CN115138274A - Tetravalent influenza virus subunit vaccine preparation shaking mixing system - Google Patents
Tetravalent influenza virus subunit vaccine preparation shaking mixing system Download PDFInfo
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- CN115138274A CN115138274A CN202210714823.5A CN202210714823A CN115138274A CN 115138274 A CN115138274 A CN 115138274A CN 202210714823 A CN202210714823 A CN 202210714823A CN 115138274 A CN115138274 A CN 115138274A
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- 229940031626 subunit vaccine Drugs 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 241000712461 unidentified influenza virus Species 0.000 title abstract description 10
- 241000700605 Viruses Species 0.000 claims abstract description 84
- 230000003014 reinforcing effect Effects 0.000 claims abstract description 13
- 230000002146 bilateral effect Effects 0.000 claims abstract description 4
- 230000001360 synchronised effect Effects 0.000 claims abstract description 3
- 230000007306 turnover Effects 0.000 claims description 38
- 238000009434 installation Methods 0.000 claims description 15
- 238000005253 cladding Methods 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 11
- 206010022000 influenza Diseases 0.000 claims description 10
- 230000035939 shock Effects 0.000 claims description 9
- 230000003139 buffering effect Effects 0.000 claims description 7
- 230000033001 locomotion Effects 0.000 claims description 4
- 230000009467 reduction Effects 0.000 claims description 3
- 238000003466 welding Methods 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 2
- 238000005728 strengthening Methods 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims 1
- 230000002779 inactivation Effects 0.000 abstract description 13
- 238000013016 damping Methods 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 7
- 229960005486 vaccine Drugs 0.000 description 10
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 230000000937 inactivator Effects 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 2
- 229960003971 influenza vaccine Drugs 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a tetravalent influenza virus subunit vaccine preparation shaking mixing system which comprises a shaking base, wherein a vertical support is fixedly installed on the shaking base, a slope groove is formed in the shaking base, reinforcing ribs are fixedly installed on the vertical support, a layering plate is fixedly installed between the vertical support and the reinforcing ribs, a spring rod is fixedly installed on the vertical support, a hanging piece is installed on the spring rod in a sliding mode, the hanging piece is fixedly connected to a movable plate, a multi-stage pushing structure is arranged on the movable plate, a limiting seat is fixedly installed on the layering plate, a sliding rod is installed in the limiting seat in a sliding mode, a damping top plate is fixedly connected to the sliding rod, and a jacking structure with a bilateral synchronous control function is installed on the shaking base; the shaking mixing system is used for accelerating the inactivation process of the virus, can shake the virus tank, can gradually reduce the amplitude from top to bottom, and is not easy to cause excessive inactivation of the virus.
Description
Technical Field
The invention relates to the technical field of vaccine preparation, in particular to a tetravalent influenza virus subunit vaccine preparation shaking mixing system.
Background
In the process of human growth, multiple vaccinations are often carried out, human immunity is formed through different vaccines, external virus invasion is responded, and the probability of illness occurrence or the serious illness rate is reduced. The influenza vaccine is a vaccine developed mainly aiming at influenza and is one of common vaccines for children. The tetravalent influenza virus subunit vaccine is a component vaccine containing a new antigen form, has the characteristics of high purity, low side effect of inoculation and good safety, and is suitable for children and the elderly. Clinical data show that the vaccine is safe and effective and can provide wider and sufficient protection for society in the aspect of preventing seasonal influenza viruses.
The tetravalent influenza virus subunit vaccine is an inactivated vaccine, and during the production and preparation process, the virus is firstly cultured and then inactivated, so that the safe and reliable influenza vaccine is obtained. At present, two modes of inactivators or high-temperature treatment are generally adopted for virus inactivation, and after the inactivators are added into a virus reagent, the inactivators and the virus reagent need to be ensured to be in uniform contact, so that a good inactivation effect is achieved. However, the mixing systems used at present are all single stirring or shaking mechanisms, so that the mixing degree is difficult to control, and the over-reaction condition is easy to occur, so that the vaccine is ineffective.
Disclosure of Invention
The invention aims to provide a shaking mixing system for preparing tetravalent influenza virus subunit vaccine, so as to achieve the purposes of gradually decelerating and shaking and limiting the virus inactivation degree, and solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a tetravalent influenza virus subunit vaccine preparation shaking mixing system comprises a shaking base, wherein a vertical bracket is fixedly arranged on the shaking base, and the shaking base is provided with a slope groove, the vertical bracket is provided with a plurality of reinforcing ribs from top to bottom in a welding way, and the reinforcing ribs are fixedly provided with a layering plate, the vertical support is divided into a plurality of working spaces by the reinforcing ribs and the layering plate, the middle part of the layering plate is provided with a through groove, an overturning support plate is rotatably arranged in the through groove, a limit strip is fixedly arranged on the overturning support plate, a virus tank is arranged on the overturning support plate, a back plate is fixedly arranged on the vertical support, a limiting spring is fixedly connected on the back plate, an installation seat is fixedly connected on the limiting spring, a limiting piece is fixedly installed on the installation seat, a spring rod is fixedly installed on the vertical support, and the spring rod is provided with a hanging piece in a sliding way, the hanging piece is fixedly connected to the movable plate, the connecting rod and the driving disc form a crank block structure, the connecting rod is connected to the back of the movable plate through a rotating shaft, the driving disc rotates to drive the movable plate to reciprocate, the movable plate is provided with a multi-stage pushing structure, and the multistage pushing structure is provided with a push plate with a limit position gradually shrinking inwards from top to bottom along the direction of the vertical bracket, the effect of pushing the virus tank to move for different distances in a layering way is realized, the layering plate is fixedly provided with a limit seat, a sliding rod is slidably arranged in the limiting seat, a damping top plate and a triangular block are fixedly connected to the sliding rod, and a return spring is fixedly connected to the triangular block, a jacking structure with bilateral synchronous control function is installed on the shaking base, and the triangular block is pushed from bottom to top to realize the layer-by-layer opening and closing of the turnover support plate.
Preferably, wave the base bottom and be provided with the stabilizer blade, and erect the support and constitute by four vertical members, constitute square passage shaking base top, and the slope groove sets up the bottom at square passage, the strengthening rib is installed in the bottom of layering board, and the layering board is provided with four at least along erecting support equidistance arrangement, the mirror image of upset extension board is provided with two on every layering board, and the upset extension board passes through hinged joint installation, the upper surface at the upset extension board is installed to spacing.
Preferably, the back plate is installed between two rod pieces of the vertical support, the limiting spring is installed on one surface, facing the layering plate, of the back plate, the limiting pieces are installed on the installation seat through screws, the limiting pieces are provided with arc-shaped surfaces with cushion layers, the limiting pieces are vertically arranged, and the number of the limiting pieces is consistent with that of the layering plate.
Preferably, the spring rods are vertically connected to the two rod pieces of the vertical support, the hanging piece is mounted on the spring rods in a limiting and sliding mode, the hanging piece is mounted on the back face of the movable plate, the connecting rod and the driving disc form a crank block structure, and the driving disc is driven by the speed reduction motor.
Preferably, multistage promotion structure is including arranging the threaded rod that sets up along the fly leaf, and has cup jointed balance spring on the threaded rod, balance spring one end is connected on the cladding, and the other end is connected on the fly leaf, and the cladding passes through the through-hole and hangs on the threaded rod, threaded connection has adjusting nut on the threaded rod, and adjusting nut presses the push pedal on balance spring, fixed mounting has the buffering strip in the push pedal.
Preferably, the threaded rod sets up in pairs for two liang, has carried out the balance of push pedal through two threaded rods and has articulated, and the push pedal is located between two adjacent layering boards from top to bottom, and the push pedal is connected between two cladding boards, balance spring's both ends are connected respectively on fly leaf and push pedal, and the buffering strip bonds on the push pedal surface.
Preferably, spacing seat is installed in the bottom of layering board, and is provided with the spout on the spacing seat, the slide bar runs through the spout and installs, and shock attenuation roof and three hornblocks connect respectively at the both ends of slide bar, the support of upset backup pad is pushed up in the bottom of upset backup pad to the shock attenuation roof, and reset spring's both ends are connected respectively on three hornblocks and layering board.
Preferably, the roof pressure structure is including rotating lead screw and the guide bar of fixed mounting on shaking the base of installing on shaking the base, and has carried out the installation of nut seat on lead screw and the guide bar, the one-way rotation is installed and is rolled over a support on the nut seat, and turns over a fixed mounting and have the push rod on the support, fixed mounting has first bevel gear on the lead screw, and the meshing installs second bevel gear on the first bevel gear, second bevel gear fixed mounting is on the universal driving shaft, and universal driving shaft fixed connection is on driving motor.
Preferably, the guide bar sets up the both sides at the lead screw, guide bar and lead screw are provided with two sets ofly at the bilateral symmetry of layering board, and nut seat threaded connection is on the lead screw to connect on the guide bar through the slide opening, turn over a support and be provided with the dog through the pivot installation, and turn over a support below, the push rod is installed and is being turned over the tip of a support, first bevel gear installs in the bottom of lead screw, and second bevel gear is provided with two on the universal driving shaft, driving motor fixed mounting is on shaking the base.
Compared with the prior art, the invention has the beneficial effects that:
1. the shaking mixing system is used for accelerating the inactivation process of viruses, a vertical channel is formed by the vertical supports, a plurality of layered plates are arranged in the channel at equal intervals, virus tanks with viruses and inactivators can be placed, the virus tanks can be shaken on the layered plates, and then the mixing of the reagents and the viruses is accelerated.
2. The invention can ensure that the virus tanks can rock in a certain range, one side of the vertical support is provided with the limiting structure, the other side of the vertical support is provided with the driving mechanism, the movable plate can perform rapid reciprocating linear motion, and the movable plate is provided with the multistage pushing structure towards one side of the virus tanks.
3. According to the invention, the virus tank is supported through the overturning support plate, the overturning support plate is set to be of an openable structure, when the position is changed, the triangular block is pushed out through the jacking structure from the lowermost layered plate, the damping top plate is pulled by the sliding rod to move outwards, and the triangular block is separated from the lower part of the overturning support plate, so that the virus tank on the overturning support plate falls, the overturning support plate is opened layer by layer, the virus tank also falls layer by layer, and the vacancy of the lower part is ensured.
Drawings
Fig. 1 is a first schematic view of the overall structure of the present invention.
Fig. 2 is a second schematic view of the overall structure of the present invention.
FIG. 3 is a schematic view of the base structure of the present invention.
Fig. 4 is a schematic view of a multi-level rocking structure of the present invention.
Fig. 5 is a schematic view of a single-stage rocking structure of the present invention.
FIG. 6 is a schematic diagram of a pushing structure according to the present invention.
Fig. 7 is a schematic view of the support structure of the present invention.
Fig. 8 is a schematic view of the pitch adjusting structure of the present invention.
FIG. 9 is a schematic view of an opening mechanism of the present invention.
Fig. 10 is an enlarged view of the area a in fig. 8.
In the figure: the device comprises a shaking base 1, a vertical support 2, a slope groove 3, a reinforcing rib 4, a layering plate 5, a turning support plate 6, a limiting strip 7, a back plate 8, a limiting spring 9, an installation seat 10, a limiting piece 11, a spring rod 12, a hanging piece 13, a movable plate 14, a connecting rod 15, a driving disc 16, a threaded rod 17, a balance spring 18, an outer hanging plate 19, an adjusting nut 20, a push plate 21, a buffering strip 22, a limiting seat 23, a sliding rod 24, a damping top plate 25, a triangular block 26, a return spring 27, a lead screw 28, a guide rod 29, a nut seat 30, a turning support 31, a push rod 32, a first bevel gear 33, a second bevel gear 34, a linkage shaft 35 and a driving motor 36.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and the detailed description, wherein various embodiments or technical features described below can be arbitrarily combined to form a new embodiment without conflict, and it should be understood that the described embodiments are only a part of embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1 to 10, the present invention provides a technical solution: a tetravalent influenza virus subunit vaccine preparation shaking mixing system comprises a shaking base 1, a vertical support 2 is fixedly installed on the shaking base 1, a slope groove 3 is arranged on the shaking base 1, a plurality of reinforcing ribs 4 are arranged on the vertical support 2 from top to bottom in a welding mode, a layering plate 5 is fixedly installed on the reinforcing ribs 4, the vertical support 2 is divided into a plurality of working spaces by the reinforcing ribs 4 and the layering plate 5, a through groove is formed in the middle of the layering plate 5, a turning support plate 6 is rotatably installed in the through groove, a limiting strip 7 is fixedly installed on the turning support plate 6, a virus tank is placed on the turning support plate 6, a back plate 8 is fixedly installed on the vertical support 2, a limiting spring 9 is fixedly connected onto the back plate 8, a mounting seat 10 is fixedly connected onto the limiting seat 10, a limiting part 11 is fixedly installed on the mounting seat 10, a spring rod 12 is fixedly installed on the vertical support 2, a pendant 13 is slidably installed on the spring rod 12, the pendant 13 is fixedly connected onto a movable plate 14, a driving disk 14 and a connecting rod 15, the driving disk 16 forms a crank block structure, the connecting rod 15 is connected onto a movable plate 14, a movable plate 24, a triangular block 23 is installed on the back of the movable plate, a movable plate 24 and a triangular block 23, the triangular block 23 is connected onto the triangular plate 24, the triangular block 23 and a triangular block 23, the triangular plate 24 and a top plate 23 are arranged on the triangular plate 23, the triangular block capable of pushing plate capable of gradually, the triangular block capable of pushing the triangular plate and pushing the triangular plate capable of gradually, the turning support plate 6 is opened and closed layer by pushing the triangular block 26 from bottom to top.
The bottom of the shaking base 1 is provided with support legs, the vertical support 2 is composed of four vertical rod pieces, a square channel is formed above the shaking base 1, the slope groove 3 is formed in the bottom of the square channel, the reinforcing ribs 4 are arranged at the bottom of the layered plate 5, the layered plate 5 is provided with at least four pieces in an equidistant arrangement mode along the vertical support 2, the number of the turnover support plates 6 on each layered plate 5 is two, the turnover support plates 6 are mounted through hinges, and the limiting strips 7 are mounted on the upper surfaces of the turnover support plates 6.
The shaking mixing system is used for accelerating the inactivation process of viruses, a shaking base 1 is used as a basic structure, a vertical channel is formed by a vertical support 2, a plurality of layered plates 5 are arranged in the channel at equal intervals, a turning support plate 6 is arranged at the central position of each layered plate 5, when the two turning support plates 6 are closed, virus tanks with viruses and inactivators can be placed, and the virus tanks can move along the direction of a limit strip 7, so that the reagents in the virus tanks are shaken to accelerate virus inactivation, and particularly, the shaking amplitude of the virus tanks on each layered plate is different and can be gradually reduced from top to bottom, so that each virus tank firstly shakes from the top at the maximum amplitude and then falls step by step to reduce the shaking amplitude, and finally slides out from a slope groove 3, limited shaking mixing work is completed, excessive virus inactivation is not easy to cause, and the effect of vaccines is ensured; in a traditional shaking system, a single virus tank is always shaken continuously, the degree of inactivation is controlled by adjusting the shaking speed, the system is low in efficiency and needs to be stopped during material changing and cleaning, and the problems of excessive inactivation and insufficient activity of vaccines are easily caused.
The backplate 8 is installed between two member bars of erecting support 2, and spacing spring 9 installs in the backplate 8 one side towards layering board 5, and locating part 11 passes through the mounting screw and installs on mount pad 10, and locating part 11 is provided with the arc surface of taking the bed course, and the vertical range setting of locating part 11, and its quantity keeps unanimous with layering board 5.
The virus tank is placed on the layered plate 5, and in order to achieve the effect of shaking and mixing, the virus tank is further required to be driven and limited, the virus tank is guaranteed to shake within a certain range, therefore, the back plate 8 is installed on one side of the vertical support 2, the limiting part 11 is installed on the back plate through the limiting spring 9 and the installation seat 10, and the virus tank can be abutted to the virus tank to limit the position of the virus tank.
The spring rods 12 are vertically connected to two rod pieces of the vertical support 2, the hanging pieces 13 are mounted on the spring rods 12 in a limiting sliding mode, the hanging pieces 13 are mounted on the back of the movable plate 14, the connecting rods 15 and the driving disc 16 form a crank-slider structure, and the driving disc 16 is driven by the speed reduction motor.
On the other side of the vertical support 2, the opposite side of the back plate 8 is provided with a driving mechanism, a crank slider structure is formed by a movable plate 14, a connecting rod 15 and a driving disc 16, and when the driving disc 16 rotates, the movable plate 14 can be driven to perform rapid reciprocating linear motion along the direction of the spring rod 12.
Multistage promotion structure is including arranging the threaded rod 17 that sets up along fly leaf 14, and has cup jointed balance spring 18 on the threaded rod 17, and balance spring 18 one end is connected on cladding board 19, and the other end is connected on fly leaf 14, and cladding board 19 hangs on threaded rod 17 through the through-hole, and threaded connection has adjusting nut 20 on the threaded rod 17, and adjusting nut 20 presses push pedal 21 on balance spring 18, and fixed mounting has buffering strip 22 on the push pedal 21.
The movable plate 14 is mounted with a multistage pushing structure on the side facing the virus tanks, so that different pushing effects can be generated for the virus tanks on different layering plates 5 when the moving distances of the movable plate 14 are the same, and the shaking range of the virus tank on the upper layer is always larger than that of the virus tank on the lower layer;
threaded rod 17 is two liang setting in pairs, has carried out the balance of push pedal 21 through two threaded rods 17 and has articulated, and push pedal 21 is located between two adjacent layering boards 5 from top to bottom, and push pedal 21 connects between two cladding boards 19, and balance spring 18's both ends are connected respectively on fly leaf 14 and push pedal 21, and buffering strip 22 bonds on push pedal 21 surface.
Multistage promotion structure mainly comprises many pairs of screw rod 17 and installs the basis installation, the movable mounting of cladding 19 has been carried out on it, and push pedal 21 installs on cladding 19, rotation through adjusting nut 20, reach balanced with balance spring 18, the extreme position that cladding 19 and push pedal 21 inwards has been adjusted, adjust through the push pedal 21 position to each layer, from top to bottom inwards contracts, push pedal 21 on upper strata can push away in fly leaf 14, earlier promote with the contact of virus jar, promote bigger distance with it, consequently, the virus jar on upper strata shakes the range bigger, the successive layer reduces, and the difference of the range of shaking of each layer can carry out further regulation through adjusting nut 20.
The supporting of the virus tank is carried out on the layering plate 5 through the turning support plate 6, and as the virus tank is required to be ensured to gradually fall onto the layering plate 6 at the lower layer, the virus tank is pushed by different amplitudes and gradually subjected to speed-reducing shaking, the turning support plate 6 is set to be of an openable structure, when the position is exchanged, the triangular block 26 is pushed outwards through the jacking structure from the layering plate 5 at the lowest layer, the shock absorption top plate 25 is pulled to move outwards through the sliding rod 24 and is separated from the lower part of the turning support plate 6, so that the virus tank on the turning support plate 6 falls, the turning support plate 6 is opened layer by layer, the virus tank also falls layer by layer, and the condition that a vacancy is formed at the beginning of the lower part is ensured; the virus tank adopts the plastic tank of bottom thickening, has certain deformation shock-absorbing capacity to turn over and be provided with the cushion layer on the extension board 6, be used for supporting the shock attenuation roof 25 that turns over extension board 6 and also adopt shock-absorbing structure, can effectually guarantee that the virus tank is gentle falls on turning over extension board 6, prevent that the virus tank is damaged.
The jacking structure comprises a screw rod 28 rotatably installed on a shaking base 1 and a guide rod 29 fixedly installed on the shaking base 1, a nut seat 30 is installed on the screw rod 28 and the guide rod 29, a turnover support 31 is installed on the nut seat 30 in a one-way rotating mode, a push rod 32 is fixedly installed on the turnover support 31, a first bevel gear 33 is fixedly installed on the screw rod 28, a second bevel gear 34 is installed on the first bevel gear 33 in a meshed mode, the second bevel gear 34 is fixedly installed on a linkage shaft 35, and the linkage shaft 35 is fixedly connected to a driving motor 36.
The jacking structure is a reciprocating structure, the triangular block 26 and the shock-absorbing top plate 25 are pushed from bottom to top during working, the turnover support plate 6 can complete an opening and closing process layer by layer, the switching position of the virus tank is assisted, and the triangular block 26 cannot be influenced when the turnover support plate is reset from top to bottom.
The guide rods 29 are arranged on two sides of the screw rod 28, two groups of guide rods 29 and two groups of screw rods 28 are symmetrically arranged on two sides of the layered plate 5, the nut seats 30 are in threaded connection with the screw rod 28 and are connected to the guide rods 29 through sliding holes, the turnover support 31 is installed through a rotating shaft, a stop block is arranged below the turnover support 31, the push rod 32 is installed at the end of the turnover support 31, the first bevel gear 33 is installed at the bottom end of the screw rod 28, the number of the second bevel gears 33 is two on the linkage shaft 35, and the driving motor 36 is fixedly installed on the shaking base 1.
Specifically, the linkage shaft 35 is driven to rotate by the driving motor 36, the lead screw 28 is driven to rotate by the transmission of the second bevel gear 33 and the first bevel gear 32, the nut seat 30 on the lead screw 28 moves from bottom to top, the triangular block 26 is located on the moving route of the nut seat 30, the turning support 31 on the nut seat 30 is limited by the stopper, the nut seat 26 cannot rotate when pushed from below, the turning support 31 on the nut seat 30 moves to a position in contact with the bottom inclined surface of the triangular block 26, the pushing rod 32 on the turning support 31 generates pushing force along the bottom inclined surface direction of the triangular block 26 as the turning support 31 continuously moves upwards, the triangular block 26 has a tendency of moving upwards along the force direction, and meanwhile, the triangular block 26 is limited by the sliding rod 24 in the vertical direction, so that the pushing rod 32 can push the triangular block 26, the sliding rod 24 drives the damping top plate 25 to move, the turning support plate moves away from the lower side of the turning support 6, and the nut seat 30 is also provided with two turning support plates 6 which can simultaneously drive the two turning support plates 6 to open, so that the virus can fall off, otherwise, the nut seat 30 can be driven by the driving motor 36, and the turning support 31 can avoid the influence on the turning support plate 31; the nut seat 30 and the push rod 32 thereon are used for sequentially pushing all the triangular blocks 26 from bottom to top, so that the turnover support plates 6 are sequentially opened one by one, the virus can rapidly drops, after the push rod 32 is separated from the triangular blocks 26, the damping top plate 25 can reset under the action of the reset spring 27, the turnover support plates 6 are rapidly reset, the nut seat 30 can continuously move upwards to open an upper layer of turnover support plates 6, and a certain distance is reserved between the triangular blocks 26 of each layer of turnover support plate 6, so that the turnover support plates 6 can be reset for enough time, and the condition that the upper layer of turnover support plates 6 are opened and the lower layer of turnover support plates 6 are not reset is avoided; only after the layer changing work of the virus tank in the whole shaking system is completed, the driving motor drives the screw rod 28 to rotate reversely, so that the nut seat 30 moves downwards from the uppermost direction to reset.
When the invention is used: firstly, the shaking mixing system of the invention is used for accelerating the inactivation process of virus, which takes a shaking base 1 as a basic structure, a vertical channel is formed by a vertical bracket 2, a plurality of layered plates 5 are arranged in the channel at equal intervals, a turning support plate 6 is arranged at the central position of the layered plates 5, when the two turning support plates 6 are closed, the virus tank with virus and inactivating agent can be placed, and the virus tank can move along the direction of a limit strip 7, and then the reagent in the virus tank is shaken to accelerate virus inactivation, in particular, the shaking amplitude of the virus tank on each layered plate is different and can be gradually reduced from top to bottom, therefore, each virus tank firstly shakes from the top with the maximum amplitude, then falls step by step, reduces the shaking amplitude, finally slides out from a slope groove 3, and completes limited shaking mixing work, the virus can is not easily inactivated excessively, the effect of vaccine is ensured, the virus can is placed on the layered plate 5, in order to achieve the effect of shaking and mixing, the driving and limiting of the virus can are required, the virus can is guaranteed to shake within a certain range, therefore, the back plate 8 is installed on one side of the vertical support 2, the limiting part 11 is installed on the vertical support through the limiting spring 9 and the installation seat 10, the vertical support can be propped against the virus can for limiting the virus can, the opposite surface of the back plate 8 on the other side of the vertical support 2 is provided with the driving mechanism, the movable plate 14, the connecting rod 15 and the driving disc 16 form a crank-slider structure, when the driving disc 16 rotates, the movable plate 14 can be driven to perform rapid reciprocating linear motion along the direction of the spring rod 12, and the movable plate 14 performs the installation of a multi-stage pushing structure towards one side of the virus can, aiming at the virus tanks on different layered plates 5, when the moving distances of the movable plates 14 are the same, pushing effects with different amplitudes are generated, so that the shaking amplitude of the virus tank on the upper layer is always larger than that of the virus tank on the lower layer, the multistage pushing structure mainly comprises a plurality of pairs of threaded rods 17 which form basic installation, the outer hanging plate 19 is movably installed on the basic installation, the push plate 21 is installed on the outer hanging plate 19 and is balanced with the balance spring 18 through the rotation of the adjusting nut 20, inward limit positions of the outer hanging plate 19 and the push plate 21 are adjusted, the position of the push plate 21 on each layer is adjusted to be inwards contracted from top to bottom, when the push plate 21 on the upper layer is pushed inwards by the movable plates 14, the push plate is firstly contacted with the virus tank to be pushed, the distance is larger, therefore, the shaking amplitude of the virus tank on the upper layer is larger, the layer by layer is reduced, and the shaking amplitude difference of each layer can be further adjusted through the adjusting nut 20, the layer board 5 is supported by the turnover support board 6, and the virus tank is ensured to gradually fall on the layer board 6 at the lower layer, and is pushed by different amplitudes to gradually perform speed-reducing shaking, so the turnover support board 6 is set to be an openable structure, when the position is changed, the triangular block 26 is pushed out by a jacking structure from the lowest layer board 5, the damping top board 25 is pulled by the slide rod 24 to move outwards to be separated from the lower part of the turnover support board 6, the virus tank on the turnover support board 6 is further dropped, the turnover support board 6 is opened layer by layer, the virus tank also falls layer by layer, and the vacancy is ensured at the end of the lower part, the jacking structure is a reciprocating structure, when the turnover support board 6 works, the triangular block 26 and the damping top board 25 are pushed from bottom to top, so that the turnover support board 6 can complete an opening and closing process layer by layer, the position of the virus can is switched, when the virus can is reset from top to bottom, the virus can not be influenced on the triangular block 26, specifically, the driving motor 36 drives the linkage shaft 35 to rotate, the screw rod 28 is driven to rotate through the transmission of the second bevel gear 33 and the first bevel gear 32, the nut seat 30 on the screw rod 28 moves from bottom to top, the turnover support 31 on the nut seat 30 is limited by the stop block and cannot rotate when the triangular block 26 is pushed from the bottom, therefore, the push rod 32 can push the triangular block 26, the nut seat 30 is also provided with two, the two turnover support plates 6 can be driven to be opened at the same time, so that the virus can on the turnover support plate can drop, otherwise, when the driving motor 36 drives the nut seat 30 to reset, the turnover support 31 can be turned over, and the influence of the push rod 32 on the turnover support plates 6 is avoided.
The above embodiments are merely preferred embodiments of the present invention, and the scope of the present invention should not be limited thereto, and those skilled in the art will be able to make various modifications without inventive changes from the above concepts and the scope of the present invention.
Claims (9)
1. A tetravalent influenza subunit vaccine preparation shakes hybrid system, includes shaking base (1), its characterized in that: the multifunctional rocking device is characterized in that a vertical support (2) is fixedly mounted on the rocking base (1), a slope groove (3) is arranged on the rocking base (1), a plurality of reinforcing ribs (4) are arranged on the vertical support (2) from top to bottom in a welding mode, a layering plate (5) is fixedly mounted on the reinforcing ribs (4), the reinforcing ribs (4) and the layering plate (5) divide the vertical support (2) into a plurality of working spaces, a through groove is formed in the middle of the layering plate (5), a turnover support plate (6) is rotatably mounted in the through groove, a limiting strip (7) is fixedly mounted on the turnover support plate (6), a virus can is placed on the turnover support plate (6), a back plate (8) is fixedly mounted on the vertical support (2), a limiting spring (9) is fixedly connected to the back plate (8), a mounting seat (10) is fixedly connected to the limiting spring (9), a limiting piece (11) is fixedly mounted on the mounting seat (10), a spring rod (12) is fixedly mounted on the vertical support (2), a hanging piece (13) is fixedly connected to the spring rod (12), a hanging piece (13) is fixedly connected to the movable plate (14), a connecting rod (14) and a crank connecting rod (15) and a crank connecting rod (14) and a crank connecting rod (16) and a crank connecting rod (14) and a connecting rod (16) and a crank connecting rod (16), rotate through driving-disc (16) and drive fly leaf (14) reciprocating motion, be provided with multistage promotion structure on fly leaf (14), and multistage promotion structure along the direction of erecting support (2), from top to bottom be provided with extreme position push pedal (21) that draw gradually inwards, realize that the layering promotes the effect that the viral tank removed different distances, fixed mounting has spacing seat (23) on layering board (5), and slidable mounting has slide bar (24) in spacing seat (23), fixedly connected with shock attenuation roof (25) and triangle block (26) on slide bar (24), and fixedly connected with reset spring (27) on triangle block (26), install the top pressure structure that has two side synchronous control functions on waveing base (1), through by supreme three triangle blocks (26) of promotion down, realize the successive layer switching of upset extension board (6).
2. A tetravalent influenza subunit vaccine preparation shake mixing system of claim 1, characterized by: wave base (1) bottom and be provided with the stabilizer blade, and erect support (2) and constitute by four vertical members, constitute square passageway shaking base (1) top, and slope groove (3) set up the bottom at square passageway, the bottom at layering board (5) is installed in strengthening rib (4), and layering board (5) are arranged along erecting support (2) equidistance and are provided with four at least, upset extension board (6) mirror image is provided with two on every layering board (5), and upset extension board (6) pass through the hinge mount, the upper surface at upset extension board (6) is installed in spacing (7).
3. A tetravalent influenza subunit vaccine preparation shake mixing system of claim 1, characterized by: the back plate (8) is installed between two rod pieces of the vertical support (2), the limiting spring (9) is installed on one surface, facing the layering plate (5), of the back plate (8), the limiting piece (11) is installed on the installation seat (10) through a screw, the limiting piece (11) is provided with an arc-shaped surface with a cushion layer, the limiting piece (11) is vertically arranged, and the number of the limiting piece and the number of the layering plate (5) are kept consistent.
4. A tetravalent influenza subunit vaccine preparation shake mixing system of claim 1, wherein: the spring rod (12) is vertically connected to the two rod pieces of the vertical support (2), the hanging piece (13) is mounted on the spring rod (12) in a limiting sliding mode, the hanging piece (13) is mounted on the back face of the movable plate (14), the connecting rod (15) and the driving disc (16) form a crank-slider structure, and the driving disc (16) is driven through the speed reduction motor.
5. A tetravalent influenza subunit vaccine preparation shake mixing system of claim 1, characterized by: multistage promotion structure is including arranging threaded rod (17) that sets up along fly leaf (14), and has cup jointed balance spring (18) on threaded rod (17), balance spring (18) one end is connected on cladding board (19), and the other end is connected on fly leaf (14), and cladding board (19) hang on threaded rod (17) through the through-hole, threaded connection has adjusting nut (20) on threaded rod (17), and adjusting nut (20) presses push pedal (21) on balance spring (18), fixed mounting has buffering strip (22) on push pedal (21).
6. A tetravalent influenza subunit vaccine preparation shake mixing system of claim 5, characterized by: threaded rod (17) are two liang set up in pairs, have carried out the balance of push pedal (21) through two threaded rod (17) and have articulated, and push pedal (21) are located between two adjacent layering board (5) from top to bottom, and push pedal (21) are connected between two cladding board (19), the both ends of balance spring (18) are connected respectively on fly leaf (14) and push pedal (21), and buffering strip (22) bond on push pedal (21) surface.
7. A tetravalent influenza subunit vaccine preparation shake mixing system of claim 1, characterized by: spacing seat (23) are installed in the bottom of layering board (5), and are provided with the spout on spacing seat (23), slide bar (24) run through the spout and install, and shock attenuation roof (25) and three hornblocks (26) are connected respectively at the both ends of slide bar (24), shock attenuation roof (25) top is in the bottom of upset extension board (6), the support of upset extension board (6), and reset spring (27)'s both ends are connected respectively on three hornblocks (26) and layering board (5).
8. A tetravalent influenza subunit vaccine preparation shake mixing system of claim 1, characterized by: the jacking structure is including rotating lead screw (28) and the guide bar (29) of fixed mounting on shaking base (1) of installing on shaking base (1), and has carried out the installation of nut seat (30) on lead screw (28) and guide bar (29), one-way rotation is installed and is turned over a support (31) on nut seat (30), and turns over a fixed mounting and have push rod (32) on support (31), fixed mounting has first bevel gear (33) on lead screw (28), and meshing installs second bevel gear (34) on first bevel gear (33), second bevel gear (34) fixed mounting is on universal driving shaft (35), and universal driving shaft (35) fixed connection is on driving motor (36).
9. A tetravalent influenza subunit vaccine preparation shake mixing system of claim 8, characterized by: guide bar (29) sets up the both sides in lead screw (28), guide bar (29) and lead screw (28) are provided with two sets ofly at the bilateral symmetry of layering board (5), and nut seat (30) threaded connection is on lead screw (28) to connect on guide bar (29) through the slide opening, turn over a support (31) and install through the pivot, and turn over a support (31) below and be provided with the dog, push rod (32) are installed at the tip of turning over a support (31), the bottom at lead screw (28) is installed in first bevel gear (33), and second bevel gear (33) are provided with two on universal driving shaft (35), driving motor (36) fixed mounting is on shaking base (1).
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| CN202210714823.5A CN115138274B (en) | 2022-06-23 | 2022-06-23 | Shaking mixing system for preparation of tetravalent influenza virus subunit vaccine |
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| CN202210714823.5A CN115138274B (en) | 2022-06-23 | 2022-06-23 | Shaking mixing system for preparation of tetravalent influenza virus subunit vaccine |
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| CN115138274B CN115138274B (en) | 2023-11-10 |
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| CN212985907U (en) * | 2020-09-02 | 2021-04-16 | 鄂尔多斯市国源矿业开发有限责任公司 | Damping device for mining electromechanical equipment |
| CN213854334U (en) * | 2020-11-09 | 2021-08-03 | 广东省微生物研究所（广东省微生物分析检测中心） | Detect reagent and vibrate mixing arrangement |
| CN114130265A (en) * | 2020-09-02 | 2022-03-04 | 浙江康是医疗器械有限公司 | Portable high-efficiency shaking and conveying device for peripheral blood collection tubes |
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2022
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08226120A (en) * | 1995-02-22 | 1996-09-03 | Tenox Corp | Excavation and agitation mixing device |
| US20080159062A1 (en) * | 2004-05-03 | 2008-07-03 | Thermo Electron (Oberschleissheim) Gmbh | Shaking Apparatus For Sample Containers |
| JP2014001594A (en) * | 2012-06-20 | 2014-01-09 | Hiroshi Kurabayashi | Multistage vibration control device having multiple degree of freedom |
| CN211659880U (en) * | 2020-01-17 | 2020-10-13 | 上海汉尼生物细胞技术有限公司 | Reagent mixing arrangement for slow virus packing experiments |
| CN212985907U (en) * | 2020-09-02 | 2021-04-16 | 鄂尔多斯市国源矿业开发有限责任公司 | Damping device for mining electromechanical equipment |
| CN114130265A (en) * | 2020-09-02 | 2022-03-04 | 浙江康是医疗器械有限公司 | Portable high-efficiency shaking and conveying device for peripheral blood collection tubes |
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|---|---|
| CN115138274B (en) | 2023-11-10 |
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