process comprises the following steps:
mixing the raw material medicines, adding water with the mass of 6 times of the raw material medicines, soaking for 30min, decocting with strong fire until boiling, then decocting with slow fire for 30min, filtering, collecting filtrate, adding water into the filter residue according to the mass ratio of the filter residue to the water of 1.
Example 2
A method for preparing a Chinese medicinal composition for treating oligospermia, which is different from embodiment 1 in that the Chinese medicinal composition is a pill and the preparation process comprises the following steps:
the raw materials are respectively crushed by a crusher and then fully mixed in a mortar by a breast stick, the honey is heated and boiled for 3 minutes, and then the mixed raw material powder is added into the boiled honey, wherein the mass ratio of the raw material medicine to the honey is 2.5. And kneading the mixture of the honey and the mixed raw material powder into pills with the mass of 2g per pill to obtain the traditional Chinese medicine composition pills.
Example 3
Different from the embodiment 1, the traditional Chinese medicine composition for treating oligospermia comprises the following raw materials in parts by weight:
15 parts of semen cuscutae, 15 parts of semen astragali complanati, 15 parts of raspberry, 15 parts of fructus cnidii, 15 parts of fructus lycii, 15 parts of glossy privet fruit, 30 parts of schisandra chinensis, 30 parts of semen plantaginis, 15 parts of rose and 15 parts of lotus pistil.
Example 4
Different from the embodiment 1, the traditional Chinese medicine composition for treating oligospermia comprises the following raw materials in parts by weight:
20 parts of semen cuscutae, 12 parts of semen astragali complanati, 10 parts of raspberry, 10 parts of fructus cnidii, 10 parts of fructus lycii, 10 parts of glossy privet fruit, 20 parts of schisandra chinensis, 15 parts of semen plantaginis, 15 parts of rose and 15 parts of lotus pistil.
Comparative example 1
A traditional Chinese medicine composition for treating oligospermia is different from that in example 1 in that roses are not included in raw materials.
Comparative example 2
A traditional Chinese medicine composition for treating oligospermia is different from that in example 1 in that lotus stamen is not included in raw materials.
Comparative example 3
A traditional Chinese medicine composition for treating oligospermia is different from that in example 1 in that rose flowers and lotus pistils are not included in raw materials.
Technical effects
Model rats with gonadal suppression caused by Tripterygium wilfordii polyglycoside tablets are respectively subjected to blank treatment, 1L-carnitine oral liquid (northeast pharmaceutical company, batch number: 080301) per time (containing 1g of L-carnitine), rose non-decoction granules and lotus stamen non-decoction granules (wherein the rose non-decoction granules mainly contain flavonol, catechin, quercetin and quercetin, and the lotus stamen non-decoction granules mainly contain 4 effective components of quercetin, luteolin, kaempferol and isoquercitrin). Control studies were performed in 6 groups of 4 groups. L-carnitine is taken orally at twice, 2 times a day, 1 count each time, 15g of rose flower decoction-free granules and lotus stamen decoction-free granules are taken orally at twice. The blank was without any treatment. The treatment process lasted 4 weeks, the results are shown in tables 1 and 2, and the study results showed that both the group L-carnitine, rose and lotus stamen, whether sperm concentration or sperm motility, and hormone levels were significantly increased relative to the blank and the differences were statistically significant (P < 0.05). Further research shows that the flavonoid components extracted from rose flowers and lotus stamens can influence the hypothalamus-pituitary-gonad axis, reduce apoptosis of spermatogenic cells and increase the weight of testis and epididymis.
TABLE 1 sperm concentration before and after treatment
TABLE 2 PR + NP before and after treatment
1.1 case data
(1) The female is 20-45 years old, the sexual life is normal, the fertility of the female is normal, and no contraceptive measures are taken for more than 1 year after marriage but no pregnancy is performed;
(2) the diagnosis of oligospermia is met;
(3) it is suitable for diagnosing kidney deficiency and essence deficiency.
In the observation case, 72 patients with oligoasthenospermia are randomly divided into a treatment group and a control group, and each group comprises 36 patients. The control group is administered with levocarnitine oral liquid, and the treatment group is administered with the decoction of the traditional Chinese medicine composition for treating oligoasthenospermia obtained in the example 1 of the invention. The two treatment courses are 3 months, and the clinical curative effect and the change condition of the semen index are evaluated after 1 treatment course.
1.2 diagnostic criteria
The diagnosis standard of the traditional Chinese medicine syndrome:
and (3) master certificate:
1. the number of sperms is small; 2. weak activity; 3. the survival rate is low;
secondary verification:
1. soreness and weakness of waist and knees; 2. listlessness, spermatorrhea or premature ejaculation, frequent nocturia, amnesia, tinnitus; 3. white coating and weak pulse;
and (3) diagnosis:
the diagnosis was established with 3 items of the primary syndrome and 2 items of the secondary syndrome.
(II) Western diagnosis standard (oligoasthenospermia):
(1) the total amount of sperm is less than 39 × 10 6 Ejaculation every time;
(2) sperm concentration < 15X 10 6 /mL；
(3) The total sperm motility (PR + NP) < 40% or the forward motility (PR) < 32%.
The oligoasthenospermia can be diagnosed only by satisfying the diagnosis criteria of (1), (2) and (3).
1.3 treatment protocols
The traditional Chinese medicine prepared in the embodiment 1 of the invention is taken by a treatment group 2 times a day, 200-300ml each time, and is taken warmly 2 hours after breakfast and supper, the treatment course is 3 months, and the treatment effect is counted after 1 treatment course. During the treatment period, uncooked, cold, greasy and spicy foods are prohibited. The control group is administered with 1 oral tablet (containing 1g L-carnitine) 2 times per day (northeast pharmaceutical company, lot number: 080301).
1.4 diagnostic criteria for therapeutic efficacy
1. The observation indexes of the curative effect are as follows:
the semen index is detected before and after treatment. Abstinence is carried out for 2-7 days before examination, and semen is collected in a masturbation mode; after the semen is liquefied at 37 ℃, the conventional analysis of the semen is carried out by a full-automatic sperm analyzer according to WHO recommended standards. Mainly comprises a grade a sperms, a grade (a + b) sperms, sperm mobility and sperm density.
1.5, curative effect judgment standard:
(I) the clinical curative effect is assessed according to the relevant standards in the sterile couple standard examination and diagnosis handbook:
(1) healing, namely enabling the mate to conceive;
(2) the sperm motility returns to normal (the a + b grade is more than or equal to 50 percent), or the a grade is more than 25 percent, and the sperm motility is more than or equal to 60 percent);
(3) effectively, the sperm motility is improved by (a + b) grade is more than 30 percent, or the a grade is improved by more than 30 percent, and the sperm motility is improved by more than 30 percent;
(4) the sperm motility is not improved or the improvement degree does not reach the effective standard.
(II) according to the guidance principle of clinical research on new Chinese medicines, the evaluation standard of the Chinese medicinal effect score is formulated:
1. the clinical symptoms of insufficiency of kidney-yang disappear before and after treatment, and the symptom score is reduced by more than or equal to 95 percent.
2. Has obvious effects that the clinical symptoms of insufficiency of kidney-yang before and after treatment are obviously improved, and the syndrome score is reduced by 70 to 94 percent.
3. Has the effects of improving the clinical symptoms and physical signs of the kidney-yang deficiency before and after treatment and reducing the syndrome score by 30 to 69 percent.
4. The traditional Chinese medicine composition has no effect, the symptoms of insufficiency of kidney-yang before and after treatment are not obviously improved, and the symptom score is reduced by less than 30%.
1.6. Statistical method
Statistical methods statistical analysis of the test data was performed using SPSS10.0 software. The measurement data is expressed in x +/-s, and t test is adopted; ridit analysis was used for the grade data. All statistical tests are bilateral tests, and differences of P less than or equal to 0.05 have statistical significance.
1.7. Therapeutic results
According to the treatment scheme, the treatment group and the control group are respectively orally taken with the traditional Chinese medicine decoction and the levocarnitine oral liquid in the embodiment 1 of the invention, and 72 patients suffering from oligoasthenospermia are treated, and the treatment effect is counted after 1 treatment course. The total effective rates of the treatment group and the control group are respectively 80.56% and 82.35%; compared with the clinical curative effect among groups, the difference has no statistical significance (P is more than 0.05). Compared with the two groups before and after treatment, the a-grade sperms, the (a + b) -grade sperms, the sperm motility rate and the sperm density difference have statistical significance (P is less than 0.05). The differences in sperm count and sperm count for class a compared after treatment between groups were statistically significant (P < 0.05). The treated group was superior to the control group. The research result shows that the total effective rate of the treatment group is 80.56%, the clinical curative effect of the treatment group is equivalent to that of a western medicine control group (P is more than 0.05), and the treatment group has obvious advantage in improving sperm density (P is less than 0.05). The traditional Chinese medicine composition for treating oligoasthenospermia in embodiment 1 of the invention is effectively used for treating male asthenospermia, and has certain clinical popularization and application values.
The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solutions of the present invention can be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are within the scope of the present invention defined by the claims.
Claims (10)
1. The traditional Chinese medicine composition for treating oligospermia is characterized by comprising the following raw materials in parts by weight:
15-20 parts of semen cuscutae, 10-15 parts of semen astragali complanati, 10-15 parts of raspberry, 10-15 parts of fructus cnidii, 10-15 parts of wolfberry fruit, 10-15 parts of glossy privet fruit, 10-30 parts of schisandra chinensis, 15-30 parts of semen plantaginis, 10-15 parts of rose and 10-15 parts of lotus pistil.
2. The traditional Chinese medicine composition for treating oligoasthenospermia as claimed in claim 1, which is prepared from the following raw materials in parts by weight:
17-20 parts of semen cuscutae, 10-13 parts of semen astragali complanati, 10-13 parts of raspberry, 10-13 parts of fructus cnidii, 10-13 parts of wolfberry fruit, 10-13 parts of glossy privet fruit, 10-20 parts of schisandra chinensis, 15-23 parts of semen plantaginis, 10-15 parts of rose and 10-15 parts of lotus pistil.
3. The traditional Chinese medicine composition for treating oligoasthenospermia according to claim 1, which is characterized by comprising the following raw materials in parts by weight:
20 parts of dodder, 10 parts of flatstem milkvetch seed, 10 parts of raspberry, 10 parts of common cnidium fruit, 10 parts of medlar, 10 parts of glossy privet fruit, 10 parts of Chinese magnoliavine fruit, 20 parts of plantain seed, 10 parts of rose and 10 parts of lotus pistil.
4. The preparation method of the traditional Chinese medicine composition for treating oligoasthenospermia as claimed in any one of claims 1 to 3, which is decoction, and the specific preparation method comprises the following steps:
mixing the raw material medicines, adding water, soaking, decocting, filtering, collecting filtrate, adding water into filter residue, repeating the decocting and filtering steps, and mixing the two filtrates to obtain the Chinese medicinal decoction.
5. The preparation method of the traditional Chinese medicine composition for treating oligoasthenospermia as claimed in claim 4, wherein the soaking time is 30min;
the mass ratio of the raw materials to the water is 1;
and the mass ratio of the filter residue to the water is 1.
6. The method for preparing a Chinese medicinal composition for treating oligoasthenospermia as claimed in claim 4, wherein the decoction comprises the following steps:
decocting with strong fire to boil, and decocting with slow fire for 30min.
7. The preparation method of the traditional Chinese medicine composition for treating oligoasthenospermia as claimed in any one of claims 1 to 3, which is a pill, comprises the following steps:
heating Mel to boil for 3min, pulverizing the above materials respectively with pulverizer, mixing, adding into boiled Mel, kneading, and making into pill.
8. The method for preparing a Chinese medicinal composition for treating oligoasthenospermia according to claim 7, wherein the mixing is performed by thoroughly mixing the raw material powders in a mortar with a breast stick.
9. The preparation method of the traditional Chinese medicine composition for treating oligoasthenospermia according to claim 7, wherein the mass ratio of the raw materials to the honey is 2.5:1; the pellets weigh 2g per pellet.
10. The use of the Chinese medicinal composition for treating oligospermia according to any one of claims 1-3 in the preparation of a medicament for treating kidney essence deficiency type oligospermia in men.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116785369A (en) * | 2023-08-09 | 2023-09-22 | 安徽中医药大学 | Traditional Chinese medicine compound for treating obesity type oligospermia, preparation method and application thereof |
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| CN104173736A (en) * | 2014-06-29 | 2014-12-03 | 苟晓龙 | Kidney-tonifying sperm-growing traditional Chinese medicinal composition |
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