CN115154500A - Traditional Chinese medicine composition capable of improving blood flow and resisting anoxia and preparation method - Google Patents
Traditional Chinese medicine composition capable of improving blood flow and resisting anoxia and preparation method Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention relates to the technical field of traditional Chinese medicine compositions, and discloses an anoxia-resistant traditional Chinese medicine composition capable of improving blood flow and a preparation method thereof, wherein the anoxia-resistant traditional Chinese medicine composition comprises 15-30 parts of salvia miltiorrhiza extract, 20-35 parts of astragalus extract, 10-20 parts of pseudo-ginseng extract and 35-55 parts of corn dextrin, and comprises the following steps: s1, ultrasonically extracting a salvia miltiorrhiza medicinal material from coarse salvia miltiorrhiza powder by using low-concentration ethanol, pulverizing the salvia miltiorrhiza medicinal material into powder, and freeze-drying the powder into dark brown powder by using a freeze-drying technology; s2, pulverizing the pseudo-ginseng and the astragalus into powder, and carrying out ultrasonic heating extraction for 1-2 times by taking hot water as a solvent; adding aqueous ethanol into the residue, and ultrasonic extracting for 1-2 times; s3, mixing the red sage root freeze-dried powder obtained in the first step with the extract obtained in the second step, stirring and mixing uniformly, placing the mixture in a vacuum freeze-drying box (the vacuum degree is-0.06 MPa to-0.08 MPa) at-60 to-10 ℃ (preferably-30 to-40 ℃) to dry into a dry extract, and crushing the dry extract; s4, adding auxiliary materials and different preparations, adding corn dextrin, sodium carboxymethylcellulose and the like, and preparing into granules, tablets, pills, capsules and the like.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition capable of improving blood flow and resisting anoxia and a preparation method thereof.
Background
Blood circulation, the basic structural and functional unit in the circulatory system, includes the circulation of body fluids within arteries, arterioles, veins, venules, lymphatic capillaries, and tissue tracts. Circulatory disorders often occur in pathological conditions such as inflammatory reactions, metabolic disorders, cardiac hypoxia and the like, and are clinically manifested by reduced blood flow of blood vessels, endothelial cell damage, increased vascular permeability, reduced vascular reactivity, leukocyte adhesion and migration due to the change of physical and chemical properties of blood. The circulatory disturbance almost has close relationship with all system diseases, and is better to be caused by diseases such as cerebral apoplexy, coronary heart disease, diabetes, hypertension, acute pancreatitis, sudden deafness and the like, clinically, corresponding treatment methods are selected according to different diseases, so as to achieve the purposes of expanding blood vessels in an ischemic area and the surrounding blood vessels, improving various indexes of hemorheology, reducing endothelial injury and the like.
At present, different treatment methods are adopted for different diseases when blood vessels in and around an ischemic area and blood rheology are improved, so that the treatment difficulty is high, the treatment process is complex, and particularly, the traditional Chinese medicinal materials are generally adopted for decocting auxiliary medicaments in the traditional Chinese medicine treatment process, so that the preparation process is time-consuming, the storage time is short, and meanwhile, effective components among the medicinal materials cannot be well extracted and act together.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides the traditional Chinese medicine composition capable of improving blood flow and resisting anoxia and the preparation method thereof, and the traditional Chinese medicine composition has the advantages of fully utilizing the internal active ingredients of the traditional Chinese medicines to ensure that the preservation effect of the finished product is better and the like, and solves the technical problems.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: a traditional Chinese medicine composition capable of improving blood flow and resisting anoxia comprises the following components in parts by weight: 15-30 parts of salvia miltiorrhiza extract, 20-35 parts of astragalus extract, 10-20 parts of pseudo-ginseng extract and 35-55 parts of corn dextrin.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 15 parts of salvia miltiorrhiza extract, 20 parts of astragalus extract, 10 parts of pseudo-ginseng extract and 55 parts of corn dextrin.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 20 parts of salvia miltiorrhiza extract, 30 parts of astragalus extract, 15 parts of pseudo-ginseng extract and 35 parts of corn dextrin.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 25 parts of salvia miltiorrhiza extract, 25 parts of astragalus extract, 10 parts of pseudo-ginseng extract and 40 parts of corn dextrin.
Preferably, the preparation method of the traditional Chinese medicine composition capable of improving blood flow and resisting anoxia comprises the following steps:
s1, ultrasonically extracting a salvia miltiorrhiza medicinal material from coarse powder of the salvia miltiorrhiza by using low-concentration ethanol, pulverizing the powder, ultrasonically extracting the powder for 2-3 times by using aqueous ethanol (20 to 80%) as a solvent at low temperature, concentrating the obtained extract by using a membrane concentration technology, and freeze-drying the concentrate into dark brown powder by using a freeze-drying technology;
s2, pulverizing the pseudo-ginseng and the astragalus into powder, and carrying out ultrasonic heating extraction for 1-2 times by taking hot water as a solvent; adding aqueous ethanol into the residue, and ultrasonic extracting for 1-2 times;
s3, mixing the freeze-dried powder of the salvia miltiorrhiza extracted in the first step into the extract obtained in the second step, stirring and mixing uniformly, placing the mixture into a vacuum freeze-drying box (the vacuum degree is-0.06 MPa to-0.08 MPa) at-60 ℃ to-10 ℃ (preferably-30 ℃ to-40 ℃), drying the mixture to prepare dry extract, and crushing the dry extract;
s4, adding auxiliary materials and different preparations, adding corn dextrin, sodium carboxymethyl cellulose and the like, and preparing granules, tablets, pills, capsules and the like.
In the ultrasonic extraction process, the power is preferably 20 to 40 KHz (kilohertz), and the power is further preferably 30KHz; the temperature is preferably 20 to 27 ℃, and more preferably 25 ℃; the extraction time is preferably 24 to 40, and more preferably 30min; the mass-volume ratio of the medicinal materials to the hydrous ethanol is preferably 5g:200 mL-10 g:500mL, more preferably 5g:200mL. The particle size of the mixture fine powder is preferably 20-200 meshes, and more preferably 40 meshes.
Further mixing the obtained extractive solutions, and concentrating by membrane concentration technology to obtain brown extract (1.32-1.38 (60 deg.C)); the concentration of the ethanol in the extraction process is preferably 50-80%, and further preferably 70%; the mass ratio of the traditional Chinese medicine to the water is preferably 13 to 6, and more preferably 15; the mass ratio of the traditional Chinese medicine to the hydrous ethanol is preferably 13 to 5, and more preferably 14; the extraction temperature is preferably 50 to 90 ℃ when the aqueous ethanol is extracted, and more preferably 80 ℃; the ethanol extraction time is preferably 2 to 3h, and more preferably 2h.
Further screening salvianolic acid and tanshinone components in the salvia miltiorrhiza technical extract as main major components of the salvia miltiorrhiza QMARKER; the main process is alcohol extraction.
Further extracting radix astragali by combining alcohol extraction and water extraction.
Further extracting Notoginseng radix by combining ethanol extraction and water extraction.
Compared with the prior art, the invention provides the traditional Chinese medicine composition capable of improving blood flow and resisting anoxia and the preparation method thereof, and the traditional Chinese medicine composition has the following beneficial effects:
1. the traditional Chinese medicine composition capable of improving blood flow and resisting anoxia ensures the yield of tanshinone and salvianolic acid which are active ingredients of the salvia miltiorrhiza by utilizing an aqueous ethanol and ultrasonic extraction scheme, and ensures that the active ingredients of the salvia miltiorrhiza are not denatured by controlling the extraction temperature and freeze drying; ultrasonically extracting with water and aqueous ethanol to obtain large amount of polysaccharides from Notoginseng radix and radix astragali, fully extracting saponins active components from the two medicinal materials, and freeze drying to prevent active components from denaturation; the radix notoginseng and astragalus polysaccharide are used as concentrated extracts mainly composed, the radix salviae miltiorrhizae extract is fully dissolved and dispersed, and the dried radix notoginseng and astragalus polysaccharide protect easily-oxidized substances such as tanshinone, salvianolic acid and the like, so that the content and synergistic effect of the effective components of the compound are effectively ensured, and the beneficial effects that the effective components in the traditional Chinese medicinal materials are utilized to ensure that the finished product has better preservation effect are achieved.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
A traditional Chinese medicine composition capable of improving blood flow and resisting anoxia comprises the following steps:
s1, mixing the mixture 1
10 parts of red sage root coarse powder, namely ultrasonically extracting a red sage root medicinal material by using low-concentration ethanol, pulverizing the red sage root medicinal material, ultrasonically extracting for 2-3 times at low temperature by using aqueous ethanol (20-80%) as a solvent, concentrating the obtained extract by using a membrane concentration technology, and freeze-drying the concentrate by using a freeze-drying technology to obtain dark brown powder;
s2, pulverizing 10 parts of pseudo-ginseng and 20 parts of astragalus into powder, and carrying out ultrasonic heating extraction for 1-2 times by taking hot water as a solvent; adding aqueous ethanol into the residue, and ultrasonic extracting for 1-2 times;
s3, mixing the freeze-dried powder of the salvia miltiorrhiza extracted in the first step into the extract obtained in the second step, stirring and mixing uniformly, placing the mixture into a vacuum freeze-drying box (the vacuum degree is-0.06 MPa to-0.08 MPa) at-60 ℃ to-10 ℃ (preferably-30 ℃ to-40 ℃), drying the mixture to prepare dry extract, and crushing the dry extract;
s4, adding auxiliary materials and different preparations, adding 55 parts of corn dextrin, sodium carboxymethylcellulose and the like, and preparing into granules, tablets, pills, capsules and the like.
The red sage root has the functions of promoting blood circulation to disperse blood clots, dredging meridian, relieving pain, clearing away heart fire, relieving restlessness, cooling blood and eliminating carbuncle. The traditional Chinese medicine composition has the effects of treating chest stuffiness and pains, abdominal and hypochondriac pains, abdominal mass accumulation and heat arthralgia pains, is matched with pseudo-ginseng with the effects of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain, utilizes the blood circulation of the pseudo-ginseng to drive blood flow, further utilizes the effects of tonifying qi and consolidating exterior, expelling toxin and pus, promoting urination and promoting tissue regeneration of astragalus to improve blood flow.
Example two
A traditional Chinese medicine composition capable of improving blood flow and resisting anoxia comprises the following steps:
s1, performing ultrasonic extraction on 20 parts of salvia miltiorrhiza coarse powder by using low-concentration ethanol, pulverizing the salvia miltiorrhiza medicinal material, performing ultrasonic low-temperature extraction for 2-3 times by using aqueous ethanol (20 to 80%) as a solvent, concentrating the obtained extract by using a membrane concentration technology, and freeze-drying the concentrate by using a freeze-drying technology to obtain dark brown powder;
s2, grinding 15 parts of pseudo-ginseng and 30 parts of astragalus into powder, and carrying out ultrasonic heating extraction for 1-2 times by taking hot water as a solvent; adding aqueous ethanol into the residue, and ultrasonic extracting for 1-2 times;
s3, mixing the red sage root freeze-dried powder obtained in the first step with the extract obtained in the second step, stirring and mixing uniformly, placing the mixture in a vacuum freeze-drying box (the vacuum degree is-0.06 MPa to-0.08 MPa) at-60 to-10 ℃ (preferably-30 to-40 ℃) to dry into a dry extract, and crushing the dry extract;
s4, adding auxiliary materials and different preparations, adding 35 parts of corn dextrin, sodium carboxymethylcellulose and the like, and preparing into granules, tablets, pills, capsules and the like.
The red sage root has the functions of promoting blood circulation to disperse blood clots, dredging meridian, relieving pain, clearing away heart fire, relieving restlessness, cooling blood and eliminating carbuncle. The traditional Chinese medicine composition has the effects of treating chest stuffiness and pains, abdominal and hypochondriac pains, abdominal mass accumulation and heat arthralgia pains, is matched with pseudo-ginseng with the effects of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain, utilizes the blood circulation of the pseudo-ginseng to drive blood flow, further utilizes the effects of tonifying qi and consolidating exterior, expelling toxin and pus, promoting urination and promoting tissue regeneration of astragalus to improve blood flow.
EXAMPLE III
A traditional Chinese medicine composition capable of improving blood flow and resisting anoxia comprises the following steps:
s1, performing ultrasonic extraction on 20 parts of salvia miltiorrhiza coarse powder by using low-concentration ethanol, pulverizing the salvia miltiorrhiza medicinal material, performing ultrasonic low-temperature extraction for 2-3 times by using aqueous ethanol (20 to 80%) as a solvent, concentrating the obtained extract by using a membrane concentration technology, and freeze-drying the concentrate by using a freeze-drying technology to obtain dark brown powder;
s2, pulverizing 10 parts of pseudo-ginseng and 25 parts of astragalus into powder, and carrying out ultrasonic heating extraction for 1-2 times by taking hot water as a solvent; adding aqueous ethanol into the residue, and ultrasonic extracting for 1-2 times;
s3, mixing the red sage root freeze-dried powder obtained in the first step with the extract obtained in the second step, stirring and mixing uniformly, placing the mixture in a vacuum freeze-drying box (the vacuum degree is-0.06 MPa to-0.08 MPa) at-60 to-10 ℃ (preferably-30 to-40 ℃) to dry into a dry extract, and crushing the dry extract;
s4, adding auxiliary materials and different preparations, adding 40 parts of corn dextrin, sodium carboxymethylcellulose and the like, and preparing into granules, tablets, pills, capsules and the like.
The red sage root has the functions of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart fire and relieving restlessness, cooling blood and eliminating carbuncle. The traditional Chinese medicine composition has the effects of treating chest stuffiness and pains, abdominal and hypochondriac pain, abdominal mass and heat stuffiness and pains, is matched with pseudo-ginseng for removing blood stasis and stopping bleeding, activating blood and relieving pain, utilizes the pseudo-ginseng for activating blood to drive blood to flow, further utilizes astragalus root for tonifying qi and consolidating exterior, expelling toxin and pus, inducing diuresis, promoting tissue regeneration and improving blood flow.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. A traditional Chinese medicine composition capable of improving blood flow and resisting anoxia is characterized in that: the traditional Chinese medicine composition comprises the following components in parts by weight: 15-30 parts of salvia miltiorrhiza extract, 20-35 parts of astragalus extract, 10-20 parts of pseudo-ginseng extract and 35-55 parts of corn dextrin.
2. The hypoxia-resistant traditional Chinese medicine composition capable of improving blood flow according to claim 1, wherein the composition comprises: the traditional Chinese medicine composition comprises the following components in parts by weight: 15 parts of salvia miltiorrhiza extract, 20 parts of astragalus extract, 10 parts of pseudo-ginseng extract and 55 parts of corn dextrin.
3. The hypoxia-resistant traditional Chinese medicine composition capable of improving blood flow according to claim 1, wherein the composition comprises: the traditional Chinese medicine composition comprises the following components in parts by weight: 20 parts of salvia miltiorrhiza extract, 30 parts of astragalus extract, 15 parts of pseudo-ginseng extract and 35 parts of corn dextrin.
4. The hypoxia-resistant traditional Chinese medicine composition capable of improving blood flow according to claim 1, wherein the composition comprises: the traditional Chinese medicine composition comprises the following components in parts by weight: 25 parts of salvia miltiorrhiza extract, 25 parts of astragalus extract, 10 parts of pseudo-ginseng extract and 40 parts of corn dextrin.
5. The preparation method of the hypoxia tolerance traditional Chinese medicine composition for improving blood flow according to claim 1, is characterized by comprising the following steps:
s1, ultrasonically extracting a salvia miltiorrhiza medicinal material from coarse salvia miltiorrhiza powder by using low-concentration ethanol, pulverizing the salvia miltiorrhiza medicinal material into powder, ultrasonically extracting the powder for 2-3 times at low temperature by using aqueous ethanol (20-80%) as a solvent, concentrating the obtained extract by using a membrane concentration technology, and freeze-drying the concentrate into dark brown powder by using a freeze-drying technology;
s2, pulverizing the pseudo-ginseng and the astragalus into powder, and carrying out ultrasonic heating extraction for 1-2 times by taking hot water as a solvent; adding aqueous ethanol into the residue, and ultrasonic extracting for 1-2 times;
s3, mixing the red sage root freeze-dried powder obtained in the first step with the extract obtained in the second step, stirring and mixing uniformly, placing the mixture in a vacuum freeze-drying box (the vacuum degree is-0.06 MPa to-0.08 MPa) at-60 to-10 ℃ (preferably-30 to-40 ℃) to dry into a dry extract, and crushing the dry extract;
s4, adding auxiliary materials and different preparations, adding corn dextrin, sodium carboxymethylcellulose and the like, and preparing into granules, tablets, pills, capsules and the like.
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| CN1778340A (en) * | 2004-11-26 | 2006-05-31 | 天津天士力制药股份有限公司 | Chinese medicine composition for treating coronary heart disease and angina cordis |
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| CN1778340A (en) * | 2004-11-26 | 2006-05-31 | 天津天士力制药股份有限公司 | Chinese medicine composition for treating coronary heart disease and angina cordis |
| CN1857394A (en) * | 2006-03-22 | 2006-11-08 | 广州中医药大学第二临床医学院 | Medicine composition of effective parts for compound Tongmai Chinese medicine oral liquid and its preparing method |
| CN101433584A (en) * | 2008-12-12 | 2009-05-20 | 上海禾丰制药有限公司 | Pharmaceutical composition for treating qi deficiency and blood stasis type coronary heart disease and preparation method thereof |
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