CN115192580A - 一种化合物在制备靶向ErbB2突变体的抑制药物中的应用 - Google Patents
一种化合物在制备靶向ErbB2突变体的抑制药物中的应用 Download PDFInfo
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- CN115192580A CN115192580A CN202210356800.1A CN202210356800A CN115192580A CN 115192580 A CN115192580 A CN 115192580A CN 202210356800 A CN202210356800 A CN 202210356800A CN 115192580 A CN115192580 A CN 115192580A
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/04—Antineoplastic agents specific for metastasis
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- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
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- Epidemiology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| CN202110358192 | 2021-04-01 | ||
| CN2021103581923 | 2021-04-01 |
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| CN115192580A true CN115192580A (zh) | 2022-10-18 |
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| EP (1) | EP4316491A4 (https=) |
| JP (1) | JP2024514098A (https=) |
| CN (1) | CN115192580A (https=) |
| WO (1) | WO2022206929A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116606289A (zh) * | 2022-02-17 | 2023-08-18 | 上海医药集团股份有限公司 | 一种含氮杂环化合物的晶型、制备方法及应用 |
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| EP4323356A1 (en) | 2021-04-13 | 2024-02-21 | Nuvalent, Inc. | Amino-substituted heterocycles for treating cancers with egfr mutations |
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| WO2007095038A2 (en) * | 2006-02-09 | 2007-08-23 | Novartis Ag | Mutations and polymorphisms of erbb2 |
| JP6791979B2 (ja) | 2016-03-01 | 2020-11-25 | シャンハイ ファーマシューティカルズ ホールディング カンパニー，リミティド | 含窒素ヘテロ環化合物、製造方法、中間体、組成物及び応用 |
| EP3677583A4 (en) * | 2017-09-01 | 2021-07-21 | Shanghai Pharmaceuticals Holding Co., Ltd. | NITROGENOUS HETEROCYCLIC COMPOUND, METHOD OF PREPARATION, INTERMEDIATE, COMPOSITION AND APPLICATION |
| EP3946293A4 (en) * | 2019-03-29 | 2023-05-03 | Board of Regents, The University of Texas System | COMPOUNDS WITH ANTITUMORIC ACTIVITIES AGAINST CANCER CELLS WITH EGFR OR HER2 EXON 20 INSERTATIONS |
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- 2022-03-31 EP EP22779109.2A patent/EP4316491A4/en active Pending
- 2022-03-31 WO PCT/CN2022/084650 patent/WO2022206929A1/zh not_active Ceased
- 2022-03-31 CN CN202210356800.1A patent/CN115192580A/zh active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116606289A (zh) * | 2022-02-17 | 2023-08-18 | 上海医药集团股份有限公司 | 一种含氮杂环化合物的晶型、制备方法及应用 |
| CN116606289B (zh) * | 2022-02-17 | 2026-02-24 | 上海医药集团股份有限公司 | 一种含氮杂环化合物的晶型、制备方法及应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4316491A4 (en) | 2025-05-07 |
| WO2022206929A1 (zh) | 2022-10-06 |
| EP4316491A1 (en) | 2024-02-07 |
| US20240197737A1 (en) | 2024-06-20 |
| JP2024514098A (ja) | 2024-03-28 |
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