CN115154497A - Composition for enhancing immunity and preparation method thereof - Google Patents
Composition for enhancing immunity and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a composition for enhancing immunity and a preparation method thereof, wherein the extract takes maca and ginseng as raw materials, distilled water as a solvent, and the ratio of materials to liquid is 1: 8. The preparation method comprises the following steps: pulverizing Lepidium Meyenii Walp and Ginseng radix into coarse powder, decocting in water for 1 hr, and filtering to obtain 1 extractive solution; decocting with water for 1 hr, and filtering to obtain 2 times extractive solution; mixing the two extractive solutions, and concentrating to obtain the composition with immunity enhancing effect. The composition can improve mouse carbon clearance, phagocytosis rate and phagocytosis index of chicken erythrocyte phagocytosis, and swelling degree of foot sole of mouse.
Description
Technical Field
The invention relates to the field of health-care food and medicines, in particular to a composition for enhancing immunity and a preparation method thereof.
Background
The immunity is a physiological function of the human body, and the immune system consists of immune organs, immune cells and immune active substances. The human immune system exerts immune surveillance, defense and self-stabilization through specific immunity and non-specific immunity to destroy and reject antigen substances (such as germs, etc.) entering the human body, or damaged cells and tumor cells, etc. generated by the human body itself, to maintain the health of the human body. If the immunity of the human body is reduced or abnormal, various diseases are easily caused.
The regulation function of qi, blood, yin and yang in the theory of traditional Chinese medicine is similar to the function of immune system, for example, the theory of ' Wei Wen & Bi Lun ' describes that the Han Qi of water valley is also smooth and unsmooth, and can not enter the pulse, so that the Han Qi circulates in the skin, is divided into flesh, fumigated in the blind membrane and scattered in the chest and abdomen ', and the Wei Qi has the meaning of defending and defending, and can resist exogenous pathogens. In Ling Shu & Ben zang, defensive qi can warm the flesh, fill the skin, fatten the striae and open and shut the body, and yang qi can regulate the defense of skin and skin surface and the body temperature. Pharmacological research also finds that the traditional Chinese medicine has dual functions of regulating the immune function, namely immune activation and immune suppression. It is reported that Chinese herbs have an influence on immune cells and immune factors related to immune response, and regulate nonspecific immune system activity and adaptive immune cell subpopulation.
With the deepening of understanding of diseases, immunomodulators and health foods are gradually favored by people. The application provides a traditional Chinese medicine composition with immunity enhancement function and a preparation method thereof through research, and the traditional Chinese medicine composition has good synergistic effect.
Disclosure of Invention
The invention aims to provide a novel composition with the function of enhancing immunity, which has obvious compatibility advantage and obvious synergistic effect for enhancing the activity of the immunity of organisms.
In order to achieve the above purpose of the present invention, the following technical solutions are adopted:
the traditional Chinese medicine composition for enhancing immunity is characterized in that the raw material medicines of the traditional Chinese medicine composition mainly comprise maca and ginseng in a weight ratio of: maca to ginseng = 1-6: 1, or maca to ginseng = 2-5: 1, or maca to ginseng = 2-4: 1, or maca to ginseng = 3-6: 1.
The traditional Chinese medicine composition for enhancing immunity is characterized in that raw material medicines of the traditional Chinese medicine composition mainly comprise maca and ginseng in a weight ratio of: the ratio of maca to ginseng is = 2: 1, or the ratio of maca to ginseng is = 3: 1, or the ratio of maca to ginseng is = 4: 1, or the ratio of maca to ginseng is = 5: 1, and the ratio of maca to ginseng is = 6: 1.
The traditional Chinese medicine composition for enhancing immunity is characterized in that raw material medicines of the traditional Chinese medicine composition are maca and ginseng, and the weight ratio of the maca to the ginseng is as follows: maca to ginseng = 1-6: 1, or maca to ginseng = 2-5: 1, or maca to ginseng = 2-4: 1, or maca to ginseng = 3-6: 1.
The traditional Chinese medicine composition for enhancing immunity is characterized in that raw material medicines of the traditional Chinese medicine composition are maca and ginseng, and the weight ratio of the maca to the ginseng is as follows: maca to ginseng = 2: 1, or maca to ginseng = 3: 1, or maca to ginseng = 4: 1, or maca to ginseng = 5: 1, or maca to ginseng = 6: 1.
The preparation method of the composition for enhancing immunity as claimed in the present application comprises the following steps:
1) Crushing dried maca and ginseng to obtain coarse maca and ginseng powder;
2) Weighing the maca and the ginseng coarse powder according to the weight ratio of the raw materials, adding purified water, decocting for 1-3 hours, and filtering to obtain filtrate, wherein the weight ratio of water to the coarse powder is = 8-12: 1;
3) Adding purified water into the filter residue obtained in the step 2 according to the proportion in the step 2, and continuously decocting for 1-2 hours to obtain filtrate;
4) And (4) combining the filtrates obtained in the step (2) and the step (3), and concentrating to obtain a concentrated solution of the composition for enhancing the immunity.
Wherein, the weight ratio of water to the coarse powder in the step 2) is = 8-10: 1, or the weight ratio of water to the coarse powder is = 8: 1; decocting for 2-3 hours or decocting for 2 hours; in the step 3), decocting is continued for 1 hour and filtering is carried out.
The preparation method of the traditional Chinese medicine composition for enhancing immunity is characterized in that the concentrated solution is further purified. The purification treatment comprises diluting the concentrated solution, loading on column, eluting, and separating to obtain purified product.
The application provides an application of the traditional Chinese medicine composition for enhancing immunity in preparation of health-care food, food and medicines for enhancing immunity.
The invention aims to provide application of the traditional Chinese medicine composition for enhancing immunity in medicines or health-care products with the function of enhancing immunity, and preferably application in preparation of medicines or health-care products for enhancing immunity.
Detailed description of the preferred embodiments
Embodiments of the present invention will now be described in detail with reference to the following examples, which are intended to be illustrative of the present invention and should not be construed as limiting the scope of the invention.
Example 1
The traditional Chinese medicine composition for enhancing immunity is characterized in that raw material medicines of the traditional Chinese medicine composition are maca and ginseng, and the weight ratio of the maca to the ginseng is as follows: maca and ginseng = 2: 1,
the preparation method of the traditional Chinese medicine composition for enhancing immunity comprises the following steps:
1. the content ratio of the maca to the ginseng is as follows: maca and ginseng are = 2: 1, and dry maca and ginseng medicinal materials are crushed to obtain coarse maca and ginseng powder;
2. weighing the maca and the ginseng coarse powder according to the ratio of 2: 1, adding purified water, wherein the ratio of water to coarse powder is = 8: 1, decocting for 2 hours, and filtering to obtain filtrate;
3. adding purified water into the filter residue obtained in the step 2 according to the proportion in the step 2, continuously decocting for 1 hour, and filtering to obtain a filtrate;
4. and (3) combining the filtrates obtained in the step (2) and the step (3), and concentrating to obtain the concentrated solution of the composition for enhancing the immunity.
5. The concentrated solution can be prepared into oral preparations such as tablets, granules, pills, oral liquid and the like according to the conventional method of traditional Chinese medicine pharmacy.
Example 2
The traditional Chinese medicine composition for enhancing immunity is characterized in that raw materials of the traditional Chinese medicine composition comprise maca and ginseng in a weight ratio of: or maca and ginseng = 3: 1
The preparation method of the traditional Chinese medicine composition for enhancing immunity comprises the following steps:
1. the content ratio of the maca to the ginseng is as follows: maca and ginseng = 3: 1, and dry maca and ginseng medicinal materials are crushed to obtain coarse maca and ginseng powder;
2. weighing the maca and the ginseng coarse powder according to the ratio of 3: 1, adding purified water, wherein the ratio of water to coarse powder is = 8: 1, decocting for 2 hours, and filtering to obtain filtrate;
3. adding purified water into the filter residue obtained in the step 2 according to the proportion in the step 2, continuously decocting for 1 hour, and filtering to obtain a filtrate;
4. and (3) combining the filtrates obtained in the step (2) and the step (3), and concentrating to obtain the concentrated solution of the composition for enhancing the immunity.
Example 3
The traditional Chinese medicine composition for enhancing immunity is characterized in that raw materials of the traditional Chinese medicine composition comprise maca and ginseng in a weight ratio of: maca and ginseng = 4: 1,
the preparation method of the traditional Chinese medicine composition for enhancing immunity comprises the following steps:
1. the content ratio of the maca to the ginseng is as follows: maca and ginseng are in a ratio of = 4: 1, and dry maca and ginseng medicinal materials are crushed to obtain coarse maca and ginseng powder;
2. weighing the maca and the ginseng coarse powder according to the ratio of 4: 1, adding purified water, wherein the ratio of water to coarse powder is = 8: 1, decocting for 2 hours, and filtering to obtain filtrate;
3. adding purified water into the filter residue obtained in the step 2 according to the proportion in the step 2, continuously decocting for 1 hour, and filtering to obtain a filtrate;
4. and (3) combining the filtrates obtained in the step (2) and the step (3), and concentrating to obtain the concentrated solution of the composition for enhancing the immunity.
Example 4
The traditional Chinese medicine composition for enhancing immunity is characterized in that raw material medicines of the traditional Chinese medicine composition are maca and ginseng, and the weight ratio of the maca to the ginseng is as follows: maca and ginseng = 5: 1,
the preparation method of the traditional Chinese medicine composition for enhancing immunity comprises the following steps:
1. the content ratio of the maca to the ginseng is as follows: maca and ginseng are in a ratio of 5: 1, and dry maca and ginseng medicinal materials are crushed to obtain coarse maca and ginseng powder;
2. weighing the maca and the ginseng coarse powder according to the ratio of 5: 1, adding purified water, wherein the ratio of water to coarse powder is = 8: 1, decocting for 2 hours, and filtering to obtain filtrate;
3. adding purified water into the filter residue obtained in the step 2 according to the proportion in the step 2, continuously decocting for 1 hour, and filtering to obtain a filtrate;
4. and (4) combining the filtrates obtained in the step (2) and the step (3), and concentrating to obtain a concentrated solution of the composition for enhancing the immunity.
Example 5
The traditional Chinese medicine composition for enhancing immunity is characterized in that raw material medicines of the traditional Chinese medicine composition are maca and ginseng, and the weight ratio of the maca to the ginseng is as follows: maca to ginseng = 6: 1.
The preparation method of the traditional Chinese medicine composition for enhancing immunity comprises the following steps:
1. the content ratio of the maca to the ginseng is as follows: maca and ginseng are in a ratio of 6: 1, and dry maca and ginseng medicinal materials are crushed to obtain coarse maca and ginseng powder;
2. weighing the maca and the ginseng coarse powder according to the ratio of 6: 1, adding purified water, wherein the ratio of water to coarse powder is = 8: 1, decocting for 2 hours, and filtering to obtain filtrate;
3. adding purified water into the filter residue obtained in the step 2 according to the proportion in the step 2, continuously decocting for 1 hour, and filtering to obtain a filtrate;
4. and (3) combining the filtrates obtained in the step (2) and the step (3), and concentrating to obtain the concentrated solution of the composition for enhancing the immunity.
Effect test:
in order to determine the compatibility proportion of the maca ginseng, a result test study is carried out.
Effect test 1 delayed type allergy (DTH) test
After adaptive feeding observation for 3d of SPF-grade KM mice, the mice are randomly divided into 4 groups, namely a control group, a low-dose group, a medium-dose group and a high-dose group of tested objects, wherein each group contains 12 tested objects, the tested objects are orally taken once a day, and the mice are continuously gazed for 42d.
Animals: KM mice, SPF level, female, body constitution 16 g-20 g, provided by Beijing Huafukang biotech GmbH, animal license number SYXK (Kyoto) 2017-0038, are raised in a barrier environment.
Preparation of the medicament: 12g of maca and 3g of ginseng, crushing the medicinal materials into coarse powder, adding 8 times of water, decocting for 2 times, 1 hour each time, filtering, combining filtrates, concentrating to obtain brown liquid, and refrigerating for storage.
Administration: mice were dosed with 1.25, 2.50, 7.50g/kgBW, at low, medium, and high doses.
The experimental method comprises the following steps: 48 KM female mice are selected and randomly divided into blank control groups and 12 groups with high, medium and low dosages of maca-ginseng water decoction according to the body mass. Each test group is given a corresponding dose of maca-ginseng water decoction, and a blank control group is given equal volume of distilled water (10 mL/kg) for intragastric administration 1 time a day for 42 consecutive days.
Index detection: sheep blood was taken, washed 3 times with physiological saline, and mice were intraperitoneally injected with 0.2mL of 2% SRBC suspension, and the thickness of the plantar portion of the left hind paw of the mice was measured 4d after sensitization. 20 μ L of 20% SRBC suspension was injected subcutaneously at the site of measurement, and the thickness of the left hind foot plantar region of the mice was measured 24h after injection. The two measurements are all at the same position, and the average value is taken after three measurements. The degree of delayed-type allergy was expressed as the difference in thickness of the plantar aspect of the foot before and after the challenge.
TABLE 1 Effect of different doses of test substances on delayed hypersensitivity
* : compared with the 0mL/kgBW group, the composition has significant difference
As can be seen from Table 1, the mice given different doses of the test substance 42d orally showed significant differences between the 1.8mL/kgBW group and the 5.4mL/kgBW group 1, as compared to the 0mL/kgBW group.
Effect test 2 measurement of the number of antibody-producing cells
Grouping and administration were performed in the same manner as in test 1. Index detection: collecting sanguis Caprae Seu Ovis, washing with physiological saline for 3 times, and injecting 0.2mL2% SRBC suspension into abdominal cavity of mouse. Mice immunized with SRBC for 5 days were sacrificed, and spleen was taken and ground to prepare a cell suspension. After centrifugation, the cells were washed 2 times with Hank's solution, respectively, and suspended in 8.0mL of Hank's solution. After the agarose had dissolved, it was mixed with an equal amount of doubled Hank's solution, dispensed in small tubes, 0.5mL per tube, and 50. Mu.L of 10-percent SRBC suspension and 8. Mu.L of spleen cell suspension were added to the tube, mixed rapidly, poured onto a slide with a thin agarose layer, after the agar had solidified, incubated in a CO2 incubator for 1h, added to the groove of the slide holder complement diluted 8 times with SA buffer, incubated for 1.5h, and then the number of hemolytic plaques was counted. The number of antibody-producing cells was expressed as the number of plaques/whole spleen cells.
TABLE 2 Effect of different doses of test substance on the number of antibody-producing cells
* : compared with the 0mL/kgBW group, the composition has significant difference
As shown in Table 2, after the mice are orally administered with different doses of the test substance 42d, the number of hemolytic plaques of the mice in the 5.4mL/kgBW group is increased compared with that in the 0mL/kgBW group, and the difference is significant.
Effect test 3 mouse carbon clearance test
Selecting 48 KM female mice, and randomly dividing into blank control groups and high, medium and low dose groups of maca-ginseng water decoction according to the body mass, wherein each group comprises 12 mice. Each test group is given a corresponding dose of maca-ginseng water decoction, and a blank control group is given equal volume of distilled water (10 mL/kg) for intragastric administration 1 time a day for 42 consecutive days. Index detection: diluted India ink (0.05 mL/10 gBW) was injected intravenously from the mouse tail according to body mass. After filling with ink 220 μ L of blood was collected from the mouse inner canthus venous plexus, and the blood was 2.0mL 0.1% 2 CO 3 In solution. Measuring optical density value (OD) with UV2600 UV spectrophotometer at 600nm wavelength, 0.1% of Na 2 CO 3 The solution served as a blank. Mice were sacrificed and livers and spleens were weighed. Phagocytosis index (a) was calculated according to the formula and represents the ability of mouse to clear carbon. OD in the formula 1 、OD 2 The optical density value, t, of blood obtained by blood sampling at 2min and 10min respectively 1 、t 2 The blood sampling time after the injection of India ink is shown.
k＝(lgOD 1 -lgOD 2 )/(t 2 -t 1 )
a = body weight ÷ (liver weight + spleen weight) × k 1/3
TABLE 3 Effect of administering different doses of test substance on carbon clearance Capacity
* : compared with the 0mL/kgBW group, the composition has significant difference
As can be seen from table 3, after the mice were orally administered with different doses of the test substance 42d, the phagocytic index of the mice in each dose group was improved, and there was a significant difference compared with the 0mL/kgBW group.
Effect test 4 mouse abdominal macrophage phagocytosis of chicken erythrocytes test
Grouping and administration were performed in the same manner as in test 1. Index detection: after injecting 20% chicken red blood cell suspension into abdominal cavity 1mL for 30min, the mouse is killed, and then injected with 2mL physiological saline into abdominal cavity, and kneaded on the abdomen 20 times. 1mL of mouse peritoneal macrophage wash solution was dropped on 2 slides, and incubated at 37 ℃ for 30min. Rinsing with physiological saline, air drying, fixing with 1: 1 acetone methanol solution, staining with Giemsa-phosphate buffer, rinsing with distilled water, and air drying. Counting under oil lens condition, counting 100 macrophages per tablet, and calculating phagocytosis rate and phagocytosis index according to the following formulaThe obtained phagocytosis percentage is subjected to data conversion according to the following formula,
p represents the percent phagocytosis expressed in decimal numbers.
Percent (%) phagocytosis = number of macrophages engulfing chicken red blood cells/number of macrophages counted × 100%
Phagocytosis index = total number of chicken erythrocytes phagocytosed/number of macrophages counted
TABLE 4 Effect of different doses of test Agents on the phagocytosis rate of chicken erythrocytes by macrophages
* : compared with the 0mL/kgBW group, the composition has significant difference
As shown in Table 4, after the test substance was orally administered to the mice at different doses for 42d, the rate of phagocytosis of chicken erythrocytes by macrophages in mice in each dose group was increased, compared with the 0mL/kgBW group, and the rate was significantly different.
TABLE 5 Effect of administration of varying doses of test Agents on the phagocytic index of chicken erythrocytes by macrophages
As shown in Table 5, after the test substance was orally administered to the mice at different doses for 42d, the phagocytic index of the macrophages phagocytosed chicken erythrocytes in the mice in each dose group was increased, and the two doses were significantly different from each other compared with the 0mL/kgBW group.
After the maca-ginseng water decoction is orally administered to the mice for 42 days, compared with a blank control group, the maca-ginseng water decoction can obviously improve the carbon clearance capacity (P is less than 0.05 or P is less than 0.01) of the mice at low, medium and high doses, and can obviously improve the phagocytosis rate and the phagocytosis index (P is less than 0.05 or P is less than 0.01) of chicken erythrocytes phagocytized by macrophages of the mice at low, medium and high doses; the swelling degree of the foot of a mouse can be obviously improved by the maca-ginseng decoction liquid with middle and high dose (P is less than 0.05); the maca-ginseng water decoction can obviously improve the number of mouse antibody-producing cells (P is less than 0.01) at high dose. The results show that the maca-ginseng water decoction can improve the mouse mononuclear-macrophage function, the cellular immune function and the humoral immune function. The composition has immunity enhancing effect.
According to the invention, the extracted and purified extract is further subjected to the test, and the extract achieves better effect, particularly better than each group of the water decoction of the composition, and has unexpected technical effect.
It should be understood that the above-mentioned teaching of the present invention can be read, and the equivalent changes and modifications made according to the claims of the present invention should be covered by the present invention.
Claims (6)
1. The traditional Chinese medicine composition for enhancing immunity is characterized in that raw material medicines of the traditional Chinese medicine composition mainly comprise maca and ginseng in a weight ratio of: the ratio of the maca to the ginseng is 1-6: 1, or the ratio of the maca to the ginseng is 2-5: 1, or the ratio of the maca to the ginseng is 2-4: 1, or the ratio of the maca to the ginseng is 3-6: 1.
2. The traditional Chinese medicine composition for enhancing immunity according to claim 1, wherein raw materials of the traditional Chinese medicine composition comprise maca and ginseng in a weight ratio of: maca to ginseng = 2: 1, or maca to ginseng = 3: 1, or maca to ginseng = 4: 1, or maca to ginseng = 5: 1, or maca to ginseng = 6: 1.
3. The composition for enhancing immunity according to claim 1, wherein the main raw materials comprise maca and ginseng, and the weight ratio of the maca to the ginseng is as follows: maca to ginseng = 4: 1.
4. A method for preparing the composition for enhancing immunity according to claims 1 to 3, comprising the steps of:
1) Crushing dried maca and ginseng to obtain coarse maca and ginseng powder;
2) Weighing the coarse maca powder and the ginseng powder according to the ratio of 4: 1, adding purified water, wherein the ratio of water to coarse powder is = 8: 1, decocting for hours, and filtering to obtain filtrate;
3) Adding purified water into the filter residue obtained in the step 2 according to the proportion in the step 2, continuously decocting for 1 hour, and filtering to obtain a filtrate;
and (3) combining the filtrates obtained in the step 2) and the step 3), and concentrating to obtain the concentrated solution of the composition for enhancing immunity.
5. The composition for enhancing immunity according to claims 1-3, wherein the composition is in the form of an oral preparation, such as a tablet, pill.
6. Use of the composition for enhancing immunity according to claims 1-3 for the preparation of a composition for enhancing immunity.
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| CN107050089A (en) * | 2017-03-29 | 2017-08-18 | 新疆旺源生物科技集团有限公司 | It is a kind of to significantly increase maca composition of immunity function and preparation method thereof |
| CN110169483A (en) * | 2019-04-23 | 2019-08-27 | 广东润源中天生物科技有限公司 | It is a kind of to contain maca, the pressed candy of ginseng and preparation method thereof |
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| CN107050089A (en) * | 2017-03-29 | 2017-08-18 | 新疆旺源生物科技集团有限公司 | It is a kind of to significantly increase maca composition of immunity function and preparation method thereof |
| CN110169483A (en) * | 2019-04-23 | 2019-08-27 | 广东润源中天生物科技有限公司 | It is a kind of to contain maca, the pressed candy of ginseng and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 神农须: "人参玛咖茶有什么效果，人参玛卡有副作用吗", pages 1 - 2, Retrieved from the Internet <URL:https://www.dongbeiw.com/rsgx/2762.html> * |
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