CN115120810A - Medicine injection pump based on electrochemical reaction and manufacturing method thereof - Google Patents

Abstract

The application provides a drug injection pump based on electrochemical reaction and a manufacturing method thereof. The driving part is positioned in the medicine storage part and used for generating pushing force for the medicine storage part by utilizing current based on an electrochemical principle; the medicine storage part is internally loaded with medicine liquid and is used for pushing the medicine liquid out under the pushing of the driving part and injecting the medicine liquid to a patient. Because the electrochemical reaction can be generated based on the electric signal of a preset rule, the injection on time can be realized for a patient by controlling the input current or voltage, thereby ensuring the stability, intelligence and automation of the administration.

Description

Medicine injection pump based on electrochemical reaction and manufacturing method thereof

Technical Field

The application relates to the technical field of medical instruments, in particular to a drug injection pump based on electrochemical reaction and a manufacturing method thereof.

Background

In the medical field, some patients need to frequently inject corresponding medicines for a long time for special reasons so as to meet the requirements of keeping the body stable and healthy for corresponding functions, such as continuous analgesia for operation patients or pain patients, or continuous stability when insulin supplementation and administration are required for diabetes patients. At present, medical staff or patients carry out manual injection administration at certain time intervals, and the stability of administration cannot be ensured because the manual operation is difficult to strictly comply with the time requirement; and manual operation can not adjust the administration time and the injection amount of the medicine, and can not meet the actual requirements of different individuals, thereby being incapable of realizing the intellectualization and automation of administration.

Disclosure of Invention

In order to solve the problems, the application provides a drug injection pump based on electrochemical reaction and a manufacturing method thereof, so as to solve the problem that the drug injection stability cannot be ensured by manual injection of the drug and solve the problems of intellectualization and automation of the drug administration process.

In view of the above, the present application discloses an electrochemical-based drug infusion pump comprising a drive component and a drug storage component, wherein:

the driving component is arranged inside the medicine storage component and used for generating a driving force based on an electrochemical reaction principle, the driving force is applied inside the medicine storage component, the driving component comprises an electrochemical element, the electrochemical element is connected to the outside of the medicine storage component through a lead and used for receiving preset current, the electrochemical element is used for generating gas based on the preset current, the gas is used for generating the driving force, and the electrochemical element is an electrode with a thickness of nanometer or micrometer, which is manufactured through a metal evaporation process, a screen printing process or a magnetron sputtering process;

the medicine storage component is internally provided with medicine liquid, the medicine liquid is pushed out to the outside of the medicine storage component along at least one liquid outlet hole in the medicine storage component under the driving of the driving force, so that the liquid outlet hole can administer medicine to a patient, or the medicine liquid can be administered to the patient along an injection mechanism connected to the liquid outlet hole.

Optionally, the electrode is a metal electrode, a carbon electrode or a composite conductive material electrode.

Optionally, the electrode is a finger electrode, a flat electrode, a columnar electrode or an irregular electrode.

Optionally, the substrate of the finger-inserted electrode is a hard substrate, a flexible substrate or a stretchable elastic substrate.

Optionally, the substrate may be in a curved shape, a planar shape, a sawtooth shape, a corrugated shape or a microporous shape, and the substrate may be made of glass, polyethylene terephthalate (PET) or Polyimide, Parylene, Polyurethane, polycarbonate, polyester, thermoplastic Polyurethane elastomer (TPU), polyvinyl chloride (PVC), chitosan, polylactic acid, silicone, rubber, latex, thermoplastic elastomer (TPE), perfluoroethylene propylene copolymer (FEP), and Polytetrafluoroethylene (PTFE).

Optionally, the driving component further includes a driving cavity covering the electrochemical element, and the driving cavity is located inside the medicine storage component;

the driving cavity is used for containing electrolyte, the electrolyte generates electrochemical reaction under the action of the electrochemical element, so that the driving cavity generates deformation, and the deformation of the driving cavity generates driving force for the liquid medicine.

Optionally, the electrolyte is pure water or a salt solution.

Optionally, the liquid medicine is insulin injection.

Optionally, the concentration of the insulin injection is 1-500U/ml.

A method for manufacturing a medication infusion pump, for manufacturing a medication infusion pump as described above, the method comprising the steps of:

fabricating the electrode on the substrate;

bonding the driving cavity on the substrate, completely coating the electrode, and filling the electrolyte into the driving cavity;

and forming the medicine storage part on the substrate, and enabling the medicine storage part to completely cover the driving cavity.

According to the technical scheme, the medicine injection pump based on the electrochemical reaction and the manufacturing method thereof are provided. The driving part is positioned in the medicine storage part and used for generating pushing force for the medicine storage part by utilizing current based on an electrochemical principle; the medicine storage part is internally loaded with medicine liquid and is used for pushing the medicine liquid out under the pushing of the driving part and injecting the medicine liquid to a patient. Because the electrochemical reaction can be generated based on the electric signal of the preset rule, the injection on time can be realized to the patient by controlling the input current or voltage, thereby ensuring the stability, intelligence and automation of the administration.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic diagram of an electrochemical reaction based drug injection pump according to an embodiment of the present application;

FIG. 2 is a schematic diagram of another electrochemical reaction based drug infusion pump according to an embodiment of the present application;

FIG. 3 is a schematic diagram of yet another electrochemical reaction based drug infusion pump according to an embodiment of the present application;

FIG. 4 is a schematic diagram of yet another electrochemical reaction based drug infusion pump according to an embodiment of the present application;

FIG. 5 is a schematic view of yet another electrochemical reaction based drug infusion pump according to an embodiment of the present application;

FIG. 6 is a schematic diagram of yet another electrochemical-based drug infusion pump in accordance with an embodiment of the present application;

FIG. 7 is a schematic view of a substrate having a curved shape according to an embodiment of the present application;

FIG. 8 is a schematic view of a substrate having a saw-tooth shape according to an embodiment of the present application;

FIG. 9 is a schematic view of another curved substrate according to an embodiment of the present application;

fig. 10 is a schematic view of a hollow microneedle-shaped substrate according to an embodiment of the present application;

FIG. 11a is a schematic diagram illustrating a normal state of a corrugated substrate according to an embodiment of the present application;

FIG. 11b is a schematic diagram of a stretched state of the corrugated substrate according to the embodiment of the present application;

FIG. 12 is a schematic view of yet another electrochemical reaction based drug infusion pump in accordance with an embodiment of the present application;

FIG. 13 is a top view of a platinum finger electrode in accordance with an embodiment of the present application;

FIG. 14 is a schematic view of a plate electrode according to an embodiment of the present application;

FIG. 15 is a schematic view of another plate electrode according to an embodiment of the present application;

FIG. 16 is a schematic view of a cylindrical electrode according to an embodiment of the present application;

fig. 17 is a flowchart of a method for manufacturing a medication injection pump according to an embodiment of the present application.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Example one

Fig. 1 is a schematic diagram of a drug injection pump based on electrochemical reaction according to an embodiment of the present application.

As shown in fig. 1, the present embodiment provides a medicine injection pump including a driving part 20 and a medicine storage part 10, the driving part being disposed inside the medicine storage part.

The medicine storage part is a part with a cavity, liquid medicine for injection is contained in the cavity, and the medicine storage part is provided with at least one liquid outlet hole 11. The driving part is arranged in the medicine storage part and generates pushing force based on the electrochemical principle, namely based on the action of current input by control equipment outside.

Under the action of the pushing force generated by the driving part, the medicine storage part discharges the liquid medicine through the liquid outlet hole by deformation or pressure change, and the liquid outlet hole realizes the injection to the patient through the guide tube 12 and the microneedle array 13, as shown in fig. 2. When the medicine injection pump is arranged inside a human body, the liquid outlet hole can be used for administering medicine to a patient without an additional element.

In one embodiment of the present application, the corresponding portion of the drug storage cavity is provided with a liquid injection hole 14 in addition to the liquid outlet hole, as shown in fig. 3, the liquid injection hole can be used for injecting the drug liquid into the drug storage cavity, and the movable plug 15 is used for sealing after the injection is completed.

The diameter of the liquid injection hole is 1-5 mm, and the diameter of the liquid outlet hole is 1-5 mm. In the present embodiment, the diameter of the liquid inlet is preferably 3mm, and the diameter of the liquid outlet is also preferably 3 mm. The sizes of the liquid injection hole and the liquid outlet hole can be in the micron order.

The driving member is used to generate the above-mentioned urging force based on the principle of electrochemical reaction. The electrochemical element is connected to the outside of the medicine storage member through a lead wire 21 for receiving an electric current outputted from the control apparatus 100, as shown in fig. 4, and generates a gas based on the electric current, whereby it exerts an urging force on the liquid medicine of the medicine storage member by expansion of volume. The voltage range of the driving voltage is 0.1-20V, and the voltage is the normal tolerance voltage of a human body and cannot harm the human body. In addition, the driving voltage can also be a driving current with a constant value of 0.1-10 milliamperes.

In addition, as mentioned above, the drug injection pump of the present application may be disposed inside the human body, and at this time, a control device with a battery may be integrally disposed with the pump, as shown in fig. 5 and 6, to achieve autonomous operation in the human body for a long time.

The driving component comprises an electrochemical element, and the electrochemical element comprises at least one pair of electrodes which are connected with the control equipment through leads. The electrode is a metal electrode or a composite conductive material electrode. When the metal electrode is selected, platinum, gold, silver, copper and the like can be adopted, and a carbon material electrode can also be selected. The electrode causes water or other components in the liquid medicine to undergo oxidation-reduction reaction or electrolysis reaction based on the current, thereby generating corresponding gas.

The electrodes are arranged on a substrate, which may be considered as a part of the electrodes, for carrying the electrode material. The substrate may have a planar shape, a curved shape, a zigzag shape, a microneedle shape, or a corrugated shape, as shown in fig. 7, 8, 9, and 10. The shape of the substrate may also be a corrugated shape, with the electrodes attached to the corrugated substrate as shown in fig. 11a, and when the substrate is stretched, the electrodes deform with it as shown in fig. 11 b. When selecting the material of base plate, can select flexible material as the base plate for use, also can select hard materials such as glass as the base plate for use, can also select the elastic base that can stretch for use.

According to the technical scheme, the embodiment provides the drug injection pump based on the electrochemical reaction, which comprises a driving part and a drug storage part. The driving part is positioned in the medicine storage part and used for generating pushing force for the medicine storage part by utilizing current based on an electrochemical principle; the medicine storage part is internally loaded with medicine liquid and is used for pushing the medicine liquid out under the pushing of the driving part and injecting the medicine liquid to a patient. Because the electrochemical reaction can be generated based on the electric signal of a preset rule, the injection on time can be realized for a patient by controlling the input current or voltage, thereby ensuring the stability, intelligence and automation of the administration.

The medicine in the medicine injection pump in the application can be insulin injection, and the concentration of the medicine injection pump can be controlled to be 1-500U/ml, so that the medicine injection pump becomes an insulin pump for automatically supplementing insulin for a diabetic patient.

In another embodiment of the present application, the drive component further comprises a drive cavity 30, as shown in fig. 12. The driving cavity is positioned in the medicine storage component and covers the electrochemical component, electrolyte is loaded in the driving cavity, the electrolyte generates redox reaction under the action of an electrochemical element, and the generated gas drives the driving cavity to expand so as to generate driving force for liquid medicine in the medicine storage component. The electrolyte can be selected from pure water, salt solution, etc.

The driving cavity may be made of PTFE, PDMS, polyacrylate, silica gel, rubber, latex, polyurethane, parylene or polyimide.

The electrochemical element is preferably a platinum finger electrode comprising interdigitated platinum electrode pads having a width of 100 μm and a distance of 100 μm as shown in fig. 13. The platinum finger electrode is connected to the outside of the drug storage member through a lead wire for receiving current through the lead wire.

The electrodes in an electrochemical cell have an overall area of 1 mm to 1 cm and a thickness of typically 50 nm to 500 μm. The electrode can be manufactured by a sputtering or evaporation method of micro-nano processing, and the material of the electrode can be platinum, gold or other materials with stable chemical properties, and can also be manufactured by a screen printing method.

The drive chamber is formed by the assembly of a base plate and a cover plate, which are bonded together at their edges by adhesive bonding, thereby forming a cavity therein for receiving the electrolyte and the electrochemical element. The diameter of the cover plate is preferably 8mm, and the height is preferably 7 mm.

The medicine storage part in the embodiment can be produced by a 3D printing process, an injection molding process or other processes, the material of the medicine storage part is preferably Teflon material, and the thickness of the film is preferably 30 μm. The size of the medicine storage part is 20mm in diameter and 10mm in height.

In addition, the electrodes in this embodiment may also be in the form of two plate electrodes facing each other up and down, in addition to the platinum finger electrode, where one plate electrode is located on the substrate, and the other plate electrode is located above the substrate, as shown in fig. 14, and the other plate electrode may also be located on the inner wall of the driving cavity, as shown in fig. 15.

Alternatively, the electrodes may be two or two sets of electrodes standing upright on the substrate, as shown in fig. 16.

Example two

Fig. 17 is a flowchart of a method for manufacturing a medication injection pump according to an embodiment of the present application.

Referring to fig. 17, the manufacturing method of the medication injection pump provided in this embodiment is used for manufacturing the medication injection pump provided in the previous embodiment. The method specifically comprises the following steps:

s1, two electrodes are formed on the substrate.

Specifically, the electrodes are fabricated on the substrate by a magnetron sputtering process, a screen printing process, a metal evaporation process or other processes. The base plate then forms the basis for the fabrication of the entire drug infusion pump. The substrate can be made of glass, plastic, polyethylene terephthalate (PET), Polyimide, Polyurethane, polycarbonate, polyester, thermoplastic Polyurethane elastomer (TPU), polyvinyl chloride (PVC), chitosan, polylactic acid, silica gel, rubber, latex, thermoplastic elastomer (TPE), perfluoroethylene propylene copolymer (FEP) and Polytetrafluoroethylene (PTFE).

The electrode is a platinum finger electrode, a carbon finger electrode, a gold finger electrode or a composite conductive material finger electrode, that is, a finger electrode made of platinum material, carbon material, gold material or composite conductive material, and the present embodiment describes the finger electrode by taking the platinum finger electrode as an example, and the platinum finger electrode includes a titanium layer attached to a substrate and a platinum layer attached to the titanium layer.

The size of the substrate is 2x2cm, when in manufacturing, a titanium film and a platinum film are sequentially deposited on a glass substrate, and then the manufacturing of the platinum finger electrode is realized through a photoetching process, namely, redundant films are removed through coating photoresist, photoetching and etching, so that the platinum finger electrode is formed. Upon formation of the corresponding electrodes, determination of the polarity of the electrodes was achieved by passing them into deionized water in solution with acetone and isopropanol.

And S2, arranging a driving cavity covering the electrodes on the substrate.

Specifically, the driving cavity is adhered to the substrate through a sealing adhesive, and the electrode is covered.

S3, manufacturing a medicine storage part covering the driving cavity on the substrate.

And finally, generating the Teflon medicine storage component on the substrate through a 3D printing mode, an injection molding process or other processes, so that the Teflon medicine storage component can completely cover the driving cavity.

The manufacturing of the medicine injection pump can be realized through the arrangement.

For the device embodiment, since it is basically similar to the method embodiment, the description is simple, and for the relevant points, refer to the partial description of the method embodiment.

The embodiments in the present specification are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.

While preferred embodiments of the present application have been described, additional variations and modifications of these embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including the preferred embodiment and all changes and modifications that fall within the true scope of the embodiments of the present application.

Finally, it should also be noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or terminal that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or terminal. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in the process, method, article, or terminal equipment comprising the element.

The technical solutions provided by the present application are introduced in detail above, and specific examples are applied in the present application to explain the principles and embodiments of the present application, and the descriptions of the above examples are only used to help understanding the method and the core ideas of the present application; meanwhile, for a person skilled in the art, according to the idea of the present application, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present application.

Claims (10)

1. A drug injection pump based on electrochemical reaction, comprising a driving part and a drug storage part, wherein:

the driving component is arranged inside the medicine storage component and used for generating a driving force based on an electrochemical reaction principle, the driving force is applied inside the medicine storage component, the driving component comprises an electrochemical element, the electrochemical element is connected to the outside of the medicine storage component through a lead and used for receiving preset current, the electrochemical element is used for generating gas based on the preset current, the gas is used for generating the driving force, and the electrochemical element is an electrode with a thickness of nanometer or micrometer, which is manufactured through a metal evaporation process, a screen printing process or a magnetron sputtering process;

the medicine storage component is internally provided with medicine liquid, the medicine liquid is pushed out to the outside of the medicine storage component along at least one liquid outlet hole in the medicine storage component under the driving of the driving force, so that the liquid outlet hole can administer medicine to a patient, or the medicine liquid can be administered to the patient along an injection mechanism connected to the liquid outlet hole.

2. The drug infusion pump of claim 1, wherein the electrode is a metal electrode, a carbon electrode, or a composite conductive material electrode.

3. The drug infusion pump of claim 2, wherein the electrode is a finger electrode, a flat plate electrode, a cylindrical electrode, or an irregularly shaped electrode.

4. The drug syringe pump of claim 3, wherein the substrate of the interdigitated electrode is a rigid substrate, a flexible substrate, or a stretchable elastomeric substrate.

5. The drug infusion pump of claim 4, wherein the substrate has a curved shape, a planar shape, a serrated shape, a corrugated shape, or a microporous shape.

6. The drug infusion pump of claim 1, wherein said drive member further comprises a drive cavity encasing said electrochemical element, said drive cavity being located inside said drug storage member;

the driving cavity is used for containing electrolyte, the electrolyte generates electrochemical reaction under the action of the electrochemical element, so that the driving cavity generates deformation, and the deformation of the driving cavity generates driving force for the liquid medicine.

7. The drug infusion pump of claim 6, wherein the electrolyte is pure water or a saline solution.

8. The drug infusion pump of claim 1, wherein said medical fluid is an insulin infusion fluid.

9. The drug infusion pump of claim 8, wherein the concentration of said insulin infusion is 1 to 500U/ml.

10. A method for manufacturing a drug injection pump, for manufacturing the drug injection pump according to any one of claims 6 to 8, the method comprising the steps of:

fabricating the electrode on the substrate;

bonding the driving cavity on the substrate, completely coating the electrode, and filling the driving cavity with the electrolyte;

and forming the medicine storage part on the substrate, and enabling the medicine storage part to completely cover the driving cavity.

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