CN115141691A - Composition for reducing irritation of detergent and application thereof - Google Patents
Composition for reducing irritation of detergent and application thereof Download PDFInfo
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- CN115141691A CN115141691A CN202210724775.8A CN202210724775A CN115141691A CN 115141691 A CN115141691 A CN 115141691A CN 202210724775 A CN202210724775 A CN 202210724775A CN 115141691 A CN115141691 A CN 115141691A
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- detergent
- irritation
- skin
- alkyl glycoside
- sodium lactate
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- 239000003599 detergent Substances 0.000 title claims abstract description 92
- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 230000007794 irritation Effects 0.000 title abstract description 57
- 229920000570 polyether Polymers 0.000 claims abstract description 65
- 239000004721 Polyphenylene oxide Substances 0.000 claims abstract description 64
- 229930182470 glycoside Natural products 0.000 claims abstract description 55
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims abstract description 54
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims abstract description 54
- 239000001540 sodium lactate Substances 0.000 claims abstract description 54
- 229940005581 sodium lactate Drugs 0.000 claims abstract description 54
- 235000011088 sodium lactate Nutrition 0.000 claims abstract description 54
- -1 alkyl glycoside sulfosuccinate ester salts Chemical class 0.000 claims abstract description 53
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 48
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 17
- 230000002195 synergetic effect Effects 0.000 abstract description 13
- 239000004094 surface-active agent Substances 0.000 abstract description 10
- 230000002411 adverse Effects 0.000 abstract description 7
- 239000000126 substance Substances 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 55
- 230000000052 comparative effect Effects 0.000 description 48
- 230000003020 moisturizing effect Effects 0.000 description 21
- 238000012360 testing method Methods 0.000 description 18
- 235000011187 glycerol Nutrition 0.000 description 16
- 229920002494 Zein Polymers 0.000 description 12
- 239000005019 zein Substances 0.000 description 12
- 229940093612 zein Drugs 0.000 description 12
- 239000000047 product Substances 0.000 description 10
- 230000006872 improvement Effects 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000011734 sodium Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- 210000000434 stratum corneum Anatomy 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 239000003945 anionic surfactant Substances 0.000 description 6
- 150000002338 glycosides Chemical class 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 5
- 238000004132 cross linking Methods 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 239000002736 nonionic surfactant Substances 0.000 description 5
- 238000009499 grossing Methods 0.000 description 4
- 230000036571 hydration Effects 0.000 description 4
- 238000006703 hydration reaction Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 229910044991 metal oxide Inorganic materials 0.000 description 4
- 150000004706 metal oxides Chemical class 0.000 description 4
- 206010040880 Skin irritation Diseases 0.000 description 3
- 229920002385 Sodium hyaluronate Polymers 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 210000000245 forearm Anatomy 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- 229940010747 sodium hyaluronate Drugs 0.000 description 3
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 3
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000004909 Moisturizer Substances 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 231100000245 skin permeability Toxicity 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- WBIQQQGBSDOWNP-UHFFFAOYSA-N 2-dodecylbenzenesulfonic acid Chemical compound CCCCCCCCCCCCC1=CC=CC=C1S(O)(=O)=O WBIQQQGBSDOWNP-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 238000007696 Kjeldahl method Methods 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940060296 dodecylbenzenesulfonic acid Drugs 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000011086 high cleaning Methods 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- JPMIIZHYYWMHDT-UHFFFAOYSA-N octhilinone Chemical compound CCCCCCCCN1SC=CC1=O JPMIIZHYYWMHDT-UHFFFAOYSA-N 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/34—Organic compounds containing sulfur
- C11D3/3472—Organic compounds containing sulfur additionally containing -COOH groups or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3707—Polyethers, e.g. polyalkyleneoxides
Abstract
The invention relates to the field of daily chemicals and discloses a composition for reducing irritation of a detergent and application thereof. The composition comprises the following components: alkyl glycoside sulfosuccinate ester salts, glycerol polyether, sodium lactate. According to the invention, the three specific components are compounded, the alkyl glycoside sulfosuccinate salt is utilized to promote the common surfactant in the detergent to be washed away by water, and the synergistic effect between the glyceryl polyether and the sodium lactate and the synergistic effect between the sodium lactate and the glyceryl polyether and the alkyl glycoside sulfosuccinate salt are utilized, so that the irritation of the conventional detergent can be remarkably reduced, the adverse effect of the conventional detergent on the skin can be reduced, and the technical problem that the irritation of the conventional detergent is difficult to remarkably reduce by using the existing irritation improving component is solved.
Description
Technical Field
The invention relates to the field of daily chemicals, in particular to a composition for reducing irritation of a detergent and application thereof.
Background
In recent years, with the continuous development of economy, the living standard of people is rapidly improved, the requirements of consumers on the quality of products are higher and higher, and the products are not limited to the basic functions of the products, for example, detergents such as laundry detergent, washing powder and the like are required to have strong detergency, moderate and no stimulation; when personal washing and protecting products such as shower gel, shampoo, liquid soap and the like are purchased, the mildness of the products can be considered preferentially, and the products with skin-protecting components or effects are more popular.
At present, hand-washing detergents (such as laundry detergent, washing powder, liquid detergent and the like) on the market are various, and due to low price and strong cleaning power, anionic surfactants represented by alkyl polyoxyethylene ether sodium sulfate and sodium alkyl benzene sulfonate are mainly used as effective components. However, they are highly irritating to the skin, and frequent contact with the skin for a long period of time causes changes in the properties of the stratum corneum and the epidermis of the skin, leading to problems such as skin roughness, dryness, itching, and redness. Part of the products are introduced with nonionic surfactants as effective components to reduce the dosage of anionic surfactants, thereby reducing the skin irritation of the detergent. Some products reduce skin irritation by lowering the pH. In general, however, these strategies have had limited effectiveness, and current hand-wash detergents are still relatively irritating to the skin and tend to cause skin irritation in sensitive skin consumers.
Patent application No. CN202110809339.6 discloses a detergent composition having both low irritancy, high cleaning power and low temperature stability, comprising: (a) an anionic surface active agent; (b) amine oxide amphoteric surfactants; (c) a nonionic surfactant; (d) a irritation-improving ingredient; the irritation-improving component is at least one of sodium lactate, sodium pyrrolidone carboxylate, and sodium hyaluronate, and preferably sodium lactate. Although the irritation-improving ingredient used in this patent can reduce the irritation of the detergent to some extent, the effect is limited, and only when used in combination with a specific detergent system using the component (b) can the detergent as a whole exhibit low irritation, and when used in a conventional detergent formulation, the detergent still has high irritation.
Disclosure of Invention
In order to solve the technical problem that the irritation of the detergent is difficult to obviously reduce by the existing irritation improving components, the invention provides a composition for reducing the irritation of the detergent and application thereof. According to the invention, the alkyl glycoside sulfosuccinate ester salt, the glyceryl polyether and the sodium lactate are compounded, so that the irritation of the conventional detergent can be obviously reduced, and the adverse effect on the skin is reduced.
The specific technical scheme of the invention is as follows:
in a first aspect, the present invention provides the use of an alkyl glycoside sulfosuccinate salt in the preparation of an adjunct for reducing the irritancy of a detergent.
The irritation of hand-washing detergents is a key factor that causes skin changes and affects the use experience. Anionic surfactants such as sodium alkyl benzene sulphonate can penetrate the stratum corneum membrane and destroy its integrity by degreasing, which can lead to rough and even painful skin surface texture. Therefore, irritation is reduced, and adverse effects on the skin can be significantly reduced.
Theoretical analysis and experimental research show that the alkyl glycoside sulfosuccinate can be used for reducing the irritation of the detergent, and the mechanism is as follows: the alkyl glycoside sulfosuccinate salt contains a plurality of strong hydrophilic groups, has strong hydrophilicity, is easier to exist in water and then is washed away in the washing process, and is not easy to be placed on the skin. And because of the structural characteristics, the detergent has the characteristics of both non-ions and anions, and has good affinity with an anionic surfactant and a non-ionic surfactant which are commonly used in detergents according to the principle of similar intermiscibility, the anionic surfactant and the non-ionic surfactant which are commonly used in detergents can be easily washed away by water, so that the amount of the residual surfactant on the skin is reduced, and the irritation is greatly reduced.
Preferably, the alkyl glycoside sulfosuccinate salt has the formula:
wherein R is C 8～16 N is 1.0 to 1.4.
Further, in the alkyl glycoside sulfosuccinate ester salt, R is C 12～16 Alkyl group of (1).
In the alkyl glycoside sulfosuccinate ester salt, under the influence of strong hydrophilic groups, the lipophilic ability of the alkyl glycoside sulfosuccinate ester salt needs to be properly balanced, so that the alkyl glycoside sulfosuccinate ester salt can better affinity other surfactants in a detergent, thereby realizing better elution effect and reducing the irritation of the detergent, and therefore, when the alkyl chain is at C 8～16 When the alkyl chain adopts C, the effect is better 12～16 In this case, the effect of reducing the irritation of the detergent can be further improved.
When the polymerization degree (n) of the glycoside is between 1.0 and 1.4, the distribution range is narrow, and the influence is relatively small.
In a second aspect, the present invention provides a composition for reducing the irritancy of detergents, the composition comprising the following components: alkyl glycoside sulfosuccinate ester salt, glycerol polyether and sodium lactate.
According to the invention, through compounding the three specific components, the irritation of the conventional detergent can be obviously reduced, the adverse effect on skin is reduced, and the skin feel of the detergent after use is improved, specifically:
1) Addition of alkyl glycoside sulfosuccinate salt:
the alkyl glycoside sulfosuccinate ester salt can promote the common anionic surfactant and nonionic surfactant in the detergent to be washed away by water, reduce the residual quantity on the skin and further reduce the irritation of the detergent.
2) Compounding sodium lactate and glycerol polyether:
maintaining the proper water content in the stratum corneum layer of the skin is important to its function. If the outer layer of the stratum corneum does not have sufficient moisture to remain normally flexible, the skin will scale and become itchy, with reduced skin permeability. If the outer layer of the skin is too much water, it causes the stratum corneum to absorb 3-5 times its own weight of bound water, causing the skin to swell and wrinkle, while the skin permeability increases. Therefore, in addition to reducing irritation, there is a need for ingredients that help the stratum corneum maintain its barrier and water retention functions.
The sodium lactate is a component occupying one fourth of the stratum corneum of human skin, and can reduce the irritation of a detergent and bring a certain moisturizing effect when added into the detergent; the glyceryl polyether is used as a humectant, and can improve the soft and smooth texture of skin. However, the team of the present invention finds, through theoretical analysis and experimental research, that in the detergent, when sodium lactate or glyceryl polyether is used alone, the effect of reducing the irritation of the detergent is limited, and when sodium lactate and glyceryl polyether are compounded, a synergistic effect of "1+1 >" 2 "can be generated, and the presumed mechanism is as follows: cross-linking hydrogen bonds can be formed among the glyceryl polyether, the sodium lactate and water molecules, a hydration film is formed on the surface of the skin, water volatilization is prevented, the moisturizing effect is better exerted, and smoothness is also brought.
No combination of any moisturizer with sodium lactate allowed a comparable synergistic effect to glyceryl polyether to be achieved, because: firstly, a cross-linking hydrogen bond is formed to form a latticed structure, so that the water-retaining effect is good, and the moisture retention is realized; the glycerin polyether is secondarily formed into a film layer structure on the skin surface, so that the integral water locking and moisture preservation can be realized, and the glycerin polyether is based on the unique branched long polyether chain structure, so that the skin surface can be comprehensively and uniformly covered, and the smoothness is brought while the moisture preservation is realized. Conventional other moisturizers, such as sodium pyrrolidone carboxylate, sodium hyaluronate and the like, do not form similar structures, so that the same synergistic effect is not achieved.
3) Compounding sodium lactate, glyceryl polyether and alkyl glycoside sulfosuccinate salt:
the team of the invention finds that when only sodium lactate and glyceryl polyether are added into a detergent, the detergent does not show obvious effect of moisturizing and smoothing skin, but after the sodium lactate and the glyceryl polyether are compounded with alkyl glycoside sulfosuccinate ester salt, a synergistic effect can be generated to obviously reduce the irritation of the detergent, and the detergent has the characteristic of moisturizing and smoothing skin, and the presumed mechanism is as follows: when the alkyl glycoside sulfosuccinate ester salt is not added, more components commonly used in detergents, such as surfactants and auxiliaries, remain on the skin, and the formation of a cross-linking hydrogen bond structure and a hydration film layer structure among the glyceryl polyether, the sodium lactate and water molecules is destroyed.
Preferably, the mass ratio of the glyceryl polyether to the sodium lactate is (0.1-1): (0.1-1).
Based on the synergistic action mechanism between the glyceryl polyether and the sodium lactate, the invention discovers that when the ratio of the glyceryl polyether to the sodium lactate is too high or too low, the effects of reducing the irritation of the detergent and improving the skin feel of the detergent after use are poor, and specifically: when the relative amount of the glyceryl polyether is too small, the smooth feeling is weakened, which is probably because a certain amount of the glyceryl polyether is required for the formation of a hydration film layer; when the relative amount of sodium lactate is too small, the irritation-reducing effect and the moisturizing effect are reduced, and it is presumed that the moisturizing effect of sodium lactate is superior to that of glycerin polyether.
Preferably, the ratio of the total mass of the glyceryl polyether and the sodium lactate to the mass of the alkyl glycoside sulfosuccinate salt is (0.2-3): (0.3-3).
The invention is based on a synergistic action mechanism between the glyceryl polyether and sodium lactate and the alkyl glycoside sulfosuccinate salt, and finds that when the ratio of the total mass of the glyceryl polyether and the sodium lactate to the mass of the alkyl glycoside sulfosuccinate salt is too large or too small, the effects of reducing the irritation of a detergent and improving the skin feel of the detergent after use are poor, specifically: when the relative amount of the glyceryl polyether and the sodium lactate is too small, although the irritation is still obviously reduced, the moisturizing effect and the smooth feeling are obviously reduced, on one hand, the better effect is realized because the amount of the glyceryl polyether and the sodium lactate is insufficient, on the other hand, the excessive alkyl glycoside sulfosuccinate salt can also elute part of the glyceryl polyether and the sodium lactate, so that the residual amount on the skin is less, and the effect is less ideal; when the relative amount of the alkyl glycoside sulfosuccinate salt is too small, the decrease in irritation is not significant, presumably because it is insufficient to significantly reduce irritation caused by usual detergent ingredients remaining on the skin, such as sodium alkylbenzenesulfonate, etc., and the relative amounts of glycerin polyether adsorbed on the skin and sodium lactate are decreased, and the moisturizing effect and the smoothing effect are also not significant.
Preferably, the alkyl glycoside sulfosuccinate salt has the following formula:
wherein R is C 8～16 N is 1.0 to 1.4.
Further, in the alkyl glycoside sulfosuccinate ester salt, R is C 12～16 The alkyl group of (1).
Preferably, the glyceryl polyether comprises one or more of glyceryl polyether-12, glyceryl polyether-18 and glyceryl polyether-26.
When the three glyceryl polyethers are selected, the irritation of the detergent can be reduced to a greater extent, and the skin feeling after the detergent is used can be improved, because: the polyether chain length is moderate, and the polyether chain can better form a cross-linking hydrogen bond with sodium lactate and water to form a hydration film, otherwise, if the polyether chain length is too short, the cross-linking hydrogen bond network structure is possibly incomplete, and if the polyether chain length is too long, the hydrophilicity is possibly too strong, and the residual quantity on skin is insufficient.
In a third aspect, the invention provides the use of the composition as an adjunct in reducing the irritancy of detergents.
Compared with the prior art, the invention has the following advantages:
(1) According to the invention, the three specific components are compounded, the alkyl glycoside sulfosuccinate salt is used for promoting the common surfactant in the detergent to be washed away by water, and the synergistic effect between the glyceryl polyether and the sodium lactate and the synergistic effect between the sodium lactate and the alkyl glycoside sulfosuccinate salt are used, so that the irritation of the conventional detergent can be obviously reduced, the adverse effect of the conventional detergent on the skin can be reduced, and the skin feel of the detergent after use can be improved;
(2) By controlling the proportion of the three components, good synergistic effects can be generated between the glyceryl polyether and the sodium lactate and between the glyceryl polyether, the sodium lactate and the alkyl glycoside sulfosuccinate ester salt, the irritation of the detergent is effectively reduced, and the skin feel of the detergent after use is improved.
Detailed Description
The present invention will be further described with reference to the following examples.
General examples
A composition for reducing detergent irritancy, comprising the following components: alkyl glycoside sulfosuccinate ester salt, glycerol polyether and sodium lactate. The mass ratio of the glyceryl polyether to the sodium lactate is (0.1-1): (0.1-1). The ratio of the total mass of the glycerol polyether and the sodium lactate to the mass of the alkyl glycoside sulfosuccinate ester salt is (0.2-3): (0.3-3).
The alkyl glycoside sulfosuccinate salt has the following general formula:
wherein R is C 8～16 Alkyl (more preferably C) 12～16 And n is 1.0 to 1.4.
The glycerol polyether comprises one or more of glycerol polyether-12, glycerol polyether-18 and glycerol polyether-26.
Examples 1 to 10 and comparative examples 1 to 6
A composition for reducing detergent irritancy is prepared according to the following steps:
(1) Weighing alkyl glycoside sulfosuccinate ester salt, glycerol polyether and sodium lactate according to the mass ratio in tables 1-3;
(2) Mixing and uniformly stirring alkyl glycoside sulfosuccinate salt and sodium lactate to obtain a primary blend;
(3) And adding the glyceryl polyether into the primary blend, and uniformly stirring to obtain the composition for reducing the irritation of the detergent.
In tables 1 to 3, "-" indicates the amount added of 0; APG-SS1, APG-SS2, APG-SS3 and APG-SS4 represent 4 different alkyl glycoside sulfosuccinate ester salts, and the structural general formulas are as follows:
the 4 alkyl glycoside sulfosuccinate salts differ as follows:
APG-SS1: sodium alkyl glycoside sulfosuccinate, R is C 8～10 Alkyl, n is 1.0;
APG-SS2: sodium alkyl glycoside sulfosuccinate, R is C 12～14 Alkyl, n is 1.2;
APG-SS3: sodium alkyl glycoside sulfosuccinate, R is C 8～16 Alkyl, n is 1.4;
APG-SS4: sodium alkyl glycoside sulfosuccinate, R is C 12～16 Alkyl, n is 1.4.
TABLE 1
TABLE 2
TABLE 3
Application examples 1 to 10 and comparative application examples 1 to 6
The compositions prepared in examples 1 to 10 and comparative examples 1 to 6 were taken and formulated into detergents of application examples 1 to 10 and comparative application examples 1 to 6, respectively, according to the following procedure:
(1) Weighing the following raw materials in percentage by mass: 8% of dodecyl benzene sulfonic acid, 4% of polyethoxylated fatty alcohol, 2% of ethoxylated alkyl sodium sulfate, 0.5% of triethanolamine, 0.6% of trisodium citrate dihydrate, 0.1% of kathon preservative and 81.8% of deionized water; uniformly mixing to obtain a primary mixture;
(2) The compositions prepared in examples 1 to 10 and comparative examples 1 to 6 were added to the initial mixture, respectively, and the mass ratio of the initial mixture to the composition was 97.
Comparative application example 7
The difference between the application example and the application example 1 is that the composition for reducing the irritation of the detergent is replaced by the deionized water in the step (2), namely, the composition for reducing the irritation of the detergent is not added to the detergent of the application example.
Test example 1: irritation test
The samples to be tested (detergents of application examples 1 to 10 and comparative application examples 1 to 7) were formulated into solutions with a mass fraction of 10 wt%. Taking 50mL, adding 2g of zein, stirring for 2h at 25 ℃, observing once every 10min, and adding the zein according to the situation to ensure that the solution contains enough undissolved zein. Then standing and filtering, and measuring the mass fraction (A) of nitrogen in the filtrate by a micro Kjeldahl method. Taking another 50mL of the detergent solution without adding the zein to carry out a blank experiment, and measuring the mass fraction (B) of nitrogen in the detergent solution without adding the zein.
Zein value = a-B, zein value is expressed in mg (or g) of nitrogen contained in the solution, N mg (g)/L.
The irritancy of surfactants can be classified by Zein number into 3:
(1) Surfactants with Zein values greater than N4 g/L solution are "strongly irritating".
(2) The surfactant with Zein value in N2-4 g/L solution is low in irritation.
(3) Surfactants having a Zein value of less than N2 g/L solution are "non-irritating".
The test results are shown in Table 4.
TABLE 4
| Detergent composition | Composition comprising a metal oxide and a metal oxide | Zein value of N g/L |
| Application example 1 | Example 1 | 1.57 |
| Application example 2 | Example 2 | 1.32 |
| Application example 3 | Example 3 | 2.91 |
| Application example 4 | Example 4 | 2.83 |
| Application example 5 | Example 5 | 4.54 |
| Application example 6 | Example 6 | 2.56 |
| Application example 7 | Example 7 | 7.26 |
| Application example 8 | Example 8 | 1.22 |
| Application example 9 | Example 9 | 1.79 |
| Application example 10 | Example 10 | 1.81 |
| Comparative application example 1 | Comparative example 1 | 7.62 |
| Comparative application example 2 | Comparative example 2 | 4.53 |
| Comparative application example 3 | Comparative example 3 | 4.25 |
| Comparative application example 4 | Comparative example 4 | 3.4 |
| Comparative application example 5 | Comparative example 5 | 4.8 |
| Comparative application example 6 | Comparative example 6 | 4.6 |
| Comparative application example 7 | - | 8.58 |
Test example 2: moisture retention effect
According to the evaluation guideline of moisturizing efficacy of cosmetics, at least 30 healthy volunteers are selected, a test instrument is a Corneometer CM825, and a test place ensures constant temperature and constant humidity, the temperature is 20-22 ℃, and the relative humidity is 40-60%. The test subject needs to wash the inner sides of the forearms of both hands, and measurement area marks are made on the inner sides of the forearms of both hands of the test subject after cleaning, and each test area is 3cm multiplied by 3cm in area. Before the test, the patient sits statically in a constant-temperature and constant-humidity room for at least 30min, can not drink water, exposes the forearm, avoids touching and keeps relaxed. The moisture content (MMV value) of the designated area inside the left and right arms of the subject was measured and recorded. The initial values of the test areas were measured, and then 0.2wt% of the aqueous solution of the test sample (detergents of application examples 1 to 10 and comparative application examples 1 to 7) was uniformly applied to the test areas with a latex finger cot, and the single application amount was 2mg/cm 2 After 20 minutes of action, the test area was rinsed with clean water for 30 seconds and the surface was blotted dry with a paper towel. The MMV values of the smeared (test) and blank (blank) areas were measured 2 hours before and after sample use, respectively. The tests of the same volunteer were performed by the same measuring staff. The results of the experiment are shown in Table 5.
TABLE 5
1 Blank group: no detergent is smeared.
Test example 3: the post-use skin smoothness test 30 subjects evaluated the feeling of use of the product with the evaluation parameters: skin smoothness. The score is 1-4, with higher scores representing smoother skin. The index scores of the subjects after using the products of application examples 1 to 10 and comparative application examples 1 to 7 were counted, and the results are shown in table 6.
TABLE 6
| Detergent composition | Composition comprising a metal oxide and a metal oxide | Average score |
| Application example 1 | Example 1 | 2.8 |
| Application example 2 | Example 2 | 3.5 |
| Application example 3 | Example 3 | 2.4 |
| Application example 4 | Example 4 | 1.5 |
| Application example 5 | Example 5 | 1.8 |
| Application example 6 | Example 6 | 1.7 |
| Application example 7 | Example 7 | 1.7 |
| Application example 8 | Example 8 | 3.7 |
| Application example 9 | Example 9 | 1.3 |
| Application example 10 | Example 10 | 1.6 |
| Comparative application example 1 | Comparative example 1 | 1.5 |
| Comparative application example 2 | Comparative example 2 | 1.3 |
| Comparative application example 3 | Comparative example 3 | 1.5 |
| Comparative application example 4 | Comparative example 4 | 1.5 |
| Comparative application example 5 | Comparative example 5 | 1.3 |
| Comparative application example 6 | Comparative example 6 | 1.4 |
| Comparative application example 7 | - | 1.4 |
Data analysis and conclusions:
(1) Comparative application example 7 detergent without composition added; in application example 2 and comparative application examples 1 and 2, the total amounts of the alkyl glycoside sulfosuccinate salt, sodium lactate, and glycerin polyether were the same, and in comparative application example 1, the alkyl glycoside sulfosuccinate salt was not added, and in comparative application example 2, the sodium lactate and glycerin polyether were not added. As can be seen from tables 4 to 6: the irritation of comparative application examples 1 and 2 is significantly higher than that of application example 2, and the moisturizing effect and the smoothness of the skin after use are significantly lower than those of application example 2; also, the irritation, moisturizing effect, and skin smoothness after use of comparative application example 1 were close to those of comparative application example 7. And (4) conclusion: the alkyl glycoside sulfosuccinate ester salt can effectively reduce the irritation of the detergent; when sodium lactate and glyceryl polyether are used alone, obvious moisturizing and skin smoothing effects are difficult to exert; the alkyl glycoside sulfosuccinate salt can exert the synergistic effect of ' 1+1> ' 2 ' with the sodium lactate and the glycerol polyether, and after the three are compounded, the irritation of the detergent can be reduced to a greater extent, and the skin feel of the detergent after use can be improved.
(2) In application example 2 and comparative application examples 3 and 4, the total amounts of sodium lactate and glyceryl polyether were the same, and sodium lactate was not added in comparative application example 3, and glyceryl polyether was not added in comparative application example 4. As can be seen from tables 4 to 6: the improvement effects on the irritation, moisturizing effect and skin smoothness after use of comparative application examples 3 and 4 were significantly lower than that of application example 2. And (4) conclusion: the sodium lactate and the glyceryl polyether can exert the synergistic effect of ' 1+1> ' 2 ', and after the two are compounded, the irritation of the detergent can be reduced to a greater extent, and the skin feel of the detergent after use can be improved.
(3) In application examples 1 and 4, the mass ratio of the glyceryl polyether to the sodium lactate is respectively 0.1; in application examples 3 and 5, the mass ratio of the glyceryl polyether to the sodium lactate is 1.1 and 1, respectively, and the other raw materials and the preparation method are the same. As can be seen from tables 4 to 6: the improvement effects of application example 1 on the irritation, moisturizing effect and smoothness of the skin after use are significantly higher than those of application example 4; the improvement effects of application example 3 on the irritation, moisturizing effect and smoothness of the skin after use were significantly higher than that of application example 5. And (4) conclusion: when the mass ratio of the glyceryl polyether to the sodium lactate is (0.1-1): when the mass ratio is in the range of (0.1 to 1), the irritation of the detergent can be reduced to improve the skin feeling after the use of the detergent, and when the mass ratio is too large or too small, the effect is adversely affected.
(4) In application examples 1 and 6, the mass ratio of the total mass of the glyceryl polyether and the sodium lactate to the mass of the alkyl glycoside sulfosuccinate ester salt is 1; in application examples 3 and 7, the ratios were 1. As can be seen from tables 4 to 6: the improvement effects of application example 1 on the irritation, moisturizing effect and smoothness of the skin after use were significantly higher than that of application example 6; the improvement effect of application example 3 on the irritation, moisturizing effect and smoothness of the skin after use was significantly higher than that of application example 7. And (4) conclusion: when the ratio of the total mass of the glyceryl polyether and the sodium lactate to the mass of the alkyl glycoside sulfosuccinate ester salt is (0.2-3): (0.3 to 3) can reduce the irritation of the detergent and improve the skin feeling after the use of the detergent, and when the mass ratio is too large or too small, the effect is adversely affected.
(5) In application examples 2 and 8, the number of carbon atoms in the alkyl group R in the alkyl glycoside sulfosuccinate salt is 8 to 16 and 12 to 16, respectively. As can be seen from tables 4 to 6: the effect of application example 8 on improvement of irritation, moisturizing effect and smoothness of skin after use was significantly higher than that of application example 2. And (4) conclusion: when the alkyl group in the alkyl glycoside sulfosuccinate salt adopts C 8～16 When C is used, the irritation of the detergent can be effectively reduced, and the skin feeling after the detergent is used can be improved 12～16 When the method is used, better effect can be produced.
(6) The application examples 1 and 9 respectively adopt glyceryl polyether-12 and glyceryl polyether-8, and the other raw materials and the preparation method are the same; in application examples 2 and 10, glyceryl polyether-26 and glyceryl polyether-31 are respectively adopted, and the other raw materials and the preparation method are the same. As can be seen from tables 4 to 6: the improvement effects of application example 1 on the irritation, moisturizing effect and smoothness of the skin after use were significantly higher than that of application example 9; the improvement effects of application example 2 on the irritation, moisturizing effect and smoothness of the skin after use were significantly higher than that of application example 10. And (4) conclusion: too long or too short polyether chains in the glyceryl polyether cause poor effects of reducing irritation of the detergent and improving skin feel after the detergent is used.
(7) In application example 2, comparative application examples 5 and 6, glyceryl polyether, sodium pyrrolidone carboxylate and sodium hyaluronate were used, respectively. As can be seen from tables 4 to 6: application example 2 was significantly higher in the improvement effect on the irritation, moisturizing effect and smoothness of the skin after use than comparative application examples 5 and 6.
The raw materials and equipment used in the invention are common raw materials and equipment in the field if not specified; the methods used in the present invention are conventional in the art unless otherwise specified.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and all simple modifications, alterations and equivalents of the above embodiments according to the technical spirit of the present invention are still within the protection scope of the technical solution of the present invention.
Claims (10)
1. Use of an alkyl glycoside sulfosuccinate salt for the preparation of an auxiliary which reduces the irritancy of a detergent.
2. Use according to claim 1, wherein the alkyl glycoside sulfosuccinate salt has the formula:
wherein R is C 8～16 N is 1.0 to 1.4.
3. The use according to claim 2, wherein in the alkyl glycoside sulfosuccinate salt, R is C 12～16 The alkyl group of (1).
4. A composition for reducing detergent irritancy, comprising the following components: alkyl glycoside sulfosuccinate ester salt, glycerol polyether and sodium lactate.
5. The composition according to claim 4, wherein the mass ratio of the glyceryl polyether to the sodium lactate is (0.1-1): (0.1-1).
6. The composition according to claim 5, wherein the ratio of the total mass of the glyceryl polyether and the sodium lactate to the mass of the alkyl glycoside sulfosuccinate salt is (0.2-3): (0.3-3).
7. The composition according to claim 4 or 6, wherein the alkyl glycoside sulfosuccinate salt has the formula:
wherein R is C 8～16 N is 1.0 to 1.4.
8. The composition of claim 7 wherein in the alkyl glycoside sulfosuccinate salt, R is C 12～16 Alkyl group of (1).
9. The composition of claim 4 or 5, wherein the glyceryl polyether comprises one or more of glyceryl polyether-12, glyceryl polyether-18 and glyceryl polyether-26.
10. Use of a composition according to any of claims 4 to 9 as an adjunct in reducing the irritativeness of detergents.
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| US5997758A (en) * | 1995-06-01 | 1999-12-07 | Societe D'exploitation De Produits Pour Les Industries Chimiques - Seppic | Foaming composition and use thereof as a fire-extinguishing foam |
| CN104257524A (en) * | 2014-09-19 | 2015-01-07 | 江苏万淇生物科技有限公司 | Shampoo containing alkyl ethoxy polyglycosides |
| WO2015089716A1 (en) * | 2013-12-16 | 2015-06-25 | L'oreal | Composition comprising cyclodextrin and its derivative, anionic surfactant and polyalkylene glycol ether of alcohol, and its use thereof |
| CN113507917A (en) * | 2019-02-04 | 2021-10-15 | 西姆莱斯有限公司 | Active agent for skin and hair care having physicochemical modification property |
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- 2022-06-23 CN CN202210724775.8A patent/CN115141691A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5997758A (en) * | 1995-06-01 | 1999-12-07 | Societe D'exploitation De Produits Pour Les Industries Chimiques - Seppic | Foaming composition and use thereof as a fire-extinguishing foam |
| WO2015089716A1 (en) * | 2013-12-16 | 2015-06-25 | L'oreal | Composition comprising cyclodextrin and its derivative, anionic surfactant and polyalkylene glycol ether of alcohol, and its use thereof |
| CN104257524A (en) * | 2014-09-19 | 2015-01-07 | 江苏万淇生物科技有限公司 | Shampoo containing alkyl ethoxy polyglycosides |
| CN113507917A (en) * | 2019-02-04 | 2021-10-15 | 西姆莱斯有限公司 | Active agent for skin and hair care having physicochemical modification property |
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