CN115138416A - Medical micro-fluidic chip liquid drop collection device - Google Patents
Medical micro-fluidic chip liquid drop collection device Download PDFInfo
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- CN115138416A CN115138416A CN202210691800.7A CN202210691800A CN115138416A CN 115138416 A CN115138416 A CN 115138416A CN 202210691800 A CN202210691800 A CN 202210691800A CN 115138416 A CN115138416 A CN 115138416A
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- supporting
- plate
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- lifting
- negative pressure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
Abstract
The invention provides a medical micro-fluidic chip liquid drop collecting device which comprises a base, wherein a supporting frame is arranged on the upper surface of the base, a chip pressing mechanism is arranged at the top end of the supporting frame, a collecting box supporting mechanism is arranged at the bottom end of the supporting frame, and a negative pressure fixing mechanism is arranged between the chip pressing mechanism and the collecting box supporting mechanism; the support frame comprises two hollow support rods arranged on the upper surface of the base, piston rods penetrating through the hollow support rods and lifting rods connected with the top ends of the two piston rods; the negative pressure fixing mechanism comprises a fixing plate arranged on the hollow support rod shell in a penetrating mode, a through hole arranged on the fixing plate shell, a supporting plate arranged on the inner wall of the hole body of the through hole, and negative pressure adsorption components arranged on two sides of the supporting plate. The invention can quickly install the liquid drop collecting box and the micro-fluidic chip, can ensure that the liquid drop collecting box and the micro-fluidic chip are tightly connected, and improves the collecting effect of the liquid drop collecting box.
Description
Technical Field
The invention mainly relates to the technical field of medical micro-fluidic chips, in particular to a droplet collecting device of a medical micro-fluidic chip.
Background
The micro-fluidic chip system can complete the functions of pretreatment, micro-analysis, mixing or separation and the like by accurately controlling micro-fluid in a chip channel, and is receiving more and more attention in the fields of biological, chemical and medical analysis.
According to a droplet collecting device based on a microfluidic chip provided by patent document with application number CN201720041733.9, the collecting device comprises a base, pillars are fixedly connected to the left and right sides of the top of the base, droplet collecting boxes are fixedly connected to the top of the base, fixed blocks are fixedly connected to the left and right sides of the droplet collecting boxes, and outer walls of the two groups of fixed blocks are respectively connected with the left and right side walls of the pillars.
The droplet collecting device adopts the microfluidic chip and the microfluidic tube, so that different droplets can flow in different microfluidic tubes, and the phenomenon of mutual fusion of the droplets in the flow process can not occur.
Disclosure of Invention
The invention mainly provides a medical micro-fluidic chip droplet collecting device which is used for solving the technical problems in the background technology.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a medical micro-fluidic chip droplet collecting device comprises a base, wherein a supporting frame is arranged on the upper surface of the base, a chip pressing mechanism is arranged at the top end of the supporting frame, a collecting box supporting mechanism is arranged at the bottom end of the supporting frame, and a negative pressure fixing mechanism is arranged between the chip pressing mechanism and the collecting box supporting mechanism;
the support frame comprises two hollow support rods arranged on the upper surface of the base, piston rods penetrating through the hollow support rods and lifting rods connected with the top ends of the two piston rods;
the negative pressure fixing mechanism comprises a fixing plate penetrating through the hollow support rod shell, a through hole arranged on the fixing plate shell, a supporting plate arranged on the inner wall of the through hole, and negative pressure adsorption components arranged on two sides of the supporting plate;
the negative pressure adsorption component comprises an air suction pipe arranged on the fixed plate in a penetrating mode, one end of the air suction pipe is arranged on the supporting plate shell in a penetrating mode and provided with two negative pressure adsorption heads, the other end of the air suction pipe is provided with a first one-way valve, and the first one-way valve is connected with the air outlet end of the piston rod.
Furthermore, the structure of the chip pressing mechanism is the same as that of the collecting box supporting mechanism, the chip pressing mechanism comprises lifting plates penetrating the two hollow supporting rods, a first spring abutting against one end, far away from the fixed plate, of each lifting plate and sleeved outside the corresponding hollow supporting rod, and a supporting ring abutting against one side surface, far away from the fixed plate, of each first spring and sleeved on the outer surface of the corresponding hollow supporting rod.
Furthermore, the chip pressing mechanism also comprises a hollow lifting button arranged on the lifting plate shell in a penetrating mode, a second spring arranged on the lower surface of one end, extending to the inner portion of the lifting plate, of the hollow lifting button, and a locking component connected with one end, extending to the inner portion of the lifting plate, of the hollow lifting button.
Furthermore, two limiting holes are sequentially formed in the shell of the hollow supporting rod from top to bottom.
Furthermore, the locking part comprises a slide rail block which is connected with the inner wall of the lifting plate in a sliding mode, a cylindrical pin which is arranged at one end of the slide rail block and is inserted into the limiting hole, and a third spring which is arranged at the other end of the slide rail block, wherein one end, far away from the slide rail block, of the third spring is connected with a support plate, and the support plate is arranged inside the lifting plate.
Furthermore, the locking component also comprises a support leg which is arranged on the lower surface of one end of the hollow lifting button and extends to the inner part of the lifting plate, and the support leg is connected with the sliding rail block in a sliding manner.
Furthermore, a groove is formed in the surface of one side, close to the fixed plate, of the lifting plate, and in the liquid drop collecting box supporting mechanism, the lifting plate in the liquid drop collecting box supporting mechanism limits movement of the liquid drop collecting box through the groove.
Furthermore, rubber pressure pads are arranged on the upper surface and the lower surface of the supporting plate, and in the invention, the supporting plate reduces the clearance between the supporting plate and the microfluidic chip and between the supporting plate and the liquid drop limiting collecting box through the rubber pressure pads.
Furthermore, a second one-way valve is mounted on the outer surface of the piston rod, an air outlet end of the second one-way valve is connected with a vacuum breaking pipe, and an air outlet end of the vacuum breaking pipe is communicated with the air suction pipe.
Furthermore, the two ends of the through hole are provided with clamping grooves, and the through hole adapts to the shapes of the micro-fluidic chip and the limiting liquid drop collecting box through the clamping grooves.
Compared with the prior art, the invention has the beneficial effects that:
firstly, the invention can quickly install the droplet collecting box and the micro-fluidic chip, and can ensure that the droplet collecting box and the micro-fluidic chip are tightly connected, thereby improving the collecting effect of the droplet collecting box, and the invention specifically comprises the following steps: the lifting rod drives the piston rod to exhaust air, so that the negative pressure adsorption head communicated with the piston rod exhausts air, negative pressure is formed between the liquid drop collection box and the micro-fluidic chip and the support plate, the liquid drop collection box and the micro-fluidic chip are adsorbed on the support plate, and the liquid drop collection box and the micro-fluidic chip are tightly connected with the support plate.
Secondly, the locking part is driven by the hollow lifting button to be separated from the hollow supporting rod, so that the hollow supporting rod relieves the limit of the hollow supporting rod on the movement of the lifting plate, the lifting plate is pushed by the energy storage of the first spring through the lifting plate, the lifting plate in the chip pressing mechanism is pressed on the microfluidic chip, the lifting plate in the collecting box supporting mechanism is pressed on the liquid drop collecting box, the liquid drop collecting box and the microfluidic chip are quickly pressed on the supporting plate, and the primary butt joint of the liquid drop collecting box and the microfluidic chip is completed.
The present invention will be explained in detail below with reference to the drawings and specific embodiments.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a top view of the present invention;
FIG. 3 isbase:Sub>A cross-sectional view taken along line A-A of FIG. 2;
FIG. 4 is an enlarged view of the structure of region A in FIG. 3;
FIG. 5 is a schematic structural view of a chip pressing mechanism and a negative pressure fixing mechanism according to the present invention;
FIG. 6 is a schematic view of the lifter plate of the present invention;
FIG. 7 is a schematic structural diagram of a fixing plate according to the present invention;
fig. 8 is a schematic structural view of the support frame of the present invention.
In the figure: 10. a base; 20. a support frame; 21. a hollow support rod; 211. a limiting hole; 22. a piston rod; 23. lifting a pull rod; 30. a chip pressing mechanism; 31. a lifting plate; 311. a groove; 32. a first spring; 33. a support ring; 34. a hollow lifting button; 35. a second spring; 36. a locking member; 361. a cylindrical pin; 362. a slide rail block; 363. a third spring; 364. a support plate; 365. a support leg; 40. a collection box support mechanism; 50. a negative pressure fixing mechanism; 51. a fixing plate; 52. a through hole; 521. a card slot; 53. a support plate; 531. a rubber pressure pad; 54. a negative pressure adsorption component; 541. an air intake duct; 542. a negative pressure adsorption head; 543. a first one-way valve.
Detailed Description
In order to facilitate an understanding of the invention, the invention will now be described more fully hereinafter with reference to the accompanying drawings, in which several embodiments of the invention are shown, but which may be embodied in different forms and not limited to the embodiments described herein, but which are provided so as to provide a more thorough and complete disclosure of the invention.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may be present, and when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present, as the terms "vertical", "horizontal", "left", "right" and the like are used herein for descriptive purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, and the use of such term knowledge in the specification of the invention is for the purpose of describing particular embodiments and is not intended to be limiting of the invention, and the use of the term "and/or" herein includes any and all combinations of one or more of the associated listed items.
In an embodiment, referring to fig. 1 to 8, a medical microfluidic chip droplet collecting device includes a base 10, a supporting frame 20 is installed on an upper surface of the base 10, a chip pressing mechanism 30 is installed at a top end of the supporting frame 20, a collecting box supporting mechanism 40 is installed at a bottom end of the supporting frame 20, and a negative pressure fixing mechanism 50 is installed between the chip pressing mechanism 30 and the collecting box supporting mechanism 40;
the supporting frame 20 comprises two hollow supporting rods 21 arranged on the upper surface of the base 10, piston rods 22 penetrating through the hollow supporting rods 21, and lifting rods 23 connected with the top ends of the two piston rods 22;
the negative pressure fixing mechanism 50 comprises a fixing plate 51 arranged on the shell of the hollow support rod 21 in a penetrating manner, a through hole 52 arranged on the shell of the fixing plate 51, a support plate 53 arranged on the inner wall of the through hole 52, and negative pressure adsorption components 54 arranged on two sides of the support plate 53;
the negative pressure adsorption assembly 54 includes a suction pipe 541 disposed through the fixing plate 51, one end of the suction pipe 541 is disposed through the casing of the supporting plate 53 and is provided with two negative pressure adsorption heads 542, the other end of the suction pipe 541 is provided with a first one-way valve 543, and the first one-way valve 543 is connected with the air outlet end of the piston rod 22.
Specifically, please refer to fig. 1 and 5 again, the structure of the chip pressing mechanism 30 is the same as that of the collecting box supporting mechanism 40, and the chip pressing mechanism 30 includes a lifting plate 31 penetrating the two hollow supporting rods 21, a first spring 32 abutting against one end of the lifting plate 31 far away from the fixing plate 51 and sleeved outside the hollow supporting rods 21, and a supporting ring 33 abutting against one side surface of the first spring 32 far away from the fixing plate 51 and sleeved outside the hollow supporting rods 21;
the chip pressing mechanism 30 further includes a hollow lifting button 34 penetrating the casing of the lifting plate 31, a second spring 35 disposed on the lower surface of one end of the hollow lifting button 34 extending to the interior of the lifting plate 31, and a locking member 36 connected to one end of the hollow lifting button 34 extending to the interior of the lifting plate 31;
it should be noted that, in this embodiment, the first spring 32 provides support for the microfluidic chip through the support ring 33, the lifting plate 31 is charged with energy through the first spring 32 to push the lifting plate 31, so that the lifting plate 31 in the chip pressing mechanism 30 presses on the microfluidic chip, and the lifting plate 31 in the collection box support mechanism 40 presses on the droplet collection box;
further, the locking member 36 is driven by the hollow lifting button 34 to disengage from the hollow support rod 21, so that the hollow support rod 21 releases its restriction on the movement of the lifting plate 31, and the hollow lifting button 34 is driven by the second spring 35 to return to the original working position.
Specifically, please refer to fig. 5 and 6 again, the housing of the hollow support rod 21 is provided with two limiting holes 211 sequentially from top to bottom;
the locking component 36 comprises a sliding rail block 362 slidably connected with the inner wall of the lifting plate 31, a cylindrical pin 361 installed at one end of the sliding rail block 362 and inserted into the limiting hole, and a third spring 363 installed at the other end of the sliding rail block 362, wherein a support plate 364 is connected to one end of the third spring 363 away from the sliding rail block 362, and the support plate 364 is installed inside the lifting plate 31;
the locking member 36 further comprises a leg 365 mounted on the hollow knob 34 and extending to the lower surface of the inner end of the lifting plate 31, wherein the leg 365 is slidably connected to the sliding block 362;
a groove 311 is arranged on one side surface of the lifting plate 31 close to the fixed plate 51;
it should be noted that, in this embodiment, the support plate 364 provides support for the third spring 363, and the sliding rail block 362 stores energy through the third spring 363, so that the sliding rail block 362 drives the cylindrical pin 361 to be inserted into the limiting hole 211, and the movement of the sliding rail block 362 is limited by the limiting hole 211;
further, when the hollow lifting button 34 is pressed to be close to the fixing plate 51, the hollow lifting button 34 drives the supporting leg 365 to be close to the fixing plate 51, and the supporting leg 365 slides on the sliding rail of the sliding rail block 362, so as to push the sliding rail block 362 to be separated from the limit of the limiting hole 211;
further, the lifting plate 31 of the chip pressing mechanism 30 restricts the movement of the microfluidic chip by the groove 311, and the lifting plate 31 of the collection tank supporting mechanism 40 restricts the movement of the droplet collection tank by the groove 311.
Specifically, referring to fig. 7 and 8 again, rubber pressure pads 531 are mounted on the upper and lower surfaces of the supporting plate 53;
a second one-way valve 24 is mounted on the outer surface of the piston rod 22, an air outlet end of the second one-way valve 24 is connected with a vacuum breaking pipe 25, and an air outlet end of the vacuum breaking pipe 25 is communicated with the air suction pipe 541;
the two ends of the through hole 52 are provided with clamping grooves 521;
it should be noted that, in this embodiment, after the supporting plate 53 abuts against the microfluidic chip and the droplet-limiting collecting box, the supporting plate 53 reduces the gap between the supporting plate 53 and the microfluidic chip and the droplet-limiting collecting box through the rubber pressure pad 531;
further, when the piston rod 22 is pushed to exhaust, air inside the piston rod 22 enters the vacuum breaking pipe 25 through the second one-way valve 24, enters the air suction pipe 541 through the vacuum breaking pipe 25, and breaks the vacuum state of the air suction pipe 541;
further, the through hole 52 adapts to the shape of the microfluidic chip and the droplet collection box through the clamping groove 521;
further, the vacuum breaking tube 25 is not connected to the suction tube 541 but connected to a gas supply channel on the fixing plate 51, the gas supply channel is symmetrically arranged with the through hole 52 as a central axis, and a pushing column is slidably connected to the gas supply channel and pushes the pushing column through the air rushing into the gas supply channel, thereby extending into the through hole 52, clamping the droplet collecting box and the microfluidic chip, a pressure release valve is arranged on the fixing plate 51 and connected to the gas supply channel and the suction tube 541, so that after the pressure release valve is opened, the gas supply channel and the suction tube 541 can be quickly recovered.
The specific operation mode of the invention is as follows:
the hollow lifting button 34 drives the locking part 36 to be separated from the hollow supporting rod 21, so that the hollow supporting rod 21 releases the limit of the hollow supporting rod on the movement of the lifting plate 31, the lifting plate 31 is stored by the first spring 32 to push the lifting plate 31, so that the lifting plate 31 in the chip pressing mechanism 30 is pressed on the microfluidic chip, and the lifting plate 31 in the collecting box supporting mechanism 40 is pressed on the droplet collecting box, so that the droplet collecting box and the microfluidic chip are both pressed on the supporting plate 53;
the lifting rod 23 drives the piston rod 22 to perform air suction, so that the negative pressure adsorption head 542 communicated with the piston rod 22 performs air suction, negative pressure is formed between the droplet collection box and the microfluidic chip and the support plate 53, the droplet collection box and the microfluidic chip are adsorbed on the support plate 53, and the droplet collection box and the microfluidic chip are tightly connected with the support plate 53;
when the piston rod 22 is pushed to exhaust, air inside the piston rod 22 enters the inside of the vacuum breaking pipe 25 through the second check valve 24, enters the suction pipe 541 through the vacuum breaking pipe 25, and breaks the vacuum state of the suction pipe 541.
The invention is described above with reference to the accompanying drawings, it is obvious that the invention is not limited to the above-described embodiments, and it is within the scope of the invention to adopt such insubstantial modifications of the inventive method concept and solution, or to apply the inventive concept and solution directly to other applications without modification.
Claims (10)
1. A medical micro-fluidic chip droplet collecting device comprises a base (10), and is characterized in that a supporting frame (20) is mounted on the upper surface of the base (10), a chip pressing mechanism (30) is arranged at the top end of the supporting frame (20), a collecting box supporting mechanism (40) is arranged at the bottom end of the supporting frame (20), and a negative pressure fixing mechanism (50) is arranged between the chip pressing mechanism (30) and the collecting box supporting mechanism (40);
the supporting frame (20) comprises two hollow supporting rods (21) arranged on the upper surface of the base (10), piston rods (22) penetrating through the hollow supporting rods (21), and lifting rods (23) connected with the top ends of the two piston rods (22);
the negative pressure fixing mechanism (50) comprises a fixing plate (51) arranged on the shell of the hollow support rod (21) in a penetrating mode, a through hole (52) arranged on the shell of the fixing plate (51), a support plate (53) arranged on the inner wall of the hole body of the through hole (52), and negative pressure adsorption components (54) arranged on two sides of the support plate (53);
the negative pressure adsorption assembly (54) comprises an air suction pipe (541) arranged on the fixing plate (51) in a penetrating mode, one end of the air suction pipe (541) is arranged on the supporting plate (53) shell in a penetrating mode and is provided with two negative pressure adsorption heads (542), the other end of the air suction pipe (541) is provided with a first one-way valve (543), and the first one-way valve (543) is connected with an air outlet end of the piston rod (22).
2. The microfluidic chip droplet collecting device of claim 1, wherein the chip pressing mechanism (30) and the collecting box supporting mechanism (40) have the same structure, and the chip pressing mechanism (30) comprises a lifting plate (31) disposed on the two hollow supporting rods (21), a first spring (32) abutting against one end of the lifting plate (31) far away from the fixing plate (51) and sleeved outside the hollow supporting rod (21), and a supporting ring (33) abutting against one side surface of the first spring (32) far away from the fixing plate (51) and sleeved outside the hollow supporting rod (21).
3. The microfluidic chip droplet collecting device according to claim 2, wherein the chip pressing mechanism (30) further comprises a hollow lifting button (34) penetrating the housing of the lifting plate (31), a second spring (35) disposed on the lower surface of the hollow lifting button (34) extending to the inner end of the lifting plate (31), and a locking member (36) connected to the hollow lifting button (34) extending to the inner end of the lifting plate (31).
4. The medical microfluidic chip droplet collecting device according to claim 3, wherein the housing of the hollow support rod (21) is provided with two limiting holes (211) in sequence from top to bottom.
5. The medical microfluidic chip droplet collection device according to claim 4, wherein the locking component (36) comprises a sliding rail block (362) slidably connected to the inner wall of the lifting plate (31), a cylindrical pin (361) mounted at one end of the sliding rail block (362) and penetrating through the limiting hole, and a third spring (363) mounted at the other end of the sliding rail block (362), wherein a support plate (364) is connected to one end of the third spring (363) far away from the sliding rail block (362), and the support plate (364) is mounted inside the lifting plate (31).
6. The microfluidic chip droplet collecting device for medical use according to claim 5, wherein the locking member (36) further comprises a leg (365) mounted on the hollow lifting button (34) and extending to a lower surface of an inner end of the lifting plate (31), the leg (365) being slidably connected to the slide block (362).
7. The microfluidic chip droplet collecting device for medical use according to claim 6, wherein the lifting plate (31) has a groove (311) formed on a surface thereof near one side of the fixing plate (51).
8. The microfluidic chip droplet collecting device for medical use according to claim 1, wherein the supporting plate (53) is provided with rubber pressure pads (531) on both upper and lower surfaces thereof.
9. The medical microfluidic chip droplet collecting device according to claim 1, wherein a second one-way valve (24) is installed on an outer surface of the piston rod (22), an air outlet end of the second one-way valve (24) is connected with a vacuum breaking tube (25), and an air outlet end of the vacuum breaking tube (25) is communicated with the air suction tube (541).
10. The medical microfluidic chip droplet collecting device according to claim 1, wherein the through hole (52) is provided with a clamping groove (521) at both ends.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210691800.7A CN115138416A (en) | 2022-06-17 | 2022-06-17 | Medical micro-fluidic chip liquid drop collection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210691800.7A CN115138416A (en) | 2022-06-17 | 2022-06-17 | Medical micro-fluidic chip liquid drop collection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115138416A true CN115138416A (en) | 2022-10-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210691800.7A Pending CN115138416A (en) | 2022-06-17 | 2022-06-17 | Medical micro-fluidic chip liquid drop collection device |
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| CN (1) | CN115138416A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040025602A1 (en) * | 2002-08-08 | 2004-02-12 | Norton Pierce O. | Sort block and liquid collection device for sorting flow cytometer |
| CN105396632A (en) * | 2015-12-14 | 2016-03-16 | 苏州汶颢芯片科技有限公司 | Liquid drop collection device based on micro-fluidic chip |
| CN206392093U (en) * | 2017-01-14 | 2017-08-11 | 辽宁工业大学 | A kind of droplet collection device based on micro-fluidic chip |
| CN209271489U (en) * | 2018-09-19 | 2019-08-20 | 天津力芯伟业科技有限公司 | A kind of droplet collection device of chip |
| CN213557099U (en) * | 2020-10-12 | 2021-06-29 | 联暻半导体(山东)有限公司 | Liquid drop collection device based on high-reliability chip |
-
2022
- 2022-06-17 CN CN202210691800.7A patent/CN115138416A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040025602A1 (en) * | 2002-08-08 | 2004-02-12 | Norton Pierce O. | Sort block and liquid collection device for sorting flow cytometer |
| CN105396632A (en) * | 2015-12-14 | 2016-03-16 | 苏州汶颢芯片科技有限公司 | Liquid drop collection device based on micro-fluidic chip |
| CN206392093U (en) * | 2017-01-14 | 2017-08-11 | 辽宁工业大学 | A kind of droplet collection device based on micro-fluidic chip |
| CN209271489U (en) * | 2018-09-19 | 2019-08-20 | 天津力芯伟业科技有限公司 | A kind of droplet collection device of chip |
| CN213557099U (en) * | 2020-10-12 | 2021-06-29 | 联暻半导体(山东)有限公司 | Liquid drop collection device based on high-reliability chip |
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