CN115190791A - 高多元醇洗涤组合物 - Google Patents
高多元醇洗涤组合物 Download PDFInfo
- Publication number
- CN115190791A CN115190791A CN202180017110.7A CN202180017110A CN115190791A CN 115190791 A CN115190791 A CN 115190791A CN 202180017110 A CN202180017110 A CN 202180017110A CN 115190791 A CN115190791 A CN 115190791A
- Authority
- CN
- China
- Prior art keywords
- weight
- composition according
- cleaning composition
- composition
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 180
- 229920005862 polyol Polymers 0.000 title claims abstract description 25
- 150000003077 polyols Chemical class 0.000 title claims abstract description 25
- 239000003599 detergent Substances 0.000 title abstract description 51
- 239000004094 surface-active agent Substances 0.000 claims abstract description 18
- 239000003349 gelling agent Substances 0.000 claims abstract description 17
- 238000004140 cleaning Methods 0.000 claims description 51
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 238000005406 washing Methods 0.000 claims description 10
- 239000000679 carrageenan Substances 0.000 claims description 9
- 235000010418 carrageenan Nutrition 0.000 claims description 9
- 229920001525 carrageenan Polymers 0.000 claims description 9
- 229940113118 carrageenan Drugs 0.000 claims description 9
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 9
- 229920001615 Tragacanth Polymers 0.000 claims description 8
- 229920001282 polysaccharide Polymers 0.000 claims description 8
- 239000005017 polysaccharide Substances 0.000 claims description 8
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 8
- 235000010234 sodium benzoate Nutrition 0.000 claims description 8
- 239000004299 sodium benzoate Substances 0.000 claims description 8
- 150000004676 glycans Chemical class 0.000 claims description 7
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 6
- 241000416162 Astragalus gummifer Species 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 229940045944 sodium lauroyl glutamate Drugs 0.000 claims description 5
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 claims description 5
- 239000000196 tragacanth Substances 0.000 claims description 5
- 235000010487 tragacanth Nutrition 0.000 claims description 5
- 229940116362 tragacanth Drugs 0.000 claims description 5
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 4
- RFIMISVNSAUMBU-UHFFFAOYSA-N 2-(hydroxymethyl)-2-(prop-2-enoxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC=C RFIMISVNSAUMBU-UHFFFAOYSA-N 0.000 claims description 3
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 125000005250 alkyl acrylate group Chemical group 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 229940087068 glyceryl caprylate Drugs 0.000 claims description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 2
- 239000000845 maltitol Substances 0.000 claims description 2
- 235000010449 maltitol Nutrition 0.000 claims description 2
- 229940035436 maltitol Drugs 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 229960001855 mannitol Drugs 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical group CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 229960002920 sorbitol Drugs 0.000 claims description 2
- 235000010356 sorbitol Nutrition 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate group Chemical group C(C=C)(=O)[O-] NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 230000003020 moisturizing effect Effects 0.000 abstract description 8
- -1 D-galactose-2, 6-disulfate disaccharide Chemical class 0.000 description 42
- 239000003921 oil Substances 0.000 description 25
- 235000019198 oils Nutrition 0.000 description 25
- 239000003795 chemical substances by application Substances 0.000 description 19
- 125000000217 alkyl group Chemical group 0.000 description 14
- 239000003755 preservative agent Substances 0.000 description 12
- 239000004615 ingredient Substances 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000003945 anionic surfactant Substances 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 8
- 239000003093 cationic surfactant Substances 0.000 description 8
- 239000002736 nonionic surfactant Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 239000002253 acid Substances 0.000 description 6
- 230000002335 preservative effect Effects 0.000 description 6
- 239000002888 zwitterionic surfactant Substances 0.000 description 6
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 5
- 125000002252 acyl group Chemical group 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 229930002330 retinoic acid Natural products 0.000 description 5
- 229960001727 tretinoin Drugs 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 4
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 4
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 4
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 4
- 239000002243 precursor Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 3
- 229940079776 sodium cocoyl isethionate Drugs 0.000 description 3
- CAVXVRQDZKMZDB-UHFFFAOYSA-M sodium;2-[dodecanoyl(methyl)amino]ethanesulfonate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CCS([O-])(=O)=O CAVXVRQDZKMZDB-UHFFFAOYSA-M 0.000 description 3
- 230000003381 solubilizing effect Effects 0.000 description 3
- 230000000475 sunscreen effect Effects 0.000 description 3
- 239000000516 sunscreening agent Substances 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 150000005207 1,3-dihydroxybenzenes Chemical class 0.000 description 2
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 2
- VGMJYYDKPUPTID-UHFFFAOYSA-N 4-ethylbenzene-1,3-diol Chemical compound CCC1=CC=C(O)C=C1O VGMJYYDKPUPTID-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- 239000004288 Sodium dehydroacetate Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 239000000305 astragalus gummifer gum Substances 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- GLSRFBDXBWZNLH-UHFFFAOYSA-L disodium;2-chloroacetate;2-(4,5-dihydroimidazol-1-yl)ethanol;hydroxide Chemical compound [OH-].[Na+].[Na+].[O-]C(=O)CCl.OCCN1CCN=C1 GLSRFBDXBWZNLH-UHFFFAOYSA-L 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229940074046 glyceryl laurate Drugs 0.000 description 2
- 210000004247 hand Anatomy 0.000 description 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical class OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 2
- 239000011769 retinyl palmitate Substances 0.000 description 2
- 229940108325 retinyl palmitate Drugs 0.000 description 2
- 235000019172 retinyl palmitate Nutrition 0.000 description 2
- 229940096501 sodium cocoamphoacetate Drugs 0.000 description 2
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 2
- 229940079839 sodium dehydroacetate Drugs 0.000 description 2
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 2
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- AGGIJOLULBJGTQ-UHFFFAOYSA-N sulfoacetic acid Chemical class OC(=O)CS(O)(=O)=O AGGIJOLULBJGTQ-UHFFFAOYSA-N 0.000 description 2
- 150000003871 sulfonates Chemical class 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 238000011179 visual inspection Methods 0.000 description 2
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 description 1
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- OJISWRZIEWCUBN-QIRCYJPOSA-N (E,E,E)-geranylgeraniol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CO OJISWRZIEWCUBN-QIRCYJPOSA-N 0.000 description 1
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 description 1
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical group C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 1
- 229940031723 1,2-octanediol Drugs 0.000 description 1
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 description 1
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 description 1
- UMEKPPOFCOUEDT-UHFFFAOYSA-N 1-icosanoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO UMEKPPOFCOUEDT-UHFFFAOYSA-N 0.000 description 1
- WJDJWDHXZBNQNE-UHFFFAOYSA-M 1-octadecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 WJDJWDHXZBNQNE-UHFFFAOYSA-M 0.000 description 1
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- FUWVMBCPMRAWPG-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-hydroxyoctadecanoate Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)OCC(O)CO FUWVMBCPMRAWPG-UHFFFAOYSA-N 0.000 description 1
- GOHZKUSWWGUUNR-UHFFFAOYSA-N 2-(4,5-dihydroimidazol-1-yl)ethanol Chemical compound OCCN1CCN=C1 GOHZKUSWWGUUNR-UHFFFAOYSA-N 0.000 description 1
- AMRBZKOCOOPYNY-QXMHVHEDSA-N 2-[dimethyl-[(z)-octadec-9-enyl]azaniumyl]acetate Chemical compound CCCCCCCC\C=C/CCCCCCCC[N+](C)(C)CC([O-])=O AMRBZKOCOOPYNY-QXMHVHEDSA-N 0.000 description 1
- UTEIJFRVZOGDTH-UHFFFAOYSA-N 2-methoxyphenol;triazine Chemical compound C1=CN=NN=C1.COC1=CC=CC=C1O UTEIJFRVZOGDTH-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- ZUYVPAKYYMBQBT-UHFFFAOYSA-N 3,4-diethyl-2-hexoxyphenol Chemical compound CCCCCCOC1=C(O)C=CC(CC)=C1CC ZUYVPAKYYMBQBT-UHFFFAOYSA-N 0.000 description 1
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 1
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 description 1
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 1
- ANTLBIMVNRRJNP-UHFFFAOYSA-N 4-(2-phenylethyl)benzene-1,3-diol Chemical compound OC1=CC(O)=CC=C1CCC1=CC=CC=C1 ANTLBIMVNRRJNP-UHFFFAOYSA-N 0.000 description 1
- 239000004101 4-Hexylresorcinol Substances 0.000 description 1
- NZLWYNBRWDATJO-UHFFFAOYSA-N 4-cyclohexyl-5-methylbenzene-1,3-diol Chemical compound CC1=CC(O)=CC(O)=C1C1CCCCC1 NZLWYNBRWDATJO-UHFFFAOYSA-N 0.000 description 1
- LSEHCENPUMUIKC-UHFFFAOYSA-N 4-cyclohexylbenzene-1,3-diol Chemical compound OC1=CC(O)=CC=C1C1CCCCC1 LSEHCENPUMUIKC-UHFFFAOYSA-N 0.000 description 1
- IXMNGROEFGBSGO-UHFFFAOYSA-N 4-cyclopentylbenzene-1,3-diol Chemical compound OC1=CC(O)=CC=C1C1CCCC1 IXMNGROEFGBSGO-UHFFFAOYSA-N 0.000 description 1
- WFJIVOKAWHGMBH-UHFFFAOYSA-N 4-hexylbenzene-1,3-diol Chemical compound CCCCCCC1=CC=C(O)C=C1O WFJIVOKAWHGMBH-UHFFFAOYSA-N 0.000 description 1
- 235000019360 4-hexylresorcinol Nutrition 0.000 description 1
- NRPFNQUDKRYCNX-UHFFFAOYSA-N 4-methoxyphenylacetic acid Chemical compound COC1=CC=C(CC(O)=O)C=C1 NRPFNQUDKRYCNX-UHFFFAOYSA-N 0.000 description 1
- LNFVQIGQENWZQN-UHFFFAOYSA-N 4-propan-2-ylbenzene-1,3-diol Chemical compound CC(C)C1=CC=C(O)C=C1O LNFVQIGQENWZQN-UHFFFAOYSA-N 0.000 description 1
- FBSIDCYWGKQYRW-UHFFFAOYSA-N 5-methyl-4-propan-2-ylbenzene-1,3-diol Chemical compound CC(C)C1=C(C)C=C(O)C=C1O FBSIDCYWGKQYRW-UHFFFAOYSA-N 0.000 description 1
- MBAGLYAOSZAUFG-UHFFFAOYSA-N 6-(2,3-dihydroxypropoxy)-6-oxohexanoic acid Chemical compound OCC(O)COC(=O)CCCCC(O)=O MBAGLYAOSZAUFG-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- JBYXPOFIGCOSSB-GOJKSUSPSA-N 9-cis,11-trans-octadecadienoic acid Chemical compound CCCCCC\C=C\C=C/CCCCCCCC(O)=O JBYXPOFIGCOSSB-GOJKSUSPSA-N 0.000 description 1
- 240000000073 Achillea millefolium Species 0.000 description 1
- 235000007754 Achillea millefolium Nutrition 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- JIXAIHXJOQELOQ-UHFFFAOYSA-N CCCCCCCCCCCCCCCCCC(OC(C(C)O)=O)=O.N Chemical compound CCCCCCCCCCCCCCCCCC(OC(C(C)O)=O)=O.N JIXAIHXJOQELOQ-UHFFFAOYSA-N 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 240000004670 Glycyrrhiza echinata Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- SFRPDSKECHTFQA-ONOWFSFQSA-N [(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] propanoate Chemical compound CCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SFRPDSKECHTFQA-ONOWFSFQSA-N 0.000 description 1
- SZEJJURKOHIFBI-DPYQTVNSSA-N [(2r,3s,4s,5r)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl] hydrogen sulfate Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)[C@H](C=O)OS(O)(=O)=O SZEJJURKOHIFBI-DPYQTVNSSA-N 0.000 description 1
- OEWBEINAQKIQLZ-CMRBMDBWSA-N [(2s)-2-[(2r)-3,4-bis(2-hexyldecanoyloxy)-5-oxo-2h-furan-2-yl]-2-(2-hexyldecanoyloxy)ethyl] 2-hexyldecanoate Chemical compound CCCCCCCCC(CCCCCC)C(=O)OC[C@H](OC(=O)C(CCCCCC)CCCCCCCC)[C@H]1OC(=O)C(OC(=O)C(CCCCCC)CCCCCCCC)=C1OC(=O)C(CCCCCC)CCCCCCCC OEWBEINAQKIQLZ-CMRBMDBWSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229930002945 all-trans-retinaldehyde Natural products 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Natural products OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 229940086737 allyl sucrose Drugs 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical group 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 150000003868 ammonium compounds Chemical group 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940053195 antiepileptics hydantoin derivative Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 125000004181 carboxyalkyl group Chemical group 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-O carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O MRUAUOIMASANKQ-UHFFFAOYSA-O 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229960003993 chlorphenesin Drugs 0.000 description 1
- 229960003344 climbazole Drugs 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 229940108924 conjugated linoleic acid Drugs 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- INSRQEMEVAMETL-UHFFFAOYSA-N decane-1,1-diol Chemical compound CCCCCCCCCC(O)O INSRQEMEVAMETL-UHFFFAOYSA-N 0.000 description 1
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
- NTLIJZACUWTZFB-UHFFFAOYSA-N dimethyl-[3-(octadecanoylamino)propyl]azanium;2-hydroxypropanoate Chemical compound CC(O)C(O)=O.CCCCCCCCCCCCCCCCCC(=O)NCCCN(C)C NTLIJZACUWTZFB-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 description 1
- 229960004770 esomeprazole Drugs 0.000 description 1
- 229940100524 ethylhexylglycerin Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000007863 gel particle Substances 0.000 description 1
- XWRJRXQNOHXIOX-UHFFFAOYSA-N geranylgeraniol Natural products CC(C)=CCCC(C)=CCOCC=C(C)CCC=C(C)C XWRJRXQNOHXIOX-UHFFFAOYSA-N 0.000 description 1
- OJISWRZIEWCUBN-UHFFFAOYSA-N geranylnerol Natural products CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCO OJISWRZIEWCUBN-UHFFFAOYSA-N 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 229940049654 glyceryl behenate Drugs 0.000 description 1
- 229940080812 glyceryl caprate Drugs 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 229940087559 grape seed Drugs 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 229960003258 hexylresorcinol Drugs 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 description 1
- 229940091173 hydantoin Drugs 0.000 description 1
- 150000001469 hydantoins Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- RNYJXPUAFDFIQJ-UHFFFAOYSA-N hydron;octadecan-1-amine;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[NH3+] RNYJXPUAFDFIQJ-UHFFFAOYSA-N 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 229940075468 lauramidopropyl betaine Drugs 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940071096 lauroyl isethionate Drugs 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- CBKLICUQYUTWQL-XWGBWKJCSA-N methyl (3s,4r)-3-methyl-1-(2-phenylethyl)-4-(n-propanoylanilino)piperidine-4-carboxylate;oxalic acid Chemical compound OC(=O)C(O)=O.CCC(=O)N([C@]1([C@H](CN(CCC=2C=CC=CC=2)CC1)C)C(=O)OC)C1=CC=CC=C1 CBKLICUQYUTWQL-XWGBWKJCSA-N 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- NQMRYBIKMRVZLB-UHFFFAOYSA-N methylamine hydrochloride Chemical compound [Cl-].[NH3+]C NQMRYBIKMRVZLB-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- XRSFQLOANYRGRT-UHFFFAOYSA-N n,n-dimethyldocosan-1-amine;hydrochloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[NH+](C)C XRSFQLOANYRGRT-UHFFFAOYSA-N 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- 229960001679 octinoxate Drugs 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 229940033080 omega-6 fatty acid Drugs 0.000 description 1
- 235000020665 omega-6 fatty acid Nutrition 0.000 description 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical group [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 1
- VSXGXPNADZQTGQ-UHFFFAOYSA-N oxirane;phenol Chemical compound C1CO1.OC1=CC=CC=C1 VSXGXPNADZQTGQ-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- CNVZJPUDSLNTQU-SEYXRHQNSA-N petroselinic acid Chemical compound CCCCCCCCCCC\C=C/CCCCC(O)=O CNVZJPUDSLNTQU-SEYXRHQNSA-N 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000013502 plastic waste Substances 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 1
- LKUNXBRZDFMZOK-UHFFFAOYSA-N rac-1-monodecanoylglycerol Chemical compound CCCCCCCCCC(=O)OCC(O)CO LKUNXBRZDFMZOK-UHFFFAOYSA-N 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 235000020945 retinal Nutrition 0.000 description 1
- 239000011604 retinal Substances 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- 125000002523 retinol group Chemical group 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 235000020748 rosemary extract Nutrition 0.000 description 1
- 229940092258 rosemary extract Drugs 0.000 description 1
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 210000004378 sebocyte Anatomy 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 229940079781 sodium cocoyl glutamate Drugs 0.000 description 1
- 229940065859 sodium cocoyl glycinate Drugs 0.000 description 1
- 229940048106 sodium lauroyl isethionate Drugs 0.000 description 1
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 description 1
- HVFAVOFILADWEZ-UHFFFAOYSA-M sodium;2-[2-(dodecanoylamino)ethyl-(2-hydroxyethyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCCN(CCO)CC([O-])=O HVFAVOFILADWEZ-UHFFFAOYSA-M 0.000 description 1
- BRMSVEGRHOZCAM-UHFFFAOYSA-M sodium;2-dodecanoyloxyethanesulfonate Chemical compound [Na+].CCCCCCCCCCCC(=O)OCCS([O-])(=O)=O BRMSVEGRHOZCAM-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229940117986 sulfobetaine Drugs 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 150000005621 tetraalkylammonium salts Chemical class 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
- ZQTYRTSKQFQYPQ-UHFFFAOYSA-N trisiloxane Chemical compound [SiH3]O[SiH2]O[SiH3] ZQTYRTSKQFQYPQ-UHFFFAOYSA-N 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
本发明涉及一种稳定的、含有高多元醇的洗涤组合物。更具体地,本发明涉及一种包含多元醇、表面活性剂和胶凝剂的洗涤组合物,由此该洗涤组合物不含气穴、具有优异的保湿能力、40,000cps或更低的粘度和‑0.5至0.0的斜率。各向同性的组合物具有油状外观。
Description
技术领域
本发明涉及稳定的、含高多元醇的洗涤组合物。更具体地,本发明涉及一种包含多元醇、表面活性剂和胶凝剂的洗涤组合物,由此该洗涤组合物具有优异的保湿能力、40,000cps或更低的粘度和-0.5至0.0的斜率。令人惊讶地,含高多元醇的洗涤组合物是均匀的并且基本上不含气穴,即使在摇动或搅拌后。这种洗涤组合物也基本上不含油,但是各向同性的(isotopic),具有油状外观。
背景技术
个人护理组合物通常用于清洁皮肤并减少与称为皮脂细胞的特化上皮细胞中产生的皮脂相关的光泽。它们还用于使手和面部上的细菌最少化,使得洗涤被视为防止病菌和细菌扩散的最有效方式。事实上,专家认为全天定期洗涤可以将患感冒的消费者数量减少约50%。
消费者通常优选不仅对皮肤温和而且还向皮肤递送有益剂的组合物。这些属性诱使消费者更多地洗涤,并减少他们对过度洗涤会通过剥离皮肤的重要天然元素(包括油)而产生干燥和干裂的皮肤的担忧。另外,消费者不喜欢使用看起来和感觉粗糙的产品,而更喜欢具有吸引人的外观和天然成分的产品。
因此,本发明涉及一种稳定的、含高多元醇的洗涤组合物。所述组合物包含多元醇、表面活性剂和胶凝剂,由此所述洗涤组合物具有优异的保湿性能、40,000cps或更低的粘度和-0.5至0.0的斜率。令人惊讶的是,含高多元醇的洗涤组合物是均匀的并且基本上不含气穴,即使在摇动后。事实上,本发明的洗涤组合物易于施用和洗掉,并且具有吸引人的油状和透明或半透明外观,尽管事实上该组合物基本上不含油。
附加信息
已经公开了用于制备保湿洗涤组合物的努力。在美国专利申请号2013225693中,描述了具有阳离子表面活性剂和保湿剂的组合物。
已经描述了用于制备保湿组合物的其他努力。在GB 2330773B2中,描述了含有抗细菌剂的皮肤保湿制剂。
还描述了用于制备保湿组合物的其它努力。在美国专利号6,444,629中,描述了具有良好漂洗感和皮肤温和性的个人清洁组合物。
没有任何附加信息描述了如本文所要求保护的具有优异保湿能力的含高多元醇的洗涤组合物。
发明内容
在第一个方面中,本发明涉及一种洗涤组合物,其包含:
a)30至70%重量的多元醇;
b)0.25至6%重量的胶凝剂;
c)1.0至32%重量的表面活性剂;和
d)5至70%重量的水,
该洗涤组合物具有40,000cps或更低的粘度和-0.5至0.0的斜率,其中洗涤组合物是透明或半透明的并且基本上不含油和气穴。
在第二个方面中,本发明涉及一种洗涤组合物,其包含:
a)30至70%重量的多元醇;
b)0.25至6%重量的胶凝剂;
c)1.0至32%重量的表面活性剂;
d)0.5至5.5%重量的重量比为1:1至1:3的甘油单酯和苯甲酸钠的混合物;和
e)5至70%重量的水,
该洗涤组合物具有40,000cps或更低的粘度和-0.5至0.0的斜率,其中洗涤组合物是透明或半透明的并且基本上不含油和气穴。
在第三个方面中,本发明涉及一种用本发明的第一个或第二个方面的洗涤组合物处理皮肤的方法。
从下面的描述和实施例,本发明的所有其它方面将更容易变得显而易见。
如本文所用的,皮肤意指包括手臂(包括腋下)、面部、足部、颈部、胸部、手部、腿部、臀部和头皮(包括毛发)上的皮肤。如本文所用的含高多元醇的洗涤组合物与“洗涤组合物”同义,并且“高”意指在洗涤组合物中30%重量或更多的多元醇。摇动或搅拌包括组合物移动和振动,并且特别是与制造、填充、运输等相关的类型。本发明的洗涤组合物是透明或半透明的,并且组合物是各向同性的。基本上不含油是指基于洗涤组合物的总重量,洗涤组合物中不超过2.0%重量的油,优选不超过1.0%,且最优选0.001%至不超过0.5%重量的油。在本发明的一个实施方式中,洗涤组合物不含油(0.0%重量)。
气穴,如本文所用的,意指悬浮在本发明的各向同性洗涤组合物中的悬浮空气或空气液泡或颗粒。这种气穴是可见的,并且已知通常具有8至100微米,更通常10至90微米,甚至更通常10至75微米的直径。基本上不含气穴是指在静置3至7天,优选超过24小时至低于72小时,最优选12至24小时后,甚至在如本文所定义的摇动或搅拌后,本发明的洗涤组合物在目视检查时,基于目视评估的组合物体积,至少90%不含气穴,优选至少95%不含气穴,最优选至少99%不含气穴。因此,为避免疑义,如果洗涤组合物经视觉评估为95%不含气穴,则这意味着静止的组合物的95%体积不含任何可见的悬浮空气。油状外观是指洗涤组合物具有油基产品的外观,如包含维生素E油的产品,尽管事实上产品基本上不含油。本发明的洗涤组合物适合是洗发水、卸妆水(make-up wash)、洗面奶或个人护理液体沐浴露。优选地,本发明的洗涤组合物是沐浴露,其准备用于局部施用并且待擦拭或洗掉,并且优选用水洗掉。洗涤组合物可任选地包含药物或治疗剂,但优选地,是美容和非治疗性洗涤的洗剂。在本发明的一个实施方式中,洗涤组合物是特别适用于婴儿的个人洗涤组合物。如下文所述,本发明的洗涤组合物可任选地包含加入其中的皮肤有益成分,如维生素和/或其衍生物、间苯二酚类、视黄酸前体、着色剂、保湿剂、防晒剂、其混合物等。皮肤有益成分(或试剂)可以是水溶性或油溶性的。如果使用,油溶性皮肤有益剂通常占洗涤组合物重量的至多1.0%,而水溶性皮肤有益剂在使用时通常占洗涤组合物重量的至多10%。洗涤组合物通常具有4.8至7.5,优选5至7.5,最优选6.0至7.5的pH。在本发明的一个实施方式中,洗涤组合物的pH可以是6.3至7.2,包括其中包含的所有范围。除非另有说明,粘度是用DiscoveryHR-2流变仪使用具有1000微米间隙的喷砂板获得的,和对于第一粘度VA的第一剪切速率SA为0.1s-1和对于第二粘度VB的第二剪切速率SB为10s-1,均在25℃和20秒间隔下。如本文所用的斜率被定义为[Log(VB)-Log(VA)]/[Log(SB)-Log(SA)]。粘度以帕斯卡秒(1帕斯卡秒=1000厘泊(cps))来记录。如本文所用的稳定是指在45℃下储存至少一(1)个月,优选在45℃下储存2-4个月后,洗涤组合物没有变色或相分离。术语“包含”是指包括术语“基本上由……组成”和“由……组成”。为避免疑义,且为了说明,本发明的包含表面活性剂、水和多元醇的组合物是指包括基本上由其组成的组合物和由其组成的组合物。
除了在操作比较例中,或另外明确指出的情况下,否则本说明书中表示材料或条件的量或比率和/或材料的物理性质和/或用途的所有数字应理解为由词语“约”修饰。本文定义的所有范围意在包括其中包含的所有范围,除非另有说明。
具体实施方式
适用于本发明的多元醇仅限于其适用于局部组合物和是水溶性的程度。适用于本发明的多元醇的说明性和非限制性实例包括山梨糖醇、甘油、甘露糖醇、木糖醇、麦芽糖醇或其混合物。在本发明的一个实施方式中,基于洗涤组合物中使用的多元醇的总重量,使用的多元醇为至少50%重量的甘油。在本发明的另一个实施方式中,使用的多元醇是全甘油(100%重量)。多元醇通常占洗涤组合物的30至70%重量,优选占洗涤组合物的35至65%重量,最优选占洗涤组合物的45至55%重量,包括其中包含的所有范围。
关于本发明中使用的胶凝剂,其仅限于可用于局部施用于消费者的组合物中并且适用于产生具有如本文所定义的粘度和斜率的洗涤组合物的程度。适用于本发明的胶凝剂类型的说明性但非限制性的实例是归类为糖类、丙烯酸酯、其混合物或其衍生物的那些。关于多糖,这些包括角叉菜胶,以及依据名称黄蓍胶(Traganth Gum)销售的支链多糖,其中后者是由黄蓍酸和黄蓍胶糖(bassorin)组成的支链多糖。黄蓍胶(约35%)是水溶性多糖,并且主要级分黄蓍胶糖(约65%)含有甲基醚基团并在水中溶胀,从而保持水不溶性并形成凝胶颗粒。此类黄蓍胶可从供应商(如ISC Gums)以名称Tragacanth T-40E商购获得。关于适用的丙烯酸酯,这些包括与烯丙基蔗糖或烯丙基季戊四醇丙烯酸交联的丙烯酸以及与烯丙基季戊四醇交联的C10-C30烷基丙烯酸酯。这样的丙烯酸酯以名称出售,并且可由Lubrizol商购获得。
适用的其它丙烯酸酯包括作为由丙烯酸和乙氧基化棕榈醇的酯与约25摩尔环氧乙烷的酯和丙烯酸、甲基丙烯酸或它们的简单酯之一的一种或多种单体形成的共聚物。这些丙烯酸酯例如以Synthalen名称出售,并且可从供应商(如3V)商购获得。
在本发明的一个实施方式中,多糖是角叉菜胶,并且在另一个实施方式中,多糖是λ角叉菜胶(D-半乳糖-2-硫酸酯和D-半乳糖-2,6-二硫酸酯二糖)。在本发明的又一个实施方式中,基于洗涤组合物中胶凝剂的总重量,至少50%,且优选至少75%,且最优选至少90%重量的胶凝剂是λ角叉菜胶。在本发明的优选实施方式中,胶凝剂是作为天然衍生的,并且基于洗涤组合物中胶凝剂的总重量,是至少95%重量的λ角叉菜胶,优选100%重量的λ角叉菜胶(可从供应商如CP Kelco商购获得)的胶凝剂。通常,胶凝剂占洗涤组合物的0.25至6%,优选0.35至4%,最优选0.5%至2.5%重量,包括其中包含的所有范围。
任选地,但通常优选地,甘油单酯与防腐剂和任选地苯甲酸钠一起用于本发明的洗涤组合物中。适用于本发明的示例性甘油单酯包括月桂酸甘油酯、月桂酸/油酸甘油酯、己二酸甘油酯、藻酸甘油酯、花生酸甘油酯、山嵛酸甘油酯、癸酸甘油酯、辛酸甘油酯、羟基硬脂酸甘油酯,其混合物等。使用时,这类单酯占洗涤组合物的0.1至1.0%,且优选0.2至0.8%,且最优选0.3至0.7%重量,并且包括其中包含的所有范围。当苯甲酸钠任选地与甘油单酯一起使用时,其通常占洗涤组合物的0.4至3%,优选0.5至2.5%重量,最优选0.6至1.5%重量,包括其中包含的所有范围。在本发明的一个实施方式中,甘油单酯与苯甲酸钠的重量比为1:1至1:3,且优选1:1至1:2.5,且最优选1:1至1:2,包括其中包含的所有重量比。
本发明的洗涤组合物的粘度(在0.1/s下测量20秒)为40,000cps或更低,优选1,500至30,000cps,最优选3,000至20,000cps,包括其中包含的所有范围。洗涤组合物的斜率为-0.5至0.0,优选-0.4至0.0,最优选-0.3至0.0,包括其中包含的所有范围。粘度在25℃下测量。
关于适用于本发明的洗涤组合物中的阴离子表面活性剂,所用的阴离子表面活性剂可包括脂族磺酸盐,如伯烷烃(例如C8-C22)磺酸盐、伯烷烃(例如C8-C22)二磺酸盐、C8-C22烯烃磺酸盐、C8-C22羟基烷烃磺酸盐或烷基甘油醚磺酸盐(AGS);或芳族磺酸盐,如烷基苯磺酸盐。阴离子表面活性剂还可以是烷基硫酸盐(例如C12-C18烷基硫酸盐)或烷基醚硫酸盐(包括烷基甘油基醚硫酸盐)。其中烷基醚硫酸盐是具有下式的那些:
RO(CH2CH2O)nSO3M
其中R是具有8至18个碳,优选12至18个碳的烷基或烯基,n具有至少1.0,优选小于5,且最优选1至4的平均值,并且M是增溶阳离子,如钠、钾、铵或取代的铵。
阴离子表面活性剂还可包括烷基磺基琥珀酸盐(包括单烷基和二烷基,例如C6-C22磺基琥珀酸盐);烷基和酰基牛磺酸盐(通常为甲基牛磺酸盐)、烷基和酰基肌氨酸盐、磺基乙酸盐、C8-C22烷基磷酸盐和膦酸盐、烷基磷酸酯和烷氧基烷基磷酸酯、酰基乳酸盐、C8-C22单烷基琥珀酸盐和马来酸盐、磺基乙酸盐、烷基葡糖苷和酰基羟乙磺酸盐等。
磺基琥珀酸盐可以是具有下式的单烷基磺基琥珀酸盐:
R1O2CCH2CH(SO3M)CO2M;
和下式的酰胺-MEA磺基琥珀酸盐:
R1CONHCH2CH2O2CCH2CH(SO3M)CO2M,其中R1范围为C8-C22烷基。
肌氨酸盐通常由下式表示:
R2CON(CH3)CH2CO2M,其中R2范围为C8-C20烷基。
牛磺酸盐通常由下式表示:
R3CONR4CH2CH2SO3M,
其中R3是C8-C20烷基,R4是C1-C4烷基。
M是如前所述的增溶阳离子。可以使用的羟乙基磺酸盐包括C8-C18酰基羟乙基磺酸盐(包括具有取代的头部基团(如C1-4烷基取代,优选甲基取代)的那些)。这些酯通过碱金属羟乙基磺酸盐与具有6至18个碳原子且碘值小于20的混合脂族脂肪酸之间的反应来制备。通常至少75%的混合脂肪酸具有12至18个碳原子,并且至多25%具有6至10个碳原子。
适合使用的酰基羟乙基磺酸盐可以是烷氧基化的羟乙基磺酸盐,如在1995年2月28日授权的名称为“聚烷氧基化羟乙基酸的脂肪酸酯”的Llardi等的美国专利号5,393,466中所述的;在此引入作为参考。这种化合物具有通式:
R5C--O(O)--C(X)H--C(Y)H--(OCH2--CH2)m--SO3M
其中R5是具有8至18个碳的烷基,m是1至4的整数,X和Y各自独立地是氢或具有1至4个碳的烷基,并且M是如前所述的增溶阳离子。
在本发明的一个实施方式中,适合使用的阴离子表面活性剂是月桂酰甘氨酸钠、椰油酰甘氨酸钠、月桂酰谷氨酸钠、椰油酰谷氨酸钠、月桂酰羟乙基磺酸钠、椰油酰羟乙基磺酸钠、甲基月桂酰牛磺酸钠、甲基椰油酰牛磺酸钠或其混合物。此类阴离子表面活性剂可从供应商如Galaxy Surfactants、Clariant、Sino Lion和Innospec商购获得。椰油酰基羟乙基磺酸钠、甲基月桂酰基牛磺酸钠、月桂酰基葡糖酸钠、甲基月桂酰基羟乙基磺酸钠或其混合物是优选的适合使用的阴离子表面活性剂。在本发明的一个实施方式中,使用的阴离子表面活性剂通常为月桂酰谷氨酸钠、椰油酰羟乙基磺酸钠和/或甲基月桂酰牛磺酸钠中的至少一种。在优选实施方式中,本发明的洗涤组合物中使用的阴离子表面活性剂是月桂酰谷氨酸钠。
适用于本发明的两性表面活性剂(取决于pH,其可以是两性离子的)包括酰基两性乙酸钠、酰基两性丙酸钠、酰基两性二乙酸二钠和酰基两性二丙酸二钠,其中酰基(即烷酰基)可以包含C7-C18烷基部分。适合使用的两性表面活性剂的说明性实例包括月桂酰两性乙酸钠、椰油酰两性乙酸钠、月桂酰两性基乙酸钠、椰油酰两性基乙酸钠或其混合物。
关于可用于本发明的洗涤组合物中的两性离子表面活性剂,此类表面活性剂包括至少一个酸基团。这样的酸基团可以是羧酸或磺酸基团。它们通常包括季氮,且因此可以是季氨基酸。它们通常应包括7至18个碳原子的烷基或烯基,通常符合总体结构式:R6--[--C(O)--NH(CH2)q--]r--N+--(R7--)(R8)A--B,其中R7是7-18个碳原子的烷基或烯基;R7和R8各自独立地为具有1至3个碳原子的烷基、羟烷基或羧基烷基;q为2至4;r为0至1;A是任选地被羟基取代的1至3个碳原子的亚烷基,并且B是--CO2--或--SO3--。
可用于本发明并在上述通式内的合适的两性离子表面活性剂包括下式的简单甜菜碱:
R6--N+--(R7)(R8)CH2CO2 -
和下式的酰胺基甜菜碱:
R6--CONH(CH2)t--N+--(R7)(R8)CH2CO2 -,其中t是2或3。
在两个式中,R6、R7和R8如前定义。特别地,R6可以是源自椰子油的C12和C14烷基的混合物,使得至少一半,优选至少四分之三的基团R6具有10至14个碳原子。R7和R8优选是甲基。
另一种可能性是两性离子表面活性剂是下式的磺基甜菜碱:
R6--N+--(R7)(R8)(CH2)3SO3 -
或
R6--CONH(CH2)u--N+--(R7)(R8)(CH2)3SO3 -
其中u是2或3,或这些的变体,其中--(CH2)3SO3 -替换为-CH2C(OH)(H)CH2SO3 -。
在这些式中,R6、R7和R8如前定义。
适合使用的两性离子表面活性剂的说明性实例包括甜菜碱,如椰油二甲基羧甲基甜菜碱、椰油酰胺丙基甜菜碱和月桂酰胺丙基甜菜碱。适合使用的其他两性离子表面活性剂包括椰油酰胺丙基磺基甜菜碱(sultaine)。此类表面活性剂可从供应商如Stepan公司商购获得,并且使用上述表面活性剂的混合物在本发明的范围内。在优选实施方式中,本发明洗涤中使用的两性离子表面活性剂是椰油酰胺丙基甜菜碱。在又一个实施方式中,椰油酰胺丙基甜菜碱与月桂酰谷氨酸钠以1:1至1:5的重量比,优选以1:1.1至1:4的比率,和优选以1:1.2至1:3.5的比率使用,包括其中所包含的所有重量比。
非离子表面活性剂可用于本发明的洗涤组合物中。使用时,非离子表面活性剂通常以低至洗涤组合物的0.5、1、1.5或2%重量的水平和高至6、8、10或12%重量的水平使用。可以使用的非离子表面活性剂特别包括具有疏水基团和反应性氢原子的化合物(例如脂族醇、酸、酰胺或烷基酚)与环氧烷(特别是单独的环氧乙烷或环氧乙烷与环氧丙烷)的反应产物。具体的非离子表面活性剂化合物是烷基(C6-C22)酚环氧乙烷缩合物,脂族(C8-C18)伯或仲直链或支链醇与环氧乙烷的缩合产物,以及通过环氧乙烷与环氧丙烷和乙二胺的反应产物的缩合制备的产物。其它非离子表面活性剂包括长链叔胺氧化物、长链叔膦氧化物、二烷基亚砜等。
在本发明的实施方式中,任选使用的非离子表面活性剂可包括具有以下结构的脂肪酸/醇乙氧基化物:a)HOCH2(CH2)s(CH2CH2O)v或b)HOOC(CH2)c(CH2CH2O)dH;其中s和v各自独立地为至多18的整数;并且c和d各自独立地为1或更大的整数。在本发明的实施方式中,s和v各自独立地为6至18;c和d各自独立地为1至30。非离子表面活性剂的其它选项包括具有下式的那些:HOOC(CH2)i-CH=CH--(CH2)k(CH2CH2O)zH,其中i、k各自独立地为5至15;并且z为5至50。在本发明的另一个实施方式中,i和k各自独立地为6至12;并且z为15至35。
非离子表面活性剂还可以包括糖酰胺,如多糖酰胺。具体地,表面活性剂可以是在1995年2月14日授权的名称为“包含非离子糖脂表面活性剂的组合物”的Au等的美国专利号5,389,279中描述的乳糖酰胺(lactobionamide)之一;在此将其引入作为参考,或者它可以是在1991年4月23日授权的名称为“N-多羟基烷基脂肪酸酰胺作为液体水性表面活性剂体系的增稠剂”的Kelkenberg的美国专利号5,009,814中描述的糖酰胺之一;在此将其引入本申请中作为参考。
在本发明的实施方式中,阳离子表面活性剂可任选地用于本发明的洗涤组合物中。
一类任选的阳离子表面活性剂包括杂环铵盐,如十六烷基或硬脂基氯化吡啶、烷基酰胺乙基吡咯啉(pyrrylinodium)甲基硫酸盐和拉匹氯铵(lapyrium chloride)。
四烷基铵盐是另一类适用于任选用途的阳离子表面活性剂。实例包括鲸蜡基或硬脂酰三甲基氯化铵或溴化铵;氢化棕榈或牛脂三甲基卤化铵;山嵛基三甲基铵卤化物或甲基硫酸盐;癸基异壬基二甲基卤化铵;二牛脂(或二硬脂酰)二甲基卤化铵和山嵛基二甲基氯化铵。
可以使用的其它类型的阳离子表面活性剂是各种乙氧基化季胺和酯季铵盐。实例包括PEG-5硬脂酰乳酸铵(例如,由Clariant制造的Genamin KSL)、PEG-2椰油基氯化铵、PEG-15氢化牛脂氯化铵、PEG 15硬脂酰氯化铵、二棕榈酰乙基甲基氯化铵、二棕榈酰羟乙基甲基硫酸盐和硬脂酰胺丙基二甲胺乳酸盐。
适用于任选用途的更多其它有用的阳离子表面活性剂包括丝、小麦和角蛋白蛋白质的季铵化水解产物,并且使用上述阳离子表面活性剂的混合物也在本发明的范围内。
如果使用,阳离子表面活性剂将占洗涤组合物的不超过1.0重量%。存在时,它们通常占洗涤组合物的0.01至0.7%,且更通常0.1至0.5%重量,包括其中包含的所有范围。
在本发明的实施方式中,本发明的洗涤组合物将基本上不含聚合季铵化合物(包括其盐)。在另一个实施方式中,洗涤组合物将包含小于0.1%重量的聚季铵化合物。在又一个实施方式中,洗涤组合物包含小于0.01%重量的聚合季铵化合物。在甚至另一个实施方式中,洗涤组合物不含聚合季铵化合物(即0.0%)。
水通常占洗涤组合物的5至70%重量,优选20至60%重量,且最优选25至55%重量,包括其中包含的所有范围。
可以使用适于调节/缓冲pH的调节剂。这类pH调节剂包括三乙胺、NaOH、KOH、H2SO4、HCl、C6H8O7(即柠檬酸)或其混合物。pH调节剂以产生所需最终pH的量加入。pH值可以用商业仪器评估,如可从Thermo公司商购获得的pH计。
适用于本发明的洗涤组合物的任选皮肤有益剂仅限于它们能够局部施用,并且适于在所需pH下溶解在洗涤组合物中的程度。
适合包含在洗涤组合物的水部分中的有益剂的说明性实例是酸,如氨基酸,如精氨酸、缬氨酸或组氨酸。适用的其他水溶性有益剂包括维生素B2、烟酰胺(维生素B3)、维生素B6、维生素C、及其混合物等。也可以使用这些维生素的水溶性衍生物。例如,维生素C衍生物,如抗坏血酸四异棕榈酸酯、抗坏血酸磷酸镁和抗坏血酸糖苷,可以单独使用或彼此组合使用。适用的其它水溶性有益剂包括4-乙基间苯二酚、提取物如鼠尾草、芦荟、绿茶、葡萄籽、百里香、洋甘菊、蓍草、黄瓜、甘草、迷迭香提取物或其混合物。也可以使用水溶性防晒剂,如恩索利唑。当存在于本发明中时,任选的水溶性有益剂(包括混合物)的总量,基于洗涤组合物的总重量,可在0.0至10%,优选0.001至8%,并且最优选0.01至6%重量的范围内,并且包括其中包含的所有范围。
任选地包括油(即非水)溶性有益剂也在本发明的范围内。再次,洗涤组合物基本上不含油,并且优选不含油(0.0%),其中油不意味着包括从芳香剂添加的任何油。因此,油溶性活性物质或有益剂溶解在所用的表面活性剂中。关于此类油溶性有益剂的唯一限制是在局部施用时,其适于提供益处。
可任选地用于本发明的组合物中的油溶性有益剂类型的说明性示例包括以下组分:如硬脂酸、维生素如维生素A、D、E和K(及其油溶性衍生物)、防晒剂如乙基己基甲氧基肉桂酸酯、双乙基己氧基苯酚甲氧基苯酚三嗪、2-乙基己基-2-氰基-3,3-二苯基-2-丙酸、甲酚曲唑三硅氧烷、3,3,5-三甲基环己基2-羟基苯甲酸酯、2-乙基己基-2-羟基苯甲酸酯或其混合物。
适用的其它任选的油溶性有益剂包括间苯二酚类,如4-己基间苯二酚、4-苯乙基间苯二酚、4-环戊基间苯二酚、4-环己基间苯二酚、4-异丙基间苯二酚或其混合物。此外,可以使用5-取代的间苯二酚类,如4-环己基-5-甲基苯-1,3-二醇、4-异丙基-5-甲基苯-1,3-二醇、其混合物等。5-取代的间苯二酚类及其合成描述于共同受让的美国公开专利申请No.2016/0000669A1中。
适用的更多其它油溶性活性物质包括ω-3脂肪酸、ω-6脂肪酸、氯咪巴唑、法呢醇、熊果酸、肉豆蔻酸、香叶基香叶醇、油基甜菜碱、椰油酰羟乙基咪唑啉、己酰基鞘氨醇、12-羟基硬脂酸、岩芹酸、共轭亚油酸、萜品醇、百里酚,其混合物等。
在本发明的一个实施方式中,所用的任选的油溶性有益剂是视黄酸前体。在本发明的一个实施方式中,视黄酸前体是视黄醇、视黄醛、视黄醇丙酸酯、视黄醇棕榈酸酯、视黄醇乙酸酯或其混合物。视黄醇丙酸酯、视黄醇棕榈酸酯及其混合物通常是优选的。
适用的再另一种视黄酸前体是由Molecular Design International提供的以名称市售可得的对甲氧基苯基氧代乙醇(hydroxyanasatil)视黄酸酯。其可以在与本文所述的油溶性活性物质的混合物中使用。
在本发明的组合物中使用任选的油溶性活性物质时,这种活性物质通常占洗涤组合物重量的0.0至0.75%,和优选0.001至5%,且最优选0.05至0.35%。在又一个实施方式中,油占洗涤组合物总重量的0.1至0.5%重量,包括其中包含的所有范围,并且排除由芳香剂提供的任何油。
除了使用如前所述的苯甲酸钠与甘油单酯外,可能期望将常规防腐剂掺入洗涤组合物中以防止潜在有害微生物的生长。化妆品化学家熟悉合适的防腐剂,并且通常选择它们以满足防腐剂挑战测试并提供产品稳定性。适用的传统防腐剂包括乙内酰脲衍生物和丙酸盐。特别优选的防腐剂是碘代丙炔基丁基氨基甲酸酯、苯氧基乙醇、1,2-辛二醇、羟基苯乙酮、乙基己基甘油、己二醇、对羟基苯甲酸甲酯、对羟基苯甲酸丙酯、咪唑烷基脲、脱氢乙酸钠、二甲基-二甲基(DMDM)乙内酰脲和苄醇,及其混合物。适用的其它防腐剂包括脱氢乙酸钠、氯苯甘油醚和癸二醇。防腐剂的选择应考虑到组合物的用途以及防腐剂与乳液中其他成分之间可能的不相容性。防腐剂优选以洗涤组合物总重量的0.01%至2.0%重量的量使用,包括其中包含的所有范围。还优选的是具有单独的羟基苯乙酮或与其他防腐剂的混合物的防腐剂体系。
芳香剂、固定剂、螯合剂(如EDTA)和去角质剂可任选地包括在本发明的洗涤组合物中。这些物质中的每一种可以在洗涤组合物总重量的约0.03至约5%,优选0.1至3%重量的范围内,包括其中包含的所有范围。就使用剥离剂而言,选择的那些应具有足够小的粒度,使得它们不影响用于分配本发明组合物的任何包装的性能。
可任选使用HLB大于8的常规乳化剂。说明性实例包括吐温40、60、80,聚山梨醇酯20及其混合物。通常,用于水连续体系的乳化剂占洗涤组合物的0.03至1.5%重量。
关于本发明的洗涤组合物,基于洗涤组合物的总重,其通常具有1至32%,优选2至20%,且最优选3%至12%重量的总表面活性剂,并且包括其中包含的所有范围。在本发明的实施方式中,洗涤组合物包含基于洗涤组合物总重量的7至11%重量的总表面活性剂,并且包括其中包含的所有范围。
制备本发明的洗涤组合物时,所需成分可以用常规设备在中等剪切和大气条件下混合,温度为30至85℃,由此剪切持续直至回收均匀产物。
用于洗涤组合物的包装通常不受限制,只要组合物可以分配即可。在本发明的实施方式中,洗涤组合物以袋、瓶、广口瓶、管或罐出售。包装优选地允许无限次再填充,以始终减少环境中的塑料废物。
提供实施例以利于理解本发明。它们不旨在限制权利要求的范围。
实施例中的所有样品通过在中等剪切下并且在约80℃的温度和大气压的压力下混合成分来制备。
实施例1比较样品
a-70%水,3%氯化钠和次要成分
b-65%水,4.5%氯化钠和次要成分
c-15%水和次要成分
d-9%水和次要成分
e-Pa*s×1000=厘泊(CPS)
ND-不可测定,配方不稳定
样品1-6的洗涤组合物的粘度和斜率反映出其不是按照本发明制备的。此外,组合物不是半透明或透明的,并且在生产和填充到玻璃罐中之后具有非常明显的气穴迹象。将组合物重度充气,并且在约24小时后,空气没有消散。将这些样品的组成呈现给熟练的专家小组成员,并且没有人得出样品具有油状外观的结论。
实施例2本发明样品
a-70%水,3%氯化钠和次要物质
b-65%水,4.5%氯化钠和次要物质
e-PA*s×1000=厘泊(CPS)
样品7至15中制备的组合物具有反映出其按照本发明制备的粘度和斜率。
在制备后,样品的洗涤组合物是透明的并且基本上不含(在目视检查之后)气穴。
在移动组合物并填充玻璃广口瓶后,洗涤组合物具有气穴的视觉迹象,其在约24小时内几乎完全消散。此外,本领域技术人员观察样品7至15的组成,并且都得出结论,组合物具有油状外观,尽管事实上它们配制成不含油。
实施例3
ND-不可测定,配方不稳定。数据表明在溶剂中胶凝剂产生的斜率值不指示洗涤组合物的性能,证实本发明的洗涤组合物出乎意料地优异,因为它们基本上不含气穴,并且即使在不含油配制时也具有油状外观。
Claims (15)
1.一种洗涤组合物,其包含:
a)30至70%重量的多元醇;
b)0.25至6%重量的胶凝剂;
c)1.0至32%重量的表面活性剂;
d)5至70%重量的水,
其中所述洗涤组合物基本上不含油。
2.根据权利要求1所述的洗涤组合物,其中所述组合物还包含甘油单酯。
3.根据前述任一项权利要求所述的洗涤组合物,其中所述组合物还包含苯甲酸钠。
4.根据前述任一项权利要求所述的洗涤组合物,其中所述组合物包含0.5至5.0%重量的重量比为1:1至1:3的甘油单酯和苯甲酸钠的混合物。
5.根据前述任一项权利要求所述的洗涤组合物,其具有40,000cps或更小的粘度和-0.5至0.0的斜率。
6.根据前述任一项权利要求所述的洗涤组合物,其中所述多元醇是山梨糖醇、甘油、甘露糖醇、木糖醇、麦芽糖醇或其混合物。
7.根据前述任一项权利要求所述的洗涤组合物,其中所述胶凝剂是丙烯酸酯、多糖或其混合物。
8.根据前述任一项权利要求所述的洗涤组合物,其中所述胶凝剂是黄蓍胶、λ角叉菜胶、与烯丙基季戊四醇交联的C10-C30烷基丙烯酸酯或其混合物。
9.根据前述任一项权利要求所述的洗涤组合物,其中所述胶凝剂是λ角叉菜胶,并且所述多元醇是甘油,并且进一步其中λ角叉菜胶以0.35至4%重量的量存在,并且所述甘油以35至65%重量的量存在。
10.根据前述任一项权利要求所述的洗涤组合物,其中所述表面活性剂是1:1至1:5重量比的椰油酰胺丙基甜菜碱和月桂酰谷氨酸钠的混合物。
11.根据前述任一项权利要求所述的洗涤组合物,其中所述洗涤组合物基本上不含油和气穴。
12.根据前述任一项权利要求所述的洗涤组合物,其中所述洗涤组合物是各向同性的。
13.根据前述任一项权利要求所述的洗涤组合物,其中所述组合物包含0.5至5.5%重量的重量比为1:1至1:2.5的甘油单酯和苯甲酸钠的混合物,35至65%重量的水,并且具有3,000cps至20,000cps的粘度。
14.根据前述任一项权利要求所述的洗涤组合物,其中所述甘油单酯是辛酸甘油酯。
15.一种用于处理皮肤的方法,包括以下步骤:使需要洗涤的皮肤与根据前述任一项权利要求所述的组合物接触,和用水洗掉所述组合物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/804,856 US11382847B2 (en) | 2020-02-28 | 2020-02-28 | High polyol wash composition |
US16/804,856 | 2020-02-28 | ||
EP20167781 | 2020-04-02 | ||
EP20167781.2 | 2020-04-02 | ||
PCT/EP2021/054886 WO2021170828A1 (en) | 2020-02-28 | 2021-02-26 | High polyol wash composition |
Publications (1)
Publication Number | Publication Date |
---|---|
CN115190791A true CN115190791A (zh) | 2022-10-14 |
Family
ID=74732948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202180017110.7A Pending CN115190791A (zh) | 2020-02-28 | 2021-02-26 | 高多元醇洗涤组合物 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20230149273A1 (zh) |
EP (1) | EP4110274B1 (zh) |
CN (1) | CN115190791A (zh) |
BR (1) | BR112022016161A2 (zh) |
MX (1) | MX2022010563A (zh) |
WO (1) | WO2021170828A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024056586A2 (en) * | 2022-09-16 | 2024-03-21 | Unilever Ip Holdings B.V. | Self-foaming cleansing composition |
WO2024056587A1 (en) * | 2022-09-16 | 2024-03-21 | Unilever Ip Holdings B.V. | Self-foaming cleansing composition |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101065098A (zh) * | 2004-07-29 | 2007-10-31 | 荷兰联合利华有限公司 | 包含底层带有阳离子电荷的非硅酸盐的基本不含酶的个人洗涤组合物 |
CN101160154A (zh) * | 2005-02-16 | 2008-04-09 | 荷兰联合利华有限公司 | 具有独特感官性质的液体清洁组合物 |
CN101505720A (zh) * | 2006-08-29 | 2009-08-12 | 花王株式会社 | 凝胶状化妆品 |
CN103379895A (zh) * | 2010-12-06 | 2013-10-30 | 荷兰联合利华有限公司 | 包含脂肪酰基羟乙基磺酸盐表面活性剂产品、烷酰基化合物和具有低水平氢化的甘油三酸酯的组合物 |
US20160089314A1 (en) * | 2014-09-30 | 2016-03-31 | The Procter & Gamble Company | Stable lotion emulsion composition and wet wipe |
KR20180133170A (ko) * | 2017-06-05 | 2018-12-13 | 주식회사 엘지생활건강 | 오일 고함유 세정제의 거품력을 향상시킨 클렌징 화장료 조성물 |
WO2019011521A1 (en) * | 2017-07-10 | 2019-01-17 | Unilever Plc | HIGH GLYCEROL COMPOSITION COMPRISING MIXTURES OF ALKYL ISETHIONATE AND ALKYL TAURATE |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3711776A1 (de) | 1987-04-08 | 1988-10-27 | Huels Chemische Werke Ag | Verwendung von n-polyhydroxyalkylfettsaeureamiden als verdickungsmittel fuer fluessige waessrige tensidsysteme |
DE69214402T2 (de) | 1991-11-25 | 1997-03-20 | Unilever Nv | Fettsäureester von alkoxylierter Isethionsäure und sie enthaltende Reinigungsmittelzusammensetzungen |
US5389279A (en) | 1991-12-31 | 1995-02-14 | Lever Brothers Company, Division Of Conopco, Inc. | Compositions comprising nonionic glycolipid surfactants |
US6444629B1 (en) | 1997-08-22 | 2002-09-03 | The Procter & Gamble Company | Cleansing compositions |
GB9723068D0 (en) | 1997-10-31 | 1998-01-07 | Patel Atulkumar S | A skin-moisturing preparation |
DE102004017369A1 (de) * | 2004-04-08 | 2005-11-03 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Screeningverfahren zur Identifizierung von PUFA-PKS in Proben |
GB2421432A (en) * | 2004-12-23 | 2006-06-28 | Cosmetic Warriors Ltd | Cosmetic jelly |
MX355430B (es) | 2013-03-08 | 2018-04-18 | Unilever Nv | Compuestos de resorcinol para uso dermatologico. |
WO2018075833A1 (en) * | 2016-10-21 | 2018-04-26 | The Procter & Gamble Company | Low viscosity hair care composition |
DE102016221851A1 (de) * | 2016-11-08 | 2018-05-09 | Henkel Ag & Co. Kgaa | Amylase für Wasch- und Reinigungsmittelanwendungen |
US11382847B2 (en) * | 2020-02-28 | 2022-07-12 | Conopco, Inc. | High polyol wash composition |
-
2021
- 2021-02-26 EP EP21707998.7A patent/EP4110274B1/en active Active
- 2021-02-26 US US17/802,314 patent/US20230149273A1/en active Pending
- 2021-02-26 CN CN202180017110.7A patent/CN115190791A/zh active Pending
- 2021-02-26 BR BR112022016161A patent/BR112022016161A2/pt unknown
- 2021-02-26 MX MX2022010563A patent/MX2022010563A/es unknown
- 2021-02-26 WO PCT/EP2021/054886 patent/WO2021170828A1/en active Search and Examination
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101065098A (zh) * | 2004-07-29 | 2007-10-31 | 荷兰联合利华有限公司 | 包含底层带有阳离子电荷的非硅酸盐的基本不含酶的个人洗涤组合物 |
CN101160154A (zh) * | 2005-02-16 | 2008-04-09 | 荷兰联合利华有限公司 | 具有独特感官性质的液体清洁组合物 |
CN101505720A (zh) * | 2006-08-29 | 2009-08-12 | 花王株式会社 | 凝胶状化妆品 |
CN103379895A (zh) * | 2010-12-06 | 2013-10-30 | 荷兰联合利华有限公司 | 包含脂肪酰基羟乙基磺酸盐表面活性剂产品、烷酰基化合物和具有低水平氢化的甘油三酸酯的组合物 |
US20160089314A1 (en) * | 2014-09-30 | 2016-03-31 | The Procter & Gamble Company | Stable lotion emulsion composition and wet wipe |
KR20180133170A (ko) * | 2017-06-05 | 2018-12-13 | 주식회사 엘지생활건강 | 오일 고함유 세정제의 거품력을 향상시킨 클렌징 화장료 조성물 |
WO2019011521A1 (en) * | 2017-07-10 | 2019-01-17 | Unilever Plc | HIGH GLYCEROL COMPOSITION COMPRISING MIXTURES OF ALKYL ISETHIONATE AND ALKYL TAURATE |
Also Published As
Publication number | Publication date |
---|---|
EP4110274A1 (en) | 2023-01-04 |
EP4110274B1 (en) | 2023-08-09 |
WO2021170828A1 (en) | 2021-09-02 |
US20230149273A1 (en) | 2023-05-18 |
BR112022016161A2 (pt) | 2022-10-04 |
MX2022010563A (es) | 2022-09-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2850039C (en) | Shampoo composition containing a gel network | |
EP2211830B1 (en) | Personal care composition | |
CN102971050A (zh) | 脂肪酰基甘氨酸盐表面活性剂的泡沫增强 | |
EA017704B1 (ru) | Содержащие продукт в виде жирного ацилизетионата жидкие очищающие композиции, стабилизированные смесью длинноцепочечных и короткоцепочечных жирных кислот/жирных мыл | |
CN115190791A (zh) | 高多元醇洗涤组合物 | |
US11904035B2 (en) | Lamellar liquid cleansers comprising acyl isethionate and methyl acyl taurate surfactant mixtures | |
US20230332072A1 (en) | Naturally derived surfactant system and composition comprising the same | |
US11382847B2 (en) | High polyol wash composition | |
JP5495709B2 (ja) | 皮膚洗浄剤組成物 | |
CN114980978A (zh) | 可水合的浓缩表面活性剂组合物 | |
RU2812260C2 (ru) | Ламеллярные жидкие очищающие средства, содержащие смеси поверхностно-активных веществ ацилизетионата и метилацилтаурата | |
US20230398050A1 (en) | Stable wash composition | |
WO2024002892A1 (en) | Anti-acne composition | |
US20240189202A1 (en) | Hydratable concentrated surfactant composition substantially free of isethionates | |
CN117580561A (zh) | 含酯的可水合浓缩表面活性剂组合物 | |
JP2024523935A (ja) | エステルを含む水和可能な濃縮界面活性剤組成物 | |
CN117597100A (zh) | 包含具有限定重量百分比的氧的化合物的可水合浓缩表面活性剂组合物 | |
US20240216232A1 (en) | Compositions having low sulfate containing surfactants | |
WO2024002645A1 (en) | Reduced palm kernel reliant wash composition | |
US20230263717A1 (en) | Naturally derived surfactant system with polyglycerol esters and compositions comprising the same | |
JP2024525217A (ja) | 規定の重量パーセントの酸素を有する化合物を含む水和性濃縮界面活性剤組成物 | |
WO2024002646A1 (en) | Stable wash composition with biodegradable thickener | |
CN115884750A (zh) | 防腐剂体系和包含其的组合物 | |
US20210299013A1 (en) | Compositions Comprising Naturally Derived Preservatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |