CN115138274B - Shaking mixing system for preparation of tetravalent influenza virus subunit vaccine - Google Patents
Shaking mixing system for preparation of tetravalent influenza virus subunit vaccine Download PDFInfo
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- CN115138274B CN115138274B CN202210714823.5A CN202210714823A CN115138274B CN 115138274 B CN115138274 B CN 115138274B CN 202210714823 A CN202210714823 A CN 202210714823A CN 115138274 B CN115138274 B CN 115138274B
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- 238000002156 mixing Methods 0.000 title claims abstract description 28
- 229940031626 subunit vaccine Drugs 0.000 title claims abstract description 16
- 241000712461 unidentified influenza virus Species 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title abstract description 8
- 241000700605 Viruses Species 0.000 claims abstract description 93
- 230000003014 reinforcing effect Effects 0.000 claims abstract description 14
- 238000013016 damping Methods 0.000 claims abstract description 13
- 230000001360 synchronised effect Effects 0.000 claims abstract description 4
- 230000007306 turnover Effects 0.000 claims description 58
- 230000000694 effects Effects 0.000 claims description 11
- 238000009434 installation Methods 0.000 claims description 9
- 238000003466 welding Methods 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims 1
- 238000005728 strengthening Methods 0.000 claims 1
- 230000002779 inactivation Effects 0.000 abstract description 15
- 238000000034 method Methods 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 9
- 238000005253 cladding Methods 0.000 description 11
- 229960005486 vaccine Drugs 0.000 description 10
- 230000000415 inactivating effect Effects 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000035939 shock Effects 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000002146 bilateral effect Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 229960003971 influenza vaccine Drugs 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a tetravalent influenza virus subunit vaccine preparation shaking mixing system, which comprises a shaking base, wherein a vertical support is fixedly arranged on the shaking base, a slope groove is formed in the shaking base, a reinforcing rib is fixedly arranged on the vertical support, a laminated plate is fixedly arranged between the vertical support and the reinforcing rib, a spring rod is fixedly arranged on the vertical support, a hanging piece is slidably arranged on the spring rod, the hanging piece is fixedly connected to a movable plate, a multistage pushing structure is arranged on the movable plate, a limiting seat is fixedly arranged on the laminated plate, a sliding rod is slidably arranged in the limiting seat, a damping top plate and a triangular block are fixedly connected to the sliding rod, and a jacking structure with a double-side synchronous control function is arranged on the shaking base; the shaking mixing system is used for accelerating the virus inactivation process, can shake the virus tank, and can gradually reduce the amplitude from top to bottom, so that the excessive virus inactivation is not easy to cause.
Description
Technical Field
The invention relates to the technical field of vaccine preparation, in particular to a shaking mixing system for tetravalent influenza virus subunit vaccine preparation.
Background
In the growth process of human, multiple vaccinations are often carried out, and human immunity is formed through different vaccines, so that external virus invasion is dealt with, the probability of illness is reduced, or the serious disease rate is reduced. Influenza vaccine is developed mainly aiming at influenza, and is one of common vaccines for children. The tetravalent influenza virus subunit vaccine is a component vaccine containing a new antigen form, has the characteristics of high purity, low side effect of inoculation and good safety, and is suitable for children and the elderly. Clinical data shows that the vaccine is safe and effective, and can provide wider and sufficient protection for society in the aspect of preventing seasonal influenza virus.
The tetravalent influenza subunit vaccine is an inactivated vaccine, and in the production and preparation process, the virus is cultured first and then inactivated, so that the safe and reliable influenza vaccine is obtained. At present, virus inactivation usually adopts two modes of an inactivating agent or high-temperature treatment, and after the inactivating agent is added into a virus reagent, the inactivating agent and the virus reagent are required to be ensured to be in uniform contact with each other, so that a good inactivating effect is achieved. However, the mixing systems used in the prior art are all single stirring or shaking mechanisms, so that the degree of mixing is difficult to control, and excessive reaction is easy to occur, so that vaccine failure is caused.
Disclosure of Invention
The invention aims to provide a shaking mixing system for preparing tetravalent influenza virus subunit vaccine, so as to achieve the purposes of gradually decelerating and shaking and limiting the virus inactivation degree, and solve the problems in the prior art.
In order to achieve the above purpose, the present invention provides the following technical solutions: the shaking mixing system for tetravalent influenza virus subunit vaccine preparation comprises a shaking base, wherein a vertical support is fixedly arranged on the shaking base, a slope groove is formed in the shaking base, a plurality of reinforcing ribs are arranged on the vertical support from top to bottom in a welding mode, a laminated plate is fixedly arranged on the reinforcing ribs, the reinforcing ribs and the laminated plate divide the vertical support into a plurality of working spaces, a through groove is formed in the middle of the laminated plate, a turnover support plate is rotatably arranged in the through groove, a limiting strip is fixedly arranged on the turnover support plate, a virus tank is placed on the turnover support plate, a backboard is fixedly arranged on the vertical support, a limiting spring is fixedly connected onto the backboard, an installation seat is fixedly connected onto the limiting spring, a limiting piece is fixedly arranged on the installation seat, a spring rod is fixedly arranged on the vertical support, the suspension member is slidingly arranged on the spring rod, the suspension member is fixedly connected on the movable plate, the connecting rod and the driving disc form a crank sliding block structure, the connecting rod is connected on the back of the movable plate through a rotating shaft, the movable plate is driven to reciprocate through the rotation of the driving disc, a multi-stage pushing structure is arranged on the movable plate, the multi-stage pushing structure is provided with a push plate with a limit position gradually shrinking from top to bottom along the direction of the vertical support, the effect of hierarchically pushing virus tanks to move different distances is realized, a limiting seat is fixedly arranged on the laminated plate, a sliding rod is slidingly arranged in the limiting seat, a damping top plate and a triangular block are fixedly connected on the sliding rod, a reset spring is fixedly connected on the triangular block, a jacking structure with a double-side synchronous control function is arranged on the rocking base, realize the layer-by-layer opening and closing of the overturning support plate.
Preferably, the bottom of the shaking base is provided with support legs, the vertical support is composed of four vertical rod pieces, a square channel is formed above the shaking base, the slope groove is formed in the bottom of the square channel, the reinforcing ribs are arranged at the bottom of the layered plates, the layered plates are arranged at least four along the vertical support in an equidistant mode, the two turnover support plates are arranged on each layered plate in a mirror image mode, the turnover support plates are installed through hinges, and the limiting strips are installed on the upper surface of the turnover support plates.
Preferably, the backplate is installed between two members of perpendicular support, and limit spring installs in the backplate one side towards the layering board, the locating part passes through the screw and installs on the mount pad, and the locating part is provided with the arc surface of taking the bed course, and the vertical arrangement setting of locating part, and its quantity keeps unanimous with the layering board.
Preferably, the spring rod is vertically connected to the two rod pieces of the vertical support, the hanging piece is arranged on the spring rod in a limiting sliding mode, the hanging piece is arranged on the back face of the movable plate, the connecting rod and the driving disc form a crank sliding block structure, and the driving disc is driven by the speed reducing motor.
Preferably, the multistage pushing structure comprises a threaded rod arranged along the movable plate, a balance spring is sleeved on the threaded rod, one end of the balance spring is connected to the cladding plate, the other end of the balance spring is connected to the movable plate, the cladding plate is hung on the threaded rod through a through hole, an adjusting nut is connected to the threaded rod in a threaded manner, the adjusting nut presses the pushing plate on the balance spring, and a buffer bar is fixedly installed on the pushing plate.
Preferably, the threaded rods are arranged in pairs, the push plates are connected in a balanced manner through the two threaded rods, the push plates are located between two upper and lower adjacent layered plates, the push plates are connected between two external plates, two ends of each balance spring are respectively connected to the movable plate and the push plates, and the buffer strips are adhered to the surfaces of the push plates.
Preferably, the spacing seat is installed in the bottom of layering board, and is provided with the spout on the spacing seat, the slide bar runs through the spout and installs, and shock attenuation roof and triangle piece are connected respectively at the both ends of slide bar, the shock attenuation roof top is in the bottom of upset extension board, carries out the support of upset extension board, and reset spring's both ends are connected respectively on triangle piece and layering board.
Preferably, the jacking structure comprises a screw rod rotatably mounted on the shaking base and a guide rod fixedly mounted on the shaking base, a nut seat is mounted on the screw rod and the guide rod, a turnover support is mounted on the nut seat in a unidirectional rotation mode, a push rod is fixedly mounted on the turnover support, a first bevel gear is fixedly mounted on the screw rod, a second bevel gear is mounted on the first bevel gear in a meshed mode, the second bevel gear is fixedly mounted on a linkage shaft, and the linkage shaft is fixedly connected to a driving motor.
Preferably, the guide bar sets up in the both sides of lead screw, guide bar and lead screw are provided with two sets of in the bilateral symmetry of layering board, and nut seat threaded connection is on the lead screw to connect on the guide bar through the slide hole, turn over the support and install through the pivot, and turn over the support below and be provided with the dog, the push rod is installed and is turning over the tip of support, first bevel gear is installed in the bottom of lead screw, and the second bevel gear is provided with two on the universal driving shaft, driving motor fixed mounting is on rocking the base.
Compared with the prior art, the invention has the beneficial effects that:
1. the shaking mixing system is used for accelerating the virus inactivation process, a vertical channel is formed by the vertical support, a plurality of layered plates are equidistantly arranged in the channel, the virus tank with the virus and the inactivating agent can be placed on the vertical channel, the virus tank can be shaken on the vertical channel to further accelerate the mixing of the reagent and the virus, and particularly, the shaking amplitude of the virus tank on each layered plate is different and can be gradually reduced from top to bottom, so that each virus tank firstly shakes at the maximum amplitude and then falls down step by step, the shaking amplitude is reduced, finally slides out of the inclined groove, limited shaking mixing work is completed, the excessive inactivation of the virus is not easy to be caused, and the vaccine effect is ensured.
2. According to the invention, the virus tank can be ensured to shake within a certain range, one side of the vertical support is provided with the limiting structure, the other side of the vertical support is provided with the driving mechanism, the movable plate can rapidly reciprocate and linearly, one side of the movable plate, facing the virus tank, is provided with the multistage pushing structure, and the pushing effects with different amplitudes can be generated for the virus tanks on different laminated plates when the moving distances of the movable plate are the same, so that the shaking amplitude of the virus tank on the upper layer is always larger than that of the virus tank on the lower layer, the shaking amplitude of each layer is reduced layer by layer, and the shaking amplitude difference of each layer can be further adjusted through the adjusting nut.
3. According to the invention, the turnover support plate is used for supporting the virus tank, the turnover support plate is arranged to be in an openable structure, when the position is exchanged, the triangular block is pushed outwards from the lowest layered plate through the jacking structure, the damping top plate is pulled to move outwards through the sliding rod, and the virus tank is separated from the lower part of the turnover support plate, so that the virus tank on the turnover support plate falls off, the turnover support plate is opened layer by layer, the virus tank also falls down layer by layer, and the situation that a vacancy is always reserved below is ensured.
Drawings
Fig. 1 is a first schematic view of the overall structure of the present invention.
Fig. 2 is a second schematic view of the overall structure of the present invention.
Fig. 3 is a schematic view of a base structure of the present invention.
Fig. 4 is a schematic view of a multi-stage rocking structure of the present invention.
Fig. 5 is a schematic view of a single stage rocking structure of the present invention.
Fig. 6 is a schematic view of a pushing structure of the present invention.
Fig. 7 is a schematic view of a support structure according to the present invention.
Fig. 8 is a schematic view of the distance adjusting structure of the present invention.
Fig. 9 is a schematic view of an opening structure of the present invention.
Fig. 10 is an enlarged schematic view of area a in fig. 8.
In the figure: the device comprises a shaking base 1, a vertical support 2, a slope groove 3, a reinforcing rib 4, a layering plate 5, a turnover support plate 6, a limit bar 7, a back plate 8, a limit spring 9, an installation seat 10, a limit piece 11, a spring rod 12, a hanging piece 13, a movable plate 14, a connecting rod 15, a driving disc 16, a threaded rod 17, a balance spring 18, a hanging plate 19, an adjusting nut 20, a push plate 21, a buffer bar 22, a limit seat 23, a slide bar 24, a shock absorption top plate 25, a triangular block 26, a reset spring 27, a screw rod 28, a guide rod 29, a nut seat 30, a turnover support 31, a push rod 32, a first bevel gear 33, a second bevel gear 34, a linkage shaft 35 and a driving motor 36.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and detailed description, wherein it is to be understood that, under the precondition of no conflict, new embodiments can be formed by any combination of the embodiments or technical features described below, and it should be understood that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1 to 10, the present invention provides a technical solution: a shaking mixing system for tetravalent influenza virus subunit vaccine preparation comprises a shaking base 1, a vertical support 2 is fixedly arranged on the shaking base 1, a slope groove 3 is arranged on the shaking base 1, a plurality of reinforcing ribs 4 are arranged on the vertical support 2 from top to bottom in a welding mode, a laminated plate 5 is fixedly arranged on the reinforcing ribs 4, the reinforcing ribs 4 and the laminated plate 5 divide the vertical support 2 into a plurality of working spaces, a through groove is arranged in the middle of the laminated plate 5, a turnover support plate 6 is rotatably arranged in the through groove, a limit strip 7 is fixedly arranged on the turnover support plate 6, a virus tank is placed on the turnover support plate 6, a backboard 8 is fixedly arranged on the vertical support 2, a limit spring 9 is fixedly connected on the backboard 8, a mounting seat 10 is fixedly connected on the limit spring 9, a limit piece 11 is fixedly arranged on the mounting seat 10, a spring rod 12 is fixedly arranged on the vertical support 2, the suspension member 13 is slidingly arranged on the spring rod 12, the suspension member 13 is fixedly connected on the movable plate 14, the connecting rod 15 and the driving disc 16 form a crank sliding block structure, the connecting rod 15 is connected on the back of the movable plate 14 through a rotating shaft, the movable plate 14 is driven to reciprocate through the rotation of the driving disc 16, a multi-stage pushing structure is arranged on the movable plate 14, the multi-stage pushing structure is provided with a push plate 21 with gradually contracted limit positions from top to bottom along the direction of the vertical support 2, the effect of hierarchically pushing virus cans to move different distances is realized, a limiting seat 23 is fixedly arranged on the laminated plate 5, a sliding rod 24 is slidingly arranged in the limiting seat 23, a damping top plate 25 and a triangular block 26 are fixedly connected on the sliding rod 24, a reset spring 27 is fixedly connected on the triangular block 26, a top pressing structure with double-side synchronous control function is arranged on the shaking base 1, the overturning support plate 6 is opened and closed layer by pushing the triangular blocks 26 from bottom to top.
The bottom of the shaking base 1 is provided with supporting feet, the vertical support 2 is composed of four vertical rods, a square channel is formed above the shaking base 1, the slope groove 3 is formed in the bottom of the square channel, the reinforcing ribs 4 are arranged at the bottom of the layered plates 5, the layered plates 5 are arranged at least four along the vertical support 2 in an equidistant mode, the overturning support plates 6 are arranged on each layered plate 5 in a mirrored mode, the overturning support plates 6 are installed through hinges, and the limiting bars 7 are installed on the upper surfaces of the overturning support plates 6.
The shaking mixing system is used for accelerating the virus inactivation process, takes a shaking base 1 as a basic structure, forms a vertical channel through a vertical bracket 2, is provided with a plurality of layering plates 5 at equal intervals in the channel, is provided with a turnover support plate 6 at the center of each layering plate 5, can place virus cans with viruses and inactivating agents when the two turnover support plates 6 are closed, can move along the direction of a limit strip 7, and shake reagents in the virus cans to accelerate the virus inactivation, and particularly, the shaking amplitude of the virus cans on each layering plate is different, can gradually reduce the amplitude from top to bottom, so that each virus can firstly shake at the maximum amplitude and then gradually falls down, the shaking amplitude is reduced, and finally slides out of a slope groove 3, thereby completing limited shaking mixing work, ensuring the effect of vaccines, and avoiding excessive virus inactivation; in the traditional shaking system, a single virus tank is always continuously shaken, the degree of inactivation is controlled by adjusting the shaking speed, the efficiency is low, the material replacement and the cleaning are both required to be stopped, the problems of excessive inactivation and insufficient vaccine activity are more easily caused, the shaking mixing system is more similar to a production line, the virus tank is subjected to a mixing process from top to bottom, the shaking system does not need to be stopped, the virus tank has sufficient time for material replacement and cleaning, and the virus inactivation efficiency is improved.
The backplate 8 is installed between two members of erectting support 2, and spacing spring 9 installs in backplate 8 towards the one side of layering board 5, and locating part 11 passes through the screw and installs on mount pad 10, and locating part 11 is provided with the arc surface of taking the bed course, and the vertical arrangement setting of locating part 11, and its quantity keeps unanimous with layering board 5.
The virus tank is placed on the layering plate 5, and in order to achieve the effect of shaking and mixing, driving and limiting of the virus tank are needed, and the virus tank is guaranteed to shake within a certain range, so that the back plate 8 is installed on one side of the vertical support 2, the limiting piece 11 is installed on the vertical support through the limiting spring 9 and the installation seat 10, and the vertical support can be propped against the virus tank to limit the virus tank.
The spring rod 12 is vertically connected to two rod pieces of the vertical support 2, the hanging piece 13 is mounted on the spring rod 12 in a limiting sliding mode, the hanging piece 13 is mounted on the back face of the movable plate 14, the connecting rod 15 and the driving disc 16 form a crank sliding block structure, and the driving disc 16 is driven by a gear motor.
On the other side of the vertical support 2, a driving mechanism is arranged on the opposite side of the back plate 8, a crank block structure is formed by a movable plate 14, a connecting rod 15 and a driving disc 16, and when the driving disc 16 rotates, the movable plate 14 can be driven to rapidly reciprocate in a linear motion along the direction of the spring rod 12.
The multistage pushing structure comprises a threaded rod 17 arranged along the movable plate 14, a balance spring 18 is sleeved on the threaded rod 17, one end of the balance spring 18 is connected to the cladding plate 19, the other end of the balance spring is connected to the movable plate 14, the cladding plate 19 is hung on the threaded rod 17 through a through hole, an adjusting nut 20 is connected to the threaded rod 17 in a threaded manner, the adjusting nut 20 presses a push plate 21 on the balance spring 18, and a buffer bar 22 is fixedly installed on the push plate 21.
The movable plate 14 is installed on one surface facing the virus tank in a multistage pushing structure, so that different pushing effects can be generated for the virus tanks on different layering plates 5 when the moving distances of the movable plate 14 are the same, and the shaking amplitude of the virus tank on the upper layer is always larger than that of the virus tank on the lower layer;
the threaded rods 17 are arranged in pairs, the push plates 21 are connected in a balanced mode through the two threaded rods 17, the push plates 21 are located between the two layered plates 5 which are adjacent up and down, the push plates 21 are connected between the two cladding plates 19, two ends of the balance springs 18 are respectively connected to the movable plates 14 and the push plates 21, and the buffer strips 22 are adhered to the surfaces of the push plates 21.
The multistage pushing structure mainly comprises a plurality of pairs of threaded rods 17 for basic installation, movable installation of the cladding 19 is carried out on the multistage pushing structure, the push plates 21 are installed on the cladding 19, balance is achieved with the balance springs 18 through rotation of the adjusting nuts 20, the limiting positions of the cladding 19 and the push plates 21 inwards are adjusted, the push plates 21 of each layer are adjusted to be inwards contracted from top to bottom, when the push plates 21 of the upper layer are pushed inwards by the movable plates 14, the push plates 21 of the upper layer are contacted with virus cans to push the virus cans for a larger distance, so that the shaking amplitude of the virus cans of the upper layer is larger, the shaking amplitude of each layer is reduced, and the shaking amplitude difference of each layer can be further adjusted through the adjusting nuts 20.
The limiting seat 23 is arranged at the bottom of the laminated plate 5, a sliding groove is formed in the limiting seat 23, the sliding rod 24 penetrates through the sliding groove to be installed, the damping top plate 25 and the triangular block 26 are respectively connected to the two ends of the sliding rod 24, the damping top plate 25 is propped against the bottom of the overturning supporting plate 6 to support the overturning supporting plate 6, and the two ends of the reset spring 27 are respectively connected to the triangular block 26 and the laminated plate 5.
The virus tank is supported on the laminated plate 5 through the turnover support plate 6, and the virus tank is required to be gradually dropped onto the laminated plate 6 at the lower layer, so that the virus tank is pushed by different amplitudes and gradually subjected to deceleration shaking, the turnover support plate 6 is arranged to be in an openable structure, when the position is exchanged, the triangular block 26 is pushed outwards through the jacking structure from the lowest laminated plate 5, the shock absorption top plate 25 is pulled to move outwards through the sliding rod 24, and is separated from the lower part of the turnover support plate 6, so that the virus tank on the turnover support plate 6 falls, the turnover support plate 6 is opened layer by layer, and the virus tank also falls down layer by layer, so that the situation that a vacancy is always reserved below is ensured; the virus jar adopts the plastic tank of bottom thickening, has certain deformation shock-absorbing capacity to turn over and be provided with the cushion on the extension board 6, be used for supporting to turn over the shock attenuation roof 25 of extension board 6 and also adopt shock-absorbing structure, can effectually guarantee that the virus jar is mild falls on turning over extension board 6, prevent that the virus jar is damaged.
The jacking structure comprises a screw rod 28 rotatably mounted on a shaking base 1 and a guide rod 29 fixedly mounted on the shaking base 1, wherein a nut seat 30 is mounted on the screw rod 28 and the guide rod 29, a turnover support 31 is mounted on the nut seat 30 in a unidirectional rotation manner, a push rod 32 is fixedly mounted on the turnover support 31, a first bevel gear 33 is fixedly mounted on the screw rod 28, a second bevel gear 34 is mounted on the first bevel gear 33 in a meshed manner, the second bevel gear 34 is fixedly mounted on a linkage shaft 35, and the linkage shaft 35 is fixedly connected to a driving motor 36.
The jacking structure is a reciprocating structure, when the pneumatic device works, triangular blocks 26 and even damping top plates 25 are pushed from bottom to top, so that the overturning support plates 6 can finish an opening and closing process layer by layer, the position of a virus tank is helped to be switched, and when the pneumatic device resets from top to bottom, the triangular blocks 26 are not affected.
The guide bar 29 sets up in the both sides of lead screw 28, and guide bar 29 and lead screw 28 are provided with two sets of in the bilateral symmetry of layering board 5, and nut seat 30 threaded connection is on lead screw 28, and connect on guide bar 29 through the slide hole, turn over a support 31 and install through the pivot, and turn over a support 31 below and be provided with the dog, push rod 32 installs in the tip of turning over a support 31, first bevel gear 33 installs in the bottom of lead screw 28, and second bevel gear 33 is provided with two on universal driving shaft 35, driving motor 36 fixed mounting is on rocking base 1.
Specifically, the driving motor 36 drives the linkage shaft 35 to rotate, and drives the screw rod 28 to rotate through the transmission of the second bevel gear 33 and the first bevel gear 32, the nut seat 30 on the screw rod 28 moves from bottom to top, the triangular block 26 is located on a moving path of the nut seat 30, the turnover support 31 on the nut seat 30 is limited by the stop block, the turnover support 31 on the nut seat 30 cannot rotate when pushing the triangular block 26 from below, the turnover support 31 on the nut seat 30 moves to a position contacting with the bottom inclined surface of the triangular block 26, the turnover support 31 continuously moves upwards, the push rod 32 on the turnover support 32 generates thrust along the bottom inclined surface direction of the triangular block 26, the triangular block 26 has a trend of moving upwards obliquely along the stressed direction, and meanwhile the triangular block 26 is limited by the slide rod 24 in the vertical direction, so that the triangular block 26 can move outwards in the horizontal direction, the push rod 32 can push the triangular block 26, and then drive the shock absorption top plate 25 to move from below the support plate 6, and the two turnover support plates 6 can be simultaneously driven to open, so that viruses on the turnover support 6 can be reset when the turnover support 36 is driven, and the turnover support 32 can be prevented from being influenced when the turnover support 6 is driven; the nut seat 30 and the push rods 32 on the nut seat 30 are pushed by all the triangular blocks 26 from bottom to top in sequence, so that the folding support plates 6 are opened one by one in sequence, the virus tank drops quickly, after the push rods 32 are separated from the triangular blocks 26, the damping top plate 25 can be reset under the action of the reset springs 27, the folding support plates 6 can be reset quickly, the nut seat 30 can move upwards continuously to open the folding support plates 6 of the upper layer, and as the triangular blocks 26 of each layer of folding support plates 6 are controlled to have a certain distance from each other, the folding support plates 6 can be reset for a long time, so that the situation that the folding support plates 6 of the upper layer are opened and the folding support plates 6 of the lower layer are not reset yet is avoided; only after the layer change work of the virus tank in the whole shaking system is completed, the driving motor drives the screw rod 28 to rotate reversely, so that the nut seat 30 moves downwards from the uppermost direction to reset.
The invention is used when in use: firstly, the shaking mixing system of the invention is used for accelerating the virus inactivation process, takes a shaking base 1 as a basic structure, forms a vertical channel through a vertical bracket 2, and is also provided with a plurality of layering plates 5 equidistantly arranged in the channel, the center of each layering plate 5 is provided with a turnover supporting plate 6, when two turnover supporting plates 6 are closed, the placement of virus cans with viruses and inactivating agents can be carried out, and the virus cans can move along the direction of a limit bar 7, so that reagents in the shaking mixing system accelerate the virus inactivation, particularly, the shaking amplitude of the virus cans on each layering plate is different, the shaking amplitude can be gradually reduced from top to bottom, so that each virus can firstly shakes at the maximum amplitude and then gradually falls down, the shaking amplitude is reduced, and finally slides out of a slope groove 3, the limited shaking mixing work is completed, excessive inactivation of viruses is not easy to cause, the effect of vaccine is ensured, a virus tank is placed on the layering plate 5, driving and limiting of the virus tank are needed to be carried out, and the virus tank is ensured to shake within a certain range, so that one side of the vertical support 2 is provided with the back plate 8, the upper side of the vertical support 2 is provided with the limiting piece 11 through the limiting spring 9 and the mounting seat 10, the upper side of the vertical support 2 can be propped against the virus tank to limit the virus tank, the opposite side of the vertical support 2 is provided with a driving mechanism, a crank slide block structure is formed by the movable plate 14, the connecting rod 15 and the driving disc 16, when the driving disc 16 rotates, the movable plate 14 can be driven to carry out quick reciprocating linear motion along the direction of the spring rod 12, one side of the movable plate 14, which faces the virus tank, is provided with the multistage pushing structure, the multi-stage pushing structure mainly comprises a plurality of pairs of threaded rods 17 for basic installation, on which the movable installation of the cladding 19 is carried out, and a push plate 21 is installed on the cladding 19, and the balance spring 18 is balanced by the rotation of an adjusting nut 20, so that the inward limit positions of the cladding 19 and the push plate 21 are adjusted, the push plate 21 of each layer is adjusted to be retracted inwards from top to bottom, the push plate 21 of the upper layer is pushed by contacting with the virus tank when pushing in the movable plate 14, and pushes the virus tank of the upper layer for a larger distance, thereby the shaking amplitude of the virus tank of the upper layer is larger, and the layer by layer is reduced, the shaking amplitude difference of each layer can be further regulated through the regulating nut 20, the virus tank is supported on the laminated plate 5 through the overturning support plate 6, the virus tank is required to be ensured to gradually fall onto the laminated plate 6 at the lower layer and to be pushed by different amplitudes, and the speed-reducing shaking is gradually carried out, so the overturning support plate 6 is arranged into an openable structure, when the position is exchanged, the triangular block 26 is pushed outwards from the lowest laminated plate 5 through the jacking structure, the damping top plate 25 is pulled to move outwards through the sliding rod 24, the virus tank on the overturning support plate 6 is separated from the lower part of the overturning support plate 6, the virus tank is further enabled to fall down layer by layer, the empty space is ensured to be always arranged below, the jacking structure is a reciprocating structure, the triangular block 26 is pushed from bottom to top even the damping top plate 25 in the working process, the turnover support plate 6 can complete an opening and closing process layer by layer, the position of the virus tank is helped, when the virus tank is reset from top to bottom, the triangle block 26 is not affected, specifically, the driving motor 36 drives the linkage shaft 35 to rotate, the screw rod 28 is driven to rotate through the transmission of the second bevel gear 33 and the first bevel gear 32, the nut seat 30 on the screw rod 28 moves from bottom to top, the turnover support 31 on the nut seat 30 is limited by the stop block, the triangle block 26 is not rotated when being pushed from below, the push rod 32 can push the triangle block 26, and as the two nut seats 30 are also arranged, the two turnover support plates 6 can be simultaneously driven to be opened, so that the virus tank on the virus tank falls down, otherwise, when the driving motor 36 drives the nut seat 30 to reset, the turnover support 31 can be turned over, and the influence of the push rod 32 on the turnover support plate 6 is avoided.
The above embodiments are only preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, but various modifications can be made by those skilled in the art without inventive effort from the above concepts, and all modifications are within the scope of the present invention.
Claims (7)
1. A shaking mixing system for preparing tetravalent influenza virus subunit vaccine, comprising a shaking base (1), and is characterized in that: the shaking base (1) is fixedly provided with a vertical support (2), the shaking base (1) is provided with an inclined groove (3), a plurality of reinforcing ribs (4) are arranged on the vertical support (2) from top to bottom in a welding mode, a laminated plate (5) is fixedly arranged on the reinforcing ribs (4), the reinforcing ribs (4) and the laminated plate (5) divide the vertical support (2) into a plurality of working spaces, the middle part of the laminated plate (5) is provided with a through groove, the through groove is rotationally provided with a turnover support plate (6), the turnover support plate (6) is fixedly provided with a limiting strip (7), a virus tank is placed on the turnover support plate (6), the vertical support (2) is fixedly provided with a back plate (8), the back plate (8) is fixedly connected with a limit spring (9), the limit spring (9) is fixedly connected with a mounting seat (10), the mounting seat (10) is fixedly provided with a limit piece (11), the vertical support (2) is fixedly provided with a spring rod (12), the spring rod (12) is slidably provided with a hanging piece (13), the hanging piece (13) is fixedly connected with a movable plate (14), the movable plate (14), a connecting rod (15) and a driving disc (16) form a crank slide block structure, the connecting rod (15) is connected to the back of the movable plate (14) through a rotating shaft, the movable plate (14) is driven to reciprocate through rotation of the driving disc (16), a multistage pushing structure is arranged on the movable plate (14), the multistage pushing structure is gradually contracted along the direction of the vertical support (2) from top to bottom, a push plate (21) is arranged at the limit position, the effect of pushing virus cans to move different distances in a layering mode is achieved, a limiting seat (23) is fixedly arranged on the layering plate (5), a sliding rod (24) is slidably arranged in the limiting seat (23), a damping top plate (25) and a triangular block (26) are fixedly connected to the sliding rod (24), a reset spring (27) is fixedly connected to the triangular block (26), a jacking structure with a double-side synchronous control function is arranged on the shaking base (1), and layer-by-layer opening and closing of the overturning support plate (6) are achieved through pushing the triangular block (26) from bottom to top;
the multistage pushing structure comprises threaded rods (17) which are arranged along the movable plates (14), the threaded rods (17) are sleeved with balance springs (18), one ends of the balance springs (18) are connected to the outer hanging plates (19), the other ends of the balance springs are connected to the movable plates (14), the outer hanging plates (19) are hung on the threaded rods (17) through holes, adjusting nuts (20) are connected to the threaded rods (17) in a threaded mode, the adjusting nuts (20) press the pushing plates (21) on the balance springs (18), buffer strips (22) are fixedly mounted on the pushing plates (21), the threaded rods (17) are arranged in pairs, the two threaded rods (17) are connected in a balanced mode, the pushing plates (21) are located between the upper layered plates (5) and the lower layered plates (5), the pushing plates (21) are connected between the two outer hanging plates (19), the two ends of the balance springs (18) are connected to the movable plates (14) and the pushing plates (21) respectively, and the buffer strips (22) are adhered to the surfaces of the pushing plates (21).
2. The shake mixing system for preparing a tetravalent influenza virus subunit vaccine of claim 1, wherein: the utility model discloses a support structure for a floor, including base (1) and inclined groove, the base (1) bottom is provided with the stabilizer blade, and erects support (2) and comprises four vertical member bars, constitutes square passageway in base (1) top is rocked, and inclined groove (3) set up in the bottom of square passageway, strengthening rib (4) are installed in the bottom of layering board (5), and layering board (5) are arranged along erectting support (2) equidistance and are provided with four at least, upset extension board (6) mirror image is provided with two on every layering board (5), and upset extension board (6) pass through hinge mount, spacing (7) are installed at the upper surface of upset extension board (6).
3. The shake mixing system for preparing a tetravalent influenza virus subunit vaccine of claim 1, wherein: the back plate (8) is installed between two rod pieces of the vertical support (2), the limiting springs (9) are installed on one face, facing the layering plate (5), of the back plate (8), the limiting pieces (11) are installed on the installation base (10) through screws, the limiting pieces (11) are provided with arc-shaped surfaces with cushion layers, the limiting pieces (11) are vertically arranged, and the number of the limiting pieces is consistent with that of the layering plate (5).
4. The shake mixing system for preparing a tetravalent influenza virus subunit vaccine of claim 1, wherein: the spring rod (12) is vertically connected to two rod pieces of the vertical support (2), the hanging piece (13) is mounted on the spring rod (12) in a limiting sliding mode, the hanging piece (13) is mounted on the back face of the movable plate (14), the connecting rod (15) and the driving disc (16) form a crank sliding block structure, and the driving disc (16) is driven by a gear motor.
5. The shake mixing system for preparing a tetravalent influenza virus subunit vaccine of claim 1, wherein: the limiting seat (23) is arranged at the bottom of the laminated plate (5), a sliding groove is formed in the limiting seat (23), the sliding rod (24) penetrates through the sliding groove to be installed, a damping top plate (25) and a triangular block (26) are respectively connected to two ends of the sliding rod (24), the damping top plate (25) is propped against the bottom of the overturning support plate (6) to support the overturning support plate (6), and two ends of a reset spring (27) are respectively connected to the triangular block (26) and the laminated plate (5).
6. The shake mixing system for preparing a tetravalent influenza virus subunit vaccine of claim 1, wherein: the jacking structure comprises a screw rod (28) rotatably mounted on a shaking base (1) and a guide rod (29) fixedly mounted on the shaking base (1), wherein a nut seat (30) is mounted on the screw rod (28) and the guide rod (29), a turnover support (31) is mounted on the nut seat (30) in a unidirectional rotation mode, a push rod (32) is fixedly mounted on the turnover support (31), a first bevel gear (33) is fixedly mounted on the screw rod (28), a second bevel gear (34) is mounted on the first bevel gear (33) in a meshed mode, the second bevel gear (34) is fixedly mounted on a linkage shaft (35), and the linkage shaft (35) is fixedly connected to a driving motor (36).
7. The shake mixing system for preparing a tetravalent influenza virus subunit vaccine of claim 6, wherein: the guide rod (29) is arranged on two sides of the screw rod (28), the guide rod (29) and the screw rod (28) are symmetrically arranged on two sides of the layering plate (5) in two groups, the nut seat (30) is connected to the screw rod (28) through a sliding hole and is connected to the guide rod (29), the turnover support (31) is installed through a rotating shaft, a stop block is arranged below the turnover support (31), the push rod (32) is installed at the end part of the turnover support (31), the first bevel gear (33) is installed at the bottom end of the screw rod (28), two second bevel gears (34) are arranged on the linkage shaft (35), and the driving motor (36) is fixedly installed on the shaking base (1).
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| CN202210714823.5A CN115138274B (en) | 2022-06-23 | 2022-06-23 | Shaking mixing system for preparation of tetravalent influenza virus subunit vaccine |
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| CN202210714823.5A CN115138274B (en) | 2022-06-23 | 2022-06-23 | Shaking mixing system for preparation of tetravalent influenza virus subunit vaccine |
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| CN115138274B true CN115138274B (en) | 2023-11-10 |
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| CN114130265A (en) * | 2020-09-02 | 2022-03-04 | 浙江康是医疗器械有限公司 | Portable high-efficiency shaking and conveying device for peripheral blood collection tubes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE102004021665B4 (en) * | 2004-05-03 | 2006-06-14 | H+P Labortechnik Ag | Shaker for sample vessels and method for shaking sample vessels |
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|---|---|---|---|---|
| JPH08226120A (en) * | 1995-02-22 | 1996-09-03 | Tenox Corp | Excavation and agitation mixing device |
| JP2014001594A (en) * | 2012-06-20 | 2014-01-09 | Hiroshi Kurabayashi | Multistage vibration control device having multiple degree of freedom |
| CN211659880U (en) * | 2020-01-17 | 2020-10-13 | 上海汉尼生物细胞技术有限公司 | Reagent mixing arrangement for slow virus packing experiments |
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| CN115138274A (en) | 2022-10-04 |
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