CN115096663B - Sampling device for neurology inspection - Google Patents

Sampling device for neurology inspection Download PDF

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CN115096663B
CN115096663B CN202211036926.7A CN202211036926A CN115096663B CN 115096663 B CN115096663 B CN 115096663B CN 202211036926 A CN202211036926 A CN 202211036926A CN 115096663 B CN115096663 B CN 115096663B
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tube
packaging
bag
rubber ball
spherical shell
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CN115096663A (en
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马春丽
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Mudanjiang Medical University
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Mudanjiang Medical University
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0077—Cerebrospinal fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices
    • G01N2001/1418—Depression, aspiration

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Abstract

The invention discloses a sampling device for neurology inspection, which comprises test paper, a tube assembly and a suction assembly, wherein the tube assembly comprises a tube; the pipe assembly comprises a pipe body, a lower end cover, a rubber ball and a processing port; the tube body is a transparent tube, and the test paper is fixed in the tube body; the rubber ball is communicated with one end of the tube body, which is far away from the lower end cover, and can suck gas in the tube body to enable the tube body to be in a negative pressure state; the suction component is used for quantitatively sucking cerebrospinal fluid; the suction assembly comprises a spherical shell, a soft bag and a suction tube; the spherical shell is spherical and is fixedly connected with the opening at the bottom end of the pipe body in a sealing way; a part of the spherical shell, which is positioned in the tube body, is provided with a liquid leakage port close to the test paper, a puncture needle is fixed on the spherical shell, and the needle point points to the liquid leakage port; the soft bag is positioned in the spherical shell, the soft bag is in an initial state of internal vacuum, the volume after expansion is larger than that of the spherical shell, and the soft bag can extend out of the liquid leakage port and be punctured by the puncture needle after expansion. The device can extract cerebrospinal fluid fast and quantitatively.

Description

Sampling device for neurology inspection
Technical Field
The invention relates to a device for detecting neurology, in particular to a kit for detecting cerebrospinal fluid.
Background
In the prior art, the measurement of cerebrospinal fluid protein is carried out by pyrogallol red colorimetry. Chinese patent CN109738656B provides a liquid crystal composition prepared from succinic acid, sodium benzoate, oxalic acid, ammonium molybdate, methanol and pyrogallol red according to the following weight ratio: 17.80g/L:0.4320g/L:0.0900g/L:0.0360g/L:10.00ml/:0.0240g/L; the prepared reagent is soaked in test paper, and cerebrospinal fluid is dripped after the test paper is dried to detect the protein content.
However, during actual testing, cerebrospinal fluid is sampled by a dropper and is dripped onto the test paper. On one hand, the quantitative sampling process needs manual control, and the sampling amount of each time is different; secondly, the size and the placement position of the test paper need to be quantified.
Disclosure of Invention
The embodiment of the application provides a sampling device for department of neurology inspection, has solved the inaccurate problem of sample ration among the prior art, has realized the effect of quick quantitative sample.
The embodiment of the application provides a sampling device for neurology inspection, which comprises test paper, a tube assembly and a suction assembly;
the pipe assembly comprises a pipe body, a lower end cover, a rubber ball and a processing port;
the tube body is a transparent tube, and the test paper is fixed in the tube body;
the pipe wall of the pipe body is provided with an opening which is a processing opening; the one-way valve can be detachably fixed in the treatment port; allowing gas to be vented through the one-way valve;
the bottom end of the tube body is detachably fixed with the lower end cover;
the rubber ball is communicated with one end of the pipe body, which is far away from the lower end cover, and can suck gas in the pipe body to enable the inside of the pipe body to be in a negative pressure state;
the suction assembly is used for quantitatively sucking cerebrospinal fluid;
the suction assembly comprises a spherical shell, a soft bag and a suction tube;
the spherical shell is spherical and is fixedly connected with the opening at the bottom end of the pipe body in a sealing way;
a part of the spherical shell, which is positioned in the tube body, is provided with a liquid leakage port close to the test paper, a puncture needle is fixed on the spherical shell, and the needle point points to the liquid leakage port;
the soft bag is positioned in the spherical shell, the soft bag is internally vacuum in the initial state, the volume after expansion is larger than that of the spherical shell, and the soft bag can extend out of the liquid leakage port and be punctured by the puncture needle after expansion;
the suction tube is communicated with the spherical shell, and a second one-way valve is arranged in the suction tube, so that the rubber ball can suck cerebrospinal fluid when generating negative pressure in the tube body, but the cerebrospinal fluid can not flow back through the suction tube.
Furthermore, a second one-way valve in the suction tube is a rubber sheet with a through hole in the center, and the edge of the rubber sheet is fixedly connected with the inner wall of the suction tube in a sealing manner.
Furthermore, the processing port is a threaded port, and the one-way valve is screwed into the processing port through threads and is connected in an airtight mode.
Furthermore, the reagent is packaged by a plastic bag, and when the test paper needs to be soaked, the plastic bag is punctured, so that the reagent flows onto the test paper.
The packaging assembly comprises a packaging bag, a spacer, a packaging tank, an inner tube and a bag opening;
the packaging bag is a plastic bag; the top end of the packaging bag is fixedly connected with the bottom end of the rubber ball;
a plurality of through holes with the same size are longitudinally formed in one side surface of the packaging bag, and through holes corresponding to the through holes in the packaging bag are formed in the isolating sheet; the isolating sheet is fixedly adhered to the packaging bag;
the opening end of the packaging tank is fixedly connected with the through hole on the spacer in a sealing way; the isolating sheet is fixedly connected with the pipe body, so that the liquid in the packaging tank can naturally and completely flow out of the packaging tank when the liquid is not obstructed; the number of the packaging tanks is the same as that of the through holes on the isolation sheet;
the packaging bag is internally provided with a soft film tube which is a tube made of a plastic soft film and is fixed in the packaging bag, the top end of the soft film tube is positioned above the uppermost packaging can, and the bottom end of the soft film tube is positioned below the lowermost packaging can; the flexible membrane tube crosses the tank openings of all the packaging tanks;
the inner wall of the packaging bag is adhered in an initial state, so that the liquid in the packaging tank cannot flow out;
the mouth of the packaging bag faces downwards, and the mouth of the packaging bag is bonded and sealed; a U-shaped part is reserved at the bonding part of the bag opening and is not bonded to form an inner tube, and the bottom end of the soft film tube is communicated with one tube opening of the inner tube; the bottom opening of the rubber ball is communicated with an air pipe, and the bottom opening of the air pipe is communicated with the other pipe orifice of the inner pipe.
Further, the packaging bag is a transparent bag.
Further, the bonding manner uses pressure sensitive adhesive or thermocompression bonding.
Furthermore, the device also comprises an upper end cover, wherein the upper end cover comprises a top cover, a middle cover and a lower cover;
the upper end cover is detachably fixed with the top of the tube body, and the rubber ball is positioned in the upper end cover;
the lower cover is cylindrical and is detachably fixed with the pipe body; the middle cover is also cylindrical and is detachably fixed with the top end of the lower cover;
the top cover is cylindrical, the top surface of the top cover is closed, and the top cover and the top end of the middle cover are detachably fixed;
after the top cover is removed, the rubber ball is pressed to enable the rubber ball to be inwards sunken until the top of the rubber ball is positioned at the top edge of the middle cover, so that the inner wall of the packaging bag can be separated from bonding, and liquid in the packaging tank can flow out;
after the middle cover is detached, the pressing rubber ball is inwards sunken until the top of the rubber ball is positioned at the top edge of the lower cover, so that liquid in the packaging tank can be completely sucked;
demolish the lower cover after, press the glueballs inwards sunken, be close the body top to glueballs top, can make the sack open, make reagent flow.
Furthermore, a funnel is fixed on the upper part of the tube body, and the bottom end of the funnel is fixedly connected with the top end of the test paper, so that the reagent can directionally flow onto the test paper.
Further, the package cans are the same size.
One or more technical solutions provided in the embodiments of the present application have at least the following technical effects or advantages: utilize negative pressure to aspirate a volume limited soft bag and aspirate cerebrospinal fluid, can realize quick quantitative suction operation, make the detection quick convenient, and accurate.
Drawings
FIG. 1 is a schematic view of the structure of the present invention;
FIG. 2 is a schematic diagram showing the structure of the suction assembly and the test paper when the soft bag is not in a suction state;
FIG. 3 is a schematic diagram showing the structure of the suction assembly in cooperation with the test paper in a fully inflated state of the balloon;
FIG. 4 is a schematic diagram showing the structure of the sucking assembly in cooperation with the test paper in a state after the soft capsule is punctured;
FIG. 5 is a schematic view of the device as it aspirates cerebrospinal fluid;
FIG. 6 is a schematic structural view of the present invention with a package assembly;
FIG. 7 is a schematic view of the package assembly shown after air intake with the inner walls of the package detached from bonding;
FIG. 8 is a schematic view of the bag opening being out of adhesion;
fig. 9 is a schematic view of a mating structure of the rubber ball and the package assembly.
In the figure, a pipe assembly 100, a pipe body 110, a lower end cover 120, a rubber ball 130, a spacer 131, an air pipe 132, a processing port 140, an upper end cover 150, a top cover 151, a middle cover 152 and a lower cover 153;
test paper 200;
the suction assembly 300, the spherical shell 310, the leakage port 311, the puncture needle 312, the soft bag 320 and the suction tube 330;
the packaging assembly 400, the packaging bag 410, the film tube 411, the spacer 420, the packaging tank 430, the inner tube 440 and the bag mouth 450;
a funnel 500.
Detailed Description
To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only and do not represent the only embodiments.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Utilize negative pressure suction a volume restricted's soft bag to aspirate cerebrospinal fluid, can realize quick quantitative aspiration operation, make the detection quick convenient, and accurate.
As shown in fig. 1 to 5, a sampling device for neurology examination comprises a test paper 200, a tube assembly 100 and a suction assembly 300;
the tube assembly 100 includes a tube body 110, a lower end cap 120, a rubber ball 130, and a treatment port 140;
the tube body 110 is a transparent tube, and the test paper 200 is fixed in the tube body 110;
the pipe wall of the pipe body 110 is provided with an opening which is a processing opening 140; a one-way valve is detachably fixed in the treatment port 140; so that the gas can be discharged through the one-way valve;
the lower end cover 120 is detachably fixed at the bottom end of the tube body 110;
the rubber ball 130 is communicated with one end of the tube body 110 far away from the lower end cover 120, and the rubber ball 130 can suck gas in the tube body 110 to enable the interior of the tube body 110 to be in a negative pressure state;
the suction assembly 300 is used for quantitatively sucking cerebrospinal fluid;
the suction assembly 300 comprises a spherical shell 310, a soft balloon 320 and a suction tube 330;
the spherical shell 310 is spherical, and the spherical shell 310 is fixedly connected with the bottom opening of the tube body 110 in a sealing manner;
a liquid leakage port 311 is arranged at the part of the spherical shell 310, which is positioned in the tube body 110, close to the test paper, a puncture needle 312 is fixed on the spherical shell 310, and the needle point points to the liquid leakage port 311;
the soft bag 320 is positioned in the spherical shell 310, the soft bag 320 is in an initial state of internal vacuum, the volume after expansion is larger than that of the spherical shell 310, and the soft bag 320 can extend out of the liquid leakage port 311 and be punctured by the puncture needle 312 after expansion;
the suction tube 330 is communicated with the spherical shell 310, and a second one-way valve is arranged in the suction tube 330, so that the cerebrospinal fluid can be sucked when the rubber ball 130 generates negative pressure in the tube body 110, but the cerebrospinal fluid cannot flow back through the suction tube 330.
The test paper 200 is fixed in the transparent tube 110, and the change of the test paper can be observed at any time. Through the treatment port of the detachable one-way valve, the prepared reagent can be dripped into the test paper.
As shown in fig. 1-5, in use:
step one, preparing a detection reagent, dripping the detection reagent on the test paper 200 through the processing port 140, soaking the test paper, and installing a one-way valve in the processing port 140 after the test paper is dried; and the lower cap 120 is removed;
step two, inserting the suction tube 330 into the cerebrospinal fluid, and squeezing the rubber ball 130 to discharge the gas in the tube body 110 from the treatment port 140, wherein the external gas cannot enter the tube body 110 due to the action of the one-way valve, so that the rubber ball 130 can generate negative pressure in the tube body 110;
and step three, loosening the rubber ball 130, enabling the cerebrospinal fluid to enter the soft bag 320 through the suction tube 330, wherein the expanded part of the soft bag 320 extends out of the fluid leakage port 311 and is punctured by the puncture needle 312, and at the moment, the cerebrospinal fluid flows out of the soft bag 320 and flows onto the test paper.
Because the soft capsule 320 is limited by the volume of the spherical shell 310, the quantity of the aspirated cerebrospinal fluid is basically constant, the cerebrospinal fluid is directly punctured by the puncture needle after aspiration, and the quantity of the cerebrospinal fluid can be quickly, conveniently and stably detected under the condition that the reagent quantity is consistent with the size of the test paper.
The device does not need to accurately control the extrusion intensity, extrusion amount and other operation processes of the rubber ball during sampling operation. Accurate sampling can be completed by a single press.
The second one-way valve in the suction tube 330 can be a rubber sheet with a through hole in the center, the edge of the rubber sheet is fixedly connected with the inner wall of the suction tube 330 in a sealing manner, the center through hole can be opened in a negative pressure state in the tube body 110, and the center through hole is in a closed state without external force. Under the non-negative pressure suction state, the through hole can be plugged by the self elasticity of the rubber, and when pressure exists, the rubber sheet is convexly deformed towards the negative pressure source to open the through hole. It is commonly used in beverage bottles, nipples, etc. which can only be drained by sucking.
The treatment port 140 may be a threaded port with a one-way valve threaded into the treatment port, hermetically sealed.
Example two
After the reagent is prepared, the reagent needs to be used as soon as possible, because the reagent contains volatile components, and the reagent has large change in components after long-term storage due to the control of the pH value. Thus, it is desirable that the reagents be packaged in disposable packages and dosed as shown in FIGS. 6-8.
The reagent is encapsulated by the plastic bag, and when the test paper 200 needs to be soaked, the plastic bag is punctured, so that the reagent flows onto the test paper.
The plastic bag is fixed near the disposal port 140, and the puncturing needle is inserted into the tubular body 110 through the disposal port to puncture the plastic bag. Like this, through ration encapsulated reagent and ration sample cerebrospinal fluid, protein amount in can quick effectual accurate survey cerebrospinal fluid.
EXAMPLE III
The reagent has a plurality of components, and after being mixed, the reagent is packaged in a plastic bag for a long time, and after being mixed, acid, phenol and alcohol are easy to react to cause the reagent to lose efficacy, so that different components can be packaged respectively and are mixed when in use. As shown in fig. 6-9.
Further comprising a packaging assembly 400, the packaging assembly 400 comprising a packaging pouch 410, a spacer 420, a packaging can 430, an inner tube 440, and a bag mouth 450;
the packaging bag 410 is a plastic bag; the top end of the packaging bag 410 is fixedly connected with the bottom end of the rubber ball 130;
the envelope 410 is preferably a transparent bag;
a plurality of through holes with the same size are longitudinally arranged on one side surface of the packaging bag 410, and the spacer 420 is provided with through holes corresponding to the through holes on the packaging bag 410; the spacer 420 is fixedly adhered to the envelope 410;
the open end of the packaging can 430 is fixedly connected with the through hole on the spacer 420 in a sealing way; the isolation sheet 420 is fixedly connected with the tube body 110, so that the liquid in the packaging tank 430 can naturally and completely flow out of the packaging tank 430 when the liquid is not blocked; the number of the packaging tanks is the same as that of the through holes on the isolating sheet;
a flexible film tube 411 is arranged in the packaging bag and is a tube made of a plastic flexible film, the flexible film tube 411 is fixed in the packaging bag 410, the top end of the flexible film tube 411 is positioned above the topmost packaging tank 430, and the bottom end of the flexible film tube 411 is positioned below the bottommost packaging tank 430; the flexible film tube 411 spans the openings of all the packaging cans 430;
the inner wall of the packaging bag 410 is adhered in an initial state, so that the liquid in the packaging tank 430 cannot flow out;
the bag 410 has a downward opening 450, and the opening 450 is sealed by bonding; the bonding part of the bag mouth 450 is reserved with a U-shaped part which is not bonded to form an inner tube 440, and the bottom end of the soft membrane tube 411 is communicated with one tube opening of the inner tube 440; the bonding means may be accomplished using pressure sensitive adhesive, heat press or other applicable glues.
The bottom opening of the rubber ball 130 is communicated with an air tube 132, and the bottom opening of the air tube 132 is communicated with the other nozzle of the inner tube 440.
In the actual working process of the device,
when the rubber ball 130 is pressed, the air enters the packaging bag 410 through the air pipe 132, the inner pipe 440 and the film tube 411, and the packaging bag 410 is gradually opened from top to bottom, so that the liquid in the packaging tank 430 flows out, and finally the liquid can flow into the inner pipe.
Thereafter, the reagent can be sucked into the rubber ball 130 by repeatedly pressing the rubber ball 130, and the reagent can be mixed by repeatedly pressing the rubber ball 130.
Finally, the pressing amount of the rubber ball is increased, so that the bag mouth 450 is also opened, and the reagent flows onto the test paper 200.
Because the reagent amount is not large, a spacer 131 can be fixed in the rubber ball 130, and the spacer 131 is a soft piece and does not influence the deformation of the rubber ball; the periphery of the spacer 131 is hermetically fixed with the inner wall of the rubber ball 130, a through hole is formed in the center of the spacer 131, and the top end of the air pipe 132 is communicated with the through hole of the spacer 131; at this time, the outer diameter of the air tube 132 is smaller than the bottom opening of the rubber ball 130. Thus, the above operation can be completed by pressing the top of the rubber ball 130 a little.
In order to be able to perform this operation quickly and accurately, it is avoided that the gas volume is too large, causing the bag mouth 450 to break prematurely. An upper end cover 150 is added, and the upper end cover 150 comprises a top cover 151, a middle cover 152 and a lower cover 153;
the upper end cap 150 is detachably fixed to the top of the tube body 110, and the rubber ball 130 is located in the upper end cap 150;
the lower cover 153 is cylindrical and is detachably fixed to the pipe body 110; the middle cover 152 is also cylindrical and is detachably fixed with the top end of the lower cover;
the top cover 151 is cylindrical, has a closed top surface, and is detachably fixed with the top end of the middle cover 152;
after the top cover 151 is removed, the rubber ball 130 is pressed to be recessed inwards until the top of the rubber ball is positioned at the top edge of the middle cover 152, so that the inner wall of the packaging bag 410 can be separated from bonding, and the liquid in the packaging tank 430 can flow out;
after the middle cover 152 is removed, the pressing rubber ball 130 is inwards concave until the top of the rubber ball is positioned at the top edge of the lower cover, so that the liquid in the packaging can 430 can be completely sucked;
after the lower cover 153 is removed, the pressing rubber ball 130 is recessed inwards until the top of the rubber ball approaches the top end of the tube body 110, so that the bag mouth 450 can be broken, and the reagent can flow out.
Thus, accurate and rapid mixing of reagents can be achieved and the reagents can be flowed onto the test strip.
In order to facilitate drainage, a funnel 500 is fixed on the upper portion of the tube body 110, and the bottom end of the funnel 500 is fixedly connected to the top end of the test paper 200. Allowing for the directed flow of reagents onto the test strip.
The packaging tanks 430 are of the same size, and the internal packaging liquid is arranged from top to bottom according to the proportion of the components of the internal packaging liquid in the detection reagent. When the packaging can 430 is vertically arranged, the lower side faces the inner side of the packaging bag and inclines, so that the liquid can completely flow out.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made without departing from the spirit and principle of the present invention shall fall within the protection scope of the present invention.

Claims (9)

1. A sampling device for neurology examination comprises a test paper (200), and is characterized by further comprising a tube assembly (100) and a suction assembly (300);
the pipe assembly (100) comprises a pipe body (110), a lower end cover (120), a rubber ball (130) and a processing port (140);
the tube body (110) is a transparent tube, and the test paper (200) is fixed in the tube body (110);
the pipe wall of the pipe body (110) is provided with an opening which is a processing opening (140); a one-way valve is detachably fixed in the treatment port (140); so that the gas can be discharged through the one-way valve;
the lower end cover (120) can be detachably fixed at the bottom end of the pipe body (110);
the rubber ball (130) is communicated with one end, far away from the lower end cover (120), of the tube body (110), and the rubber ball (130) can suck gas in the tube body (110) to enable the interior of the tube body (110) to be in a negative pressure state;
the suction assembly (300) is used for quantitatively sucking cerebrospinal fluid;
the suction assembly (300) comprises a spherical shell (310), a soft capsule (320) and a suction tube (330);
the spherical shell (310) is spherical, and the spherical shell (310) is fixedly connected with the opening at the bottom end of the pipe body (110) in a sealing way;
the part of the spherical shell (310) positioned in the pipe body (110) and close to the test paper is provided with a liquid leakage port (311), a puncture needle (312) is fixed on the spherical shell (310), and the needle point points to the liquid leakage port (311);
the soft bag (320) is positioned in the spherical shell (310), the soft bag (320) is in an initial state of internal vacuum, the volume after expansion is larger than that of the spherical shell (310), and the soft bag (320) can extend out of the liquid leakage port (311) and be punctured by the puncture needle (312) after expansion;
the suction tube (330) is communicated with the spherical shell (310), and a second one-way valve is arranged in the suction tube (330), so that the rubber ball (130) can suck cerebrospinal fluid when negative pressure is generated in the tube body (110), but the cerebrospinal fluid cannot flow back through the suction tube (330);
the packaging assembly (400) is further included, and the packaging assembly (400) comprises a packaging bag (410), a spacer (420), a packaging tank (430), an inner tube (440) and a bag opening (450);
the packaging bag (410) is a plastic bag; the top end of the packaging bag (410) is fixedly connected with the bottom end of the rubber ball (130);
a plurality of through holes with the same size are longitudinally formed in one side surface of the packaging bag (410), and through holes corresponding to the through holes in the packaging bag (410) are formed in the spacer (420); the isolating sheet (420) is fixedly adhered to the packaging bag (410);
the opening end of the packaging tank (430) is fixedly connected with the through hole on the spacing sheet (420) in a sealing way; the isolating sheet (420) is fixedly connected with the pipe body (110), so that the liquid in the packaging tank (430) can naturally and completely flow out of the packaging tank (430) when the liquid is not obstructed; the number of the packaging cans (430) is the same as that of the through holes on the spacer;
a soft film tube (411) is arranged in the packaging bag and is a tube made of plastic soft film, the soft film tube (411) is fixed in the packaging bag (410), the top end of the soft film tube (411) is positioned above the packaging tank (430) at the uppermost end, and the bottom end of the soft film tube (411) is positioned below the packaging tank (430) at the lowermost end; the flexible membrane tube (411) spans the openings of all the packaging tanks (430);
the inner wall of the packaging bag (410) is adhered in an initial state, so that the liquid in the packaging tank (430) cannot flow out;
the bag opening (450) of the packaging bag (410) faces downwards, and the bag opening (450) is bonded and sealed; a U-shaped part is reserved at the bonding part of the bag mouth (450) and is not bonded to form an inner tube (440), and the bottom end of the soft film tube (411) is communicated with one tube opening of the inner tube (440); the bottom opening of the rubber ball (130) is communicated with an air pipe (132), and the bottom opening of the air pipe (132) is communicated with the other pipe orifice of the inner pipe (440).
2. The sampling device for neurology examination as claimed in claim 1, wherein the second one-way valve inside the suction tube (330) is a rubber sheet with a through hole in the center, and the edge of the rubber sheet is fixedly connected with the inner wall of the suction tube (330) in a sealing manner.
3. The neurological examination sampling device of claim 1, wherein the treatment port (140) is a threaded port and the one-way valve is screwed into the treatment port, hermetically sealed.
4. The sampling device for neurology examination as set forth in claim 1, wherein the reagent is enclosed by a plastic bag, and when the test paper (200) is to be soaked, the plastic bag is punctured to allow the reagent to flow onto the test paper.
5. The sampling device for neurologic examination as defined in claim 1, wherein the packaging bag (410) is a transparent bag.
6. The sampling device for neurologic examination as defined in claim 1, wherein the adhesive means is pressure sensitive adhesive or thermocompression bonding.
7. The neurology examination sampling device of claim 1, further comprising an upper end cap (150), the upper end cap (150) comprising a top cap (151), a middle cap (152) and a lower cap (153);
the upper end cover (150) is detachably fixed with the top of the tube body (110), and the rubber ball (130) is positioned in the upper end cover (150);
the lower cover (153) is cylindrical and is detachably fixed with the pipe body (110); the middle cover (152) is also cylindrical and is detachably fixed with the top end of the lower cover;
the top cover (151) is cylindrical, the top surface of the top cover is closed, and the top cover and the top end of the middle cover (152) are detachably fixed;
after the top cover (151) is removed, the rubber ball (130) is pressed to enable the rubber ball to be inwards sunken until the top of the rubber ball is positioned at the top edge of the middle cover (152), so that the inner wall of the packaging bag (410) can be separated from bonding, and liquid in the packaging tank (430) can flow out;
after the middle cover (152) is detached, the rubber ball (130) is pressed to be inwards concave until the top of the rubber ball is positioned at the top edge of the lower cover, so that liquid in the packaging can (430) can be completely sucked;
after the lower cover (153) is detached, the pressing rubber ball (130) is inwards sunken until the top of the rubber ball is close to the top end of the tube body (110), so that the bag mouth (450) can be broken, and the reagent flows out.
8. The sampling device for neurology examination as claimed in claim 7, wherein a funnel (500) is fixed to an upper portion of the tube (110), and a bottom end of the funnel (500) is fixedly connected to a top end of the test strip (200) to allow the reagent to flow onto the test strip in a directional manner.
9. The sampling device for neurologic examination as defined in claim 8, wherein the packaging canisters (430) are the same size.
CN202211036926.7A 2022-08-29 2022-08-29 Sampling device for neurology inspection Active CN115096663B (en)

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