CN115160295A - 作为激酶抑制剂的酰胺化合物 - Google Patents

作为激酶抑制剂的酰胺化合物 Download PDF

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Publication number
CN115160295A
CN115160295A CN202210797866.4A CN202210797866A CN115160295A CN 115160295 A CN115160295 A CN 115160295A CN 202210797866 A CN202210797866 A CN 202210797866A CN 115160295 A CN115160295 A CN 115160295A
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alkyl
nhc
cycloalkyl
compound
aryl
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Chinese (zh)
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T·王
S·盖特利
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Translational Drug Development LLC
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Translational Drug Development LLC
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Publication of CN115160295A publication Critical patent/CN115160295A/zh
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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CN202210797866.4A 2016-10-24 2017-10-24 作为激酶抑制剂的酰胺化合物 Pending CN115160295A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662411908P 2016-10-24 2016-10-24
US62/411,908 2016-10-24
PCT/US2017/058071 WO2018081108A1 (en) 2016-10-24 2017-10-24 Amide compounds as kinase inhibitors
CN201780079730.7A CN110099906B (zh) 2016-10-24 2017-10-24 作为激酶抑制剂的酰胺化合物

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CN201780079730.7A Expired - Fee Related CN110099906B (zh) 2016-10-24 2017-10-24 作为激酶抑制剂的酰胺化合物

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EP (1) EP3532479B1 (https=)
JP (1) JP6948398B2 (https=)
CN (2) CN115160295A (https=)
AU (1) AU2017351216C1 (https=)
CA (1) CA3078347A1 (https=)
IL (2) IL266150B2 (https=)
WO (1) WO2018081108A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112367982A (zh) * 2018-04-24 2021-02-12 转化药物开发有限责任公司 作为激酶抑制剂的酰胺化合物、组合物和治疗方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019201297A1 (zh) * 2018-04-18 2019-10-24 南京明德新药研发有限公司 作为rho激酶抑制剂的苯并吡唑类化合物
WO2019201296A1 (zh) * 2018-04-18 2019-10-24 南京明德新药研发有限公司 作为rho激酶抑制剂的吡唑类化合物
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